http://togogenome.org/gene/9685:RPL23 ^@ http://purl.uniprot.org/uniprot/M3WKT7 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9685:DYDC1 ^@ http://purl.uniprot.org/uniprot/M3X070 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9685:BCOR ^@ http://purl.uniprot.org/uniprot/A0A337S9Z2|||http://purl.uniprot.org/uniprot/A0A5F5XCG1|||http://purl.uniprot.org/uniprot/M3W2Z6 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9685:LOC101096566 ^@ http://purl.uniprot.org/uniprot/M3WL43 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:FAM229B ^@ http://purl.uniprot.org/uniprot/M3WVH7 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9685:MYO9B ^@ http://purl.uniprot.org/uniprot/M3VVT2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9685:GNB1 ^@ http://purl.uniprot.org/uniprot/M3WU86 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9685:FAM199X ^@ http://purl.uniprot.org/uniprot/M3W605 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/9685:IDH3B ^@ http://purl.uniprot.org/uniprot/A0A5F5XFX5|||http://purl.uniprot.org/uniprot/M3WKR2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9685:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/A0A337ST58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9685:PPIF ^@ http://purl.uniprot.org/uniprot/M3XFI8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9685:CPLANE2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U005 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.|||cilium basal body http://togogenome.org/gene/9685:HOGA1 ^@ http://purl.uniprot.org/uniprot/M3XDF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9685:ATIC ^@ http://purl.uniprot.org/uniprot/M3WB05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||cytosol http://togogenome.org/gene/9685:PSMC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUT8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9685:LOC101082541 ^@ http://purl.uniprot.org/uniprot/M3WCP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:EDN1 ^@ http://purl.uniprot.org/uniprot/M3WLG0|||http://purl.uniprot.org/uniprot/Q5NRQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).|||Secreted http://togogenome.org/gene/9685:SLC13A5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9685:TCP11L1 ^@ http://purl.uniprot.org/uniprot/M3X7I2 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9685:SNU13 ^@ http://purl.uniprot.org/uniprot/M3XA70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9685:SLC10A1 ^@ http://purl.uniprot.org/uniprot/M3WAC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9685:DDX6 ^@ http://purl.uniprot.org/uniprot/M3WXQ4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9685:VEGFA ^@ http://purl.uniprot.org/uniprot/Q95LQ4 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9685:GMFB ^@ http://purl.uniprot.org/uniprot/A0A337S765 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9685:EIF3K ^@ http://purl.uniprot.org/uniprot/A0A337SMZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:DBX1 ^@ http://purl.uniprot.org/uniprot/M3XFV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ARPC5L ^@ http://purl.uniprot.org/uniprot/M3X385 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/9685:FREM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UP49 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9685:MINDY2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UP04|||http://purl.uniprot.org/uniprot/A0A5F5XNU2|||http://purl.uniprot.org/uniprot/A0A5F5XPG8 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9685:SPSB1 ^@ http://purl.uniprot.org/uniprot/M3XC71 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/9685:GPD1 ^@ http://purl.uniprot.org/uniprot/M3WBH7 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9685:LOC101082580 ^@ http://purl.uniprot.org/uniprot/M3WVU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:FIGN ^@ http://purl.uniprot.org/uniprot/A0A2I2UPT9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9685:LHB ^@ http://purl.uniprot.org/uniprot/O77805 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|||Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.|||Secreted http://togogenome.org/gene/9685:GPER1 ^@ http://purl.uniprot.org/uniprot/A0A337SDC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:TPM4 ^@ http://purl.uniprot.org/uniprot/M3WAL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9685:LOC105260757 ^@ http://purl.uniprot.org/uniprot/M3W082 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ADGRG3 ^@ http://purl.uniprot.org/uniprot/M3W8B0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:OXR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWJ0|||http://purl.uniprot.org/uniprot/A0A5F5XCC5|||http://purl.uniprot.org/uniprot/A0A5F5XU14|||http://purl.uniprot.org/uniprot/M3XEV3 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/9685:LOC101092708 ^@ http://purl.uniprot.org/uniprot/A0A5K1UH56 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9685:DMBX1 ^@ http://purl.uniprot.org/uniprot/M3WFX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:NRM ^@ http://purl.uniprot.org/uniprot/A0A337SB86|||http://purl.uniprot.org/uniprot/M3W866 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9685:NKX6-3 ^@ http://purl.uniprot.org/uniprot/M3WHY0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ITGA4 ^@ http://purl.uniprot.org/uniprot/M3WE16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9685:PRPF4 ^@ http://purl.uniprot.org/uniprot/M3W473 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9685:HSD17B6 ^@ http://purl.uniprot.org/uniprot/M3VVL6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:SENP6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFB5 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9685:KHDRBS1 ^@ http://purl.uniprot.org/uniprot/M3W616 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9685:LIPM ^@ http://purl.uniprot.org/uniprot/A0A337SEA4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9685:PDCD4 ^@ http://purl.uniprot.org/uniprot/M3WFY9 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9685:CCNYL1 ^@ http://purl.uniprot.org/uniprot/A0A337SH46|||http://purl.uniprot.org/uniprot/M3WU07 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9685:ARMCX3 ^@ http://purl.uniprot.org/uniprot/M3X964 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9685:SULT1C3 ^@ http://purl.uniprot.org/uniprot/M3X2S6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9685:POLR2J ^@ http://purl.uniprot.org/uniprot/A0A2I2U599 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/9685:WASHC3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XE04 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9685:CEP44 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3F3 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/9685:PPIB ^@ http://purl.uniprot.org/uniprot/G3XEW6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9685:ELMO3 ^@ http://purl.uniprot.org/uniprot/A0A337SDU3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9685:CNN3 ^@ http://purl.uniprot.org/uniprot/M3WLX8 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9685:TSPAN1 ^@ http://purl.uniprot.org/uniprot/M3VUZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A2I2UM47|||http://purl.uniprot.org/uniprot/M3XAC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9685:UTP3 ^@ http://purl.uniprot.org/uniprot/M3W7E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAS10 family.|||nucleolus http://togogenome.org/gene/9685:CARMIL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9685:KATNB1 ^@ http://purl.uniprot.org/uniprot/M3VYZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9685:THBS4 ^@ http://purl.uniprot.org/uniprot/M3W148 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SLC26A4 ^@ http://purl.uniprot.org/uniprot/A0A337SMB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sodium-independent transporter of chloride and iodide. http://togogenome.org/gene/9685:LOC101098821 ^@ http://purl.uniprot.org/uniprot/A0A337SR22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:FZD3 ^@ http://purl.uniprot.org/uniprot/M3X5H1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:TAF5L ^@ http://purl.uniprot.org/uniprot/M3W847 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9685:CUEDC2 ^@ http://purl.uniprot.org/uniprot/M3VWA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9C3|||http://purl.uniprot.org/uniprot/O62657 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells.|||Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of ACKR3. Interacts with integrin subunit ITGB3 (via the allosteric site (site 2)). Interacts with TNFAIP6 (via Link domain).|||Secreted http://togogenome.org/gene/9685:ZSCAN25 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:STK40 ^@ http://purl.uniprot.org/uniprot/M3W3R6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.|||Nucleus http://togogenome.org/gene/9685:AVPR1A ^@ http://purl.uniprot.org/uniprot/M3WKK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9685:CE2H19orf12 ^@ http://purl.uniprot.org/uniprot/A0A337SLN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/9685:MMP8 ^@ http://purl.uniprot.org/uniprot/M3WNA0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:ANKRD13B ^@ http://purl.uniprot.org/uniprot/M3VZ34 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9685:GASK1B ^@ http://purl.uniprot.org/uniprot/A0A2I2U5G6 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9685:HVCN1 ^@ http://purl.uniprot.org/uniprot/M3X2E4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9685:BCL2L11 ^@ http://purl.uniprot.org/uniprot/A0A337SPG0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Bcl-2 family.|||Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.|||Induces apoptosis and anoikis. http://togogenome.org/gene/9685:ESCO2 ^@ http://purl.uniprot.org/uniprot/M3WKP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:MINDY1 ^@ http://purl.uniprot.org/uniprot/M3WBV2 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9685:LOC101096260 ^@ http://purl.uniprot.org/uniprot/M3WIG2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101094129 ^@ http://purl.uniprot.org/uniprot/M3X2U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PA2G4 ^@ http://purl.uniprot.org/uniprot/M3WLH5 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/9685:CD28 ^@ http://purl.uniprot.org/uniprot/Q9N2I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GMFG ^@ http://purl.uniprot.org/uniprot/A0A2I2UH76 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9685:CYP26A1 ^@ http://purl.uniprot.org/uniprot/M3W7D6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9685:CDS1 ^@ http://purl.uniprot.org/uniprot/M3XA08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9685:SFRP4 ^@ http://purl.uniprot.org/uniprot/M3X0E0 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LOC101101656 ^@ http://purl.uniprot.org/uniprot/M3XBQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9685:ZNF18 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKL4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PRPS1 ^@ http://purl.uniprot.org/uniprot/A0A337SDM3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9685:ACBD5 ^@ http://purl.uniprot.org/uniprot/M3WGY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9685:ADAMTS15 ^@ http://purl.uniprot.org/uniprot/M3W9E9 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9685:LOC101097506 ^@ http://purl.uniprot.org/uniprot/M3WZG7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9685:SLC25A40 ^@ http://purl.uniprot.org/uniprot/A0A2I2UE31 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101091809 ^@ http://purl.uniprot.org/uniprot/A0A2I2U6J8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues. http://togogenome.org/gene/9685:CA5A ^@ http://purl.uniprot.org/uniprot/A0A337S4J0 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9685:SSRP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U684 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/9685:TNNI3 ^@ http://purl.uniprot.org/uniprot/Q863B6 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the troponin I family.|||Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1 (By similarity).|||Phosphorylated at Ser-22 and Ser-23 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity).|||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9685:HUS1 ^@ http://purl.uniprot.org/uniprot/M3XC14 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/9685:EXOG ^@ http://purl.uniprot.org/uniprot/M3VZU1 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9685:RAB21 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cleavage furrow|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||trans-Golgi network http://togogenome.org/gene/9685:RRM1 ^@ http://purl.uniprot.org/uniprot/M3W8F8 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/9685:VBP1 ^@ http://purl.uniprot.org/uniprot/M3WX04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9685:KCNA2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XTT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||lamellipodium membrane|||paranodal septate junction|||synaptosome http://togogenome.org/gene/9685:EIF3M ^@ http://purl.uniprot.org/uniprot/M3VUI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9685:EZH1 ^@ http://purl.uniprot.org/uniprot/M3WIA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PCYT1A ^@ http://purl.uniprot.org/uniprot/M3X9J4 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9685:TMEM256 ^@ http://purl.uniprot.org/uniprot/M3WSW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9685:LOC101098527 ^@ http://purl.uniprot.org/uniprot/A0A2I2UG93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:BAIAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0L4|||http://purl.uniprot.org/uniprot/A0A337S118 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.|||Membrane|||cytoskeleton|||filopodium|||ruffle http://togogenome.org/gene/9685:FAM149B1 ^@ http://purl.uniprot.org/uniprot/M3X367 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9685:SF3B5 ^@ http://purl.uniprot.org/uniprot/M3VVN9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/9685:OXSR1 ^@ http://purl.uniprot.org/uniprot/M3WGU7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9685:RFTN1 ^@ http://purl.uniprot.org/uniprot/M3WU48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:CBFA2T2 ^@ http://purl.uniprot.org/uniprot/A0A337S063 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/9685:UBE2C ^@ http://purl.uniprot.org/uniprot/M3VXG6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9685:OIP5 ^@ http://purl.uniprot.org/uniprot/A0A2I2V535 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/9685:MYO5C ^@ http://purl.uniprot.org/uniprot/M3WH72 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9685:ACHE ^@ http://purl.uniprot.org/uniprot/O62763 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers.|||Secreted|||Synapse|||Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. http://togogenome.org/gene/9685:RNASEH2A ^@ http://purl.uniprot.org/uniprot/M3VUU3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/9685:MICOS13 ^@ http://purl.uniprot.org/uniprot/M3WFV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:CDH15 ^@ http://purl.uniprot.org/uniprot/M3W1R7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SPI1 ^@ http://purl.uniprot.org/uniprot/M3VYP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:MTMR6 ^@ http://purl.uniprot.org/uniprot/A0A5F5XQ58|||http://purl.uniprot.org/uniprot/M3WY58 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9685:LOC101095347 ^@ http://purl.uniprot.org/uniprot/M3WSM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:PABPC4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9685:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNX1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:CEP19 ^@ http://purl.uniprot.org/uniprot/A0A337SIL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/9685:MEGF8 ^@ http://purl.uniprot.org/uniprot/A0A337RYD6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:KCNB2 ^@ http://purl.uniprot.org/uniprot/M3WH41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon|||dendrite http://togogenome.org/gene/9685:ENTPD1 ^@ http://purl.uniprot.org/uniprot/M3WJX1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9685:LOC101099146 ^@ http://purl.uniprot.org/uniprot/A0A5F5XRA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DNTTIP2 ^@ http://purl.uniprot.org/uniprot/M3X060 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9685:NDNF ^@ http://purl.uniprot.org/uniprot/M3WEB4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9685:MSX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:KALRN ^@ http://purl.uniprot.org/uniprot/A0A5F5XLT6|||http://purl.uniprot.org/uniprot/M3WWH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9685:CDK5RAP3 ^@ http://purl.uniprot.org/uniprot/M3WBA5 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/9685:EIF2B4 ^@ http://purl.uniprot.org/uniprot/A0A337S5G6|||http://purl.uniprot.org/uniprot/M3WM19 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9685:LOC100169654 ^@ http://purl.uniprot.org/uniprot/O19432 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9685:CE3H16orf58 ^@ http://purl.uniprot.org/uniprot/A0A337SA82|||http://purl.uniprot.org/uniprot/M3XBD1 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/9685:LOC101089133 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y3P7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101098057 ^@ http://purl.uniprot.org/uniprot/M3XBP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:QARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCN5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:PLCB4 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZA9 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9685:HOXD12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UDB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:EDN2 ^@ http://purl.uniprot.org/uniprot/Q5NRQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Endothelins are endothelium-derived vasoconstrictor peptides.|||Secreted http://togogenome.org/gene/9685:RRH ^@ http://purl.uniprot.org/uniprot/M3W437 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9685:DTX3L ^@ http://purl.uniprot.org/uniprot/M3VVN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9685:RHCG ^@ http://purl.uniprot.org/uniprot/M3WHT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9685:FCER1G ^@ http://purl.uniprot.org/uniprot/A0A2I2V145 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:TMEM229B ^@ http://purl.uniprot.org/uniprot/A0A5F5Y1W9|||http://purl.uniprot.org/uniprot/M3XDR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/9685:SGCZ ^@ http://purl.uniprot.org/uniprot/M3XFV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9685:TAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2URY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9685:GALNT15 ^@ http://purl.uniprot.org/uniprot/M3W5R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:NDUFA12 ^@ http://purl.uniprot.org/uniprot/M3WRN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:AOX1 ^@ http://purl.uniprot.org/uniprot/M1ZMQ7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9685:TLE1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIJ2|||http://purl.uniprot.org/uniprot/A0A337SUZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9685:CD9 ^@ http://purl.uniprot.org/uniprot/P40239 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (By similarity). Interacts with integrin ITGA6:ITGB1; interaction takes place in oocytes and is involved in sperm-egg fusion (By similarity). Part of integrin-tetraspanin complexes composed of CD81, beta-1 and beta-2 integrins in the membrane of monocyte/macrophages (By similarity). Interacts with CD63; identified in a complex with CD63 and ITGB3. Associates with CR2/CD21 and with PTGFRN/CD9P1. Part of a complex composed of CD9, CD81, PTGFRN and IGSF8 (By similarity). Interacts directly with IGSF8. Interacts with PDPN; this interaction is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Interacts (on T cell side) with CD81 at immunological synapses between antigen-presenting cells and T cells (By similarity).|||Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity).|||Membrane|||Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.|||extracellular exosome http://togogenome.org/gene/9685:VPS54 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/9685:PLA2G4D ^@ http://purl.uniprot.org/uniprot/A0A2I2U0T3 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9685:LTA4H ^@ http://purl.uniprot.org/uniprot/M3WNR5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/9685:RPS6KA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPE2|||http://purl.uniprot.org/uniprot/M3WHN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9685:PIGL ^@ http://purl.uniprot.org/uniprot/M3WE00 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/9685:FLVCR1 ^@ http://purl.uniprot.org/uniprot/Q9N1F2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ (Microbial infection) Confers susceptibility to Feline leukemia virus subgroup C (FeLV-C) infection, which is associated with fatal erythroid aplasia, also known as aplastic anemia (PubMed:10648427).|||Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.|||Cell membrane|||Heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies. Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated.|||Interacts with HPX.|||N-Glycosylated. http://togogenome.org/gene/9685:BSX ^@ http://purl.uniprot.org/uniprot/M3W5J1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CD164L2 ^@ http://purl.uniprot.org/uniprot/A0A337S0G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9685:IL10 ^@ http://purl.uniprot.org/uniprot/P55029 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-10 family.|||Homodimer. Interacts with IL10RA and IL10RB.|||Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).|||Secreted http://togogenome.org/gene/9685:DNTTIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZ74 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:BORA ^@ http://purl.uniprot.org/uniprot/M3WCM8 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/9685:EIF3J ^@ http://purl.uniprot.org/uniprot/A0A337SFB5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit J family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9685:TMEM87B ^@ http://purl.uniprot.org/uniprot/M3W8Y4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:SLC25A31 ^@ http://purl.uniprot.org/uniprot/M3W759 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9685:SNRNP200 ^@ http://purl.uniprot.org/uniprot/A0A2I2UID1 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/9685:ARHGEF9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UV58 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|||Cytoplasm|||Interacts with GPHN.|||Postsynaptic density http://togogenome.org/gene/9685:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5Y7|||http://purl.uniprot.org/uniprot/A0A2I2ULX5|||http://purl.uniprot.org/uniprot/M3WJ75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9685:RNPS1 ^@ http://purl.uniprot.org/uniprot/A0A337S532|||http://purl.uniprot.org/uniprot/A0A337SJJ9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus speckle http://togogenome.org/gene/9685:GPR39 ^@ http://purl.uniprot.org/uniprot/M3VTY6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:LOC101081204 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9685:AOC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0U5 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9685:LSM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3Z1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/9685:MYOG ^@ http://purl.uniprot.org/uniprot/A0A2I2U9I7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:HSPA4L ^@ http://purl.uniprot.org/uniprot/M3W9Y3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9685:LOC101080959 ^@ http://purl.uniprot.org/uniprot/M3X958 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CFAP107 ^@ http://purl.uniprot.org/uniprot/M3X9H2 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9685:TMEM63B ^@ http://purl.uniprot.org/uniprot/A0A2I2UAS1|||http://purl.uniprot.org/uniprot/M3WC22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9685:ACO2 ^@ http://purl.uniprot.org/uniprot/M3WP87 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/9685:HMGB2 ^@ http://purl.uniprot.org/uniprot/M3W1S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9685:CRYGA ^@ http://purl.uniprot.org/uniprot/M3W1B5 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:NUPR1 ^@ http://purl.uniprot.org/uniprot/M3WGP0 ^@ Similarity ^@ Belongs to the NUPR family. http://togogenome.org/gene/9685:UCK2 ^@ http://purl.uniprot.org/uniprot/M3WW08 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9685:OCLN ^@ http://purl.uniprot.org/uniprot/M3W874 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/9685:MAPRE2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNL9|||http://purl.uniprot.org/uniprot/A0A337SIM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9685:MSH6 ^@ http://purl.uniprot.org/uniprot/M3W729 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/9685:LOC101089895 ^@ http://purl.uniprot.org/uniprot/A0A5F5XV57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101095695 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CLK4 ^@ http://purl.uniprot.org/uniprot/M3WQC0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:SLC7A9 ^@ http://purl.uniprot.org/uniprot/M3WLL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RPL9 ^@ http://purl.uniprot.org/uniprot/M3WGN1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/9685:SFR1 ^@ http://purl.uniprot.org/uniprot/M3XBS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/9685:ALG2 ^@ http://purl.uniprot.org/uniprot/M3X7Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/9685:TMEM183A ^@ http://purl.uniprot.org/uniprot/M3WI85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM183 family.|||Membrane http://togogenome.org/gene/9685:ATG4A ^@ http://purl.uniprot.org/uniprot/M3W3M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9685:CDC73 ^@ http://purl.uniprot.org/uniprot/M3VUK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC73 family.|||Nucleus http://togogenome.org/gene/9685:DYNLT2B ^@ http://purl.uniprot.org/uniprot/M3X1Q3 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9685:DPH6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIY9|||http://purl.uniprot.org/uniprot/M3WC98 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/9685:GPRIN3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XF41 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9685:WDR83OS ^@ http://purl.uniprot.org/uniprot/M3VUT6 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/9685:AP1M1 ^@ http://purl.uniprot.org/uniprot/M3WAM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9685:MCP-1 ^@ http://purl.uniprot.org/uniprot/M3VVI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:ITM2A ^@ http://purl.uniprot.org/uniprot/A0A5F5XX48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9685:RRP12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUU0 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/9685:AP3B1 ^@ http://purl.uniprot.org/uniprot/M3X1N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9685:LOC101088952 ^@ http://purl.uniprot.org/uniprot/A0A337S5E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DPM1 ^@ http://purl.uniprot.org/uniprot/M3WC50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/9685:NPY2R ^@ http://purl.uniprot.org/uniprot/A0A2I2V4M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PHKA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPH9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9685:MMP1 ^@ http://purl.uniprot.org/uniprot/M3WNA1 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:NKAPL ^@ http://purl.uniprot.org/uniprot/M3WUU0 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9685:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/M3XB56 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9685:CCDC90B ^@ http://purl.uniprot.org/uniprot/M3X851 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9685:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UMS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9685:CDH3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UB75|||http://purl.uniprot.org/uniprot/M3VVY0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:DBT ^@ http://purl.uniprot.org/uniprot/M3XBZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9685:IFNA5 ^@ http://purl.uniprot.org/uniprot/Q8MIL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9685:ACAD8 ^@ http://purl.uniprot.org/uniprot/M3W7P8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9685:PI4KA ^@ http://purl.uniprot.org/uniprot/A0A2I2UFV3 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9685:LOC101080886 ^@ http://purl.uniprot.org/uniprot/M3XAW8 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:MYC ^@ http://purl.uniprot.org/uniprot/D3U662|||http://purl.uniprot.org/uniprot/P68271 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity). Interacts with CIP2A; leading to the stabilization of MYC (By similarity).|||Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).|||The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.|||Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9685:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A337SL12|||http://purl.uniprot.org/uniprot/A0A337SW96|||http://purl.uniprot.org/uniprot/A0A337SWA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9685:IL11RA ^@ http://purl.uniprot.org/uniprot/A0A2I2V0P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily.|||Cell membrane http://togogenome.org/gene/9685:LOC101091338 ^@ http://purl.uniprot.org/uniprot/M3WBG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:AAR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGH2 ^@ Function|||Similarity ^@ Belongs to the AAR2 family.|||Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. http://togogenome.org/gene/9685:FGF5 ^@ http://purl.uniprot.org/uniprot/A0A5F5XXT0|||http://purl.uniprot.org/uniprot/M3X9S6 ^@ Function|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Allelic variations in FGF5 may be associated with long-haired phenotype in domestic cats. The trait is autosomal recessive.|||Belongs to the heparin-binding growth factors family.|||Expressed in skin.|||Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.|||Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).|||Secreted http://togogenome.org/gene/9685:SPIB ^@ http://purl.uniprot.org/uniprot/A0A2I2UH83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:AFP ^@ http://purl.uniprot.org/uniprot/M3X557 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9685:NSUN4 ^@ http://purl.uniprot.org/uniprot/A0A337RW22|||http://purl.uniprot.org/uniprot/A0A5F5Y272 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9685:SPTLC2 ^@ http://purl.uniprot.org/uniprot/M3VX05 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9685:WDR82 ^@ http://purl.uniprot.org/uniprot/M3X596 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/9685:SENP3 ^@ http://purl.uniprot.org/uniprot/M3WBR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/9685:TENT5D ^@ http://purl.uniprot.org/uniprot/M3X0P8 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9685:SLC5A7 ^@ http://purl.uniprot.org/uniprot/M3VWH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PDGFRA ^@ http://purl.uniprot.org/uniprot/M3WAV8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/9685:SMARCA4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UID9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9685:TMEM59L ^@ http://purl.uniprot.org/uniprot/M3WC16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:UCP2 ^@ http://purl.uniprot.org/uniprot/M3W3C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:SMG7 ^@ http://purl.uniprot.org/uniprot/A0A337SBW8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9685:SFXN5 ^@ http://purl.uniprot.org/uniprot/A0A337S7F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9685:MINDY4 ^@ http://purl.uniprot.org/uniprot/M3WF31 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9685:FMR1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XJT1|||http://purl.uniprot.org/uniprot/M3W7C6|||http://purl.uniprot.org/uniprot/M3WUC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Stress granule|||Synapse|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/9685:OGDH ^@ http://purl.uniprot.org/uniprot/A0A337RVJ8|||http://purl.uniprot.org/uniprot/A0A337SRK5|||http://purl.uniprot.org/uniprot/A0A337SVV8|||http://purl.uniprot.org/uniprot/M3WCZ2 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9685:RORB ^@ http://purl.uniprot.org/uniprot/A0A2I2UKU6|||http://purl.uniprot.org/uniprot/M3WF32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9685:MFN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8C5 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:LOC101091533 ^@ http://purl.uniprot.org/uniprot/A0A5F5XI95 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:NDEL1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XKV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/9685:CHMP2A ^@ http://purl.uniprot.org/uniprot/M3W0W8 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9685:DMC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWH9|||http://purl.uniprot.org/uniprot/A0A337SB76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/9685:BCKDHA ^@ http://purl.uniprot.org/uniprot/M3W423 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. http://togogenome.org/gene/9685:EML1 ^@ http://purl.uniprot.org/uniprot/M3W2K9 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9685:NPRL2 ^@ http://purl.uniprot.org/uniprot/M3VXQ0 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/9685:GOSR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U368 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9685:TGFB1 ^@ http://purl.uniprot.org/uniprot/M3W421 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||extracellular matrix http://togogenome.org/gene/9685:STAC ^@ http://purl.uniprot.org/uniprot/M3W3A8 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9685:NOTCH2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0T9|||http://purl.uniprot.org/uniprot/A0A2I2UD82 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/9685:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A337STZ1|||http://purl.uniprot.org/uniprot/M3WFV6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:EWSR1 ^@ http://purl.uniprot.org/uniprot/A0A337ST85|||http://purl.uniprot.org/uniprot/A0A337STI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9685:SYT1 ^@ http://purl.uniprot.org/uniprot/A0A337STW9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/9685:CAMK1D ^@ http://purl.uniprot.org/uniprot/A0A5F5XXT7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:RIOK2 ^@ http://purl.uniprot.org/uniprot/M3X9L1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9685:LOC101091225 ^@ http://purl.uniprot.org/uniprot/M3XFH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CPSF3 ^@ http://purl.uniprot.org/uniprot/M3W8I0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:HOXC11 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9685:ULK3 ^@ http://purl.uniprot.org/uniprot/M3W121 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:IFI6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9685:SLC52A2 ^@ http://purl.uniprot.org/uniprot/M3W888 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9685:LOC101095392 ^@ http://purl.uniprot.org/uniprot/M3WBI8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:KEF43_p02 ^@ http://purl.uniprot.org/uniprot/A0A0R8CB67|||http://purl.uniprot.org/uniprot/P48926 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 6 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9685:GINS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UG70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9685:CRYBB1 ^@ http://purl.uniprot.org/uniprot/M3WDS8 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:DDX5 ^@ http://purl.uniprot.org/uniprot/M3W0H3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/9685:CASKIN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UD46 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9685:AZIN1 ^@ http://purl.uniprot.org/uniprot/M3WCK7 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9685:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A337S7R8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:ARCN1 ^@ http://purl.uniprot.org/uniprot/M3WFS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9685:SMG9 ^@ http://purl.uniprot.org/uniprot/A0A337S2M1 ^@ Similarity ^@ Belongs to the SMG9 family. http://togogenome.org/gene/9685:GAS8 ^@ http://purl.uniprot.org/uniprot/A0A5F5XV85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9685:SLC16A5 ^@ http://purl.uniprot.org/uniprot/M3WKU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9685:VIPAS39 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y0Q2 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Early endosome|||Endosome|||Late endosome|||Vesicle http://togogenome.org/gene/9685:MIX23 ^@ http://purl.uniprot.org/uniprot/M3X245 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9685:EIF4EBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNS0 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9685:PFKFB1 ^@ http://purl.uniprot.org/uniprot/A0A337S3U5|||http://purl.uniprot.org/uniprot/A0A337SUA4|||http://purl.uniprot.org/uniprot/M3VVL9 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9685:POU4F2 ^@ http://purl.uniprot.org/uniprot/M3VZM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9685:MID1 ^@ http://purl.uniprot.org/uniprot/M3VYS6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:WT1 ^@ http://purl.uniprot.org/uniprot/A0A337S500 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9685:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/M3WNQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9685:PLSCR3 ^@ http://purl.uniprot.org/uniprot/M3WE53 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9685:FPGS ^@ http://purl.uniprot.org/uniprot/A0A337ST19 ^@ Cofactor|||Function|||Similarity ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. http://togogenome.org/gene/9685:TMEM167B ^@ http://purl.uniprot.org/uniprot/A0A2I2V282 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:PELO ^@ http://purl.uniprot.org/uniprot/A0A2I2UYB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.|||Cytoplasm http://togogenome.org/gene/9685:STEEP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UND2|||http://purl.uniprot.org/uniprot/A0A337S0X6 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9685:RASSF5 ^@ http://purl.uniprot.org/uniprot/A0A337SG02 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:DOCK1 ^@ http://purl.uniprot.org/uniprot/M3W9G8 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9685:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2US39 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9685:CCL16 ^@ http://purl.uniprot.org/uniprot/M3WCI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:SPARC ^@ http://purl.uniprot.org/uniprot/M3W550 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9685:RIPK2 ^@ http://purl.uniprot.org/uniprot/M3WPQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.|||Cytoplasm|||Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.|||Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. http://togogenome.org/gene/9685:MAML2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/9685:ESRRB ^@ http://purl.uniprot.org/uniprot/A0A5F5Y5D6|||http://purl.uniprot.org/uniprot/M3WAK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9685:HADHB ^@ http://purl.uniprot.org/uniprot/M3WLM4 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9685:IDS ^@ http://purl.uniprot.org/uniprot/M3WZT0 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9685:CYBA ^@ http://purl.uniprot.org/uniprot/M3W6A1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p22phox family.|||Cell membrane|||Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).|||Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.|||Membrane http://togogenome.org/gene/9685:SMPDL3A ^@ http://purl.uniprot.org/uniprot/M3WFD8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9685:WNT10A ^@ http://purl.uniprot.org/uniprot/A0A2I2U6E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9685:SLC2A9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane http://togogenome.org/gene/9685:AQP4 ^@ http://purl.uniprot.org/uniprot/A0A337SLX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:MED13 ^@ http://purl.uniprot.org/uniprot/M3WLK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:TPD52L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U356|||http://purl.uniprot.org/uniprot/A0A2I2UBL6|||http://purl.uniprot.org/uniprot/A0A337S938|||http://purl.uniprot.org/uniprot/A0A5F5XEW5|||http://purl.uniprot.org/uniprot/M3VW51 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9685:HSD17B13 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEH6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:IL1B ^@ http://purl.uniprot.org/uniprot/P41687 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling. Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form. Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC. Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9685:HSCB ^@ http://purl.uniprot.org/uniprot/A0A2I2U3M8|||http://purl.uniprot.org/uniprot/A0A337SF44 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/9685:DBR1 ^@ http://purl.uniprot.org/uniprot/M3WYY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/9685:ATP6V1G2 ^@ http://purl.uniprot.org/uniprot/A0A337S9H0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9685:PNPLA4 ^@ http://purl.uniprot.org/uniprot/M3W1J2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UDR2|||http://purl.uniprot.org/uniprot/A0A337RZB4|||http://purl.uniprot.org/uniprot/A0A337STQ7|||http://purl.uniprot.org/uniprot/A0A337SU86|||http://purl.uniprot.org/uniprot/M3WMQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/9685:LOC102899183 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:NEUROD1 ^@ http://purl.uniprot.org/uniprot/M3W2E4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CMBL ^@ http://purl.uniprot.org/uniprot/M3X3U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9685:IRF5 ^@ http://purl.uniprot.org/uniprot/M3VVQ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:GKAP1 ^@ http://purl.uniprot.org/uniprot/M3X912 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/9685:NR0B1 ^@ http://purl.uniprot.org/uniprot/M3WQZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus|||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. http://togogenome.org/gene/9685:NPY5R ^@ http://purl.uniprot.org/uniprot/M3XA14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. http://togogenome.org/gene/9685:ESF1 ^@ http://purl.uniprot.org/uniprot/M3WZT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/9685:LOC101081808 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZ66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:RPS6KA5 ^@ http://purl.uniprot.org/uniprot/M3VWX0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9685:ACSL4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UET1|||http://purl.uniprot.org/uniprot/A0A5K1UM18 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:ACER2 ^@ http://purl.uniprot.org/uniprot/M3VYQ1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:HSP90B1 ^@ http://purl.uniprot.org/uniprot/M3WK11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9685:SYT17 ^@ http://purl.uniprot.org/uniprot/A0A2I2UM18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/9685:MAN2B1 ^@ http://purl.uniprot.org/uniprot/O46432 ^@ Cofactor|||Disease Annotation|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit.|||Defects in MAN2B1 are the cause of lysosomal alpha-mannosidosis (AM). AM is a lysosomal storage disease characterized by accumulation of unbranched oligosaccharide chains.|||Lysosome|||Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.|||Processed into 3 peptides of 72 kDa, 41 kDa and 12 kDa. http://togogenome.org/gene/9685:EDEM2 ^@ http://purl.uniprot.org/uniprot/M3VYA1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9685:SLC1A2 ^@ http://purl.uniprot.org/uniprot/Q9BDJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9685:CMTR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4S4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with POLR2A (via C-terminus).|||Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/9685:ADAM2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHG7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LOC101080954 ^@ http://purl.uniprot.org/uniprot/A0A2I2UH17 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9685:LOC101088902 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVG5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9685:CLNS1A ^@ http://purl.uniprot.org/uniprot/M3XFV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/9685:AHR ^@ http://purl.uniprot.org/uniprot/M3W3B4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:OPALIN ^@ http://purl.uniprot.org/uniprot/A0A2I2USJ5|||http://purl.uniprot.org/uniprot/A0A337S6H1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.|||Membrane http://togogenome.org/gene/9685:BEND6 ^@ http://purl.uniprot.org/uniprot/M3VVQ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CA7 ^@ http://purl.uniprot.org/uniprot/M3WHK2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9685:LOC101084866 ^@ http://purl.uniprot.org/uniprot/M3X1R4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9685:SNAPIN ^@ http://purl.uniprot.org/uniprot/M3W934 ^@ Similarity ^@ Belongs to the SNAPIN family. http://togogenome.org/gene/9685:AK2 ^@ http://purl.uniprot.org/uniprot/A0A337SDR5|||http://purl.uniprot.org/uniprot/A0A337SGU6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9685:LOC101083355 ^@ http://purl.uniprot.org/uniprot/M3WZ94 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9685:H1-6 ^@ http://purl.uniprot.org/uniprot/M3W524 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9685:PNPT1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XS63|||http://purl.uniprot.org/uniprot/M3WIH2 ^@ Similarity ^@ Belongs to the polyribonucleotide nucleotidyltransferase family. http://togogenome.org/gene/9685:PACC1 ^@ http://purl.uniprot.org/uniprot/M3WL04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:KCNJ3 ^@ http://purl.uniprot.org/uniprot/M3XFS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/9685:FELCATV1R16 ^@ http://purl.uniprot.org/uniprot/M3WW21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBM6|||http://purl.uniprot.org/uniprot/M3X8V0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:FAM72A ^@ http://purl.uniprot.org/uniprot/A0A2I2UAK6|||http://purl.uniprot.org/uniprot/A0A337SFG5 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/9685:LOC105260538 ^@ http://purl.uniprot.org/uniprot/M3WSM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:ASIC4 ^@ http://purl.uniprot.org/uniprot/M3W6A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/9685:GDPD3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XDL4|||http://purl.uniprot.org/uniprot/M3XAE5 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9685:LDAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/9685:ALPL ^@ http://purl.uniprot.org/uniprot/Q29486 ^@ Activity Regulation|||Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis. Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates. Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration. Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix. Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner. Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters. Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (By similarity). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity).|||Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Calcium-binding is structural and does not influence the alkaline phosphatase activity. At very high concentrations, calcium can however substitute for zinc at zinc-binding sites, leading to strongly reduced enzyme activity.|||Cell membrane|||Extracellular vesicle membrane|||Homodimer.|||Mitochondrion intermembrane space|||Mitochondrion membrane|||N-glycosylated.|||Phosphatase activity is specifically inhibited by 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425). http://togogenome.org/gene/9685:MPDU1 ^@ http://purl.uniprot.org/uniprot/A0A337SJN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane|||Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors. http://togogenome.org/gene/9685:RDH11 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y685|||http://purl.uniprot.org/uniprot/M3WK22 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:CDO1 ^@ http://purl.uniprot.org/uniprot/M3WPX5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/9685:TCTA ^@ http://purl.uniprot.org/uniprot/M3WUV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane http://togogenome.org/gene/9685:ABCB6 ^@ http://purl.uniprot.org/uniprot/M3WEQ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Late endosome membrane|||Lysosome membrane|||Melanosome membrane|||Membrane|||Mitochondrion outer membrane|||extracellular exosome|||multivesicular body membrane http://togogenome.org/gene/9685:CELSR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7Y3|||http://purl.uniprot.org/uniprot/A0A5F5XJ86|||http://purl.uniprot.org/uniprot/M3WM93 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor that may have an important role in cell/cell signaling during nervous system formation. http://togogenome.org/gene/9685:ACTL7B ^@ http://purl.uniprot.org/uniprot/M3WY90 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:SPTLC3 ^@ http://purl.uniprot.org/uniprot/M3WKG1 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9685:COG8 ^@ http://purl.uniprot.org/uniprot/M3WJ31 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG8 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:SH3BGRL ^@ http://purl.uniprot.org/uniprot/M3X5I6 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9685:TBC1D31 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTP2 ^@ Function|||Subcellular Location Annotation ^@ Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.|||centriolar satellite|||cilium basal body http://togogenome.org/gene/9685:GAST ^@ http://purl.uniprot.org/uniprot/A0A0A0MQ11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.|||Secreted http://togogenome.org/gene/9685:SLC44A4 ^@ http://purl.uniprot.org/uniprot/M3W2B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9685:SEC61G ^@ http://purl.uniprot.org/uniprot/A0A2I2UKG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:GJB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V1B3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:B3GALT9 ^@ http://purl.uniprot.org/uniprot/M3XCM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:MFAP5 ^@ http://purl.uniprot.org/uniprot/M3WRG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/9685:CLDN6 ^@ http://purl.uniprot.org/uniprot/M3W2L0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:MB ^@ http://purl.uniprot.org/uniprot/M3WCL7 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9685:AK6 ^@ http://purl.uniprot.org/uniprot/M3X272 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/9685:HSPB6 ^@ http://purl.uniprot.org/uniprot/M3W5U0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small heat shock protein (HSP20) family.|||Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.|||Cytoplasm|||Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.|||Nucleus http://togogenome.org/gene/9685:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/M3W836 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:SLC66A1 ^@ http://purl.uniprot.org/uniprot/M3WA77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PDE1B ^@ http://purl.uniprot.org/uniprot/A0A2I2UT70 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:RPRD1B ^@ http://purl.uniprot.org/uniprot/M3X7W3 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9685:HGD ^@ http://purl.uniprot.org/uniprot/M3XF73 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/9685:PSMB6 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3F3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:INA ^@ http://purl.uniprot.org/uniprot/M3WWQ5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:UGCG ^@ http://purl.uniprot.org/uniprot/M3X3K9 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9685:GPR141 ^@ http://purl.uniprot.org/uniprot/M3WME9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101097515 ^@ http://purl.uniprot.org/uniprot/M3WW58 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CNR1 ^@ http://purl.uniprot.org/uniprot/O02777 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Expressed in cerebral arterial muscle cells and cerebral cortex (at protein level).|||G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system, including NDUFS2. In the hypothalamus, inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids, drives the release of orexigenic beta-endorphin, not that of melanocyte-stimulating hormone alpha/alpha-MSH, from hypothalamic POMC neurons, hence promoting food intake. In the hippocampus, regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI), a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells, inhibits voltage-gated Ca(2+) channels in a constitutive, as well as agonist-dependent manner (PubMed:10362691). In cerebral vascular smooth muscle cells, inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decrease in vascular tone (PubMed:10362691). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney, hence participating in hyperleptinemia. In adipose tissue, CNR1 signaling leads to increased expression of SREBF1, ACACA and FASN genes. In the liver, activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism, associated with increased expression of SREBF1/SREBP-1, GCK, ACACA, ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism. In high carbohydrate diet-induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles, as well as that of selected glucose/ pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism. In response to cannabinoid anandamide, elicits a pro-inflammatory response in macrophages, which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets, this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (By similarity).|||Hemopressin, a peptide derived from hemoglobin subunit alpha (HBA1 and/or HBA2), acts as an antagonist peptide: hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.|||Interacts (via C-terminus) with CNRIP1; this interaction attenuates constitutive, but not agonist-dependent, inhibition of voltage-gated Ca(2+) channels in neurons (By similarity). Associates with G protein alpha subunits, including G(i) alpha-1/GNAI1, G(i) alpha-3/GNAI3 and G(o)-alpha/GNAO1; palmitoylation is important for interaction with GNAI3 and GNAO1 (By similarity).|||Membrane raft|||Mitochondrion outer membrane|||Palmitoylation at Cys-415 is important for recruitment at plasma membrane and lipid rafts and association with G protein alpha subunits.|||Presynapse|||axon http://togogenome.org/gene/9685:LOC101099090 ^@ http://purl.uniprot.org/uniprot/M3WFJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9685:RTRAF ^@ http://purl.uniprot.org/uniprot/M3VYX1 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/9685:NUDT21 ^@ http://purl.uniprot.org/uniprot/M3WA00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/9685:CYP2R1 ^@ http://purl.uniprot.org/uniprot/M3WF06 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9685:ZAR1L ^@ http://purl.uniprot.org/uniprot/A0A2I2V276|||http://purl.uniprot.org/uniprot/A0A5F5XPM3 ^@ Similarity|||Subunit ^@ Belongs to the ZAR1 family.|||Interacts with YBX2. http://togogenome.org/gene/9685:TUBB2B ^@ http://purl.uniprot.org/uniprot/A0A2I2UXF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9685:CGA ^@ http://purl.uniprot.org/uniprot/Q52R91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Secreted|||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. http://togogenome.org/gene/9685:MOGAT2 ^@ http://purl.uniprot.org/uniprot/M3W2J6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:GNG14 ^@ http://purl.uniprot.org/uniprot/M3X5V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9685:ZC2HC1C ^@ http://purl.uniprot.org/uniprot/A0A5F5XZF1 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/9685:MTFR1L ^@ http://purl.uniprot.org/uniprot/A0A337SAW9|||http://purl.uniprot.org/uniprot/M3WHL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9685:RBBP7 ^@ http://purl.uniprot.org/uniprot/M3X1K3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:FTSJ3 ^@ http://purl.uniprot.org/uniprot/M3WJV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Interacts with NIP7.|||Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.|||nucleolus http://togogenome.org/gene/9685:YIF1A ^@ http://purl.uniprot.org/uniprot/M3WB69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9685:LOC101091896 ^@ http://purl.uniprot.org/uniprot/M3WWF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SLC30A5 ^@ http://purl.uniprot.org/uniprot/M3W954 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9685:DOK4 ^@ http://purl.uniprot.org/uniprot/M3W2N6 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9685:HOXC12 ^@ http://purl.uniprot.org/uniprot/M3X3D7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:GLO1 ^@ http://purl.uniprot.org/uniprot/M3X4B1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/9685:CHST9 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3V3|||http://purl.uniprot.org/uniprot/A0A2I2UMT5|||http://purl.uniprot.org/uniprot/A0A337SK30|||http://purl.uniprot.org/uniprot/M3VZS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:CAPZA3 ^@ http://purl.uniprot.org/uniprot/M3W7D2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9685:RAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIN3|||http://purl.uniprot.org/uniprot/M3XB73 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9685:IQCD ^@ http://purl.uniprot.org/uniprot/M3X8D7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/9685:LOC101096635 ^@ http://purl.uniprot.org/uniprot/M3X4A2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:REM2 ^@ http://purl.uniprot.org/uniprot/M3W684 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:CMTM5 ^@ http://purl.uniprot.org/uniprot/A0A337S332|||http://purl.uniprot.org/uniprot/A0A337SJY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ERG28 ^@ http://purl.uniprot.org/uniprot/M3WK97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:DIO1 ^@ http://purl.uniprot.org/uniprot/Q6V915 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the iodothyronine deiodinase family.|||Endoplasmic reticulum membrane|||Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. http://togogenome.org/gene/9685:LOC101099980 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TYMS ^@ http://purl.uniprot.org/uniprot/M3WB14 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/9685:CEMIP2 ^@ http://purl.uniprot.org/uniprot/M3WDM4 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9685:SELE ^@ http://purl.uniprot.org/uniprot/A0A2I2TZY2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:YPEL4 ^@ http://purl.uniprot.org/uniprot/A0A2I2V302 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9685:NOVA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUY1|||http://purl.uniprot.org/uniprot/A0A337SFQ8|||http://purl.uniprot.org/uniprot/M3W1T2 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with PTBP2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9685:LOC105259687 ^@ http://purl.uniprot.org/uniprot/A0A337RVC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:HARBI1 ^@ http://purl.uniprot.org/uniprot/M3WSI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9685:NOC2L ^@ http://purl.uniprot.org/uniprot/M3W071 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/9685:PSME3 ^@ http://purl.uniprot.org/uniprot/A0A337SKZ6 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9685:RPS7 ^@ http://purl.uniprot.org/uniprot/Q5RT64 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Binds IPO9 with high affinity. Interacts with NEK6. Interacts with DESI2. Interacts with IPO5, IPO7 and KPNB1; these interactions may be involved in RPS7 nuclear import for the assembly of ribosomal subunits.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||Cytoplasm|||Phosphorylated by NEK6.|||centrosome|||nucleolus http://togogenome.org/gene/9685:NIBAN2 ^@ http://purl.uniprot.org/uniprot/M3VWQ9 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/9685:EPCAM ^@ http://purl.uniprot.org/uniprot/M3WIV4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.|||Membrane|||tight junction http://togogenome.org/gene/9685:CADM1 ^@ http://purl.uniprot.org/uniprot/A0A337SBC7 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9685:AGO1 ^@ http://purl.uniprot.org/uniprot/M3VVB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/9685:TIMM22 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2J5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:PIGF ^@ http://purl.uniprot.org/uniprot/M3WMX8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:FELCATV1R14 ^@ http://purl.uniprot.org/uniprot/M3WW79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PPP1R11 ^@ http://purl.uniprot.org/uniprot/A0A2I2UM79 ^@ Subunit ^@ Interacts with TLR2 and UBE2D2. http://togogenome.org/gene/9685:IMPDH2 ^@ http://purl.uniprot.org/uniprot/M3WC84 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/9685:ETFRF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPJ5 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9685:RPS20 ^@ http://purl.uniprot.org/uniprot/M3XBC9 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9685:NAT10 ^@ http://purl.uniprot.org/uniprot/M3VXR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with THUMPD1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/9685:SRFBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHN1 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/9685:INPP5A ^@ http://purl.uniprot.org/uniprot/M3WE58 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/9685:AMPD2 ^@ http://purl.uniprot.org/uniprot/A0A337S5I4|||http://purl.uniprot.org/uniprot/A0A337STM7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9685:TMCO5A ^@ http://purl.uniprot.org/uniprot/M3WKV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GABRA2 ^@ http://purl.uniprot.org/uniprot/A0A337SQD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9685:BEST1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XG26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9685:LLPH ^@ http://purl.uniprot.org/uniprot/M3X158 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9685:GALNTL6 ^@ http://purl.uniprot.org/uniprot/M3W8Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:CDK8 ^@ http://purl.uniprot.org/uniprot/M3WW64 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:ELF3 ^@ http://purl.uniprot.org/uniprot/M3VUS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:SOX14 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9L9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ABLIM3 ^@ http://purl.uniprot.org/uniprot/A0A337S4L1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:PDK3 ^@ http://purl.uniprot.org/uniprot/A0A337RZ08|||http://purl.uniprot.org/uniprot/M3VXY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9685:LOC101093577 ^@ http://purl.uniprot.org/uniprot/M3X4M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NONO ^@ http://purl.uniprot.org/uniprot/M3WLD5 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9685:PSMD2 ^@ http://purl.uniprot.org/uniprot/M3W8D9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9685:RNMT ^@ http://purl.uniprot.org/uniprot/M3WPI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/9685:SV2B ^@ http://purl.uniprot.org/uniprot/M3WZW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9685:LOC101100855 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFI3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:NETO1 ^@ http://purl.uniprot.org/uniprot/M3WLT3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:VPS52 ^@ http://purl.uniprot.org/uniprot/M3W1E1 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/9685:RENBP ^@ http://purl.uniprot.org/uniprot/M3WNP8 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/9685:NUDT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UU60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:C6 ^@ http://purl.uniprot.org/uniprot/M3WLH3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:IBSP ^@ http://purl.uniprot.org/uniprot/A0A2I2UBD2 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9685:SART1 ^@ http://purl.uniprot.org/uniprot/A0A337SQI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNU66/SART1 family.|||Nucleus http://togogenome.org/gene/9685:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/M3WH95 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/9685:MS4A7 ^@ http://purl.uniprot.org/uniprot/M3W7D8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9685:LLGL1 ^@ http://purl.uniprot.org/uniprot/M3WMK1 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/9685:HOXC5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9685:FOXO4 ^@ http://purl.uniprot.org/uniprot/M3WZ98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:DEF8 ^@ http://purl.uniprot.org/uniprot/A0A337SHB6 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/9685:UBA52 ^@ http://purl.uniprot.org/uniprot/P63052 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.|||Cytoplasm|||Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.|||Nucleus|||Part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).|||Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.|||Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. http://togogenome.org/gene/9685:BBS5 ^@ http://purl.uniprot.org/uniprot/A0A2I2U646|||http://purl.uniprot.org/uniprot/A0A5F5XJR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBS5 family.|||Membrane|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/9685:MFAP3 ^@ http://purl.uniprot.org/uniprot/M3X646 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:DDX41 ^@ http://purl.uniprot.org/uniprot/M3VWU8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/9685:NOX4 ^@ http://purl.uniprot.org/uniprot/M3XET3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PTH ^@ http://purl.uniprot.org/uniprot/Q9GL67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Interacts with PTH1R (via N-terminal extracellular domain).|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).|||Secreted http://togogenome.org/gene/9685:GABRA5 ^@ http://purl.uniprot.org/uniprot/M3WG25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:FGF21 ^@ http://purl.uniprot.org/uniprot/A0A7U3JWC1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9685:LOC101099246 ^@ http://purl.uniprot.org/uniprot/M3XF49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:UBE2L6 ^@ http://purl.uniprot.org/uniprot/M3XBX1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9685:PRICKLE3 ^@ http://purl.uniprot.org/uniprot/M3WVY2 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9685:GPR50 ^@ http://purl.uniprot.org/uniprot/A0A337S2D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PRDX2 ^@ http://purl.uniprot.org/uniprot/M3VUU2 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9685:LOC101091306 ^@ http://purl.uniprot.org/uniprot/M3X6M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SCAMP2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y5X9|||http://purl.uniprot.org/uniprot/M3VUL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9685:GJB1 ^@ http://purl.uniprot.org/uniprot/A0A654IFD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:TMEM165 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/9685:LOC101087152 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHY9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SLC4A7 ^@ http://purl.uniprot.org/uniprot/M3XDR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LMLN ^@ http://purl.uniprot.org/uniprot/A0A337SKC2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9685:RGS9 ^@ http://purl.uniprot.org/uniprot/M3WMH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CDK1 ^@ http://purl.uniprot.org/uniprot/M3WLP7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:CCDC65 ^@ http://purl.uniprot.org/uniprot/A0A337SLJ8 ^@ Subcellular Location Annotation ^@ flagellum axoneme http://togogenome.org/gene/9685:HOXA3 ^@ http://purl.uniprot.org/uniprot/M3X946 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9685:ATAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZN6|||http://purl.uniprot.org/uniprot/A0A337S138|||http://purl.uniprot.org/uniprot/M3W861 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoacetylation strongly increases tubulin acetylation.|||Belongs to the acetyltransferase ATAT1 family.|||Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.|||Cytoplasm|||Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.|||axon|||clathrin-coated pit|||cytoskeleton|||focal adhesion|||spindle http://togogenome.org/gene/9685:SEC11A ^@ http://purl.uniprot.org/uniprot/A0A337S2H2|||http://purl.uniprot.org/uniprot/M3X3W0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:CDC45 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/9685:COPS6 ^@ http://purl.uniprot.org/uniprot/M3W0J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:GEM ^@ http://purl.uniprot.org/uniprot/A0A2I2UE29|||http://purl.uniprot.org/uniprot/M3WMR8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9685:URGCP ^@ http://purl.uniprot.org/uniprot/A0A5F5Y4E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9685:SLC6A13 ^@ http://purl.uniprot.org/uniprot/A0A5F5XLK7|||http://purl.uniprot.org/uniprot/M3WKI9 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9685:LDB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U675|||http://purl.uniprot.org/uniprot/M3WLS6 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9685:PIGS ^@ http://purl.uniprot.org/uniprot/M3W999 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:BIRC5 ^@ http://purl.uniprot.org/uniprot/Q6I6F4 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.|||Belongs to the IAP family.|||Chromosome|||Cytoplasm|||In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity. Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.|||Midbody|||Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8. Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce. Interacts with FBXL7; this interaction facilitates the polyubiquitination and subsequent proteasomal degradation of BIRC5 by the SCF(FBXL7) E3 ubiquitin-protein ligase complex (By similarity).|||Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity).|||Nucleus|||The BIR repeat is necessary and sufficient for LAMTOR5 binding.|||Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting. Deubiquitinated by USP35 or USP38; leading to stabilization.|||centromere|||kinetochore|||spindle http://togogenome.org/gene/9685:CAVIN1 ^@ http://purl.uniprot.org/uniprot/M3X6G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9685:AMIGO3 ^@ http://purl.uniprot.org/uniprot/M3WDP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9685:ID2 ^@ http://purl.uniprot.org/uniprot/M3X559 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:MRPS18C ^@ http://purl.uniprot.org/uniprot/A0A2I2V385 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/9685:SEC24C ^@ http://purl.uniprot.org/uniprot/M3WE89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9685:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZV8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:PRMT7 ^@ http://purl.uniprot.org/uniprot/A0A337S3M1|||http://purl.uniprot.org/uniprot/M3WJE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/9685:MYOZ1 ^@ http://purl.uniprot.org/uniprot/M3WJ62 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9685:FGD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4C3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:SLC17A1 ^@ http://purl.uniprot.org/uniprot/M3WL45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CEP57L1 ^@ http://purl.uniprot.org/uniprot/A0A337S6V5 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9685:PFKFB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYD2 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9685:AGO3 ^@ http://purl.uniprot.org/uniprot/M3WVQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/9685:MCM6 ^@ http://purl.uniprot.org/uniprot/M3WJ49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9685:LOC101092602 ^@ http://purl.uniprot.org/uniprot/M3XCT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. http://togogenome.org/gene/9685:FELCATV1R3 ^@ http://purl.uniprot.org/uniprot/M3X6N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101094372 ^@ http://purl.uniprot.org/uniprot/M3XE81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:UBE4B ^@ http://purl.uniprot.org/uniprot/M3WKZ0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9685:PRPF38A ^@ http://purl.uniprot.org/uniprot/M3VYN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/9685:ZKSCAN2 ^@ http://purl.uniprot.org/uniprot/M3WMA3 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9685:PRKCG ^@ http://purl.uniprot.org/uniprot/M3VWV6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane http://togogenome.org/gene/9685:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A5F5XH12|||http://purl.uniprot.org/uniprot/A0A5F5Y5M7|||http://purl.uniprot.org/uniprot/M3WZ76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:USP21 ^@ http://purl.uniprot.org/uniprot/M3WC74 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9685:LOC101083205 ^@ http://purl.uniprot.org/uniprot/M3WT72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ING3 ^@ http://purl.uniprot.org/uniprot/M3X266 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9685:ITGB4 ^@ http://purl.uniprot.org/uniprot/M3W4M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:C9 ^@ http://purl.uniprot.org/uniprot/M3WI95 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:SLC25A5 ^@ http://purl.uniprot.org/uniprot/M3VW78 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9685:LOC101083537 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CMAH ^@ http://purl.uniprot.org/uniprot/A0A143T1T8|||http://purl.uniprot.org/uniprot/A0A337SEU8|||http://purl.uniprot.org/uniprot/A0A5F5XEJ2|||http://purl.uniprot.org/uniprot/A0A5F5XQ06|||http://purl.uniprot.org/uniprot/A6Y8N2 ^@ Function|||Similarity ^@ Belongs to the CMP-Neu5Ac hydroxylase family.|||Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. http://togogenome.org/gene/9685:SMIM22 ^@ http://purl.uniprot.org/uniprot/A0A337S693 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GPRC5A ^@ http://purl.uniprot.org/uniprot/M3WJV7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:DDX49 ^@ http://purl.uniprot.org/uniprot/M3WC25 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9685:SH2B1 ^@ http://purl.uniprot.org/uniprot/A0A337RXI4|||http://purl.uniprot.org/uniprot/M3VZQ4 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9685:LOC101086628 ^@ http://purl.uniprot.org/uniprot/M3WR92 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9685:VPS33A ^@ http://purl.uniprot.org/uniprot/M3WQ76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9685:INHCA ^@ http://purl.uniprot.org/uniprot/M3X260 ^@ Similarity ^@ Belongs to the transferrin family. http://togogenome.org/gene/9685:LOC101092110 ^@ http://purl.uniprot.org/uniprot/M3X944 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DNAAF2 ^@ http://purl.uniprot.org/uniprot/M3XFH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PIH1 family. Kintoun subfamily.|||Cytoplasm|||Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.|||Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. http://togogenome.org/gene/9685:DVL1 ^@ http://purl.uniprot.org/uniprot/M3W823 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/9685:MSTN ^@ http://purl.uniprot.org/uniprot/M3WPT7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted http://togogenome.org/gene/9685:LANCL2 ^@ http://purl.uniprot.org/uniprot/M3X0R8 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9685:CYP11B1 ^@ http://purl.uniprot.org/uniprot/A0A337SVG1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9685:OS9 ^@ http://purl.uniprot.org/uniprot/A0A337S5G4|||http://purl.uniprot.org/uniprot/M3WL57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9685:SV2A ^@ http://purl.uniprot.org/uniprot/M3WCP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9685:DNAJC27 ^@ http://purl.uniprot.org/uniprot/A0A2I2USX2 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/9685:CASP12 ^@ http://purl.uniprot.org/uniprot/A9YEF1|||http://purl.uniprot.org/uniprot/M3W4Y8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9685:TOLLIP ^@ http://purl.uniprot.org/uniprot/M3VZP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tollip family.|||Cytoplasm http://togogenome.org/gene/9685:HIGD1B ^@ http://purl.uniprot.org/uniprot/M3W440 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9685:MRTO4 ^@ http://purl.uniprot.org/uniprot/M3WA75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9685:NAGK ^@ http://purl.uniprot.org/uniprot/M3WZW7 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/9685:RPL4 ^@ http://purl.uniprot.org/uniprot/M3WGN8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/9685:VPS26C ^@ http://purl.uniprot.org/uniprot/A0A2I2U0M6 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/9685:LOC101090867 ^@ http://purl.uniprot.org/uniprot/M3XBK8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9685:PDHB ^@ http://purl.uniprot.org/uniprot/M3VY34 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/9685:CPLX1 ^@ http://purl.uniprot.org/uniprot/A0A337SFH5|||http://purl.uniprot.org/uniprot/A0A5F5XKX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9685:CD4H9orf78 ^@ http://purl.uniprot.org/uniprot/M3W2T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/9685:KCNG4 ^@ http://purl.uniprot.org/uniprot/M3WFB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:MTM1 ^@ http://purl.uniprot.org/uniprot/M3X251 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9685:PON1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UU74 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9685:CDKL4 ^@ http://purl.uniprot.org/uniprot/M3X6A6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:NASP ^@ http://purl.uniprot.org/uniprot/A0A337S1D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/9685:MRPS31 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/9685:UMOD ^@ http://purl.uniprot.org/uniprot/M3W230 ^@ Caution|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||cilium membrane http://togogenome.org/gene/9685:EIF3G ^@ http://purl.uniprot.org/uniprot/M3WBC3 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.|||perinuclear region http://togogenome.org/gene/9685:ZNF687 ^@ http://purl.uniprot.org/uniprot/M3W4A3 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9685:PTK2B ^@ http://purl.uniprot.org/uniprot/A0A2I2ULP1|||http://purl.uniprot.org/uniprot/A0A2I2UXW4|||http://purl.uniprot.org/uniprot/A0A337ST84 ^@ Subcellular Location Annotation ^@ Cell membrane|||cell cortex|||focal adhesion http://togogenome.org/gene/9685:MDH1B ^@ http://purl.uniprot.org/uniprot/A0A5F5XM65 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/9685:LAPTM5 ^@ http://purl.uniprot.org/uniprot/M3XB38 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9685:HMCN1 ^@ http://purl.uniprot.org/uniprot/M3X1M2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:FIBIN ^@ http://purl.uniprot.org/uniprot/M3W7G7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers.|||Secreted http://togogenome.org/gene/9685:MIEF1 ^@ http://purl.uniprot.org/uniprot/M3WU06 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:FASLG ^@ http://purl.uniprot.org/uniprot/Q861W5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Homotrimer. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.|||Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.|||Lysosome lumen|||Monoubiquitinated.|||N-glycosylated. Glycosylation enhances apoptotic activity.|||Nucleus|||Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.|||Secreted|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells. http://togogenome.org/gene/9685:CHM ^@ http://purl.uniprot.org/uniprot/M3X8J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/9685:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A337SIJ7|||http://purl.uniprot.org/uniprot/M3WW94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9685:AKT1 ^@ http://purl.uniprot.org/uniprot/A0A143RHU3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9685:COQ5 ^@ http://purl.uniprot.org/uniprot/M3WEC1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/9685:NNT ^@ http://purl.uniprot.org/uniprot/M3W1L4 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9685:CHMP5 ^@ http://purl.uniprot.org/uniprot/M3X6F1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9685:HOXC8 ^@ http://purl.uniprot.org/uniprot/M3W2T7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TACR1 ^@ http://purl.uniprot.org/uniprot/M3W532 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9685:CYGB ^@ http://purl.uniprot.org/uniprot/M3W436 ^@ Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains. http://togogenome.org/gene/9685:DTX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZU2|||http://purl.uniprot.org/uniprot/M3WIX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9685:PTS ^@ http://purl.uniprot.org/uniprot/M3XBA1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PTPS family.|||Binds 1 zinc ion per subunit.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/9685:LOC102899190 ^@ http://purl.uniprot.org/uniprot/M3W2J1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LAMB2 ^@ http://purl.uniprot.org/uniprot/M3WC88 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9685:UROC1 ^@ http://purl.uniprot.org/uniprot/M3WN75 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/9685:ARPC3 ^@ http://purl.uniprot.org/uniprot/M3W1M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9685:MUSTN1 ^@ http://purl.uniprot.org/uniprot/A0A337S5P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MUSTANG family.|||Nucleus http://togogenome.org/gene/9685:GAR1 ^@ http://purl.uniprot.org/uniprot/A0A337S3V1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/9685:CISD2 ^@ http://purl.uniprot.org/uniprot/M3X8M2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CISD protein family. CISD2 subfamily.|||Binds 1 [2Fe-2S] cluster.|||Endoplasmic reticulum membrane|||Homodimer.|||Mitochondrion outer membrane|||Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. http://togogenome.org/gene/9685:LOC101100692 ^@ http://purl.uniprot.org/uniprot/M3WU09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CA5B ^@ http://purl.uniprot.org/uniprot/M3WVV0 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9685:CBLB ^@ http://purl.uniprot.org/uniprot/A0A337SBX7|||http://purl.uniprot.org/uniprot/M3W2E6 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9685:RABGGTA ^@ http://purl.uniprot.org/uniprot/M3W4C7 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. http://togogenome.org/gene/9685:CCND2 ^@ http://purl.uniprot.org/uniprot/M3VU57 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:MCOLN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5R1|||http://purl.uniprot.org/uniprot/M3WEM8 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9685:RNF167 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TAF5 ^@ http://purl.uniprot.org/uniprot/M3VYE8 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9685:SCAMP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9685:ARSJ ^@ http://purl.uniprot.org/uniprot/A0A2I2U9Q5 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9685:LOC101084707 ^@ http://purl.uniprot.org/uniprot/M3X726 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:PSMB8 ^@ http://purl.uniprot.org/uniprot/M3XF92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:ZPBP2 ^@ http://purl.uniprot.org/uniprot/M3X8S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted|||acrosome http://togogenome.org/gene/9685:NUP205 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2F9 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/9685:POP4 ^@ http://purl.uniprot.org/uniprot/M3VWZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Component of nuclear RNase P and RNase MRP.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9685:IRF1 ^@ http://purl.uniprot.org/uniprot/M3WIN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9685:CLASP1 ^@ http://purl.uniprot.org/uniprot/A0A337SQX3 ^@ Subcellular Location Annotation ^@ kinetochore http://togogenome.org/gene/9685:KRT84 ^@ http://purl.uniprot.org/uniprot/M3VUF7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:TPH2 ^@ http://purl.uniprot.org/uniprot/M3W5F9 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9685:NLGN1 ^@ http://purl.uniprot.org/uniprot/M3WA79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:NUF2 ^@ http://purl.uniprot.org/uniprot/M3W477 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9685:LOC102899212 ^@ http://purl.uniprot.org/uniprot/A0A5F5XPF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a ligand for KLRK1.|||Belongs to the NKG2D ligand family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:UBL4A ^@ http://purl.uniprot.org/uniprot/M3X745 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9685:DHTKD1 ^@ http://purl.uniprot.org/uniprot/M3WHR8 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9685:CLDN5 ^@ http://purl.uniprot.org/uniprot/M3WYM1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:DCTPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2J4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/9685:LOC101091397 ^@ http://purl.uniprot.org/uniprot/M3WEA8 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SMPD3 ^@ http://purl.uniprot.org/uniprot/M3XE75 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9685:SLC12A4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHF3|||http://purl.uniprot.org/uniprot/M3WHR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9685:MEPCE ^@ http://purl.uniprot.org/uniprot/M3WDY7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9685:RAB39A ^@ http://purl.uniprot.org/uniprot/A0A2I2UQL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A337SAU5 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9685:KPNA6 ^@ http://purl.uniprot.org/uniprot/A0A2I2V555 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9685:LOC101093429 ^@ http://purl.uniprot.org/uniprot/M3WQ30 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/9685:KEF43_p13 ^@ http://purl.uniprot.org/uniprot/P48900 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:POLR1C ^@ http://purl.uniprot.org/uniprot/M3WC04 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9685:HIGD2A ^@ http://purl.uniprot.org/uniprot/M3W7A4 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9685:PTPN6 ^@ http://purl.uniprot.org/uniprot/A0A337SE66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9685:CXCL16 ^@ http://purl.uniprot.org/uniprot/M3WSR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PSD4 ^@ http://purl.uniprot.org/uniprot/M3WBP9 ^@ Subcellular Location Annotation ^@ Membrane|||ruffle membrane http://togogenome.org/gene/9685:FGFR1 ^@ http://purl.uniprot.org/uniprot/H9U391 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Nucleus|||Vesicle|||cytosol http://togogenome.org/gene/9685:CCL21 ^@ http://purl.uniprot.org/uniprot/M3VZU3 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9685:PAN2 ^@ http://purl.uniprot.org/uniprot/M3WG70 ^@ Activity Regulation|||Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. PAN2 subfamily.|||Binds 2 metal cations per subunit in the catalytic exonuclease domain.|||Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.|||Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.|||Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||P-body|||Positively regulated by the regulatory subunit PAN3.|||The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3. http://togogenome.org/gene/9685:APOA4 ^@ http://purl.uniprot.org/uniprot/M3W955 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein A1/A4/E family.|||Homodimer.|||May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.|||Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.|||Secreted http://togogenome.org/gene/9685:LOC101086560 ^@ http://purl.uniprot.org/uniprot/M3WYS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:EDIL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3E6|||http://purl.uniprot.org/uniprot/M3VYL7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:PLET1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y3K4 ^@ Function ^@ Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. http://togogenome.org/gene/9685:SLC35C1 ^@ http://purl.uniprot.org/uniprot/M3WYQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ZUP1 ^@ http://purl.uniprot.org/uniprot/M3XGC8 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C78 family. ZUFSP subfamily.|||Interacts with RPA1 and RPA2. http://togogenome.org/gene/9685:FAP ^@ http://purl.uniprot.org/uniprot/M3X4T1 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9685:NTNG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U821|||http://purl.uniprot.org/uniprot/A0A2I2UY83|||http://purl.uniprot.org/uniprot/A0A337SSQ6|||http://purl.uniprot.org/uniprot/A0A5F5XLK0|||http://purl.uniprot.org/uniprot/M3VW60 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U704 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9685:CXXC1 ^@ http://purl.uniprot.org/uniprot/M3W5D0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PSIP1 ^@ http://purl.uniprot.org/uniprot/Q66T72 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ (Microbial infection) Interacts (via IBD domain) with feline immunodeficiency virus (FIV) integrase (IN), determining its nuclear localization, its tight association with chromatin and its protection from the proteasome.|||Belongs to the HDGF family.|||Citrullinated by PADI4.|||Monomer (By similarity). Interacts with IFRD1/PC4 (By similarity). Interacts (via IBD domain) with POGZ (via IBM motif) and CDCA7L (via IBM motifs) (By similarity). Interacts (via IBD domain) with KMT2A (via IBM motifs) with a moderate affinity whereas interacts with the KMT2A-MEN1 complex with a greater affinity; MEN1 enhances interaction of KMT2A with PSIP1 (By similarity). Interacts (via IBD domain) with IWS1 (via IBM motif), MED1 (via IBM motif) and DBF4 (via IBM motifs) (By similarity).|||Nucleus|||Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity). http://togogenome.org/gene/9685:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/M3W743 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:POSTN ^@ http://purl.uniprot.org/uniprot/A0A2I2U312|||http://purl.uniprot.org/uniprot/A0A2I2U6U3|||http://purl.uniprot.org/uniprot/A0A2I2UGA8|||http://purl.uniprot.org/uniprot/A0A2I2UGL9|||http://purl.uniprot.org/uniprot/A0A337RY02 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9685:BRPF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUY4|||http://purl.uniprot.org/uniprot/M3WK91 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CRYBA1 ^@ http://purl.uniprot.org/uniprot/M3WH19 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:IGBP1 ^@ http://purl.uniprot.org/uniprot/M3WY74 ^@ Similarity ^@ Belongs to the IGBP1/TAP42 family. http://togogenome.org/gene/9685:FCHO1 ^@ http://purl.uniprot.org/uniprot/M3W7U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FCHO family.|||clathrin-coated pit http://togogenome.org/gene/9685:GINS2 ^@ http://purl.uniprot.org/uniprot/M3W810 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/9685:CRYZ ^@ http://purl.uniprot.org/uniprot/M3XG55 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9685:CHCHD4 ^@ http://purl.uniprot.org/uniprot/A0A337SWR1 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9685:HOXA2 ^@ http://purl.uniprot.org/uniprot/M3W8N8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CCNG1 ^@ http://purl.uniprot.org/uniprot/M3WYN8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:CARTPT ^@ http://purl.uniprot.org/uniprot/M3VZP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/9685:ELL3 ^@ http://purl.uniprot.org/uniprot/M3W669 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9685:POLR3A ^@ http://purl.uniprot.org/uniprot/M3VVI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9685:ACVR2A ^@ http://purl.uniprot.org/uniprot/A0A2I2URP7|||http://purl.uniprot.org/uniprot/M3X9E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9685:FELCATV1R1 ^@ http://purl.uniprot.org/uniprot/M3WS89 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:ADRA2B ^@ http://purl.uniprot.org/uniprot/M3X1F7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.|||Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:ATP13A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGJ7|||http://purl.uniprot.org/uniprot/A0A2I2UUY0|||http://purl.uniprot.org/uniprot/M3WB80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/9685:SNX1 ^@ http://purl.uniprot.org/uniprot/M3W1Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium|||trans-Golgi network membrane http://togogenome.org/gene/9685:SLC22A1 ^@ http://purl.uniprot.org/uniprot/A0A337SUE7 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9685:DHX8 ^@ http://purl.uniprot.org/uniprot/M3WCC5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ELF4 ^@ http://purl.uniprot.org/uniprot/M3X1U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:CDC20 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ86 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9685:GASK1A ^@ http://purl.uniprot.org/uniprot/M3X5U4 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9685:SLC1A3 ^@ http://purl.uniprot.org/uniprot/M3W493 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9685:ME2 ^@ http://purl.uniprot.org/uniprot/M3W4G8 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9685:CPT2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XTI1|||http://purl.uniprot.org/uniprot/M3W4Z4 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9685:MGAT2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XW65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:TRIM9 ^@ http://purl.uniprot.org/uniprot/A0A2I2V2B5|||http://purl.uniprot.org/uniprot/M3VZ46 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:ERMAP ^@ http://purl.uniprot.org/uniprot/M3W0F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9685:NDUFS8 ^@ http://purl.uniprot.org/uniprot/M3VZI9 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/9685:GGNBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V1S6|||http://purl.uniprot.org/uniprot/M3W6Y8 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9685:LOC102901316 ^@ http://purl.uniprot.org/uniprot/A0A2I2UMU4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9685:NANOG ^@ http://purl.uniprot.org/uniprot/D3U663 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:AP1G1 ^@ http://purl.uniprot.org/uniprot/A0A337S743 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9685:LOC101081251 ^@ http://purl.uniprot.org/uniprot/M3X2X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GALE ^@ http://purl.uniprot.org/uniprot/M3WFT7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/9685:LOC101100002 ^@ http://purl.uniprot.org/uniprot/M3WRY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:HTR3E ^@ http://purl.uniprot.org/uniprot/M3W8D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9685:IL7 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Secreted http://togogenome.org/gene/9685:LOC101090225 ^@ http://purl.uniprot.org/uniprot/M3WN96 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9685:PPARD ^@ http://purl.uniprot.org/uniprot/A0A2I2U3X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9685:CENPH ^@ http://purl.uniprot.org/uniprot/A0A2I2V0F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9685:LIN7A ^@ http://purl.uniprot.org/uniprot/M3WLS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9685:ABCA9 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9T3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:SLC2A12 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y0G0 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. http://togogenome.org/gene/9685:CE2H16orf70 ^@ http://purl.uniprot.org/uniprot/M3WB35 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/9685:SEMA3E ^@ http://purl.uniprot.org/uniprot/M3WSU4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:RAB27B ^@ http://purl.uniprot.org/uniprot/A0A2I2UAX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9685:SGCG ^@ http://purl.uniprot.org/uniprot/A0A2I2U0C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9685:PPEF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5S1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9685:CETN1 ^@ http://purl.uniprot.org/uniprot/M3WB11 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9685:CEBPE ^@ http://purl.uniprot.org/uniprot/M3VYB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9685:LOC101087209 ^@ http://purl.uniprot.org/uniprot/M3WTX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101093772 ^@ http://purl.uniprot.org/uniprot/A0A337SW00 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:TEAD1 ^@ http://purl.uniprot.org/uniprot/A0A337RZ88|||http://purl.uniprot.org/uniprot/A0A337S195|||http://purl.uniprot.org/uniprot/A0A337S413|||http://purl.uniprot.org/uniprot/A0A337SMP7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101100940 ^@ http://purl.uniprot.org/uniprot/M3W153 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:KBTBD8 ^@ http://purl.uniprot.org/uniprot/M3WG05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/9685:SCGN ^@ http://purl.uniprot.org/uniprot/M3WL42 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/9685:MALL ^@ http://purl.uniprot.org/uniprot/A0A2I2UXL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:KEF43_p07 ^@ http://purl.uniprot.org/uniprot/P48892 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:CHRNG ^@ http://purl.uniprot.org/uniprot/A0A2I2UZR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:OXER1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6U4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:PTPN1 ^@ http://purl.uniprot.org/uniprot/M3W194 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9685:CHST3 ^@ http://purl.uniprot.org/uniprot/M3WI48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9685:PSMB1 ^@ http://purl.uniprot.org/uniprot/M3X6T9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:TOMM7 ^@ http://purl.uniprot.org/uniprot/A0A337S2F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:PEX19 ^@ http://purl.uniprot.org/uniprot/M3W181 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Membrane|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/9685:SAE1 ^@ http://purl.uniprot.org/uniprot/M3WUU9 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9685:ENPP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V568|||http://purl.uniprot.org/uniprot/M3WK44 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9685:PPP2R5E ^@ http://purl.uniprot.org/uniprot/M3WK80 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9685:ZDHHC17 ^@ http://purl.uniprot.org/uniprot/M3WZ05 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:PBX1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XTL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9685:NPFFR2 ^@ http://purl.uniprot.org/uniprot/M3WWS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9685:CORO2A ^@ http://purl.uniprot.org/uniprot/M3WS87 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9685:SLC28A3 ^@ http://purl.uniprot.org/uniprot/M3WDR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9685:CHMP7 ^@ http://purl.uniprot.org/uniprot/M3X7F4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9685:LOC101096719 ^@ http://purl.uniprot.org/uniprot/A0A337SPR9|||http://purl.uniprot.org/uniprot/A0A5F5XQ20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9685:LOC100302540 ^@ http://purl.uniprot.org/uniprot/C5NM73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:HOXA6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9685:TMCC2 ^@ http://purl.uniprot.org/uniprot/A0A337SB13 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9685:UPF3B ^@ http://purl.uniprot.org/uniprot/A0A2I2U4P2|||http://purl.uniprot.org/uniprot/M3W236 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9685:CCNA1 ^@ http://purl.uniprot.org/uniprot/M3W2K1 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9685:TNS1 ^@ http://purl.uniprot.org/uniprot/A0A337SMT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9685:LOC101091410 ^@ http://purl.uniprot.org/uniprot/A0A5F5XH42 ^@ Similarity ^@ Belongs to the SPATA31 family. http://togogenome.org/gene/9685:APLN ^@ http://purl.uniprot.org/uniprot/A0A337S4B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the apelin family.|||extracellular space http://togogenome.org/gene/9685:LOC101088734 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUB6 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9685:TEX10 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWT5 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/9685:SLC35A3 ^@ http://purl.uniprot.org/uniprot/M3X4D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:CD244 ^@ http://purl.uniprot.org/uniprot/M3W156 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:C7 ^@ http://purl.uniprot.org/uniprot/M3XAV7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:TRUB2 ^@ http://purl.uniprot.org/uniprot/M3W4S9 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9685:PTPN3 ^@ http://purl.uniprot.org/uniprot/M3WE86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9685:MTMR7 ^@ http://purl.uniprot.org/uniprot/M3WG34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9685:SNCA ^@ http://purl.uniprot.org/uniprot/A0A2I2U480 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synuclein family.|||Membrane|||Nucleus|||Secreted|||Synapse|||axon http://togogenome.org/gene/9685:CLDN11 ^@ http://purl.uniprot.org/uniprot/M3X7B3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:FOXB1 ^@ http://purl.uniprot.org/uniprot/M3XBW1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:GPC4 ^@ http://purl.uniprot.org/uniprot/M3W6M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9685:MED19 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3W1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/A0A337SM53 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:SPRING1 ^@ http://purl.uniprot.org/uniprot/M3VVT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:ATG9B ^@ http://purl.uniprot.org/uniprot/M3WIE1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9685:PDSS1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y0T5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9685:PEX2 ^@ http://purl.uniprot.org/uniprot/A0A337S911 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9685:PMM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UX50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9685:ALOX5AP ^@ http://purl.uniprot.org/uniprot/A0A2I2UDS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:RSBN1L ^@ http://purl.uniprot.org/uniprot/M3W1C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9685:TATDN2 ^@ http://purl.uniprot.org/uniprot/M3WEQ7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9685:TMEM255A ^@ http://purl.uniprot.org/uniprot/A0A337SRP5|||http://purl.uniprot.org/uniprot/M3WLM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/9685:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A2I2UVF7|||http://purl.uniprot.org/uniprot/A0A2I2V0K6|||http://purl.uniprot.org/uniprot/M3WS78 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9685:CUTC ^@ http://purl.uniprot.org/uniprot/M3X7S8 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/9685:BANF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101081158 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8E4|||http://purl.uniprot.org/uniprot/A0A5F5XSN2 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9685:WASL ^@ http://purl.uniprot.org/uniprot/A0A2I2U0M1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A337SQ77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9685:INO80D ^@ http://purl.uniprot.org/uniprot/M3X6W9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TPRG1L ^@ http://purl.uniprot.org/uniprot/M3WFF2 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9685:SEC61A1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:TPI1 ^@ http://purl.uniprot.org/uniprot/M3X9A1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/9685:MOGS ^@ http://purl.uniprot.org/uniprot/M3XE28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:CRYGN ^@ http://purl.uniprot.org/uniprot/M3WII0 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:DTNB ^@ http://purl.uniprot.org/uniprot/A0A2I2UNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9685:LOC101100942 ^@ http://purl.uniprot.org/uniprot/A0A5F5XE18|||http://purl.uniprot.org/uniprot/A0A5F5XW06|||http://purl.uniprot.org/uniprot/A0A5F5XXI4|||http://purl.uniprot.org/uniprot/A0A5F5Y3K8|||http://purl.uniprot.org/uniprot/M3XEE6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9685:TMCO3 ^@ http://purl.uniprot.org/uniprot/M3WKD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TUBB4B ^@ http://purl.uniprot.org/uniprot/M3W0Z9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9685:CAV2 ^@ http://purl.uniprot.org/uniprot/A0M8S6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).|||Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).|||Nucleus|||Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By. similarity).|||caveola http://togogenome.org/gene/9685:CCDC86 ^@ http://purl.uniprot.org/uniprot/M3WJ95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PHACTR1 ^@ http://purl.uniprot.org/uniprot/M3WKW8 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9685:CASTOR1 ^@ http://purl.uniprot.org/uniprot/M3WG12 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/9685:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/M3WC83 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9685:PARPBP ^@ http://purl.uniprot.org/uniprot/M3WMA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:DDX21 ^@ http://purl.uniprot.org/uniprot/A0A2I2V1N2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9685:HNF1B ^@ http://purl.uniprot.org/uniprot/A0A2I2UV93|||http://purl.uniprot.org/uniprot/M3VUC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9685:NCBP2 ^@ http://purl.uniprot.org/uniprot/M3XAX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/9685:SLC8A1 ^@ http://purl.uniprot.org/uniprot/P48767 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Activated by micromolar levels of Ca(2+).|||Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Detected in heart (at protein level). Detected in heart.|||Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.|||The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange. http://togogenome.org/gene/9685:GUCY2F ^@ http://purl.uniprot.org/uniprot/M3WAP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/9685:GTF2H3 ^@ http://purl.uniprot.org/uniprot/M3W0X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/9685:CCL8 ^@ http://purl.uniprot.org/uniprot/M3WJ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:NUBP1 ^@ http://purl.uniprot.org/uniprot/A0A337S3H3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/9685:GJC3 ^@ http://purl.uniprot.org/uniprot/M3XE26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:TSPAN5 ^@ http://purl.uniprot.org/uniprot/M3WK43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:LOC101092762 ^@ http://purl.uniprot.org/uniprot/M3WSM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:CENPC ^@ http://purl.uniprot.org/uniprot/M3X2X6 ^@ Similarity ^@ Belongs to the CENP-C/MIF2 family. http://togogenome.org/gene/9685:GRIA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7P0|||http://purl.uniprot.org/uniprot/A0A2I2UBD3|||http://purl.uniprot.org/uniprot/M3W9C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9685:MON2 ^@ http://purl.uniprot.org/uniprot/A0A337S7J0 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/9685:F7 ^@ http://purl.uniprot.org/uniprot/M3WKC6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:DYNLT3 ^@ http://purl.uniprot.org/uniprot/A0A337SD65 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9685:TRUB1 ^@ http://purl.uniprot.org/uniprot/M3WVR4 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9685:POLR1E ^@ http://purl.uniprot.org/uniprot/A0A337SNW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/9685:BROX ^@ http://purl.uniprot.org/uniprot/A0A5F5XRG8 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/9685:IGFBP5 ^@ http://purl.uniprot.org/uniprot/M3WQ08 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:PPFIBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3T0|||http://purl.uniprot.org/uniprot/A0A2I2UQB1 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9685:ELP6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBH8 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/9685:LOC101095034 ^@ http://purl.uniprot.org/uniprot/M3XG82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:STMN1 ^@ http://purl.uniprot.org/uniprot/M3WVG9 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9685:BMP4 ^@ http://purl.uniprot.org/uniprot/M3W2U0 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9685:LOC101096016 ^@ http://purl.uniprot.org/uniprot/M3WHJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:IL12A ^@ http://purl.uniprot.org/uniprot/O02743 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).|||Secreted http://togogenome.org/gene/9685:HOXB7 ^@ http://purl.uniprot.org/uniprot/M3VXX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9685:SERBP1 ^@ http://purl.uniprot.org/uniprot/M3VV33 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/9685:NCK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UF94 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9685:RNGTT ^@ http://purl.uniprot.org/uniprot/M3WWR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/9685:LOC101089671 ^@ http://purl.uniprot.org/uniprot/M3XDJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:THUMPD2 ^@ http://purl.uniprot.org/uniprot/M3W6J0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9685:LEP ^@ http://purl.uniprot.org/uniprot/Q9N2C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (By similarity). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (By similarity).|||Secreted http://togogenome.org/gene/9685:DLST ^@ http://purl.uniprot.org/uniprot/M3W5T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9685:USP16 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIC6|||http://purl.uniprot.org/uniprot/M3WJC9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homotetramer.|||Nucleus|||Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/9685:IFIH1 ^@ http://purl.uniprot.org/uniprot/A0A337SUY7|||http://purl.uniprot.org/uniprot/M3W7H1|||http://purl.uniprot.org/uniprot/M3WY86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9685:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/M3X977 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9685:GGT1 ^@ http://purl.uniprot.org/uniprot/M3VWS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/9685:DCP1B ^@ http://purl.uniprot.org/uniprot/M3W2X1 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9685:CHRM1 ^@ http://purl.uniprot.org/uniprot/M3VUK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9685:APOL6 ^@ http://purl.uniprot.org/uniprot/A0A337S9J7 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9685:CHCHD6 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:CD164 ^@ http://purl.uniprot.org/uniprot/A0A2I2UX23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9685:LOC101086441 ^@ http://purl.uniprot.org/uniprot/M3W9K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9685:NAPB ^@ http://purl.uniprot.org/uniprot/A0A337S7C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9685:LOC101087059 ^@ http://purl.uniprot.org/uniprot/A0A337SCV2|||http://purl.uniprot.org/uniprot/M3WWX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9685:LHX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4T1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:KCNK4 ^@ http://purl.uniprot.org/uniprot/M3WXT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9685:APOM ^@ http://purl.uniprot.org/uniprot/M3W828 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/9685:LOC101092789 ^@ http://purl.uniprot.org/uniprot/M3WTK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PARP9 ^@ http://purl.uniprot.org/uniprot/M3VV00 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9685:POLA1 ^@ http://purl.uniprot.org/uniprot/M3VXZ0 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/9685:GABPA ^@ http://purl.uniprot.org/uniprot/M3WWT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:IGF2BP2 ^@ http://purl.uniprot.org/uniprot/A0A337S262 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9685:STEAP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8U8|||http://purl.uniprot.org/uniprot/M3W731 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9685:FAM83G ^@ http://purl.uniprot.org/uniprot/M3WMK7 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9685:ARL8B ^@ http://purl.uniprot.org/uniprot/M3VVB1 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||spindle http://togogenome.org/gene/9685:NAA60 ^@ http://purl.uniprot.org/uniprot/A0A337S2H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/9685:FDXR ^@ http://purl.uniprot.org/uniprot/A0A337SC14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Mitochondrion|||Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. http://togogenome.org/gene/9685:TLR10 ^@ http://purl.uniprot.org/uniprot/M3W849 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9685:TMEM182 ^@ http://purl.uniprot.org/uniprot/M3X0N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SAP30L ^@ http://purl.uniprot.org/uniprot/A0A337S290 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/9685:NXF1 ^@ http://purl.uniprot.org/uniprot/M3WLB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/9685:PAPOLA ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ85 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9685:MYT1L ^@ http://purl.uniprot.org/uniprot/A0A337SDQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/9685:NEIL3 ^@ http://purl.uniprot.org/uniprot/M3W367 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/9685:LOC101101398 ^@ http://purl.uniprot.org/uniprot/M3WQN3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SBDS ^@ http://purl.uniprot.org/uniprot/M3X604 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/9685:MDM1 ^@ http://purl.uniprot.org/uniprot/A0A337SSU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM1 family.|||Nucleus|||centriole http://togogenome.org/gene/9685:MRPL50 ^@ http://purl.uniprot.org/uniprot/M3WTK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/9685:NAGPA ^@ http://purl.uniprot.org/uniprot/M3W2G0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:PSMD4 ^@ http://purl.uniprot.org/uniprot/A0A2I2V018 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/9685:CNIH1 ^@ http://purl.uniprot.org/uniprot/A0A337S421 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9685:BLM ^@ http://purl.uniprot.org/uniprot/M3W592 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/9685:RCAN3 ^@ http://purl.uniprot.org/uniprot/A0A337STC2|||http://purl.uniprot.org/uniprot/A0A5F5Y106 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9685:DCLRE1C ^@ http://purl.uniprot.org/uniprot/A0A2I2UH99|||http://purl.uniprot.org/uniprot/M3XCG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9685:PGF ^@ http://purl.uniprot.org/uniprot/A0A2I2UEE8|||http://purl.uniprot.org/uniprot/A0A337S6B9 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9685:LIPF ^@ http://purl.uniprot.org/uniprot/M3W796 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9685:IP6K1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3X1 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9685:SLC9A3R2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UT59 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:CYP7A1 ^@ http://purl.uniprot.org/uniprot/M3W8S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:SUPT5H ^@ http://purl.uniprot.org/uniprot/A0A337S2P9|||http://purl.uniprot.org/uniprot/M3WDU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/9685:LIG4 ^@ http://purl.uniprot.org/uniprot/M3XAQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9685:ARHGEF12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UB90|||http://purl.uniprot.org/uniprot/A0A5F5Y739|||http://purl.uniprot.org/uniprot/M3X136 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/9685:LOC101095601 ^@ http://purl.uniprot.org/uniprot/A0A2I2V413|||http://purl.uniprot.org/uniprot/A0A337SD14|||http://purl.uniprot.org/uniprot/A0A337SUD3|||http://purl.uniprot.org/uniprot/M3X254 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:BMI1 ^@ http://purl.uniprot.org/uniprot/Q9TST0 ^@ Function|||Induction|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Component of a PRC1-like complex. Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2. Interacts with RNF2/RING2 (By similarity). Interacts with RING1 (By similarity). Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. Interacts with CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. Interacts with PHC2 (By similarity). Interacts with zinc finger protein ZNF277 (By similarity). May be part of a complex including at least ZNF277, BMI1 and RNF2/RING2 (By similarity).|||Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.|||Cytoplasm|||Down-regulated by oxidative stress.|||May be polyubiquitinated; which does not lead to proteasomal degradation. Monoubiquitinated.|||Nucleus|||Transcripts are found in thymic lymphomas bearing insertions of the gene. Transcription is low or undetectable in mid-gestational fetal liver, neonatal and adult spleen, and in healthy lymph nodes. http://togogenome.org/gene/9685:PPP6R3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFD3|||http://purl.uniprot.org/uniprot/A0A337SIC0|||http://purl.uniprot.org/uniprot/M3W3F4|||http://purl.uniprot.org/uniprot/M3X6W7 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9685:DLL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXY8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:HMGCLL1 ^@ http://purl.uniprot.org/uniprot/M3W6I1 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/9685:GJC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U189 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/M3XCQ1 ^@ Subcellular Location Annotation ^@ Cytoplasmic granule http://togogenome.org/gene/9685:GNPAT ^@ http://purl.uniprot.org/uniprot/A0A2I2UWU0|||http://purl.uniprot.org/uniprot/A0A5F5XMU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/9685:LOC101088485 ^@ http://purl.uniprot.org/uniprot/M3X6T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:SPTBN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9P4 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9685:FAH ^@ http://purl.uniprot.org/uniprot/A0A5F5XI98|||http://purl.uniprot.org/uniprot/A0A5F5XYE6 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9685:KCNJ4 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y050 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9685:ALX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIK3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TIMM17B ^@ http://purl.uniprot.org/uniprot/M3VYR5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:PLK2 ^@ http://purl.uniprot.org/uniprot/M3WEE3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/9685:IFI35 ^@ http://purl.uniprot.org/uniprot/M3X4J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9685:MMACHC ^@ http://purl.uniprot.org/uniprot/M3VUA3 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/9685:PEX3 ^@ http://purl.uniprot.org/uniprot/M3XD19 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/9685:RBP4 ^@ http://purl.uniprot.org/uniprot/M5AXY1 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the calycin superfamily. Lipocalin family.|||Highly expressed in liver. Also expressed in adipose tissue (PubMed:23719693). Expressed by endometrium from days 16-25 and by unattached chorioallantois from days 30-36 during pregnancy (PubMed:2015342).|||Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.|||Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.|||Secreted|||Secreted in fetal fluids. Present on day 25, decreases from days 30-39, and disappears by day 50. Expressed by blastocysts on days 10-25 during prenatal development, but disappears by day 50. http://togogenome.org/gene/9685:CYP3A132 ^@ http://purl.uniprot.org/uniprot/A0A5F5XIP0|||http://purl.uniprot.org/uniprot/F8WKX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9685:PRDM1 ^@ http://purl.uniprot.org/uniprot/M3WDV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/9685:MRPL46 ^@ http://purl.uniprot.org/uniprot/M3WLP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/9685:LOC101094933 ^@ http://purl.uniprot.org/uniprot/M3XET7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ATP7B ^@ http://purl.uniprot.org/uniprot/A0A5F5XXB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9685:LOC101095924 ^@ http://purl.uniprot.org/uniprot/A0A337SEV0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9685:NFIB ^@ http://purl.uniprot.org/uniprot/A0A5F5XLX9|||http://purl.uniprot.org/uniprot/A0A5F5XMA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9685:TMX2 ^@ http://purl.uniprot.org/uniprot/M3WNB5 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9685:PALS1 ^@ http://purl.uniprot.org/uniprot/M3WEF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Endomembrane system|||adherens junction|||tight junction http://togogenome.org/gene/9685:QPCT ^@ http://purl.uniprot.org/uniprot/M3WST2 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/9685:STK4 ^@ http://purl.uniprot.org/uniprot/M3WYH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/9685:LOC101098159 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues. http://togogenome.org/gene/9685:P2RX1 ^@ http://purl.uniprot.org/uniprot/M3W8N3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9685:APOC1 ^@ http://purl.uniprot.org/uniprot/P0DM82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C1 family.|||Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.|||Secreted http://togogenome.org/gene/9685:HSF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9685:PDX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9685:BCL2L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAE3 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9685:TRPV1 ^@ http://purl.uniprot.org/uniprot/M3W8M4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CPXM1 ^@ http://purl.uniprot.org/uniprot/M3WKR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/9685:GJB5 ^@ http://purl.uniprot.org/uniprot/M3WJZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:LOC101090836 ^@ http://purl.uniprot.org/uniprot/A0A337S0A9 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9685:LONP2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XL09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.|||Belongs to the peptidase S16 family.|||Interacts with PEX5. Interacts with TYSND1.|||Peroxisome matrix http://togogenome.org/gene/9685:DPP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBQ8|||http://purl.uniprot.org/uniprot/A0A2I2UDP9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9685:ADGRG5 ^@ http://purl.uniprot.org/uniprot/A0A337S790 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:KCNA10 ^@ http://purl.uniprot.org/uniprot/M3X5X2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC493954 ^@ http://purl.uniprot.org/uniprot/O46524 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9685:PAX1 ^@ http://purl.uniprot.org/uniprot/M3W1Y0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TFR2 ^@ http://purl.uniprot.org/uniprot/M3W6L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:DERL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UMH5|||http://purl.uniprot.org/uniprot/A0A337S838 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9685:CCR3 ^@ http://purl.uniprot.org/uniprot/B6DXF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:DPPA5 ^@ http://purl.uniprot.org/uniprot/M3W6H1 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9685:LOC101087240 ^@ http://purl.uniprot.org/uniprot/M3WX42 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/9685:MED21 ^@ http://purl.uniprot.org/uniprot/A0A2I2UX14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9685:AGBL5 ^@ http://purl.uniprot.org/uniprot/A0A5F5XS39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Midbody|||Nucleus|||cytosol|||spindle http://togogenome.org/gene/9685:ZFX ^@ http://purl.uniprot.org/uniprot/M3WDG5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:DSC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZT4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9685:IFRD2 ^@ http://purl.uniprot.org/uniprot/M3W6X4 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9685:GPRASP2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XT20 ^@ Similarity ^@ Belongs to the GPRASP family. http://togogenome.org/gene/9685:ZDHHC16 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYH9|||http://purl.uniprot.org/uniprot/M3WIU3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:ESRRG ^@ http://purl.uniprot.org/uniprot/M3XCZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9685:CCNB2 ^@ http://purl.uniprot.org/uniprot/M3WBE0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:GNG12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXE2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9685:CCNC ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ30|||http://purl.uniprot.org/uniprot/M3W891 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:CALR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9685:SLC27A6 ^@ http://purl.uniprot.org/uniprot/M3WAX4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKP5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9685:CYSLTR2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y2B7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:PTGS1 ^@ http://purl.uniprot.org/uniprot/M3WEM6 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CD3D ^@ http://purl.uniprot.org/uniprot/A0A337SNX2|||http://purl.uniprot.org/uniprot/M3WFR0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:CYP21A2 ^@ http://purl.uniprot.org/uniprot/Q2LA60 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Microsome membrane|||Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.|||The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane. http://togogenome.org/gene/9685:LOC101091513 ^@ http://purl.uniprot.org/uniprot/M3WVZ1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NMNAT1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y742 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9685:SAMHD1 ^@ http://purl.uniprot.org/uniprot/M3WHZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAMHD1 family.|||Chromosome http://togogenome.org/gene/9685:CNPY2 ^@ http://purl.uniprot.org/uniprot/M3WG69 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9685:LOC101084720 ^@ http://purl.uniprot.org/uniprot/A0A5F5XEK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DAZAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4Y0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/9685:SERPINF1 ^@ http://purl.uniprot.org/uniprot/M3W5N1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:PDE7A ^@ http://purl.uniprot.org/uniprot/A0A2I2U050|||http://purl.uniprot.org/uniprot/M3VXT4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A337SJJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9685:PNMT ^@ http://purl.uniprot.org/uniprot/M3WCC0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9685:LOC101091307 ^@ http://purl.uniprot.org/uniprot/M3WVZ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues. http://togogenome.org/gene/9685:COX17 ^@ http://purl.uniprot.org/uniprot/M3W591 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9685:MTMR4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UU55|||http://purl.uniprot.org/uniprot/M3W297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9685:LOC101095681 ^@ http://purl.uniprot.org/uniprot/M3WGU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:IPMK ^@ http://purl.uniprot.org/uniprot/A0A337SC60|||http://purl.uniprot.org/uniprot/M3XDC4 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9685:CSF1R ^@ http://purl.uniprot.org/uniprot/P13369 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-558 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-558 and Tyr-807 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-696 and Tyr-921 is important for interaction with GRB2. Phosphorylation at Tyr-720 is important for interaction with PIK3R1. Phosphorylation at Tyr-720 and Tyr-807 is important for interaction with PLCG2. Phosphorylation at Tyr-977 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Monomer. Homodimer. Interacts with CSF1 and IL34. Interaction with dimeric CSF1 or IL34 leads to receptor homodimerization. Interacts with INPPL1/SHIP2 and THOC5. Interacts (tyrosine phosphorylated) with PLCG2 (via SH2 domain). Interacts (tyrosine phosphorylated) with PIK3R1 (via SH2 domain). Interacts (tyrosine phosphorylated) with FYN, YES1 and SRC (via SH2 domain). Interacts (tyrosine phosphorylated) with CBL, GRB2 and SLA2 (By similarity).|||Present in an inactive conformation in the absence of bound ligand. CSF1 or IL34 binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).|||The activation loop plays an important role in the regulation of kinase activity. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase (By similarity).|||The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase (By similarity).|||Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity). Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor (By similarity). In the central nervous system, may play a role in the development of microglia macrophages (By similarity).|||Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation (By similarity). http://togogenome.org/gene/9685:GDF5 ^@ http://purl.uniprot.org/uniprot/A0A2I2URW3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9685:CUX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U192 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASP family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:RPL18 ^@ http://purl.uniprot.org/uniprot/M3W9Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9685:NRN1L ^@ http://purl.uniprot.org/uniprot/M3X283 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9685:RPE65 ^@ http://purl.uniprot.org/uniprot/M3WH64 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9685:PENK ^@ http://purl.uniprot.org/uniprot/A0A2I2ULL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/9685:ATP6V1E2 ^@ http://purl.uniprot.org/uniprot/M3WFD4 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9685:ADGRL4 ^@ http://purl.uniprot.org/uniprot/A0A337SL34 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:SLC13A2 ^@ http://purl.uniprot.org/uniprot/M3W995 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9685:SELENOS ^@ http://purl.uniprot.org/uniprot/M3X9I4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein S family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.|||Membrane http://togogenome.org/gene/9685:CYSTM1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XS44 ^@ Similarity ^@ Belongs to the CYSTM1 family. http://togogenome.org/gene/9685:JMY ^@ http://purl.uniprot.org/uniprot/M3WTG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:B4GALT6 ^@ http://purl.uniprot.org/uniprot/M3WPN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9685:GPRC5B ^@ http://purl.uniprot.org/uniprot/A0A2I2UB41 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:VIL1 ^@ http://purl.uniprot.org/uniprot/M3VYE6 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9685:CSAD ^@ http://purl.uniprot.org/uniprot/A0A5F5XGY6 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/9685:LOC101081313 ^@ http://purl.uniprot.org/uniprot/M3W082 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LPCAT1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XF22 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9685:UTP25 ^@ http://purl.uniprot.org/uniprot/M3WM07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/9685:ECSIT ^@ http://purl.uniprot.org/uniprot/M3W343 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the ECSIT family.|||Cytoplasm|||Mitochondrion|||Nucleus http://togogenome.org/gene/9685:GK2 ^@ http://purl.uniprot.org/uniprot/A0A337SAZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9685:LIN7B ^@ http://purl.uniprot.org/uniprot/M3WP58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9685:ACAT2 ^@ http://purl.uniprot.org/uniprot/M3VZ88 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9685:GTPBP4 ^@ http://purl.uniprot.org/uniprot/M3XAH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9685:LOC101097234 ^@ http://purl.uniprot.org/uniprot/M3XDF4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:AXIN2 ^@ http://purl.uniprot.org/uniprot/M3XAL0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:PPP1R9B ^@ http://purl.uniprot.org/uniprot/M3WXL9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/9685:MTMR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3B3|||http://purl.uniprot.org/uniprot/A0A2I2ULX1|||http://purl.uniprot.org/uniprot/A0A2I2V1C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9685:IFNE ^@ http://purl.uniprot.org/uniprot/I3UJJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9685:DUSP16 ^@ http://purl.uniprot.org/uniprot/M3WZQ1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9685:RAB39B ^@ http://purl.uniprot.org/uniprot/A0A2I2UDI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:FGF16 ^@ http://purl.uniprot.org/uniprot/M3WSS3 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9685:SAP30 ^@ http://purl.uniprot.org/uniprot/M3WR27 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/9685:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/M3WXP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:COA7 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/9685:CPNE8 ^@ http://purl.uniprot.org/uniprot/M3XCA2 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9685:GMDS ^@ http://purl.uniprot.org/uniprot/M3W2U5 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/9685:SSBP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2URT0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101081743 ^@ http://purl.uniprot.org/uniprot/M3WUN4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9685:SERP1 ^@ http://purl.uniprot.org/uniprot/M3WEX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/9685:CXCR5 ^@ http://purl.uniprot.org/uniprot/M3XAS4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:PLP1 ^@ http://purl.uniprot.org/uniprot/M3X0A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9685:XPR1 ^@ http://purl.uniprot.org/uniprot/E2J866|||http://purl.uniprot.org/uniprot/M3WFX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/9685:TAF11 ^@ http://purl.uniprot.org/uniprot/A0A2I2URS1|||http://purl.uniprot.org/uniprot/M3WTA9 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/9685:OPN1LW ^@ http://purl.uniprot.org/uniprot/O18913 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.|||The three color pigments are found in the cone photoreceptor cells. Expressed in retina (PubMed:10511567).|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. http://togogenome.org/gene/9685:GIMAP6 ^@ http://purl.uniprot.org/uniprot/A0A337S2L7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9685:LOC101088358 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y4J9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SUMF2 ^@ http://purl.uniprot.org/uniprot/M3VZI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9685:LETM1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y4I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LETM1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:TVP23A ^@ http://purl.uniprot.org/uniprot/M3WCB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9685:TECPR1 ^@ http://purl.uniprot.org/uniprot/M3VUI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TECPR1 family.|||Lysosome membrane|||autophagosome membrane http://togogenome.org/gene/9685:FFAR1 ^@ http://purl.uniprot.org/uniprot/M3X1M3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:KCNJ5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UE47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.|||Membrane http://togogenome.org/gene/9685:STEAP4 ^@ http://purl.uniprot.org/uniprot/M3XEC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9685:BRINP3 ^@ http://purl.uniprot.org/uniprot/M3XDI2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9685:LOC101099760 ^@ http://purl.uniprot.org/uniprot/M3X6S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:CPLX3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XQN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9685:ASAH1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0N3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/9685:UFC1 ^@ http://purl.uniprot.org/uniprot/M3WC73 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.|||E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9685:EFHC1 ^@ http://purl.uniprot.org/uniprot/M3WF69 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9685:CCNJL ^@ http://purl.uniprot.org/uniprot/M3XA43 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:DYNLT1 ^@ http://purl.uniprot.org/uniprot/M3W8R7 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9685:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWX9|||http://purl.uniprot.org/uniprot/A0A337SVA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9685:OAZ2 ^@ http://purl.uniprot.org/uniprot/M3WEX4 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9685:SLC50A1 ^@ http://purl.uniprot.org/uniprot/M3XFN7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates sugar transport across membranes.|||Membrane http://togogenome.org/gene/9685:LOC101081667 ^@ http://purl.uniprot.org/uniprot/M3WQY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DLC1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XMR8|||http://purl.uniprot.org/uniprot/A0A5F5XRG1|||http://purl.uniprot.org/uniprot/A0A5F5Y519 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:XKRX ^@ http://purl.uniprot.org/uniprot/M3W6W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9685:TOMM40L ^@ http://purl.uniprot.org/uniprot/A0A2I2ULV8|||http://purl.uniprot.org/uniprot/M3WN88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:ZNF768 ^@ http://purl.uniprot.org/uniprot/M3WC53 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:DDX50 ^@ http://purl.uniprot.org/uniprot/M3XBG7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9685:ACTR10 ^@ http://purl.uniprot.org/uniprot/M3WSZ8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:RUNDC3A ^@ http://purl.uniprot.org/uniprot/A0A337SJB9|||http://purl.uniprot.org/uniprot/M3VZM5 ^@ Similarity ^@ Belongs to the RUNDC3 family. http://togogenome.org/gene/9685:XIRP2 ^@ http://purl.uniprot.org/uniprot/A0A337SLV6 ^@ Domain|||Function|||Similarity ^@ Belongs to the Xin family.|||Protects actin filaments from depolymerization.|||Xin repeats bind F-actin. http://togogenome.org/gene/9685:C8G ^@ http://purl.uniprot.org/uniprot/M3VUN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9685:POU4F3 ^@ http://purl.uniprot.org/uniprot/M3WWX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9685:ACTR8 ^@ http://purl.uniprot.org/uniprot/M3WI28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/9685:TRPC5 ^@ http://purl.uniprot.org/uniprot/M3WDM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101093951 ^@ http://purl.uniprot.org/uniprot/M3XC39 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9685:PSMB4 ^@ http://purl.uniprot.org/uniprot/M3VXE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9685:RNPC3 ^@ http://purl.uniprot.org/uniprot/M3X571 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.|||Nucleus|||Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. http://togogenome.org/gene/9685:HMGCL ^@ http://purl.uniprot.org/uniprot/M3WFT8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/9685:SLC25A17 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYF3|||http://purl.uniprot.org/uniprot/M3WMM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:MEIS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UH05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9685:UGT1A1 ^@ http://purl.uniprot.org/uniprot/M3WBX4|||http://purl.uniprot.org/uniprot/O46548 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9685:EIF4EBP1 ^@ http://purl.uniprot.org/uniprot/M3WD87 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9685:VPS53 ^@ http://purl.uniprot.org/uniprot/M3VX26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9685:IL4 ^@ http://purl.uniprot.org/uniprot/A0A337RWU7|||http://purl.uniprot.org/uniprot/P55030 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-4/IL-13 family.|||Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.|||Secreted http://togogenome.org/gene/9685:TMEM234 ^@ http://purl.uniprot.org/uniprot/M3XA96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/9685:KRT18 ^@ http://purl.uniprot.org/uniprot/M3VUH3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:CDSN ^@ http://purl.uniprot.org/uniprot/M3X143 ^@ Function|||Subcellular Location Annotation ^@ Important for the epidermal barrier integrity.|||Secreted http://togogenome.org/gene/9685:QRFPR ^@ http://purl.uniprot.org/uniprot/M3WYK8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:RAD23A ^@ http://purl.uniprot.org/uniprot/M3X1H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9685:ENTPD8 ^@ http://purl.uniprot.org/uniprot/M3W0L3 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9685:DSCC1 ^@ http://purl.uniprot.org/uniprot/M3WE83 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/9685:HOXC9 ^@ http://purl.uniprot.org/uniprot/M3WTV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9685:KCNC1 ^@ http://purl.uniprot.org/uniprot/M3W381 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GRHPR ^@ http://purl.uniprot.org/uniprot/A0A5F5XTU8|||http://purl.uniprot.org/uniprot/M3WI68 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/9685:HIBADH ^@ http://purl.uniprot.org/uniprot/M3X8B5 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/9685:BLCAP ^@ http://purl.uniprot.org/uniprot/P62953 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLCAP family.|||May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and nuclear factor kappa B (NF-kappaB).|||Membrane http://togogenome.org/gene/9685:LOC101089822 ^@ http://purl.uniprot.org/uniprot/A0A1K0FUL4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues. http://togogenome.org/gene/9685:HGF ^@ http://purl.uniprot.org/uniprot/Q9BH09 ^@ Caution|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity (By similarity).|||Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.|||Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (By similarity). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). Activates MAPK signaling following TMPRSS13 cleavage and activation (By similarity).|||The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form. http://togogenome.org/gene/9685:NCF2 ^@ http://purl.uniprot.org/uniprot/M3X0B4 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9685:TNNT2 ^@ http://purl.uniprot.org/uniprot/A0A337SQ49|||http://purl.uniprot.org/uniprot/Q8HYJ0 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9685:RARB ^@ http://purl.uniprot.org/uniprot/M3WD77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9685:LOC101097721 ^@ http://purl.uniprot.org/uniprot/A0A337SKR4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:EPHA4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UV62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TEF ^@ http://purl.uniprot.org/uniprot/A0A2I2UA43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9685:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKP0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:CACUL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFD8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9685:CD82 ^@ http://purl.uniprot.org/uniprot/M3WHR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:IFNW12 ^@ http://purl.uniprot.org/uniprot/Q0GYU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9685:BACE1 ^@ http://purl.uniprot.org/uniprot/M3VU83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/9685:CS ^@ http://purl.uniprot.org/uniprot/M3WG68 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/9685:CCNO ^@ http://purl.uniprot.org/uniprot/M3XG04 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:MRPL15 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNR9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9685:RPS11 ^@ http://purl.uniprot.org/uniprot/M3WAZ1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9685:USP5 ^@ http://purl.uniprot.org/uniprot/M3W1X0 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9685:ELOF1 ^@ http://purl.uniprot.org/uniprot/M3W344 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/9685:PIH1D1 ^@ http://purl.uniprot.org/uniprot/M3WAY6 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9685:SMARCA5 ^@ http://purl.uniprot.org/uniprot/M3W2D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9685:MUTYH ^@ http://purl.uniprot.org/uniprot/A0A5F5Y3T9 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs.|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9685:ESRRA ^@ http://purl.uniprot.org/uniprot/A0A2I2U440 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9685:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9685:AMY2B ^@ http://purl.uniprot.org/uniprot/M3X5H0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9685:LOC101091336 ^@ http://purl.uniprot.org/uniprot/M3WKD2 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9685:RPN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UR06|||http://purl.uniprot.org/uniprot/A0A337SS26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9685:PYM1 ^@ http://purl.uniprot.org/uniprot/M3WJU1 ^@ Similarity|||Subunit ^@ Belongs to the pym family.|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/9685:REXO2 ^@ http://purl.uniprot.org/uniprot/M3WPD6 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/9685:MTERF3 ^@ http://purl.uniprot.org/uniprot/M3WQZ6 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9685:IKBKB ^@ http://purl.uniprot.org/uniprot/A0A337S8J3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:NAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A337SCC2|||http://purl.uniprot.org/uniprot/A0A337SMA3|||http://purl.uniprot.org/uniprot/M3VUF4 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9685:HSPD1 ^@ http://purl.uniprot.org/uniprot/M3WXZ4 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/9685:CA3H20orf27 ^@ http://purl.uniprot.org/uniprot/M3X3E2 ^@ Similarity ^@ Belongs to the ADISSP family. http://togogenome.org/gene/9685:TFRC ^@ http://purl.uniprot.org/uniprot/A0A2I2UIM1|||http://purl.uniprot.org/uniprot/Q9MYZ3 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4 (By similarity). Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).|||Melanosome|||Membrane|||N- and O-glycosylated, phosphorylated and palmitoylated.|||Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity).|||Stearoylated.|||The YTRF endocytosis motif engages the clathrin-mediated endocytic machinery through adapter protein-2. http://togogenome.org/gene/9685:CFAP36 ^@ http://purl.uniprot.org/uniprot/M3W0H8 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/9685:ELP3 ^@ http://purl.uniprot.org/uniprot/M3X6K4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/9685:CPNE4 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0Z9 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9685:HEXA ^@ http://purl.uniprot.org/uniprot/G4XSV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9685:CDKN2AIP ^@ http://purl.uniprot.org/uniprot/M3WU69 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9685:SLC7A6 ^@ http://purl.uniprot.org/uniprot/M3WJE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101091569 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9685:TXLNB ^@ http://purl.uniprot.org/uniprot/M3WN09 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9685:DARS1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y2Y4|||http://purl.uniprot.org/uniprot/M3WKG0 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9685:LOC101084607 ^@ http://purl.uniprot.org/uniprot/M3X2Q0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LIN54 ^@ http://purl.uniprot.org/uniprot/M3WPK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9685:WNK4 ^@ http://purl.uniprot.org/uniprot/M3X4Y8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9685:RPL17 ^@ http://purl.uniprot.org/uniprot/Q5XTY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9685:OST4 ^@ http://purl.uniprot.org/uniprot/A0A337S2V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:EDC3 ^@ http://purl.uniprot.org/uniprot/A0A337SM77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/9685:CDH20 ^@ http://purl.uniprot.org/uniprot/M3VZV0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101095768 ^@ http://purl.uniprot.org/uniprot/M3X512 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SCGB1A1 ^@ http://purl.uniprot.org/uniprot/M3WAC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9685:LOC101099185 ^@ http://purl.uniprot.org/uniprot/A0A337S974 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PRL ^@ http://purl.uniprot.org/uniprot/P46403 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the somatotropin/prolactin family.|||Interacts with PRLR.|||Prolactin acts primarily on the mammary gland by promoting lactation.|||Secreted http://togogenome.org/gene/9685:CCN6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNS1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:A1CF ^@ http://purl.uniprot.org/uniprot/M3WEL9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:PC ^@ http://purl.uniprot.org/uniprot/A0A2I2UTX2|||http://purl.uniprot.org/uniprot/M3W7N8 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/9685:SGTB ^@ http://purl.uniprot.org/uniprot/M3VYH7 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9685:SH3BP5 ^@ http://purl.uniprot.org/uniprot/M3WIF7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9685:ING4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U6Q5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9685:COPG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9685:LOC101099822 ^@ http://purl.uniprot.org/uniprot/M3X544 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/9685:ANKH ^@ http://purl.uniprot.org/uniprot/M3WGL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/9685:NEU3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWF4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9685:ODF2 ^@ http://purl.uniprot.org/uniprot/A0A337S5F5|||http://purl.uniprot.org/uniprot/M3W4T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9685:TFAP2B ^@ http://purl.uniprot.org/uniprot/A0A2I2U397|||http://purl.uniprot.org/uniprot/A0A2I2UT09|||http://purl.uniprot.org/uniprot/M3WMP4 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9685:B2M ^@ http://purl.uniprot.org/uniprot/Q5MGS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-2-microglobulin family.|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).|||Secreted http://togogenome.org/gene/9685:DSEL ^@ http://purl.uniprot.org/uniprot/A0A5F5Y3C0 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9685:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/9685:STAM2 ^@ http://purl.uniprot.org/uniprot/M3WQ89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9685:TLCD3A ^@ http://purl.uniprot.org/uniprot/A0A337RZ74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ALG10 ^@ http://purl.uniprot.org/uniprot/M3XFR9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:MFGE8 ^@ http://purl.uniprot.org/uniprot/A0A5F5XE10|||http://purl.uniprot.org/uniprot/M3W678 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SLC14A2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XWY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:NUMB ^@ http://purl.uniprot.org/uniprot/A0A2I2UNE8|||http://purl.uniprot.org/uniprot/A0A337STB3|||http://purl.uniprot.org/uniprot/M3X6J0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9685:OXSM ^@ http://purl.uniprot.org/uniprot/M3WHK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.|||Mitochondrion http://togogenome.org/gene/9685:OLFM4 ^@ http://purl.uniprot.org/uniprot/M3WZE7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:HOXA9 ^@ http://purl.uniprot.org/uniprot/A0A337SVI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9685:LOC101095575 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0H2 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9685:HS3ST6 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3N3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9685:TUBB ^@ http://purl.uniprot.org/uniprot/M3X7Z9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9685:SLC25A45 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:POLR3K ^@ http://purl.uniprot.org/uniprot/A0A2I2U4L4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9685:MRGPRX2 ^@ http://purl.uniprot.org/uniprot/M3XBY5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:CARMIL3 ^@ http://purl.uniprot.org/uniprot/A0A337S417 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9685:MLST8 ^@ http://purl.uniprot.org/uniprot/M3XDU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.|||Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA. http://togogenome.org/gene/9685:PFKFB4 ^@ http://purl.uniprot.org/uniprot/A0A5F5XDE7|||http://purl.uniprot.org/uniprot/A0A5F5XJL2|||http://purl.uniprot.org/uniprot/A0A5F5Y461|||http://purl.uniprot.org/uniprot/M3VXW4 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9685:FARS2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XK13|||http://purl.uniprot.org/uniprot/A0A5F5XSG3|||http://purl.uniprot.org/uniprot/M3XBZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/9685:HIRA ^@ http://purl.uniprot.org/uniprot/A0A5F5XXS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/9685:SMPX ^@ http://purl.uniprot.org/uniprot/A0A337RWK0 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/9685:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/A0A337S4B0|||http://purl.uniprot.org/uniprot/A0A337SUH8 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9685:ATP5PD ^@ http://purl.uniprot.org/uniprot/M3XC82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:HDHD2 ^@ http://purl.uniprot.org/uniprot/M3VZ53 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9685:PDE10A ^@ http://purl.uniprot.org/uniprot/A0A337SUW8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:XDH ^@ http://purl.uniprot.org/uniprot/Q9MYW6 ^@ Activity Regulation|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters per subunit.|||Can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.|||Contains sulfhydryl groups that are easily oxidized (in vitro); this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O).|||Cytoplasm|||Homodimer. Interacts with BTN1A1 (By similarity).|||Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.|||Peroxisome|||Secreted|||Subject to partial proteolysis; this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O). http://togogenome.org/gene/9685:LOC101087005 ^@ http://purl.uniprot.org/uniprot/A0A2I2U891 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101093987 ^@ http://purl.uniprot.org/uniprot/M3WUE8 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ADK ^@ http://purl.uniprot.org/uniprot/A0A337SQ33 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/9685:CANX ^@ http://purl.uniprot.org/uniprot/M3XBV5 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9685:PRPH2 ^@ http://purl.uniprot.org/uniprot/P35906 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the PRPH2/ROM1 family.|||Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity).|||Homodimer; disulfide-linked (By similarity). Forms a homotetramer (By similarity). Forms a heterotetramer with ROM1 (By similarity). Homotetramer and heterotetramer core complexes go on to form higher order complexes by formation of intermolecular disulfide bonds (By similarity). Interacts with MREG (By similarity). Interacts with STX3 (By similarity). Interacts with SNAP25 (By similarity).|||Membrane|||Photoreceptor inner segment|||Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.|||photoreceptor outer segment http://togogenome.org/gene/9685:ADAMTS9 ^@ http://purl.uniprot.org/uniprot/A0A337S637|||http://purl.uniprot.org/uniprot/M3VWV5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9685:MYOD1 ^@ http://purl.uniprot.org/uniprot/M3W380 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9685:TPX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UW03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/9685:B3GAT2 ^@ http://purl.uniprot.org/uniprot/A0A337SNA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:FAM241B ^@ http://purl.uniprot.org/uniprot/M3WRB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9685:HADHA ^@ http://purl.uniprot.org/uniprot/M3WLM2 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9685:ORC5 ^@ http://purl.uniprot.org/uniprot/M3WTS9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4C2|||http://purl.uniprot.org/uniprot/M3VZ51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:LAMP2 ^@ http://purl.uniprot.org/uniprot/M3X6R8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9685:CLTA ^@ http://purl.uniprot.org/uniprot/A0A2I2UG69|||http://purl.uniprot.org/uniprot/A0A2I2V3L5|||http://purl.uniprot.org/uniprot/A0A5F5XT91|||http://purl.uniprot.org/uniprot/A0A5F5XUC1|||http://purl.uniprot.org/uniprot/M3WHJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9685:ADGRB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4L1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:POLR2C ^@ http://purl.uniprot.org/uniprot/A0A2I2UWP3 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9685:KCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2USQ4|||http://purl.uniprot.org/uniprot/A0A2I2V2Y1|||http://purl.uniprot.org/uniprot/M3X8N9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:XRCC1 ^@ http://purl.uniprot.org/uniprot/M3W3P2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:RAB14 ^@ http://purl.uniprot.org/uniprot/M3WTD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/9685:TVP23B ^@ http://purl.uniprot.org/uniprot/M3WRF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9685:MED28 ^@ http://purl.uniprot.org/uniprot/M3WXV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 28 family.|||Nucleus http://togogenome.org/gene/9685:GDPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXR5 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9685:RAB9B ^@ http://purl.uniprot.org/uniprot/M3VUR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9685:MRAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:GJA1 ^@ http://purl.uniprot.org/uniprot/M3X8Y2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Endoplasmic reticulum|||Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:DLD ^@ http://purl.uniprot.org/uniprot/M3W291 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||acrosome|||flagellum http://togogenome.org/gene/9685:ANKRD13C ^@ http://purl.uniprot.org/uniprot/A0A2I2V5F3|||http://purl.uniprot.org/uniprot/A0A5F5Y301 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GJA9 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7D2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:S100A16 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4Z5 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9685:GJA8 ^@ http://purl.uniprot.org/uniprot/A0A5F5XUZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:SF3B6 ^@ http://purl.uniprot.org/uniprot/M3X5D4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A2I2U384 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9685:RUNDC3B ^@ http://purl.uniprot.org/uniprot/A0A2I2UAH5|||http://purl.uniprot.org/uniprot/A0A2I2UYT1|||http://purl.uniprot.org/uniprot/M3WTS7 ^@ Similarity|||Subunit ^@ Belongs to the RUNDC3 family.|||Interacts with RAP2A. http://togogenome.org/gene/9685:SMU1 ^@ http://purl.uniprot.org/uniprot/M3WA50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9685:PTHLH ^@ http://purl.uniprot.org/uniprot/M3W9D7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Cytoplasm|||Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.|||Nucleus|||Osteostatin is a potent inhibitor of osteoclastic bone resorption.|||PTHrP interacts with PTH1R (via N-terminal extracellular domain).|||Secreted|||There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. http://togogenome.org/gene/9685:ACKR3 ^@ http://purl.uniprot.org/uniprot/M3WH59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UA14 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:SCNM1 ^@ http://purl.uniprot.org/uniprot/M3W498 ^@ Subcellular Location Annotation ^@ Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9685:TUBGCP3 ^@ http://purl.uniprot.org/uniprot/M3W0Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9685:CTBP2 ^@ http://purl.uniprot.org/uniprot/M3VYH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9685:SYNCRIP ^@ http://purl.uniprot.org/uniprot/M3WUF3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:LOC101089384 ^@ http://purl.uniprot.org/uniprot/A0A5F5XXQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ELL2 ^@ http://purl.uniprot.org/uniprot/M3XFW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9685:RALY ^@ http://purl.uniprot.org/uniprot/A0A2I2U159 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9685:KRT222 ^@ http://purl.uniprot.org/uniprot/M3WNT7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:RNF5 ^@ http://purl.uniprot.org/uniprot/M3W2C7 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9685:UFM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2USD4 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/9685:NCAPD3 ^@ http://purl.uniprot.org/uniprot/A0A337S6P0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the condensin-2 complex.|||Nucleus|||Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. http://togogenome.org/gene/9685:CISD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVA0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CISD protein family. CISD2 subfamily.|||Binds 1 [2Fe-2S] cluster.|||Endoplasmic reticulum membrane|||Homodimer.|||Mitochondrion outer membrane|||Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. http://togogenome.org/gene/9685:GOT2 ^@ http://purl.uniprot.org/uniprot/M3XE42 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9685:B9D1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXA5 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9685:MRPL19 ^@ http://purl.uniprot.org/uniprot/M3WYB9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/9685:GAL3ST3 ^@ http://purl.uniprot.org/uniprot/M3WIL0 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9685:CCS ^@ http://purl.uniprot.org/uniprot/A0A2I2UBN3 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/9685:KRT74 ^@ http://purl.uniprot.org/uniprot/A0A5K1UI54 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:PANX3 ^@ http://purl.uniprot.org/uniprot/M3VYU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9685:PFN4 ^@ http://purl.uniprot.org/uniprot/M3W1Z0 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9685:DDX55 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8R4 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9685:TAAR1 ^@ http://purl.uniprot.org/uniprot/M3XEU0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:COX7A1 ^@ http://purl.uniprot.org/uniprot/M3WK61 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9685:SMPD2 ^@ http://purl.uniprot.org/uniprot/M3W5S2 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9685:MTIF3 ^@ http://purl.uniprot.org/uniprot/M3W6V3 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/9685:RNASE13 ^@ http://purl.uniprot.org/uniprot/M3X3R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9685:NCOA3 ^@ http://purl.uniprot.org/uniprot/M3WLT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9685:CCL17 ^@ http://purl.uniprot.org/uniprot/Q8I021 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the intercrine beta (chemokine CC) family.|||Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation (By similarity). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity).|||Expressed in thymus and also in spleen, lung, lymph node, kidney, small intestine, colon and skin.|||Secreted http://togogenome.org/gene/9685:CAPN6 ^@ http://purl.uniprot.org/uniprot/M3WF83 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:TUBD1 ^@ http://purl.uniprot.org/uniprot/M3W0Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9685:HK2 ^@ http://purl.uniprot.org/uniprot/M3W529 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9685:MBOAT4 ^@ http://purl.uniprot.org/uniprot/M3X7K6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:KCND1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XJP8|||http://purl.uniprot.org/uniprot/M3VYS3 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/9685:CLK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHV8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:HSPA4 ^@ http://purl.uniprot.org/uniprot/M3WGX4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/9685:SEPTIN12 ^@ http://purl.uniprot.org/uniprot/M3X7A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9685:RPL37A ^@ http://purl.uniprot.org/uniprot/A0A2I2UCL4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9685:NR1D1 ^@ http://purl.uniprot.org/uniprot/M3WLR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9685:AMELX ^@ http://purl.uniprot.org/uniprot/M3X6K3 ^@ Similarity ^@ Belongs to the amelogenin family. http://togogenome.org/gene/9685:SNX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUC7|||http://purl.uniprot.org/uniprot/M3WP68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/9685:QTRT2 ^@ http://purl.uniprot.org/uniprot/M3XBM2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/9685:P2RY4 ^@ http://purl.uniprot.org/uniprot/M3W927 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:TCP1 ^@ http://purl.uniprot.org/uniprot/M3VZ89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||centrosome http://togogenome.org/gene/9685:TMEM230 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEA0|||http://purl.uniprot.org/uniprot/A0A5F5XLT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9685:USP1 ^@ http://purl.uniprot.org/uniprot/M3X7I7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9685:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A2I2U8I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9685:LOC102899273 ^@ http://purl.uniprot.org/uniprot/A0A5F5XR40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:PSMB10 ^@ http://purl.uniprot.org/uniprot/M3WHR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:PPIL3 ^@ http://purl.uniprot.org/uniprot/M3W3Y9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9685:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/9685:TNFRSF4 ^@ http://purl.uniprot.org/uniprot/Q75SV8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:RAB29 ^@ http://purl.uniprot.org/uniprot/M3WYE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9685:CACNG7 ^@ http://purl.uniprot.org/uniprot/M3VWV7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. http://togogenome.org/gene/9685:FLOT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNG0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/9685:GABRG2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2A5|||http://purl.uniprot.org/uniprot/A0A2I2UNR3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A2I2UJQ5|||http://purl.uniprot.org/uniprot/A0A2I2UVD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9685:MED9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UN39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:DIPK2A ^@ http://purl.uniprot.org/uniprot/M3X2C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9685:RBM10 ^@ http://purl.uniprot.org/uniprot/M3VWK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PSPC1 ^@ http://purl.uniprot.org/uniprot/M3X0A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PSPC family.|||Cytoplasm|||Nucleus matrix|||Nucleus speckle|||nucleolus http://togogenome.org/gene/9685:HDAC3 ^@ http://purl.uniprot.org/uniprot/M3W6Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9685:B3GAT3 ^@ http://purl.uniprot.org/uniprot/M3WAD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:EGR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/9685:DENND6B ^@ http://purl.uniprot.org/uniprot/M3WG02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/9685:MYH7B ^@ http://purl.uniprot.org/uniprot/M3VY99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||myofibril http://togogenome.org/gene/9685:LOC101098543 ^@ http://purl.uniprot.org/uniprot/M3X3H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NPM3 ^@ http://purl.uniprot.org/uniprot/M3W794 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9685:FAM76A ^@ http://purl.uniprot.org/uniprot/A0A2I2UMN0 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9685:RARS2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7G2|||http://purl.uniprot.org/uniprot/A0A5F5XV42 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:AATF ^@ http://purl.uniprot.org/uniprot/A0A337SSM5 ^@ Similarity ^@ Belongs to the AATF family. http://togogenome.org/gene/9685:ACLY ^@ http://purl.uniprot.org/uniprot/A0A337SMT2|||http://purl.uniprot.org/uniprot/M3VXZ1 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/9685:CROT ^@ http://purl.uniprot.org/uniprot/M3X8A3 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9685:TAFAZZIN ^@ http://purl.uniprot.org/uniprot/M3X025 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:SLC27A5 ^@ http://purl.uniprot.org/uniprot/M3W0W6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:PHF1 ^@ http://purl.uniprot.org/uniprot/A0A337S4E6|||http://purl.uniprot.org/uniprot/A0A5F5Y057 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9685:PCOLCE ^@ http://purl.uniprot.org/uniprot/A0A5F5XK05|||http://purl.uniprot.org/uniprot/M3W6K9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:CD6 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZ00|||http://purl.uniprot.org/uniprot/M3WJ99 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:TRPC1 ^@ http://purl.uniprot.org/uniprot/M3WX01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.|||Membrane|||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. http://togogenome.org/gene/9685:AARS1 ^@ http://purl.uniprot.org/uniprot/M3XF55 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9685:LOC101095773 ^@ http://purl.uniprot.org/uniprot/M3WRN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:MED24 ^@ http://purl.uniprot.org/uniprot/M3WLR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9685:PDE6D ^@ http://purl.uniprot.org/uniprot/A0A2I2V1R8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9685:TATDN3 ^@ http://purl.uniprot.org/uniprot/A0A337SLJ7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9685:ACOT8 ^@ http://purl.uniprot.org/uniprot/M3VXG9 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9685:PDCL3 ^@ http://purl.uniprot.org/uniprot/M3X7S3 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9685:MRPS10 ^@ http://purl.uniprot.org/uniprot/A0A337SE50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/9685:FGF6 ^@ http://purl.uniprot.org/uniprot/M3VU59 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9685:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9685:SAR1B ^@ http://purl.uniprot.org/uniprot/M3VUK3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9685:CD8A ^@ http://purl.uniprot.org/uniprot/P41688 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Forms disulfide-linked heterodimers with CD8B at the cell surface. Forms also homodimers in several cell types including NK-cells or peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.|||Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.|||O-glycosylated.|||Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.|||Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation. http://togogenome.org/gene/9685:CASQ2 ^@ http://purl.uniprot.org/uniprot/M3XE43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9685:CUTA ^@ http://purl.uniprot.org/uniprot/A0A2I2UJG2 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/9685:DDIT4 ^@ http://purl.uniprot.org/uniprot/M3WWJ2 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9685:LIPK ^@ http://purl.uniprot.org/uniprot/M3W797 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9685:SCO1 ^@ http://purl.uniprot.org/uniprot/M3WXX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCO1/2 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:CKS1B ^@ http://purl.uniprot.org/uniprot/A0A2I2U3K5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9685:SLC46A3 ^@ http://purl.uniprot.org/uniprot/M3W974 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:VPS18 ^@ http://purl.uniprot.org/uniprot/M3WL77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/9685:ALDH7A1 ^@ http://purl.uniprot.org/uniprot/M3XAZ0 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9685:SDHD ^@ http://purl.uniprot.org/uniprot/M3XAM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9685:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/M3WIT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/9685:TMED5 ^@ http://purl.uniprot.org/uniprot/A0A337S1K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9685:CTSC ^@ http://purl.uniprot.org/uniprot/M3W9M0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Lysosome|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/9685:GATB ^@ http://purl.uniprot.org/uniprot/A0A5F5XNJ7|||http://purl.uniprot.org/uniprot/M3VZX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9685:LOC101094135 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:PGBD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ARL5B ^@ http://purl.uniprot.org/uniprot/M3WMQ6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9685:DHDDS ^@ http://purl.uniprot.org/uniprot/M3WHN3 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9685:METTL14 ^@ http://purl.uniprot.org/uniprot/M3W713 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. http://togogenome.org/gene/9685:KIF3C ^@ http://purl.uniprot.org/uniprot/M3WMZ5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:SRP54 ^@ http://purl.uniprot.org/uniprot/M3WSB2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/9685:BOK ^@ http://purl.uniprot.org/uniprot/M3WKE8 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9685:ACTG2 ^@ http://purl.uniprot.org/uniprot/M3WGC1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:COA3 ^@ http://purl.uniprot.org/uniprot/M3WIA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.|||Membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/9685:GALNT5 ^@ http://purl.uniprot.org/uniprot/M3W7T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:FN3K ^@ http://purl.uniprot.org/uniprot/M3WJX9 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9685:PPA2 ^@ http://purl.uniprot.org/uniprot/M3XD71 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/9685:RPS3 ^@ http://purl.uniprot.org/uniprot/M3WG22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||spindle http://togogenome.org/gene/9685:G6PC3 ^@ http://purl.uniprot.org/uniprot/M3VY26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:TARBP2 ^@ http://purl.uniprot.org/uniprot/M3W8A9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Nucleus|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).|||perinuclear region http://togogenome.org/gene/9685:LHFPL5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UET4|||http://purl.uniprot.org/uniprot/A0A5F5Y450 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101095073 ^@ http://purl.uniprot.org/uniprot/M3XEZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LPL ^@ http://purl.uniprot.org/uniprot/P55031 ^@ Activity Regulation|||Disease Annotation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Defects in LPL are a cause of chylomicronemia syndrome, also known as type I hyperlipoproteinemia. Animals exhibit reduced body mass, growth rates, and increased stillbirth rates.|||Homodimer. Interacts with GPIHBP1 with 1:1 stoichiometry (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interaction with heparan sulfate proteoglycans is required to protect LPL against loss of activity. Associates with lipoprotein particles in blood plasma. Interacts with LMF1 and SEL1L; interaction with SEL1L is required to prevent aggregation of newly synthesized LPL in the endoplasmic reticulum (ER), and for normal export of LPL from the ER to the extracellular space (By similarity). Interacts with SORL1; SORL1 acts as a sorting receptor, promoting LPL localization to endosomes and later to lysosomes, leading to degradation of newly synthesized LPL (By similarity).|||Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:8636438). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).|||Secreted|||The apolipoprotein APOC2 acts as a coactivator of LPL activity (By similarity). Ca(2+) binding promotes protein stability and formation of the active homodimer. Interaction with GPIHBP1 protects LPL against inactivation by ANGPTL4 (By similarity).|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9685:HNRNPR ^@ http://purl.uniprot.org/uniprot/A0A2I2UFR7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:KRR1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y5L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/9685:FAM124B ^@ http://purl.uniprot.org/uniprot/A0A337RZG3 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9685:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U6I6|||http://purl.uniprot.org/uniprot/M3X5W3 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9685:FAR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2US82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9685:GNB2 ^@ http://purl.uniprot.org/uniprot/M3X5T9 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9685:B3GNT3 ^@ http://purl.uniprot.org/uniprot/A0A337SI96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:CCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UN43|||http://purl.uniprot.org/uniprot/A0A5F5XNL6|||http://purl.uniprot.org/uniprot/M3W1A0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:LOC101099411 ^@ http://purl.uniprot.org/uniprot/M3X7T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:STAR ^@ http://purl.uniprot.org/uniprot/F5CT15 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9685:IER2 ^@ http://purl.uniprot.org/uniprot/M3VUV2 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/9685:LOC101080332 ^@ http://purl.uniprot.org/uniprot/A0A341ZMG9 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9685:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MQ00|||http://purl.uniprot.org/uniprot/Q95L97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ (Microbial infection) Functions as a retroviral receptor for feline leukemia virus subgroup B (FeLV-B).|||Apical cell membrane|||Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Cell membrane|||Homodimer.|||Membrane|||Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization. Required to maintain normal cerebrospinal fluid phosphate levels. Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity).|||Sodium-phosphate symporter. http://togogenome.org/gene/9685:RPL15 ^@ http://purl.uniprot.org/uniprot/M3X6G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Cytoplasm http://togogenome.org/gene/9685:CCNG2 ^@ http://purl.uniprot.org/uniprot/M3X0F9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:CCK ^@ http://purl.uniprot.org/uniprot/M3W5D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/9685:MPEG1 ^@ http://purl.uniprot.org/uniprot/M3WGU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9685:MTHFR ^@ http://purl.uniprot.org/uniprot/M3VU14 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/9685:VSIG1 ^@ http://purl.uniprot.org/uniprot/A0A337SG69|||http://purl.uniprot.org/uniprot/M3XAU7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101098304 ^@ http://purl.uniprot.org/uniprot/M3W2E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CFAP299 ^@ http://purl.uniprot.org/uniprot/M3WXK8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/9685:COX8A ^@ http://purl.uniprot.org/uniprot/M3WL37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:CCNE2 ^@ http://purl.uniprot.org/uniprot/M3X5A2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:RDH12 ^@ http://purl.uniprot.org/uniprot/M3WK23 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:EFNB3 ^@ http://purl.uniprot.org/uniprot/B0LDT1 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:NINJ2 ^@ http://purl.uniprot.org/uniprot/A0A337SQL8|||http://purl.uniprot.org/uniprot/M3WAH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9685:GJB3 ^@ http://purl.uniprot.org/uniprot/A0A654IEE2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:ANPEP ^@ http://purl.uniprot.org/uniprot/P79171 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ (Microbial infection) In case of feline coronavirus (FCoV) infection, serves as a receptor for FCoV spike glycoprotein. It is as well a receptor for other serogroup I coronaviruses, like canine coronavirus (CCoV), porcine transmissible gastroenteritis virus (TGEV), and human coronavirus 229E (HCoV-229E). Also serves as a receptor for infectious bronchitis virus (IBV, Arkansas 99 serotype) in serogroup III.|||(Microbial infection) Interacts with FCoV, CCoV, TGEV and HCoV-229E spike glycoprotein.|||Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).|||Cell membrane|||Homodimer. Interacts with SLC6A19 (By similarity).|||May undergo proteolysis and give rise to a soluble form.|||N- and O-glycosylated.|||Sulfated. http://togogenome.org/gene/9685:CAMK2A ^@ http://purl.uniprot.org/uniprot/A0A2I2V4I2|||http://purl.uniprot.org/uniprot/M3W0P7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9685:MYO1D ^@ http://purl.uniprot.org/uniprot/M3WGW9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9685:ERLEC1 ^@ http://purl.uniprot.org/uniprot/A0A337S9P7|||http://purl.uniprot.org/uniprot/M3WIQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9685:SUCLA2 ^@ http://purl.uniprot.org/uniprot/M3WQ50 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.|||Mitochondrion http://togogenome.org/gene/9685:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIQ7|||http://purl.uniprot.org/uniprot/A0A2I2UWS2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.|||Secreted http://togogenome.org/gene/9685:NPC1L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U310|||http://purl.uniprot.org/uniprot/M3WCY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9685:MCM2 ^@ http://purl.uniprot.org/uniprot/M3WJ18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9685:AQP7 ^@ http://purl.uniprot.org/uniprot/A0A337S127 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PPP1R2 ^@ http://purl.uniprot.org/uniprot/M3WWT7 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9685:GGCX ^@ http://purl.uniprot.org/uniprot/A0A2I2UMV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:OSBPL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UB70 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9685:AOC1 ^@ http://purl.uniprot.org/uniprot/M3XC22 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9685:PAFAH1B1 ^@ http://purl.uniprot.org/uniprot/B0LSW3 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts with the catalytic dimer of PAF-AH (I) heterotetrameric enzyme: interacts with PAFAH1B2 homodimer (alpha2/alpha2 homodimer), PAFAH1B3 homodimer (alpha1/alpha1 homodimer) and PAFAH1B2-PAFAH1B3 heterodimer (alpha2/alpha1 heterodimer) (By similarity). Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Interacts with INTS13. Interacts with DCDC1.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Nucleus membrane|||Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).|||Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).|||centrosome|||cytoskeleton|||spindle http://togogenome.org/gene/9685:MIGA2 ^@ http://purl.uniprot.org/uniprot/M3W4V9 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/9685:NHP2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XS68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9685:CDK15 ^@ http://purl.uniprot.org/uniprot/M3VUX8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:LOC101101632 ^@ http://purl.uniprot.org/uniprot/A0A337S7Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GJE1 ^@ http://purl.uniprot.org/uniprot/A0A337SPI7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UW97 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9685:LIMS1 ^@ http://purl.uniprot.org/uniprot/A0A337SJ16 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9685:CD5 ^@ http://purl.uniprot.org/uniprot/M3WJA0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LOC101093519 ^@ http://purl.uniprot.org/uniprot/M3WY36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:ISOC2 ^@ http://purl.uniprot.org/uniprot/M3W4G2 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/9685:VTI1B ^@ http://purl.uniprot.org/uniprot/M3WK20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9685:LOC101085496 ^@ http://purl.uniprot.org/uniprot/M3WY89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101095546 ^@ http://purl.uniprot.org/uniprot/A0A5F5XFE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/A0M8T5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.|||Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.|||cell cortex|||dendritic spine http://togogenome.org/gene/9685:ACTB ^@ http://purl.uniprot.org/uniprot/M3WRZ7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:IPO9 ^@ http://purl.uniprot.org/uniprot/M3VUS3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:EPS8L3 ^@ http://purl.uniprot.org/uniprot/M3WMX1 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9685:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9685:LIPT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9H5 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/9685:UFL1 ^@ http://purl.uniprot.org/uniprot/M3W8F2 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/9685:RFC5 ^@ http://purl.uniprot.org/uniprot/M3VY75 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9685:LOC101085786 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0I5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family. http://togogenome.org/gene/9685:CACNG4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UA66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. http://togogenome.org/gene/9685:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7L5|||http://purl.uniprot.org/uniprot/A0A2I2UNB0 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9685:RGS2 ^@ http://purl.uniprot.org/uniprot/M3X7Y3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||nucleolus http://togogenome.org/gene/9685:STK11 ^@ http://purl.uniprot.org/uniprot/M3WJD3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. http://togogenome.org/gene/9685:MRPL3 ^@ http://purl.uniprot.org/uniprot/M3W5Q4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9685:TRNT1 ^@ http://purl.uniprot.org/uniprot/M3X159 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9685:DGKA ^@ http://purl.uniprot.org/uniprot/M3WJU2 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic diacylglycerol kinase family.|||Monomer. http://togogenome.org/gene/9685:LOC101100998 ^@ http://purl.uniprot.org/uniprot/M3WWB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PAX5 ^@ http://purl.uniprot.org/uniprot/M3VX00 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:MSMP ^@ http://purl.uniprot.org/uniprot/M3WPH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9685:TAF7 ^@ http://purl.uniprot.org/uniprot/A0A337RTM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/9685:STRADB ^@ http://purl.uniprot.org/uniprot/M3XGB4 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9685:NFYB ^@ http://purl.uniprot.org/uniprot/A0A2I2U0F1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9685:TFF2 ^@ http://purl.uniprot.org/uniprot/B4X8D8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:MALSU1 ^@ http://purl.uniprot.org/uniprot/M3XAK6 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/9685:COX4I2 ^@ http://purl.uniprot.org/uniprot/M3WL40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101098667 ^@ http://purl.uniprot.org/uniprot/M3X3R6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PHKA1 ^@ http://purl.uniprot.org/uniprot/M3W753 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9685:THY1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGV7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:NRDC ^@ http://purl.uniprot.org/uniprot/M3X115 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9685:NDST3 ^@ http://purl.uniprot.org/uniprot/M3W3G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9685:THOC6 ^@ http://purl.uniprot.org/uniprot/A0A337SCP3 ^@ Similarity ^@ Belongs to the WD repeat THOC6 family. http://togogenome.org/gene/9685:LRP1 ^@ http://purl.uniprot.org/uniprot/M3VU91|||http://purl.uniprot.org/uniprot/M3X7K5 ^@ Caution|||Similarity ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CYBB ^@ http://purl.uniprot.org/uniprot/M3VZS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PIGW ^@ http://purl.uniprot.org/uniprot/M3WSJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/9685:PKM ^@ http://purl.uniprot.org/uniprot/A0A337S4I7 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9685:GATM ^@ http://purl.uniprot.org/uniprot/M3X5Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Homodimer.|||Mitochondrion inner membrane|||Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain. http://togogenome.org/gene/9685:BECN1 ^@ http://purl.uniprot.org/uniprot/M3WIA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9685:ELAPOR1 ^@ http://purl.uniprot.org/uniprot/M3WM91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SLC25A24 ^@ http://purl.uniprot.org/uniprot/M3VW64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:TFAP2C ^@ http://purl.uniprot.org/uniprot/A0A5F5XG34 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9685:CRYBB3 ^@ http://purl.uniprot.org/uniprot/M3WJG8 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:TMEM251 ^@ http://purl.uniprot.org/uniprot/M3X151 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LYSET family.|||Membrane http://togogenome.org/gene/9685:YTHDF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ31 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9685:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0V8 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9685:ELN ^@ http://purl.uniprot.org/uniprot/A0A5F5XF99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elastin family.|||Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle.|||extracellular matrix http://togogenome.org/gene/9685:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A2I2U4K6|||http://purl.uniprot.org/uniprot/A0A337S783 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9685:HMBS ^@ http://purl.uniprot.org/uniprot/D3W810|||http://purl.uniprot.org/uniprot/D3W812 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/9685:NGLY1 ^@ http://purl.uniprot.org/uniprot/A0A337S594|||http://purl.uniprot.org/uniprot/A0A337S5I9|||http://purl.uniprot.org/uniprot/M3WX23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Cytoplasm|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. http://togogenome.org/gene/9685:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/M3XAE8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:RPF1 ^@ http://purl.uniprot.org/uniprot/M3WXF9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9685:AMACR ^@ http://purl.uniprot.org/uniprot/M3WPD9 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/9685:PAX3 ^@ http://purl.uniprot.org/uniprot/M3WNW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9685:MRPL13 ^@ http://purl.uniprot.org/uniprot/A0A5F5XG25 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9685:SERPINA4 ^@ http://purl.uniprot.org/uniprot/M3WCX4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A2I2UEL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:AMPD1 ^@ http://purl.uniprot.org/uniprot/M3WDE5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9685:MSN ^@ http://purl.uniprot.org/uniprot/M3WJI8 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton|||microvillus http://togogenome.org/gene/9685:LOC101081818 ^@ http://purl.uniprot.org/uniprot/M3X984 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SUCLG1 ^@ http://purl.uniprot.org/uniprot/M3W3J5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/9685:KAT8 ^@ http://purl.uniprot.org/uniprot/M3VYT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9685:TEKT1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XVW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9685:SCNN1A ^@ http://purl.uniprot.org/uniprot/A0A2I2URC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/M3VV92 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/9685:TSFM ^@ http://purl.uniprot.org/uniprot/M3X1M8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/9685:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3C2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Golgi stack membrane|||Membrane|||Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. http://togogenome.org/gene/9685:BMP3 ^@ http://purl.uniprot.org/uniprot/M3W8F5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9685:STAM ^@ http://purl.uniprot.org/uniprot/M3XDT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9685:LOC101083031 ^@ http://purl.uniprot.org/uniprot/M3WDM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101088501 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101081393 ^@ http://purl.uniprot.org/uniprot/M3XDF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PRKAR1B ^@ http://purl.uniprot.org/uniprot/M3X8Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:USP37 ^@ http://purl.uniprot.org/uniprot/M3VYE7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9685:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y0R9|||http://purl.uniprot.org/uniprot/M3WNM7 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9685:GNG3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9685:DPYSL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQR1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9685:RNF20 ^@ http://purl.uniprot.org/uniprot/M3VWL4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9685:BCHE ^@ http://purl.uniprot.org/uniprot/O62760 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type-B carboxylesterase/lipase family.|||Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity).|||Homotetramer; disulfide-linked. Dimer of dimers (By similarity).|||Secreted http://togogenome.org/gene/9685:NXPH1 ^@ http://purl.uniprot.org/uniprot/M3W6B2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9685:MDH2 ^@ http://purl.uniprot.org/uniprot/K0J107 ^@ Activity Regulation|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Acetylation is enhanced after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation.|||Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Enzyme activity is enhanced by acetylation.|||Homodimer.|||Mitochondrion matrix|||Ubiquitously expressed. Highly expressed in skeletal muscle and heart. Also expressed in liver, ileum, colon, kidney and adipose tissue, and at very low levels in lung, pancreas, stomach and spleen. http://togogenome.org/gene/9685:CLDN17 ^@ http://purl.uniprot.org/uniprot/M3WXT4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:FAM3C ^@ http://purl.uniprot.org/uniprot/M3WVJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9685:MRPL52 ^@ http://purl.uniprot.org/uniprot/M3W680 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL52 family.|||Mitochondrion http://togogenome.org/gene/9685:TMCC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQW8 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9685:ABAT ^@ http://purl.uniprot.org/uniprot/M3WQN5 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9685:LOC101091078 ^@ http://purl.uniprot.org/uniprot/M3X708 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101092141 ^@ http://purl.uniprot.org/uniprot/M3WEB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PDE1C ^@ http://purl.uniprot.org/uniprot/M3VUB1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:KCNB1 ^@ http://purl.uniprot.org/uniprot/M3WBK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||dendrite|||sarcolemma|||synaptosome http://togogenome.org/gene/9685:LOC101091370 ^@ http://purl.uniprot.org/uniprot/M3X2Y2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9685:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A2I2UHH9|||http://purl.uniprot.org/uniprot/M3WEC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9685:ABHD2 ^@ http://purl.uniprot.org/uniprot/M3WHT2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9685:PCID2 ^@ http://purl.uniprot.org/uniprot/A0A337SHN9|||http://purl.uniprot.org/uniprot/M3WKC8 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/9685:CD8B ^@ http://purl.uniprot.org/uniprot/P79336 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Forms disulfide-linked heterodimers with CD8A at the cell surface. Interacts with CD3D; this interaction couples TCR-CD3 with CD8. Interacts with LCK.|||Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.|||Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers.|||Phosphorylated as a consequence of T-cell activation. http://togogenome.org/gene/9685:ANXA13 ^@ http://purl.uniprot.org/uniprot/M3WDB9 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9685:CDKN1A ^@ http://purl.uniprot.org/uniprot/O19002 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity).|||Belongs to the CDI family.|||Cytoplasm|||Interacts with HDAC1; the interaction is prevented by competitive binding of C10orf90/FATS to HDAC1 facilitating acetylation and protein stabilization of CDKN1A/p21 (By similarity). Interacts with MKRN1. Interacts with PSMA3. Interacts with PCNA. Component of the ternary complex, cyclin D-CDK4-CDKN1A. Interacts (via its N-terminal domain) with CDK4; the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4. Binding to CDK2 leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Interacts with PIM1. Interacts with STK11 and NUAK1 (By similarity). Interacts with DTL and TRIM39 (By similarity).|||May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity).|||Nucleus|||Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. Phosphorylation at Ser-114 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-145 by PIM2 enhances protein stability and inhibits cell proliferation. Phosphorylation of Thr-145 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. UV radiation-induced phosphorylation at Ser-146 by NUAK1 leads to its degradation.|||The C-terminal is required for nuclear localization of the cyclin D-CDK4 complex.|||The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.|||Ubiquitinated by MKRN1; leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Ubiquitination at Ser-2 leads to degradation by the proteasome pathway. Ubiquitinated by RNF114; leading to proteasomal degradation (By similarity). http://togogenome.org/gene/9685:LOC101089023 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:OAS2 ^@ http://purl.uniprot.org/uniprot/M3VUJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9685:TLCD4 ^@ http://purl.uniprot.org/uniprot/M3WTX6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:EFNA5 ^@ http://purl.uniprot.org/uniprot/A0A337S0H8|||http://purl.uniprot.org/uniprot/A0A337SUS6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:STX10 ^@ http://purl.uniprot.org/uniprot/M3VUV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9685:LOC101092025 ^@ http://purl.uniprot.org/uniprot/M3XAG6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:SERPINA11 ^@ http://purl.uniprot.org/uniprot/M3WCX2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:TRAK1 ^@ http://purl.uniprot.org/uniprot/A0A337SDJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9685:CD1H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7D8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9685:AIMP2 ^@ http://purl.uniprot.org/uniprot/M3X664 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/9685:TRABD2B ^@ http://purl.uniprot.org/uniprot/M3WQ16 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. http://togogenome.org/gene/9685:SLC26A5 ^@ http://purl.uniprot.org/uniprot/B5TGH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Voltage-sensitive motor protein that drives outer hair cell (OHC) electromotility (eM) and participates in sound amplification in the hearing organ. Converts changes in the transmembrane electric potential into mechanical displacements resulting in the coupling of its expansion to movement of a charged voltage sensor across the lipid membrane. The nature of the voltage sensor is not completely clear, and two models compete. In the first model, acts as an incomplete transporter where intracellular chloride anion acts as extrinsic voltage sensor that drives conformational change in the protein which is sufficient to produce a length change in the plane of the membrane and hence in the length of the OHC. The second model in which multiple charged amino acid residues are distributed at the intracellular and extracellular membrane interfaces that form an intrinsic voltage sensor, whose movement produces the non-linear capacitance (NLC). However, the effective voltage sensor may be the result of a hybrid voltage sensor, assembled from intrinsic charge (charged residues) and extrinsic charge (bound anion). Notably, binding of anions to the anion-binding pocket partially neutralizes the intrinsic positive charge rather than to form an electrically negative sensor, therefore remaining charge may serve as voltage sensor that, after depolarization, moves from down (expanded state) to up (contracted) conformation, which is accompanied by an eccentric contraction of the intermembrane cross-sectional area of the protein as well as a major increase in the hydrophobic thickness of the protein having as consequences the plasma membrane thickening and the cell contraction after membrane depolarization. The anion-binding pocket transits from the inward-open (Down) state, where it is exposed toward the intracellular solvent in the absence of anion, to the occluded (Up) state upon anion binding. Salicylate competes for the anion-binding site and inhibits the voltage-sensor movement, and therefore inhibits the charge transfer and electromotility by displacing Cl(-) from the anion-binding site and by preventing the structural transitions to the contracted state. In addition, can act as a weak Cl(-)/HCO3(-) antiporter across the cell membrane and so regulate the intracellular pH of the outer hair cells (OHCs), while firstly found as being unable to mediate electrogenic anion transport. Moreover, supports a role in cardiac mechanical amplification serving as an elastic element to enhance the actomyosin- based sarcomere contraction system. http://togogenome.org/gene/9685:DUT ^@ http://purl.uniprot.org/uniprot/A0A337RVJ5 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/9685:DPEP3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XE00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ZSCAN31 ^@ http://purl.uniprot.org/uniprot/A0A5F5XMM8|||http://purl.uniprot.org/uniprot/M3VUC4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:GH1 ^@ http://purl.uniprot.org/uniprot/P46404 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.|||Secreted http://togogenome.org/gene/9685:ADH5 ^@ http://purl.uniprot.org/uniprot/M3W3A3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/9685:CSK ^@ http://purl.uniprot.org/uniprot/M3VUK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9685:LOC101094100 ^@ http://purl.uniprot.org/uniprot/M3XFM3 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:AP2M1 ^@ http://purl.uniprot.org/uniprot/M3W8D5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||coated pit http://togogenome.org/gene/9685:PMS1 ^@ http://purl.uniprot.org/uniprot/M3WMQ3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9685:EIF3F ^@ http://purl.uniprot.org/uniprot/A0A2I2US80 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit F family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9685:NEIL1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XMH4|||http://purl.uniprot.org/uniprot/M3WEZ0 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/9685:ELK1 ^@ http://purl.uniprot.org/uniprot/M3W951 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:RPL34 ^@ http://purl.uniprot.org/uniprot/M3WMR1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9685:MDH1 ^@ http://purl.uniprot.org/uniprot/Q7YRU4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation.|||Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).|||Homodimer.|||ISGylated.|||cytosol http://togogenome.org/gene/9685:RRAGD ^@ http://purl.uniprot.org/uniprot/M3X3N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9685:KCNE3 ^@ http://purl.uniprot.org/uniprot/M3W8P2 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9685:IRF7 ^@ http://purl.uniprot.org/uniprot/A0A337S7B8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:IFRD1 ^@ http://purl.uniprot.org/uniprot/M3X558 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9685:IZUMO2 ^@ http://purl.uniprot.org/uniprot/M3W8Q8 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9685:LOC105260451 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GPATCH11 ^@ http://purl.uniprot.org/uniprot/A0A5F5XYY2 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/9685:DLX5 ^@ http://purl.uniprot.org/uniprot/A0A337S076 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9685:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/M3X2S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:TIMM8A ^@ http://purl.uniprot.org/uniprot/M3X1J7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9685:ACTN3 ^@ http://purl.uniprot.org/uniprot/M3W478 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9685:LOC101096601 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQ81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GFUS ^@ http://purl.uniprot.org/uniprot/M3VVW7 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/9685:RIDA ^@ http://purl.uniprot.org/uniprot/A0A2I2UD52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.|||Peroxisome http://togogenome.org/gene/9685:ZCCHC4 ^@ http://purl.uniprot.org/uniprot/M3X3T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9685:TUBB1 ^@ http://purl.uniprot.org/uniprot/B5LX42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9685:WSCD2 ^@ http://purl.uniprot.org/uniprot/M3WE46 ^@ Function|||Similarity ^@ Belongs to the WSCD family.|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9685:UBAP2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XYK4|||http://purl.uniprot.org/uniprot/A0A5F5Y5K4|||http://purl.uniprot.org/uniprot/M3WBX0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:UCP1 ^@ http://purl.uniprot.org/uniprot/M3WAF9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:MAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9K7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/9685:NAPG ^@ http://purl.uniprot.org/uniprot/M3X184 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9685:PGM1 ^@ http://purl.uniprot.org/uniprot/M3WVK0 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9685:DUOXA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9685:NHS ^@ http://purl.uniprot.org/uniprot/A0A2I2UXH0|||http://purl.uniprot.org/uniprot/M3VU89 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/9685:ZFP36L1 ^@ http://purl.uniprot.org/uniprot/M3XB27 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9685:ZP2 ^@ http://purl.uniprot.org/uniprot/P47984 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZP domain family. ZPA subfamily.|||Can form homopolymers that assemble into long fibers (in vitro). Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP3.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.|||N-glycosylated.|||O-glycosylated; contains sulfate-substituted glycans.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/9685:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNA8|||http://purl.uniprot.org/uniprot/A0A337S6S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9685:SLC6A5 ^@ http://purl.uniprot.org/uniprot/M3WZR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9685:LAPTM4A ^@ http://purl.uniprot.org/uniprot/A0A2I2U8M7 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9685:POLD2 ^@ http://purl.uniprot.org/uniprot/M3WKK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Nucleus http://togogenome.org/gene/9685:XRN2 ^@ http://purl.uniprot.org/uniprot/M3W8Q9 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/9685:WDR24 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR24 family.|||Lysosome membrane http://togogenome.org/gene/9685:ZPR1 ^@ http://purl.uniprot.org/uniprot/M3WFW8 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/9685:LOC101082481 ^@ http://purl.uniprot.org/uniprot/M3XFU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MOG ^@ http://purl.uniprot.org/uniprot/A0A337SU08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/9685:LOC101099693 ^@ http://purl.uniprot.org/uniprot/M3XAA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TTC21B ^@ http://purl.uniprot.org/uniprot/M3W8I9 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/9685:ARVCF ^@ http://purl.uniprot.org/uniprot/A0A2I2UM81|||http://purl.uniprot.org/uniprot/A0A2I2UNP3 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9685:OSBPL10 ^@ http://purl.uniprot.org/uniprot/M3W8W3 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9685:TMEM107 ^@ http://purl.uniprot.org/uniprot/A0A2I2UH78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:UBA1 ^@ http://purl.uniprot.org/uniprot/M3VWK3 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9685:PIGK ^@ http://purl.uniprot.org/uniprot/M3X6D5 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/9685:SLC5A1 ^@ http://purl.uniprot.org/uniprot/E1AWN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SIDT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V064|||http://purl.uniprot.org/uniprot/M3W303 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/9685:STX16 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJA1 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9685:TAC3 ^@ http://purl.uniprot.org/uniprot/M3WKX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/9685:LOC101099332 ^@ http://purl.uniprot.org/uniprot/A0A2I2V171 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9685:RAB3C ^@ http://purl.uniprot.org/uniprot/A0A2I2U435|||http://purl.uniprot.org/uniprot/A0A2I2V5I7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9685:NAF1 ^@ http://purl.uniprot.org/uniprot/M3XCR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/9685:SERPING1 ^@ http://purl.uniprot.org/uniprot/M3W683 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:AVPR1B ^@ http://purl.uniprot.org/uniprot/M3W6E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9685:DYNLRB2 ^@ http://purl.uniprot.org/uniprot/M3W1J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9685:NPC2 ^@ http://purl.uniprot.org/uniprot/M3X1L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPC2 family.|||Secreted http://togogenome.org/gene/9685:SEBOX ^@ http://purl.uniprot.org/uniprot/M3W9I4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC554344 ^@ http://purl.uniprot.org/uniprot/Q5KR53 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.|||Membrane|||Microsome membrane|||Mitochondrion inner membrane|||The omega-1 hydroxylase activity is stimulated by cytochrome b5. http://togogenome.org/gene/9685:DNAAF6 ^@ http://purl.uniprot.org/uniprot/M3WVM8 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9685:SCAMP1 ^@ http://purl.uniprot.org/uniprot/M3W8E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9685:ZKSCAN5 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y5I2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:IFI44 ^@ http://purl.uniprot.org/uniprot/M3XE59 ^@ Similarity ^@ Belongs to the IFI44 family. http://togogenome.org/gene/9685:MED23 ^@ http://purl.uniprot.org/uniprot/A0A2I2UME4|||http://purl.uniprot.org/uniprot/M3WA80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/9685:ZC3HAV1 ^@ http://purl.uniprot.org/uniprot/M3X2R1 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9685:RNF40 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAJ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9685:SULT1B1 ^@ http://purl.uniprot.org/uniprot/M3W895 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9685:HACL1 ^@ http://purl.uniprot.org/uniprot/A0A337SXX1 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9685:ANKRD34B ^@ http://purl.uniprot.org/uniprot/M3X2M2 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9685:LOC101088096 ^@ http://purl.uniprot.org/uniprot/A0A2I2UA77 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9685:CAPN7 ^@ http://purl.uniprot.org/uniprot/M3XEV5 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9685:ROR2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XV24 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:SDHC ^@ http://purl.uniprot.org/uniprot/M3VUW0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9685:GPAT4 ^@ http://purl.uniprot.org/uniprot/A0A337SQZ9|||http://purl.uniprot.org/uniprot/M3WHX9 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9685:CUL5 ^@ http://purl.uniprot.org/uniprot/G1FQD7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9685:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/M3XAY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9685:PLA2G4E ^@ http://purl.uniprot.org/uniprot/A0A5F5XLL6|||http://purl.uniprot.org/uniprot/M3W7K6 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9685:ELOC ^@ http://purl.uniprot.org/uniprot/F8V3I9 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9685:DOK2 ^@ http://purl.uniprot.org/uniprot/M3WAJ3 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9685:CZIB ^@ http://purl.uniprot.org/uniprot/M3XEK6 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9685:LOC101099942 ^@ http://purl.uniprot.org/uniprot/M3XEU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:EPYC ^@ http://purl.uniprot.org/uniprot/M3XF62 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9685:B3GNT8 ^@ http://purl.uniprot.org/uniprot/M3W424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:LOC101093829 ^@ http://purl.uniprot.org/uniprot/M3X3S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101088423 ^@ http://purl.uniprot.org/uniprot/M3WSM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:RAP2B ^@ http://purl.uniprot.org/uniprot/M3W509 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9685:VMA21 ^@ http://purl.uniprot.org/uniprot/A0A2I2V587 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/9685:RAB4B ^@ http://purl.uniprot.org/uniprot/M3WTP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9685:ECH1 ^@ http://purl.uniprot.org/uniprot/M3VZV7 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9685:DPM2 ^@ http://purl.uniprot.org/uniprot/M3WRG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/9685:FEZ1 ^@ http://purl.uniprot.org/uniprot/M3WVR5 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/9685:LOC101096439 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9685:LOC101090590 ^@ http://purl.uniprot.org/uniprot/M3XB84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101095283 ^@ http://purl.uniprot.org/uniprot/A0A337RZH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DDIT3 ^@ http://purl.uniprot.org/uniprot/M3VXV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Cytoplasm http://togogenome.org/gene/9685:APOA5 ^@ http://purl.uniprot.org/uniprot/A0A337S8I7 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9685:F9 ^@ http://purl.uniprot.org/uniprot/Q6SA95 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease.|||Belongs to the peptidase S1 family.|||Calcium binds to the gamma-carboxyglutamic acid (Gla) residues in the Gla domain. Calcium can also bind, with stronger affinity, to another site beyond the Gla domain. Under physiological ion concentrations, Ca(2+) is displaced by Mg(2+) from some of the gammaglutamate residues in the N-terminal Gla domain. This leads to a subtle conformation change that may affect the interaction with its binding protein.|||Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.|||Heterodimer of a light chain and a heavy chain; disulfide-linked. Interacts with SERPINC1.|||Predominantly O-glucosylated at Ser-99 by POGLUT1 in vitro.|||Secreted|||The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. http://togogenome.org/gene/9685:EVL ^@ http://purl.uniprot.org/uniprot/A0A5F5XI87|||http://purl.uniprot.org/uniprot/A0A5F5XWN3|||http://purl.uniprot.org/uniprot/M3XED8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||cytoskeleton http://togogenome.org/gene/9685:P2RY13 ^@ http://purl.uniprot.org/uniprot/A0A337SNR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PMP2 ^@ http://purl.uniprot.org/uniprot/M3W3Q6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family.|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/9685:LOC101098412 ^@ http://purl.uniprot.org/uniprot/M3X8R4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:HCRTR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U878 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SHMT2 ^@ http://purl.uniprot.org/uniprot/M3VU92 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9685:MIOX ^@ http://purl.uniprot.org/uniprot/M3WI29 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol oxygenase family.|||Binds 2 iron ions per subunit.|||Cytoplasm http://togogenome.org/gene/9685:AGXT ^@ http://purl.uniprot.org/uniprot/P41689 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism.|||Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification.|||Homodimer.|||Mitochondrion matrix|||Peroxisome|||The intracellular compartmentalization of AGTX in mammalian hepatocytes is species dependent. In human and rabbit, AGTX is peroxisomal. In new world monkeys (marmoset) and rodents (rat and mouse), it is distributed approximately evenly between peroxisomes and mitochondria. In carnivores, like cat, the great majority of the enzyme is mitochondrial with only a small proportion being peroxisomal. http://togogenome.org/gene/9685:CRYBB2 ^@ http://purl.uniprot.org/uniprot/M3WJG9 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:SUSD6 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULS7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SLC39A11 ^@ http://purl.uniprot.org/uniprot/A0A337RYN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UD99|||http://purl.uniprot.org/uniprot/A0A2I2UQQ6|||http://purl.uniprot.org/uniprot/M3VVD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9685:NECAP1 ^@ http://purl.uniprot.org/uniprot/M3VYB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9685:FARSA ^@ http://purl.uniprot.org/uniprot/A0A337SST7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/9685:RTCB ^@ http://purl.uniprot.org/uniprot/M3XE87 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/9685:KCNK5 ^@ http://purl.uniprot.org/uniprot/M3XCY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9685:WDR35 ^@ http://purl.uniprot.org/uniprot/A0A2I2UE42|||http://purl.uniprot.org/uniprot/A0A2I2V4H6 ^@ Function|||Subcellular Location Annotation ^@ As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.|||centrosome|||cilium basal body http://togogenome.org/gene/9685:HSD17B12 ^@ http://purl.uniprot.org/uniprot/M3XF85 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:CNN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V051 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9685:PYCARD ^@ http://purl.uniprot.org/uniprot/A0A337STP2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Inflammasome http://togogenome.org/gene/9685:YDJC ^@ http://purl.uniprot.org/uniprot/M3W8T1 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/9685:SERPINI1 ^@ http://purl.uniprot.org/uniprot/M3W7B6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:IL13RA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GABRB1 ^@ http://purl.uniprot.org/uniprot/M3W754 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:PLAU ^@ http://purl.uniprot.org/uniprot/M3WMV1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:INSL6 ^@ http://purl.uniprot.org/uniprot/M3X1G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||May have a role in sperm development and fertilization.|||Secreted http://togogenome.org/gene/9685:ARL5A ^@ http://purl.uniprot.org/uniprot/M3WL92 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9685:METAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQQ9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. http://togogenome.org/gene/9685:LOC101100387 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y107|||http://purl.uniprot.org/uniprot/M3X5G2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9685:TAS2R38 ^@ http://purl.uniprot.org/uniprot/M3X5D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9685:LOC105260541 ^@ http://purl.uniprot.org/uniprot/M3XAW8 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:PAX7 ^@ http://purl.uniprot.org/uniprot/A0A337SMJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9685:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/M3WUI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9685:GSDME ^@ http://purl.uniprot.org/uniprot/M3WLI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:DAZL ^@ http://purl.uniprot.org/uniprot/A0A337SR91 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:NPL ^@ http://purl.uniprot.org/uniprot/A0A337S5Y4|||http://purl.uniprot.org/uniprot/M3WR24 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family. NanA subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9685:SCN4A ^@ http://purl.uniprot.org/uniprot/M3W0G7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9685:STAT3 ^@ http://purl.uniprot.org/uniprot/M3VY01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:FTH1 ^@ http://purl.uniprot.org/uniprot/Q2MHN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ferritin family.|||Cytoplasm|||Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.|||Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). http://togogenome.org/gene/9685:TENM1 ^@ http://purl.uniprot.org/uniprot/M3W9F8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:PRF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKT0|||http://purl.uniprot.org/uniprot/A7LLU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/9685:CGAS ^@ http://purl.uniprot.org/uniprot/A0A337SIS0 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9685:LOC101095121 ^@ http://purl.uniprot.org/uniprot/M3WD92 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:SERPINB13 ^@ http://purl.uniprot.org/uniprot/A0A337S8U3|||http://purl.uniprot.org/uniprot/A0A337SB03 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:PNPLA1 ^@ http://purl.uniprot.org/uniprot/M3VX77 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LOC101089195 ^@ http://purl.uniprot.org/uniprot/A0A337S9P4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SMUG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U349 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/9685:TASP1 ^@ http://purl.uniprot.org/uniprot/A0A337SL99 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9685:MTRF1L ^@ http://purl.uniprot.org/uniprot/A0A2I2U1A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9685:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAY0|||http://purl.uniprot.org/uniprot/M3VWS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:KCNK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGN8|||http://purl.uniprot.org/uniprot/M3WVE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9685:SDC1 ^@ http://purl.uniprot.org/uniprot/M3W3X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9685:ITIH1 ^@ http://purl.uniprot.org/uniprot/M3WN59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9685:STOML2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULA7 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9685:TUBA8 ^@ http://purl.uniprot.org/uniprot/M3WCF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9685:WDR44 ^@ http://purl.uniprot.org/uniprot/M3W8K9 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9685:TM2D2 ^@ http://purl.uniprot.org/uniprot/M3VYT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ART5 ^@ http://purl.uniprot.org/uniprot/M3X2S2 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9685:NIPSNAP1 ^@ http://purl.uniprot.org/uniprot/M3W1U8 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9685:ANXA10 ^@ http://purl.uniprot.org/uniprot/M3W3I3 ^@ Similarity ^@ Belongs to the annexin family. http://togogenome.org/gene/9685:CNOT8 ^@ http://purl.uniprot.org/uniprot/M3VV25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9685:LSM6 ^@ http://purl.uniprot.org/uniprot/M3VZM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9685:KAT5 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9A3|||http://purl.uniprot.org/uniprot/M3VTZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9685:TM4SF4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9685:CRYAA ^@ http://purl.uniprot.org/uniprot/P68282 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-70 may increase chaperone activity.|||Belongs to the small heat shock protein (HSP20) family.|||Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.|||Cytoplasm|||Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA (By similarity).|||Nucleus|||Undergoes age-dependent proteolytical cleavage at the C-terminus. http://togogenome.org/gene/9685:B3GALT4 ^@ http://purl.uniprot.org/uniprot/M3W1E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:PADI6 ^@ http://purl.uniprot.org/uniprot/A1A438 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9685:RNASEH1 ^@ http://purl.uniprot.org/uniprot/M3WVC8 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/9685:CPA6 ^@ http://purl.uniprot.org/uniprot/M3W7E0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9685:LOC101080977 ^@ http://purl.uniprot.org/uniprot/A0A5F5XN46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9685:STT3A ^@ http://purl.uniprot.org/uniprot/M3WLY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9685:MVP ^@ http://purl.uniprot.org/uniprot/Q18PA2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. http://togogenome.org/gene/9685:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/M3X0C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/9685:BBOX1 ^@ http://purl.uniprot.org/uniprot/M3WKZ6 ^@ Function|||Similarity ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine. http://togogenome.org/gene/9685:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9W7|||http://purl.uniprot.org/uniprot/A0A337S6M9|||http://purl.uniprot.org/uniprot/A0A337SJH0 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9685:A2M ^@ http://purl.uniprot.org/uniprot/M3WMA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9685:LOC105261264 ^@ http://purl.uniprot.org/uniprot/M3WHR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9685:DHODH ^@ http://purl.uniprot.org/uniprot/M3WTW7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101091557 ^@ http://purl.uniprot.org/uniprot/A0A337SUV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:RPS12 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1K1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9685:ONECUT1 ^@ http://purl.uniprot.org/uniprot/M3W213 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9685:BRCA2 ^@ http://purl.uniprot.org/uniprot/Q864S8 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity).|||Monomer and dimer. Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair. Interacts with SEM1, WDR16, USP11, DMC1, ROCK2 and NPM1. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Component of the homologous recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2, DSS1 and RAD51 (By similarity). Within the complex, interacts with ERCC5/XPG and PALB2 (By similarity). Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with POLH; the interaction is direct. Interacts with the TREX-2 complex subunits PCID2 and SEM1 (By similarity). Interacts with HSF2BP and BRME1; the interaction with HSF2BP is direct and allows the formation of a ternary complex. The complex BRME1:HSF2BP:BRCA2 interacts with SPATA22, MEIOB and RAD51 (By similarity).|||Nucleus|||Phosphorylated by ATM upon irradiation-induced DNA damage. Phosphorylation by CHEK1 and CHEK2 regulates interaction with RAD51. Phosphorylation at Ser-3236 by CDK1 and CDK2 is low in S phase when recombination is active, but increases as cells progress towards mitosis; this phosphorylation prevents homologous recombination-dependent repair during S phase and G2 by inhibiting RAD51 binding.|||Ubiquitinated in the absence of DNA damage; this does not lead to proteasomal degradation. In contrast, ubiquitination in response to DNA damage leads to proteasomal degradation.|||centrosome http://togogenome.org/gene/9685:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V317|||http://purl.uniprot.org/uniprot/A0A2I2V3W2|||http://purl.uniprot.org/uniprot/M3WPI1 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9685:GATA2 ^@ http://purl.uniprot.org/uniprot/M3W5E4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CHST8 ^@ http://purl.uniprot.org/uniprot/M3XD93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:TADA3 ^@ http://purl.uniprot.org/uniprot/M3WK95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9685:LOC101082234 ^@ http://purl.uniprot.org/uniprot/M3XAR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:RPS6 ^@ http://purl.uniprot.org/uniprot/M3VYQ2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/9685:SNAP47 ^@ http://purl.uniprot.org/uniprot/M3WMY2 ^@ Similarity ^@ Belongs to the SVAP1 family. http://togogenome.org/gene/9685:ATP5MF ^@ http://purl.uniprot.org/uniprot/A0A5F5XP54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:CDIPT ^@ http://purl.uniprot.org/uniprot/M3WK64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9685:LOC101083921 ^@ http://purl.uniprot.org/uniprot/M3WSM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/M3VYC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9685:FAM98A ^@ http://purl.uniprot.org/uniprot/M3WUT2 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9685:GLRA4 ^@ http://purl.uniprot.org/uniprot/M3WF44 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9685:INTS8 ^@ http://purl.uniprot.org/uniprot/M3W5A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/9685:PODXL ^@ http://purl.uniprot.org/uniprot/A0A5F5XE19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the podocalyxin family.|||Cell membrane|||Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.|||Membrane|||Membrane raft|||filopodium|||lamellipodium|||microvillus|||ruffle http://togogenome.org/gene/9685:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A5F5XWD6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:NEFL ^@ http://purl.uniprot.org/uniprot/A0A337SJ89 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:LOC101094108 ^@ http://purl.uniprot.org/uniprot/A0A2I2U006 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/9685:WWOX ^@ http://purl.uniprot.org/uniprot/M3WHL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Golgi apparatus|||Lysosome|||Mitochondrion http://togogenome.org/gene/9685:ERBB3 ^@ http://purl.uniprot.org/uniprot/M3WLH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9685:FBLN5 ^@ http://purl.uniprot.org/uniprot/M3WFS9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:JPT1 ^@ http://purl.uniprot.org/uniprot/M3WKU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:LOC101098824 ^@ http://purl.uniprot.org/uniprot/M3XAB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PHACTR4 ^@ http://purl.uniprot.org/uniprot/M3WIT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:FAM32A ^@ http://purl.uniprot.org/uniprot/A0A2I2V5E8 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/9685:SEC61B ^@ http://purl.uniprot.org/uniprot/M3WGK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/9685:ACTR6 ^@ http://purl.uniprot.org/uniprot/A0A337STW7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:SYBU ^@ http://purl.uniprot.org/uniprot/M3XCK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:HSDL2 ^@ http://purl.uniprot.org/uniprot/M3WKK8 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9685:LOC101088996 ^@ http://purl.uniprot.org/uniprot/O19434 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9685:UNK ^@ http://purl.uniprot.org/uniprot/A0A5F5XPP6|||http://purl.uniprot.org/uniprot/M3W4M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/9685:RNF7 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1X7 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9685:LOC101099751 ^@ http://purl.uniprot.org/uniprot/M3WSB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DHRS3 ^@ http://purl.uniprot.org/uniprot/M3VV13 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:FBXO32 ^@ http://purl.uniprot.org/uniprot/M3WDB6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ACADSB ^@ http://purl.uniprot.org/uniprot/M3W0B5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9685:CCKAR ^@ http://purl.uniprot.org/uniprot/M3W880 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9685:LOC101100152 ^@ http://purl.uniprot.org/uniprot/M3WVE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LRRC8A ^@ http://purl.uniprot.org/uniprot/M3W4V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:FAS ^@ http://purl.uniprot.org/uniprot/Q861W6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/9685:LOC102900869 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4A5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9685:DGUOK ^@ http://purl.uniprot.org/uniprot/A0A337SML0 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9685:KIF20A ^@ http://purl.uniprot.org/uniprot/M3VX50 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:EEF1B2 ^@ http://purl.uniprot.org/uniprot/M3WCX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/9685:PCMTD1 ^@ http://purl.uniprot.org/uniprot/M3VW62 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9685:ADAM10 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWI1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A2I2UR49 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9685:ERBB2 ^@ http://purl.uniprot.org/uniprot/Q49LT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9685:MS4A1 ^@ http://purl.uniprot.org/uniprot/Q5R1M8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9685:FAM167B ^@ http://purl.uniprot.org/uniprot/M3WH16 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9685:RPL6 ^@ http://purl.uniprot.org/uniprot/M3W6M1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9685:TMEM39A ^@ http://purl.uniprot.org/uniprot/M3XFQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9685:PEG3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V165 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PRTFDC1 ^@ http://purl.uniprot.org/uniprot/M3VV03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9685:FLA-I ^@ http://purl.uniprot.org/uniprot/Q30493 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9685:ZFYVE9 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5L6|||http://purl.uniprot.org/uniprot/M3XFS0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/9685:CSE1L ^@ http://purl.uniprot.org/uniprot/M3VWN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/9685:CNP ^@ http://purl.uniprot.org/uniprot/M3WWG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.|||Melanosome|||Membrane http://togogenome.org/gene/9685:ACTL6B ^@ http://purl.uniprot.org/uniprot/M3W6L2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:NDUFB3 ^@ http://purl.uniprot.org/uniprot/M3X4G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:FOXJ1 ^@ http://purl.uniprot.org/uniprot/M3W4P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FOXJ1 family.|||Nucleus http://togogenome.org/gene/9685:OTUB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUR0 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9685:JAK2 ^@ http://purl.uniprot.org/uniprot/A0A337SI69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Endomembrane system|||Nucleus http://togogenome.org/gene/9685:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A2I2U759|||http://purl.uniprot.org/uniprot/A0A2I2U771|||http://purl.uniprot.org/uniprot/A0A337S7H6|||http://purl.uniprot.org/uniprot/A0A337SUN6 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9685:DLK2 ^@ http://purl.uniprot.org/uniprot/M3X710 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:PATL1 ^@ http://purl.uniprot.org/uniprot/M3WMV5 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9685:CLGN ^@ http://purl.uniprot.org/uniprot/A0A2I2UKH3 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9685:TYW3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U834 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9685:LOC101099681 ^@ http://purl.uniprot.org/uniprot/M3X1Q1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:RABGGTB ^@ http://purl.uniprot.org/uniprot/A0A2I2UUA5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9685:GRPEL1 ^@ http://purl.uniprot.org/uniprot/M3X6X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9685:AGER ^@ http://purl.uniprot.org/uniprot/M3W2C8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:AMOT ^@ http://purl.uniprot.org/uniprot/M3WH21 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9685:GPR17 ^@ http://purl.uniprot.org/uniprot/M3WIC9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:DUS3L ^@ http://purl.uniprot.org/uniprot/M3X9U8 ^@ Similarity ^@ Belongs to the dus family. Dus3 subfamily. http://togogenome.org/gene/9685:LOC101101385 ^@ http://purl.uniprot.org/uniprot/M3X7Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MTERF1 ^@ http://purl.uniprot.org/uniprot/A0A337RW51 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9685:LOC101089643 ^@ http://purl.uniprot.org/uniprot/M3WMD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:RPL10 ^@ http://purl.uniprot.org/uniprot/M3WF14 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9685:PSME2 ^@ http://purl.uniprot.org/uniprot/A0A337STN2 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9685:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQC1|||http://purl.uniprot.org/uniprot/A0A337S444 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9685:PDC ^@ http://purl.uniprot.org/uniprot/P41686 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosducin family.|||Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.|||Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.|||Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.|||Nucleus|||Photoreceptor inner segment|||cytosol|||photoreceptor outer segment http://togogenome.org/gene/9685:ELOVL5 ^@ http://purl.uniprot.org/uniprot/M3VV18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||dendrite http://togogenome.org/gene/9685:AASDH ^@ http://purl.uniprot.org/uniprot/A0A2I2UUF5|||http://purl.uniprot.org/uniprot/M3W654 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:DRC7 ^@ http://purl.uniprot.org/uniprot/M3W8B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC7 family.|||cilium axoneme|||flagellum|||flagellum axoneme http://togogenome.org/gene/9685:TMEM91 ^@ http://purl.uniprot.org/uniprot/M3WTE0 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9685:CLDN7 ^@ http://purl.uniprot.org/uniprot/M3WXP4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:DCAF13 ^@ http://purl.uniprot.org/uniprot/M3WYT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/9685:SCML2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XT92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9685:AP4B1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUU9|||http://purl.uniprot.org/uniprot/A0A2I2V1N6 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9685:MFAP2 ^@ http://purl.uniprot.org/uniprot/M3WVF4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9685:NDUFC2 ^@ http://purl.uniprot.org/uniprot/M3XBJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:FBXO9 ^@ http://purl.uniprot.org/uniprot/M3WWA9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9685:KATNAL2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XNK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9685:AK4 ^@ http://purl.uniprot.org/uniprot/A0A5F5XDY9 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/9685:DHX58 ^@ http://purl.uniprot.org/uniprot/M3VXZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9685:MYO7A ^@ http://purl.uniprot.org/uniprot/A0A2I2U0R3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9685:CD3E ^@ http://purl.uniprot.org/uniprot/Q5R1Q1 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.|||Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1. Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation. http://togogenome.org/gene/9685:AHCY ^@ http://purl.uniprot.org/uniprot/A0A2I2U551 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9685:KCNJ13 ^@ http://purl.uniprot.org/uniprot/A0A5F5XK79|||http://purl.uniprot.org/uniprot/M3VZI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9685:S100PBP ^@ http://purl.uniprot.org/uniprot/M3W0L2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:INIP ^@ http://purl.uniprot.org/uniprot/A0A2I2V4C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/9685:TOB1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XD56 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9685:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A2I2U088|||http://purl.uniprot.org/uniprot/M3WD42 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:DCN ^@ http://purl.uniprot.org/uniprot/M3X0W2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/9685:CFAP126 ^@ http://purl.uniprot.org/uniprot/M3WN90 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9685:MED4 ^@ http://purl.uniprot.org/uniprot/M3WMD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:UGDH ^@ http://purl.uniprot.org/uniprot/M3WBQ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/9685:PGM3 ^@ http://purl.uniprot.org/uniprot/M3W4K3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/9685:CAPN11 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7E5 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9685:GPN1 ^@ http://purl.uniprot.org/uniprot/M3WVZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9685:SLC9A9 ^@ http://purl.uniprot.org/uniprot/A0A5F5XFX9|||http://purl.uniprot.org/uniprot/A0A5F5XRV7|||http://purl.uniprot.org/uniprot/M3WB66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9685:CNGA4 ^@ http://purl.uniprot.org/uniprot/M3X858 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CASP7 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIV2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9685:ATP2A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U569|||http://purl.uniprot.org/uniprot/A0A2I2V2N1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9685:HARS1 ^@ http://purl.uniprot.org/uniprot/M3VWD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/9685:PDP2 ^@ http://purl.uniprot.org/uniprot/M3W5L0 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9685:LOC101095032 ^@ http://purl.uniprot.org/uniprot/A0A337SWK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101082692 ^@ http://purl.uniprot.org/uniprot/M3WSK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NSDHL ^@ http://purl.uniprot.org/uniprot/A0A2I2V0N8 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9685:TRMT1L ^@ http://purl.uniprot.org/uniprot/M3WET9 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||May play a role in motor coordination and exploratory behavior. http://togogenome.org/gene/9685:DAD1 ^@ http://purl.uniprot.org/uniprot/M3X9E1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9685:PDHA2 ^@ http://purl.uniprot.org/uniprot/M3W8H3 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/9685:CCNA2 ^@ http://purl.uniprot.org/uniprot/M3WZL5 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9685:FOXN2 ^@ http://purl.uniprot.org/uniprot/A0A337SWK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LAMB3 ^@ http://purl.uniprot.org/uniprot/M3WM02 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:MAP2K1 ^@ http://purl.uniprot.org/uniprot/M3X621 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:UCMA ^@ http://purl.uniprot.org/uniprot/A0A5F5XCV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/9685:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A337S3I6|||http://purl.uniprot.org/uniprot/M3X610 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9685:SDR16C5 ^@ http://purl.uniprot.org/uniprot/A0A5F5XXP7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:KCNA4 ^@ http://purl.uniprot.org/uniprot/M3XDS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.|||Cell membrane|||Membrane|||axon http://togogenome.org/gene/9685:PLPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTX4|||http://purl.uniprot.org/uniprot/M3X9V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9685:CLDN4 ^@ http://purl.uniprot.org/uniprot/M3W2R4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:KARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UD22|||http://purl.uniprot.org/uniprot/M3W9U6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:GALNT18 ^@ http://purl.uniprot.org/uniprot/M3VY51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:KEF43_p11 ^@ http://purl.uniprot.org/uniprot/P48888 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heme-copper respiratory oxidase family.|||Binds 2 heme A groups non-covalently per subunit.|||Binds a copper B center.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:PIAS1 ^@ http://purl.uniprot.org/uniprot/A0A337S3L4|||http://purl.uniprot.org/uniprot/M3WNG9 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9685:MRPL22 ^@ http://purl.uniprot.org/uniprot/A0A2I2USF6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9685:LDHC ^@ http://purl.uniprot.org/uniprot/A0A2I2U4Z0 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9685:STARD3NL ^@ http://purl.uniprot.org/uniprot/M3W9F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/9685:LOC101089797 ^@ http://purl.uniprot.org/uniprot/M3VYH2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CFTR ^@ http://purl.uniprot.org/uniprot/A0M8T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.|||Membrane|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.|||Recycling endosome membrane http://togogenome.org/gene/9685:TMEM205 ^@ http://purl.uniprot.org/uniprot/A0A337S1G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/9685:PHYHIP ^@ http://purl.uniprot.org/uniprot/M3WSE3 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9685:ARAP1 ^@ http://purl.uniprot.org/uniprot/A0A337SRE2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:TMEM106C ^@ http://purl.uniprot.org/uniprot/M3WJW5 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9685:PPP2R2A ^@ http://purl.uniprot.org/uniprot/A0A2I2UVM7 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9685:UNC119B ^@ http://purl.uniprot.org/uniprot/M3XB36 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9685:IP6K2 ^@ http://purl.uniprot.org/uniprot/M3WUD3 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9685:GLS2 ^@ http://purl.uniprot.org/uniprot/M3WG75 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9685:BCS1L ^@ http://purl.uniprot.org/uniprot/M3W1N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:PON3 ^@ http://purl.uniprot.org/uniprot/M3W9B9 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9685:DUSP9 ^@ http://purl.uniprot.org/uniprot/M3W1F9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9685:AP2A2 ^@ http://purl.uniprot.org/uniprot/M3WI80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).|||Belongs to the adaptor complexes large subunit family.|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.|||coated pit http://togogenome.org/gene/9685:TTC4 ^@ http://purl.uniprot.org/uniprot/M3XBQ5 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/9685:ADRA1A ^@ http://purl.uniprot.org/uniprot/A0A2I2U7I5|||http://purl.uniprot.org/uniprot/A0A2I2USK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9685:ZSCAN12 ^@ http://purl.uniprot.org/uniprot/M3XC63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/M3WYU8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9685:KRTAP11-1 ^@ http://purl.uniprot.org/uniprot/A0A337S0Q4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9685:NUP155 ^@ http://purl.uniprot.org/uniprot/M3WJN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/9685:FXYD7 ^@ http://purl.uniprot.org/uniprot/A0A337SRM9 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9685:GMNN ^@ http://purl.uniprot.org/uniprot/M3WRI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9685:PHACTR3 ^@ http://purl.uniprot.org/uniprot/A0A337S3B2 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9685:CCL19 ^@ http://purl.uniprot.org/uniprot/M3VZU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:CRABP2 ^@ http://purl.uniprot.org/uniprot/M3WZX3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9685:B3GALT1 ^@ http://purl.uniprot.org/uniprot/M3X7S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:LOC105260536 ^@ http://purl.uniprot.org/uniprot/M3X726 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:ERGIC3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXM4|||http://purl.uniprot.org/uniprot/M3VZZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9685:LYVE1 ^@ http://purl.uniprot.org/uniprot/M3VUP6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CCND1 ^@ http://purl.uniprot.org/uniprot/M3W9G0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:BTN1A1 ^@ http://purl.uniprot.org/uniprot/M3WR01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9685:F10 ^@ http://purl.uniprot.org/uniprot/M3WKC7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:CHMP1A ^@ http://purl.uniprot.org/uniprot/M3XFV1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9685:APOO ^@ http://purl.uniprot.org/uniprot/M3VTY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:ACTR1A ^@ http://purl.uniprot.org/uniprot/M3VWA6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:PHKB ^@ http://purl.uniprot.org/uniprot/A0A2I2URL9|||http://purl.uniprot.org/uniprot/A0A2I2UUF6|||http://purl.uniprot.org/uniprot/M3W9V0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/9685:SLC30A7 ^@ http://purl.uniprot.org/uniprot/M3WED5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9685:CB4H12orf57 ^@ http://purl.uniprot.org/uniprot/M3W1X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/9685:ACVR1 ^@ http://purl.uniprot.org/uniprot/M3W8V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9685:EXOSC1 ^@ http://purl.uniprot.org/uniprot/A0A337S7M7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:ALDOC ^@ http://purl.uniprot.org/uniprot/A0A2I2V3I1 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9685:TMEM170A ^@ http://purl.uniprot.org/uniprot/A0A337S8C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9685:UNC5C ^@ http://purl.uniprot.org/uniprot/A0A2I2UWZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9685:NR1I3 ^@ http://purl.uniprot.org/uniprot/M3VUV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9685:RABEP2 ^@ http://purl.uniprot.org/uniprot/A0A337SCI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Cytoplasm|||Early endosome|||Endosome http://togogenome.org/gene/9685:ISCU ^@ http://purl.uniprot.org/uniprot/A0A2I2USP2 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. http://togogenome.org/gene/9685:GALNT13 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:PALMD ^@ http://purl.uniprot.org/uniprot/M3VVU7 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9685:ZDHHC24 ^@ http://purl.uniprot.org/uniprot/M3XCJ0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:LOC101096317 ^@ http://purl.uniprot.org/uniprot/M3W3Q0 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9685:USH1G ^@ http://purl.uniprot.org/uniprot/M3XG41 ^@ Function ^@ Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9685:PAF1 ^@ http://purl.uniprot.org/uniprot/M3WDU4 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/9685:SPSB4 ^@ http://purl.uniprot.org/uniprot/M3WXV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9685:VAX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LIN28A ^@ http://purl.uniprot.org/uniprot/D3U660 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9685:SERPINE1 ^@ http://purl.uniprot.org/uniprot/M3W4Q4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:KCNV1 ^@ http://purl.uniprot.org/uniprot/M3XBU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/9685:GRM8 ^@ http://purl.uniprot.org/uniprot/A0A5K1UJJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LETMD1 ^@ http://purl.uniprot.org/uniprot/A0A337SF57 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/M3WDR7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:CPLX4 ^@ http://purl.uniprot.org/uniprot/M3W612 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9685:TXNRD1 ^@ http://purl.uniprot.org/uniprot/M3W0Q4 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/9685:SERINC5 ^@ http://purl.uniprot.org/uniprot/M3W150 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9685:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUQ5|||http://purl.uniprot.org/uniprot/M3WFN1 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/9685:RGR ^@ http://purl.uniprot.org/uniprot/M3VX16 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PARD6A ^@ http://purl.uniprot.org/uniprot/M3WB52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9685:MTERF2 ^@ http://purl.uniprot.org/uniprot/M3WY64 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9685:CNTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQD8|||http://purl.uniprot.org/uniprot/M3X487 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9685:GNA13 ^@ http://purl.uniprot.org/uniprot/M3X9G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/9685:MED8 ^@ http://purl.uniprot.org/uniprot/M3WLZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:IL1R2 ^@ http://purl.uniprot.org/uniprot/M3WGF0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:MAGI2 ^@ http://purl.uniprot.org/uniprot/M3WXB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CKAP5 ^@ http://purl.uniprot.org/uniprot/M3X2R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOG/XMAP215 family.|||kinetochore http://togogenome.org/gene/9685:PANX1 ^@ http://purl.uniprot.org/uniprot/M3W287 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||S-nitrosylation inhibits channel currents and ATP release.|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9685:RGS3 ^@ http://purl.uniprot.org/uniprot/M3WX81 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:GLYAT ^@ http://purl.uniprot.org/uniprot/M3WPY7 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9685:STIM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UY42|||http://purl.uniprot.org/uniprot/A0A337SAK7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:CLK3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UMG1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:EFNA1 ^@ http://purl.uniprot.org/uniprot/M3X089 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:ENTPD7 ^@ http://purl.uniprot.org/uniprot/M3WKL5 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9685:SLC46A2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XFZ8|||http://purl.uniprot.org/uniprot/M3WTC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RXRG ^@ http://purl.uniprot.org/uniprot/M3WDW0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9685:LOC101095042 ^@ http://purl.uniprot.org/uniprot/M3XB96 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TSHB ^@ http://purl.uniprot.org/uniprot/Q52R90 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|||Indispensable for the control of thyroid structure and metabolism.|||Secreted http://togogenome.org/gene/9685:FAM214B ^@ http://purl.uniprot.org/uniprot/A0A337S286 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus http://togogenome.org/gene/9685:TSEN54 ^@ http://purl.uniprot.org/uniprot/M3XA93 ^@ Similarity ^@ Belongs to the SEN54 family. http://togogenome.org/gene/9685:TSPAN32 ^@ http://purl.uniprot.org/uniprot/M3W6S7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:SMIM7 ^@ http://purl.uniprot.org/uniprot/A0A337SU07 ^@ Similarity ^@ Belongs to the SMIM7 family. http://togogenome.org/gene/9685:CAMK1 ^@ http://purl.uniprot.org/uniprot/M3WK93 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:SERPINC1 ^@ http://purl.uniprot.org/uniprot/M3WLL8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/9685:LOC105261153 ^@ http://purl.uniprot.org/uniprot/M3WDH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||myofibril http://togogenome.org/gene/9685:SLC1A6 ^@ http://purl.uniprot.org/uniprot/M3W7T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9685:SMC4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Chromosome|||Nucleus http://togogenome.org/gene/9685:ING2 ^@ http://purl.uniprot.org/uniprot/M3WYK9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9685:LSM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2US81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9685:PTX4 ^@ http://purl.uniprot.org/uniprot/A0A337SS86 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:DDRGK1 ^@ http://purl.uniprot.org/uniprot/M3X2B8 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/9685:RPS3A ^@ http://purl.uniprot.org/uniprot/A0A0A0MQ24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus|||nucleolus http://togogenome.org/gene/9685:KCTD13 ^@ http://purl.uniprot.org/uniprot/M3XGC5 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9685:LOC101095131 ^@ http://purl.uniprot.org/uniprot/M3X6H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MTHFD1 ^@ http://purl.uniprot.org/uniprot/M3W8F9 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/9685:LOC100533977 ^@ http://purl.uniprot.org/uniprot/E5D2Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9685:ARL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9685:LYRM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNX2 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9685:FGR ^@ http://purl.uniprot.org/uniprot/M3W8J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9685:GLI1 ^@ http://purl.uniprot.org/uniprot/M3VXV2 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9685:SEC63 ^@ http://purl.uniprot.org/uniprot/M3VY59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:EIF4EBP3 ^@ http://purl.uniprot.org/uniprot/A0A337SDV7 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9685:LOC101084205 ^@ http://purl.uniprot.org/uniprot/A0A337S4Y2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LOC101082677 ^@ http://purl.uniprot.org/uniprot/M3X918 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9685:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A337SFB7 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9685:ARID5B ^@ http://purl.uniprot.org/uniprot/A0A2I2U4D2|||http://purl.uniprot.org/uniprot/A0A337SR71 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/9685:CSTF1 ^@ http://purl.uniprot.org/uniprot/M3X8P0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PSMA1 ^@ http://purl.uniprot.org/uniprot/M3WF05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9685:TSPAN4 ^@ http://purl.uniprot.org/uniprot/A0A337SDZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:IL5 ^@ http://purl.uniprot.org/uniprot/O77515 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).|||Secreted http://togogenome.org/gene/9685:BRINP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4R9 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9685:INSIG2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XQY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9685:SLC35B4 ^@ http://purl.uniprot.org/uniprot/M3WHT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9685:OTP ^@ http://purl.uniprot.org/uniprot/A0A2I2UY03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:DHCR7 ^@ http://purl.uniprot.org/uniprot/M3W1L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9685:KIFBP ^@ http://purl.uniprot.org/uniprot/A0A337SXN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/9685:ASB8 ^@ http://purl.uniprot.org/uniprot/A0A2I2UI44 ^@ Function ^@ May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9685:GPR108 ^@ http://purl.uniprot.org/uniprot/A0A5F5XJ50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TFAP2D ^@ http://purl.uniprot.org/uniprot/M3W0C3 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9685:STAMBPL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4S8 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9685:APEX2 ^@ http://purl.uniprot.org/uniprot/M3X3R1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9685:LOC101084373 ^@ http://purl.uniprot.org/uniprot/M3WY87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101082667 ^@ http://purl.uniprot.org/uniprot/A0A5F5XDY1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/9685:PAH ^@ http://purl.uniprot.org/uniprot/A0A337S7G7 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9685:GPHB5 ^@ http://purl.uniprot.org/uniprot/M3XD03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9685:RNF4 ^@ http://purl.uniprot.org/uniprot/M3W1H1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101080702 ^@ http://purl.uniprot.org/uniprot/M3X874 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CCT7 ^@ http://purl.uniprot.org/uniprot/M3WJC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/9685:EEF1A1 ^@ http://purl.uniprot.org/uniprot/Q66RN5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cell membrane|||Cytoplasm|||Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1 and TXK. Interacts with KARS1. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner (By similarity). Interacts with PPP1R16B (By similarity). Interacts with SPHK1 and SPHK2; both interactions increase SPHK1 and SPHK2 kinase activity (By similarity).|||ISGylated.|||Nucleus|||Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2. Phosphorylation by TGFBR1 inhibits translation elongation.|||Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.|||Trimethylated at Lys-79 by EEF1AKMT1. Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Trimethylated at Lys-318 by EEF1AKMT2. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at Gly-2 by METTL13. Mono- and dimethylated at Lys-55 by METTL13; dimethylated form is predominant.|||Ubiquitinated at Lys-385 by RNF14 in response to ribosome collisions (ribosome stalling), leading to its degradation by the proteasome and rescue of stalled ribosomes.|||nucleolus http://togogenome.org/gene/9685:HOXA1 ^@ http://purl.uniprot.org/uniprot/M3W8N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9685:LYRM4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCY4 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9685:MAPK14 ^@ http://purl.uniprot.org/uniprot/M3X6W3|||http://purl.uniprot.org/uniprot/M3XAW7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9685:CFI ^@ http://purl.uniprot.org/uniprot/A0A2I2U350 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:RGS7BP ^@ http://purl.uniprot.org/uniprot/A0A2I2UVK5 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9685:USP9X ^@ http://purl.uniprot.org/uniprot/A0A2I2U2V7 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9685:MTF2 ^@ http://purl.uniprot.org/uniprot/M3WLT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9685:EDEM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UR70|||http://purl.uniprot.org/uniprot/A0A337RZR6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9685:LOC768284 ^@ http://purl.uniprot.org/uniprot/M3X1P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9685:FARSB ^@ http://purl.uniprot.org/uniprot/M3X0C2 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/9685:OSBPL1A ^@ http://purl.uniprot.org/uniprot/A0A5F5XTE9 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9685:C8A ^@ http://purl.uniprot.org/uniprot/M3W158 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:POLR2I ^@ http://purl.uniprot.org/uniprot/M3X8K0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9685:TAAR9 ^@ http://purl.uniprot.org/uniprot/M3WV25 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:AQP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:MPPED2 ^@ http://purl.uniprot.org/uniprot/M3VX47 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9685:AHSA1 ^@ http://purl.uniprot.org/uniprot/M3VX03 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9685:MFSD5 ^@ http://purl.uniprot.org/uniprot/M3W4V7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Cell membrane|||Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.|||Membrane http://togogenome.org/gene/9685:IL23A ^@ http://purl.uniprot.org/uniprot/M3WG71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9685:LOC105260540 ^@ http://purl.uniprot.org/uniprot/M3X726 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:LETM2 ^@ http://purl.uniprot.org/uniprot/M3WJ60 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A337SPA9|||http://purl.uniprot.org/uniprot/M3WC77 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:BAK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUV3 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9685:STOML3 ^@ http://purl.uniprot.org/uniprot/A0A337S9V5 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9685:SH3PXD2A ^@ http://purl.uniprot.org/uniprot/A0A2I2ULS4|||http://purl.uniprot.org/uniprot/M3VYF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm http://togogenome.org/gene/9685:CSTF3 ^@ http://purl.uniprot.org/uniprot/M3WPX4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ZHX2 ^@ http://purl.uniprot.org/uniprot/M3WR26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9685:TSR1 ^@ http://purl.uniprot.org/uniprot/M3W5N8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9685:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A2I2U4E2|||http://purl.uniprot.org/uniprot/A0A337S3E7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9685:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V496 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:B4GAT1 ^@ http://purl.uniprot.org/uniprot/M3WQ57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:BZW2 ^@ http://purl.uniprot.org/uniprot/M3WAT8 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9685:BNIP1 ^@ http://purl.uniprot.org/uniprot/A0A337SNU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:NUP107 ^@ http://purl.uniprot.org/uniprot/M3WHP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9685:LOC109494884 ^@ http://purl.uniprot.org/uniprot/M3WA03 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9685:NUCB2 ^@ http://purl.uniprot.org/uniprot/M3W7H2 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9685:RABAC1 ^@ http://purl.uniprot.org/uniprot/M3X0S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9685:LAMB1 ^@ http://purl.uniprot.org/uniprot/M3W292 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9685:MAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEF9|||http://purl.uniprot.org/uniprot/M3XEW5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:NIT1 ^@ http://purl.uniprot.org/uniprot/A0A337SSX6 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/9685:HOATZ ^@ http://purl.uniprot.org/uniprot/A0A337STH5 ^@ Similarity ^@ Belongs to the HOATZ family. http://togogenome.org/gene/9685:CSGALNACT2 ^@ http://purl.uniprot.org/uniprot/M3WJU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9685:CTSB ^@ http://purl.uniprot.org/uniprot/M3WLU0 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9685:FOXP2 ^@ http://purl.uniprot.org/uniprot/A9UCM4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TSHZ2 ^@ http://purl.uniprot.org/uniprot/M3WL06 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/9685:ERBB4 ^@ http://purl.uniprot.org/uniprot/A0A337S8Z7|||http://purl.uniprot.org/uniprot/A0A337SET3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9685:GLRX ^@ http://purl.uniprot.org/uniprot/M3X3M9 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9685:DDX27 ^@ http://purl.uniprot.org/uniprot/M3VWN4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9685:NDUFA11 ^@ http://purl.uniprot.org/uniprot/M3WND4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA11 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101087880 ^@ http://purl.uniprot.org/uniprot/M3VX87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9685:MS4A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGY8|||http://purl.uniprot.org/uniprot/A0A337SUC4 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9685:ZNF397 ^@ http://purl.uniprot.org/uniprot/M3XG48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:F12 ^@ http://purl.uniprot.org/uniprot/D0F0C7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:LOC101095449 ^@ http://purl.uniprot.org/uniprot/M3X457 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UP96|||http://purl.uniprot.org/uniprot/M3W369 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:LOC101091589 ^@ http://purl.uniprot.org/uniprot/M3X8A5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ITGA8 ^@ http://purl.uniprot.org/uniprot/M3VY58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9685:GTF2F2 ^@ http://purl.uniprot.org/uniprot/M3VXW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. http://togogenome.org/gene/9685:LOC101101588 ^@ http://purl.uniprot.org/uniprot/M3W476 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SARM1 ^@ http://purl.uniprot.org/uniprot/M3W9I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SARM1 family.|||axon http://togogenome.org/gene/9685:TSHR ^@ http://purl.uniprot.org/uniprot/A0A2I2U839|||http://purl.uniprot.org/uniprot/A0A2I2ULI7|||http://purl.uniprot.org/uniprot/A0A2I2UW04|||http://purl.uniprot.org/uniprot/A0A2I2V0E6|||http://purl.uniprot.org/uniprot/Q9BGN4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Glycosylated.|||Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.|||Lateral cell membrane|||Membrane|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.|||Sulfated. Sulfation on Tyr-384 plays a role in thyrotropin receptor binding and activation. http://togogenome.org/gene/9685:ACTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNZ9|||http://purl.uniprot.org/uniprot/A0A2I2V4J9|||http://purl.uniprot.org/uniprot/A0A5F5XDQ3|||http://purl.uniprot.org/uniprot/M3VVH8 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9685:IFNB1 ^@ http://purl.uniprot.org/uniprot/A1YQW1|||http://purl.uniprot.org/uniprot/Q9N2J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha/beta interferon family.|||Monomer.|||Secreted|||Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity). http://togogenome.org/gene/9685:LY75 ^@ http://purl.uniprot.org/uniprot/M3W724 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:YAE1 ^@ http://purl.uniprot.org/uniprot/M3X5T8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:STPG1 ^@ http://purl.uniprot.org/uniprot/M3VXU1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:PARP14 ^@ http://purl.uniprot.org/uniprot/M3XBX0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9685:LOC101085573 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZE0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9685:SS18L2 ^@ http://purl.uniprot.org/uniprot/M3VZU8 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9685:SAR1A ^@ http://purl.uniprot.org/uniprot/M3X5G3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9685:TRMT11 ^@ http://purl.uniprot.org/uniprot/M3WUD1 ^@ Function|||Subunit ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.|||Interacts with TRMT112. http://togogenome.org/gene/9685:TMBIM6 ^@ http://purl.uniprot.org/uniprot/M3WBG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9685:TBX6 ^@ http://purl.uniprot.org/uniprot/A0A337SF13 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9685:NNAT ^@ http://purl.uniprot.org/uniprot/A0A2I2ULK2 ^@ Similarity ^@ Belongs to the neuronatin family. http://togogenome.org/gene/9685:ABHD1 ^@ http://purl.uniprot.org/uniprot/M3W3J8 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9685:TPPP3 ^@ http://purl.uniprot.org/uniprot/M3WB48 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9685:CD1H11orf58 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9P8 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/9685:SEPTIN9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBG2 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9685:PPIA ^@ http://purl.uniprot.org/uniprot/G3XEW5|||http://purl.uniprot.org/uniprot/Q8HXS3 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).|||Belongs to the cyclophilin-type PPIase family.|||Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.|||Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).|||Cytoplasm|||Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|||Secreted http://togogenome.org/gene/9685:FNBP1L ^@ http://purl.uniprot.org/uniprot/A0A337SI45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Cytoplasmic vesicle|||Membrane|||Vesicle|||cell cortex|||cytoskeleton http://togogenome.org/gene/9685:SPOP ^@ http://purl.uniprot.org/uniprot/A0A5F5Y0L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/9685:CAPN10 ^@ http://purl.uniprot.org/uniprot/M3WH08 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9685:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/M3W8X1 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9685:KCNMB1 ^@ http://purl.uniprot.org/uniprot/A0A337SSS1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9685:LOC101080738 ^@ http://purl.uniprot.org/uniprot/A0A5F5XE12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NBR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFK8 ^@ Subcellular Location Annotation ^@ Lysosome|||autophagosome http://togogenome.org/gene/9685:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVX8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9685:USP7 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPP8 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9685:PTPRN ^@ http://purl.uniprot.org/uniprot/M3WER6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9685:ARHGDIB ^@ http://purl.uniprot.org/uniprot/A0A2I2UL98 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9685:ADRB1 ^@ http://purl.uniprot.org/uniprot/Q9TST6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).|||Cell membrane|||Early endosome|||Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.|||Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4 (By similarity).|||The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor. http://togogenome.org/gene/9685:CRX ^@ http://purl.uniprot.org/uniprot/D3VZV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:FAM102B ^@ http://purl.uniprot.org/uniprot/M3X7D8 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9685:GTF2E1 ^@ http://purl.uniprot.org/uniprot/M3WU46 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/9685:DCTN5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/9685:TMEM144 ^@ http://purl.uniprot.org/uniprot/M3VY65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/9685:KEF43_p03 ^@ http://purl.uniprot.org/uniprot/P48921 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 5 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101091742 ^@ http://purl.uniprot.org/uniprot/M3WJE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:G6PC2 ^@ http://purl.uniprot.org/uniprot/M3W5B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:UFD1 ^@ http://purl.uniprot.org/uniprot/M3W1Y3 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/9685:CEP162 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8D2|||http://purl.uniprot.org/uniprot/A0A5F5Y1F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP162 family.|||centriole http://togogenome.org/gene/9685:ARL14 ^@ http://purl.uniprot.org/uniprot/M3W2M8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9685:HCRTR2 ^@ http://purl.uniprot.org/uniprot/M3X961 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SLC26A7 ^@ http://purl.uniprot.org/uniprot/M3WA61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9685:CHD8 ^@ http://purl.uniprot.org/uniprot/M3WJL6 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.|||DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.|||Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Sumoylated. http://togogenome.org/gene/9685:CHRND ^@ http://purl.uniprot.org/uniprot/M3W4H9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:ASPN ^@ http://purl.uniprot.org/uniprot/M3WWN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||extracellular matrix http://togogenome.org/gene/9685:PIWIL2 ^@ http://purl.uniprot.org/uniprot/M3WHZ7 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9685:MED27 ^@ http://purl.uniprot.org/uniprot/A0A337SIV1|||http://purl.uniprot.org/uniprot/A0A5F5XIS7|||http://purl.uniprot.org/uniprot/A0A5F5XTF9|||http://purl.uniprot.org/uniprot/M3W738 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 27 family.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:LOC101082634 ^@ http://purl.uniprot.org/uniprot/A0A2I2USQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TES ^@ http://purl.uniprot.org/uniprot/A0M8S5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).|||The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.|||focal adhesion http://togogenome.org/gene/9685:THRAP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UD94 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9685:PSMA2 ^@ http://purl.uniprot.org/uniprot/M3XAA2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9685:ADORA2A ^@ http://purl.uniprot.org/uniprot/M3X6N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9685:ACVR2B ^@ http://purl.uniprot.org/uniprot/A0A5F5XT25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9685:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/A0A337SK77 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:CDC5L ^@ http://purl.uniprot.org/uniprot/M3WBP2 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/9685:NEUROD4 ^@ http://purl.uniprot.org/uniprot/M3WIK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CPB2 ^@ http://purl.uniprot.org/uniprot/M3WAY1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9685:CCR2 ^@ http://purl.uniprot.org/uniprot/A5A4S2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:PNPLA7 ^@ http://purl.uniprot.org/uniprot/M3W0L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:CNOT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXJ2 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/9685:CYP1A1 ^@ http://purl.uniprot.org/uniprot/Q5KQT7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).|||Belongs to the cytochrome P450 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.|||Microsome membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A337RUZ9 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9685:PPM1G ^@ http://purl.uniprot.org/uniprot/M3WP20 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9685:TLR9 ^@ http://purl.uniprot.org/uniprot/Q5I2M7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.|||Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Endosome|||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).|||Lysosome|||Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with SMPDL3B (By similarity).|||phagosome http://togogenome.org/gene/9685:LDB2 ^@ http://purl.uniprot.org/uniprot/M3WCN7 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9685:LHFPL6 ^@ http://purl.uniprot.org/uniprot/A0A2I2V2K2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RC3H2 ^@ http://purl.uniprot.org/uniprot/A0A337S8A1 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/9685:THYN1 ^@ http://purl.uniprot.org/uniprot/M3W7P7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9685:GSTK1 ^@ http://purl.uniprot.org/uniprot/M3W7F3 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9685:RPS9 ^@ http://purl.uniprot.org/uniprot/M3WJZ7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9685:MORF4L2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XUU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:POP7 ^@ http://purl.uniprot.org/uniprot/M3W6L4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9685:LOC101101164 ^@ http://purl.uniprot.org/uniprot/M3WRL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SLC10A6 ^@ http://purl.uniprot.org/uniprot/M3XET2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9685:ETFA ^@ http://purl.uniprot.org/uniprot/M3W5A7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9685:LOC101084990 ^@ http://purl.uniprot.org/uniprot/M3X1U8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:COPB1 ^@ http://purl.uniprot.org/uniprot/M3WF04 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9685:TACC2 ^@ http://purl.uniprot.org/uniprot/M3X454 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/9685:MRPL1 ^@ http://purl.uniprot.org/uniprot/M3WJG1 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9685:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A337SDW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9685:LOC101089637 ^@ http://purl.uniprot.org/uniprot/M3WYZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A337S8V2|||http://purl.uniprot.org/uniprot/A0A337SLZ5|||http://purl.uniprot.org/uniprot/A0A337SQY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/9685:ALDH4A1 ^@ http://purl.uniprot.org/uniprot/A0A337SBS8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9685:PPM1N ^@ http://purl.uniprot.org/uniprot/M3XB35 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9685:SESN2 ^@ http://purl.uniprot.org/uniprot/M3WIS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9685:CC1H2orf88 ^@ http://purl.uniprot.org/uniprot/M3X8X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:IL18 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3U7|||http://purl.uniprot.org/uniprot/A2IRI7|||http://purl.uniprot.org/uniprot/Q95M33 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form. http://togogenome.org/gene/9685:EIF2A ^@ http://purl.uniprot.org/uniprot/M3WEX5 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/9685:CHMP4C ^@ http://purl.uniprot.org/uniprot/M3XDE0 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9685:KCNU1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XLZ3|||http://purl.uniprot.org/uniprot/M3WPE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.|||Membrane http://togogenome.org/gene/9685:TAFA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWB7 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9685:TXNIP ^@ http://purl.uniprot.org/uniprot/M3XA24 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9685:RAB43 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9685:LOC101093701 ^@ http://purl.uniprot.org/uniprot/A0A5F5XN98|||http://purl.uniprot.org/uniprot/M3WFW3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9685:LZTFL1 ^@ http://purl.uniprot.org/uniprot/M3W6J9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/9685:LOC101100766 ^@ http://purl.uniprot.org/uniprot/M3VUD6 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9685:SPC24 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9685:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A5F5XSA6 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:GRN ^@ http://purl.uniprot.org/uniprot/M3WNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/9685:UTP14A ^@ http://purl.uniprot.org/uniprot/A0A337S6L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP14 family.|||nucleolus http://togogenome.org/gene/9685:LOC101084332 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/9685:ABCB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UET2|||http://purl.uniprot.org/uniprot/A0A2I2UZF6|||http://purl.uniprot.org/uniprot/D2KKF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:SLC26A2 ^@ http://purl.uniprot.org/uniprot/M3WWH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/9685:LOC101084154 ^@ http://purl.uniprot.org/uniprot/A0A2I2V102 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/9685:TCP11L2 ^@ http://purl.uniprot.org/uniprot/M3WJ71 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9685:COQ10A ^@ http://purl.uniprot.org/uniprot/M3WG67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9685:ALG8 ^@ http://purl.uniprot.org/uniprot/M3WZ59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:ATP6V1B2 ^@ http://purl.uniprot.org/uniprot/M3WIR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9685:ANKRD34A ^@ http://purl.uniprot.org/uniprot/A0A5F5XJL7 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9685:KPNA1 ^@ http://purl.uniprot.org/uniprot/A0A337S696 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9685:CXCL8 ^@ http://purl.uniprot.org/uniprot/Q9XSX5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.|||Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.|||Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.|||Secreted http://togogenome.org/gene/9685:SLC1A4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9685:GNPDA2 ^@ http://purl.uniprot.org/uniprot/M3X7J4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9685:SSTR2 ^@ http://purl.uniprot.org/uniprot/M3W2Q8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/9685:HOPX ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ93 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SNRPB ^@ http://purl.uniprot.org/uniprot/A0A2I2V053 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9685:PLAC8B ^@ http://purl.uniprot.org/uniprot/M3WCX9 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9685:PSAT1 ^@ http://purl.uniprot.org/uniprot/M3X3I1 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/9685:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A337SN10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/9685:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A2I2U7S7|||http://purl.uniprot.org/uniprot/A0A337S9S1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9685:PLK1 ^@ http://purl.uniprot.org/uniprot/M3WHX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||Midbody|||Nucleus|||centrosome http://togogenome.org/gene/9685:MST1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAP2 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:GRIN1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XFE3|||http://purl.uniprot.org/uniprot/A0A5F5XJZ8|||http://purl.uniprot.org/uniprot/A0A5F5XLT4|||http://purl.uniprot.org/uniprot/A0A5F5XYS8|||http://purl.uniprot.org/uniprot/A0A5F5Y645 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9685:ELF1 ^@ http://purl.uniprot.org/uniprot/M3WV46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:NDUFA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101097669 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZC2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NDUFAF7 ^@ http://purl.uniprot.org/uniprot/M3WN86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/9685:MRPL49 ^@ http://purl.uniprot.org/uniprot/A0A337SFG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/9685:ALDH1B1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4J8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9685:TMEM131 ^@ http://purl.uniprot.org/uniprot/A0A2I2UK82 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/9685:LOC101089767 ^@ http://purl.uniprot.org/uniprot/M3WSM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:ASL ^@ http://purl.uniprot.org/uniprot/A0A2I2UJE0 ^@ Similarity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/9685:TRAK2 ^@ http://purl.uniprot.org/uniprot/M3W5A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9685:GJA10 ^@ http://purl.uniprot.org/uniprot/M3WAF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:LOC101090352 ^@ http://purl.uniprot.org/uniprot/A0A337SGY3 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9685:HMBOX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYV9|||http://purl.uniprot.org/uniprot/M3XCJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ANKS3 ^@ http://purl.uniprot.org/uniprot/M3W2F3 ^@ Function ^@ Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9685:MCF2L ^@ http://purl.uniprot.org/uniprot/A0A2I2V4Y6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:H2AJ ^@ http://purl.uniprot.org/uniprot/M3X2B2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:CYP3A131 ^@ http://purl.uniprot.org/uniprot/F8WKX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9685:THRB ^@ http://purl.uniprot.org/uniprot/A0A2I2UCE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9685:MYF6 ^@ http://purl.uniprot.org/uniprot/M3WLS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SLC39A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC102899259 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y3T4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:LOC101092643 ^@ http://purl.uniprot.org/uniprot/A0A2I2V115 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PLPPR1 ^@ http://purl.uniprot.org/uniprot/M3VWK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9685:LOC101100247 ^@ http://purl.uniprot.org/uniprot/M3WQU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MARCO ^@ http://purl.uniprot.org/uniprot/M3WJY3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:IRAK4 ^@ http://purl.uniprot.org/uniprot/A0A337S8S7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9685:PSMC3IP ^@ http://purl.uniprot.org/uniprot/M3WFI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/9685:RIOK1 ^@ http://purl.uniprot.org/uniprot/M3X6D2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9685:DPT ^@ http://purl.uniprot.org/uniprot/M3XE34 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9685:PGGT1B ^@ http://purl.uniprot.org/uniprot/A0A337SDQ6 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/9685:NOC4L ^@ http://purl.uniprot.org/uniprot/M3WDX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||Nucleus membrane http://togogenome.org/gene/9685:LOC101080897 ^@ http://purl.uniprot.org/uniprot/M3WCX1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:GDF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4I8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9685:SH3RF2 ^@ http://purl.uniprot.org/uniprot/M3WA34 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/9685:SPG7 ^@ http://purl.uniprot.org/uniprot/M3W058 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9685:TCN2 ^@ http://purl.uniprot.org/uniprot/M3W1K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9685:POC5 ^@ http://purl.uniprot.org/uniprot/M3WBV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/9685:GUCA2A ^@ http://purl.uniprot.org/uniprot/M3W5G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9685:TENT5B ^@ http://purl.uniprot.org/uniprot/M3WD15 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9685:ATXN1 ^@ http://purl.uniprot.org/uniprot/M3WEU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9685:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A337SKY0|||http://purl.uniprot.org/uniprot/M3WLF5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:LOC101093798 ^@ http://purl.uniprot.org/uniprot/A0A5F5XLX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ASCC3 ^@ http://purl.uniprot.org/uniprot/M3X4E0 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/9685:GDPD5 ^@ http://purl.uniprot.org/uniprot/A0A2I2U292 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9685:SERPINB12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UMR7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:LOC101090464 ^@ http://purl.uniprot.org/uniprot/M3WTD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MRPS12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVJ6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/9685:LOC101099158 ^@ http://purl.uniprot.org/uniprot/A0A5F5XPR3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ACTRT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVN2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:PKIA ^@ http://purl.uniprot.org/uniprot/A0A2I2U9N8 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9685:DHRS9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFD7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:LOC101093163 ^@ http://purl.uniprot.org/uniprot/A0A337RXZ9 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/9685:PTTG1 ^@ http://purl.uniprot.org/uniprot/M3X3A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:ZCCHC8 ^@ http://purl.uniprot.org/uniprot/M3WV88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC8 family.|||nucleoplasm http://togogenome.org/gene/9685:NAA35 ^@ http://purl.uniprot.org/uniprot/A0A2I2V283 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.|||Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/9685:RPS5 ^@ http://purl.uniprot.org/uniprot/M3X5Q3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9685:CCN1 ^@ http://purl.uniprot.org/uniprot/M3WX79 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:JAK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/9685:STX19 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVU9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9685:RXRA ^@ http://purl.uniprot.org/uniprot/A0A2I2U0T0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9685:ORC3 ^@ http://purl.uniprot.org/uniprot/M3W8W0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/9685:RBM42 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCT9|||http://purl.uniprot.org/uniprot/A0A337SHS1 ^@ Similarity ^@ Belongs to the RRM RBM42 family. http://togogenome.org/gene/9685:ISY1 ^@ http://purl.uniprot.org/uniprot/M3W9Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/9685:LOC101100737 ^@ http://purl.uniprot.org/uniprot/A0A2I2UG91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TM4SF18 ^@ http://purl.uniprot.org/uniprot/M3VWD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9685:NUS1 ^@ http://purl.uniprot.org/uniprot/M3XAC4 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9685:MLEC ^@ http://purl.uniprot.org/uniprot/M3VYF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:LOC101088440 ^@ http://purl.uniprot.org/uniprot/M3WZS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9685:TLCD1 ^@ http://purl.uniprot.org/uniprot/M3W1E9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CNDP1 ^@ http://purl.uniprot.org/uniprot/M3W9A4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9685:GABRB3 ^@ http://purl.uniprot.org/uniprot/A0A337SUQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:MC4R ^@ http://purl.uniprot.org/uniprot/M3W634 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/9685:CDC6 ^@ http://purl.uniprot.org/uniprot/M3X9D7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/9685:FBXO48 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJH7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9685:AWAT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULD0|||http://purl.uniprot.org/uniprot/M3WA56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:AGL ^@ http://purl.uniprot.org/uniprot/M3X112 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/9685:PPP4R3B ^@ http://purl.uniprot.org/uniprot/M3X3M6 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9685:NCBP3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XYG5 ^@ Similarity ^@ Belongs to the NCBP3 family. http://togogenome.org/gene/9685:IMMT ^@ http://purl.uniprot.org/uniprot/A0A2I2V257|||http://purl.uniprot.org/uniprot/A0A5F5XSJ8|||http://purl.uniprot.org/uniprot/M3WAJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:PTPN14 ^@ http://purl.uniprot.org/uniprot/M3WUZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9685:THUMPD3 ^@ http://purl.uniprot.org/uniprot/M3W5F4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9685:AMT ^@ http://purl.uniprot.org/uniprot/A0A337SVD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9685:NR4A2 ^@ http://purl.uniprot.org/uniprot/M3WFK9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9685:HEATR5A ^@ http://purl.uniprot.org/uniprot/A0A337SQL6|||http://purl.uniprot.org/uniprot/M3WLA0 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/9685:SLC25A20 ^@ http://purl.uniprot.org/uniprot/M3X6S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:CES2 ^@ http://purl.uniprot.org/uniprot/M3W105 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9685:LOC101091367 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y142 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ITGA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2USG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9685:EXTL2 ^@ http://purl.uniprot.org/uniprot/A0A337S6P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:LOC101100165 ^@ http://purl.uniprot.org/uniprot/M3W7M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MAK16 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3N6 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9685:AIDA ^@ http://purl.uniprot.org/uniprot/M3VY63 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9685:NDRG3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UN34|||http://purl.uniprot.org/uniprot/A0A2I2UPL8 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9685:MAPT ^@ http://purl.uniprot.org/uniprot/A0A337S3K6|||http://purl.uniprot.org/uniprot/A0A337S885|||http://purl.uniprot.org/uniprot/A0A337SDC9|||http://purl.uniprot.org/uniprot/A0A337SDL5|||http://purl.uniprot.org/uniprot/M3W6D2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||axon|||cytoskeleton|||cytosol|||dendrite http://togogenome.org/gene/9685:ZIC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTD3 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9685:RAD23B ^@ http://purl.uniprot.org/uniprot/M3WPZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9685:LOC101099214 ^@ http://purl.uniprot.org/uniprot/M3X2L5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101084939 ^@ http://purl.uniprot.org/uniprot/M3WAR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:BNIP3L ^@ http://purl.uniprot.org/uniprot/M3XF65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/9685:WLS ^@ http://purl.uniprot.org/uniprot/A0A5F5XS95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:TMEM138 ^@ http://purl.uniprot.org/uniprot/M3XF15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/9685:MCHR1 ^@ http://purl.uniprot.org/uniprot/M3WML9 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/9685:DPAGT1 ^@ http://purl.uniprot.org/uniprot/M3VW37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:PM20D2 ^@ http://purl.uniprot.org/uniprot/M3WKB5 ^@ Function|||Similarity ^@ Belongs to the peptidase M20A family.|||Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. http://togogenome.org/gene/9685:PICALM ^@ http://purl.uniprot.org/uniprot/M3XEB8 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/9685:PRKAR2A ^@ http://purl.uniprot.org/uniprot/A0A337S4R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:INTS7 ^@ http://purl.uniprot.org/uniprot/M3WAQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9685:SERPINA5 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y664|||http://purl.uniprot.org/uniprot/M3WCX5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:TAFA1 ^@ http://purl.uniprot.org/uniprot/A0A337S5A6 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9685:MYH6 ^@ http://purl.uniprot.org/uniprot/M3WAS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||myofibril http://togogenome.org/gene/9685:LOC101099406 ^@ http://purl.uniprot.org/uniprot/M3WWR4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:HDAC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULD8|||http://purl.uniprot.org/uniprot/A0A2I2UTS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/9685:YWHAQ ^@ http://purl.uniprot.org/uniprot/M3W8I2 ^@ Function|||Similarity ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|||Belongs to the 14-3-3 family. http://togogenome.org/gene/9685:LOC101091873 ^@ http://purl.uniprot.org/uniprot/M3X3A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/9685:ITGA5 ^@ http://purl.uniprot.org/uniprot/M3WCS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9685:SEC22A ^@ http://purl.uniprot.org/uniprot/A0A5K1V296|||http://purl.uniprot.org/uniprot/M3WTX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9685:RAB38 ^@ http://purl.uniprot.org/uniprot/M3W9L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9685:VCL ^@ http://purl.uniprot.org/uniprot/M3XCV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.|||Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||podosome http://togogenome.org/gene/9685:CEP290 ^@ http://purl.uniprot.org/uniprot/A6Y7R7 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9685:THAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3T1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9685:CASP3 ^@ http://purl.uniprot.org/uniprot/Q8MJU1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C14A family.|||Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.|||Cytoplasm|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.|||Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity).|||S-nitrosylated on its catalytic site cysteine in unstimulated cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol. http://togogenome.org/gene/9685:ACKR4 ^@ http://purl.uniprot.org/uniprot/M3W144 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:PIGH ^@ http://purl.uniprot.org/uniprot/A0A2I2USE5 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/9685:CACNB4 ^@ http://purl.uniprot.org/uniprot/A0A337SFX8|||http://purl.uniprot.org/uniprot/M3X185|||http://purl.uniprot.org/uniprot/M3XBX7 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9685:RHBDD2 ^@ http://purl.uniprot.org/uniprot/M3X5I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CALB2 ^@ http://purl.uniprot.org/uniprot/M3WCV4 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/9685:CSTF2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XJN8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101082905 ^@ http://purl.uniprot.org/uniprot/A0A337RYZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9685:NDUFV1 ^@ http://purl.uniprot.org/uniprot/M3VX83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:SF3B1 ^@ http://purl.uniprot.org/uniprot/M3W3C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/9685:STXBP1 ^@ http://purl.uniprot.org/uniprot/A0A337S4W7|||http://purl.uniprot.org/uniprot/A0A337SWE3 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9685:MTG1 ^@ http://purl.uniprot.org/uniprot/A0A337S1W7|||http://purl.uniprot.org/uniprot/M3WXQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Mitochondrion inner membrane|||Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity. http://togogenome.org/gene/9685:LOC102899587 ^@ http://purl.uniprot.org/uniprot/A0A654IDG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:DUSP12 ^@ http://purl.uniprot.org/uniprot/M3W933 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9685:LAMTOR4 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y7N9 ^@ Similarity ^@ Belongs to the LAMTOR4 family. http://togogenome.org/gene/9685:MMP12 ^@ http://purl.uniprot.org/uniprot/M3WEA4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:RLN ^@ http://purl.uniprot.org/uniprot/Q9MYK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the insulin family.|||Expressed by the placenta. Exclusively detected in cells located in the lamellar placental labyrinth and absent from other placental and non-placental uterine parts.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.|||Secreted http://togogenome.org/gene/9685:NT5DC1 ^@ http://purl.uniprot.org/uniprot/M3WIT8 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/9685:TENT5A ^@ http://purl.uniprot.org/uniprot/A0A2I2V069 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9685:LOC102899079 ^@ http://purl.uniprot.org/uniprot/M3WWC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:OPA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UF97|||http://purl.uniprot.org/uniprot/A0A337SN50|||http://purl.uniprot.org/uniprot/M3VV89 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9685:PIR ^@ http://purl.uniprot.org/uniprot/M3WDC7 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/9685:TRPC7 ^@ http://purl.uniprot.org/uniprot/M3WIH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101100505 ^@ http://purl.uniprot.org/uniprot/M3XFG8 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PTH2 ^@ http://purl.uniprot.org/uniprot/M3VWT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/9685:LOC101085650 ^@ http://purl.uniprot.org/uniprot/A0A2I2U850 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:TGM5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UM78|||http://purl.uniprot.org/uniprot/A0A2I2UX75 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9685:LEF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3V9|||http://purl.uniprot.org/uniprot/A0A337SI72|||http://purl.uniprot.org/uniprot/A0A337SR54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9685:PLA2G15 ^@ http://purl.uniprot.org/uniprot/M3X3D3 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9685:SCG3 ^@ http://purl.uniprot.org/uniprot/M3WH66 ^@ Subcellular Location Annotation ^@ Membrane|||Secreted|||secretory vesicle membrane http://togogenome.org/gene/9685:RPL27 ^@ http://purl.uniprot.org/uniprot/M3WIA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/9685:SLC35A4 ^@ http://purl.uniprot.org/uniprot/M3VWC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:LOC105260969 ^@ http://purl.uniprot.org/uniprot/A0A2I2UF41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ERF ^@ http://purl.uniprot.org/uniprot/M3X163 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:KRT82 ^@ http://purl.uniprot.org/uniprot/M3VUF5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:MED7 ^@ http://purl.uniprot.org/uniprot/M3WLT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9685:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A2I2U221|||http://purl.uniprot.org/uniprot/M3WNF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/9685:SLC9A3R1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UP60 ^@ Function|||Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/9685:B3GNT5 ^@ http://purl.uniprot.org/uniprot/M3WYR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:CRYGB ^@ http://purl.uniprot.org/uniprot/M3W1B4 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:CABS1 ^@ http://purl.uniprot.org/uniprot/M3X763 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane|||Mitochondrion inner membrane|||flagellum http://togogenome.org/gene/9685:NDUFV2 ^@ http://purl.uniprot.org/uniprot/A0A337RZR2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9685:LOC101094818 ^@ http://purl.uniprot.org/uniprot/M3X5N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CYP27A1 ^@ http://purl.uniprot.org/uniprot/M3W709 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9685:MFSD8 ^@ http://purl.uniprot.org/uniprot/A0A337SPS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GAPDH ^@ http://purl.uniprot.org/uniprot/A0A0A0MPZ5|||http://purl.uniprot.org/uniprot/Q9N2D5 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Glyceraldehyde-3-phosphate dehydrogenase activity is inhibited by fumarate, via the formation of S-(2-succinyl)cysteine residues.|||Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).|||Homotetramer (By similarity). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity. Interacts with TRAF2, promoting TRAF2 ubiquitination. Interacts with TRAF3, promoting TRAF3 ubiquitination (By similarity).|||Homotetramer.|||ISGylated.|||Nucleus|||Oxidative stress can promote the formation of high molecular weight disulfide-linked GAPDH aggregates, through a process called nucleocytoplasmic coagulation.|||S-nitrosylation of Cys-150 leads to interaction with SIAH1, followed by translocation to the nucleus S-nitrosylation of Cys-245 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity).|||Sulfhydration at Cys-150 increases catalytic activity.|||The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.|||cytoskeleton|||cytosol http://togogenome.org/gene/9685:LBH ^@ http://purl.uniprot.org/uniprot/A0A2I2UXT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||Transcriptional activator. http://togogenome.org/gene/9685:ANTKMT ^@ http://purl.uniprot.org/uniprot/A0A2I2V2F8|||http://purl.uniprot.org/uniprot/A0A337S4G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/9685:MCPH1 ^@ http://purl.uniprot.org/uniprot/Q6PYB8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.|||Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.|||centrosome http://togogenome.org/gene/9685:SYN1 ^@ http://purl.uniprot.org/uniprot/M3W948 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9685:PSKH2 ^@ http://purl.uniprot.org/uniprot/M3X5M6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:PNLIPRP3 ^@ http://purl.uniprot.org/uniprot/M3XDN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9685:AREG ^@ http://purl.uniprot.org/uniprot/M3VUM2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:DHFR ^@ http://purl.uniprot.org/uniprot/A0A337SMR3 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/9685:CLDN18 ^@ http://purl.uniprot.org/uniprot/M3VXB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9685:FADD ^@ http://purl.uniprot.org/uniprot/A0A337SGT5 ^@ Function ^@ Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. http://togogenome.org/gene/9685:LOC101097811 ^@ http://purl.uniprot.org/uniprot/A0A5F5XT49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MPC2 ^@ http://purl.uniprot.org/uniprot/A0A337RX71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:RSAD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:CAPZB ^@ http://purl.uniprot.org/uniprot/A0A337S8B2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/9685:PTPRB ^@ http://purl.uniprot.org/uniprot/A0A2I2UMZ2|||http://purl.uniprot.org/uniprot/A0A5F5XP09|||http://purl.uniprot.org/uniprot/M3WCC4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. http://togogenome.org/gene/9685:LOC105260478 ^@ http://purl.uniprot.org/uniprot/A0A5F5XMT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9685:TPMT ^@ http://purl.uniprot.org/uniprot/M3W1W1|||http://purl.uniprot.org/uniprot/Q6EIC1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9685:RAB3D ^@ http://purl.uniprot.org/uniprot/M3VYK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9685:CDK3 ^@ http://purl.uniprot.org/uniprot/M3W4N5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:TMEM47 ^@ http://purl.uniprot.org/uniprot/M3X238 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9685:FEN1 ^@ http://purl.uniprot.org/uniprot/M3WJB0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9685:DCTN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNT0|||http://purl.uniprot.org/uniprot/A0A2I2UWJ5|||http://purl.uniprot.org/uniprot/A0A337SCA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9685:LPAR6 ^@ http://purl.uniprot.org/uniprot/A0A5F5XLZ8|||http://purl.uniprot.org/uniprot/G9JVS7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:HSD17B10 ^@ http://purl.uniprot.org/uniprot/M3WJP6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:TSNAX ^@ http://purl.uniprot.org/uniprot/M3X5Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/9685:LYZL4 ^@ http://purl.uniprot.org/uniprot/M3WAH3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9685:LIX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCV9|||http://purl.uniprot.org/uniprot/Q0H3B2 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9685:LOC101082491 ^@ http://purl.uniprot.org/uniprot/M3WSM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:KIF18A ^@ http://purl.uniprot.org/uniprot/M3XGD9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:GIMAP5 ^@ http://purl.uniprot.org/uniprot/A0A2I2U613 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9685:CD44 ^@ http://purl.uniprot.org/uniprot/A0A337S5E8|||http://purl.uniprot.org/uniprot/A0A337SF56|||http://purl.uniprot.org/uniprot/A0A5F5Y0M0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/9685:BCAT1 ^@ http://purl.uniprot.org/uniprot/M3W9W3 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9685:LOC101086841 ^@ http://purl.uniprot.org/uniprot/A0A337S806 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:HSPB1 ^@ http://purl.uniprot.org/uniprot/M3WWP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus|||spindle http://togogenome.org/gene/9685:HAPLN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXX9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9685:LOC101088007 ^@ http://purl.uniprot.org/uniprot/M3WXL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SLC35A5 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y716|||http://purl.uniprot.org/uniprot/M3WWS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:MC5R ^@ http://purl.uniprot.org/uniprot/M3VY79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. http://togogenome.org/gene/9685:TBX18 ^@ http://purl.uniprot.org/uniprot/A0A337S3K3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9685:LOC101088417 ^@ http://purl.uniprot.org/uniprot/A0A337S7L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9685:ATP8B1 ^@ http://purl.uniprot.org/uniprot/M3WKG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9685:NUDT2 ^@ http://purl.uniprot.org/uniprot/M3X650 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9685:GABRP ^@ http://purl.uniprot.org/uniprot/M3W0Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:ITIH5 ^@ http://purl.uniprot.org/uniprot/M3WEM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9685:PIGO ^@ http://purl.uniprot.org/uniprot/M3VW07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:COMTD1 ^@ http://purl.uniprot.org/uniprot/M3W3F6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9685:CD1H11orf49 ^@ http://purl.uniprot.org/uniprot/A0A2I2TZV6|||http://purl.uniprot.org/uniprot/M3VYN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/9685:ALG14 ^@ http://purl.uniprot.org/uniprot/M3W554 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9685:ACAD11 ^@ http://purl.uniprot.org/uniprot/M3WUQ8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9685:GALT ^@ http://purl.uniprot.org/uniprot/M3WNC7 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9685:PIH1D2 ^@ http://purl.uniprot.org/uniprot/A0A337S8L6|||http://purl.uniprot.org/uniprot/M3VV32 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9685:KRT17 ^@ http://purl.uniprot.org/uniprot/M3WI20 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:TSEN34 ^@ http://purl.uniprot.org/uniprot/M3WJZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9685:RELL2 ^@ http://purl.uniprot.org/uniprot/M3W6Q3 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9685:TARS1 ^@ http://purl.uniprot.org/uniprot/A0A337SRL7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:TDP2 ^@ http://purl.uniprot.org/uniprot/M3WQI6 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9685:AIFM1 ^@ http://purl.uniprot.org/uniprot/A0A337SKT2|||http://purl.uniprot.org/uniprot/M3W9M2 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/9685:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/M3XBK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9685:FELCATV1R12 ^@ http://purl.uniprot.org/uniprot/A0A0A0Y877 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SAXO1 ^@ http://purl.uniprot.org/uniprot/M3W2Y6 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/9685:NLK ^@ http://purl.uniprot.org/uniprot/M3W7I9 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9685:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJQ8|||http://purl.uniprot.org/uniprot/M3VWF3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9685:GALNT1 ^@ http://purl.uniprot.org/uniprot/M3WYS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:TEX261 ^@ http://purl.uniprot.org/uniprot/M3WIW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/9685:CSTA ^@ http://purl.uniprot.org/uniprot/Q8WNR9 ^@ Allergen|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Causes an allergic reaction in human. Binds to IgE.|||Cytoplasm|||This is an intracellular thiol proteinase inhibitor. http://togogenome.org/gene/9685:CRH ^@ http://purl.uniprot.org/uniprot/M3VX86|||http://purl.uniprot.org/uniprot/Q1HCN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/9685:DPF2 ^@ http://purl.uniprot.org/uniprot/M3X3X4 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9685:CCN4 ^@ http://purl.uniprot.org/uniprot/M3X2T4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:RPL22 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNG3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9685:GPRC5D ^@ http://purl.uniprot.org/uniprot/A0A337RVG2|||http://purl.uniprot.org/uniprot/M3WJV8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:TBC1D23 ^@ http://purl.uniprot.org/uniprot/M3W963 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9685:CYP2F1 ^@ http://purl.uniprot.org/uniprot/M3WWL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Membrane|||Microsome membrane http://togogenome.org/gene/9685:DMTN ^@ http://purl.uniprot.org/uniprot/A0A337RXR9|||http://purl.uniprot.org/uniprot/A0A337SPC7|||http://purl.uniprot.org/uniprot/M3WHZ4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:YIPF5 ^@ http://purl.uniprot.org/uniprot/M3XCX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9685:RNF13 ^@ http://purl.uniprot.org/uniprot/M3WD03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ACSL6 ^@ http://purl.uniprot.org/uniprot/M3X4S1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:PUF60 ^@ http://purl.uniprot.org/uniprot/A0A337SJ38|||http://purl.uniprot.org/uniprot/A0A337SVM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/9685:VIP ^@ http://purl.uniprot.org/uniprot/M3VY16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9685:LOC101082235 ^@ http://purl.uniprot.org/uniprot/M3X6T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:FSHR ^@ http://purl.uniprot.org/uniprot/A0A2I2V553|||http://purl.uniprot.org/uniprot/Q5GJ04 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (By similarity).|||Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation.|||Membrane|||N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.|||Sulfated. http://togogenome.org/gene/9685:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9685:DPEP1 ^@ http://purl.uniprot.org/uniprot/Q0PDI8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9685:SCN1A ^@ http://purl.uniprot.org/uniprot/A0A2I2UDI4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9685:METTL4 ^@ http://purl.uniprot.org/uniprot/M3WNV8 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9685:MAP3K8 ^@ http://purl.uniprot.org/uniprot/M3W239 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9685:DAXX ^@ http://purl.uniprot.org/uniprot/M3W1E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAXX family.|||Cytoplasm|||PML body|||centromere|||nucleolus|||nucleoplasm http://togogenome.org/gene/9685:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0R5|||http://purl.uniprot.org/uniprot/A0A337SDW4|||http://purl.uniprot.org/uniprot/M3WP74 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9685:SLC43A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V072|||http://purl.uniprot.org/uniprot/M3W5M5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CDC123 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUM3|||http://purl.uniprot.org/uniprot/A0A337SI74|||http://purl.uniprot.org/uniprot/M3X1J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9685:KCNJ16 ^@ http://purl.uniprot.org/uniprot/M3XAF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9685:PNKD ^@ http://purl.uniprot.org/uniprot/A0A5F5XE86 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9685:LOC101088781 ^@ http://purl.uniprot.org/uniprot/M3X4S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DNAJA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U399 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TP53I11 ^@ http://purl.uniprot.org/uniprot/A0A337S1D2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CLIC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2TZW5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9685:ATP5F1B ^@ http://purl.uniprot.org/uniprot/M3WG78 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9685:ST7 ^@ http://purl.uniprot.org/uniprot/A0A337SGG0|||http://purl.uniprot.org/uniprot/A0M8T0|||http://purl.uniprot.org/uniprot/A0M8T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9685:NFU1 ^@ http://purl.uniprot.org/uniprot/M3X3Q1 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/9685:CORO6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UR48|||http://purl.uniprot.org/uniprot/A0A2I2UVQ7 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9685:CAPZA1 ^@ http://purl.uniprot.org/uniprot/M3WIM3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9685:NAPA ^@ http://purl.uniprot.org/uniprot/M3W5E1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9685:LOC101087365 ^@ http://purl.uniprot.org/uniprot/M3WQ25 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:POLL ^@ http://purl.uniprot.org/uniprot/M3WN40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9685:LOC101083875 ^@ http://purl.uniprot.org/uniprot/A0A2I2UT92 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9685:DPYD ^@ http://purl.uniprot.org/uniprot/A0A2I2UPM5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/9685:COPS5 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9685:CF1H1orf74 ^@ http://purl.uniprot.org/uniprot/M3WM05 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/9685:GFOD1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XVF0 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9685:NAA38 ^@ http://purl.uniprot.org/uniprot/A0A337S497 ^@ Function|||Similarity|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.|||Belongs to the snRNP Sm proteins family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. http://togogenome.org/gene/9685:MAPRE3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9685:MYL5 ^@ http://purl.uniprot.org/uniprot/P41691 ^@ Miscellaneous|||Subunit|||Tissue Specificity ^@ Jaw-closing muscles.|||Myosin is a hexamer of 2 heavy chains and 4 light chains.|||This chain binds calcium. http://togogenome.org/gene/9685:GNG8 ^@ http://purl.uniprot.org/uniprot/M3WBR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9685:LOC101100954 ^@ http://purl.uniprot.org/uniprot/A0A2I2UDK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9685:CHEK1 ^@ http://purl.uniprot.org/uniprot/M3WLY2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9685:ST6GALNAC5 ^@ http://purl.uniprot.org/uniprot/M3X4H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:OCIAD1 ^@ http://purl.uniprot.org/uniprot/M3X1S5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9685:LRRFIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y103 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9685:ORMDL1 ^@ http://purl.uniprot.org/uniprot/A0A337S5E0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9685:SERPINB10 ^@ http://purl.uniprot.org/uniprot/M3W9H4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:LOC101100266 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCG4 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9685:LOC101081755 ^@ http://purl.uniprot.org/uniprot/M3X4M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/M3X8U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9685:SNRPD2 ^@ http://purl.uniprot.org/uniprot/M3X0Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||cytosol http://togogenome.org/gene/9685:SLC27A1 ^@ http://purl.uniprot.org/uniprot/M3W7U2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:KRT33A ^@ http://purl.uniprot.org/uniprot/M3VXJ5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:SATB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V398|||http://purl.uniprot.org/uniprot/M3W1Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9685:LOC101097653 ^@ http://purl.uniprot.org/uniprot/A0A337S9C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MET ^@ http://purl.uniprot.org/uniprot/A0M8S8 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by PTPN1 and PTPN2 (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).|||In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).|||Membrane|||O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.|||Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).|||The beta-propeller Sema domain mediates binding to HGF.|||The kinase domain is involved in SPSB1 binding.|||Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity). http://togogenome.org/gene/9685:DDX24 ^@ http://purl.uniprot.org/uniprot/M3WCW8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9685:SARAF ^@ http://purl.uniprot.org/uniprot/A0A2I2URF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SARAF family.|||Endoplasmic reticulum membrane|||Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.|||Membrane|||Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. http://togogenome.org/gene/9685:SLC10A7 ^@ http://purl.uniprot.org/uniprot/A0A337SJU6|||http://purl.uniprot.org/uniprot/A0A337SLX6|||http://purl.uniprot.org/uniprot/M3VZM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Cell membrane|||Does not show transport activity towards bile acids or steroid sulfates.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9685:SLC25A53 ^@ http://purl.uniprot.org/uniprot/M3X853 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:ORMDL3 ^@ http://purl.uniprot.org/uniprot/M3X8M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9685:PSMC6 ^@ http://purl.uniprot.org/uniprot/M3WNQ7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9685:PADI3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4T3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9685:CA1 ^@ http://purl.uniprot.org/uniprot/M3XGD6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9685:GET3 ^@ http://purl.uniprot.org/uniprot/M3VUU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/9685:EMP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9685:NUSAP1 ^@ http://purl.uniprot.org/uniprot/M3WH94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NUSAP family.|||Cytoplasm http://togogenome.org/gene/9685:UGT8 ^@ http://purl.uniprot.org/uniprot/M3WVI1 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/9685:LOC101090367 ^@ http://purl.uniprot.org/uniprot/M3W2L7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9685:LOC101098693 ^@ http://purl.uniprot.org/uniprot/M3WR61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:AK1 ^@ http://purl.uniprot.org/uniprot/M3WX07 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9685:GALNT17 ^@ http://purl.uniprot.org/uniprot/M3WMF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:CLSTN2 ^@ http://purl.uniprot.org/uniprot/A0A337S946|||http://purl.uniprot.org/uniprot/M3VYH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/9685:TRAPPC11 ^@ http://purl.uniprot.org/uniprot/M3WTQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPPC11 family.|||Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.|||cis-Golgi network http://togogenome.org/gene/9685:AHCYL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2US36|||http://purl.uniprot.org/uniprot/M3XD17 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9685:IRF6 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4A6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:POFUT1 ^@ http://purl.uniprot.org/uniprot/M3WRS8 ^@ Similarity ^@ Belongs to the glycosyltransferase 65 family. http://togogenome.org/gene/9685:SLA ^@ http://purl.uniprot.org/uniprot/A0A2I2U783 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:LSM8 ^@ http://purl.uniprot.org/uniprot/A0A2I2UY34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/9685:DRD2 ^@ http://purl.uniprot.org/uniprot/M3W9B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:ABI2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3N8|||http://purl.uniprot.org/uniprot/A0A337S1B2|||http://purl.uniprot.org/uniprot/A0A337SDU6|||http://purl.uniprot.org/uniprot/A0A5F5Y6F1|||http://purl.uniprot.org/uniprot/M3WHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9685:LOC101090262 ^@ http://purl.uniprot.org/uniprot/M3X6T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:RPL10A ^@ http://purl.uniprot.org/uniprot/M3WHU6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/9685:RNF168 ^@ http://purl.uniprot.org/uniprot/M3WSK4 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Belongs to the RNF168 family.|||E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with UBE2N/UBC13.|||Nucleus|||Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).|||The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).|||Ubiquitinated. http://togogenome.org/gene/9685:HOXC10 ^@ http://purl.uniprot.org/uniprot/M3WEN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9685:ASTE1 ^@ http://purl.uniprot.org/uniprot/M3VW44 ^@ Similarity ^@ Belongs to the asteroid family. http://togogenome.org/gene/9685:PRMT3 ^@ http://purl.uniprot.org/uniprot/M3WWS1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:LOC101082261 ^@ http://purl.uniprot.org/uniprot/M3XB67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PCLAF ^@ http://purl.uniprot.org/uniprot/M3X1C5 ^@ Subcellular Location Annotation ^@ Nucleus|||perinuclear region http://togogenome.org/gene/9685:SLC5A11 ^@ http://purl.uniprot.org/uniprot/M3WLT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LUC7L3 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6A9|||http://purl.uniprot.org/uniprot/M3WGR7 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9685:EIPR1 ^@ http://purl.uniprot.org/uniprot/M3WAK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EIPR1 family.|||trans-Golgi network http://togogenome.org/gene/9685:PLA2G4F ^@ http://purl.uniprot.org/uniprot/M3XAF2 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9685:SQLE ^@ http://purl.uniprot.org/uniprot/M3X722 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:MON1B ^@ http://purl.uniprot.org/uniprot/M3W1K5 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/9685:KCNN2 ^@ http://purl.uniprot.org/uniprot/M3X7U2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:KIF3B ^@ http://purl.uniprot.org/uniprot/M3X169 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:PTCD2 ^@ http://purl.uniprot.org/uniprot/A0A337RYJ8|||http://purl.uniprot.org/uniprot/A0A5F5Y7D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTCD2 family.|||Mitochondrion http://togogenome.org/gene/9685:ITGB8 ^@ http://purl.uniprot.org/uniprot/M3W6P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||Recycling endosome|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9685:ZRANB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2URP9 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/9685:GLB1 ^@ http://purl.uniprot.org/uniprot/O19015 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 35 family.|||Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.|||Homodimer. May form higher multimers.|||Lysosome http://togogenome.org/gene/9685:TNS2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XQ99|||http://purl.uniprot.org/uniprot/M3VUH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9685:STEAP1 ^@ http://purl.uniprot.org/uniprot/M3X2G9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/A0A337SNU8 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/9685:CIAO2B ^@ http://purl.uniprot.org/uniprot/M3WPZ0 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9685:LALBA ^@ http://purl.uniprot.org/uniprot/A0A5F5XQC8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9685:SMARCD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTR2 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/9685:CNFN ^@ http://purl.uniprot.org/uniprot/M3WHI3 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9685:NPY4R2 ^@ http://purl.uniprot.org/uniprot/M3X9R9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:PPIH ^@ http://purl.uniprot.org/uniprot/G3XEW8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9685:LPIN2 ^@ http://purl.uniprot.org/uniprot/M3WQ22 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9685:LIN7C ^@ http://purl.uniprot.org/uniprot/A0A2I2V095 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9685:KCNJ12 ^@ http://purl.uniprot.org/uniprot/A0A337RXG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PHPT1 ^@ http://purl.uniprot.org/uniprot/M3X816 ^@ Function|||Similarity ^@ Belongs to the janus family.|||Exhibits phosphohistidine phosphatase activity. http://togogenome.org/gene/9685:TAAR4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7I9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:STAC3 ^@ http://purl.uniprot.org/uniprot/M3VU94 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9685:FLCN ^@ http://purl.uniprot.org/uniprot/M3W4J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9685:LOC101082834 ^@ http://purl.uniprot.org/uniprot/M3WVG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PARL ^@ http://purl.uniprot.org/uniprot/M3VZR3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULK3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9685:NEDD9 ^@ http://purl.uniprot.org/uniprot/A0A2I2U357|||http://purl.uniprot.org/uniprot/A0A5F5Y5Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9685:LOC101089545 ^@ http://purl.uniprot.org/uniprot/M3XA86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DIS3L2 ^@ http://purl.uniprot.org/uniprot/M3WH44 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.|||Belongs to the RNR ribonuclease family. DIS3L2 subfamily.|||Cytoplasm|||P-body|||Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. http://togogenome.org/gene/9685:SEPTIN11 ^@ http://purl.uniprot.org/uniprot/A0A2I2U374|||http://purl.uniprot.org/uniprot/A0A2I2UFN9|||http://purl.uniprot.org/uniprot/A0A2I2UN68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9685:DHRS7 ^@ http://purl.uniprot.org/uniprot/M3WDG4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:PDGFB ^@ http://purl.uniprot.org/uniprot/W5LV43 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9685:EXOSC2 ^@ http://purl.uniprot.org/uniprot/M3X981 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9685:LOC101091916 ^@ http://purl.uniprot.org/uniprot/M3WRL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9685:MIP ^@ http://purl.uniprot.org/uniprot/M3WG74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:RNF146 ^@ http://purl.uniprot.org/uniprot/M3WM22 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/9685:PFDN2 ^@ http://purl.uniprot.org/uniprot/M3WGQ1 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9685:MYMK ^@ http://purl.uniprot.org/uniprot/A0A2I2V1H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:TRMT5 ^@ http://purl.uniprot.org/uniprot/M3W6J5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/9685:CH2 ^@ http://purl.uniprot.org/uniprot/P30440 ^@ Allergen|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the secretoglobin family.|||Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.|||Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.|||Secreted|||The long form is preferentially expressed in the salivary gland, while the short form is preferentially expressed in the skin. http://togogenome.org/gene/9685:ADCK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Secreted http://togogenome.org/gene/9685:HABP2 ^@ http://purl.uniprot.org/uniprot/M3WFU5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:TWSG1 ^@ http://purl.uniprot.org/uniprot/M3X4Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/9685:TOMT ^@ http://purl.uniprot.org/uniprot/A0A337S8Z2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9685:PLN ^@ http://purl.uniprot.org/uniprot/M3W4A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9685:LOC101086846 ^@ http://purl.uniprot.org/uniprot/A0A2I2U6N1 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9685:FAM102A ^@ http://purl.uniprot.org/uniprot/M3VWR8 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9685:LOC101083056 ^@ http://purl.uniprot.org/uniprot/M3X296 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SLC35F4 ^@ http://purl.uniprot.org/uniprot/A0A337SXC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9685:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/M3WA37 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9685:GJD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:RTBDN ^@ http://purl.uniprot.org/uniprot/M3WCE9 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9685:MAP4K1 ^@ http://purl.uniprot.org/uniprot/A0A337SHY9 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/9685:TM7SF3 ^@ http://purl.uniprot.org/uniprot/M3XFJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CNTN2 ^@ http://purl.uniprot.org/uniprot/M3W6D4 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9685:IPO8 ^@ http://purl.uniprot.org/uniprot/A0A337SC08|||http://purl.uniprot.org/uniprot/M3X3T1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:LOC101093328 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CSF3 ^@ http://purl.uniprot.org/uniprot/Q9GJU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.|||Monomer.|||Secreted http://togogenome.org/gene/9685:USP14 ^@ http://purl.uniprot.org/uniprot/A0A5F5XQG5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/9685:TMEFF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBW6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:COG7 ^@ http://purl.uniprot.org/uniprot/M3W3L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:MLN ^@ http://purl.uniprot.org/uniprot/Q9XSE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.|||Secreted http://togogenome.org/gene/9685:ADRB2 ^@ http://purl.uniprot.org/uniprot/Q9TST5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).|||Binds NHERF1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (By similarity). Interacts with USP20 and USP33 (By similarity). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4. Interacts with ARRDC3. Interacts with NEDD4 (By similarity). Interacts with MARCHF2 (By similarity).|||Cell membrane|||Early endosome|||Golgi apparatus|||Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.|||Palmitoylated. Mainly palmitoylated at Cys-341. Palmitoylation may reduce accessibility of phosphorylation sites by anchoring the receptor to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Also undergoes transient, ligand-induced palmitoylation at Cys-265 probably by ZDHHC9, ZDHHC14 and ZDHHC18 within the Golgi. Palmitoylation at Cys-265 requires phosphorylation by PKA and receptor internalization and stabilizes the receptor. Could be depalmitoylated by LYPLA1 at the plasma membrane.|||Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity).|||Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.|||Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.|||Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent (By similarity). http://togogenome.org/gene/9685:KIFC1 ^@ http://purl.uniprot.org/uniprot/M3WJ86 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:ITGB3 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:MC1R ^@ http://purl.uniprot.org/uniprot/Q7YSE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/9685:GFOD2 ^@ http://purl.uniprot.org/uniprot/M3W0F7 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9685:ARL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYM5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9685:ASIC2 ^@ http://purl.uniprot.org/uniprot/M3WNP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:MASP2 ^@ http://purl.uniprot.org/uniprot/M3VU02 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:VEPH1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3G9|||http://purl.uniprot.org/uniprot/A0A2I2V484 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/9685:NR2C1 ^@ http://purl.uniprot.org/uniprot/M3X424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9685:RBM8A ^@ http://purl.uniprot.org/uniprot/A0A2I2V431 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/9685:PVALB ^@ http://purl.uniprot.org/uniprot/M3WNR8 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9685:SLC1A5 ^@ http://purl.uniprot.org/uniprot/M3W4L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9685:AHDC1 ^@ http://purl.uniprot.org/uniprot/M3W8J2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PSMB9 ^@ http://purl.uniprot.org/uniprot/M3X308 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:RIBC1 ^@ http://purl.uniprot.org/uniprot/M3WJP5 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9685:SH2D1A ^@ http://purl.uniprot.org/uniprot/M3W9F7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/9685:MMRN1 ^@ http://purl.uniprot.org/uniprot/M3WI37 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SGMS2 ^@ http://purl.uniprot.org/uniprot/M3WGN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9685:TNFSF10 ^@ http://purl.uniprot.org/uniprot/B4XH67 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9685:ALAS1 ^@ http://purl.uniprot.org/uniprot/M3WN44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:SFRP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UR94 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:FOS ^@ http://purl.uniprot.org/uniprot/Q8HZP6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family. Fos subfamily.|||Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-233 (By similarity).|||Endoplasmic reticulum|||Heterodimer; with JUN (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1-binding site (By similarity). Interacts with SMAD3; the interaction is weak even on TGF-beta activation (By similarity). Interacts with MAFB (By similarity). Interacts with TSC22D3 (via N-terminus); this interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with CDS1 and PI4K2A (By similarity). Interacts (via bZIP domain and leucine-zipper region) with the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF) subunits SMARCB1, SMARCC2 and SMARCD1 (By similarity). Interacts (via bZIP domain and leucine-zipper region) with ARID1A (By similarity).|||In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis (By similarity).|||Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity).|||Nucleus|||Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-363 and Ser-375 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-375 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-363 and Ser-375 primes further phosphorylations on Thr-326 and Thr-332 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-233, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-363 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).|||cytosol http://togogenome.org/gene/9685:KCNH5 ^@ http://purl.uniprot.org/uniprot/M3WD34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:FMO2 ^@ http://purl.uniprot.org/uniprot/M3W9L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9685:ALOXE3 ^@ http://purl.uniprot.org/uniprot/M3WM46 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:DDX58 ^@ http://purl.uniprot.org/uniprot/M3VWD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9685:RIPPLY1 ^@ http://purl.uniprot.org/uniprot/A0A2I2URM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9685:ATP2B1 ^@ http://purl.uniprot.org/uniprot/M3W822 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:TRADD ^@ http://purl.uniprot.org/uniprot/A0A337S5N8 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/9685:BUD31 ^@ http://purl.uniprot.org/uniprot/M3X8H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9685:ELAC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYF7 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/9685:ACSS1 ^@ http://purl.uniprot.org/uniprot/M3WKW5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:BRAF ^@ http://purl.uniprot.org/uniprot/A0A2I2ULH6|||http://purl.uniprot.org/uniprot/M3WHQ7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9685:FAM20B ^@ http://purl.uniprot.org/uniprot/M3W3U4 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9685:TMEM50A ^@ http://purl.uniprot.org/uniprot/M3WHL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9685:TMEM126A ^@ http://purl.uniprot.org/uniprot/M3WQ15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:SERPINA6 ^@ http://purl.uniprot.org/uniprot/M3WCX0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:PADI4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9685:TM7SF2 ^@ http://purl.uniprot.org/uniprot/M3W5J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9685:N6AMT1 ^@ http://purl.uniprot.org/uniprot/A0A337S4T8 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/9685:LOC101093269 ^@ http://purl.uniprot.org/uniprot/M3XAW8 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:LOC101099668 ^@ http://purl.uniprot.org/uniprot/A0A5F5XLY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/A0A337SFL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/9685:IPO7 ^@ http://purl.uniprot.org/uniprot/M3XA23 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:GGTA1 ^@ http://purl.uniprot.org/uniprot/Q8HY56 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Binds 1 Mn(2+) ion per subunit.|||Golgi stack membrane|||Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isogloboside 3 (iGb3) (By similarity).|||The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity). http://togogenome.org/gene/9685:SSBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3I8 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9685:ID1 ^@ http://purl.uniprot.org/uniprot/M3W2G6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:REEP4 ^@ http://purl.uniprot.org/uniprot/A0A337SGD3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:STC2 ^@ http://purl.uniprot.org/uniprot/M3WZL4 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9685:TLX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0H0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101082972 ^@ http://purl.uniprot.org/uniprot/A0A5F5XIN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NELL2 ^@ http://purl.uniprot.org/uniprot/M3WPC8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:GOLM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UII2|||http://purl.uniprot.org/uniprot/M3WMY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9685:NID1 ^@ http://purl.uniprot.org/uniprot/M3WED3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9685:IL33 ^@ http://purl.uniprot.org/uniprot/M3WAQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9685:EIF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEV3 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9685:LOC101089798 ^@ http://purl.uniprot.org/uniprot/M3X8A1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ARG1 ^@ http://purl.uniprot.org/uniprot/M3VXU3 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9685:PLD4 ^@ http://purl.uniprot.org/uniprot/M3WEG9 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9685:CTLA4 ^@ http://purl.uniprot.org/uniprot/Q9XTA1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9685:SIAH1 ^@ http://purl.uniprot.org/uniprot/M3WEX6 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9685:LOC101090648 ^@ http://purl.uniprot.org/uniprot/M3X150 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CAVIN2 ^@ http://purl.uniprot.org/uniprot/M3XCQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9685:TSEN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UT31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9685:LOC101089391 ^@ http://purl.uniprot.org/uniprot/M3XDC1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GRIN2A ^@ http://purl.uniprot.org/uniprot/M3WKG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9685:CLDN2 ^@ http://purl.uniprot.org/uniprot/M3WL24 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:CD53 ^@ http://purl.uniprot.org/uniprot/M3W8H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:CLDN3 ^@ http://purl.uniprot.org/uniprot/A0A337S9C9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:RPL12 ^@ http://purl.uniprot.org/uniprot/M3WD17 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9685:ETV1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4K0|||http://purl.uniprot.org/uniprot/A0A337SLA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:SMAD4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:HSPB8 ^@ http://purl.uniprot.org/uniprot/M3XDU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity.|||Nucleus http://togogenome.org/gene/9685:RBP5 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3N2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9685:KCNMB4 ^@ http://purl.uniprot.org/uniprot/M3X6G9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9685:GNAL ^@ http://purl.uniprot.org/uniprot/M3XAG1 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/9685:MAPK4 ^@ http://purl.uniprot.org/uniprot/M3WGF3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9685:GK ^@ http://purl.uniprot.org/uniprot/A0A337SSR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9685:ZC3HC1 ^@ http://purl.uniprot.org/uniprot/M3WD88 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:WAS ^@ http://purl.uniprot.org/uniprot/M3WNI4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:BCDIN3D ^@ http://purl.uniprot.org/uniprot/M3WBG8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9685:SMARCD3 ^@ http://purl.uniprot.org/uniprot/A0A337SWI9 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/9685:HYOU1 ^@ http://purl.uniprot.org/uniprot/M3VW30 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9685:LOC101094779 ^@ http://purl.uniprot.org/uniprot/M3X7P2 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:LOC101089059 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9685:UCN3 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6R5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9685:EHD1 ^@ http://purl.uniprot.org/uniprot/M3X1U0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9685:CHRDL1 ^@ http://purl.uniprot.org/uniprot/A0A337SXT7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9685:LOC101083890 ^@ http://purl.uniprot.org/uniprot/A0A337SNC8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:LOC101095096 ^@ http://purl.uniprot.org/uniprot/M3WJ28 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:DYRK3 ^@ http://purl.uniprot.org/uniprot/M3XF30 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9685:LOC101085238 ^@ http://purl.uniprot.org/uniprot/M3XFG9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CRELD2 ^@ http://purl.uniprot.org/uniprot/M3WQ40 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:GABRA4 ^@ http://purl.uniprot.org/uniprot/M3WNN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:LOC102901287 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:SMIM15 ^@ http://purl.uniprot.org/uniprot/M3X2G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9685:UCP3 ^@ http://purl.uniprot.org/uniprot/M3W3C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:FAM83B ^@ http://purl.uniprot.org/uniprot/M3WIV0 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9685:STAT6 ^@ http://purl.uniprot.org/uniprot/M3WKY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:XIRP1 ^@ http://purl.uniprot.org/uniprot/M3WYH4 ^@ Domain|||Function|||Similarity ^@ Belongs to the Xin family.|||Protects actin filaments from depolymerization.|||Xin repeats bind F-actin. http://togogenome.org/gene/9685:CD34 ^@ http://purl.uniprot.org/uniprot/Q8HZ47 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PRMT5 ^@ http://purl.uniprot.org/uniprot/M3W690 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:YKT6 ^@ http://purl.uniprot.org/uniprot/M3WKK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9685:TUBB6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9685:GPC6 ^@ http://purl.uniprot.org/uniprot/M3X6B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9685:CASR ^@ http://purl.uniprot.org/uniprot/C7FF08|||http://purl.uniprot.org/uniprot/M3WA39 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:WNK3 ^@ http://purl.uniprot.org/uniprot/M3W523 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9685:TLR3 ^@ http://purl.uniprot.org/uniprot/A0ENH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9685:MYOZ2 ^@ http://purl.uniprot.org/uniprot/M3VZJ8 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9685:RRP15 ^@ http://purl.uniprot.org/uniprot/M3X3T5 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/9685:CCL20 ^@ http://purl.uniprot.org/uniprot/M3W0B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:CYP27B1 ^@ http://purl.uniprot.org/uniprot/M3WL64 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9685:H1-4 ^@ http://purl.uniprot.org/uniprot/A0A5F5XKM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9685:CREB5 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULB1|||http://purl.uniprot.org/uniprot/A0A2I2UYM1|||http://purl.uniprot.org/uniprot/M3WN95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.|||Binds to the cAMP response element and activates transcription.|||Nucleus http://togogenome.org/gene/9685:TRAF5 ^@ http://purl.uniprot.org/uniprot/A0A2I2U801|||http://purl.uniprot.org/uniprot/M3VXY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9685:SNX20 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Membrane http://togogenome.org/gene/9685:TAS1R3 ^@ http://purl.uniprot.org/uniprot/Q49KI5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.|||Cell membrane|||Expressed in taste buds.|||Forms homodimers or a heterodimer with TAS1R1.|||Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) (By similarity).|||Unlike most mammals domestic cats do not prefer and are unable to detect the sweetness of sugars. This is due to pseudogenization of the TAS1R2 gene which prevents the formation of the heterodimeric sweet taste receptor TAS1R2/TAS1R3. This molecular change was very likely an important event in the evolution of the cat's carnivorous behavior. http://togogenome.org/gene/9685:ASZ1 ^@ http://purl.uniprot.org/uniprot/A0M8T3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). http://togogenome.org/gene/9685:PGC ^@ http://purl.uniprot.org/uniprot/M3WL88 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9685:LOC101084275 ^@ http://purl.uniprot.org/uniprot/M3X7D1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ATP6V1A ^@ http://purl.uniprot.org/uniprot/M3X6U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Vesicle|||clathrin-coated vesicle membrane|||secretory vesicle http://togogenome.org/gene/9685:POLR2G ^@ http://purl.uniprot.org/uniprot/M3X707 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9685:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A337S3J3|||http://purl.uniprot.org/uniprot/A0A337SH57|||http://purl.uniprot.org/uniprot/M3W7J0 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/9685:DAPK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQ18|||http://purl.uniprot.org/uniprot/M3W1Q1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:EARS2 ^@ http://purl.uniprot.org/uniprot/M3X6Q0 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/9685:MPP7 ^@ http://purl.uniprot.org/uniprot/A0A5F5XJ14|||http://purl.uniprot.org/uniprot/M3WAD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||adherens junction|||tight junction http://togogenome.org/gene/9685:KCNMB3 ^@ http://purl.uniprot.org/uniprot/A0A337SF69 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9685:SLC52A3 ^@ http://purl.uniprot.org/uniprot/M3WE72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9685:CASP4 ^@ http://purl.uniprot.org/uniprot/Q9MZV6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C14A family.|||Cell membrane|||Cytoplasm|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit.|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NLRP2 and whose function would be the activation of pro-inflammatory caspases. Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis). Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17P/INCA and CARD18. Interacts with SERPINB1; this interaction regulates CASP1 activity.|||The two subunits are derived from the precursor sequence by an autocatalytic mechanism.|||Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.|||Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8. http://togogenome.org/gene/9685:CAV1 ^@ http://purl.uniprot.org/uniprot/A0M8S7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).|||May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).|||Membrane raft|||Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.|||Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.|||caveola http://togogenome.org/gene/9685:RAB11FIP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2US40 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||Endosome membrane|||Membrane|||Midbody|||Recycling endosome membrane http://togogenome.org/gene/9685:TFF3 ^@ http://purl.uniprot.org/uniprot/B4X8D9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) (By similarity).|||Monomer. Homodimer; disulfide-linked.|||extracellular matrix http://togogenome.org/gene/9685:RPS6KB1 ^@ http://purl.uniprot.org/uniprot/A0A337SNA8|||http://purl.uniprot.org/uniprot/M3X5V6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9685:SHMT1 ^@ http://purl.uniprot.org/uniprot/M3WMK4 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9685:SLC9A6 ^@ http://purl.uniprot.org/uniprot/A0A5F5XQH5|||http://purl.uniprot.org/uniprot/M3WII7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9685:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A337S4S0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9685:LOC101081992 ^@ http://purl.uniprot.org/uniprot/M3WIX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9685:TMED3 ^@ http://purl.uniprot.org/uniprot/A0A337SAE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9685:SPEM2 ^@ http://purl.uniprot.org/uniprot/M3WH76 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101081645 ^@ http://purl.uniprot.org/uniprot/M3X8V9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101087741 ^@ http://purl.uniprot.org/uniprot/M3WSW5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:FELCATV1R15 ^@ http://purl.uniprot.org/uniprot/A0A0A0Y7K9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:LIPA ^@ http://purl.uniprot.org/uniprot/A0A5F5XPV2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9685:NDRG4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U6L6|||http://purl.uniprot.org/uniprot/M3W665 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9685:CDH9 ^@ http://purl.uniprot.org/uniprot/M3X7B9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:FELCATV1R4 ^@ http://purl.uniprot.org/uniprot/A0A5F5XUT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:MSRA ^@ http://purl.uniprot.org/uniprot/A0A5F5Y0Z9 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/9685:FLOT1 ^@ http://purl.uniprot.org/uniprot/M3W869 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||Membrane|||caveola http://togogenome.org/gene/9685:TOP3A ^@ http://purl.uniprot.org/uniprot/A0A2I2UBY3|||http://purl.uniprot.org/uniprot/A0A5F5XQM6 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9685:PLIN5 ^@ http://purl.uniprot.org/uniprot/M3WPA9 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/9685:CHPF2 ^@ http://purl.uniprot.org/uniprot/M3WIF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9685:HDHD3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XRE7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9685:CASP9 ^@ http://purl.uniprot.org/uniprot/A0A337SNV2|||http://purl.uniprot.org/uniprot/M3WUW6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9685:TRABD2A ^@ http://purl.uniprot.org/uniprot/M3VVD4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIKI family.|||Cell membrane|||Divalent metal cations. Mn(2+) or Co(2+).|||Membrane|||Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. http://togogenome.org/gene/9685:GNL2 ^@ http://purl.uniprot.org/uniprot/M3WA66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/9685:LOC101098177 ^@ http://purl.uniprot.org/uniprot/M3XEY2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:STX6 ^@ http://purl.uniprot.org/uniprot/M3WFX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9685:YTHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBC0 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9685:NCAPH ^@ http://purl.uniprot.org/uniprot/A0A2I2UVW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/9685:NTN4 ^@ http://purl.uniprot.org/uniprot/A0A337S1P0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:BORCS8 ^@ http://purl.uniprot.org/uniprot/A0A337SIF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9685:KCNA6 ^@ http://purl.uniprot.org/uniprot/M3VYC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:EGFLAM ^@ http://purl.uniprot.org/uniprot/A0A2I2UEP2|||http://purl.uniprot.org/uniprot/M3WDB8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:RBM15 ^@ http://purl.uniprot.org/uniprot/M3XCA7 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/9685:SIX1 ^@ http://purl.uniprot.org/uniprot/M3XF50 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:GAD2 ^@ http://purl.uniprot.org/uniprot/M3VYC1 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9685:CEPT1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XIU7|||http://purl.uniprot.org/uniprot/M3WCQ1 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9685:PIK3IP1 ^@ http://purl.uniprot.org/uniprot/M3VWF4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SLC35E4 ^@ http://purl.uniprot.org/uniprot/M3W1K1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V5I2 ^@ Cofactor ^@ Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9685:ATP2B4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVB8|||http://purl.uniprot.org/uniprot/A0A2I2V0M6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:GBA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCJ0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/9685:MYF5 ^@ http://purl.uniprot.org/uniprot/M3WLS2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9685:PRKAB1 ^@ http://purl.uniprot.org/uniprot/M3VVN1 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9685:ABCD1 ^@ http://purl.uniprot.org/uniprot/M3W1G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9685:UBE3D ^@ http://purl.uniprot.org/uniprot/A0A2I2UAH8|||http://purl.uniprot.org/uniprot/M3WDJ3 ^@ Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. http://togogenome.org/gene/9685:CCNH ^@ http://purl.uniprot.org/uniprot/M3W2X6 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family. Cyclin C subfamily.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/9685:THRA ^@ http://purl.uniprot.org/uniprot/A0A2I2UWD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9685:ATP5PO ^@ http://purl.uniprot.org/uniprot/M3WSZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:SNRNP27 ^@ http://purl.uniprot.org/uniprot/M3WYQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/9685:PDPK1 ^@ http://purl.uniprot.org/uniprot/A0A337SBQ1|||http://purl.uniprot.org/uniprot/M3VXM6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/9685:CALCB ^@ http://purl.uniprot.org/uniprot/A0A2I2UK40 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9685:MFSD6 ^@ http://purl.uniprot.org/uniprot/M3W3M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/9685:GNPDA1 ^@ http://purl.uniprot.org/uniprot/M3WBD4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9685:PKNOX2 ^@ http://purl.uniprot.org/uniprot/M3WLX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9685:HASPIN ^@ http://purl.uniprot.org/uniprot/M3X5G0 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9685:CCNY ^@ http://purl.uniprot.org/uniprot/M3XBP5 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9685:VPS51 ^@ http://purl.uniprot.org/uniprot/M3W5J8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS51 family.|||Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.|||Endosome|||Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/9685:COL4A6 ^@ http://purl.uniprot.org/uniprot/A0A337SDB4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9685:MRPL12 ^@ http://purl.uniprot.org/uniprot/M3WHW8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/9685:IL6ST ^@ http://purl.uniprot.org/uniprot/M3WE28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9685:POLA2 ^@ http://purl.uniprot.org/uniprot/M3VWM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/9685:STEAP2 ^@ http://purl.uniprot.org/uniprot/M3WNS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9685:TMEM135 ^@ http://purl.uniprot.org/uniprot/M3X3Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane http://togogenome.org/gene/9685:DOP1A ^@ http://purl.uniprot.org/uniprot/A0A2I2U9V7|||http://purl.uniprot.org/uniprot/A0A2I2UM74|||http://purl.uniprot.org/uniprot/M3W4K2 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/9685:MFSD11 ^@ http://purl.uniprot.org/uniprot/M3W1T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9685:UTS2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y2K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/9685:SLC46A1 ^@ http://purl.uniprot.org/uniprot/M3W9I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:HNRNPA3 ^@ http://purl.uniprot.org/uniprot/M3WGE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:HSD17B3 ^@ http://purl.uniprot.org/uniprot/M3VZ12 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:TMEM115 ^@ http://purl.uniprot.org/uniprot/M3WT82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:SDC2 ^@ http://purl.uniprot.org/uniprot/M3WXE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9685:BMPR2 ^@ http://purl.uniprot.org/uniprot/M3WK25 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/9685:TMEM184A ^@ http://purl.uniprot.org/uniprot/M3WP43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:MECOM ^@ http://purl.uniprot.org/uniprot/A0A2I2UNB9|||http://purl.uniprot.org/uniprot/A0A337SBC4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SORD ^@ http://purl.uniprot.org/uniprot/A0A2I2V1M2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Binds 1 or 2 Zn(2+) ions per subunit.|||Homotetramer.|||Mitochondrion membrane|||Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.|||flagellum http://togogenome.org/gene/9685:RCL1 ^@ http://purl.uniprot.org/uniprot/M3WKX1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/9685:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/M3WX35 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9685:CCDC103 ^@ http://purl.uniprot.org/uniprot/M3WPN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/9685:ADRB3 ^@ http://purl.uniprot.org/uniprot/Q9TST4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis (By similarity).|||Cell membrane|||Interacts with ARRDC3. http://togogenome.org/gene/9685:ST14 ^@ http://purl.uniprot.org/uniprot/M3WBJ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S1 family.|||Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.|||Interacts with CDCP1. May interact with TMEFF1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:SLC4A2 ^@ http://purl.uniprot.org/uniprot/A0A337SQX2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:GPR89A ^@ http://purl.uniprot.org/uniprot/A0A5F5XCN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/9685:ATP5F1A ^@ http://purl.uniprot.org/uniprot/M3WZB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9685:EML2 ^@ http://purl.uniprot.org/uniprot/M3X7H8 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9685:HMGB1 ^@ http://purl.uniprot.org/uniprot/M3VUA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/9685:GPR55 ^@ http://purl.uniprot.org/uniprot/M3XD37 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:DOCK4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVR6|||http://purl.uniprot.org/uniprot/M3WHB8 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9685:FAM131C ^@ http://purl.uniprot.org/uniprot/A0A5F5XJX2 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/9685:CKAP2 ^@ http://purl.uniprot.org/uniprot/M3WCK0 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/9685:TM2D3 ^@ http://purl.uniprot.org/uniprot/M3X295 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC102899397 ^@ http://purl.uniprot.org/uniprot/A0A5F5XMJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9685:ARFGEF1 ^@ http://purl.uniprot.org/uniprot/M3WMT3 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9685:LOC105261012 ^@ http://purl.uniprot.org/uniprot/A0A5F5XH25 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SHBG ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6V8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CENPN ^@ http://purl.uniprot.org/uniprot/A0A5F5XWD3 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/9685:EAF2 ^@ http://purl.uniprot.org/uniprot/M3WP25 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/9685:TYR ^@ http://purl.uniprot.org/uniprot/P55033 ^@ Cofactor|||Function|||PTM|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allelic variations in TYR may be associated with coat color phenotype in siamese and burmese cats. The coat color trait is autosomal recessive.|||Belongs to the tyrosinase family.|||Binds 2 copper ions per subunit.|||Forms an OPN3-dependent complex with DCT in response to blue light in melanocytes.|||Glycosylated.|||Melanosome|||Melanosome membrane|||This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity). http://togogenome.org/gene/9685:MRPL4 ^@ http://purl.uniprot.org/uniprot/A0A5F5XS96 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/9685:SNRPD3 ^@ http://purl.uniprot.org/uniprot/A0A337SKF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.|||cytosol http://togogenome.org/gene/9685:TTC26 ^@ http://purl.uniprot.org/uniprot/A0A337S733 ^@ Similarity ^@ Belongs to the IFT56 family. http://togogenome.org/gene/9685:LOC109494610 ^@ http://purl.uniprot.org/uniprot/A0A2I2UP33 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9685:TIGD4 ^@ http://purl.uniprot.org/uniprot/M3WPY0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:COX16 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:BPNT1 ^@ http://purl.uniprot.org/uniprot/M3XEI7 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9685:COPB2 ^@ http://purl.uniprot.org/uniprot/M3VWP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/9685:DDAH2 ^@ http://purl.uniprot.org/uniprot/M3XC02 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9685:FAM163A ^@ http://purl.uniprot.org/uniprot/M3X6B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9685:TLCD3B ^@ http://purl.uniprot.org/uniprot/M3WK74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TOM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UP45 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9685:MRPL28 ^@ http://purl.uniprot.org/uniprot/A0A337SG39 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/9685:LOC101094572 ^@ http://purl.uniprot.org/uniprot/M3X1H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:MRPL33 ^@ http://purl.uniprot.org/uniprot/A0A2I2UI79 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/9685:MFSD4B ^@ http://purl.uniprot.org/uniprot/A0A337SLE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ARHGAP26 ^@ http://purl.uniprot.org/uniprot/A0A5F5XD76|||http://purl.uniprot.org/uniprot/A0A5F5Y3T2|||http://purl.uniprot.org/uniprot/M3WAU9 ^@ Subcellular Location Annotation ^@ cytoskeleton|||focal adhesion http://togogenome.org/gene/9685:LPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UV17 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9685:GART ^@ http://purl.uniprot.org/uniprot/M3WB84 ^@ Similarity ^@ In the C-terminal section; belongs to the GART family.|||In the N-terminal section; belongs to the GARS family.|||In the central section; belongs to the AIR synthase family. http://togogenome.org/gene/9685:FBP2 ^@ http://purl.uniprot.org/uniprot/M3VXP7 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9685:LOC101080258 ^@ http://purl.uniprot.org/uniprot/M3X9R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:FXN ^@ http://purl.uniprot.org/uniprot/M3X7T9 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/9685:RPL41 ^@ http://purl.uniprot.org/uniprot/P62946 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL41 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity). Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII (By similarity).|||Cytoplasm http://togogenome.org/gene/9685:MZF1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6Z6|||http://purl.uniprot.org/uniprot/M3W0X0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:COX18 ^@ http://purl.uniprot.org/uniprot/M3WJS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9685:TEKT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UI14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9685:GABRA3 ^@ http://purl.uniprot.org/uniprot/M3WNK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:CUL4B ^@ http://purl.uniprot.org/uniprot/A0A2I2U2R4|||http://purl.uniprot.org/uniprot/A0A337SMN1|||http://purl.uniprot.org/uniprot/Q1WF15 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9685:CPNE9 ^@ http://purl.uniprot.org/uniprot/M3WP11 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9685:STX4 ^@ http://purl.uniprot.org/uniprot/M3X2Z0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9685:CCL5 ^@ http://purl.uniprot.org/uniprot/Q8SQ40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.|||Secreted http://togogenome.org/gene/9685:SST ^@ http://purl.uniprot.org/uniprot/M3W6D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9685:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/M3W1P8 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9685:HYAL3 ^@ http://purl.uniprot.org/uniprot/A0A337RZA8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9685:BCL2 ^@ http://purl.uniprot.org/uniprot/Q8I008 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion outer membrane|||Nucleus membrane http://togogenome.org/gene/9685:ZNF280C ^@ http://purl.uniprot.org/uniprot/M3WPH8 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9685:CASK ^@ http://purl.uniprot.org/uniprot/A0A2I2UBK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane http://togogenome.org/gene/9685:LOC101098399 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7I6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:RBM5 ^@ http://purl.uniprot.org/uniprot/M3WL23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/9685:SNX11 ^@ http://purl.uniprot.org/uniprot/M3WBA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9685:MYG1 ^@ http://purl.uniprot.org/uniprot/A0A337S6B3 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/9685:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A337RYV5|||http://purl.uniprot.org/uniprot/A0A337SIU8 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/9685:TNP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 1 family.|||Chromosome|||Nucleus http://togogenome.org/gene/9685:GLYCTK ^@ http://purl.uniprot.org/uniprot/M3WN46 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9685:SLC47A1 ^@ http://purl.uniprot.org/uniprot/M3WFX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/9685:POLE2 ^@ http://purl.uniprot.org/uniprot/M3WAU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus|||Participates in DNA repair and in chromosomal DNA replication. http://togogenome.org/gene/9685:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/M3VWL7 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/9685:PIGB ^@ http://purl.uniprot.org/uniprot/M3XDS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:MUS81 ^@ http://purl.uniprot.org/uniprot/A0A5F5XRX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/9685:SLCO5A1 ^@ http://purl.uniprot.org/uniprot/M3X4E9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:SPICE1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3E8 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CEP120.|||centriole|||spindle http://togogenome.org/gene/9685:ADAM9 ^@ http://purl.uniprot.org/uniprot/M3VYT3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LOC101087010 ^@ http://purl.uniprot.org/uniprot/M3WFP7 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9685:FAM187A ^@ http://purl.uniprot.org/uniprot/M3W442 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9685:TMEM17 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:DDX56 ^@ http://purl.uniprot.org/uniprot/M3WCY9 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9685:CASP8 ^@ http://purl.uniprot.org/uniprot/A0A5F5XMX6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9685:SLC35A2 ^@ http://purl.uniprot.org/uniprot/M3VYR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:TOMM5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:GRWD1 ^@ http://purl.uniprot.org/uniprot/M3VXX5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:HTRA2 ^@ http://purl.uniprot.org/uniprot/M3W782 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/9685:SRP72 ^@ http://purl.uniprot.org/uniprot/M3X9Y0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/9685:ZNF24 ^@ http://purl.uniprot.org/uniprot/A0A2I2U772 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PIGG ^@ http://purl.uniprot.org/uniprot/M3W965 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:FABP1 ^@ http://purl.uniprot.org/uniprot/M3WR74 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/9685:KCNK10 ^@ http://purl.uniprot.org/uniprot/M3VWM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9685:RPL24 ^@ http://purl.uniprot.org/uniprot/Q66WF5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Mono-ADP-ribosylation at Glu-4 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation. http://togogenome.org/gene/9685:PTP4A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKX7 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9685:LOC101098354 ^@ http://purl.uniprot.org/uniprot/M3X164 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A2I2UCF5|||http://purl.uniprot.org/uniprot/A0A337S4F5|||http://purl.uniprot.org/uniprot/A0A337SMM9|||http://purl.uniprot.org/uniprot/A0A5F5XU46|||http://purl.uniprot.org/uniprot/A0A5F5Y385|||http://purl.uniprot.org/uniprot/M3WNF0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9685:PLSCR5 ^@ http://purl.uniprot.org/uniprot/M3XDI5 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9685:AKAP5 ^@ http://purl.uniprot.org/uniprot/M3X394 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101098931 ^@ http://purl.uniprot.org/uniprot/M3WSR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101086986 ^@ http://purl.uniprot.org/uniprot/A0A337S8F5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101096427 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6X9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:RARA ^@ http://purl.uniprot.org/uniprot/A0A2I2USN5|||http://purl.uniprot.org/uniprot/M3WWH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9685:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTY2 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9685:LIN52 ^@ http://purl.uniprot.org/uniprot/A0A337SHP8 ^@ Similarity ^@ Belongs to the lin-52 family. http://togogenome.org/gene/9685:LOC101098601 ^@ http://purl.uniprot.org/uniprot/M3XAE0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:AMPD3 ^@ http://purl.uniprot.org/uniprot/M3VUP4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9685:CSRNP2 ^@ http://purl.uniprot.org/uniprot/M3W246 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9685:POMT1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZ91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/9685:CE3H16orf91 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBE3 ^@ Similarity ^@ Belongs to the UQCC4 family. http://togogenome.org/gene/9685:VPS8 ^@ http://purl.uniprot.org/uniprot/M3W8E7 ^@ Similarity ^@ Belongs to the VPS8 family. http://togogenome.org/gene/9685:FBN2 ^@ http://purl.uniprot.org/uniprot/M3WBW4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9685:NOP14 ^@ http://purl.uniprot.org/uniprot/M3W2I0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/9685:PRKCD ^@ http://purl.uniprot.org/uniprot/M3W161 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9685:LOC101097564 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9685:RFTN2 ^@ http://purl.uniprot.org/uniprot/M3X6L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PCNA ^@ http://purl.uniprot.org/uniprot/M3WAR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9685:RIOX2 ^@ http://purl.uniprot.org/uniprot/M3W7I7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family. MINA53 subfamily.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. http://togogenome.org/gene/9685:C4BPB ^@ http://purl.uniprot.org/uniprot/M3WJK2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:MIPEP ^@ http://purl.uniprot.org/uniprot/M3WC78 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9685:POLR3C ^@ http://purl.uniprot.org/uniprot/A0A337SJQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9685:POLB ^@ http://purl.uniprot.org/uniprot/M3XC91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9685:SRPRA ^@ http://purl.uniprot.org/uniprot/A0A2I2UWH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:FAM91A1 ^@ http://purl.uniprot.org/uniprot/M3WDC0 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/9685:TOMM20 ^@ http://purl.uniprot.org/uniprot/M3X685 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:KCNE1 ^@ http://purl.uniprot.org/uniprot/Q9XSP1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).|||Apical cell membrane|||Belongs to the potassium channel KCNE family.|||Cell membrane|||Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex KCNQ1-KCNE1 to the membrane raft (By similarity).|||Membrane raft|||N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.|||Phosphorylation inhibits the potassium current. http://togogenome.org/gene/9685:TP53 ^@ http://purl.uniprot.org/uniprot/A0A059UCX8|||http://purl.uniprot.org/uniprot/P41685 ^@ Cofactor|||Disease Annotation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of Lys-375 by CREBBP enhances transcriptional activity. Acetylation of Lys-375 by EP300. Deacetylation of Lys-375 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-374 increases stability. Deacetylation at Lys-374 by SIRT6 decreases its stability, thereby regulating cell senescence.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-375) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest (By similarity). Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and COP1. Interacts with CCAR2 (via N-terminus). Interacts with MORC3. Interacts (via C-terminus) with POU4F2 (via C-terminus). Interacts (via oligomerization region) with NOP53; the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of TP53. Interacts with AFG1L; mediates mitochondrial translocation of TP53. Interacts with UBD (By similarity). Interacts with TAF6 (By similarity). Interacts with C10orf90/FATS; the interaction inhibits binding of TP53 and MDM2 (By similarity). Interacts with NUPR1; interaction is stress-dependent. Forms a complex with EP300 and NUPR1; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Interacts with PRMT5 in response to DNA damage; the interaction is TTC5/STRAP dependent (By similarity). Interacts with PPP1R13L (via SH3 domain and ANK repeats); the interaction inhibits pro-apoptotic activity of p53/TP53 (By similarity). Interacts with PPP1R13B/ASPP1 and TP53BP2/ASPP2; the interactions promotes pro-apoptotic activity (By similarity). When phosphorylated at Ser-15, interacts with DDX3X and gamma-tubulin (By similarity). Interacts with KAT7/HBO1; leading to inhibit histone acetyltransferase activity of KAT7/HBO1 (By similarity). Interacts with S100A4; this interaction promotes TP53 degradation (By similarity). Interacts with TTC5/STRAP; the interaction may result in increased mitochondrial-dependent apoptosis (By similarity). Interacts with NQO1; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (By similarity). Interacts with DAZAP2 at TP53 target gene promoters; the interaction is triggered by DNA damage and leads to modulation of the expression of a subset of TP53 target genes, reducing DNA damage-induced cell death by limiting the expression of cell death-mediating TP53 target genes (By similarity). Interacts (via N-terminus) with ZNF768 (via zinc-finger domains); interaction might be facilitated by TP53 oligomerization state (By similarity). Forms a ternary complex with ALDOB and G6PD; this interaction is direct. ALDOB stabilizes the complex inhibiting G6PD activity and keeping oxidative pentose phosphate metabolism in check. Interacts with MORN3; the interactions mediate post-transcriptional modifications of TP53 by MDM2 and SIRT1 (By similarity).|||Mitochondrion matrix|||Monomethylated at Lys-365 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-363 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-365 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-363. Dimethylated at Lys-366 by EHMT1 and EHMT2. Monomethylated at Lys-375 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-363 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-326 and dimethylated at Arg-328 and Arg-330 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).|||Nucleus|||PML body|||Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-385 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-385 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).|||Sumoylated with SUMO1. Sumoylated at Lys-379 by UBC9 (By similarity).|||The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.|||Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity).|||centrosome|||p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer. http://togogenome.org/gene/9685:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/M3WX55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:MID1IP1 ^@ http://purl.uniprot.org/uniprot/M3W296 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:VASP ^@ http://purl.uniprot.org/uniprot/M3W7Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||cytoskeleton http://togogenome.org/gene/9685:MYOC ^@ http://purl.uniprot.org/uniprot/Q594P2 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Cell projection|||Cytoplasmic vesicle|||Endoplasmic reticulum|||Expressed in optic nerve head, ciliary body and retina.|||Glycosylated.|||Golgi apparatus|||Homodimer (via N-terminus). Can also form higher oligomers. Interacts with OLFM3, FN1, NRCAM, GLDN and NFASC. Interacts (via N-terminus) with MYL2. Interacts with SFRP1, FRZB, FZD7, FZD10, FZD1 and WIF1; regulates Wnt signaling (By similarity). Interacts with SNTA1; regulates muscle hypertrophy. Interacts with ERBB2 and ERBB3; activates ERBB2-ERBB3 signaling pathway. Interacts with SNCG; affects its secretion and its aggregation (By similarity).|||Mitochondrion|||Mitochondrion inner membrane|||Mitochondrion intermembrane space|||Mitochondrion outer membrane|||Palmitoylated.|||Rough endoplasmic reticulum|||Secreted|||Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.|||Undergoes a calcium-dependent proteolytic cleavage at Arg-212 by CAPN2 in the endoplasmic reticulum. The result is the production of two fragments, one of 35 kDa containing the C-terminal olfactomedin-like domain, and another of 20 kDa containing the N-terminal leucine zipper-like domain (By similarity).|||cilium|||extracellular exosome|||extracellular matrix|||extracellular space http://togogenome.org/gene/9685:NRP1 ^@ http://purl.uniprot.org/uniprot/M3W5I5 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:DEFB124 ^@ http://purl.uniprot.org/uniprot/M3WL33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9685:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/M3XCQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9685:HSPA5 ^@ http://purl.uniprot.org/uniprot/M3WFT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cell surface|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9685:HAUS1 ^@ http://purl.uniprot.org/uniprot/M3W0V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/9685:CHAC2 ^@ http://purl.uniprot.org/uniprot/M3X427 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9685:KCNC4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UI20|||http://purl.uniprot.org/uniprot/A0A337SEE6|||http://purl.uniprot.org/uniprot/M3W8W5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:KCNAB2 ^@ http://purl.uniprot.org/uniprot/A0A337SHY7|||http://purl.uniprot.org/uniprot/A0A337SQG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/9685:POLG ^@ http://purl.uniprot.org/uniprot/M3WHT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-A family.|||Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.|||Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|||mitochondrion nucleoid http://togogenome.org/gene/9685:CBFB ^@ http://purl.uniprot.org/uniprot/A0A077DAU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/9685:DDX1 ^@ http://purl.uniprot.org/uniprot/A0A337SJN2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule|||RNA helicase.|||The helicase domain is involved in the stimulation of RELA transcriptional activity. http://togogenome.org/gene/9685:PLBD1 ^@ http://purl.uniprot.org/uniprot/M3WDG7 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/9685:ARMC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0S1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:PARG ^@ http://purl.uniprot.org/uniprot/M3WEE8 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/9685:PALS2 ^@ http://purl.uniprot.org/uniprot/A0A337S363 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane http://togogenome.org/gene/9685:LOC101101118 ^@ http://purl.uniprot.org/uniprot/A0A337SC15 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/9685:SNCG ^@ http://purl.uniprot.org/uniprot/M3W8Q2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.|||spindle http://togogenome.org/gene/9685:VAPA ^@ http://purl.uniprot.org/uniprot/M3WR51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:ADCK2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XR47|||http://purl.uniprot.org/uniprot/M3X3T3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/9685:FAM174A ^@ http://purl.uniprot.org/uniprot/M3XFE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9685:TRIT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZ49 ^@ Function|||Similarity ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37. http://togogenome.org/gene/9685:LOC101089263 ^@ http://purl.uniprot.org/uniprot/M3W6H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9685:SSX2IP ^@ http://purl.uniprot.org/uniprot/M3WQ12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/9685:NPM1 ^@ http://purl.uniprot.org/uniprot/M3X673 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9685:FN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U011|||http://purl.uniprot.org/uniprot/A0A2I2UAM2|||http://purl.uniprot.org/uniprot/M3WB06 ^@ Function ^@ Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. http://togogenome.org/gene/9685:DTD2 ^@ http://purl.uniprot.org/uniprot/M3X539 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/9685:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A337SV17 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:SLC10A3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XRT6|||http://purl.uniprot.org/uniprot/M3XEG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9685:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:ZBED9 ^@ http://purl.uniprot.org/uniprot/M3X5J7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SPIC ^@ http://purl.uniprot.org/uniprot/A0A2I2UPH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:HIRIP3 ^@ http://purl.uniprot.org/uniprot/M3WK70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CDKL1 ^@ http://purl.uniprot.org/uniprot/M3WU63 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:LOC101089279 ^@ http://purl.uniprot.org/uniprot/M3WVT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TH ^@ http://purl.uniprot.org/uniprot/M3W6S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region|||synaptic vesicle http://togogenome.org/gene/9685:STARD3 ^@ http://purl.uniprot.org/uniprot/M3WCB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9685:ACO1 ^@ http://purl.uniprot.org/uniprot/M3VWD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9685:LOC101097169 ^@ http://purl.uniprot.org/uniprot/M3WSC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MADD ^@ http://purl.uniprot.org/uniprot/A0A2I2TZX4|||http://purl.uniprot.org/uniprot/A0A2I2U987|||http://purl.uniprot.org/uniprot/A0A5F5XII2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MADD family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9685:TUBG1 ^@ http://purl.uniprot.org/uniprot/A0A341ZMI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9685:GAPVD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UDN4|||http://purl.uniprot.org/uniprot/A0A337S6X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/9685:MAT1A ^@ http://purl.uniprot.org/uniprot/M3WFC1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9685:YPEL5 ^@ http://purl.uniprot.org/uniprot/M3WRV9 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9685:LOC101084856 ^@ http://purl.uniprot.org/uniprot/M3W659 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MAP3K13 ^@ http://purl.uniprot.org/uniprot/M3XGD4 ^@ Function|||Similarity ^@ Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9685:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/M3X7C4 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/9685:TTC9B ^@ http://purl.uniprot.org/uniprot/M3WGG9 ^@ Similarity ^@ Belongs to the TTC9 family. http://togogenome.org/gene/9685:SKAP1 ^@ http://purl.uniprot.org/uniprot/M3W2U6 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9685:GAP43 ^@ http://purl.uniprot.org/uniprot/Q6S9D9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Cell membrane|||Cytoplasm|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts (via IQ domain) with calmodulin (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).|||Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity).|||Perikaryon|||Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).|||axon|||dendrite|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/9685:BYSL ^@ http://purl.uniprot.org/uniprot/M3WUE3 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9685:GTF2I ^@ http://purl.uniprot.org/uniprot/A0A2I2U478|||http://purl.uniprot.org/uniprot/A0A2I2UQH5|||http://purl.uniprot.org/uniprot/A0A5F5Y4L6|||http://purl.uniprot.org/uniprot/M3VYU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:INHBA ^@ http://purl.uniprot.org/uniprot/Q6X2S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B Interacts with FST and FSTL3 (By similarity).|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins (By similarity).|||Secreted http://togogenome.org/gene/9685:ROM1 ^@ http://purl.uniprot.org/uniprot/M3WAC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9685:NOP16 ^@ http://purl.uniprot.org/uniprot/M3WSL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/9685:RGS5 ^@ http://purl.uniprot.org/uniprot/M3VZD1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/9685:MED17 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVT9|||http://purl.uniprot.org/uniprot/A0A337S6P6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:ARGLU1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U281 ^@ Similarity ^@ Belongs to the UPF0430 family. http://togogenome.org/gene/9685:SLC51A ^@ http://purl.uniprot.org/uniprot/M3W838 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/M3WY80 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/9685:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2USC9|||http://purl.uniprot.org/uniprot/M3W3P3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9685:EMC3 ^@ http://purl.uniprot.org/uniprot/M3WUY6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9685:POLH ^@ http://purl.uniprot.org/uniprot/M3WC09 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:VIRMA ^@ http://purl.uniprot.org/uniprot/A0A2I2UHJ3 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/9685:ITPR2 ^@ http://purl.uniprot.org/uniprot/M3W202 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/9685:KCND3 ^@ http://purl.uniprot.org/uniprot/M3VYX9 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/9685:DUOXA2 ^@ http://purl.uniprot.org/uniprot/M3W7X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9685:COQ7 ^@ http://purl.uniprot.org/uniprot/M3WJK9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:NPPB ^@ http://purl.uniprot.org/uniprot/Q9GLK4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3 (By similarity).|||Secreted|||The precursor molecule is proteolytically cleaved, possibly by FURIN or CORIN, to produce the active peptide (By similarity). May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity). May be cleaved at Ser-102 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity). May be degraded by IDE (By similarity). During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity). http://togogenome.org/gene/9685:POLR3GL ^@ http://purl.uniprot.org/uniprot/A0A2I2UT79|||http://purl.uniprot.org/uniprot/M3W407 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9685:SPIN4 ^@ http://purl.uniprot.org/uniprot/M3W190 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9685:CFL2 ^@ http://purl.uniprot.org/uniprot/M3W9N7 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9685:SPCS2 ^@ http://purl.uniprot.org/uniprot/M3WTL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS2 family.|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:MARS2 ^@ http://purl.uniprot.org/uniprot/M3XBX3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:CD2H10orf53 ^@ http://purl.uniprot.org/uniprot/M3X8J2 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9685:TAF6 ^@ http://purl.uniprot.org/uniprot/M3W0J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9685:CKS2 ^@ http://purl.uniprot.org/uniprot/M3WTJ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9685:CFDP1 ^@ http://purl.uniprot.org/uniprot/M3X5T0 ^@ Function|||Subcellular Location Annotation ^@ May play a role during embryogenesis.|||kinetochore http://togogenome.org/gene/9685:TRDMT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UB83 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/9685:ROMO1 ^@ http://purl.uniprot.org/uniprot/M3VZZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:CCR9 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9Q0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:PSMG2 ^@ http://purl.uniprot.org/uniprot/M3W4P4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/9685:BMS1 ^@ http://purl.uniprot.org/uniprot/M3WEP4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9685:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A337S784 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9685:PDE4D ^@ http://purl.uniprot.org/uniprot/A0A2I2UF71|||http://purl.uniprot.org/uniprot/A0A5F5XH54|||http://purl.uniprot.org/uniprot/A0A5F5XY00|||http://purl.uniprot.org/uniprot/M3X0T1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:TAGLN ^@ http://purl.uniprot.org/uniprot/M3WJ37 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9685:ENDOU ^@ http://purl.uniprot.org/uniprot/M3WJV9 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/9685:PREB ^@ http://purl.uniprot.org/uniprot/M3W3K4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/9685:CYP17A1 ^@ http://purl.uniprot.org/uniprot/Q9GMC8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Microsome membrane|||Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity. http://togogenome.org/gene/9685:TMEM43 ^@ http://purl.uniprot.org/uniprot/M3VXF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/9685:SAMM50 ^@ http://purl.uniprot.org/uniprot/M3W7J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9685:RARG ^@ http://purl.uniprot.org/uniprot/A0A2I2U5U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9685:AP1B1 ^@ http://purl.uniprot.org/uniprot/A0A337S3J7|||http://purl.uniprot.org/uniprot/M3WY66 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9685:F8 ^@ http://purl.uniprot.org/uniprot/A0A5F5XH53 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9685:KIF2C ^@ http://purl.uniprot.org/uniprot/A0A2I2US90|||http://purl.uniprot.org/uniprot/A0A337S7F1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:RAMP3 ^@ http://purl.uniprot.org/uniprot/A0A337RZ00 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/9685:BET1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UH39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A337RXB3|||http://purl.uniprot.org/uniprot/M3VU98 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9685:TOP2A ^@ http://purl.uniprot.org/uniprot/M3WBT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9685:SLC6A14 ^@ http://purl.uniprot.org/uniprot/M3XF00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9685:FGD1 ^@ http://purl.uniprot.org/uniprot/M3VY47 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:LOC101101025 ^@ http://purl.uniprot.org/uniprot/A0A5F5XJU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:NPR2 ^@ http://purl.uniprot.org/uniprot/M3WHI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9685:RPL35A ^@ http://purl.uniprot.org/uniprot/A0A337SK14 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/9685:DOK1 ^@ http://purl.uniprot.org/uniprot/M3W784 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9685:MTFMT ^@ http://purl.uniprot.org/uniprot/M3X767 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/9685:BRK1 ^@ http://purl.uniprot.org/uniprot/M3WEQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRK1 family.|||cytoskeleton http://togogenome.org/gene/9685:ECHDC2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XUV5|||http://purl.uniprot.org/uniprot/M3VXQ6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9685:FAM83A ^@ http://purl.uniprot.org/uniprot/A0A337RT72 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9685:UQCRC2 ^@ http://purl.uniprot.org/uniprot/M3W8B7 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9685:TGFBI ^@ http://purl.uniprot.org/uniprot/M3WKJ1 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9685:HHIPL2 ^@ http://purl.uniprot.org/uniprot/M3VY61 ^@ Similarity ^@ Belongs to the HHIP family. http://togogenome.org/gene/9685:LNPK ^@ http://purl.uniprot.org/uniprot/A0A2I2U439 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9685:SPO11 ^@ http://purl.uniprot.org/uniprot/M3VUQ4 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9685:GHRHR ^@ http://purl.uniprot.org/uniprot/M3VYQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:HNRNPF ^@ http://purl.uniprot.org/uniprot/M3XBR2 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9685:EIF5 ^@ http://purl.uniprot.org/uniprot/M3X5W9 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9685:LOC101099548 ^@ http://purl.uniprot.org/uniprot/M3W900 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9685:HOXB1 ^@ http://purl.uniprot.org/uniprot/M3X6P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9685:ASIP ^@ http://purl.uniprot.org/uniprot/A0A2I2UIB8|||http://purl.uniprot.org/uniprot/Q865F0 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).|||Secreted|||The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. http://togogenome.org/gene/9685:IL18R1 ^@ http://purl.uniprot.org/uniprot/Q6YBY1 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9685:CHST11 ^@ http://purl.uniprot.org/uniprot/A0A5F5XJQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:HOXC4 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9685:INPP5K ^@ http://purl.uniprot.org/uniprot/M3W5M3 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/9685:NMBR ^@ http://purl.uniprot.org/uniprot/M3XDP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LASP1 ^@ http://purl.uniprot.org/uniprot/M3X768 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9685:LOC101095127 ^@ http://purl.uniprot.org/uniprot/A0A5F5XLN4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:TRPM8 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y5X4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:SPATS2L ^@ http://purl.uniprot.org/uniprot/A0A5F5XN43 ^@ Similarity ^@ Belongs to the SPATS2 family. http://togogenome.org/gene/9685:GPR171 ^@ http://purl.uniprot.org/uniprot/M3XC60 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:CACYBP ^@ http://purl.uniprot.org/uniprot/M3W9V3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/9685:SMAD5 ^@ http://purl.uniprot.org/uniprot/M3X9P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:LOC105260418 ^@ http://purl.uniprot.org/uniprot/A0A337SK14 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/9685:ADCYAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U6R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9685:STX18 ^@ http://purl.uniprot.org/uniprot/M3XAH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Endoplasmic reticulum membrane|||Membrane|||Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. http://togogenome.org/gene/9685:A2ML1 ^@ http://purl.uniprot.org/uniprot/A0A337SNL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9685:PISD ^@ http://purl.uniprot.org/uniprot/A0A2I2UM52|||http://purl.uniprot.org/uniprot/A0A5F5Y004 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:SKP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9685:EHF ^@ http://purl.uniprot.org/uniprot/A0A2I2UPF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:GMPPA ^@ http://purl.uniprot.org/uniprot/M3WU81 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9685:ATP1B2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XVM0|||http://purl.uniprot.org/uniprot/A0A5F5Y2L4|||http://purl.uniprot.org/uniprot/M3WBS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9685:BDNF ^@ http://purl.uniprot.org/uniprot/Q9TST3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NGF-beta family.|||Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).|||Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.|||Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).|||Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2 (By similarity).|||N-glycosylated and glycosulfated, contrary to mature BDNF.|||Secreted http://togogenome.org/gene/9685:SNRPC ^@ http://purl.uniprot.org/uniprot/A0A337RWF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/9685:LOC101087322 ^@ http://purl.uniprot.org/uniprot/A0A5F5XMI9 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9685:TMEM39B ^@ http://purl.uniprot.org/uniprot/A0A5F5XYA9|||http://purl.uniprot.org/uniprot/M3VZL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9685:MRPS18A ^@ http://purl.uniprot.org/uniprot/A0A2I2UT60 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9685:LOC101091558 ^@ http://purl.uniprot.org/uniprot/M3WND9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues. http://togogenome.org/gene/9685:SEC13 ^@ http://purl.uniprot.org/uniprot/A0A337SC18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/9685:TSC22D1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVA2|||http://purl.uniprot.org/uniprot/M3WUL4 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9685:APMAP ^@ http://purl.uniprot.org/uniprot/M3X681 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/9685:GTF2H5 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8V6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/9685:NDUFA6 ^@ http://purl.uniprot.org/uniprot/M3WRH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101089699 ^@ http://purl.uniprot.org/uniprot/M3WXN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GRAMD1C ^@ http://purl.uniprot.org/uniprot/M3WWM4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:MMP15 ^@ http://purl.uniprot.org/uniprot/M3VYZ5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:PYGM ^@ http://purl.uniprot.org/uniprot/M3WGJ7 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9685:ELOVL6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWD2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/9685:CCL22 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:RANBP10 ^@ http://purl.uniprot.org/uniprot/B5LX41 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/9685:DRD3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XXG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.|||Membrane http://togogenome.org/gene/9685:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHJ1 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9685:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/M3W5S5 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9685:CLRN1 ^@ http://purl.uniprot.org/uniprot/M3WD68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9685:B3GALT2 ^@ http://purl.uniprot.org/uniprot/M3XBV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:GTF3C5 ^@ http://purl.uniprot.org/uniprot/M3W748 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ZNF165 ^@ http://purl.uniprot.org/uniprot/M3W0N3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/M3WIS8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/9685:ZRANB2 ^@ http://purl.uniprot.org/uniprot/A0A337SAN9|||http://purl.uniprot.org/uniprot/M3WWN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9685:PSMA6 ^@ http://purl.uniprot.org/uniprot/A0A337SVW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:LOC101084569 ^@ http://purl.uniprot.org/uniprot/M3X020 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CNR2 ^@ http://purl.uniprot.org/uniprot/M3WHU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:TMEM45B ^@ http://purl.uniprot.org/uniprot/A0A2I2U2P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9685:ARL4D ^@ http://purl.uniprot.org/uniprot/M3XEK4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9685:CAPZA2 ^@ http://purl.uniprot.org/uniprot/A0M8S9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity). http://togogenome.org/gene/9685:PSMC3 ^@ http://purl.uniprot.org/uniprot/A0A337SBG2 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9685:CPB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0Y4 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9685:APIP ^@ http://purl.uniprot.org/uniprot/M3VYQ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/9685:LCK ^@ http://purl.uniprot.org/uniprot/A0A2I2UG73|||http://purl.uniprot.org/uniprot/A0A2I2V1Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9685:CMKLR2 ^@ http://purl.uniprot.org/uniprot/M3WTW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LMBR1L ^@ http://purl.uniprot.org/uniprot/M3VU39 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9685:GLRA1 ^@ http://purl.uniprot.org/uniprot/M3WNZ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9685:RHPN2 ^@ http://purl.uniprot.org/uniprot/M3WLL2 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/9685:ATF7IP ^@ http://purl.uniprot.org/uniprot/M3WRU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9685:MRPL11 ^@ http://purl.uniprot.org/uniprot/M3X718 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9685:IER3IP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2USM4 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/9685:LOC101084226 ^@ http://purl.uniprot.org/uniprot/M3WQI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:BCKDK ^@ http://purl.uniprot.org/uniprot/A0A337SBB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9685:PRPF3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XYH3|||http://purl.uniprot.org/uniprot/M3WJS5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/9685:SMYHC ^@ http://purl.uniprot.org/uniprot/A0A5F5XV97|||http://purl.uniprot.org/uniprot/O97757 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||myofibril http://togogenome.org/gene/9685:GSG1L2 ^@ http://purl.uniprot.org/uniprot/M3WS61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9685:EPHA6 ^@ http://purl.uniprot.org/uniprot/A0A337SR05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101093799 ^@ http://purl.uniprot.org/uniprot/M3W5Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ESYT3 ^@ http://purl.uniprot.org/uniprot/M3WI11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:LOC101080913 ^@ http://purl.uniprot.org/uniprot/M3WEA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UA23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9685:EFNB2 ^@ http://purl.uniprot.org/uniprot/B0LDS5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:GPAT3 ^@ http://purl.uniprot.org/uniprot/A0A337SQ69 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9685:IMP4 ^@ http://purl.uniprot.org/uniprot/M3XDW6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9685:LOC101080615 ^@ http://purl.uniprot.org/uniprot/M3XCS3 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9685:DCLRE1B ^@ http://purl.uniprot.org/uniprot/A0A2I2UH02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9685:MAP3K12 ^@ http://purl.uniprot.org/uniprot/M3WHK7 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||May be an activator of the JNK/SAPK pathway. http://togogenome.org/gene/9685:HNRNPH2 ^@ http://purl.uniprot.org/uniprot/M3WMI8 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9685:PSMD12 ^@ http://purl.uniprot.org/uniprot/M3X366 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/9685:SPG21 ^@ http://purl.uniprot.org/uniprot/M3WF48 ^@ Function ^@ May play a role as a negative regulatory factor in CD4-dependent T-cell activation. http://togogenome.org/gene/9685:HS3ST5 ^@ http://purl.uniprot.org/uniprot/M3WSU2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9685:PRKCH ^@ http://purl.uniprot.org/uniprot/M3WHU4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation. http://togogenome.org/gene/9685:DST ^@ http://purl.uniprot.org/uniprot/M3XAY2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:GLYR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/9685:PTPN4 ^@ http://purl.uniprot.org/uniprot/M3XET0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9685:PIM1 ^@ http://purl.uniprot.org/uniprot/Q95LJ0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated (By similarity). Phosphorylated. Interaction with PPP2CA promotes dephosphorylation (By similarity).|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Cytoplasm|||Interacts with RP9 (By similarity). Interacts with HSP90AA1, this interaction stabilizes PIM1 protein levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteasomal degradation (By similarity).|||Nucleus|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 protein binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells. Promotes brown adipocyte differentiation.|||Ubiquitinated, leading to proteasomal degradation. http://togogenome.org/gene/9685:YWHAE ^@ http://purl.uniprot.org/uniprot/A0A337SCS9 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9685:MED1 ^@ http://purl.uniprot.org/uniprot/A0A337S891 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9685:TAF13 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHN0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:GPM6A ^@ http://purl.uniprot.org/uniprot/A0A337SPW9|||http://purl.uniprot.org/uniprot/M3X120 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9685:ST3GAL4 ^@ http://purl.uniprot.org/uniprot/A0A337S360 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:POLM ^@ http://purl.uniprot.org/uniprot/M3X1D8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).|||Nucleus http://togogenome.org/gene/9685:TMEM150A ^@ http://purl.uniprot.org/uniprot/M3XCC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A341ZMF7|||http://purl.uniprot.org/uniprot/M3VVX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:BBS2 ^@ http://purl.uniprot.org/uniprot/M3WA02 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9685:DNAL4 ^@ http://purl.uniprot.org/uniprot/A0A337S529 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9685:SGMS1 ^@ http://purl.uniprot.org/uniprot/M3WLS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9685:PPP2R5B ^@ http://purl.uniprot.org/uniprot/A0A5F5XG16 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9685:CRYBA2 ^@ http://purl.uniprot.org/uniprot/M3W7S8 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:SLC39A4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9685:CDK5 ^@ http://purl.uniprot.org/uniprot/M3X3E1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:MTFP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2H2 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/9685:HSPA9 ^@ http://purl.uniprot.org/uniprot/M3VX55 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9685:FAT4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCL3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CLCN5 ^@ http://purl.uniprot.org/uniprot/M3W9W9 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:LYRM2 ^@ http://purl.uniprot.org/uniprot/M3WAE7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9685:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A2I2USU9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.|||Cell membrane|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||cytoskeleton|||perinuclear region http://togogenome.org/gene/9685:SKA2 ^@ http://purl.uniprot.org/uniprot/M3X2R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA2 family.|||spindle http://togogenome.org/gene/9685:TIMM21 ^@ http://purl.uniprot.org/uniprot/M3X2F7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/9685:SLC30A4 ^@ http://purl.uniprot.org/uniprot/M3XB76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9685:GUSB ^@ http://purl.uniprot.org/uniprot/O97524 ^@ Activity Regulation|||Disease Annotation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Defects in GUSB are the cause of mucopolysaccharidosis type VII (MPS VII), an inherited disease reported in humans, mice, cats, and dogs.|||Homotetramer.|||Inhibited by L-aspartic acid.|||Lysosome|||Plays an important role in the degradation of dermatan and keratan sulfates. http://togogenome.org/gene/9685:AGTR2 ^@ http://purl.uniprot.org/uniprot/M3WK09 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/9685:BEST2 ^@ http://purl.uniprot.org/uniprot/M3VUU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9685:LOC101080269 ^@ http://purl.uniprot.org/uniprot/A0A337SE90|||http://purl.uniprot.org/uniprot/A0A337SIX3|||http://purl.uniprot.org/uniprot/M3WDI0 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9685:RARS1 ^@ http://purl.uniprot.org/uniprot/M3WRM0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:LOC101096518 ^@ http://purl.uniprot.org/uniprot/M3X813 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:AGBL3 ^@ http://purl.uniprot.org/uniprot/M3WUM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9685:ADCY7 ^@ http://purl.uniprot.org/uniprot/M3X5P3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9685:ANTXR1 ^@ http://purl.uniprot.org/uniprot/A0A337SQH5|||http://purl.uniprot.org/uniprot/M3W804 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9685:LRRC51 ^@ http://purl.uniprot.org/uniprot/M3W3V4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:CNPY1 ^@ http://purl.uniprot.org/uniprot/A0A337SBZ2 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9685:SLC18A3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XCI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PMPCB ^@ http://purl.uniprot.org/uniprot/M3VV49 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9685:HNMT ^@ http://purl.uniprot.org/uniprot/M3WWQ6 ^@ Function|||Subunit ^@ Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.|||Monomer. http://togogenome.org/gene/9685:SHKBP1 ^@ http://purl.uniprot.org/uniprot/M3VVW3 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/9685:GOLPH3L ^@ http://purl.uniprot.org/uniprot/A0A2I2UP52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9685:HBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XPK3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/9685:SERINC3 ^@ http://purl.uniprot.org/uniprot/M3VUK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9685:LOC101095308 ^@ http://purl.uniprot.org/uniprot/M3WRG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DCTN6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/9685:CCND3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V351 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:KATNA1 ^@ http://purl.uniprot.org/uniprot/M3WEU7 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/9685:F11R ^@ http://purl.uniprot.org/uniprot/Q2WGK2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ (Microbial infection) In case of orthoreovirus infection, serves as receptor for the virus.|||(Microbial infection) Interacts with calicivirus capsid protein.|||(Microbial infection) Interacts with the orthoreovirus sigma-1 capsid protein.|||(Microbial infection) May act as a cellular receptor for calicivirus.|||Belongs to the immunoglobulin superfamily.|||Cell membrane|||Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with ITGAL (via I-domain).|||Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.|||The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.|||tight junction http://togogenome.org/gene/9685:STARD8 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6F4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:NRN1 ^@ http://purl.uniprot.org/uniprot/M3X8K3 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9685:KCNN4 ^@ http://purl.uniprot.org/uniprot/M3VW01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CYRIA ^@ http://purl.uniprot.org/uniprot/A0A5F5XX33 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9685:ARPC5 ^@ http://purl.uniprot.org/uniprot/M3WMY0 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/9685:RAB3A ^@ http://purl.uniprot.org/uniprot/A0A2I2V025 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9685:ZP3 ^@ http://purl.uniprot.org/uniprot/P48832 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Expressed in oocytes.|||N-glycosylated.|||O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.|||Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers. Interacts with ZP1 and ZP2.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/9685:B9D2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U973 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9685:FOXJ3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UU10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ENTPD6 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0Q6|||http://purl.uniprot.org/uniprot/M3XBJ8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9685:TNFSF14 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2B1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9685:IRAK2 ^@ http://purl.uniprot.org/uniprot/M3WEQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.|||Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. http://togogenome.org/gene/9685:GPR37 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTY3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:RPL3L ^@ http://purl.uniprot.org/uniprot/M3WFN6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9685:NIPSNAP3A ^@ http://purl.uniprot.org/uniprot/A0A2I2UV88 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9685:HOXC6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UX54 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CMAS ^@ http://purl.uniprot.org/uniprot/M3WCA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CMP-NeuNAc synthase family.|||Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).|||Homotetramer; the active enzyme is formed by a dimer of dimers. http://togogenome.org/gene/9685:APC ^@ http://purl.uniprot.org/uniprot/A0A2I2UXG0|||http://purl.uniprot.org/uniprot/A0A5F5XTX7 ^@ Similarity ^@ Belongs to the adenomatous polyposis coli (APC) family. http://togogenome.org/gene/9685:TBCCD1 ^@ http://purl.uniprot.org/uniprot/A0A337SSG9|||http://purl.uniprot.org/uniprot/M3WG95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/9685:TGIF1 ^@ http://purl.uniprot.org/uniprot/M3X9E9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:COA5 ^@ http://purl.uniprot.org/uniprot/M3W257 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/9685:BCORL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5H3 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9685:ANAPC5 ^@ http://purl.uniprot.org/uniprot/M3WGZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/9685:KRTAP24-1 ^@ http://purl.uniprot.org/uniprot/A0A337SJ69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9685:OGT ^@ http://purl.uniprot.org/uniprot/A0A2I2UCU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/9685:PPP1R16A ^@ http://purl.uniprot.org/uniprot/M3WKM3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:MCTS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQ50|||http://purl.uniprot.org/uniprot/A0A2I2URS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/9685:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XSB6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9685:DERL2 ^@ http://purl.uniprot.org/uniprot/M3X8Q0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/M3WWZ5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cell junction|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Lipid droplet|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Postsynaptic density membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle|||growth cone http://togogenome.org/gene/9685:SDR9C7 ^@ http://purl.uniprot.org/uniprot/A0A2I2UG01 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:DERL1 ^@ http://purl.uniprot.org/uniprot/M3XA42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9685:MDGA1 ^@ http://purl.uniprot.org/uniprot/M3W6F6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:CYB5A ^@ http://purl.uniprot.org/uniprot/M3X9M9 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/9685:CDS2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XTP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9685:ETFB ^@ http://purl.uniprot.org/uniprot/M3VZA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9685:MMP10 ^@ http://purl.uniprot.org/uniprot/M3WNA6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:SF3B4 ^@ http://purl.uniprot.org/uniprot/M3WCP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/9685:JUP ^@ http://purl.uniprot.org/uniprot/A0A2I2UBN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9685:TGFB3 ^@ http://purl.uniprot.org/uniprot/M3WKA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/9685:CSN3 ^@ http://purl.uniprot.org/uniprot/M3WKE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kappa-casein family.|||Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.|||Secreted http://togogenome.org/gene/9685:CAMK1G ^@ http://purl.uniprot.org/uniprot/A0A5K1UNP7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:CDKN1B ^@ http://purl.uniprot.org/uniprot/O19001 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity.|||Belongs to the CDI family.|||Cytoplasm|||Endosome|||Forms a ternary complex composed of CCNE1, CDK2 and CDKN1B. Interacts directly with CCNE1; the interaction is inhibited by CDK2-dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome complex; the interaction leads to CDKN1B degradation. Interacts with NUP50; the interaction leads to nuclear import and degradation of phosphorylated CDKN1B. Interacts with CCND1 and SNX6 (By similarity). Interacts (Thr-198-phosphorylated form) with 14-3-3 proteins, binds strongly YWHAQ, weakly YWHAE and YWHAH, but not YWHAB nor YWHAZ; the interaction with YWHAQ results in translocation to the cytoplasm. Interacts with AKT1 and LYN; the interactions lead to cytoplasmic mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest. Forms a ternary complex with CCNA2 and CDK2; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements. Interacts (unphosphorylated form) with CDK2. Forms a complex with CDK2 and SPDYA, but does not directly interact with SPDYA. Forms a ternary complex composed of cyclin D, CDK4 and CDKN1B. Interacts (phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction is required for cyclin D and CDK4 complex assembly, induces nuclear translocation and activates the CDK4 kinase activity. Interacts with GRB2. Interacts with PIM1. Identified in a complex with SKP1, SKP2 and CKS1B. Interacts with UHMK1; the interaction leads to cytoplasmic mislocation, phosphorylation of CDKN1B and inhibition of cell cycle arrest. Interacts also with CDK1. Dephosphorylated on Thr-187 by PPM1H, leading to CDKN1B stability (By similarity).|||Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.|||Nucleus|||Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK1 and CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF (By similarity).Dephosphorylated on Thr-187 by PPM1H, leading to CDKN1B stability (By similarity).|||Subject to degradation in the lysosome. Interaction with SNX6 promotes lysosomal degradation (By similarity).|||Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation (By similarity). http://togogenome.org/gene/9685:CYP26B1 ^@ http://purl.uniprot.org/uniprot/M3WYV1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9685:LOC101091348 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2J9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9685:SDR42E1 ^@ http://purl.uniprot.org/uniprot/M3WW99 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9685:NXT1 ^@ http://purl.uniprot.org/uniprot/M3W5Z3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9685:KIF6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UB30|||http://purl.uniprot.org/uniprot/M3W5V4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:SNRPG ^@ http://purl.uniprot.org/uniprot/A0A337S3F1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9685:LOC101084174 ^@ http://purl.uniprot.org/uniprot/A0A2I2URS3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CR2 ^@ http://purl.uniprot.org/uniprot/A0A337SJR3|||http://purl.uniprot.org/uniprot/A0A337SM81|||http://purl.uniprot.org/uniprot/A0A5F5XQ34|||http://purl.uniprot.org/uniprot/M3WDJ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:STAG3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XVY9|||http://purl.uniprot.org/uniprot/M3X0I3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9685:LOC101098084 ^@ http://purl.uniprot.org/uniprot/A0A2I2UX81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:EIF3H ^@ http://purl.uniprot.org/uniprot/M3WLF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9685:EDC4 ^@ http://purl.uniprot.org/uniprot/M3WHR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EDC4 family.|||P-body http://togogenome.org/gene/9685:VPS26A ^@ http://purl.uniprot.org/uniprot/A0A337S4V0|||http://purl.uniprot.org/uniprot/M3XEG2 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/9685:DDA1 ^@ http://purl.uniprot.org/uniprot/M3VVT7 ^@ Similarity ^@ Belongs to the DDA1 family. http://togogenome.org/gene/9685:TXNL4B ^@ http://purl.uniprot.org/uniprot/M3W4S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9685:HYLS1 ^@ http://purl.uniprot.org/uniprot/A0A337SEI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HYLS1 family.|||centriole|||cilium http://togogenome.org/gene/9685:ZNF394 ^@ http://purl.uniprot.org/uniprot/M3XD21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVQ2|||http://purl.uniprot.org/uniprot/A0A337SJI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the osteopontin family.|||Secreted http://togogenome.org/gene/9685:RPL39 ^@ http://purl.uniprot.org/uniprot/A0A2I2UY38 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9685:CCR7 ^@ http://purl.uniprot.org/uniprot/A0A2I2V2J2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:PPP1R9A ^@ http://purl.uniprot.org/uniprot/A0A5F5Y4Z1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:DDR1 ^@ http://purl.uniprot.org/uniprot/A0A337SRG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:EIF4G1 ^@ http://purl.uniprot.org/uniprot/M3W8E0 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9685:LOC101095517 ^@ http://purl.uniprot.org/uniprot/M3WPW3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101083228 ^@ http://purl.uniprot.org/uniprot/M3WNT2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:PNLDC1 ^@ http://purl.uniprot.org/uniprot/M3VZ91 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9685:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/M3W9J5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9685:PHLDA1 ^@ http://purl.uniprot.org/uniprot/M3XA40 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:LOC101088237 ^@ http://purl.uniprot.org/uniprot/A0A337SD17 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:RIC3 ^@ http://purl.uniprot.org/uniprot/A0A337SEY3 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/9685:HTATSF1 ^@ http://purl.uniprot.org/uniprot/M3XB09 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/9685:AP1S1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UW94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9685:SLC35F6 ^@ http://purl.uniprot.org/uniprot/M3XFJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9685:NTAQ1 ^@ http://purl.uniprot.org/uniprot/A0A337S6K4|||http://purl.uniprot.org/uniprot/M3WR90 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/9685:PDIA3 ^@ http://purl.uniprot.org/uniprot/M3W668 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9685:CAMLG ^@ http://purl.uniprot.org/uniprot/M3XG72 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. http://togogenome.org/gene/9685:PSMB5 ^@ http://purl.uniprot.org/uniprot/A0A337SNC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:GP6 ^@ http://purl.uniprot.org/uniprot/M3WSF8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:PPT2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XW18 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/9685:FELCATV1R13 ^@ http://purl.uniprot.org/uniprot/M3XCI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SLC25A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUV9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:ESCO1 ^@ http://purl.uniprot.org/uniprot/M3WGS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ELOVL4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7Q6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.|||Endoplasmic reticulum membrane|||Membrane|||Oligomer.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9685:STK32A ^@ http://purl.uniprot.org/uniprot/M3W983 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:MOCS2 ^@ http://purl.uniprot.org/uniprot/M3WV85 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.|||cytosol http://togogenome.org/gene/9685:CYB5R2 ^@ http://purl.uniprot.org/uniprot/M3W5X3 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9685:TMED9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:PNLIPRP1 ^@ http://purl.uniprot.org/uniprot/M3WPS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9685:SPCS1 ^@ http://purl.uniprot.org/uniprot/M3WUM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:ARMT1 ^@ http://purl.uniprot.org/uniprot/M3WCV6 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/9685:TIMM44 ^@ http://purl.uniprot.org/uniprot/M3WLN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tim44 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:NDUFB9 ^@ http://purl.uniprot.org/uniprot/A0A337SB28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:MRPL27 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTF3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9685:JPT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:NDUFB4 ^@ http://purl.uniprot.org/uniprot/M3X3W9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:PABIR2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XKZ8|||http://purl.uniprot.org/uniprot/A0A5F5XSY8|||http://purl.uniprot.org/uniprot/M3W2G3|||http://purl.uniprot.org/uniprot/M3X693 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9685:ALG5 ^@ http://purl.uniprot.org/uniprot/M3W109 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9685:GYS2 ^@ http://purl.uniprot.org/uniprot/M3WHA7 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9685:GALNT11 ^@ http://purl.uniprot.org/uniprot/M3W9X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:DLX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U019 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9685:LOC101099075 ^@ http://purl.uniprot.org/uniprot/Q1T770 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9685:C2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4P2|||http://purl.uniprot.org/uniprot/A0A5F5XU26 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:CMC4 ^@ http://purl.uniprot.org/uniprot/M3WVW6 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9685:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9Z1|||http://purl.uniprot.org/uniprot/A0A2I2UXB7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9685:COG4 ^@ http://purl.uniprot.org/uniprot/M3WBJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9685:ADAM22 ^@ http://purl.uniprot.org/uniprot/A0A2I2UK80|||http://purl.uniprot.org/uniprot/A0A337SAP5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:PPP2CA ^@ http://purl.uniprot.org/uniprot/A0A2I2V1P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9685:LAMTOR5 ^@ http://purl.uniprot.org/uniprot/M3X6X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/9685:DNMT3B ^@ http://purl.uniprot.org/uniprot/A0A337SSV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/9685:ITPRIP ^@ http://purl.uniprot.org/uniprot/A0A5F5XI11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9685:FIS1 ^@ http://purl.uniprot.org/uniprot/A0A337RU63 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/9685:CYSLTR1 ^@ http://purl.uniprot.org/uniprot/M3X6V9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:POLR3F ^@ http://purl.uniprot.org/uniprot/A0A2I2V008 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9685:MRPS27 ^@ http://purl.uniprot.org/uniprot/M3W429 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9685:NSA2 ^@ http://purl.uniprot.org/uniprot/M3WG45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/9685:ERLIN2 ^@ http://purl.uniprot.org/uniprot/M3WMT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9685:SKA1 ^@ http://purl.uniprot.org/uniprot/M3WU02 ^@ Similarity ^@ Belongs to the SKA1 family. http://togogenome.org/gene/9685:NDRG2 ^@ http://purl.uniprot.org/uniprot/A0A337SPG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm http://togogenome.org/gene/9685:TONSL ^@ http://purl.uniprot.org/uniprot/M3WKL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tonsoku family.|||Chromosome http://togogenome.org/gene/9685:SLC11A1 ^@ http://purl.uniprot.org/uniprot/M3VYE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. http://togogenome.org/gene/9685:ATPAF2 ^@ http://purl.uniprot.org/uniprot/M3X082 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/9685:SDAD1 ^@ http://purl.uniprot.org/uniprot/M3W9G3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/9685:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A2I2V211|||http://purl.uniprot.org/uniprot/A0A5F5XT31|||http://purl.uniprot.org/uniprot/M3VVI9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9685:NPY1R ^@ http://purl.uniprot.org/uniprot/M3W4X9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:SLC45A2 ^@ http://purl.uniprot.org/uniprot/B2ZHD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3I2|||http://purl.uniprot.org/uniprot/A0A2I2V3A0|||http://purl.uniprot.org/uniprot/M3WKN9 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9685:IL2RG ^@ http://purl.uniprot.org/uniprot/M3WLD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:FBL ^@ http://purl.uniprot.org/uniprot/M3VZK8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/9685:ACSL1 ^@ http://purl.uniprot.org/uniprot/M3W3F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:FABP2 ^@ http://purl.uniprot.org/uniprot/M3WQY4 ^@ Function|||Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family.|||FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. http://togogenome.org/gene/9685:LECT2 ^@ http://purl.uniprot.org/uniprot/M3WKX0 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/9685:QKI ^@ http://purl.uniprot.org/uniprot/Q7JJZ8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the quaking family.|||Cytoplasm|||Homodimer; does not require RNA to homodimerize (By similarity). Able to heterodimerize with BICC1 (By similarity).|||Methylated by PRMT1.|||Nucleus|||RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Plays a central role in myelinization via 3 distinct mechanisms (By similarity). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation. Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA. Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation. Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (By similarity). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts. Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1. Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (By similarity). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity).|||The KH domain and the Qua2 region are involved in RNA binding.|||Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).|||Ubiquitinated by RNF6 in macrophages, leading to its degradation. http://togogenome.org/gene/9685:ITPA ^@ http://purl.uniprot.org/uniprot/A0A337S0L8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/9685:CDH7 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHD2|||http://purl.uniprot.org/uniprot/M3WP22 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:FOXP1 ^@ http://purl.uniprot.org/uniprot/M3WVD8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ZP4 ^@ http://purl.uniprot.org/uniprot/P48834 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the ZP domain family. ZPB subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.|||Expressed in oocytes.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/9685:BCO2 ^@ http://purl.uniprot.org/uniprot/M3W5I3 ^@ Cofactor|||Similarity ^@ Belongs to the carotenoid oxygenase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/9685:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A2I2UC36|||http://purl.uniprot.org/uniprot/A0A2I2UDT3|||http://purl.uniprot.org/uniprot/A0A2I2V279|||http://purl.uniprot.org/uniprot/A0A337S301|||http://purl.uniprot.org/uniprot/A0A337SI73|||http://purl.uniprot.org/uniprot/M3WCM2 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9685:CCDC85A ^@ http://purl.uniprot.org/uniprot/A0A2I2U6A6|||http://purl.uniprot.org/uniprot/A0A2I2USC7|||http://purl.uniprot.org/uniprot/A0A2I2UT97|||http://purl.uniprot.org/uniprot/M3VVE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9685:SSR2 ^@ http://purl.uniprot.org/uniprot/A0A337SDR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9685:SULF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7J5|||http://purl.uniprot.org/uniprot/M3WGN2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9685:HTR1B ^@ http://purl.uniprot.org/uniprot/Q588Y6 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.|||Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).|||Homodimer. Heterodimer with HTR1D (By similarity).|||Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.|||Palmitoylated.|||Phosphorylated. http://togogenome.org/gene/9685:LOC101082797 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y484 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:EIF1AX ^@ http://purl.uniprot.org/uniprot/A0A337S322 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. http://togogenome.org/gene/9685:H1-5 ^@ http://purl.uniprot.org/uniprot/M3W584 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9685:LGI4 ^@ http://purl.uniprot.org/uniprot/A0A2Z5XVT7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9685:USP4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQD5|||http://purl.uniprot.org/uniprot/M3WC91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9685:RECQL5 ^@ http://purl.uniprot.org/uniprot/M3W4M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9685:P2RX7 ^@ http://purl.uniprot.org/uniprot/M3WGZ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9685:ZNF174 ^@ http://purl.uniprot.org/uniprot/A0A337RU12|||http://purl.uniprot.org/uniprot/M3WGM4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101098086 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQ06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SMIM24 ^@ http://purl.uniprot.org/uniprot/A0A5F5XSJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ACP1 ^@ http://purl.uniprot.org/uniprot/A0A337S8L4|||http://purl.uniprot.org/uniprot/A0A337STI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9685:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/M3XCB3 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/9685:B3GNT2 ^@ http://purl.uniprot.org/uniprot/M3WAQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:LOC101093295 ^@ http://purl.uniprot.org/uniprot/M3XG15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SLC18B1 ^@ http://purl.uniprot.org/uniprot/M3WEJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PLA2G3 ^@ http://purl.uniprot.org/uniprot/A0A337SPW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9685:TOP3B ^@ http://purl.uniprot.org/uniprot/M3VYV1 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/9685:LOC101081371 ^@ http://purl.uniprot.org/uniprot/A0A7R8C3W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9685:VPS16 ^@ http://purl.uniprot.org/uniprot/M3VXC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS16 family.|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||Vesicle http://togogenome.org/gene/9685:CFL1 ^@ http://purl.uniprot.org/uniprot/M3WIJ6 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9685:CLSPN ^@ http://purl.uniprot.org/uniprot/A0A2I2U4M4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TMBIM1 ^@ http://purl.uniprot.org/uniprot/M3VYE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9685:SCMH1 ^@ http://purl.uniprot.org/uniprot/M3WMD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9685:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/M3WXZ6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9685:KIF22 ^@ http://purl.uniprot.org/uniprot/M3WK55 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:BANF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UDG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:MCOLN1 ^@ http://purl.uniprot.org/uniprot/M3W9B1 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9685:MED22 ^@ http://purl.uniprot.org/uniprot/M3W4S0 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9685:ALDOB ^@ http://purl.uniprot.org/uniprot/M3VWL2 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9685:ZDHHC2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XGN1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:ELOVL2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y4H9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL2 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9685:INS ^@ http://purl.uniprot.org/uniprot/P06306 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/9685:CREM ^@ http://purl.uniprot.org/uniprot/A0A5F5XQ36 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TSPAN8 ^@ http://purl.uniprot.org/uniprot/A0A2I2UB49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:LOC101097942 ^@ http://purl.uniprot.org/uniprot/M3XFW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:OSBP2 ^@ http://purl.uniprot.org/uniprot/M3W1K3 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9685:CCHCR1 ^@ http://purl.uniprot.org/uniprot/M3WNJ0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a regulator of keratinocyte proliferation or differentiation.|||Nucleus http://togogenome.org/gene/9685:LOC109498222 ^@ http://purl.uniprot.org/uniprot/A0A2I2U557 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:EDNRB ^@ http://purl.uniprot.org/uniprot/A0A337SDI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:ST6GALNAC3 ^@ http://purl.uniprot.org/uniprot/M3WK21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:GPR132 ^@ http://purl.uniprot.org/uniprot/A0A337SI48 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A337RYT0|||http://purl.uniprot.org/uniprot/M3W053 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9685:ZNF326 ^@ http://purl.uniprot.org/uniprot/M3X8Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AKAP95 family.|||Nucleus matrix http://togogenome.org/gene/9685:MCM3 ^@ http://purl.uniprot.org/uniprot/M3X046 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9685:DCAF11 ^@ http://purl.uniprot.org/uniprot/M3W4B4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat LEC14B family.|||Interacts with DDB1 and CUL4A.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/9685:ACOX1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y851|||http://purl.uniprot.org/uniprot/M3W4N4|||http://purl.uniprot.org/uniprot/M3WR09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9685:NDUFAB1 ^@ http://purl.uniprot.org/uniprot/M3WIH4 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/9685:LOC677877 ^@ http://purl.uniprot.org/uniprot/P30438 ^@ Allergen|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the secretoglobin family.|||Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.|||Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.|||Saliva and sebaceous glands.|||Secreted http://togogenome.org/gene/9685:HPF1 ^@ http://purl.uniprot.org/uniprot/M3X8Z5 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/9685:ABRAXAS1 ^@ http://purl.uniprot.org/uniprot/M3WPD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abraxas subfamily.|||Nucleus http://togogenome.org/gene/9685:ORC4 ^@ http://purl.uniprot.org/uniprot/A0A337SL77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9685:SSTR4 ^@ http://purl.uniprot.org/uniprot/M3X0A6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:BMP5 ^@ http://purl.uniprot.org/uniprot/M3W2A2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9685:ERG ^@ http://purl.uniprot.org/uniprot/A0A2I2UEM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:NPSR1 ^@ http://purl.uniprot.org/uniprot/M3W6Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:CHRNA7 ^@ http://purl.uniprot.org/uniprot/A0A337SQQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:LOC101090130 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y5V2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TNFSF4 ^@ http://purl.uniprot.org/uniprot/A0S0B2 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9685:MAP2K6 ^@ http://purl.uniprot.org/uniprot/M3WN25 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:INTS13 ^@ http://purl.uniprot.org/uniprot/M3W203 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:HAUS3 ^@ http://purl.uniprot.org/uniprot/M3WWN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/9685:GCNT3 ^@ http://purl.uniprot.org/uniprot/M3WHV2 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:EDNRA ^@ http://purl.uniprot.org/uniprot/M3WMJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9685:LOC101081492 ^@ http://purl.uniprot.org/uniprot/M3WNA2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:LOC101080445 ^@ http://purl.uniprot.org/uniprot/M3WYZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:FXYD2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2J8|||http://purl.uniprot.org/uniprot/A0A5F5Y0E2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FXYD family.|||May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.|||Membrane|||Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. http://togogenome.org/gene/9685:NEDD8 ^@ http://purl.uniprot.org/uniprot/M3W4C3 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/9685:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9685:FOXS1 ^@ http://purl.uniprot.org/uniprot/M3VXH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CSMD3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UG55|||http://purl.uniprot.org/uniprot/A0A337SPJ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SIN3A ^@ http://purl.uniprot.org/uniprot/M3WEZ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:UQCRQ ^@ http://purl.uniprot.org/uniprot/M3X026 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:APPL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UME8 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9685:CHRNA6 ^@ http://purl.uniprot.org/uniprot/M3X1Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:MAP7D2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5N3|||http://purl.uniprot.org/uniprot/A0A337SBP6|||http://purl.uniprot.org/uniprot/A0A337SNL7|||http://purl.uniprot.org/uniprot/M3WDY0 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9685:P2RX3 ^@ http://purl.uniprot.org/uniprot/A0A337S2N6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9685:MARCHF4 ^@ http://purl.uniprot.org/uniprot/M3W0E6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:NDFIP2 ^@ http://purl.uniprot.org/uniprot/M3WXI8 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9685:DDI2 ^@ http://purl.uniprot.org/uniprot/A0A337SIM1|||http://purl.uniprot.org/uniprot/A0A5F5XPF9|||http://purl.uniprot.org/uniprot/M3WFC7 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/9685:NTRK3 ^@ http://purl.uniprot.org/uniprot/A0A337RW69|||http://purl.uniprot.org/uniprot/A0A337S8F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:ETFDH ^@ http://purl.uniprot.org/uniprot/U5Q9M7 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9685:ATP5MG ^@ http://purl.uniprot.org/uniprot/A0A337SSK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/9685:ICOS ^@ http://purl.uniprot.org/uniprot/A0A2I2ULM3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9685:ACE2 ^@ http://purl.uniprot.org/uniprot/A0A7D5GAH0|||http://purl.uniprot.org/uniprot/Q56H28 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the peptidase M2 family.|||Binds 1 Cl(-) ion per subunit.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity.|||Homodimer. Interacts with the catalytically active form of TMPRSS2 (By similarity). Interacts with SLC6A19; this interaction is essential for expression and function of SLC6A19 in intestine (By similarity). Interacts with ITGA5:ITGB1 (By similarity). Probably interacts (via endocytic sorting signal motif) with AP2M1; the interaction is inhibited by phosphorylation of Tyr-781 (By similarity). Interacts (via PDZ-binding motif) with NHERF1 (via PDZ domains); the interaction may enhance ACE2 membrane residence (By similarity).|||Membrane|||Phosphorylated. Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains.|||Proteolytic cleavage by ADAM17 generates a secreted form. Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1 (By similarity).|||Secreted|||The cytoplasmic tail contains several linear motifs such as LIR, PDZ-binding, PTB and endocytic sorting signal motifs that would allow interaction with proteins that mediate endocytic trafficking and autophagy.|||cilium http://togogenome.org/gene/9685:TPT1 ^@ http://purl.uniprot.org/uniprot/M3VXX1 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9685:IMMP1L ^@ http://purl.uniprot.org/uniprot/M3X386 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:FRRS1 ^@ http://purl.uniprot.org/uniprot/M3XEV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRRS1 family.|||Membrane http://togogenome.org/gene/9685:GSTCD ^@ http://purl.uniprot.org/uniprot/M3WWR6 ^@ Similarity ^@ Belongs to the GSTCD family. http://togogenome.org/gene/9685:ACTR1B ^@ http://purl.uniprot.org/uniprot/M3XDN6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:UBE2R2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UT95 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9685:FAM216B ^@ http://purl.uniprot.org/uniprot/A0A2I2UBY9 ^@ Similarity ^@ Belongs to the FAM216 family. http://togogenome.org/gene/9685:PHYHIPL ^@ http://purl.uniprot.org/uniprot/M3WRV0 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9685:TRAPPC6A ^@ http://purl.uniprot.org/uniprot/M3WRW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9685:LRRC7 ^@ http://purl.uniprot.org/uniprot/A0A5F5XDW9 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9685:GPX6 ^@ http://purl.uniprot.org/uniprot/A0A5F5XKJ5|||http://purl.uniprot.org/uniprot/M3W083 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9685:BUD23 ^@ http://purl.uniprot.org/uniprot/M3W2S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:BCR ^@ http://purl.uniprot.org/uniprot/M3WRN9 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/9685:TRAF3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTY9|||http://purl.uniprot.org/uniprot/M3WCI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9685:FELCATV1R2 ^@ http://purl.uniprot.org/uniprot/M3XG92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:TFIP11 ^@ http://purl.uniprot.org/uniprot/M3WUA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/9685:PTGDR ^@ http://purl.uniprot.org/uniprot/A0A337SA56 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:KCNJ8 ^@ http://purl.uniprot.org/uniprot/M3WS09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9685:GIMAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8K3 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9685:TXLNA ^@ http://purl.uniprot.org/uniprot/M3WW86 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9685:ASPDH ^@ http://purl.uniprot.org/uniprot/M3WLS9 ^@ Similarity ^@ Belongs to the L-aspartate dehydrogenase family. http://togogenome.org/gene/9685:ABCB7 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y5L5|||http://purl.uniprot.org/uniprot/M3WBN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:IL1R1 ^@ http://purl.uniprot.org/uniprot/M3WGF1 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9685:SCARB2 ^@ http://purl.uniprot.org/uniprot/M3VW08 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9685:FZD1 ^@ http://purl.uniprot.org/uniprot/M3X4M3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:LOC101091384 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFU6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9685:NKAP ^@ http://purl.uniprot.org/uniprot/M3W237 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9685:ISG15 ^@ http://purl.uniprot.org/uniprot/B3IX46 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9685:CF1H1orf43 ^@ http://purl.uniprot.org/uniprot/M3WH87 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/9685:RAB27A ^@ http://purl.uniprot.org/uniprot/A0A2I2UDJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9685:DHH ^@ http://purl.uniprot.org/uniprot/A0A2I2V005 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/9685:ALG6 ^@ http://purl.uniprot.org/uniprot/M3X9T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:RPL7A ^@ http://purl.uniprot.org/uniprot/A0A2I2U4W2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/9685:CACNA2D4 ^@ http://purl.uniprot.org/uniprot/M3X5Z3 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9685:DNAAF1 ^@ http://purl.uniprot.org/uniprot/M3WFB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNAAF1 family.|||Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.|||cilium http://togogenome.org/gene/9685:CYBC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:OXA1L ^@ http://purl.uniprot.org/uniprot/M3W679 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/9685:LHX4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPI3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CTH ^@ http://purl.uniprot.org/uniprot/M3WGZ1 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/9685:DGAT1 ^@ http://purl.uniprot.org/uniprot/M3W886 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/9685:SLC25A21 ^@ http://purl.uniprot.org/uniprot/A0A337S7D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:GATC ^@ http://purl.uniprot.org/uniprot/A0A2I2U0Z9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9685:GABRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:AIG1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y0V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9685:PTGR2 ^@ http://purl.uniprot.org/uniprot/M3WRI9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9685:ACRBP ^@ http://purl.uniprot.org/uniprot/M3W6N5 ^@ Subcellular Location Annotation ^@ acrosome http://togogenome.org/gene/9685:MRPS25 ^@ http://purl.uniprot.org/uniprot/M3X9W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9685:FAM13A ^@ http://purl.uniprot.org/uniprot/A0A2I2UM86|||http://purl.uniprot.org/uniprot/A0A2I2UV00|||http://purl.uniprot.org/uniprot/M3WMQ8 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9685:FGFR2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y2A8|||http://purl.uniprot.org/uniprot/A0A5F5Y433 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:CHPT1 ^@ http://purl.uniprot.org/uniprot/M3XC97 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9685:CHMP2B ^@ http://purl.uniprot.org/uniprot/M3WYZ6 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9685:KIF5B ^@ http://purl.uniprot.org/uniprot/M3WU61 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:LOC101094786 ^@ http://purl.uniprot.org/uniprot/A0A5F5XQ16 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SLC20A1 ^@ http://purl.uniprot.org/uniprot/O97596 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Cell membrane|||Ectopic expression of feline SLC20A1 in guinea pig cells which are not permissive to Feline leukemia virus subgroup B (FeLV-B) confers susceptibility to FeLV-B infection.|||Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Essential for cell proliferation but this function is independent of its phosphate transporter activity. http://togogenome.org/gene/9685:EPC2 ^@ http://purl.uniprot.org/uniprot/A0A337SGT8|||http://purl.uniprot.org/uniprot/M3X061 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9685:EME1 ^@ http://purl.uniprot.org/uniprot/M3WGQ9 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/9685:LOC101098213 ^@ http://purl.uniprot.org/uniprot/M3X7H4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9685:AMZ2 ^@ http://purl.uniprot.org/uniprot/M3WP90 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9685:HENMT1 ^@ http://purl.uniprot.org/uniprot/M3W191 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/9685:TRAM2 ^@ http://purl.uniprot.org/uniprot/M3VZI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9685:SI ^@ http://purl.uniprot.org/uniprot/B1Q4L3 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:NUBPL ^@ http://purl.uniprot.org/uniprot/M3WTW9 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/9685:IFNA8 ^@ http://purl.uniprot.org/uniprot/Q863J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9685:ZC3H12B ^@ http://purl.uniprot.org/uniprot/A0A2I2UF15 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9685:PDCL ^@ http://purl.uniprot.org/uniprot/M3X7C8 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9685:LOC101100439 ^@ http://purl.uniprot.org/uniprot/M3XBF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PTK6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9685:RETREG3 ^@ http://purl.uniprot.org/uniprot/M3WFI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:LOC101085463 ^@ http://purl.uniprot.org/uniprot/M3X6T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:ERCC3 ^@ http://purl.uniprot.org/uniprot/M3W6V7 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/9685:MLF1 ^@ http://purl.uniprot.org/uniprot/A0A337SDK2|||http://purl.uniprot.org/uniprot/M3WR71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9685:ARHGAP32 ^@ http://purl.uniprot.org/uniprot/A0A5F5XT37|||http://purl.uniprot.org/uniprot/M3WI54 ^@ Similarity ^@ Belongs to the PX domain-containing GAP family. http://togogenome.org/gene/9685:ALB ^@ http://purl.uniprot.org/uniprot/P49064 ^@ Allergen|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the ALB/AFP/VDB family.|||Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).|||Can cause allergic reactions in humans.|||Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.|||Phosphorylated by FAM20C in the extracellular medium.|||Plasma.|||Secreted http://togogenome.org/gene/9685:SLC25A41 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:ZDHHC12 ^@ http://purl.uniprot.org/uniprot/M3W4U2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:RNASE10 ^@ http://purl.uniprot.org/uniprot/M3W6S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9685:TTR ^@ http://purl.uniprot.org/uniprot/M3WEV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9685:S100A4 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHL3|||http://purl.uniprot.org/uniprot/M3WK06 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9685:ACADL ^@ http://purl.uniprot.org/uniprot/M3WYQ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9685:SUOX ^@ http://purl.uniprot.org/uniprot/M3WZ66 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.|||Mitochondrion intermembrane space http://togogenome.org/gene/9685:PI4KB ^@ http://purl.uniprot.org/uniprot/M3W4A4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9685:GRK1 ^@ http://purl.uniprot.org/uniprot/M3W6P7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9685:VPS33B ^@ http://purl.uniprot.org/uniprot/A0A337SIS2|||http://purl.uniprot.org/uniprot/M3WG33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9685:MRPL58 ^@ http://purl.uniprot.org/uniprot/A0A2I2U715 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9685:OTUD7B ^@ http://purl.uniprot.org/uniprot/M3WCQ0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:SGO2 ^@ http://purl.uniprot.org/uniprot/M3XC61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/9685:GTF2H4 ^@ http://purl.uniprot.org/uniprot/M3WNZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/9685:SMIM5 ^@ http://purl.uniprot.org/uniprot/M3X8J7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PPP2CB ^@ http://purl.uniprot.org/uniprot/M3X2E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9685:EFS ^@ http://purl.uniprot.org/uniprot/M3X1T8 ^@ Similarity ^@ Belongs to the CAS family. http://togogenome.org/gene/9685:SLC30A3 ^@ http://purl.uniprot.org/uniprot/M3WSD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9685:CD40LG ^@ http://purl.uniprot.org/uniprot/O97605 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell membrane|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).|||Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).|||Secreted|||The soluble form derives from the membrane form by proteolytic processing. http://togogenome.org/gene/9685:DCTN2 ^@ http://purl.uniprot.org/uniprot/A0A337SGM4|||http://purl.uniprot.org/uniprot/A0A337STK3|||http://purl.uniprot.org/uniprot/M3VXV6 ^@ Similarity ^@ Belongs to the dynactin subunit 2 family. http://togogenome.org/gene/9685:NOSTRIN ^@ http://purl.uniprot.org/uniprot/A0A2I2UBP1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:MFNG ^@ http://purl.uniprot.org/uniprot/M3W6C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:DNAJC18 ^@ http://purl.uniprot.org/uniprot/M3VX61 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:ARMCX1 ^@ http://purl.uniprot.org/uniprot/M3XB21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9685:PPOX ^@ http://purl.uniprot.org/uniprot/M3WN79 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:KIAA1191 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0G0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P33MONOX family.|||Cytoplasm|||Interacts with NELFB, NOL12 and PRNP.|||Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. http://togogenome.org/gene/9685:BDH1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6J3|||http://purl.uniprot.org/uniprot/M3WPA3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:CA2H19orf25 ^@ http://purl.uniprot.org/uniprot/M3VX98 ^@ Similarity ^@ Belongs to the UPF0449 family. http://togogenome.org/gene/9685:ZSCAN22 ^@ http://purl.uniprot.org/uniprot/M3WU60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:HAAO ^@ http://purl.uniprot.org/uniprot/M3VUF1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/9685:PRDX6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UL25 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9685:REEP5 ^@ http://purl.uniprot.org/uniprot/M3WUT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9685:CA2H7orf25 ^@ http://purl.uniprot.org/uniprot/M3WJB3 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/9685:ANXA1 ^@ http://purl.uniprot.org/uniprot/Q6BCI9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Early endosome|||Endosome|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9685:SOX2 ^@ http://purl.uniprot.org/uniprot/D3U659 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SRP68 ^@ http://purl.uniprot.org/uniprot/M3W4N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9685:TDGF1 ^@ http://purl.uniprot.org/uniprot/M3WKU3 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CALB1 ^@ http://purl.uniprot.org/uniprot/A0A337RZZ8 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. http://togogenome.org/gene/9685:FSHB ^@ http://purl.uniprot.org/uniprot/M3WL17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9685:NFE2 ^@ http://purl.uniprot.org/uniprot/M3XA95 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9685:SIVA1 ^@ http://purl.uniprot.org/uniprot/M3W364 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus|||Phosphorylated by ABL2/ARG in response to oxidative stress. http://togogenome.org/gene/9685:PIGN ^@ http://purl.uniprot.org/uniprot/A0A2I2U8X7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/9685:TMEM59 ^@ http://purl.uniprot.org/uniprot/M3X067 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:CCT6B ^@ http://purl.uniprot.org/uniprot/A0A337S679 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9685:BLMH ^@ http://purl.uniprot.org/uniprot/M3W1G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/9685:KCNS3 ^@ http://purl.uniprot.org/uniprot/M3WKD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:USP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2URI0|||http://purl.uniprot.org/uniprot/A0A337S1E0 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9685:ESD ^@ http://purl.uniprot.org/uniprot/M3XAF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9685:GHRH ^@ http://purl.uniprot.org/uniprot/M3W6V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/9685:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/M3WAV4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9685:ZNF500 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:KCNF1 ^@ http://purl.uniprot.org/uniprot/M3XEL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:COG3 ^@ http://purl.uniprot.org/uniprot/M3W302 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Involved in ER-Golgi transport. http://togogenome.org/gene/9685:FOXP3 ^@ http://purl.uniprot.org/uniprot/A0A337S119|||http://purl.uniprot.org/uniprot/A3RJW9|||http://purl.uniprot.org/uniprot/M3W117 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SEPTIN6 ^@ http://purl.uniprot.org/uniprot/A0A2I2U142|||http://purl.uniprot.org/uniprot/A0A2I2UPK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9685:EYA4 ^@ http://purl.uniprot.org/uniprot/A0A337SUI7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9685:MTTP ^@ http://purl.uniprot.org/uniprot/A0A337SN26 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:MRPL54 ^@ http://purl.uniprot.org/uniprot/M3W769 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/9685:CD37 ^@ http://purl.uniprot.org/uniprot/M3VWB3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:AGPAT5 ^@ http://purl.uniprot.org/uniprot/M3WJL1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9685:PPP4R3A ^@ http://purl.uniprot.org/uniprot/M3WT68 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9685:LOC101096269 ^@ http://purl.uniprot.org/uniprot/A0A2I2U996 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:USP26 ^@ http://purl.uniprot.org/uniprot/M3WQL5 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9685:GCG ^@ http://purl.uniprot.org/uniprot/M3XDH4 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9685:USB1 ^@ http://purl.uniprot.org/uniprot/M3VYZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/9685:CENPX ^@ http://purl.uniprot.org/uniprot/A0A337SG66 ^@ Similarity ^@ Belongs to the CENP-X/MHF2 family. http://togogenome.org/gene/9685:LOC101084019 ^@ http://purl.uniprot.org/uniprot/A0A337SHJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DUSP6 ^@ http://purl.uniprot.org/uniprot/M3XBD2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9685:NUDT4 ^@ http://purl.uniprot.org/uniprot/M3X267 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9685:RBM17 ^@ http://purl.uniprot.org/uniprot/M3XE89 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/9685:PHB2 ^@ http://purl.uniprot.org/uniprot/M3X4F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:YEATS2 ^@ http://purl.uniprot.org/uniprot/M3VZR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101099779 ^@ http://purl.uniprot.org/uniprot/A0A337SI27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9685:HNRNPK ^@ http://purl.uniprot.org/uniprot/M3WLH7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9685:PHF20 ^@ http://purl.uniprot.org/uniprot/M3X8M9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CELA1 ^@ http://purl.uniprot.org/uniprot/Q5R1M5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Elastase subfamily.|||Binds 1 Ca(2+) ion per subunit.|||Secreted|||Serine proteases that hydrolyze many proteins in addition to elastin. http://togogenome.org/gene/9685:COQ10B ^@ http://purl.uniprot.org/uniprot/M3X968 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9685:PGD ^@ http://purl.uniprot.org/uniprot/M3WKZ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/9685:SLC25A14 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPM0|||http://purl.uniprot.org/uniprot/M3W9M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:XPOT ^@ http://purl.uniprot.org/uniprot/A0A337SM31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9685:LOC101093045 ^@ http://purl.uniprot.org/uniprot/A0A2I2USS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:BMPR1B ^@ http://purl.uniprot.org/uniprot/A0A2I2UWR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9685:IPO13 ^@ http://purl.uniprot.org/uniprot/M3W600 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/9685:GAD1 ^@ http://purl.uniprot.org/uniprot/P14748 ^@ Function|||Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.|||Homodimer. http://togogenome.org/gene/9685:FGA ^@ http://purl.uniprot.org/uniprot/M3W022 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9685:GPX8 ^@ http://purl.uniprot.org/uniprot/M3X4H0 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9685:NTS ^@ http://purl.uniprot.org/uniprot/M3X5C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9685:ITIH2 ^@ http://purl.uniprot.org/uniprot/A0A337SQW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9685:DPH5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UH15 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9685:COX7B2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:HBS1L ^@ http://purl.uniprot.org/uniprot/A0A2I2U966 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:GPN2 ^@ http://purl.uniprot.org/uniprot/M3WHP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9685:NSUN7 ^@ http://purl.uniprot.org/uniprot/A0A337SAG4 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:WDR46 ^@ http://purl.uniprot.org/uniprot/M3W1E4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9685:ESS2 ^@ http://purl.uniprot.org/uniprot/M3WQ59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/9685:RPS25 ^@ http://purl.uniprot.org/uniprot/M3VW27 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9685:CDK2AP2 ^@ http://purl.uniprot.org/uniprot/A0A337SBV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9685:SLC5A12 ^@ http://purl.uniprot.org/uniprot/M3WJJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SERPINI2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTJ5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:SUPT16H ^@ http://purl.uniprot.org/uniprot/M3WJL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/9685:CES1 ^@ http://purl.uniprot.org/uniprot/Q766D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9685:NFYA ^@ http://purl.uniprot.org/uniprot/A0A2I2U126|||http://purl.uniprot.org/uniprot/M3WUH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9685:CALCRL ^@ http://purl.uniprot.org/uniprot/A0A337SIF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.|||Membrane|||Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9685:TMEM267 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:MYOF ^@ http://purl.uniprot.org/uniprot/A0A2I2UE28|||http://purl.uniprot.org/uniprot/A0A2I2UXC0|||http://purl.uniprot.org/uniprot/A0A2I2UYS8|||http://purl.uniprot.org/uniprot/M3WCE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferlin family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9685:GCDH ^@ http://purl.uniprot.org/uniprot/M3VUU6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9685:FAM210A ^@ http://purl.uniprot.org/uniprot/M3X2D5 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/9685:GRB7 ^@ http://purl.uniprot.org/uniprot/M3WCC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9685:PPM1B ^@ http://purl.uniprot.org/uniprot/A0A2I2UN37|||http://purl.uniprot.org/uniprot/M3WYG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9685:CLCN4 ^@ http://purl.uniprot.org/uniprot/M3X4P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9685:RNF34 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3K0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:CYYR1 ^@ http://purl.uniprot.org/uniprot/M3WEI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYYR1 family.|||Membrane http://togogenome.org/gene/9685:MLPH ^@ http://purl.uniprot.org/uniprot/M3WHG5 ^@ Function|||Polymorphism|||Subcellular Location Annotation|||Subunit ^@ An allelic variation in MLPH, resulting in a severely truncated protein, has been shown to be associated with the dilute coat color phenotype. This trait is autosomal recessive.|||Binds RAB27A that has been activated by GTP-binding via its N-terminus. Binds MYO5A via its C-terminal coiled coil domain.|||Melanosome|||Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. http://togogenome.org/gene/9685:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:METTL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJG8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with WDR4.|||Nucleus|||Phosphorylation at Ser-28 inactivates its catalytic activity but does not affect the interaction with WDR4. http://togogenome.org/gene/9685:LIF ^@ http://purl.uniprot.org/uniprot/A0A2I2UME6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.|||Secreted http://togogenome.org/gene/9685:MPV17L2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U077 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9685:LOC101083648 ^@ http://purl.uniprot.org/uniprot/M3WFR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:TMEM41A ^@ http://purl.uniprot.org/uniprot/M3W3Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9685:ATP9A ^@ http://purl.uniprot.org/uniprot/A0A2I2UVW2|||http://purl.uniprot.org/uniprot/A0A337S144 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9685:LOC101092631 ^@ http://purl.uniprot.org/uniprot/M3W1B7 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:RELT ^@ http://purl.uniprot.org/uniprot/M3VZA9 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9685:FHL5 ^@ http://purl.uniprot.org/uniprot/M3WQD7 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9685:SUB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UN36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2.|||Nucleus http://togogenome.org/gene/9685:ODF1 ^@ http://purl.uniprot.org/uniprot/M3W6P2 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9685:PNRC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V057 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ESR1 ^@ http://purl.uniprot.org/uniprot/Q53AD2 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with coactivator NCOA5. Interacts with PELP1, the interaction is enhanced by 17-beta-estradiol; the interaction increases ESR1 transcriptional activity (By similarity). Interacts with NCOA7; the interaction is ligand-inducible. Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, MAP1S, SMARD1, and UBE1C. Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ESR1-mediated transcription. Interacts with DNTTIP2, and UIMC1. Interacts with KMT2D/MLL2. Interacts with ATAD2; the interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via its C-terminus). Interacts with MACROD1. Interacts with SH2D4A and PLCG. Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with DNAAF4. Interacts with PRMT2. Interacts with RBFOX2. Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent. Interacts with FAM120B, FOXL2, PHB2 and SLC30A9. Interacts with coactivators NCOA3 and NCOA6. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D. Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy. Interacts with DDX5. Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions. Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3. Interacts with NRIP1. Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts with CLOCK and the interaction is stimulated by estrogen. Interacts with TRIP4 (ufmylated); estrogen dependent. Interacts with LMTK3; the interaction phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with ZFHX3. Interacts with SFR1 in a ligand-dependent and -independent manner. Interacts with DCAF13, LATS1 and DCAF1; regulates ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation. Interacts (via DNA-binding domain) with POU4F2 (C-terminus); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner. Interacts with ESRRB isoform 1. Interacts with UBE3A and WBP2. Interacts with GTF2B. Interacts with RBM39. In the absence of hormonal ligand, interacts with TACC1 (By similarity). Interacts with PI3KR1 or PI3KR2 and PTK2/FAK1 (By similarity). Interacts with SRC (By similarity).|||Cell membrane|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).|||Cytoplasm|||Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-260.|||Golgi apparatus|||Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades.Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).|||Nucleus|||Palmitoylated at Cys-447 by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor (By similarity).|||Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity (By similarity). Phosphorylated by LMTK3 (in vitro) (By similarity).|||Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1. http://togogenome.org/gene/9685:CD3H12orf43 ^@ http://purl.uniprot.org/uniprot/M3WBT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUSTOS family.|||Nucleus envelope http://togogenome.org/gene/9685:EID1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XFX2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:FGF18 ^@ http://purl.uniprot.org/uniprot/M3W721 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9685:TMC7 ^@ http://purl.uniprot.org/uniprot/M3X9J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9685:TRIM45 ^@ http://purl.uniprot.org/uniprot/M3W3N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9685:TBCB ^@ http://purl.uniprot.org/uniprot/M3X835 ^@ Similarity ^@ Belongs to the TBCB family. http://togogenome.org/gene/9685:NR6A1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XWG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9685:ATG16L2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZF4|||http://purl.uniprot.org/uniprot/M3WIE2 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9685:KITLG ^@ http://purl.uniprot.org/uniprot/P79169 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.|||Belongs to the SCF family.|||Cell membrane|||Cytoplasm|||Homodimer, non-covalently linked.|||Secreted|||Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity).|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9685:FAM219B ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ08 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9685:GNA14 ^@ http://purl.uniprot.org/uniprot/M3W9N2 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9685:SUSD2 ^@ http://purl.uniprot.org/uniprot/M3WBD8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LOC101083947 ^@ http://purl.uniprot.org/uniprot/M3X952 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TGM2 ^@ http://purl.uniprot.org/uniprot/M3W2W5 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9685:MCEE ^@ http://purl.uniprot.org/uniprot/A0A2I2UYE6 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9685:SMC1A ^@ http://purl.uniprot.org/uniprot/M3WJP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9685:PACSIN1 ^@ http://purl.uniprot.org/uniprot/M3WMG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/9685:DENND10 ^@ http://purl.uniprot.org/uniprot/M3WDN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND10 family.|||Endosome|||Late endosome http://togogenome.org/gene/9685:OAS1 ^@ http://purl.uniprot.org/uniprot/M3VUI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9685:LOC101092166 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MED31 ^@ http://purl.uniprot.org/uniprot/M3XD94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9685:ANXA3 ^@ http://purl.uniprot.org/uniprot/M3WET7 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9685:HNRNPC ^@ http://purl.uniprot.org/uniprot/A0A337SDT4 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9685:APLP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UM58|||http://purl.uniprot.org/uniprot/A0A337S8K3|||http://purl.uniprot.org/uniprot/M3WBJ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:RPS15 ^@ http://purl.uniprot.org/uniprot/A0A2I2UE94 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS19 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9685:SNX4 ^@ http://purl.uniprot.org/uniprot/M3X902 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9685:CPM ^@ http://purl.uniprot.org/uniprot/M3WKG9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9685:PIANP ^@ http://purl.uniprot.org/uniprot/M3WYB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RPL36 ^@ http://purl.uniprot.org/uniprot/M3WFV3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9685:TMEM233 ^@ http://purl.uniprot.org/uniprot/A0A2I2V522 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9685:CDCA5 ^@ http://purl.uniprot.org/uniprot/M3XBH5 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9685:LOC101101309 ^@ http://purl.uniprot.org/uniprot/A0A337SN81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TET3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYM9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/9685:TMEM208 ^@ http://purl.uniprot.org/uniprot/M3WQB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9685:WAPL ^@ http://purl.uniprot.org/uniprot/A0A2I2UY07 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/9685:LOC101085477 ^@ http://purl.uniprot.org/uniprot/M3VW66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:FFAR2 ^@ http://purl.uniprot.org/uniprot/A0A7G1GES3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101091946 ^@ http://purl.uniprot.org/uniprot/M3WYR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:THEMIS ^@ http://purl.uniprot.org/uniprot/M3WD74 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9685:KDELR2 ^@ http://purl.uniprot.org/uniprot/M3XA02 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:PLK4 ^@ http://purl.uniprot.org/uniprot/A0A337SPE5 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||centriole http://togogenome.org/gene/9685:ATP2A3 ^@ http://purl.uniprot.org/uniprot/A0A337SUB3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9685:IDH1 ^@ http://purl.uniprot.org/uniprot/M3W1B8 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/9685:MFSD14A ^@ http://purl.uniprot.org/uniprot/M3X3C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9685:PSME1 ^@ http://purl.uniprot.org/uniprot/M3W4B6 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/9685:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTB1|||http://purl.uniprot.org/uniprot/A0A2I2V2C0|||http://purl.uniprot.org/uniprot/A0A337S1I1|||http://purl.uniprot.org/uniprot/A0A337SGE8 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9685:BCL2A1 ^@ http://purl.uniprot.org/uniprot/M3WHW2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9685:ABITRAM ^@ http://purl.uniprot.org/uniprot/A0A2I2UZ38|||http://purl.uniprot.org/uniprot/A0A5F5XKS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/9685:FAM120C ^@ http://purl.uniprot.org/uniprot/M3WR67 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/9685:CASC3 ^@ http://purl.uniprot.org/uniprot/M3WLR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASC3 family.|||Nucleus speckle|||dendrite|||perinuclear region http://togogenome.org/gene/9685:RPSA ^@ http://purl.uniprot.org/uniprot/M3VZ17 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9685:VPS28 ^@ http://purl.uniprot.org/uniprot/M3WKL6 ^@ Function|||Similarity ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. http://togogenome.org/gene/9685:TMEM106A ^@ http://purl.uniprot.org/uniprot/M3WIB2 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9685:TSN ^@ http://purl.uniprot.org/uniprot/M3X4R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/9685:GRPR ^@ http://purl.uniprot.org/uniprot/A0A2I2UJT8|||http://purl.uniprot.org/uniprot/M3VX65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PSMA8 ^@ http://purl.uniprot.org/uniprot/M3XET1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9685:SKIV2L ^@ http://purl.uniprot.org/uniprot/M3W2C0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:EHD3 ^@ http://purl.uniprot.org/uniprot/M3X2J9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9685:MTCH2 ^@ http://purl.uniprot.org/uniprot/M3X0I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A337RYT7|||http://purl.uniprot.org/uniprot/M3X2C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9685:LOC101095289 ^@ http://purl.uniprot.org/uniprot/M3WHJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MUSK ^@ http://purl.uniprot.org/uniprot/M3W234 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:TARDBP ^@ http://purl.uniprot.org/uniprot/A0A2I2U8C8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101086734 ^@ http://purl.uniprot.org/uniprot/M3WTH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GJA4 ^@ http://purl.uniprot.org/uniprot/M3WK01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:TMEM167A ^@ http://purl.uniprot.org/uniprot/A0A337RXP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/9685:FABP6 ^@ http://purl.uniprot.org/uniprot/A0A2I2UB52 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9685:TMEM242 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/9685:DNAJC24 ^@ http://purl.uniprot.org/uniprot/M3X0L0 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/9685:PDRG1 ^@ http://purl.uniprot.org/uniprot/M3X889 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/9685:HMGN4 ^@ http://purl.uniprot.org/uniprot/M3WMG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9685:ALDH9A1 ^@ http://purl.uniprot.org/uniprot/M3W1Z4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9685:TMEM11 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Plays a role in mitochondrial morphogenesis. http://togogenome.org/gene/9685:LOC101086984 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y553 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:ISL1 ^@ http://purl.uniprot.org/uniprot/M3WF59 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ANXA9 ^@ http://purl.uniprot.org/uniprot/M3WBV0 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9685:LIPH ^@ http://purl.uniprot.org/uniprot/A0A337S3D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9685:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQI8|||http://purl.uniprot.org/uniprot/A0A2I2UYG8|||http://purl.uniprot.org/uniprot/A0A2I2V0Y1|||http://purl.uniprot.org/uniprot/M3WZP2 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9685:ENPP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3L7|||http://purl.uniprot.org/uniprot/A0A5F5XFW6|||http://purl.uniprot.org/uniprot/M3WE79|||http://purl.uniprot.org/uniprot/M3XD38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/9685:LOC101085428 ^@ http://purl.uniprot.org/uniprot/A0A2I2UP08 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:OGFOD1 ^@ http://purl.uniprot.org/uniprot/M3WA01 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/9685:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5G5|||http://purl.uniprot.org/uniprot/A0A2I2UTP6|||http://purl.uniprot.org/uniprot/A0A337SM21|||http://purl.uniprot.org/uniprot/A0A5F5XZX8|||http://purl.uniprot.org/uniprot/M3WSP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/9685:CRAT ^@ http://purl.uniprot.org/uniprot/A0A2I2UP24|||http://purl.uniprot.org/uniprot/A0A5F5Y5C0 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9685:NTF3 ^@ http://purl.uniprot.org/uniprot/Q9TST2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/9685:GGT5 ^@ http://purl.uniprot.org/uniprot/M3X9T7 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9685:CLDN20 ^@ http://purl.uniprot.org/uniprot/M3VXB2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9685:TMEM225B ^@ http://purl.uniprot.org/uniprot/M3X2H5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:THOC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKV7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THOC2 family.|||Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.|||Nucleus http://togogenome.org/gene/9685:LOC105260533 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQ24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TMEM129 ^@ http://purl.uniprot.org/uniprot/M3WRD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/9685:TRPM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3X7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RAD17 ^@ http://purl.uniprot.org/uniprot/A0A5F5XX94|||http://purl.uniprot.org/uniprot/M3VYL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/9685:SRD5A2 ^@ http://purl.uniprot.org/uniprot/M3WDH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/9685:BBS7 ^@ http://purl.uniprot.org/uniprot/M3X7G4 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/9685:BCL7B ^@ http://purl.uniprot.org/uniprot/M3X7M8 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9685:GSTA4 ^@ http://purl.uniprot.org/uniprot/A0A2I2URN5 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9685:LOC101084959 ^@ http://purl.uniprot.org/uniprot/M3XAW8 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:POT1 ^@ http://purl.uniprot.org/uniprot/M3X4B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/9685:LOC101090518 ^@ http://purl.uniprot.org/uniprot/M3WBX2 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9685:POLR3D ^@ http://purl.uniprot.org/uniprot/M3W3X4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SLCO1A2 ^@ http://purl.uniprot.org/uniprot/M3WPM9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:FAM83C ^@ http://purl.uniprot.org/uniprot/M3W5W6 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/9685:PREPL ^@ http://purl.uniprot.org/uniprot/M3VV38 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9685:PIF1 ^@ http://purl.uniprot.org/uniprot/M3WEX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.|||Mitochondrion|||Monomer. Interacts with telomerase.|||Nucleus http://togogenome.org/gene/9685:LOC101101667 ^@ http://purl.uniprot.org/uniprot/M3WW05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GREM2 ^@ http://purl.uniprot.org/uniprot/M3W3X3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:RASGRP3 ^@ http://purl.uniprot.org/uniprot/M3WBU3 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9685:PDE6C ^@ http://purl.uniprot.org/uniprot/M3X4Y4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:F2R ^@ http://purl.uniprot.org/uniprot/M3W050 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PIWIL4 ^@ http://purl.uniprot.org/uniprot/M3WE65 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/9685:SLC25A12 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9X6|||http://purl.uniprot.org/uniprot/A0A2I2ULF4|||http://purl.uniprot.org/uniprot/A0A337SL15|||http://purl.uniprot.org/uniprot/M3W360 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:SLC12A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9685:CD1H11orf1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3E3|||http://purl.uniprot.org/uniprot/A0A337SVQ2 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9685:PORCN ^@ http://purl.uniprot.org/uniprot/A0A337S7I9|||http://purl.uniprot.org/uniprot/A0A337SGW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RDH16 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y323|||http://purl.uniprot.org/uniprot/M3WKX4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:PHB1 ^@ http://purl.uniprot.org/uniprot/A8WA76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:AKR1D1 ^@ http://purl.uniprot.org/uniprot/M3W615 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9685:GDI1 ^@ http://purl.uniprot.org/uniprot/M3WF17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/9685:SENP8 ^@ http://purl.uniprot.org/uniprot/M3VV62 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9685:PLOD1 ^@ http://purl.uniprot.org/uniprot/M3VU17 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9685:NUP85 ^@ http://purl.uniprot.org/uniprot/M3WKU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9685:CES5A ^@ http://purl.uniprot.org/uniprot/Q8I034 ^@ Developmental Stage|||Function|||Induction|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the type-B carboxylesterase/lipase family.|||Carboxylesterase present at high level in urine that regulates production of felinine, a probable pheromone precursor. Probably acts by hydrolyzing the peptide bond of the felinine precursor 3-methylbutanol cyteinylglycine, producing felinine and glycine in cat urine.|||N-glycosylated; contains a fucosylated complex carbohydrate.|||Present at high level in urine. Expressed in the kidney proximal straight tubular cells and is secreted from the apical compartment of the cells into the urine (at protein level). In mature cats, it is present at higher level in intact males than in castrated males or in intact or spayed females.|||Present in cats older than about 3 months, and its level increases with age.|||Protein specifically present in urine of cat. Present at high level in urine of members of the genus Felis and Lynx but not in urine of other felines.|||Secreted|||Strongly down-regulated in cats suffering from tubulointerstitial nephritis (TIN). Excretion decreases immediately after castration. http://togogenome.org/gene/9685:CD4 ^@ http://purl.uniprot.org/uniprot/P79355 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:VPS37A ^@ http://purl.uniprot.org/uniprot/A0A5F5XNT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9685:TSPAN33 ^@ http://purl.uniprot.org/uniprot/M3WKW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:DSG4 ^@ http://purl.uniprot.org/uniprot/M3WTD0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9685:NCSTN ^@ http://purl.uniprot.org/uniprot/A0A337S9P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nicastrin family.|||Membrane http://togogenome.org/gene/9685:GPHN ^@ http://purl.uniprot.org/uniprot/A0A5F5XH93|||http://purl.uniprot.org/uniprot/M3WIY2 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.|||In the C-terminal section; belongs to the MoeA family.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9685:NAV3 ^@ http://purl.uniprot.org/uniprot/A0A337SN55 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/9685:IL-29 ^@ http://purl.uniprot.org/uniprot/Q1JUL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9685:PHF5A ^@ http://purl.uniprot.org/uniprot/M3W0S1 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/9685:GGA3 ^@ http://purl.uniprot.org/uniprot/A0A337S3F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9685:TAX1BP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8E9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.|||Nucleus http://togogenome.org/gene/9685:OSGEP ^@ http://purl.uniprot.org/uniprot/M3W6S4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:GABRG3 ^@ http://purl.uniprot.org/uniprot/M3X5P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:NUDT7 ^@ http://purl.uniprot.org/uniprot/M3WTY8 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9685:UBA5 ^@ http://purl.uniprot.org/uniprot/M3XFJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Endoplasmic reticulum membrane|||Golgi apparatus http://togogenome.org/gene/9685:PEX5 ^@ http://purl.uniprot.org/uniprot/M3VU88 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9685:LOC101098401 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:THBS1 ^@ http://purl.uniprot.org/uniprot/M3WF45 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:PARP6 ^@ http://purl.uniprot.org/uniprot/M3WYA9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9685:LOC101086178 ^@ http://purl.uniprot.org/uniprot/M3WSP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GALNT2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:ARAF ^@ http://purl.uniprot.org/uniprot/M3X071 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/9685:FTSJ1 ^@ http://purl.uniprot.org/uniprot/M3XEN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/9685:SLC40A1 ^@ http://purl.uniprot.org/uniprot/M3W7S0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/9685:LOC101097294 ^@ http://purl.uniprot.org/uniprot/M3X9B4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:POLR2B ^@ http://purl.uniprot.org/uniprot/A0A337SUE0 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9685:SLC4A4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UF62 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9685:DZIP1L ^@ http://purl.uniprot.org/uniprot/M3WL84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||cilium basal body http://togogenome.org/gene/9685:FUT8 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0C4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9685:CILP2 ^@ http://purl.uniprot.org/uniprot/M3WKI3 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9685:GPR158 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:MAB21L1 ^@ http://purl.uniprot.org/uniprot/M3WXW7 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9685:SLC35A1 ^@ http://purl.uniprot.org/uniprot/M3X514 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:KATNAL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0H9 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9685:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/A0A337SG88 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9685:TM4SF1 ^@ http://purl.uniprot.org/uniprot/M3WJF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9685:ABCA1 ^@ http://purl.uniprot.org/uniprot/M3W217 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC101089293 ^@ http://purl.uniprot.org/uniprot/A0A5F5XX01 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MMP27 ^@ http://purl.uniprot.org/uniprot/M3WN99 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:MPP4 ^@ http://purl.uniprot.org/uniprot/A0A337ST83|||http://purl.uniprot.org/uniprot/M3W1D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM237 family.|||Component of the transition zone in primary cilia. Required for ciliogenesis.|||Membrane|||cilium http://togogenome.org/gene/9685:PPM1A ^@ http://purl.uniprot.org/uniprot/A0A337SV75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/9685:GOT1 ^@ http://purl.uniprot.org/uniprot/M3X6W4 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9685:B3GNT9 ^@ http://purl.uniprot.org/uniprot/A0A337SF10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:TOE1 ^@ http://purl.uniprot.org/uniprot/A0A2I2URP1 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9685:HOXD10 ^@ http://purl.uniprot.org/uniprot/M3W5K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9685:OPN1SW ^@ http://purl.uniprot.org/uniprot/F7VJP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Photoreceptor inner segment|||photoreceptor outer segment http://togogenome.org/gene/9685:RIN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V415 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9685:KCNA1 ^@ http://purl.uniprot.org/uniprot/M3W515 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:CHRM5 ^@ http://purl.uniprot.org/uniprot/M3WUP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9685:IL12B ^@ http://purl.uniprot.org/uniprot/O02744 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).|||Belongs to the IL-12B family.|||Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).|||Secreted http://togogenome.org/gene/9685:EIF4A1 ^@ http://purl.uniprot.org/uniprot/M3XBC3 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9685:ENKUR ^@ http://purl.uniprot.org/uniprot/A0A2I2USE4 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9685:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/M3WSS0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:FAR2 ^@ http://purl.uniprot.org/uniprot/M3VUC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9685:MMS19 ^@ http://purl.uniprot.org/uniprot/M3WIU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MET18/MMS19 family.|||Component of the CIA complex.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus|||spindle http://togogenome.org/gene/9685:ATP6V1F ^@ http://purl.uniprot.org/uniprot/A0A337SJT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9685:UTS2R ^@ http://purl.uniprot.org/uniprot/Q533H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/9685:KEF43_p09 ^@ http://purl.uniprot.org/uniprot/P48896 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).|||Mitochondrion membrane http://togogenome.org/gene/9685:LOC101082181 ^@ http://purl.uniprot.org/uniprot/M3XG50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ZFP69 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVI9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:OLFML3 ^@ http://purl.uniprot.org/uniprot/M3WB23 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:ABCA8 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4Z4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:JPH3 ^@ http://purl.uniprot.org/uniprot/M3W9G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/9685:BMT2 ^@ http://purl.uniprot.org/uniprot/M3WUQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9685:CLDN12 ^@ http://purl.uniprot.org/uniprot/M3X2V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/9685:ADPRM ^@ http://purl.uniprot.org/uniprot/M3W1A4 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/9685:THOC5 ^@ http://purl.uniprot.org/uniprot/M3W1U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/9685:MED11 ^@ http://purl.uniprot.org/uniprot/A0A2I2U581 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:COX11 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXD4 ^@ Function|||Subcellular Location Annotation ^@ Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:TRMT112 ^@ http://purl.uniprot.org/uniprot/M3WWU1 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/9685:CCR5 ^@ http://purl.uniprot.org/uniprot/Q867D6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:FNTB ^@ http://purl.uniprot.org/uniprot/M3XEV7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.|||Heterodimer of FNTA and FNTB. http://togogenome.org/gene/9685:LOC101082738 ^@ http://purl.uniprot.org/uniprot/M3W7G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:KCND2 ^@ http://purl.uniprot.org/uniprot/M3W8J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/9685:PPP1CC ^@ http://purl.uniprot.org/uniprot/M3WEL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9685:SNRPE ^@ http://purl.uniprot.org/uniprot/A0A2I2UMK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9685:AGPAT4 ^@ http://purl.uniprot.org/uniprot/M3VUL5 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9685:LOC101096974 ^@ http://purl.uniprot.org/uniprot/M3WVQ9 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9685:GCK ^@ http://purl.uniprot.org/uniprot/A3EYB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9685:MAP2K3 ^@ http://purl.uniprot.org/uniprot/M3WZ01 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:CA9 ^@ http://purl.uniprot.org/uniprot/A0A337S4C7 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9685:ISCA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/9685:HHEX ^@ http://purl.uniprot.org/uniprot/M3WU79 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:MCIDAS ^@ http://purl.uniprot.org/uniprot/A0A2I2V4P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9685:TFEC ^@ http://purl.uniprot.org/uniprot/A0A5F5XT41|||http://purl.uniprot.org/uniprot/M3WXG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9685:STC1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y3A1|||http://purl.uniprot.org/uniprot/M3WZL9 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9685:HBM ^@ http://purl.uniprot.org/uniprot/M3WAU3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues. http://togogenome.org/gene/9685:IL1F10 ^@ http://purl.uniprot.org/uniprot/A0A2I2U952 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9685:CLN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UD38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9685:CPNE1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V326 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9685:MOSPD3 ^@ http://purl.uniprot.org/uniprot/M3W6L0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PLA2G1B ^@ http://purl.uniprot.org/uniprot/A0A2I2ULG3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9685:ABCA4 ^@ http://purl.uniprot.org/uniprot/M3WMS4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:FOXN3 ^@ http://purl.uniprot.org/uniprot/M3WHW5 ^@ Function|||Subcellular Location Annotation ^@ Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|||Nucleus http://togogenome.org/gene/9685:TRIQK ^@ http://purl.uniprot.org/uniprot/A0A337S547 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:PPP1R3C ^@ http://purl.uniprot.org/uniprot/M3WBI3 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/9685:GPR34 ^@ http://purl.uniprot.org/uniprot/A0A5F5XBZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Orphan receptor. http://togogenome.org/gene/9685:LRCH1 ^@ http://purl.uniprot.org/uniprot/P41737 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.|||Cytoplasm|||Interacts (via LRR repeats) with unphosphorylated DOCK8 (via DHR-2 domain); the interaction prevents the interaction between DOCK8 and CDC42. http://togogenome.org/gene/9685:XPO7 ^@ http://purl.uniprot.org/uniprot/M3WAJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:GDNF ^@ http://purl.uniprot.org/uniprot/A0A2I2ULX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9685:CDKN2AIPNL ^@ http://purl.uniprot.org/uniprot/A0A2I2UUV8 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9685:OTOP3 ^@ http://purl.uniprot.org/uniprot/M3VVS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:UTP11 ^@ http://purl.uniprot.org/uniprot/M3WEC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9685:CCDC39 ^@ http://purl.uniprot.org/uniprot/M3WQK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC39 family.|||cilium axoneme http://togogenome.org/gene/9685:SQSTM1 ^@ http://purl.uniprot.org/uniprot/M3WL63 ^@ Subcellular Location Annotation ^@ Lysosome|||autophagosome http://togogenome.org/gene/9685:LOC101101393 ^@ http://purl.uniprot.org/uniprot/M3X1G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CB3H15orf65 ^@ http://purl.uniprot.org/uniprot/A0A2I2UMS5 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9685:EXOC6 ^@ http://purl.uniprot.org/uniprot/M3X6I4 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9685:PDIK1L ^@ http://purl.uniprot.org/uniprot/M3WZD8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:STX12 ^@ http://purl.uniprot.org/uniprot/M3X2I4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9685:LOC100302541 ^@ http://purl.uniprot.org/uniprot/C5NM74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:PERP ^@ http://purl.uniprot.org/uniprot/M3WY23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9685:LOC101095775 ^@ http://purl.uniprot.org/uniprot/A0A2I2U6H5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/M3VYG4 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/9685:CC1H1orf52 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYD1 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/9685:HK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9685:KEF43_p06 ^@ http://purl.uniprot.org/uniprot/A0A7D5UF19|||http://purl.uniprot.org/uniprot/P48912 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9685:PAMR1 ^@ http://purl.uniprot.org/uniprot/M3W4X3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:DDX3X ^@ http://purl.uniprot.org/uniprot/M3WY95 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9685:PSMB7 ^@ http://purl.uniprot.org/uniprot/M3WKX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:MRPS11 ^@ http://purl.uniprot.org/uniprot/M3WLP4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9685:MAPK8 ^@ http://purl.uniprot.org/uniprot/A0A2I2V255 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9685:NOL10 ^@ http://purl.uniprot.org/uniprot/M3WB31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9685:SEC22C ^@ http://purl.uniprot.org/uniprot/M3X626 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9685:ITGA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UF78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9685:ACKR1 ^@ http://purl.uniprot.org/uniprot/A0A337S1Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/9685:SLC29A2 ^@ http://purl.uniprot.org/uniprot/M3WNX6 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9685:DUSP10 ^@ http://purl.uniprot.org/uniprot/M3WM38 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9685:MINDY3 ^@ http://purl.uniprot.org/uniprot/A0A337S3N9|||http://purl.uniprot.org/uniprot/M3WYA2 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9685:DENR ^@ http://purl.uniprot.org/uniprot/A0A2I2UPJ8 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/9685:VDAC2 ^@ http://purl.uniprot.org/uniprot/M3X2J1 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9685:TMEM245 ^@ http://purl.uniprot.org/uniprot/M3WE82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/9685:SLC7A11 ^@ http://purl.uniprot.org/uniprot/M3W0X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SEC11C ^@ http://purl.uniprot.org/uniprot/A0A2I2UK96 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:FUNDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9685:LCTL ^@ http://purl.uniprot.org/uniprot/M3WGP3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/9685:MRPL41 ^@ http://purl.uniprot.org/uniprot/M3W0L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/9685:SCN3B ^@ http://purl.uniprot.org/uniprot/M3VUR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9685:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A337S1J0 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9685:PHC1 ^@ http://purl.uniprot.org/uniprot/M3WMA6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:GRID2 ^@ http://purl.uniprot.org/uniprot/A0A337SF47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9685:DEFB134 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9685:SGF29 ^@ http://purl.uniprot.org/uniprot/M3WGP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:DKK3 ^@ http://purl.uniprot.org/uniprot/A0A1E1FFM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9685:PIPOX ^@ http://purl.uniprot.org/uniprot/M3W6Z7 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/9685:APH1A ^@ http://purl.uniprot.org/uniprot/M3XG97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9685:TGM6 ^@ http://purl.uniprot.org/uniprot/M3WKQ7 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9685:SMDT1 ^@ http://purl.uniprot.org/uniprot/M3VVL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:AQP9 ^@ http://purl.uniprot.org/uniprot/M3XBC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101100332 ^@ http://purl.uniprot.org/uniprot/M3WX64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:URM1 ^@ http://purl.uniprot.org/uniprot/M3W4T2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm http://togogenome.org/gene/9685:CLK1 ^@ http://purl.uniprot.org/uniprot/A0A337SR13 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:LOC101085745 ^@ http://purl.uniprot.org/uniprot/M3WPV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NFE2L2 ^@ http://purl.uniprot.org/uniprot/M3WGE7 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9685:HEXB ^@ http://purl.uniprot.org/uniprot/P49614 ^@ Activity Regulation|||Disease Annotation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2.|||Belongs to the glycosyl hydrolase 20 family.|||Cortical granule|||Defects in HEXB are responsible for Sandhoff disease (GM2-gangliosidosis type-II). This disorder is found in Korat cats (initially imported from Thailand).|||Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity).|||Lysosome|||There are 3 forms of beta-hexosaminidase: hexosaminidase A is an heterodimer composed of one subunit alpha and one subunit beta (chain A and B); hexosaminidase B is an homodimer of two beta subunits (two chains A and B); hexosaminidase S is a homodimer of two alpha subunits (By similarity). The composition of the dimer (isozyme A versus isozyme S) has a significant effect on the substrate specificity of the alpha subunit active site (By similarity). http://togogenome.org/gene/9685:TARS2 ^@ http://purl.uniprot.org/uniprot/A0A337SK33 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:ADGRG1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XTA5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/9685:DIMT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQG6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/9685:LSM7 ^@ http://purl.uniprot.org/uniprot/M3W0C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/9685:RAD54L2 ^@ http://purl.uniprot.org/uniprot/M3WP42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/9685:CASP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIE2|||http://purl.uniprot.org/uniprot/A0A5F5XGT3 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9685:SLC8A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4E2|||http://purl.uniprot.org/uniprot/A0A5F5XU70|||http://purl.uniprot.org/uniprot/M3WBP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101081211 ^@ http://purl.uniprot.org/uniprot/M3WXK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NME7 ^@ http://purl.uniprot.org/uniprot/M3WB88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9685:CLRN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9685:ITGB1 ^@ http://purl.uniprot.org/uniprot/P53713 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity).|||Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner (By similarity). Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with MYO10. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with DAB2. Interacts with FGR and HCK. Isoform 2 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 2 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has a heterodimer form (By similarity). ITGA5:ITGB1 interacts with CCN3 (By similarity). ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (By similarity). ITGA5:ITGB1 interacts with FBN1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 interacts with IL1B. Interacts with MDK. ITGA4:ITGB1 interacts with MDK; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation. ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite-outgrowth (By similarity). ITGA5:ITGB1 interacts with ACE2 (By similarity). Interacts with TMEM182 and LAMB1 (By similarity). Interacts with tensin TNS3; TNS3 also interacts with PEAK1, thus acting as an adapter molecule to bridge the association of PEAK1 with ITGB1 (By similarity). Interacts with tensin TNS4; the interaction displaces tensin TNS3 from the ITGB1 cytoplasmic tail and promotes ITGB1 stability (By similarity).|||Melanosome|||Recycling endosome|||The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle|||ruffle membrane http://togogenome.org/gene/9685:MFN2 ^@ http://purl.uniprot.org/uniprot/M3VU19 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:SMG8 ^@ http://purl.uniprot.org/uniprot/M3WIN9 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. http://togogenome.org/gene/9685:SUCNR1 ^@ http://purl.uniprot.org/uniprot/M3X921 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:LOC101094321 ^@ http://purl.uniprot.org/uniprot/A0A5F5XJY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:IRF4 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3D7|||http://purl.uniprot.org/uniprot/M3XD58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ARPC2 ^@ http://purl.uniprot.org/uniprot/M3VYD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton|||synaptosome http://togogenome.org/gene/9685:ST8SIA3 ^@ http://purl.uniprot.org/uniprot/M3WEJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:HPSE2 ^@ http://purl.uniprot.org/uniprot/A0A337SDJ3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9685:CRHR1 ^@ http://purl.uniprot.org/uniprot/A0A337SCM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.|||Membrane http://togogenome.org/gene/9685:IFT57 ^@ http://purl.uniprot.org/uniprot/M3WTC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9685:COG1 ^@ http://purl.uniprot.org/uniprot/M3W2Q9 ^@ Similarity ^@ Belongs to the COG1 family. http://togogenome.org/gene/9685:CLCC1 ^@ http://purl.uniprot.org/uniprot/M3WE17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane http://togogenome.org/gene/9685:LOC101100421 ^@ http://purl.uniprot.org/uniprot/A0A5F5XWS7|||http://purl.uniprot.org/uniprot/M3XDZ0 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/9685:NFS1 ^@ http://purl.uniprot.org/uniprot/A0A337SAK4|||http://purl.uniprot.org/uniprot/M3VZZ3 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/9685:IFNG ^@ http://purl.uniprot.org/uniprot/A9UKW5|||http://purl.uniprot.org/uniprot/P46402 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.|||Released primarily from activated T lymphocytes.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. http://togogenome.org/gene/9685:PROKR1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9C0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:VPS4B ^@ http://purl.uniprot.org/uniprot/M3WXF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9685:CLPS ^@ http://purl.uniprot.org/uniprot/A0A337SLF4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/9685:CACNG2 ^@ http://purl.uniprot.org/uniprot/M3WZA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/9685:RAB19 ^@ http://purl.uniprot.org/uniprot/A0A2I2U841 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9685:IQCG ^@ http://purl.uniprot.org/uniprot/M3WNK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC9 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9685:HNF4G ^@ http://purl.uniprot.org/uniprot/M3X5S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9685:NFXL1 ^@ http://purl.uniprot.org/uniprot/M3WQV3 ^@ Similarity ^@ Belongs to the NFX1 family. http://togogenome.org/gene/9685:PDE6G ^@ http://purl.uniprot.org/uniprot/P61248 ^@ Function|||Similarity|||Subunit ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (By similarity). http://togogenome.org/gene/9685:DNAJC2 ^@ http://purl.uniprot.org/uniprot/M3VV50 ^@ Function|||Subcellular Location Annotation ^@ Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.|||cytosol http://togogenome.org/gene/9685:B4GALT3 ^@ http://purl.uniprot.org/uniprot/M3WN80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9685:CAD ^@ http://purl.uniprot.org/uniprot/A0A2I2U188|||http://purl.uniprot.org/uniprot/A0A2I2UTI8 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/9685:MTMR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V2L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9685:ZFP69B ^@ http://purl.uniprot.org/uniprot/A0A2I2V2F3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:GADL1 ^@ http://purl.uniprot.org/uniprot/M3XB58 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9685:LOC101085947 ^@ http://purl.uniprot.org/uniprot/A0A5F5XF81 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Binds strongly to apatite and calcium.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Secreted http://togogenome.org/gene/9685:LPGAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZZ0 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9685:CD14 ^@ http://purl.uniprot.org/uniprot/M3VWC6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.|||Cell membrane|||Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).|||Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/9685:ATG12 ^@ http://purl.uniprot.org/uniprot/M3W807 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/9685:SLC30A2 ^@ http://purl.uniprot.org/uniprot/A0A337SHT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9685:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U200|||http://purl.uniprot.org/uniprot/A0A2I2UJQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9685:DTX3 ^@ http://purl.uniprot.org/uniprot/M3VXV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9685:DYNC1LI1 ^@ http://purl.uniprot.org/uniprot/M3W8M1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/9685:CSF2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MPY1|||http://purl.uniprot.org/uniprot/A9UKW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/9685:FUNDC2 ^@ http://purl.uniprot.org/uniprot/M3X325 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9685:GRIK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4F7|||http://purl.uniprot.org/uniprot/A0A2I2U739|||http://purl.uniprot.org/uniprot/A0A337S2R5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9685:CLCN2 ^@ http://purl.uniprot.org/uniprot/A0A337SIW0|||http://purl.uniprot.org/uniprot/A0A5F5XF95|||http://purl.uniprot.org/uniprot/M3W8E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:CDADC1 ^@ http://purl.uniprot.org/uniprot/A0A337S248 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/9685:KRT39 ^@ http://purl.uniprot.org/uniprot/M3VXR5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:LOC101095395 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2F0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/9685:DGAT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVU3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CLRN2 ^@ http://purl.uniprot.org/uniprot/M3VZ81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9685:IL1A ^@ http://purl.uniprot.org/uniprot/O46613 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated within its nuclear localization sequence, which impacts subcellular localization.|||Belongs to the IL-1 family.|||Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.|||Cytoplasm|||Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.|||Nucleus|||Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.|||Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.|||Secreted|||The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. http://togogenome.org/gene/9685:LOC101083005 ^@ http://purl.uniprot.org/uniprot/M3X726 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:MPL ^@ http://purl.uniprot.org/uniprot/M3WLY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Membrane http://togogenome.org/gene/9685:LOC101087114 ^@ http://purl.uniprot.org/uniprot/M3WK40 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1R0|||http://purl.uniprot.org/uniprot/A0A2I2U302|||http://purl.uniprot.org/uniprot/A0A2I2UPZ5|||http://purl.uniprot.org/uniprot/A0A337SAV3|||http://purl.uniprot.org/uniprot/M3WZB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9685:IFNA7 ^@ http://purl.uniprot.org/uniprot/P35849 ^@ Function|||Pharmaceutical|||Similarity|||Subcellular Location Annotation ^@ Available under the names Virbagen Omega and Intercat. Used in veterinary medicine to treat canine parvovirus, feline leukemia virus and feline immunodeficiency virus infections.|||Belongs to the alpha/beta interferon family.|||Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.|||Secreted http://togogenome.org/gene/9685:MEIG1 ^@ http://purl.uniprot.org/uniprot/M3X8F5 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9685:NRXN1 ^@ http://purl.uniprot.org/uniprot/M3X6J8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Presynaptic cell membrane http://togogenome.org/gene/9685:PTGER4 ^@ http://purl.uniprot.org/uniprot/A0A2I2URK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9685:FABP7 ^@ http://purl.uniprot.org/uniprot/M3W635 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9685:CENPJ ^@ http://purl.uniprot.org/uniprot/A0A5F5Y7Z8|||http://purl.uniprot.org/uniprot/M3W339 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/9685:NDUFB7 ^@ http://purl.uniprot.org/uniprot/M3WIY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9685:FHIP1A ^@ http://purl.uniprot.org/uniprot/M3X351 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/9685:IRF3 ^@ http://purl.uniprot.org/uniprot/M3W582 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHZ6|||http://purl.uniprot.org/uniprot/A0A337S0B1|||http://purl.uniprot.org/uniprot/A0A5F5XKI9|||http://purl.uniprot.org/uniprot/M3WE59 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:LOC101092875 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5A3 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:GLIS2 ^@ http://purl.uniprot.org/uniprot/M3WEP8 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9685:KCNK16 ^@ http://purl.uniprot.org/uniprot/M3W5V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9685:DUS4L ^@ http://purl.uniprot.org/uniprot/M3W2R5 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/9685:TEKT5 ^@ http://purl.uniprot.org/uniprot/M3WCB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9685:DOLPP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9C2|||http://purl.uniprot.org/uniprot/M3W4W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/9685:LPCAT4 ^@ http://purl.uniprot.org/uniprot/M3VX71 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9685:CPSF7 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/9685:PLCD1 ^@ http://purl.uniprot.org/uniprot/A0A337SD30 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/9685:LOC101080967 ^@ http://purl.uniprot.org/uniprot/M3W6J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:EPS8L1 ^@ http://purl.uniprot.org/uniprot/M3X4X2 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9685:LOC109498816 ^@ http://purl.uniprot.org/uniprot/A0A337SA79 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9685:SMIM18 ^@ http://purl.uniprot.org/uniprot/M3WVL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ADCYAP1R1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UK30|||http://purl.uniprot.org/uniprot/A0A337SH77|||http://purl.uniprot.org/uniprot/A0A337SPS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:VWC2L ^@ http://purl.uniprot.org/uniprot/A0A337S692 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9685:CDH12 ^@ http://purl.uniprot.org/uniprot/M3W8Q0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101080845 ^@ http://purl.uniprot.org/uniprot/M3X0X3 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:LOC101093971 ^@ http://purl.uniprot.org/uniprot/M3WJI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PPP4C ^@ http://purl.uniprot.org/uniprot/M3WK76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9685:KAT7 ^@ http://purl.uniprot.org/uniprot/M3VYV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9685:UQCC3 ^@ http://purl.uniprot.org/uniprot/M3X8X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCC3 family.|||Membrane|||Mitochondrion inner membrane|||Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. http://togogenome.org/gene/9685:SMARCA1 ^@ http://purl.uniprot.org/uniprot/A0A337S5J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/9685:AFF4 ^@ http://purl.uniprot.org/uniprot/M3WGX3 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9685:BMP15 ^@ http://purl.uniprot.org/uniprot/C7EWM2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9685:PRPF19 ^@ http://purl.uniprot.org/uniprot/M3WJ97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9685:LOXL2 ^@ http://purl.uniprot.org/uniprot/M3WGV4 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9685:INTS12 ^@ http://purl.uniprot.org/uniprot/M3WSY3 ^@ Similarity|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. http://togogenome.org/gene/9685:FN3KRP ^@ http://purl.uniprot.org/uniprot/M3WFV8 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9685:LOC102901968 ^@ http://purl.uniprot.org/uniprot/M3WY24 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9685:PIM2 ^@ http://purl.uniprot.org/uniprot/M3X0B0 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9685:MAT2A ^@ http://purl.uniprot.org/uniprot/M3WG37 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9685:EPS8 ^@ http://purl.uniprot.org/uniprot/M3WSY6 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9685:TMEM198 ^@ http://purl.uniprot.org/uniprot/M3W6A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9685:MFF ^@ http://purl.uniprot.org/uniprot/A0A337S3V7|||http://purl.uniprot.org/uniprot/A0A5F5XSR9|||http://purl.uniprot.org/uniprot/A0A5F5XU69|||http://purl.uniprot.org/uniprot/M3WCN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.|||synaptic vesicle http://togogenome.org/gene/9685:GRM1 ^@ http://purl.uniprot.org/uniprot/M3WDB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A2I2V2F2|||http://purl.uniprot.org/uniprot/M3WSG5 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9685:LOC101086420 ^@ http://purl.uniprot.org/uniprot/M3WWP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:EXOC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/9685:LOC101083202 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0B2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ZSCAN20 ^@ http://purl.uniprot.org/uniprot/A0A337SMY7 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9685:RECQL ^@ http://purl.uniprot.org/uniprot/M3WQ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9685:FZD4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UH80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:ZNF202 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEW4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:FNIP1 ^@ http://purl.uniprot.org/uniprot/A0A337S3G6|||http://purl.uniprot.org/uniprot/M3X2R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9685:TRAF1 ^@ http://purl.uniprot.org/uniprot/M3X9B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9685:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULQ8|||http://purl.uniprot.org/uniprot/A0A2I2V1N8|||http://purl.uniprot.org/uniprot/A0A337S1Y9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9685:LOC101083287 ^@ http://purl.uniprot.org/uniprot/M3X1C9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ERGIC2 ^@ http://purl.uniprot.org/uniprot/M3WNL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9685:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/M3XCI9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:LACTB2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XCK9 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/9685:PRORP ^@ http://purl.uniprot.org/uniprot/M3W232 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/9685:FA2H ^@ http://purl.uniprot.org/uniprot/M3WM14 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:IL19 ^@ http://purl.uniprot.org/uniprot/M3W5Z2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9685:LOC102902259 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZ56 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9685:UTP15 ^@ http://purl.uniprot.org/uniprot/M3X7S6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9685:PIGC ^@ http://purl.uniprot.org/uniprot/M3XAC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9685:PDE4C ^@ http://purl.uniprot.org/uniprot/A0A2I2V4E3|||http://purl.uniprot.org/uniprot/A0A337SH66|||http://purl.uniprot.org/uniprot/M3W7V5 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:N4BP3 ^@ http://purl.uniprot.org/uniprot/M3X8L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Vesicle|||dendrite http://togogenome.org/gene/9685:FCF1 ^@ http://purl.uniprot.org/uniprot/M3XA89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/9685:IL2RA ^@ http://purl.uniprot.org/uniprot/P41690 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit (By similarity).|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/9685:RPA3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UN78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/9685:CD63 ^@ http://purl.uniprot.org/uniprot/Q76B49 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Cell surface|||Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity).|||Interacts with TIMP1 and ITGB1 and recruits TIMP1 to ITGB1. Interacts with CD9. Identified in a complex with CD9 and ITGB3. Interacts with PMEL. Interacts with KDR/VEGFR2; identified in a complex with ITGB1 and KDR/VEGFR2 and is required to recruit KDR to ITGB1 complexes. Interacts with SYT7 (By similarity).|||Late endosome membrane|||Lysosome membrane|||Melanosome|||Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro) (By similarity).|||extracellular exosome|||multivesicular body http://togogenome.org/gene/9685:CCDC47 ^@ http://purl.uniprot.org/uniprot/M3X4U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9685:LOC101087098 ^@ http://purl.uniprot.org/uniprot/M3X3F9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:AP1M2 ^@ http://purl.uniprot.org/uniprot/M3W1V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9685:DNPH1 ^@ http://purl.uniprot.org/uniprot/M3WBZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.|||Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.|||Cytoplasm|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/9685:WDR18 ^@ http://purl.uniprot.org/uniprot/A0A5F5XRD8|||http://purl.uniprot.org/uniprot/M3W7H8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat IPI3/WDR18 family.|||Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.|||Cytoplasm|||Dynein axonemal particle|||Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9685:SLC39A12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UA85|||http://purl.uniprot.org/uniprot/A0A337SUJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9685:ARAP3 ^@ http://purl.uniprot.org/uniprot/M3XBA3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:LSM4 ^@ http://purl.uniprot.org/uniprot/M3W8L3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9685:CBR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm http://togogenome.org/gene/9685:L3MBTL2 ^@ http://purl.uniprot.org/uniprot/M3W0R6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Nucleus|||Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.|||Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. http://togogenome.org/gene/9685:GAB2 ^@ http://purl.uniprot.org/uniprot/M3W7R8 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9685:PRLR ^@ http://purl.uniprot.org/uniprot/A0A2I2U3Q9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/9685:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A2I2U3W0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. http://togogenome.org/gene/9685:IDH3A ^@ http://purl.uniprot.org/uniprot/M3WDF0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9685:LOC101085313 ^@ http://purl.uniprot.org/uniprot/M3X1Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:HMGCR ^@ http://purl.uniprot.org/uniprot/A0A2I2UV66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9685:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9685:PRKCI ^@ http://purl.uniprot.org/uniprot/M3XF13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9685:SCPEP1 ^@ http://purl.uniprot.org/uniprot/M3WQ85 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9685:OTX2 ^@ http://purl.uniprot.org/uniprot/M3X072 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9685:RPLP2 ^@ http://purl.uniprot.org/uniprot/M3W9K1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9685:GPR179 ^@ http://purl.uniprot.org/uniprot/M3W4R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:GTDC1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNU9 ^@ Similarity ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. http://togogenome.org/gene/9685:RFC4 ^@ http://purl.uniprot.org/uniprot/M3WJN5 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9685:TNS4 ^@ http://purl.uniprot.org/uniprot/M3WBU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9685:FAAH ^@ http://purl.uniprot.org/uniprot/M3W0D6 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9685:LOC101088278 ^@ http://purl.uniprot.org/uniprot/M3XGB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MCCC2 ^@ http://purl.uniprot.org/uniprot/M3WJQ5 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/9685:FUBP1 ^@ http://purl.uniprot.org/uniprot/A0A337S9W3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CRLS1 ^@ http://purl.uniprot.org/uniprot/M3WV79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9685:AQP11 ^@ http://purl.uniprot.org/uniprot/M3W7R2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:TLR1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XZ29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane|||Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. http://togogenome.org/gene/9685:LOC101100398 ^@ http://purl.uniprot.org/uniprot/A0A337S8G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GAL3ST1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3T8 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9685:GALR1 ^@ http://purl.uniprot.org/uniprot/M3WA11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9685:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A337S3N4|||http://purl.uniprot.org/uniprot/M3W017 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9685:FLNB ^@ http://purl.uniprot.org/uniprot/A0A2I2US09|||http://purl.uniprot.org/uniprot/A0A2I2UUW4|||http://purl.uniprot.org/uniprot/M3W620 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9685:PARP16 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4V7 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9685:CA2 ^@ http://purl.uniprot.org/uniprot/M3W3J4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9685:FGF19 ^@ http://purl.uniprot.org/uniprot/A0A2I2V549 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9685:BAAT ^@ http://purl.uniprot.org/uniprot/M3WV30 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9685:OPN4 ^@ http://purl.uniprot.org/uniprot/Q5YKK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Cell membrane|||Eye. Expression is restricted within the ganglion cell layer.|||Perikaryon|||Photoreceptor that binds cis-retinaldehydes (By similarity). Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light (By similarity). May be involved in the optokinetic visual tracking response (By similarity). May be involved in the regulation of retinal hyaloid vessel growth and regression (By similarity).|||axon|||dendrite http://togogenome.org/gene/9685:BMP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9685:SMPDL3B ^@ http://purl.uniprot.org/uniprot/M3W0A7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/9685:MCL1 ^@ http://purl.uniprot.org/uniprot/Q7YRZ9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Bcl-2 family.|||Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment.|||Cytoplasm|||Interacts with HIF3A (via C-terminus domain) (By similarity). Interacts with BOK, BIK, BAX, BAK1, and TPT1. Interacts with unphosphorylated BAD (By similarity). Interacts with BMF, BBC3 and PMAIP1 (By similarity). Interacts with BOP (By similarity). Interacts with BCL2L11; may sequester BCL2L11 to prevent its pro-apoptotic activity (By similarity). Interacts with GIMAP5 and HSPA8/HSC70; the interaction between HSPA8 and MCL1 is impaired in the absence of GIMAP5 (By similarity).|||Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity).|||Membrane|||Mitochondrion|||Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites (By similarity).|||Rapidly degraded in the absence of phosphorylation in the PEST region.|||Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159 (By similarity). Deubiquitinated by USP20; leading to increased stability.|||nucleoplasm http://togogenome.org/gene/9685:NCAPG ^@ http://purl.uniprot.org/uniprot/M3X3A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/9685:PLAT ^@ http://purl.uniprot.org/uniprot/A0A2I2UP76 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:CNTF ^@ http://purl.uniprot.org/uniprot/A0A2I2UWM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/9685:IFT46 ^@ http://purl.uniprot.org/uniprot/M3WFS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/9685:RBM22 ^@ http://purl.uniprot.org/uniprot/M3WPJ5 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/9685:AFF1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XXG3 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/9685:MCM4 ^@ http://purl.uniprot.org/uniprot/M3WF03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9685:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4K4|||http://purl.uniprot.org/uniprot/A0A337S8W5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9685:UNC45B ^@ http://purl.uniprot.org/uniprot/M3VUD5 ^@ Subcellular Location Annotation ^@ A band|||Z line|||perinuclear region http://togogenome.org/gene/9685:EMC4 ^@ http://purl.uniprot.org/uniprot/M3VX67 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:RPE ^@ http://purl.uniprot.org/uniprot/M3WAV5 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/9685:KRT19 ^@ http://purl.uniprot.org/uniprot/M3VXK3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:RND3 ^@ http://purl.uniprot.org/uniprot/M3X4I5 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/9685:GAL3ST4 ^@ http://purl.uniprot.org/uniprot/M3X9U2 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9685:MCM7 ^@ http://purl.uniprot.org/uniprot/A0A337S3U9|||http://purl.uniprot.org/uniprot/M3W0J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9685:PRRC1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XRL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/9685:RPL26 ^@ http://purl.uniprot.org/uniprot/M3WES0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9685:IL6 ^@ http://purl.uniprot.org/uniprot/P41683 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).|||Belongs to the IL-6 superfamily.|||Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.|||Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.|||IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).|||Secreted http://togogenome.org/gene/9685:LOC101100666 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MYADM ^@ http://purl.uniprot.org/uniprot/M3WYP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9685:MLLT11 ^@ http://purl.uniprot.org/uniprot/M3WVR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/9685:CNOT3 ^@ http://purl.uniprot.org/uniprot/M3WJZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT2/3/5 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.|||Nucleus|||P-body http://togogenome.org/gene/9685:KIN ^@ http://purl.uniprot.org/uniprot/M3VU97 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9685:CXXC5 ^@ http://purl.uniprot.org/uniprot/M3WDF6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:IYD ^@ http://purl.uniprot.org/uniprot/A0A337SF28 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:DDT ^@ http://purl.uniprot.org/uniprot/M3WBD6 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9685:CPSF2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9685:LAMA2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHA4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/9685:SLC25A32 ^@ http://purl.uniprot.org/uniprot/M3W3C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:LOC101099914 ^@ http://purl.uniprot.org/uniprot/M3X2Q3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:POGLUT2 ^@ http://purl.uniprot.org/uniprot/M3W1S1 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9685:CLIC1 ^@ http://purl.uniprot.org/uniprot/M3WNY6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Endoplasmic reticulum|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9685:RPL10L ^@ http://purl.uniprot.org/uniprot/M3WLF1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9685:LOC101085206 ^@ http://purl.uniprot.org/uniprot/M3X700 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:TSPAN6 ^@ http://purl.uniprot.org/uniprot/M3W038 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:PLA2G5 ^@ http://purl.uniprot.org/uniprot/M3W328 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9685:GDF11 ^@ http://purl.uniprot.org/uniprot/M3WSH4 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9685:MTX3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4U1|||http://purl.uniprot.org/uniprot/A0A337SKE3|||http://purl.uniprot.org/uniprot/M3W146 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9685:LOC101083761 ^@ http://purl.uniprot.org/uniprot/M3WPB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ABR ^@ http://purl.uniprot.org/uniprot/A0A2I2URF9|||http://purl.uniprot.org/uniprot/A0A337S856 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/9685:LTN1 ^@ http://purl.uniprot.org/uniprot/M3WJC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/9685:RPL21 ^@ http://purl.uniprot.org/uniprot/A0A5K1UH56 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9685:EMP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3X9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/9685:CHGB ^@ http://purl.uniprot.org/uniprot/M3VUB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/9685:MAN1A2 ^@ http://purl.uniprot.org/uniprot/M3WPE4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9685:TMA16 ^@ http://purl.uniprot.org/uniprot/M3X5D1 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9685:LOC101100752 ^@ http://purl.uniprot.org/uniprot/A0A337SWS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:FAM53C ^@ http://purl.uniprot.org/uniprot/M3VX53 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9685:LOC101101283 ^@ http://purl.uniprot.org/uniprot/A0A5F5XXM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:MMP16 ^@ http://purl.uniprot.org/uniprot/M3WTU5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:LOC101101581 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCT5|||http://purl.uniprot.org/uniprot/M3W589 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Belongs to the ADP-ribosylglycohydrolase family.|||Secreted http://togogenome.org/gene/9685:ANO2 ^@ http://purl.uniprot.org/uniprot/M3W6M2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:PADI1 ^@ http://purl.uniprot.org/uniprot/M3WCU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9685:MPI ^@ http://purl.uniprot.org/uniprot/A0A337SGZ2|||http://purl.uniprot.org/uniprot/A0A5F5XIZ8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9685:KIF4A ^@ http://purl.uniprot.org/uniprot/M3W9X8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:VGLL1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y2U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/9685:LOC101100535 ^@ http://purl.uniprot.org/uniprot/A0A337SQR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ABL1 ^@ http://purl.uniprot.org/uniprot/M3W3H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9685:ATP1B1 ^@ http://purl.uniprot.org/uniprot/M3WB86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9685:HSD17B2 ^@ http://purl.uniprot.org/uniprot/M3W394 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:MYORG ^@ http://purl.uniprot.org/uniprot/M3WY70 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9685:PGAP1 ^@ http://purl.uniprot.org/uniprot/A0A337SUT7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:NIM1K ^@ http://purl.uniprot.org/uniprot/M3WG46 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:HYAL2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y3D4|||http://purl.uniprot.org/uniprot/M3W6X5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9685:RGS4 ^@ http://purl.uniprot.org/uniprot/M3X000 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9685:CENPA ^@ http://purl.uniprot.org/uniprot/A0A337SKR6 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/9685:CCT3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V532 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9685:POLR2K ^@ http://purl.uniprot.org/uniprot/M3VXF4 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9685:RTN3 ^@ http://purl.uniprot.org/uniprot/M3WQJ1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:RPL8 ^@ http://purl.uniprot.org/uniprot/M3WRT2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9685:CFB ^@ http://purl.uniprot.org/uniprot/M3W2B8 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:MRRF ^@ http://purl.uniprot.org/uniprot/A0A337SQR8 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9685:SF3B3 ^@ http://purl.uniprot.org/uniprot/M3WBJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:MARVELD3 ^@ http://purl.uniprot.org/uniprot/A0A337SP56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:FRZB ^@ http://purl.uniprot.org/uniprot/M3WJ69 ^@ Caution|||Function|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/9685:RSPO3 ^@ http://purl.uniprot.org/uniprot/M3WAW8 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9685:MGST1 ^@ http://purl.uniprot.org/uniprot/M3WUX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9685:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9685:PPIL2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UX72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/9685:HOXB13 ^@ http://purl.uniprot.org/uniprot/M3VXX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9685:SOAT1 ^@ http://purl.uniprot.org/uniprot/M3W8J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:GSDMC ^@ http://purl.uniprot.org/uniprot/M3W6U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101097701 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9685:CNDP2 ^@ http://purl.uniprot.org/uniprot/M3W9A2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9685:BRMS1L ^@ http://purl.uniprot.org/uniprot/M3WQI1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101083444 ^@ http://purl.uniprot.org/uniprot/M3WJY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:TIMM10 ^@ http://purl.uniprot.org/uniprot/A0A2I2U515 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9685:ATM ^@ http://purl.uniprot.org/uniprot/A0A2I2U0F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily.|||Cytoplasmic vesicle|||Nucleus|||Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks. http://togogenome.org/gene/9685:NGRN ^@ http://purl.uniprot.org/uniprot/M3X9U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neugrin family.|||Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.|||Mitochondrion membrane|||Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. http://togogenome.org/gene/9685:PSMD1 ^@ http://purl.uniprot.org/uniprot/A0A337SSW7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9685:TM4SF19 ^@ http://purl.uniprot.org/uniprot/M3W839 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9685:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/M3WQM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9685:DLG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPF7|||http://purl.uniprot.org/uniprot/A0A2I2UWT1|||http://purl.uniprot.org/uniprot/A0A337SAJ6|||http://purl.uniprot.org/uniprot/A0A337SSR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:VPS25 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFC7 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/9685:RAB5IF ^@ http://purl.uniprot.org/uniprot/A0A337S247|||http://purl.uniprot.org/uniprot/M3X6D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:UBE4A ^@ http://purl.uniprot.org/uniprot/A0A5K1TTU0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9685:DPY30 ^@ http://purl.uniprot.org/uniprot/M3X6U1 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9685:TMEM9B ^@ http://purl.uniprot.org/uniprot/A0A2I2U282 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9685:MOCS3 ^@ http://purl.uniprot.org/uniprot/M3X4P1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 zinc ion per subunit.|||Cytoplasm|||In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.|||Interacts with NFS1.|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. http://togogenome.org/gene/9685:NUTF2 ^@ http://purl.uniprot.org/uniprot/M3X0F5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9685:LOC101085956 ^@ http://purl.uniprot.org/uniprot/A0A2I2US12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/M3W8X9 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9685:PLAA ^@ http://purl.uniprot.org/uniprot/M3XEX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PLAP family.|||Cytoplasm http://togogenome.org/gene/9685:TMEM225 ^@ http://purl.uniprot.org/uniprot/M3W3A1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ADHFE1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XEU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/9685:DDX52 ^@ http://purl.uniprot.org/uniprot/M3WDI8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/9685:CLEC16A ^@ http://purl.uniprot.org/uniprot/M3WFI8 ^@ Similarity ^@ Belongs to the CLEC16A/gop-1 family. http://togogenome.org/gene/9685:LOC101080380 ^@ http://purl.uniprot.org/uniprot/M3WZ13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:UBE2H ^@ http://purl.uniprot.org/uniprot/M3WTA4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9685:LOC101101336 ^@ http://purl.uniprot.org/uniprot/M3X5C3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:BARHL2 ^@ http://purl.uniprot.org/uniprot/M3X0Z3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ADAMTS3 ^@ http://purl.uniprot.org/uniprot/M3W363 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9685:PSPH ^@ http://purl.uniprot.org/uniprot/A0A337SAC2|||http://purl.uniprot.org/uniprot/M3WT54 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/9685:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V1I2|||http://purl.uniprot.org/uniprot/M3W9N6 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9685:NRP2 ^@ http://purl.uniprot.org/uniprot/M3VUQ9 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:GSTM3 ^@ http://purl.uniprot.org/uniprot/M3WMX0 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/9685:MRPS17 ^@ http://purl.uniprot.org/uniprot/A0A337SE92 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9685:TTC30B ^@ http://purl.uniprot.org/uniprot/M3X6J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/9685:MAPK6 ^@ http://purl.uniprot.org/uniprot/M3WH68 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9685:KLHL3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XHH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KLHL3 family.|||cytoskeleton|||cytosol http://togogenome.org/gene/9685:CDK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCH2|||http://purl.uniprot.org/uniprot/A0A2I2UFY5|||http://purl.uniprot.org/uniprot/A0A2I2V4K7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:SERPINA12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UZ95 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:CA1H5orf22 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULY9 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9685:ST3GAL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:GSG1 ^@ http://purl.uniprot.org/uniprot/A0A337S925|||http://purl.uniprot.org/uniprot/A0A337SMC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9685:PGAM2 ^@ http://purl.uniprot.org/uniprot/M3WYZ8 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9685:ID3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKX0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/M3VW28 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9685:BHMT ^@ http://purl.uniprot.org/uniprot/M3XCT4 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9685:LOC101083065 ^@ http://purl.uniprot.org/uniprot/M3WVM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ANXA2 ^@ http://purl.uniprot.org/uniprot/A0A337SCD2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.|||Membrane|||basement membrane http://togogenome.org/gene/9685:ACSF2 ^@ http://purl.uniprot.org/uniprot/M3WGR0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:LOC101080990 ^@ http://purl.uniprot.org/uniprot/A0A337RTK2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9685:TMEM121B ^@ http://purl.uniprot.org/uniprot/A0A5F5XVV8 ^@ Similarity ^@ Belongs to the TMEM121 family. http://togogenome.org/gene/9685:CYP2D6 ^@ http://purl.uniprot.org/uniprot/E0D568 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9685:SNUPN ^@ http://purl.uniprot.org/uniprot/A0A2I2U2N7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snurportin family.|||Cytoplasm|||Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.|||Nucleus http://togogenome.org/gene/9685:HSPA2 ^@ http://purl.uniprot.org/uniprot/M3W8G1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9685:PPEF2 ^@ http://purl.uniprot.org/uniprot/M3W5Y3 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9685:MRPS21 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQC7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9685:PTPRM ^@ http://purl.uniprot.org/uniprot/A0A5F5XET7|||http://purl.uniprot.org/uniprot/A0A5F5XFK5|||http://purl.uniprot.org/uniprot/M3WI26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:ZP1 ^@ http://purl.uniprot.org/uniprot/I6M4H3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Zona pellucida http://togogenome.org/gene/9685:COQ3 ^@ http://purl.uniprot.org/uniprot/M3WNZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/9685:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8T1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9685:RHBDD3 ^@ http://purl.uniprot.org/uniprot/M3W1U2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LSM5 ^@ http://purl.uniprot.org/uniprot/M3X1T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/9685:INKA1 ^@ http://purl.uniprot.org/uniprot/M3WDQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9685:MAB21L2 ^@ http://purl.uniprot.org/uniprot/M3X8D1 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9685:SLC25A18 ^@ http://purl.uniprot.org/uniprot/M3W8X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:OXTR ^@ http://purl.uniprot.org/uniprot/M3WL83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9685:GATA1 ^@ http://purl.uniprot.org/uniprot/M3WE57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LAMP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3S9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9685:USP30 ^@ http://purl.uniprot.org/uniprot/M3W9F1 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9685:MRPL17 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8T0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/9685:CPPED1 ^@ http://purl.uniprot.org/uniprot/M3WUY1 ^@ Function|||Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family.|||Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. http://togogenome.org/gene/9685:TAF12 ^@ http://purl.uniprot.org/uniprot/M3WQ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/9685:LOC101095915 ^@ http://purl.uniprot.org/uniprot/M3WRZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC102899713 ^@ http://purl.uniprot.org/uniprot/A0A5F5XEP4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:ASPA ^@ http://purl.uniprot.org/uniprot/M3X3I5 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9685:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A2I2U469|||http://purl.uniprot.org/uniprot/M3VXI5 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9685:COX7A2L ^@ http://purl.uniprot.org/uniprot/A0A2I2UF99 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9685:LOC101096683 ^@ http://purl.uniprot.org/uniprot/M3XFB6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:NDUFS3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U833 ^@ Similarity ^@ Belongs to the complex I 30 kDa subunit family. http://togogenome.org/gene/9685:CHST12 ^@ http://purl.uniprot.org/uniprot/A0A5F5XE15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYU3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:AKT3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XEI1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:TUB ^@ http://purl.uniprot.org/uniprot/M3VVA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9685:HOXB5 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9685:CCT2 ^@ http://purl.uniprot.org/uniprot/M3VWY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9685:VRK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0C2|||http://purl.uniprot.org/uniprot/M3W988 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:CCR1 ^@ http://purl.uniprot.org/uniprot/B6DXF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9685:ACAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2V1T1 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/9685:CYP2E1 ^@ http://purl.uniprot.org/uniprot/Q5KR51 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.|||Membrane|||Microsome membrane|||Mitochondrion inner membrane|||The omega-1 hydroxylase activity is stimulated by cytochrome b5. http://togogenome.org/gene/9685:LOC105260530 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:BEX2 ^@ http://purl.uniprot.org/uniprot/M3W135 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9685:TMEM126B ^@ http://purl.uniprot.org/uniprot/A0A2I2UF27|||http://purl.uniprot.org/uniprot/A0A337SSC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ACYP2 ^@ http://purl.uniprot.org/uniprot/A0A337S1E5 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9685:ATP5MK ^@ http://purl.uniprot.org/uniprot/M3VYE9 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/9685:CD36 ^@ http://purl.uniprot.org/uniprot/M3WZ55 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9685:EIF6 ^@ http://purl.uniprot.org/uniprot/M3W5W5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/9685:UNC45A ^@ http://purl.uniprot.org/uniprot/M3W599 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/9685:TMEM178B ^@ http://purl.uniprot.org/uniprot/A0A337SJL4 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9685:KCNJ2 ^@ http://purl.uniprot.org/uniprot/K4LND8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9685:WNT2 ^@ http://purl.uniprot.org/uniprot/A0M8T2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||extracellular matrix http://togogenome.org/gene/9685:ADNP ^@ http://purl.uniprot.org/uniprot/M3XE38 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101083543 ^@ http://purl.uniprot.org/uniprot/M3WCM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:KCNJ11 ^@ http://purl.uniprot.org/uniprot/M3W7H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/9685:MED30 ^@ http://purl.uniprot.org/uniprot/M3X2K5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9685:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2URL8|||http://purl.uniprot.org/uniprot/A0A337SBU2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9685:GPR182 ^@ http://purl.uniprot.org/uniprot/A0A5F5XV40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101100726 ^@ http://purl.uniprot.org/uniprot/M3XA47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:FAM136A ^@ http://purl.uniprot.org/uniprot/A0A2I2U9R2 ^@ Similarity ^@ Belongs to the FAM136 family. http://togogenome.org/gene/9685:LOC101093722 ^@ http://purl.uniprot.org/uniprot/A0A5F5XRU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DUSP4 ^@ http://purl.uniprot.org/uniprot/M3X8R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9685:BEX5 ^@ http://purl.uniprot.org/uniprot/M3WI51 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9685:ZSCAN16 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y1L6|||http://purl.uniprot.org/uniprot/M3W0N4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ARG2 ^@ http://purl.uniprot.org/uniprot/M3WK19 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9685:NPC1 ^@ http://purl.uniprot.org/uniprot/Q9N0Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9685:ENO3 ^@ http://purl.uniprot.org/uniprot/M3VX63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9685:ADSS2 ^@ http://purl.uniprot.org/uniprot/A0A2I2URN8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/9685:RETREG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2URS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:TNFSF8 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYN0 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9685:ABT1 ^@ http://purl.uniprot.org/uniprot/M3X6Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||nucleolus http://togogenome.org/gene/9685:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A337S5B6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9685:TAFA4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXN6 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9685:PPP1CB ^@ http://purl.uniprot.org/uniprot/M3XDH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9685:GDE1 ^@ http://purl.uniprot.org/uniprot/M3XBX5 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9685:DCPS ^@ http://purl.uniprot.org/uniprot/A0A2I2UCB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/9685:LOC102902042 ^@ http://purl.uniprot.org/uniprot/A0A5F5XPA5 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9685:PFDN5 ^@ http://purl.uniprot.org/uniprot/A0A337S850 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/9685:LAMTOR1 ^@ http://purl.uniprot.org/uniprot/M3W3V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9685:ORC6 ^@ http://purl.uniprot.org/uniprot/M3XG01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9685:ENO2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9685:VAC14 ^@ http://purl.uniprot.org/uniprot/M3W3Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Endosome membrane|||Microsome membrane http://togogenome.org/gene/9685:FBP1 ^@ http://purl.uniprot.org/uniprot/M3WB78 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/9685:SEMA4F ^@ http://purl.uniprot.org/uniprot/A0A2I2UFC3|||http://purl.uniprot.org/uniprot/A0A337SKM0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:KCNK17 ^@ http://purl.uniprot.org/uniprot/M3XBT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9685:RNF111 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Arkadia family.|||PML body http://togogenome.org/gene/9685:SNRPN ^@ http://purl.uniprot.org/uniprot/M3WVH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9685:SERPINB3 ^@ http://purl.uniprot.org/uniprot/M3W9H3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:EFNB1 ^@ http://purl.uniprot.org/uniprot/M3WR70 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:AMIGO2 ^@ http://purl.uniprot.org/uniprot/M3VWT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SOHLH2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0C1|||http://purl.uniprot.org/uniprot/A0A5F5XRZ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ALG11 ^@ http://purl.uniprot.org/uniprot/M3X9F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/9685:CNKSR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5T2 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9685:SELL ^@ http://purl.uniprot.org/uniprot/A2V6R9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selectin/LECAM family.|||Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.|||Cell membrane|||Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:LOC101093877 ^@ http://purl.uniprot.org/uniprot/M3WX35 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9685:ELOVL7 ^@ http://purl.uniprot.org/uniprot/M3WJ50 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9685:SLC25A39 ^@ http://purl.uniprot.org/uniprot/A0A2I2UC92 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:SKAP2 ^@ http://purl.uniprot.org/uniprot/M3WRR0 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9685:RBX1 ^@ http://purl.uniprot.org/uniprot/M3X867 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9685:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A2I2V3E5|||http://purl.uniprot.org/uniprot/M3VUM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:DYNLL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UY49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9685:TEFM ^@ http://purl.uniprot.org/uniprot/M3WUU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TEFM family.|||Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.|||mitochondrion nucleoid http://togogenome.org/gene/9685:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4C8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:HSPB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UD88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small heat shock protein (HSP20) family.|||Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.|||Cytoplasm|||Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.|||Nucleus http://togogenome.org/gene/9685:SLC41A2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y3S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9685:ELL ^@ http://purl.uniprot.org/uniprot/M3WC08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9685:EFTUD2 ^@ http://purl.uniprot.org/uniprot/M3W441 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:NFIA ^@ http://purl.uniprot.org/uniprot/A0A337SGT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9685:MIF ^@ http://purl.uniprot.org/uniprot/M3W1I3 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9685:EMC6 ^@ http://purl.uniprot.org/uniprot/M3W8M7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:RRAGB ^@ http://purl.uniprot.org/uniprot/M3WJR9|||http://purl.uniprot.org/uniprot/M3X5P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9685:ZFYVE16 ^@ http://purl.uniprot.org/uniprot/M3X9A9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/9685:CLTRN ^@ http://purl.uniprot.org/uniprot/A0A2I2UW73 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:INSM2 ^@ http://purl.uniprot.org/uniprot/M3XFK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CYFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7Z7 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/9685:TIMP4 ^@ http://purl.uniprot.org/uniprot/M3XCK0 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9685:INTS14 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/9685:CLTB ^@ http://purl.uniprot.org/uniprot/A0A2I2UNI9|||http://purl.uniprot.org/uniprot/M3X8N5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9685:LOC101084446 ^@ http://purl.uniprot.org/uniprot/M3X6T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:ATP7A ^@ http://purl.uniprot.org/uniprot/M3WS99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9685:MRPL53 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/9685:PPP1R12B ^@ http://purl.uniprot.org/uniprot/A0A337S3Q2|||http://purl.uniprot.org/uniprot/A0A5F5Y2T4 ^@ Subcellular Location Annotation ^@ stress fiber http://togogenome.org/gene/9685:SF3A3 ^@ http://purl.uniprot.org/uniprot/M3XB41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3A3 family.|||Nucleus http://togogenome.org/gene/9685:CPSF4 ^@ http://purl.uniprot.org/uniprot/A0A337RX23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9685:C3AR1 ^@ http://purl.uniprot.org/uniprot/M3WTC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9685:PPP3CA ^@ http://purl.uniprot.org/uniprot/A0A2I2UWL3|||http://purl.uniprot.org/uniprot/A0A337RZJ8 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9685:SERINC2 ^@ http://purl.uniprot.org/uniprot/A0A337S134 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9685:SLC5A2 ^@ http://purl.uniprot.org/uniprot/M3VWJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:APOH ^@ http://purl.uniprot.org/uniprot/M3WH75 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:ACOX2 ^@ http://purl.uniprot.org/uniprot/M3VY35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9685:TLR8 ^@ http://purl.uniprot.org/uniprot/B2BE52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9685:CCM2 ^@ http://purl.uniprot.org/uniprot/A0A337SQK1 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/9685:RPS13 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4A9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9685:VKORC1 ^@ http://purl.uniprot.org/uniprot/M3WW90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:CCN3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UV24 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:STX11 ^@ http://purl.uniprot.org/uniprot/A0A2I2V2Y9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9685:LXN ^@ http://purl.uniprot.org/uniprot/M3WIL4 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/9685:LOC101091280 ^@ http://purl.uniprot.org/uniprot/M3X6T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:CACNG6 ^@ http://purl.uniprot.org/uniprot/A0A337SLV0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. http://togogenome.org/gene/9685:LOC101090388 ^@ http://purl.uniprot.org/uniprot/M3WYC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CDC25A ^@ http://purl.uniprot.org/uniprot/A0A2I2UB12|||http://purl.uniprot.org/uniprot/M3WA86 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9685:PER1 ^@ http://purl.uniprot.org/uniprot/M3WM49 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:TIMP3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAQ8 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9685:CDH1 ^@ http://purl.uniprot.org/uniprot/A0A337SG59 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:ANXA7 ^@ http://purl.uniprot.org/uniprot/M3W9B7 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9685:ZNF274 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y3C6|||http://purl.uniprot.org/uniprot/M3X6Y2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ESYT1 ^@ http://purl.uniprot.org/uniprot/M3WLH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:KIF3A ^@ http://purl.uniprot.org/uniprot/M3WJY9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:CNOT9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/9685:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A337S2K4|||http://purl.uniprot.org/uniprot/M3XD60 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9685:RPS27A ^@ http://purl.uniprot.org/uniprot/M3WWF6 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/9685:NXPH4 ^@ http://purl.uniprot.org/uniprot/M3X0B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9685:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7U6|||http://purl.uniprot.org/uniprot/A0A5F5Y5Y0 ^@ Similarity|||Subunit ^@ Belongs to the CCNDBP1 family.|||Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. http://togogenome.org/gene/9685:NKX2-8 ^@ http://purl.uniprot.org/uniprot/M3VVV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:FOXI1 ^@ http://purl.uniprot.org/uniprot/M3VVI1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:NUDC ^@ http://purl.uniprot.org/uniprot/M3WHP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/9685:LOC101096314 ^@ http://purl.uniprot.org/uniprot/M3WZR5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:TMEM265 ^@ http://purl.uniprot.org/uniprot/A0A2I2UG28 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9685:FITM1 ^@ http://purl.uniprot.org/uniprot/M3W4B5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. FIT1 subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol. http://togogenome.org/gene/9685:PRRT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U136 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9685:RAPSN ^@ http://purl.uniprot.org/uniprot/M3VYP7 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/9685:CRY1 ^@ http://purl.uniprot.org/uniprot/M3XE84 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9685:TRIM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U851 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9685:LOC101083026 ^@ http://purl.uniprot.org/uniprot/M3XBD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TLR2 ^@ http://purl.uniprot.org/uniprot/M3X0I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane http://togogenome.org/gene/9685:NQO2 ^@ http://purl.uniprot.org/uniprot/M3X0S5 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9685:SMPD1 ^@ http://purl.uniprot.org/uniprot/M3X374 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/9685:SLC6A17 ^@ http://purl.uniprot.org/uniprot/M3W3K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9685:KEF43_p04 ^@ http://purl.uniprot.org/uniprot/P48916 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:PRR15L ^@ http://purl.uniprot.org/uniprot/A0A5F5Y299 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9685:NFX1 ^@ http://purl.uniprot.org/uniprot/M3WS67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/9685:LOC101080399 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCA7 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9685:HPS6 ^@ http://purl.uniprot.org/uniprot/A0A5F5XUW1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||Microsome membrane http://togogenome.org/gene/9685:DHX9 ^@ http://purl.uniprot.org/uniprot/A0A337SGK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/9685:BRMS1 ^@ http://purl.uniprot.org/uniprot/M3WB72 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101101352 ^@ http://purl.uniprot.org/uniprot/M3WH90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IGFL family.|||Secreted http://togogenome.org/gene/9685:LOC105259999 ^@ http://purl.uniprot.org/uniprot/M3XEZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:STRIP2 ^@ http://purl.uniprot.org/uniprot/M3WSE1 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/9685:VPS35 ^@ http://purl.uniprot.org/uniprot/M3VWJ8 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/9685:OSBPL5 ^@ http://purl.uniprot.org/uniprot/M3W6T5 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9685:ACTA2 ^@ http://purl.uniprot.org/uniprot/M3W7A1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:FTL ^@ http://purl.uniprot.org/uniprot/Q2MHN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ferritin family.|||Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). http://togogenome.org/gene/9685:MTIF2 ^@ http://purl.uniprot.org/uniprot/M3WJ66 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9685:ENSA ^@ http://purl.uniprot.org/uniprot/M3X3H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9685:DOCK2 ^@ http://purl.uniprot.org/uniprot/M3VVI0 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9685:RRAGA ^@ http://purl.uniprot.org/uniprot/M3X4R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9685:EGF ^@ http://purl.uniprot.org/uniprot/Q95ND4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).|||Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD) (By similarity). Interacts with RHBDF2 (By similarity).|||Membrane http://togogenome.org/gene/9685:HOMER1 ^@ http://purl.uniprot.org/uniprot/M3WN77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9685:SYNGR4 ^@ http://purl.uniprot.org/uniprot/M3VVR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9685:OOEP ^@ http://purl.uniprot.org/uniprot/Q06VW1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity). Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity).|||Belongs to the KHDC1 family.|||Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3, OOEP, and TLE6 (By similarity). Within the complex, interacts with NLRP5, KHDC3 and TLE6 (By similarity). As part of the SCMC interacts with the SCMC-associated protein NLRP4F (By similarity). The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments (By similarity). Forms a scaffold complex with KHDC3/FILIA, and interacts with BLM and TRIM25 at DNA replication forks (By similarity).|||Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:TSPO2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/9685:PDCD10 ^@ http://purl.uniprot.org/uniprot/M3X9Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:KLC2 ^@ http://purl.uniprot.org/uniprot/M3W1P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9685:GABRA1 ^@ http://purl.uniprot.org/uniprot/M3W913 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:LOC101083729 ^@ http://purl.uniprot.org/uniprot/A0A5F5XKZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/9685:OPLAH ^@ http://purl.uniprot.org/uniprot/M3WFA2 ^@ Similarity ^@ Belongs to the oxoprolinase family. http://togogenome.org/gene/9685:TGM1 ^@ http://purl.uniprot.org/uniprot/M3W4C6 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9685:ADTRP ^@ http://purl.uniprot.org/uniprot/M3WAX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9685:LOC101090642 ^@ http://purl.uniprot.org/uniprot/M3X6F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PTER ^@ http://purl.uniprot.org/uniprot/M3WJ23 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:MRPS33 ^@ http://purl.uniprot.org/uniprot/M3X647 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9685:PPM1L ^@ http://purl.uniprot.org/uniprot/M3X458 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9685:LOC101084283 ^@ http://purl.uniprot.org/uniprot/M3X403 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DENND5B ^@ http://purl.uniprot.org/uniprot/A0A2I2UXB5|||http://purl.uniprot.org/uniprot/M3W481 ^@ Caution|||Similarity ^@ Belongs to the RAB6IP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LOC101093986 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEY8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9685:WDR12 ^@ http://purl.uniprot.org/uniprot/M3WT89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9685:STK17B ^@ http://purl.uniprot.org/uniprot/M3X7F7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:TMC5 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9685:SPA17 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0R5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9685:XPC ^@ http://purl.uniprot.org/uniprot/A0A5F5XT13|||http://purl.uniprot.org/uniprot/M3VXF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/9685:ACTL6A ^@ http://purl.uniprot.org/uniprot/M3WGS8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9685:SDHAF4 ^@ http://purl.uniprot.org/uniprot/M3WU37 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/9685:CC2H3orf70 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFT7 ^@ Similarity ^@ Belongs to the UPF0524 family. http://togogenome.org/gene/9685:GDF9 ^@ http://purl.uniprot.org/uniprot/C7EWM1|||http://purl.uniprot.org/uniprot/M3WGX0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/9685:TMEM106B ^@ http://purl.uniprot.org/uniprot/M3W5X2 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9685:NSUN3 ^@ http://purl.uniprot.org/uniprot/M3W4Z8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9685:TLR7 ^@ http://purl.uniprot.org/uniprot/A1XC22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Endosome|||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.|||Lysosome|||Membrane|||phagosome http://togogenome.org/gene/9685:RTN2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UI00 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:TRIM21 ^@ http://purl.uniprot.org/uniprot/A0A2I2V321|||http://purl.uniprot.org/uniprot/K7ZLC6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:SLC16A7 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9685:FRG1 ^@ http://purl.uniprot.org/uniprot/M3WRX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/9685:SLC25A35 ^@ http://purl.uniprot.org/uniprot/M3VX23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:PDYN ^@ http://purl.uniprot.org/uniprot/A0A2I2V0Q3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opioid activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9685:CACNB3 ^@ http://purl.uniprot.org/uniprot/M3VU22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9685:GNRHR ^@ http://purl.uniprot.org/uniprot/A0A5K1VGL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9685:SEC31A ^@ http://purl.uniprot.org/uniprot/A0A2I2UE80|||http://purl.uniprot.org/uniprot/A0A2I2V4B0|||http://purl.uniprot.org/uniprot/A0A337SWZ3|||http://purl.uniprot.org/uniprot/M3VWV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:LOC101100753 ^@ http://purl.uniprot.org/uniprot/M3X807 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DIABLO ^@ http://purl.uniprot.org/uniprot/A0A2I2UKG3 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9685:MAGOH ^@ http://purl.uniprot.org/uniprot/M3X9V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9685:LHX9 ^@ http://purl.uniprot.org/uniprot/M3VXC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:FMO3 ^@ http://purl.uniprot.org/uniprot/M3VZK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.|||Membrane|||Microsome membrane http://togogenome.org/gene/9685:ERMN ^@ http://purl.uniprot.org/uniprot/A0A2I2UX21 ^@ Function|||Subunit ^@ Binds actin.|||Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS. http://togogenome.org/gene/9685:LOC102899730 ^@ http://purl.uniprot.org/uniprot/A0A5F5XWR1 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9685:RPL32 ^@ http://purl.uniprot.org/uniprot/M3WW95 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/9685:ERO1B ^@ http://purl.uniprot.org/uniprot/M3W090 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:MSH4 ^@ http://purl.uniprot.org/uniprot/M3WNH7 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/9685:SCN9A ^@ http://purl.uniprot.org/uniprot/A0A337RVZ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9685:PSMC4 ^@ http://purl.uniprot.org/uniprot/M3VVV5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9685:VAMP5 ^@ http://purl.uniprot.org/uniprot/M3WU54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9685:CENPQ ^@ http://purl.uniprot.org/uniprot/M3XB93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-Q/OKP1 family.|||Nucleus http://togogenome.org/gene/9685:RDH10 ^@ http://purl.uniprot.org/uniprot/M3WW26 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:NUCB1 ^@ http://purl.uniprot.org/uniprot/M3W064 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9685:FAXC ^@ http://purl.uniprot.org/uniprot/M3W787 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/9685:MTAP ^@ http://purl.uniprot.org/uniprot/A0A2I2UPB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/9685:SLCO2B1 ^@ http://purl.uniprot.org/uniprot/M3WG20 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:NAMPT ^@ http://purl.uniprot.org/uniprot/M3WY46 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPRTase family.|||Cytoplasm|||Homodimer.|||Nucleus|||Secreted http://togogenome.org/gene/9685:LOC101089514 ^@ http://purl.uniprot.org/uniprot/M3XAW8 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:SAP18 ^@ http://purl.uniprot.org/uniprot/A0A5F5XFM1 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/9685:PTPN12 ^@ http://purl.uniprot.org/uniprot/M3W3N7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. http://togogenome.org/gene/9685:CACHD1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XKT1 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9685:MARVELD2 ^@ http://purl.uniprot.org/uniprot/M3XBR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9685:TREX1 ^@ http://purl.uniprot.org/uniprot/M3X2S3 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/9685:FAM118A ^@ http://purl.uniprot.org/uniprot/A0A2I2UN00 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9685:MMP14 ^@ http://purl.uniprot.org/uniprot/M3W681 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Cytoplasm|||Melanosome http://togogenome.org/gene/9685:TRMT6 ^@ http://purl.uniprot.org/uniprot/M3VZQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/9685:TCN1 ^@ http://purl.uniprot.org/uniprot/M3W7W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9685:TUBA4A ^@ http://purl.uniprot.org/uniprot/A0A2I2UZ20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9685:PML ^@ http://purl.uniprot.org/uniprot/A0A5F5Y353|||http://purl.uniprot.org/uniprot/M3VZQ0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:F13A1 ^@ http://purl.uniprot.org/uniprot/M3WMR4 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9685:FGGY ^@ http://purl.uniprot.org/uniprot/A0A337SGJ6 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9685:EXOC4 ^@ http://purl.uniprot.org/uniprot/M3X5B6 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9685:ZER1 ^@ http://purl.uniprot.org/uniprot/M3W4U4 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9685:HPDL ^@ http://purl.uniprot.org/uniprot/M3X3U1 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9685:GBE1 ^@ http://purl.uniprot.org/uniprot/A0A337SR21|||http://purl.uniprot.org/uniprot/Q6T308 ^@ Disease Annotation|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.|||Binds its carbohydrate substrate close to the active site, but also via regions close to the N-terminus; this may result in increased affinity and therefore increased catalytic efficiency.|||Defects in GBE1 are the cause of glycogen storage disease IV (GSD-IV).|||Monomer.|||Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule. http://togogenome.org/gene/9685:SDC4 ^@ http://purl.uniprot.org/uniprot/M3X6M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Membrane http://togogenome.org/gene/9685:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A2I2UG14|||http://purl.uniprot.org/uniprot/A0A337S7F9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:MFSD3 ^@ http://purl.uniprot.org/uniprot/M3X0S6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:EIF3D ^@ http://purl.uniprot.org/uniprot/M3VW18 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9685:TBRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SLC17A8 ^@ http://purl.uniprot.org/uniprot/M3WNE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ENPEP ^@ http://purl.uniprot.org/uniprot/M3VU18 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Membrane http://togogenome.org/gene/9685:NUP98 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEK3|||http://purl.uniprot.org/uniprot/M3W0W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin GLFG family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9685:GSN ^@ http://purl.uniprot.org/uniprot/M3VZP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the villin/gelsolin family.|||Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X. Interacts with the inactive form of EIF2AK2/PKR.|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.|||cytoskeleton http://togogenome.org/gene/9685:TSC22D4 ^@ http://purl.uniprot.org/uniprot/M3WDY9 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9685:LOC101096808 ^@ http://purl.uniprot.org/uniprot/M3XB45 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:LOC101101260 ^@ http://purl.uniprot.org/uniprot/M3WXH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ANAPC13 ^@ http://purl.uniprot.org/uniprot/M3X5A0 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9685:BAG6 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5J3|||http://purl.uniprot.org/uniprot/A0A337S1C7|||http://purl.uniprot.org/uniprot/A0A337S510 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).|||cytosol|||extracellular exosome http://togogenome.org/gene/9685:SLC17A6 ^@ http://purl.uniprot.org/uniprot/M3WQB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TLR4 ^@ http://purl.uniprot.org/uniprot/P58727 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Toll-like receptor family.|||Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with TICAM2. Interacts with NOX4. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with MAP3K21; this interaction leads to negative regulation of TLR4 signaling. Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR6. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Interacts with TICAM1 in response to LPS in a WDFY1-dependent manner. Interacts with WDFY1 in response to LPS. Interacts with SMPDL3B. Interacts with CEACAM1; upon lipopolysaccharide stimulation, forms a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Interacts with RFTN1; the interaction occurs in response to lipopolysaccharide stimulation. Interacts with SCIMP; the interaction occurs in response to lipopolysaccharide stimulation and is enhanced by phosphorylation of SCIMP by LYN (By similarity). This interaction facilitates the phosphorylation of TLR4 by LYN which elicits a selective cytokine response in macrophages (By similarity). Interacts with TRAF3IP3 (By similarity). Interacts with TREM1; this interaction enhances TLR4-mediated inflammatory response (By similarity).|||Cell membrane|||Early endosome|||In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.|||Phosphorylated on tyrosine residues by LYN after binding lipopolysaccharide.|||The TIR domain mediates interaction with NOX4.|||Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade. In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86. Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway. In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner.|||ruffle http://togogenome.org/gene/9685:SLF2 ^@ http://purl.uniprot.org/uniprot/M3WSC4 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/9685:GSK3A ^@ http://purl.uniprot.org/uniprot/M3X6U4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9685:VSX2 ^@ http://purl.uniprot.org/uniprot/A0A337SVZ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:STX7 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ09|||http://purl.uniprot.org/uniprot/A0A337S3R7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9685:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V2U8|||http://purl.uniprot.org/uniprot/A0A337S4R5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9685:HCCS ^@ http://purl.uniprot.org/uniprot/M3XCQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101080632 ^@ http://purl.uniprot.org/uniprot/M3XAW8 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:CDH18 ^@ http://purl.uniprot.org/uniprot/M3WJ78 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:EPO ^@ http://purl.uniprot.org/uniprot/P33708 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the EPO/TPO family.|||Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.|||Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.|||Secreted http://togogenome.org/gene/9685:FAM183A ^@ http://purl.uniprot.org/uniprot/M3X1B0 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/9685:EEF1G ^@ http://purl.uniprot.org/uniprot/M3WAC5 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/9685:ALDH2 ^@ http://purl.uniprot.org/uniprot/M3X7B5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9685:LOC101088763 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CIAO3 ^@ http://purl.uniprot.org/uniprot/M3W9D4 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9685:COPS4 ^@ http://purl.uniprot.org/uniprot/M3XBM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9685:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWF0|||http://purl.uniprot.org/uniprot/A0A337S4S3|||http://purl.uniprot.org/uniprot/M3XAM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Golgi apparatus membrane|||Midbody|||Mitochondrion outer membrane|||autophagosome membrane http://togogenome.org/gene/9685:LOC101094096 ^@ http://purl.uniprot.org/uniprot/A0A337SE00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9685:PAQR3 ^@ http://purl.uniprot.org/uniprot/M3X871 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9685:RNF141 ^@ http://purl.uniprot.org/uniprot/M3WTE2 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9685:DOLK ^@ http://purl.uniprot.org/uniprot/M3X6P1 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9685:SRP14 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/9685:CTC1 ^@ http://purl.uniprot.org/uniprot/M3VX21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CTC1 family.|||Nucleus|||telomere http://togogenome.org/gene/9685:CORIN ^@ http://purl.uniprot.org/uniprot/M3W5B9 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U2H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9685:GFAP ^@ http://purl.uniprot.org/uniprot/A0A2I2UI95|||http://purl.uniprot.org/uniprot/M3W443 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:NUBP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UA39 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.|||Nucleus|||centrosome http://togogenome.org/gene/9685:PIK3CA ^@ http://purl.uniprot.org/uniprot/A0A2I2UYM7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9685:SLC25A37 ^@ http://purl.uniprot.org/uniprot/M3W411 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:LTB ^@ http://purl.uniprot.org/uniprot/A0A2I2UQ04 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9685:GHITM ^@ http://purl.uniprot.org/uniprot/M3VX10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9685:ATP6V1H ^@ http://purl.uniprot.org/uniprot/M3WKN2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9685:GPKOW ^@ http://purl.uniprot.org/uniprot/M3W112 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MOS2 family.|||Nucleus|||RNA-binding protein involved in pre-mRNA splicing. http://togogenome.org/gene/9685:APOD ^@ http://purl.uniprot.org/uniprot/M3X8P7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Homodimer.|||Secreted http://togogenome.org/gene/9685:LOC101097798 ^@ http://purl.uniprot.org/uniprot/A0A2I2USR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:CAMP ^@ http://purl.uniprot.org/uniprot/F1C962 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9685:CFAP298 ^@ http://purl.uniprot.org/uniprot/M3X8G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/9685:IL15 ^@ http://purl.uniprot.org/uniprot/M3WQ79|||http://purl.uniprot.org/uniprot/O97687 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (By similarity). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity).|||Secreted http://togogenome.org/gene/9685:CXCR4 ^@ http://purl.uniprot.org/uniprot/P56498 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Late endosome|||Lysosome|||Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.|||O- and N-glycosylated. N-glycosylation can mask coreceptor function. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.|||Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-325 and Ser-326 leads to recruitment of ITCH, ubiquitination and protein degradation.|||Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).|||Sulfation is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization.|||Ubiquitinated after ligand binding, leading to its degradation. Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S. http://togogenome.org/gene/9685:COG6 ^@ http://purl.uniprot.org/uniprot/A0A5F5XTZ2|||http://purl.uniprot.org/uniprot/M3WQM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/9685:GABRQ ^@ http://purl.uniprot.org/uniprot/M3W132 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:SASS6 ^@ http://purl.uniprot.org/uniprot/M3X538 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9685:PSMD13 ^@ http://purl.uniprot.org/uniprot/M3VYX6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9685:RHO ^@ http://purl.uniprot.org/uniprot/Q95KU1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.|||Homodimer (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG. Interacts with GNAT1. Interacts with GNAT3. SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability. Forms a complex with ASAP1 and ARF4. Forms a complex with ASAP1, RAB11A, Rabin8/RAB3IP, ARF4 and RAB11FIP3; the complex regulates Golgi-to-cilia rhodopsin/RHO transport in photoreceptors (By similarity).|||Membrane|||Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.|||Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity).|||photoreceptor outer segment http://togogenome.org/gene/9685:KHDC4 ^@ http://purl.uniprot.org/uniprot/A0A337S9E5 ^@ Similarity ^@ Belongs to the KHDC4 family. http://togogenome.org/gene/9685:TOMM22 ^@ http://purl.uniprot.org/uniprot/M3VZ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom22 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9685:SNAPC3 ^@ http://purl.uniprot.org/uniprot/M3VZV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/9685:CCNL1 ^@ http://purl.uniprot.org/uniprot/M3W3J7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/M3WY43 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9685:SLC35E3 ^@ http://purl.uniprot.org/uniprot/M3WKG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:LOC102899058 ^@ http://purl.uniprot.org/uniprot/M3XEQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GRIA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2USC8|||http://purl.uniprot.org/uniprot/A0A2I2UTP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9685:SLC10A2 ^@ http://purl.uniprot.org/uniprot/M3W5V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9685:BHMT2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAZ9 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9685:CACNA2D1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTD9|||http://purl.uniprot.org/uniprot/A0A337SUK1 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9685:DHPS ^@ http://purl.uniprot.org/uniprot/M3VUT7 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/9685:G6PC1 ^@ http://purl.uniprot.org/uniprot/Q19KA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane|||Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. http://togogenome.org/gene/9685:TMPRSS11A ^@ http://purl.uniprot.org/uniprot/M3WXP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9685:SLC7A7 ^@ http://purl.uniprot.org/uniprot/M3X3N4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PCNX3 ^@ http://purl.uniprot.org/uniprot/M3W4I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9685:CFAP97D1 ^@ http://purl.uniprot.org/uniprot/M3X8Y6 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9685:SDHAF2 ^@ http://purl.uniprot.org/uniprot/M3WJA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with SDHA within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. http://togogenome.org/gene/9685:UBE2K ^@ http://purl.uniprot.org/uniprot/A0A2I2UNS7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9685:NKRF ^@ http://purl.uniprot.org/uniprot/M3WA55 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/9685:OVOL1 ^@ http://purl.uniprot.org/uniprot/M3W8L2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:VPS72 ^@ http://purl.uniprot.org/uniprot/M3W4A0 ^@ Function|||Similarity ^@ Belongs to the VPS72/YL1 family.|||Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. http://togogenome.org/gene/9685:GALM ^@ http://purl.uniprot.org/uniprot/M3WQR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. http://togogenome.org/gene/9685:RBBP4 ^@ http://purl.uniprot.org/uniprot/M3WS50 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:AK5 ^@ http://purl.uniprot.org/uniprot/A0A5F5XGD2|||http://purl.uniprot.org/uniprot/M3VWK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/9685:FAIM2 ^@ http://purl.uniprot.org/uniprot/M3WBH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9685:SLC6A16 ^@ http://purl.uniprot.org/uniprot/M3W171 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9685:TRHR ^@ http://purl.uniprot.org/uniprot/M3WD44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9685:CDH10 ^@ http://purl.uniprot.org/uniprot/M3WYR0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:BLK ^@ http://purl.uniprot.org/uniprot/M3WLI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9685:XRCC5 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y0I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus http://togogenome.org/gene/9685:LOC101100947 ^@ http://purl.uniprot.org/uniprot/M3X7H4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9685:UBXN1 ^@ http://purl.uniprot.org/uniprot/M3WAD2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:BPIFC ^@ http://purl.uniprot.org/uniprot/M3WC54 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/9685:ACAA1 ^@ http://purl.uniprot.org/uniprot/M3WHS2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9685:SLC13A1 ^@ http://purl.uniprot.org/uniprot/A0A337SGW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9685:IARS1 ^@ http://purl.uniprot.org/uniprot/M3VVG6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:PNP ^@ http://purl.uniprot.org/uniprot/M3W6S5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/9685:STX5 ^@ http://purl.uniprot.org/uniprot/M3WLB6 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9685:LGMN ^@ http://purl.uniprot.org/uniprot/M3W8K5 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9685:VAMP7 ^@ http://purl.uniprot.org/uniprot/M3X847 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9685:FCGR3A ^@ http://purl.uniprot.org/uniprot/Q9N2I5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Forms a heterooligomeric complex with ITAM-containing signaling subunits FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG.|||Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity). Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity). Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821). http://togogenome.org/gene/9685:IL1RL2 ^@ http://purl.uniprot.org/uniprot/M3WXC8 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9685:SPTAN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UU45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9685:XRCC4 ^@ http://purl.uniprot.org/uniprot/M3X1I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/9685:LOC101084480 ^@ http://purl.uniprot.org/uniprot/M3WEW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SEC23A ^@ http://purl.uniprot.org/uniprot/M3WPR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9685:LOC101089393 ^@ http://purl.uniprot.org/uniprot/A0A2I2U307 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TGFB1I1 ^@ http://purl.uniprot.org/uniprot/M3WAI2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.|||Nucleus matrix|||The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.|||cytoskeleton|||focal adhesion http://togogenome.org/gene/9685:LOC105261319 ^@ http://purl.uniprot.org/uniprot/A0A2I2UE10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:BVES ^@ http://purl.uniprot.org/uniprot/M3W3E1 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9685:CHRNB4 ^@ http://purl.uniprot.org/uniprot/M3VXK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:GLE1 ^@ http://purl.uniprot.org/uniprot/M3W4T5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9685:CACNA1D ^@ http://purl.uniprot.org/uniprot/A0A2I2U2W4|||http://purl.uniprot.org/uniprot/A0A2I2V0N7|||http://purl.uniprot.org/uniprot/A0A337S157|||http://purl.uniprot.org/uniprot/M3W4E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/9685:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/M3WF15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNase I family.|||Nucleus envelope|||Zymogen granule http://togogenome.org/gene/9685:CD4H9orf64 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1N7 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/9685:FMO4 ^@ http://purl.uniprot.org/uniprot/M3WH62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:LOC101091022 ^@ http://purl.uniprot.org/uniprot/M3W226 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9685:GDF3 ^@ http://purl.uniprot.org/uniprot/M3WCE8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9685:LOC101082183 ^@ http://purl.uniprot.org/uniprot/M3WTT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SEMA3A ^@ http://purl.uniprot.org/uniprot/A0A2I2U9R0|||http://purl.uniprot.org/uniprot/A0A2I2UVN1 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SPECC1L ^@ http://purl.uniprot.org/uniprot/M3WWD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/9685:CENPO ^@ http://purl.uniprot.org/uniprot/M3X8I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/9685:HS2ST1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XX19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:SLC25A42 ^@ http://purl.uniprot.org/uniprot/M3WC31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:PKNOX1 ^@ http://purl.uniprot.org/uniprot/A0A337SSN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9685:PRUNE1 ^@ http://purl.uniprot.org/uniprot/M3X7L1 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/9685:SERINC1 ^@ http://purl.uniprot.org/uniprot/M3X6Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9685:ABHD3 ^@ http://purl.uniprot.org/uniprot/M3WQI0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9685:PIAS3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UM51 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9685:RNFT2 ^@ http://purl.uniprot.org/uniprot/M3VVT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TACO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQ26 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/9685:CYBRD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2URT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:IMPG1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XXH0|||http://purl.uniprot.org/uniprot/M3WLK1 ^@ Subcellular Location Annotation ^@ interphotoreceptor matrix http://togogenome.org/gene/9685:ATL1 ^@ http://purl.uniprot.org/uniprot/M3WXA3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9685:SGCD ^@ http://purl.uniprot.org/uniprot/M3WRZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9685:MRPS7 ^@ http://purl.uniprot.org/uniprot/A0A2I2V1J0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9685:SPACA3 ^@ http://purl.uniprot.org/uniprot/A0A077S1K5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9685:KDELR1 ^@ http://purl.uniprot.org/uniprot/M3VVR4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:LOC101082275 ^@ http://purl.uniprot.org/uniprot/M3X0T2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DESI1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWM2 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9685:PRPH ^@ http://purl.uniprot.org/uniprot/M3WLA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||axon http://togogenome.org/gene/9685:CIAO1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1R5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. http://togogenome.org/gene/9685:MYO1C ^@ http://purl.uniprot.org/uniprot/A0A2I2V4A5|||http://purl.uniprot.org/uniprot/M3W5M2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9685:GTF2E2 ^@ http://purl.uniprot.org/uniprot/M3X5G6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/9685:PTGS2 ^@ http://purl.uniprot.org/uniprot/A8QIU4 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:ADGRD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U423|||http://purl.uniprot.org/uniprot/M3WKI7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:SLC2A6 ^@ http://purl.uniprot.org/uniprot/A0A337S6P7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. http://togogenome.org/gene/9685:ADA ^@ http://purl.uniprot.org/uniprot/A0A337S152 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/9685:PROK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UA70|||http://purl.uniprot.org/uniprot/A0A337STJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9685:ATP2A2 ^@ http://purl.uniprot.org/uniprot/Q00779 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation.|||Endoplasmic reticulum membrane|||Has different conformational states with differential Ca2+ affinity. The E1 conformational state (active form) shows high Ca(2+) affinity, while the E2 state exhibits low Ca(2+) affinity. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Inhibited by sarcolipin (SLN) and myoregulin (MRLN). The inhibition is blocked by VMP1 (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Stabilizes SERCA2 in its E2 state (By similarity).|||Interacts with TRAM2 (via C-terminus).|||Interacts with sarcolipin (SLN); the interaction inhibits ATP2A2 Ca(2+) affinity. Interacts with phospholamban (PLN); the interaction inhibits ATP2A2 Ca(2+) affinity (By similarity). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Interacts with HAX1 (By similarity). Interacts with S100A8 and S100A9 (By similarity). Interacts with SLC35G1 and STIM1. Interacts with TMEM203 (By similarity). Interacts with TMEM64 and PDIA3 (By similarity). Interacts with TMX2 (By similarity). Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2. Interacts with ULK1 (By similarity). Interacts with S100A1 in a Ca(2+)-dependent manner (By similarity). Interacts with TUNAR (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and promotes ATP2A2 proteasomal degradation; this complex is dissociated upon heme binding. Interacts with FNIP1.|||Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation.|||Isoform 1 is expressed in the heart.|||Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity.|||PLN and SLN both have a single transmembrane helix; both occupy a similar binding site that is situated between the ATP2A2 transmembrane helices.|||Sarcoplasmic reticulum membrane|||Serotonylated on Gln residues by TGM2 in response to hypoxia, leading to its inactivation.|||This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes (By similarity). In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). http://togogenome.org/gene/9685:CXCR3 ^@ http://purl.uniprot.org/uniprot/M3WTQ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/9685:RSL24D1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U291 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9685:SFXN4 ^@ http://purl.uniprot.org/uniprot/M3WDN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/9685:JUNB ^@ http://purl.uniprot.org/uniprot/M3WS52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/9685:ACADVL ^@ http://purl.uniprot.org/uniprot/A0A337SL36 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9685:DYNLT5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPC0 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9685:GABRA6 ^@ http://purl.uniprot.org/uniprot/A0A337SQ96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:SF3A1 ^@ http://purl.uniprot.org/uniprot/M3WG15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SLC33A1 ^@ http://purl.uniprot.org/uniprot/M3X228 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:UBLCP1 ^@ http://purl.uniprot.org/uniprot/A0A337SD56 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:KRT73 ^@ http://purl.uniprot.org/uniprot/M1RGZ2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:TAS2R1 ^@ http://purl.uniprot.org/uniprot/M3WH93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9685:RPL27A ^@ http://purl.uniprot.org/uniprot/M3W9J7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9685:SLC6A12 ^@ http://purl.uniprot.org/uniprot/M3X4J5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.|||Cell membrane|||Interacts with LIN7C.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9685:ATP11C ^@ http://purl.uniprot.org/uniprot/A0A2I2U6C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9685:NFRKB ^@ http://purl.uniprot.org/uniprot/M3W1L1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:MACIR ^@ http://purl.uniprot.org/uniprot/M3WD62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9685:SLC6A15 ^@ http://purl.uniprot.org/uniprot/M3X326 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/9685:LOC101101645 ^@ http://purl.uniprot.org/uniprot/M3X0W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:EDA ^@ http://purl.uniprot.org/uniprot/A0A337S6U3 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9685:MC2R ^@ http://purl.uniprot.org/uniprot/M3WZX2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/9685:DUSP2 ^@ http://purl.uniprot.org/uniprot/M3WDR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9685:NME9 ^@ http://purl.uniprot.org/uniprot/M3X2W4 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9685:CXCL10 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9685:CA6 ^@ http://purl.uniprot.org/uniprot/A0A337SFR4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9685:CACNA1S ^@ http://purl.uniprot.org/uniprot/A0A2I2UAM3|||http://purl.uniprot.org/uniprot/Q2QCM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/9685:TOR2A ^@ http://purl.uniprot.org/uniprot/M3WVJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9685:MGST2 ^@ http://purl.uniprot.org/uniprot/M3X1T6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:ALOX12B ^@ http://purl.uniprot.org/uniprot/M3WM43 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:TATDN1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7W8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9685:PPM1K ^@ http://purl.uniprot.org/uniprot/A0A2I2UN26 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9685:GDF10 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y1W4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9685:TRMO ^@ http://purl.uniprot.org/uniprot/M3WEA0 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/9685:SLC35F1 ^@ http://purl.uniprot.org/uniprot/M3XBA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9685:FUT11 ^@ http://purl.uniprot.org/uniprot/A0A2I2UM36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9685:TLCD2 ^@ http://purl.uniprot.org/uniprot/M3W5M9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PUS3 ^@ http://purl.uniprot.org/uniprot/M3W3W9 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9685:FYTTD1 ^@ http://purl.uniprot.org/uniprot/M3WCI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UIF family.|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9685:ART4 ^@ http://purl.uniprot.org/uniprot/M3XDK8 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9685:HNRNPDL ^@ http://purl.uniprot.org/uniprot/M3VUT2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:TAMM41 ^@ http://purl.uniprot.org/uniprot/M3X3C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:PRDM14 ^@ http://purl.uniprot.org/uniprot/M3VWM4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SNX33 ^@ http://purl.uniprot.org/uniprot/M3WGW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9685:RPS8 ^@ http://purl.uniprot.org/uniprot/M3XE20 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/9685:TRMT13 ^@ http://purl.uniprot.org/uniprot/M3X3A4 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/9685:ADORA3 ^@ http://purl.uniprot.org/uniprot/M3X1I1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9685:MAN1C1 ^@ http://purl.uniprot.org/uniprot/M3WHL7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9685:LOC101100254 ^@ http://purl.uniprot.org/uniprot/M3XFT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:RIN1 ^@ http://purl.uniprot.org/uniprot/M3WB71 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9685:RPL13A ^@ http://purl.uniprot.org/uniprot/M3WAY9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9685:LOC102901994 ^@ http://purl.uniprot.org/uniprot/A0A5F5XT71 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9685:FLAI-K ^@ http://purl.uniprot.org/uniprot/S4Z3H8 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9685:LEAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UMV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/9685:TSC22D3 ^@ http://purl.uniprot.org/uniprot/A0A337SGM8|||http://purl.uniprot.org/uniprot/A0A337SNR1 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9685:PPP6C ^@ http://purl.uniprot.org/uniprot/A0A2I2U7E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9685:FELCATV1R7 ^@ http://purl.uniprot.org/uniprot/M3X8C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A337SR29|||http://purl.uniprot.org/uniprot/M3X9M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:ACSF3 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y7K3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:PLPPR4 ^@ http://purl.uniprot.org/uniprot/A0A337SCK5|||http://purl.uniprot.org/uniprot/B3GAJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9685:ABCC2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y6K4|||http://purl.uniprot.org/uniprot/M3WKM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:GABRR1 ^@ http://purl.uniprot.org/uniprot/M3XEV9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:SEC23B ^@ http://purl.uniprot.org/uniprot/M3WJJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9685:BLOC1S6 ^@ http://purl.uniprot.org/uniprot/A0A337S6D6 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/9685:MAX ^@ http://purl.uniprot.org/uniprot/P61245 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAX family.|||Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity (By similarity).|||Nucleus|||Phosphorylated.|||Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity (By similarity). Represses MYC transcriptional activity from E-box elements (By similarity).|||dendrite http://togogenome.org/gene/9685:TK2 ^@ http://purl.uniprot.org/uniprot/A0A337SM65 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9685:SLC41A1 ^@ http://purl.uniprot.org/uniprot/M3X7L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9685:PYGB ^@ http://purl.uniprot.org/uniprot/M3W9K0 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9685:CA3H2orf68 ^@ http://purl.uniprot.org/uniprot/M3X0X7 ^@ Similarity ^@ Belongs to the UPF0561 family. http://togogenome.org/gene/9685:SLC7A1 ^@ http://purl.uniprot.org/uniprot/A0A337SSZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101092267 ^@ http://purl.uniprot.org/uniprot/M3X6T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:SLC39A8 ^@ http://purl.uniprot.org/uniprot/M3WFU4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RPS10 ^@ http://purl.uniprot.org/uniprot/M3WMF9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9685:KEF43_p05 ^@ http://purl.uniprot.org/uniprot/P48931 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:DMRTC2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y4C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9685:OTC ^@ http://purl.uniprot.org/uniprot/M3WE39 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/9685:CALHM2 ^@ http://purl.uniprot.org/uniprot/M3VYF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9685:LOC105260977 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCY9 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9685:MAGT1 ^@ http://purl.uniprot.org/uniprot/M3X2H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A2I2UE61 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9685:SEC22B ^@ http://purl.uniprot.org/uniprot/M3X0S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9685:LOC101094730 ^@ http://purl.uniprot.org/uniprot/M3X5N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9685:GABARAP ^@ http://purl.uniprot.org/uniprot/M3X7G0 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9685:LOC101082424 ^@ http://purl.uniprot.org/uniprot/A0A2I2V250 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9685:GRB10 ^@ http://purl.uniprot.org/uniprot/M3WGL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9685:GLIPR1 ^@ http://purl.uniprot.org/uniprot/M3W3N0 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9685:ETV4 ^@ http://purl.uniprot.org/uniprot/M3WCC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9685:LGI3 ^@ http://purl.uniprot.org/uniprot/M3W3T4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9685:TASOR ^@ http://purl.uniprot.org/uniprot/A0A2I2U242|||http://purl.uniprot.org/uniprot/A0A2I2UT58|||http://purl.uniprot.org/uniprot/M3VZ74 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9685:VAMP4 ^@ http://purl.uniprot.org/uniprot/M3WIR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9685:HDAC7 ^@ http://purl.uniprot.org/uniprot/A0A2I2UC12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9685:CLTCL1 ^@ http://purl.uniprot.org/uniprot/M3WZ57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/9685:RIOK3 ^@ http://purl.uniprot.org/uniprot/M3VUX4 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.|||Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. http://togogenome.org/gene/9685:BET1L ^@ http://purl.uniprot.org/uniprot/A0A2I2U3S6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A337SCD1|||http://purl.uniprot.org/uniprot/A0A337STZ9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:PPARGC1A ^@ http://purl.uniprot.org/uniprot/M3VTZ8 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9685:IK ^@ http://purl.uniprot.org/uniprot/M3VWC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/9685:LOC101093190 ^@ http://purl.uniprot.org/uniprot/M3X6Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:SV2C ^@ http://purl.uniprot.org/uniprot/M3W047 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9685:VCAM1 ^@ http://purl.uniprot.org/uniprot/M3WED4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9685:TNFSF15 ^@ http://purl.uniprot.org/uniprot/M3VU80 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9685:BRIX1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UF52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9685:TSPAN31 ^@ http://purl.uniprot.org/uniprot/M3WQH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:P3H2 ^@ http://purl.uniprot.org/uniprot/M3VVE5 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9685:RPS15A ^@ http://purl.uniprot.org/uniprot/M3WDL6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/9685:TRAF2 ^@ http://purl.uniprot.org/uniprot/M3VUN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9685:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/M3XDN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9685:RPL36AL ^@ http://purl.uniprot.org/uniprot/M3WWJ1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9685:APAF1 ^@ http://purl.uniprot.org/uniprot/A0A337S9X3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/9685:FAM234A ^@ http://purl.uniprot.org/uniprot/M3WAU7 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9685:LOC101081428 ^@ http://purl.uniprot.org/uniprot/M3WA04 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9685:RAB18 ^@ http://purl.uniprot.org/uniprot/M3WSV9 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9685:GAB1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3H6|||http://purl.uniprot.org/uniprot/A0A2I2UZ86|||http://purl.uniprot.org/uniprot/M3X119 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9685:LOC101080826 ^@ http://purl.uniprot.org/uniprot/M3WJA1 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9685:APOC4 ^@ http://purl.uniprot.org/uniprot/M3W2V3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C4 family.|||May participate in lipoprotein metabolism.|||Secreted http://togogenome.org/gene/9685:SRPX2 ^@ http://purl.uniprot.org/uniprot/M3W039 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:LOC101090164 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TARS3 ^@ http://purl.uniprot.org/uniprot/M3WAB4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:MRPL18 ^@ http://purl.uniprot.org/uniprot/M3VZ90 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/9685:VCAN ^@ http://purl.uniprot.org/uniprot/A0A337S7H7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9685:SLC16A13 ^@ http://purl.uniprot.org/uniprot/A0A5F5XPP3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RSPO4 ^@ http://purl.uniprot.org/uniprot/M3WP14 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9685:TNFSF13 ^@ http://purl.uniprot.org/uniprot/D2ITC1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9685:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/A0A337SK85 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101095929 ^@ http://purl.uniprot.org/uniprot/A0A2I2UD68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101097188 ^@ http://purl.uniprot.org/uniprot/M3WU87 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101087522 ^@ http://purl.uniprot.org/uniprot/M3X7I4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:VDR ^@ http://purl.uniprot.org/uniprot/M3X4E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:REN ^@ http://purl.uniprot.org/uniprot/M3VZC9 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9685:BAX ^@ http://purl.uniprot.org/uniprot/Q8SQ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane http://togogenome.org/gene/9685:MICOS10 ^@ http://purl.uniprot.org/uniprot/M3VZN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:TNF ^@ http://purl.uniprot.org/uniprot/P19101 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).|||Homotrimer. Interacts with SPPL2B (By similarity).|||Membrane|||O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.|||Secreted|||The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).|||The soluble form is demyristoylated by SIRT6, promoting its secretion. http://togogenome.org/gene/9685:ERBIN ^@ http://purl.uniprot.org/uniprot/A0A2I2UIE6|||http://purl.uniprot.org/uniprot/A0A337SCI1|||http://purl.uniprot.org/uniprot/A0A337SWU1 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9685:TCTN1 ^@ http://purl.uniprot.org/uniprot/M3WEL3 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9685:HSD17B4 ^@ http://purl.uniprot.org/uniprot/M3W9K8 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9685:PSMB2 ^@ http://purl.uniprot.org/uniprot/M3XCX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:TFE3 ^@ http://purl.uniprot.org/uniprot/M3VYS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9685:CCSER1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UE78|||http://purl.uniprot.org/uniprot/A0A5F5XGC6 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9685:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/M3XBC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9685:CTSK ^@ http://purl.uniprot.org/uniprot/M3W0Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9685:ZNF706 ^@ http://purl.uniprot.org/uniprot/A0A337SAK6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:LOC101086605 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9685:MUL1 ^@ http://purl.uniprot.org/uniprot/M3WWN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RPA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UEQ9 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/9685:SLC12A6 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7J3|||http://purl.uniprot.org/uniprot/A0A2I2UF14|||http://purl.uniprot.org/uniprot/M3VX68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9685:TAP1 ^@ http://purl.uniprot.org/uniprot/M3WC96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9685:EIF3E ^@ http://purl.uniprot.org/uniprot/M3W0R4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.|||Cytoplasm|||Nucleus|||PML body|||Phosphorylated upon DNA damage, probably by ATM or ATR. http://togogenome.org/gene/9685:DIAPH3 ^@ http://purl.uniprot.org/uniprot/M3WQG3 ^@ Similarity ^@ Belongs to the formin homology family. Diaphanous subfamily. http://togogenome.org/gene/9685:PYROXD1 ^@ http://purl.uniprot.org/uniprot/M3WHX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.|||sarcomere http://togogenome.org/gene/9685:CACNG3 ^@ http://purl.uniprot.org/uniprot/M3WEG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/9685:LOC105260995 ^@ http://purl.uniprot.org/uniprot/M3X6D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DCLK2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ98|||http://purl.uniprot.org/uniprot/A0A2I2UVM1|||http://purl.uniprot.org/uniprot/M3WCD0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9685:ENY2 ^@ http://purl.uniprot.org/uniprot/M3XCF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9685:LOC101097969 ^@ http://purl.uniprot.org/uniprot/M3VV19 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A337SH78 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:ATP8B4 ^@ http://purl.uniprot.org/uniprot/M3X482 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9685:RBM3 ^@ http://purl.uniprot.org/uniprot/M3VY54 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:CTSD ^@ http://purl.uniprot.org/uniprot/M3W8G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Lysosome|||extracellular space http://togogenome.org/gene/9685:GRIN2B ^@ http://purl.uniprot.org/uniprot/M3WID6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9685:DCLRE1A ^@ http://purl.uniprot.org/uniprot/M3WFU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9685:CRYAB ^@ http://purl.uniprot.org/uniprot/M3WT79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small heat shock protein (HSP20) family.|||Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.|||Cytoplasm|||Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA.|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|||Nucleus http://togogenome.org/gene/9685:CRYBA4 ^@ http://purl.uniprot.org/uniprot/M3WDS9 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9685:SLC7A14 ^@ http://purl.uniprot.org/uniprot/M3WEP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RAB32 ^@ http://purl.uniprot.org/uniprot/M3X7A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9685:AIF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2USF2 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9685:IL17RD ^@ http://purl.uniprot.org/uniprot/M3W0K4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:UBE2A ^@ http://purl.uniprot.org/uniprot/M3WS15 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9685:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A337SIK8|||http://purl.uniprot.org/uniprot/M3W1M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/9685:PUS10 ^@ http://purl.uniprot.org/uniprot/M3W8T7 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/9685:AMIGO1 ^@ http://purl.uniprot.org/uniprot/M3WMW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9685:FAM162A ^@ http://purl.uniprot.org/uniprot/M3WVD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9685:BTG2 ^@ http://purl.uniprot.org/uniprot/M3WSJ8 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9685:FGF17 ^@ http://purl.uniprot.org/uniprot/M3W464 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9685:ATP23 ^@ http://purl.uniprot.org/uniprot/M3XA84 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/9685:NR4A1 ^@ http://purl.uniprot.org/uniprot/M3VUE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR4 subfamily.|||In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.|||Nucleus|||cytosol http://togogenome.org/gene/9685:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A337S7Y4|||http://purl.uniprot.org/uniprot/A0A337SHX4|||http://purl.uniprot.org/uniprot/M3WWX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/9685:KEF43_p10 ^@ http://purl.uniprot.org/uniprot/P48890 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a dinuclear copper A center per subunit.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:SLC15A2 ^@ http://purl.uniprot.org/uniprot/M3WA33 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9685:HCAR2 ^@ http://purl.uniprot.org/uniprot/M3WNC8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:ETNPPL ^@ http://purl.uniprot.org/uniprot/A0A2I2V1A7 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9685:GDPGP1 ^@ http://purl.uniprot.org/uniprot/M3W3S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/9685:LOC101101223 ^@ http://purl.uniprot.org/uniprot/M3X9C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CXCL13 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9685:KDELR3 ^@ http://purl.uniprot.org/uniprot/M3VZ68 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:CCL24 ^@ http://purl.uniprot.org/uniprot/M3WYH2 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9685:ARRDC1 ^@ http://purl.uniprot.org/uniprot/M3XEH2 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9685:SARS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UDH0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/9685:CAST ^@ http://purl.uniprot.org/uniprot/M3W373 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/9685:LOC101084129 ^@ http://purl.uniprot.org/uniprot/M3WE33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:EGR2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XQV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9685:HNRNPH1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UXE4|||http://purl.uniprot.org/uniprot/A0A337SDC1|||http://purl.uniprot.org/uniprot/A0A337SQ04 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9685:RPS17 ^@ http://purl.uniprot.org/uniprot/P63275 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS17 family.|||Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||Cytoplasm|||Ubiquitinated at Lys-103 by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling).|||nucleolus http://togogenome.org/gene/9685:LOC101097782 ^@ http://purl.uniprot.org/uniprot/A0A5F5XEY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9685:RAD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/9685:ZDHHC8 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4T9|||http://purl.uniprot.org/uniprot/M3W1Q0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:TRIM32 ^@ http://purl.uniprot.org/uniprot/K7ZMH7 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9685:EHD4 ^@ http://purl.uniprot.org/uniprot/M3WXE7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9685:TLX3 ^@ http://purl.uniprot.org/uniprot/A0A2I2V1A4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PLD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYK1 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9685:SNX5 ^@ http://purl.uniprot.org/uniprot/M3W4Q8 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9685:PSENEN ^@ http://purl.uniprot.org/uniprot/M3WRU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9685:HSD17B11 ^@ http://purl.uniprot.org/uniprot/M3X4D0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:SLC25A2 ^@ http://purl.uniprot.org/uniprot/A0A337SBD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9685:SELENBP1 ^@ http://purl.uniprot.org/uniprot/M3VXE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Interacts with USP33.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/9685:DNPEP ^@ http://purl.uniprot.org/uniprot/A0A337S8S9 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/9685:RNF121 ^@ http://purl.uniprot.org/uniprot/M3W3V2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:AGAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3J0|||http://purl.uniprot.org/uniprot/A0A2I2UDH6|||http://purl.uniprot.org/uniprot/M3WL60 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/9685:RPLP0 ^@ http://purl.uniprot.org/uniprot/M3WIQ1 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9685:HDAC6 ^@ http://purl.uniprot.org/uniprot/A0A337SDX9 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 2 subfamily. http://togogenome.org/gene/9685:P2RY2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/M3W5H1 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/9685:LOC101083714 ^@ http://purl.uniprot.org/uniprot/M3VWT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9685:ARRDC3 ^@ http://purl.uniprot.org/uniprot/M3WPP8 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9685:TAT ^@ http://purl.uniprot.org/uniprot/M3W228 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9685:LOC101090380 ^@ http://purl.uniprot.org/uniprot/M3XAC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:KYNU ^@ http://purl.uniprot.org/uniprot/A0A5F5XMX8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CDH24 ^@ http://purl.uniprot.org/uniprot/A0A337SEZ0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101100475 ^@ http://purl.uniprot.org/uniprot/M3WUJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:AKR1B1 ^@ http://purl.uniprot.org/uniprot/M3WHU0 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9685:LOC101083933 ^@ http://purl.uniprot.org/uniprot/M3WSM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:PLA2G2F ^@ http://purl.uniprot.org/uniprot/A0A2I2UWG3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9685:RRS1 ^@ http://purl.uniprot.org/uniprot/M3WKI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/9685:DPF3 ^@ http://purl.uniprot.org/uniprot/M3WL59 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9685:NDOR1 ^@ http://purl.uniprot.org/uniprot/M3WSR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.|||perinuclear region http://togogenome.org/gene/9685:LDHB ^@ http://purl.uniprot.org/uniprot/A0A2I2U9C6 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9685:MDM4 ^@ http://purl.uniprot.org/uniprot/M3WLG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/9685:CAP1 ^@ http://purl.uniprot.org/uniprot/M3WH00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SLC4A11 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3A8|||http://purl.uniprot.org/uniprot/A0A5F5XL25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:GMPR ^@ http://purl.uniprot.org/uniprot/M3WDD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9685:TYRP1 ^@ http://purl.uniprot.org/uniprot/Q2VPW6 ^@ Activity Regulation|||Cofactor|||Function|||Miscellaneous|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allelic variations in TYRP1 may be associated with brown (allele chocolate) or cinnamon (allele cinnamon) coat color in domestic cats.|||Belongs to the tyrosinase family.|||Contains bound zinc ions after heterologous expression in insect cells, giving rise to a protein that lacks DHICA oxidase activity.|||May be due to competing donor splice site.|||Melanosome membrane|||Monomer (By similarity). Interacts with ATP7A (By similarity). Interacts with SLC45A2 (By similarity).|||Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized (By similarity). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).|||The activity depends critically on the nature of the bound metal ion. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) in the presence of bound Cu(2+) ions, but lacks activity in the presence of bound Zn(2+) ions. http://togogenome.org/gene/9685:LPAR1 ^@ http://purl.uniprot.org/uniprot/M3WVC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/9685:FGF9 ^@ http://purl.uniprot.org/uniprot/M3X6Y4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9685:LOC101085800 ^@ http://purl.uniprot.org/uniprot/M3X0Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101100413 ^@ http://purl.uniprot.org/uniprot/A0A2I2UWX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:C5AR1 ^@ http://purl.uniprot.org/uniprot/A0A337S525 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9685:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A2I2UUN8|||http://purl.uniprot.org/uniprot/A0A2I2V373|||http://purl.uniprot.org/uniprot/F1CNG6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:LOC101090391 ^@ http://purl.uniprot.org/uniprot/M3X3G5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GSKIP ^@ http://purl.uniprot.org/uniprot/A0A2I2UQ57 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/9685:GPR137C ^@ http://purl.uniprot.org/uniprot/M3WDB0 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9685:SMN2 ^@ http://purl.uniprot.org/uniprot/Q8HYB8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMN family.|||Cajal body|||Cytoplasm|||Cytoplasmic granule|||Homooligomer; may form higher order homooligomers in the dimer to octamer range. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Component of an import snRNP complex composed of KPNB1, RNUT1, SMN1 and ZNF259. Interacts with DDX20, FBL, NOLA1, RNUT1, SYNCRIP and with several spliceosomal snRNP core Sm proteins, including SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE and ILF3. Interacts with GEMIN2; the interaction is direct. Interacts with GEMIN3; the interaction is direct. Interacts with GEMIN8; the interaction is direct. Interacts with SNRPB; the interaction is direct. Interacts (via Tudor domain) with SNRPD1 (via C-terminus); the interaction is direct. Interacts with SNRPD2; the interaction is direct. Interacts (via Tudor domain) with SNRPD3 (via C-terminus); the interaction is direct. Interacts with SNRPE; the interaction is direct. Interacts with OSTF1, LSM10, LSM11 and RPP20/POP7. Interacts (via C-terminal region) with ZPR1 (via C-terminal region). Interacts (via Tudor domain) with COIL. Interacts with SETX; recruits SETX to POLR2A. Interacts with POLR2A (via the C-terminal domain (CTD)). Interacts with PRMT5. Interacts with XRN2. Interacts (via C-terminus) with FMR1 (via C-terminus); the interaction is direct and occurs in a RNA-independent manner. Interacts (via Tudor domain) with SF3B2 ('Arg-508'-methylated form). Interacts with WRAP53/TCAB1. Interacts (via Tudor domain) with ELAVL4 in an RNA-independent manner; the interaction is required for localization of ELAVL4 to RNA granules. Interacts with FRG1.|||Perikaryon|||The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).|||The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.|||Z line|||axon|||gem|||neuron projection http://togogenome.org/gene/9685:CCN5 ^@ http://purl.uniprot.org/uniprot/M3VYK2 ^@ Similarity ^@ Belongs to the CCN family. http://togogenome.org/gene/9685:TAS2R9 ^@ http://purl.uniprot.org/uniprot/M3W1M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9685:PDE1A ^@ http://purl.uniprot.org/uniprot/M3W3R7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:LOC101082530 ^@ http://purl.uniprot.org/uniprot/M3X5N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:DXO ^@ http://purl.uniprot.org/uniprot/M3W2C1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/9685:GORASP2 ^@ http://purl.uniprot.org/uniprot/M3WQ88 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9685:IDO1 ^@ http://purl.uniprot.org/uniprot/M3W0P8 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9685:SSH3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XF23 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/9685:FAM227B ^@ http://purl.uniprot.org/uniprot/A0A5F5XFL0 ^@ Similarity ^@ Belongs to the FAM227 family. http://togogenome.org/gene/9685:MED20 ^@ http://purl.uniprot.org/uniprot/M3XB75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9685:CDC26 ^@ http://purl.uniprot.org/uniprot/M3W472 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9685:SLC39A1 ^@ http://purl.uniprot.org/uniprot/M3WWQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQR5|||http://purl.uniprot.org/uniprot/A0A2I2V1Y0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9685:GBP5 ^@ http://purl.uniprot.org/uniprot/M3VVU6 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9685:PTGFR ^@ http://purl.uniprot.org/uniprot/I6L9K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:CAT ^@ http://purl.uniprot.org/uniprot/M3VXR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/9685:LTV1 ^@ http://purl.uniprot.org/uniprot/M3W9U2 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9685:NDUFA7 ^@ http://purl.uniprot.org/uniprot/M3WM64 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA7 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/9685:MVB12A ^@ http://purl.uniprot.org/uniprot/A0A337SL83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9685:CDH6 ^@ http://purl.uniprot.org/uniprot/M3VUL6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:SCAND1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4S2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SLC17A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCB9|||http://purl.uniprot.org/uniprot/A0A2I2UU43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TMEM53 ^@ http://purl.uniprot.org/uniprot/M3W7G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/9685:HP ^@ http://purl.uniprot.org/uniprot/E3UTY9 ^@ Caution|||Function|||Similarity ^@ As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.|||Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:CA3 ^@ http://purl.uniprot.org/uniprot/M3WS40 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9685:VPS45 ^@ http://purl.uniprot.org/uniprot/M3WCQ2 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9685:EMG1 ^@ http://purl.uniprot.org/uniprot/M3W1X7 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9685:DDO ^@ http://purl.uniprot.org/uniprot/M3VX19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9685:SPOUT1 ^@ http://purl.uniprot.org/uniprot/M3XBQ2 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/9685:ETF1 ^@ http://purl.uniprot.org/uniprot/M3WU44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/9685:OSTC ^@ http://purl.uniprot.org/uniprot/A0A2I2UAV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/9685:DEFB123 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9685:DPM3 ^@ http://purl.uniprot.org/uniprot/M3WRQ4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/9685:SERPINA9 ^@ http://purl.uniprot.org/uniprot/M3WCX3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9685:CCL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UC63 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9685:ATXN1L ^@ http://purl.uniprot.org/uniprot/A0A2I2UDK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9685:TMED10 ^@ http://purl.uniprot.org/uniprot/M3VWQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:GHRL ^@ http://purl.uniprot.org/uniprot/Q6BEG6 ^@ Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation ^@ 2.5-fold increase in plasma level of ghrelin upon fasting.|||Amidation of Leu-98 is essential for obestatin activity.|||Belongs to the motilin family.|||Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity).|||O-octanoylated by GOAT/MBOAT4 (By similarity). O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-27-C10:1, ghrelin-27-C10:2, ghrelin-28-C8:1, ghrelin-28-C10:1, and ghrelin-28-C10:2, may be modified with singly or doubly unsaturated carboxylic acids (PubMed:16466902).|||Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).|||Secreted http://togogenome.org/gene/9685:CTSW ^@ http://purl.uniprot.org/uniprot/A0A2I2U1T6|||http://purl.uniprot.org/uniprot/A0A5F5XF82|||http://purl.uniprot.org/uniprot/Q9TST1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Endoplasmic reticulum|||May have a specific function in the mechanism or regulation of T-cell cytolytic activity. http://togogenome.org/gene/9685:PIK3C2G ^@ http://purl.uniprot.org/uniprot/A0A2I2UQE0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9685:MLH3 ^@ http://purl.uniprot.org/uniprot/M3X1R3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9685:EXOC8 ^@ http://purl.uniprot.org/uniprot/M3X5S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/9685:TEAD2 ^@ http://purl.uniprot.org/uniprot/M3VWT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:FABP4 ^@ http://purl.uniprot.org/uniprot/M3WSU7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9685:IMMP2L ^@ http://purl.uniprot.org/uniprot/A0A337SD39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:AP5M1 ^@ http://purl.uniprot.org/uniprot/A0A337S9S7 ^@ Subcellular Location Annotation|||Subunit ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. http://togogenome.org/gene/9685:TIMM9 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULI5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9685:NPPA ^@ http://purl.uniprot.org/uniprot/Q9GLD0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Cleavage by MME initiates degradation of the factor and thereby regulates its activity. Degradation by IDE results in reduced activation of NPR1 (in vitro). During IDE degradation, the resulting products can temporarily stimulate NPR2 to produce cGMP, before the fragments are completely degraded and inactivated by IDE (in vitro).|||Degraded by IDE.|||Homodimer; disulfide-linked antiparallel dimer.|||Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.|||Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (By similarity). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity).|||May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.|||May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity).|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Perikaryon|||Phosphorylation on Ser-129 decreases vasorelaxant activity.|||Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, a heterologous and in vivo expression study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).|||Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, an in vivo study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).|||Secreted|||The precursor molecule is proteolytically cleaved by CORIN at Arg-123 to produce the atrial natriuretic peptide (By similarity). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (By similarity). Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin (By similarity). http://togogenome.org/gene/9685:PPFIA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U896|||http://purl.uniprot.org/uniprot/A0A2I2UGL8 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9685:LYG2 ^@ http://purl.uniprot.org/uniprot/M3W055 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9685:POLR2D ^@ http://purl.uniprot.org/uniprot/M3WUR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9685:IFGGE ^@ http://purl.uniprot.org/uniprot/J7PDP3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/9685:EML6 ^@ http://purl.uniprot.org/uniprot/M3WNG1 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/9685:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/M3XAK7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:TSPAN7 ^@ http://purl.uniprot.org/uniprot/M3WE14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:FUT10 ^@ http://purl.uniprot.org/uniprot/M3W131 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9685:LOC101094593 ^@ http://purl.uniprot.org/uniprot/M3WLP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9685:YTHDF3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAI3 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9685:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A2I2U8E7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:CHAT ^@ http://purl.uniprot.org/uniprot/A0A2I2U4U6 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9685:TK1 ^@ http://purl.uniprot.org/uniprot/M3WI14 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/9685:PROX1 ^@ http://purl.uniprot.org/uniprot/M3WRD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:AP2A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4V1|||http://purl.uniprot.org/uniprot/M3W262 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).|||Belongs to the adaptor complexes large subunit family.|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.|||coated pit http://togogenome.org/gene/9685:CADM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUH5|||http://purl.uniprot.org/uniprot/A0A337S526 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9685:TYROBP ^@ http://purl.uniprot.org/uniprot/M3W675 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TYROBP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:ABCD4 ^@ http://purl.uniprot.org/uniprot/M3W5H5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:DLAT ^@ http://purl.uniprot.org/uniprot/M3WN19 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Mitochondrion matrix|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/9685:PSMC5 ^@ http://purl.uniprot.org/uniprot/M3W0G3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9685:PDE6B ^@ http://purl.uniprot.org/uniprot/M3W967 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9685:SSR4 ^@ http://purl.uniprot.org/uniprot/M3W1G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9685:NDC1 ^@ http://purl.uniprot.org/uniprot/M3XCP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDC1 family.|||Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.|||Membrane|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9685:ACOX3 ^@ http://purl.uniprot.org/uniprot/M3WMB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/9685:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/M3VYI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule|||filopodium|||growth cone|||lamellipodium|||perinuclear region http://togogenome.org/gene/9685:MMP7 ^@ http://purl.uniprot.org/uniprot/A0A0A0MQ21 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:BPGM ^@ http://purl.uniprot.org/uniprot/M3WX85 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9685:PPIL4 ^@ http://purl.uniprot.org/uniprot/M3WEU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9685:EIF5A2 ^@ http://purl.uniprot.org/uniprot/M3W8Z1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/9685:LOC101096930 ^@ http://purl.uniprot.org/uniprot/M3WXJ7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CHAF1B ^@ http://purl.uniprot.org/uniprot/M3VZF6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SEMA3F ^@ http://purl.uniprot.org/uniprot/A0A2I2U3B1|||http://purl.uniprot.org/uniprot/M3W6X0 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:ADAM8 ^@ http://purl.uniprot.org/uniprot/A0A2I2V2H3|||http://purl.uniprot.org/uniprot/M3WPQ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:F2 ^@ http://purl.uniprot.org/uniprot/M3WSI8 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/9685:RUVBL1 ^@ http://purl.uniprot.org/uniprot/M3WAA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/9685:FXYD5 ^@ http://purl.uniprot.org/uniprot/A0A337S0G5 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9685:ALDH3A2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQB7|||http://purl.uniprot.org/uniprot/M3WTG1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9685:TERF1 ^@ http://purl.uniprot.org/uniprot/M3XBD0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9685:LOC101086751 ^@ http://purl.uniprot.org/uniprot/M3X205 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:RGN ^@ http://purl.uniprot.org/uniprot/A0A337SL03 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9685:SLC37A4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U150|||http://purl.uniprot.org/uniprot/A0A5F5XYT0|||http://purl.uniprot.org/uniprot/M3VW29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9685:SPSB2 ^@ http://purl.uniprot.org/uniprot/M3WYE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/9685:FUS ^@ http://purl.uniprot.org/uniprot/M3X5Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9685:CNOT7 ^@ http://purl.uniprot.org/uniprot/A0A337SI41|||http://purl.uniprot.org/uniprot/M3VV22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9685:MASTL ^@ http://purl.uniprot.org/uniprot/M3WKC3 ^@ Subcellular Location Annotation ^@ Nucleus|||centrosome http://togogenome.org/gene/9685:SUPT6H ^@ http://purl.uniprot.org/uniprot/M3W1E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/9685:CYP1A2 ^@ http://purl.uniprot.org/uniprot/A0A0A0MPX5|||http://purl.uniprot.org/uniprot/Q5KQT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation.|||Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.|||Membrane|||Microsome membrane http://togogenome.org/gene/9685:HPS5 ^@ http://purl.uniprot.org/uniprot/M3WEL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPS5 family.|||Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||cytosol http://togogenome.org/gene/9685:NR1H4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1J3|||http://purl.uniprot.org/uniprot/M3W5Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9685:ANP32A ^@ http://purl.uniprot.org/uniprot/A0A2I2UW24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9685:CA3H2orf49 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9685:DZIP3 ^@ http://purl.uniprot.org/uniprot/A0A5F5XKN4|||http://purl.uniprot.org/uniprot/A0A5F5XLB4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:STARD6 ^@ http://purl.uniprot.org/uniprot/M3X4R8 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9685:PAIP2B ^@ http://purl.uniprot.org/uniprot/A0A2I2V2S0 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/9685:TBPL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UT39 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/9685:TSPAN15 ^@ http://purl.uniprot.org/uniprot/M3W349 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:HEXIM1 ^@ http://purl.uniprot.org/uniprot/M3W448 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9685:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/M3VXG1 ^@ Caution|||Function|||Subunit ^@ Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:API5 ^@ http://purl.uniprot.org/uniprot/M3WVZ5 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/9685:TMEM168 ^@ http://purl.uniprot.org/uniprot/M3XE79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9685:AVIL ^@ http://purl.uniprot.org/uniprot/M3WL69 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9685:IFNW8 ^@ http://purl.uniprot.org/uniprot/Q0GYV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9685:DPP4 ^@ http://purl.uniprot.org/uniprot/Q9N2I7 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the peptidase S9B family. DPPIV subfamily.|||Cell junction|||Cell membrane|||Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.|||Inhibited by GPC3 and diprotin A.|||Membrane raft|||Monomer. Homodimer. Heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3.|||N- and O-Glycosylated.|||Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation (By similarity).|||Secreted|||The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9685:ZFPL1 ^@ http://purl.uniprot.org/uniprot/M3W5J7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZFPL1 family.|||Interacts with GOLGA2/GM130.|||Membrane|||Required for cis-Golgi integrity and efficient ER to Golgi transport.|||The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.|||cis-Golgi network membrane http://togogenome.org/gene/9685:LOC101093286 ^@ http://purl.uniprot.org/uniprot/A0A337S8Q9 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9685:TRAF4 ^@ http://purl.uniprot.org/uniprot/M3W1F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9685:PPP1R15B ^@ http://purl.uniprot.org/uniprot/M3WUP7 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/9685:E2F7 ^@ http://purl.uniprot.org/uniprot/M3WDV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9685:GJA5 ^@ http://purl.uniprot.org/uniprot/M3VUK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9685:SMC3 ^@ http://purl.uniprot.org/uniprot/M3WDH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/9685:RPA1 ^@ http://purl.uniprot.org/uniprot/M3W5N4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/9685:IL17A ^@ http://purl.uniprot.org/uniprot/A0A2I2ULE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9685:PGAP3 ^@ http://purl.uniprot.org/uniprot/M3WCC1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:CARNMT1 ^@ http://purl.uniprot.org/uniprot/M3WWU8 ^@ Similarity ^@ Belongs to the carnosine N-methyltransferase family. http://togogenome.org/gene/9685:WNT3 ^@ http://purl.uniprot.org/uniprot/M3WFT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9685:LOC101098257 ^@ http://purl.uniprot.org/uniprot/A0A2I2UX44 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9685:PLCG2 ^@ http://purl.uniprot.org/uniprot/M3W393 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9685:MEOX2 ^@ http://purl.uniprot.org/uniprot/M3WPT8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:CLEC12B ^@ http://purl.uniprot.org/uniprot/M3WD61 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:VARS1 ^@ http://purl.uniprot.org/uniprot/A0A337S2U8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:P4HA1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3Y8|||http://purl.uniprot.org/uniprot/A0A2I2UQ94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9685:ZNF503 ^@ http://purl.uniprot.org/uniprot/M3WCK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/9685:IL7R ^@ http://purl.uniprot.org/uniprot/M3WAZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. http://togogenome.org/gene/9685:HNRNPA1 ^@ http://purl.uniprot.org/uniprot/A0A337S498|||http://purl.uniprot.org/uniprot/M3X7W8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:GCNT2 ^@ http://purl.uniprot.org/uniprot/M3X1R7 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:PLRG1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XJ22|||http://purl.uniprot.org/uniprot/M3WPW2 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9685:LYPD2 ^@ http://purl.uniprot.org/uniprot/M3VU52 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:CALCR ^@ http://purl.uniprot.org/uniprot/M3W7Q9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Interacts with GPRASP2.|||Membrane http://togogenome.org/gene/9685:LNPEP ^@ http://purl.uniprot.org/uniprot/A0A2I2UWE2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Membrane http://togogenome.org/gene/9685:AHCYL1 ^@ http://purl.uniprot.org/uniprot/M3W3K3 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9685:SLC15A5 ^@ http://purl.uniprot.org/uniprot/M3X3J5 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/9685:TMED1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9685:SGK2 ^@ http://purl.uniprot.org/uniprot/M3VXG0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:PTGDS ^@ http://purl.uniprot.org/uniprot/Q29487 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.|||Golgi apparatus|||Monomer.|||N- and O-glycosylated. Both N-glycosylation recognition sites are almost quantitatively occupied by N-glycans of the biantennary complex type, with a considerable proportion of structures bearing a bisecting GlcNAc. N-glycan at Asn-78: dHex1Hex5HexNAc4. Agalacto structure as well as sialylated and nonsialylated oligosaccharides bearing alpha2-3- and/or alpha2-6-linked NeuNAc are present.|||Nucleus membrane|||Rough endoplasmic reticulum|||Secreted|||perinuclear region http://togogenome.org/gene/9685:GNGT1 ^@ http://purl.uniprot.org/uniprot/M3WUX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9685:RPS27L ^@ http://purl.uniprot.org/uniprot/A0A2I2UEY8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9685:IL26 ^@ http://purl.uniprot.org/uniprot/M3WDI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9685:RPS26 ^@ http://purl.uniprot.org/uniprot/M3WJU8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/9685:PSMD3 ^@ http://purl.uniprot.org/uniprot/M3WLR0 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/9685:GANC ^@ http://purl.uniprot.org/uniprot/M3VZC6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9685:PFDN1 ^@ http://purl.uniprot.org/uniprot/M3VWC0 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/9685:TSPAN18 ^@ http://purl.uniprot.org/uniprot/M3W1Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:ALG3 ^@ http://purl.uniprot.org/uniprot/M3WNC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Belongs to the glycosyltransferase 58 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:STK32B ^@ http://purl.uniprot.org/uniprot/A0A2I2UMV7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:CD2 ^@ http://purl.uniprot.org/uniprot/Q8WNV8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:DAG1 ^@ http://purl.uniprot.org/uniprot/B4XEM8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9685:FGF14 ^@ http://purl.uniprot.org/uniprot/M3WSV6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9685:SCML1 ^@ http://purl.uniprot.org/uniprot/A0A337RZD7|||http://purl.uniprot.org/uniprot/A0A337S6J8 ^@ Similarity ^@ Belongs to the SCM family. http://togogenome.org/gene/9685:CDK4 ^@ http://purl.uniprot.org/uniprot/M3WUQ1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:MOS ^@ http://purl.uniprot.org/uniprot/M3W0R3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:RNASE11 ^@ http://purl.uniprot.org/uniprot/M3X7R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9685:IL17B ^@ http://purl.uniprot.org/uniprot/M3W0P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9685:LOC101081980 ^@ http://purl.uniprot.org/uniprot/M3WXH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:ERCC4 ^@ http://purl.uniprot.org/uniprot/M3W1H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/9685:GPR156 ^@ http://purl.uniprot.org/uniprot/M3WCZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:DYNC1LI2 ^@ http://purl.uniprot.org/uniprot/M3WVF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/9685:NOP56 ^@ http://purl.uniprot.org/uniprot/M3WKR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/9685:VPS41 ^@ http://purl.uniprot.org/uniprot/A0A2I2UFR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9685:POLR2H ^@ http://purl.uniprot.org/uniprot/M3W8E3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9685:SAA1 ^@ http://purl.uniprot.org/uniprot/Q1T772 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9685:FGD6 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1M7|||http://purl.uniprot.org/uniprot/A0A5F5Y6C8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U7R0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9685:CFAP91 ^@ http://purl.uniprot.org/uniprot/M3W593 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/9685:PLXNA2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUB4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:HAT1 ^@ http://purl.uniprot.org/uniprot/M3VYK3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/9685:ABCB8 ^@ http://purl.uniprot.org/uniprot/A0A337SQ28|||http://purl.uniprot.org/uniprot/M3WIE3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TRARG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2URY2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9685:ACSM5 ^@ http://purl.uniprot.org/uniprot/M3W231 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9685:SMIM12 ^@ http://purl.uniprot.org/uniprot/M3XDT1 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/9685:PPP1R12A ^@ http://purl.uniprot.org/uniprot/A0A2I2UGC7|||http://purl.uniprot.org/uniprot/M3WZI4 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9685:LOC101086721 ^@ http://purl.uniprot.org/uniprot/M3WY36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:ENOPH1 ^@ http://purl.uniprot.org/uniprot/A0A337SNV0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9685:MGAT5B ^@ http://purl.uniprot.org/uniprot/M3W1T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A2I2UEL6|||http://purl.uniprot.org/uniprot/A0A2I2UIA4|||http://purl.uniprot.org/uniprot/M3WFD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:SND1 ^@ http://purl.uniprot.org/uniprot/M3W9B3 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/9685:FMO1 ^@ http://purl.uniprot.org/uniprot/M3W9L4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:EXO5 ^@ http://purl.uniprot.org/uniprot/M3W4K7 ^@ Similarity ^@ Belongs to the EXO5 family. http://togogenome.org/gene/9685:KIT ^@ http://purl.uniprot.org/uniprot/D7PDD5|||http://purl.uniprot.org/uniprot/Q28889 ^@ Activity Regulation|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane|||Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3CD. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1. Interacts with DOK1 and TEC. Interacts with IL1RAP (independent of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).|||Numerous proteins are phosphorylated in response to KIT signaling, but it is not evident to determine which are directly phosphorylated by KIT under in vivo conditions.|||Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Activity is down-regulated by PRKCA-mediated phosphorylation on serine residues (By similarity).|||Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity).|||Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation. http://togogenome.org/gene/9685:EFEMP1 ^@ http://purl.uniprot.org/uniprot/M3VVE6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:SIRT5 ^@ http://purl.uniprot.org/uniprot/M3XGD7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.|||Mitochondrion|||Monomer. Homodimer. Interacts with CPS1.|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.|||Nucleus|||cytosol http://togogenome.org/gene/9685:TBX20 ^@ http://purl.uniprot.org/uniprot/A0A337SBT6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9685:NLN ^@ http://purl.uniprot.org/uniprot/A0A2I2UQH0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9685:GABRE ^@ http://purl.uniprot.org/uniprot/M3W4A9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9685:SULT1C2 ^@ http://purl.uniprot.org/uniprot/A0A337SWQ2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9685:ILDR1 ^@ http://purl.uniprot.org/uniprot/M3WA36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9685:LOC101089343 ^@ http://purl.uniprot.org/uniprot/M3WW42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9685:CHMP4B ^@ http://purl.uniprot.org/uniprot/M3WXJ4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9685:DEFB127 ^@ http://purl.uniprot.org/uniprot/A0A2I2UI37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9685:MKNK1 ^@ http://purl.uniprot.org/uniprot/A0A337SSQ7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:DCP2 ^@ http://purl.uniprot.org/uniprot/M3VXH4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/9685:CAPN5 ^@ http://purl.uniprot.org/uniprot/A0A337SKD2 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9685:LOC101089717 ^@ http://purl.uniprot.org/uniprot/M3W698 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:EIF4A2 ^@ http://purl.uniprot.org/uniprot/M3WJN3 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9685:DPH3 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1V0|||http://purl.uniprot.org/uniprot/A0A2I2U4J3 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/9685:TMEM147 ^@ http://purl.uniprot.org/uniprot/M3W5T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9685:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/B5BNW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9685:PDCL2 ^@ http://purl.uniprot.org/uniprot/M3WUT1 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9685:LOC101091822 ^@ http://purl.uniprot.org/uniprot/M3WL47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9685:ZNF280D ^@ http://purl.uniprot.org/uniprot/M3XDA6 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9685:ITGA7 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4E5|||http://purl.uniprot.org/uniprot/M3WJT5|||http://purl.uniprot.org/uniprot/M3X2Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9685:HARS2 ^@ http://purl.uniprot.org/uniprot/M3VWD4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:LIG3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UG83|||http://purl.uniprot.org/uniprot/A0A5F5XPL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9685:ECRG4 ^@ http://purl.uniprot.org/uniprot/M3XBP1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/9685:PLA2G12A ^@ http://purl.uniprot.org/uniprot/A0A5F5XI58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C14A family.|||Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9685:NUP35 ^@ http://purl.uniprot.org/uniprot/A0A2I2UGB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9685:B4GALT2 ^@ http://purl.uniprot.org/uniprot/A0A337SM79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9685:KIF5A ^@ http://purl.uniprot.org/uniprot/A0A2I2ULS6|||http://purl.uniprot.org/uniprot/A0A337SAI2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:COL4A3 ^@ http://purl.uniprot.org/uniprot/A0A337RYM9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9685:TRPM3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UMZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:UMPS ^@ http://purl.uniprot.org/uniprot/M3W6I6 ^@ Similarity ^@ In the C-terminal section; belongs to the OMP decarboxylase family.|||In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9685:HSF4 ^@ http://purl.uniprot.org/uniprot/M3WK27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9685:HAPLN1 ^@ http://purl.uniprot.org/uniprot/A0A337SSS2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9685:PADI2 ^@ http://purl.uniprot.org/uniprot/M3WCU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9685:INHBE ^@ http://purl.uniprot.org/uniprot/M3VZY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9685:ROPN1 ^@ http://purl.uniprot.org/uniprot/M3W1M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ropporin family.|||flagellum http://togogenome.org/gene/9685:MLH1 ^@ http://purl.uniprot.org/uniprot/M3VWJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/9685:CAND1 ^@ http://purl.uniprot.org/uniprot/M3X6G0 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9685:SLC34A1 ^@ http://purl.uniprot.org/uniprot/M3VWU4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:CDC42EP2 ^@ http://purl.uniprot.org/uniprot/M3VWM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system|||Probably involved in the organization of the actin cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9685:ATP6V1D ^@ http://purl.uniprot.org/uniprot/A0A5F5XKK6|||http://purl.uniprot.org/uniprot/M3WEF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9685:PCK1 ^@ http://purl.uniprot.org/uniprot/M3VUQ7 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9685:KRT71 ^@ http://purl.uniprot.org/uniprot/E1AB55 ^@ Function|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A complex variation, consisting of an 81-bp deletion, including the last 4 bp of intron 6 and the first 77 bp of exon 7, followed by 2 insertions was identified. This variation was called Rex polymorphism or 'Re'. All sequenced Devon Rex cats, a breed characterized by curly hair phenotype, were homozygous for this variation and loss of homozygosity was associated with normal hair production (PubMed:20953787). A variation affecting the 5'-splice site at the junction of exon 4 and intron 4 was identified in 2 breeds, Sphynx and Kohana, that are characterized by a hairless phenotype. This variation occurred in the heterozygous or homozygous state in these breeds. It has been called hairless or hr allele and has been suggested of a cause of the hairless phenotype (PubMed:20953787).|||Belongs to the intermediate filament family.|||Heterodimer of a type I and a type II keratin. Associates with KRT16 and/or KRT17 (By similarity).|||Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.|||cytoskeleton http://togogenome.org/gene/9685:ZSCAN9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHS9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:LOC101086180 ^@ http://purl.uniprot.org/uniprot/A0A337SX33 ^@ Subcellular Location Annotation ^@ Cell junction|||Golgi stack http://togogenome.org/gene/9685:SHCBP1 ^@ http://purl.uniprot.org/uniprot/M3WFS8 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9685:ABCB11 ^@ http://purl.uniprot.org/uniprot/V5RGD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ADGRB2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:ASB17 ^@ http://purl.uniprot.org/uniprot/M3VVX1 ^@ Function ^@ May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9685:WDR48 ^@ http://purl.uniprot.org/uniprot/M3X587 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/9685:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/Q95ND3 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:TINAG ^@ http://purl.uniprot.org/uniprot/M3WAV9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9685:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A5F5XDC9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9685:IFITM5 ^@ http://purl.uniprot.org/uniprot/M3WXK5 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9685:ZIC4 ^@ http://purl.uniprot.org/uniprot/A0A2I2U6W1 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9685:DDR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TIGD6 ^@ http://purl.uniprot.org/uniprot/M3WQ55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ASPHD1 ^@ http://purl.uniprot.org/uniprot/M3WK67 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/9685:SPAG7 ^@ http://purl.uniprot.org/uniprot/A0A337SC91 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:KEF43_p08 ^@ http://purl.uniprot.org/uniprot/P48894 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:DHRS7C ^@ http://purl.uniprot.org/uniprot/M3VXD6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9685:UBA7 ^@ http://purl.uniprot.org/uniprot/G3XKQ8 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9685:NDRG1 ^@ http://purl.uniprot.org/uniprot/M3VZX9 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9685:CPA3 ^@ http://purl.uniprot.org/uniprot/M3WTD9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9685:SNRPD1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U9H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP core protein family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the minor spliceosome, which splices U12-type introns. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct. Interacts with GEMIN2; the interaction is direct. Interacts with SNRPD2; the interaction is direct.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.|||cytosol http://togogenome.org/gene/9685:CCDC22 ^@ http://purl.uniprot.org/uniprot/M3WTR7 ^@ Similarity ^@ Belongs to the CCDC22 family. http://togogenome.org/gene/9685:CBLIF ^@ http://purl.uniprot.org/uniprot/M3W7W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9685:CTNNBIP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBK0 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9685:WDR55 ^@ http://purl.uniprot.org/uniprot/M3WSI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.|||nucleolus http://togogenome.org/gene/9685:GPR87 ^@ http://purl.uniprot.org/uniprot/M3WD71 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:SNURF ^@ http://purl.uniprot.org/uniprot/M3XBI7 ^@ Similarity ^@ Belongs to the SNURF family. http://togogenome.org/gene/9685:NR3C1 ^@ http://purl.uniprot.org/uniprot/A0A0A1GK17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/9685:HIKESHI ^@ http://purl.uniprot.org/uniprot/A0A5F5XMB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9685:CPLX2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9685:RPS23 ^@ http://purl.uniprot.org/uniprot/M3WAB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9685:ASRGL1 ^@ http://purl.uniprot.org/uniprot/M3WAC3 ^@ Similarity|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer. http://togogenome.org/gene/9685:IFNGR1 ^@ http://purl.uniprot.org/uniprot/M3XA82 ^@ Similarity ^@ Belongs to the type II cytokine receptor family. http://togogenome.org/gene/9685:USP39 ^@ http://purl.uniprot.org/uniprot/A0A337S3L1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBL2|||http://purl.uniprot.org/uniprot/A0A337S2K9|||http://purl.uniprot.org/uniprot/M3X836 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIN1 family.|||Cytoplasmic vesicle http://togogenome.org/gene/9685:TOM1L2 ^@ http://purl.uniprot.org/uniprot/A0A337S5I1|||http://purl.uniprot.org/uniprot/A0A337SEP7|||http://purl.uniprot.org/uniprot/M3WRU6 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9685:MINAR2 ^@ http://purl.uniprot.org/uniprot/M3W9L2 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9685:SLC35F2 ^@ http://purl.uniprot.org/uniprot/A6XMY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9685:CERS5 ^@ http://purl.uniprot.org/uniprot/M3WBH9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9685:STXBP3 ^@ http://purl.uniprot.org/uniprot/M3WQB8 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9685:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/A0A337SBS2|||http://purl.uniprot.org/uniprot/M3WY00 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/9685:LOC101098254 ^@ http://purl.uniprot.org/uniprot/M3WJD9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/9685:PIK3CB ^@ http://purl.uniprot.org/uniprot/M3VZ77 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9685:MPPE1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UL78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallophosphoesterase superfamily. MPPE1 family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Interacts with GPI-anchor proteins. Interacts with TMED10.|||Membrane|||Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.|||cis-Golgi network membrane http://togogenome.org/gene/9685:UROS ^@ http://purl.uniprot.org/uniprot/A0A5F5Y1J7 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/9685:ITGAL ^@ http://purl.uniprot.org/uniprot/M3WC52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9685:LOC101098042 ^@ http://purl.uniprot.org/uniprot/A0A2I2USR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9685:LOC101096784 ^@ http://purl.uniprot.org/uniprot/M3WDA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:LOC101092885 ^@ http://purl.uniprot.org/uniprot/M3X1N2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:GNG11 ^@ http://purl.uniprot.org/uniprot/A0A2I2U3C1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9685:HNF4A ^@ http://purl.uniprot.org/uniprot/M3W941 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9685:SLC24A5 ^@ http://purl.uniprot.org/uniprot/M3X5I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9685:ECI1 ^@ http://purl.uniprot.org/uniprot/M3W858 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9685:TIMM17A ^@ http://purl.uniprot.org/uniprot/M3WWG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:SNX17 ^@ http://purl.uniprot.org/uniprot/A0A337SPJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9685:AQR ^@ http://purl.uniprot.org/uniprot/M3WK08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWF11 family.|||Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.|||Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.|||Nucleus http://togogenome.org/gene/9685:LOC101092190 ^@ http://purl.uniprot.org/uniprot/M3WX61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9685:KRTCAP3 ^@ http://purl.uniprot.org/uniprot/M3W3L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9685:CDK5RAP1 ^@ http://purl.uniprot.org/uniprot/M3WM53 ^@ Similarity ^@ Belongs to the methylthiotransferase family. MiaB subfamily. http://togogenome.org/gene/9685:PRND ^@ http://purl.uniprot.org/uniprot/M3VWQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:CLDN25 ^@ http://purl.uniprot.org/uniprot/M3X7L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9685:BCLAF1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYH7|||http://purl.uniprot.org/uniprot/A0A2I2V1P3 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9685:PSMB3 ^@ http://purl.uniprot.org/uniprot/M3WKT6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:SEC24A ^@ http://purl.uniprot.org/uniprot/A0A2I2UJD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9685:VARS2 ^@ http://purl.uniprot.org/uniprot/A0A337SC93|||http://purl.uniprot.org/uniprot/A0A5F5XT10|||http://purl.uniprot.org/uniprot/M3WDF9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:CE2H19orf54 ^@ http://purl.uniprot.org/uniprot/M3WP95 ^@ Similarity ^@ Belongs to the ACTMAP family. http://togogenome.org/gene/9685:CACNB1 ^@ http://purl.uniprot.org/uniprot/A0A5F5XGW6|||http://purl.uniprot.org/uniprot/M3WCG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/9685:TPRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V4X0 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9685:PTGES3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p23/wos2 family.|||Cytoplasm|||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.|||Forms a complex with HSP70, HSP90 and other chaperones. http://togogenome.org/gene/9685:TM9SF4 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPX5|||http://purl.uniprot.org/uniprot/A0A5F5XIC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9685:MFSD1 ^@ http://purl.uniprot.org/uniprot/A0A337SHA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:PARD3B ^@ http://purl.uniprot.org/uniprot/A0A337SQS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR3 family.|||Cell junction|||Endomembrane system http://togogenome.org/gene/9685:IL17RB ^@ http://purl.uniprot.org/uniprot/M3W4E6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:FAM161B ^@ http://purl.uniprot.org/uniprot/M3WGJ6 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9685:TFCP2 ^@ http://purl.uniprot.org/uniprot/M3XA11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9685:SPAST ^@ http://purl.uniprot.org/uniprot/A0A2I2U639|||http://purl.uniprot.org/uniprot/M3X3B7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.|||Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.|||Belongs to the AAA ATPase family. Spastin subfamily.|||Cytoplasm|||Endoplasmic reticulum|||Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.|||Membrane|||Midbody|||Nucleus|||axon|||centrosome|||cytoskeleton|||perinuclear region|||spindle http://togogenome.org/gene/9685:MRPL35 ^@ http://purl.uniprot.org/uniprot/A0A337SMX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/9685:FAM76B ^@ http://purl.uniprot.org/uniprot/M3XA68 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/9685:AP3M2 ^@ http://purl.uniprot.org/uniprot/A0A337RT59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/9685:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A2I2U4L2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9685:NELL1 ^@ http://purl.uniprot.org/uniprot/A0A337RXS0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:PREP ^@ http://purl.uniprot.org/uniprot/M3W3E3 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9685:CERS2 ^@ http://purl.uniprot.org/uniprot/A0A337SX67 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9685:THBS2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UG29 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:RPS16 ^@ http://purl.uniprot.org/uniprot/M3WDU7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9685:LOC101099773 ^@ http://purl.uniprot.org/uniprot/M3WI84 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9685:LMX1B ^@ http://purl.uniprot.org/uniprot/M3VWN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:OPRM1 ^@ http://purl.uniprot.org/uniprot/M3W3Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Endosome|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/9685:GOT1L1 ^@ http://purl.uniprot.org/uniprot/M3WMT6 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/9685:RPS29 ^@ http://purl.uniprot.org/uniprot/A0A337SCP7 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9685:UTP23 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIZ8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9685:TTYH2 ^@ http://purl.uniprot.org/uniprot/M3WE23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/9685:MTCP1 ^@ http://purl.uniprot.org/uniprot/M3X1T5 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9685:STRADA ^@ http://purl.uniprot.org/uniprot/M3W0G1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9685:GFM1 ^@ http://purl.uniprot.org/uniprot/M3WIL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/9685:RAB33A ^@ http://purl.uniprot.org/uniprot/A0A2I2UDD0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9685:TAF1A ^@ http://purl.uniprot.org/uniprot/M3VY62 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9685:LOC101101377 ^@ http://purl.uniprot.org/uniprot/A0A2I2UHU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UI28|||http://purl.uniprot.org/uniprot/A0A337SQT3|||http://purl.uniprot.org/uniprot/M3X809 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9685:ARSB ^@ http://purl.uniprot.org/uniprot/P33727 ^@ Activity Regulation|||Cofactor|||Disease Annotation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Defects in ARSB are the cause of mucopolysaccharidosis type VI (MPS-VI). MPS-VI has been described in Siamese cats (PubMed:6794375).|||Homodimer.|||Inhibited by ethanol (By similarity).|||Lysosome|||Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9685:LOC493739 ^@ http://purl.uniprot.org/uniprot/Q5VFH6 ^@ Allergen|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Abundant in urine (at protein level).|||Belongs to the calycin superfamily. Lipocalin family.|||Causes an allergic reaction in human. Binds to IgE.|||May be a pheromone carrier. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice.|||Secreted http://togogenome.org/gene/9685:TMEM120B ^@ http://purl.uniprot.org/uniprot/M3WID3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM120 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9685:PDK4 ^@ http://purl.uniprot.org/uniprot/M3WTN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9685:BCL2L1 ^@ http://purl.uniprot.org/uniprot/Q8SQ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9685:PLP2 ^@ http://purl.uniprot.org/uniprot/M3W114 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:HEPHL1 ^@ http://purl.uniprot.org/uniprot/M3WL87 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9685:FGD3 ^@ http://purl.uniprot.org/uniprot/M3WM03 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:MRPS14 ^@ http://purl.uniprot.org/uniprot/M3XDB6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9685:LOC101101603 ^@ http://purl.uniprot.org/uniprot/A0A337SQ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IGFL family.|||Secreted http://togogenome.org/gene/9685:CCNI ^@ http://purl.uniprot.org/uniprot/M3W0P9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9685:RNF185 ^@ http://purl.uniprot.org/uniprot/A0A337SFW9 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9685:HCN3 ^@ http://purl.uniprot.org/uniprot/M3X2X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101092497 ^@ http://purl.uniprot.org/uniprot/A0A2I2UDE9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9685:FLVCR2 ^@ http://purl.uniprot.org/uniprot/M3WK96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TNRC6A ^@ http://purl.uniprot.org/uniprot/A0A2I2US95|||http://purl.uniprot.org/uniprot/A0A5F5XLL1|||http://purl.uniprot.org/uniprot/A0A5F5Y1J3 ^@ Similarity ^@ Belongs to the GW182 family. http://togogenome.org/gene/9685:SLC19A3 ^@ http://purl.uniprot.org/uniprot/K7REM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/9685:RFT1 ^@ http://purl.uniprot.org/uniprot/M3XCV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/9685:TMC3 ^@ http://purl.uniprot.org/uniprot/M3WJT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9685:CNOT6 ^@ http://purl.uniprot.org/uniprot/M3VXG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:ANXA5 ^@ http://purl.uniprot.org/uniprot/M3W269 ^@ Domain|||Function|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. http://togogenome.org/gene/9685:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/M3W6D1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9685:MED25 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1I3|||http://purl.uniprot.org/uniprot/A0A5F5Y0E7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 25 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9685:SLC66A2 ^@ http://purl.uniprot.org/uniprot/A0A337STD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GGPS1 ^@ http://purl.uniprot.org/uniprot/M3W9L8 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9685:AMBP ^@ http://purl.uniprot.org/uniprot/E1CJT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Cell membrane|||Endoplasmic reticulum|||In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.|||Membrane|||Mitochondrion inner membrane|||Monomer. Also occurs as a complex with tryptase in mast cells.|||Nucleus membrane|||cytosol|||extracellular matrix http://togogenome.org/gene/9685:LOC101099477 ^@ http://purl.uniprot.org/uniprot/M3WZD7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:RPL23A ^@ http://purl.uniprot.org/uniprot/M3W1E8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9685:EMC9 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJ90 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9685:SRM ^@ http://purl.uniprot.org/uniprot/M3WN08 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9685:RNF31 ^@ http://purl.uniprot.org/uniprot/M3W4B9 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9685:NSG2 ^@ http://purl.uniprot.org/uniprot/M3XC96 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9685:MOCS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U4C9|||http://purl.uniprot.org/uniprot/M3W5V6 ^@ Similarity ^@ In the C-terminal section; belongs to the MoaC family.|||In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. http://togogenome.org/gene/9685:TMOD3 ^@ http://purl.uniprot.org/uniprot/M3WH67 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:DTNA ^@ http://purl.uniprot.org/uniprot/A0A2I2U492|||http://purl.uniprot.org/uniprot/A0A2I2UFA8|||http://purl.uniprot.org/uniprot/A0A337SSP0|||http://purl.uniprot.org/uniprot/M3WF72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9685:ELMO1 ^@ http://purl.uniprot.org/uniprot/M3W2J8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9685:KLRAP1 ^@ http://purl.uniprot.org/uniprot/Q863K4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GUCY2C ^@ http://purl.uniprot.org/uniprot/A0A2I2U408 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9685:SGCE ^@ http://purl.uniprot.org/uniprot/A0A2I2V396|||http://purl.uniprot.org/uniprot/M3X4B9 ^@ Function|||Similarity ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. http://togogenome.org/gene/9685:SLC24A4 ^@ http://purl.uniprot.org/uniprot/M3W8K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9685:BRS3 ^@ http://purl.uniprot.org/uniprot/M3X3W7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/9685:MAS1 ^@ http://purl.uniprot.org/uniprot/M3VZ92 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9685:CDCA7 ^@ http://purl.uniprot.org/uniprot/A0A2I2UTQ8|||http://purl.uniprot.org/uniprot/M3W450 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:CWF19L1 ^@ http://purl.uniprot.org/uniprot/M3WDJ5 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9685:IAPP ^@ http://purl.uniprot.org/uniprot/P12967 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calcitonin family.|||Interacts with IDE and INS.|||Secreted|||Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.|||The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. http://togogenome.org/gene/9685:UHRF2 ^@ http://purl.uniprot.org/uniprot/M3WUP3 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/9685:PSMC2 ^@ http://purl.uniprot.org/uniprot/M3VV51 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9685:CNOT1 ^@ http://purl.uniprot.org/uniprot/M3X382 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT1 family.|||Nucleus http://togogenome.org/gene/9685:LOC101091265 ^@ http://purl.uniprot.org/uniprot/A0A5F5XTX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9685:GRM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UA64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:METTL26 ^@ http://purl.uniprot.org/uniprot/M3X3I7 ^@ Similarity ^@ Belongs to the UPF0585 family. http://togogenome.org/gene/9685:ANO9 ^@ http://purl.uniprot.org/uniprot/A0A2I2U1T0|||http://purl.uniprot.org/uniprot/A0A337SQ10 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:KRT78 ^@ http://purl.uniprot.org/uniprot/M3VUH1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9685:LOC101083349 ^@ http://purl.uniprot.org/uniprot/M3WX52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:CLCN1 ^@ http://purl.uniprot.org/uniprot/A0A059WLP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:STK10 ^@ http://purl.uniprot.org/uniprot/M3VUR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Cell membrane http://togogenome.org/gene/9685:CACNG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UYC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9685:KHDRBS3 ^@ http://purl.uniprot.org/uniprot/M3VUB9 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9685:RPS6KB2 ^@ http://purl.uniprot.org/uniprot/M3W099 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9685:ITGAE ^@ http://purl.uniprot.org/uniprot/Q8MKF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9685:OSBPL9 ^@ http://purl.uniprot.org/uniprot/A0A337S5J8|||http://purl.uniprot.org/uniprot/M3WD14 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9685:HKDC1 ^@ http://purl.uniprot.org/uniprot/M3W345 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9685:CPQ ^@ http://purl.uniprot.org/uniprot/A0A5F5XP07|||http://purl.uniprot.org/uniprot/A0A5F5Y2I4|||http://purl.uniprot.org/uniprot/M3WQN1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome http://togogenome.org/gene/9685:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/M3WJN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9685:LOC101085531 ^@ http://purl.uniprot.org/uniprot/A0A2I2UIV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9685:MNAT1 ^@ http://purl.uniprot.org/uniprot/M3X1W4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/9685:PPY ^@ http://purl.uniprot.org/uniprot/A0A0A0MQ26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9685:PGK1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UJH0 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/9685:GTF2H1 ^@ http://purl.uniprot.org/uniprot/M3W751 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/9685:GTF2A1L ^@ http://purl.uniprot.org/uniprot/M3X196 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9685:CDK7 ^@ http://purl.uniprot.org/uniprot/M3W2X7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9685:LOC101081111 ^@ http://purl.uniprot.org/uniprot/M3X731 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:RAD18 ^@ http://purl.uniprot.org/uniprot/A0A5F5XU25|||http://purl.uniprot.org/uniprot/M3XD01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD18 family.|||Nucleus http://togogenome.org/gene/9685:RO60 ^@ http://purl.uniprot.org/uniprot/A0A2I2ULJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9685:GIPC2 ^@ http://purl.uniprot.org/uniprot/A0A2I2UF05 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9685:VIPR2 ^@ http://purl.uniprot.org/uniprot/M3WAP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:USP33 ^@ http://purl.uniprot.org/uniprot/M3WZ44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9685:SAMD8 ^@ http://purl.uniprot.org/uniprot/A0A2I2V437 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9685:ANAPC10 ^@ http://purl.uniprot.org/uniprot/M3WVJ2 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9685:PRAME ^@ http://purl.uniprot.org/uniprot/A0A5F5Y623 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9685:NKTR ^@ http://purl.uniprot.org/uniprot/A0A337SDZ8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9685:PEX14 ^@ http://purl.uniprot.org/uniprot/A0A2I2UBI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.|||Peroxisome membrane http://togogenome.org/gene/9685:TJP2 ^@ http://purl.uniprot.org/uniprot/M3WA99 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9685:STAMBP ^@ http://purl.uniprot.org/uniprot/M3WGC0 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9685:IFNW11 ^@ http://purl.uniprot.org/uniprot/Q0GYU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9685:MBOAT7 ^@ http://purl.uniprot.org/uniprot/A0A337SSR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:GRM7 ^@ http://purl.uniprot.org/uniprot/A0A337SEA2|||http://purl.uniprot.org/uniprot/A0A337SVS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:CHRM4 ^@ http://purl.uniprot.org/uniprot/M3XFA6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9685:INSL3 ^@ http://purl.uniprot.org/uniprot/A0A2I2URJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted|||Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. http://togogenome.org/gene/9685:TMEM87A ^@ http://purl.uniprot.org/uniprot/M3WU12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:TREX2 ^@ http://purl.uniprot.org/uniprot/M3WNU8 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/9685:LOC101092136 ^@ http://purl.uniprot.org/uniprot/M3X3N8 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9685:YARS2 ^@ http://purl.uniprot.org/uniprot/M3W3W2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9685:GLA ^@ http://purl.uniprot.org/uniprot/A0A2I2U1V5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9685:INHA ^@ http://purl.uniprot.org/uniprot/M3W6A9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9685:CREBL2 ^@ http://purl.uniprot.org/uniprot/M3X0E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9685:LDHA ^@ http://purl.uniprot.org/uniprot/A0A337S8L1 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9685:HOMEZ ^@ http://purl.uniprot.org/uniprot/A0A2I2US91 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:PSMD7 ^@ http://purl.uniprot.org/uniprot/M3WTN9 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/9685:QRSL1 ^@ http://purl.uniprot.org/uniprot/M3W3G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9685:GPRC5C ^@ http://purl.uniprot.org/uniprot/A0A2I2UI30 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:ADAT2 ^@ http://purl.uniprot.org/uniprot/M3WX78 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/9685:OLFML2A ^@ http://purl.uniprot.org/uniprot/M3W012 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:TGIF2 ^@ http://purl.uniprot.org/uniprot/M3X8Q8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:AVL9 ^@ http://purl.uniprot.org/uniprot/M3W850 ^@ Subcellular Location Annotation ^@ Recycling endosome http://togogenome.org/gene/9685:PPP1R1C ^@ http://purl.uniprot.org/uniprot/A0A2I2U0J1|||http://purl.uniprot.org/uniprot/A0A2I2UJI1 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9685:POU2F1 ^@ http://purl.uniprot.org/uniprot/A0A337SFE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9685:SYT14 ^@ http://purl.uniprot.org/uniprot/A0A337RY76|||http://purl.uniprot.org/uniprot/A0A337SJR0 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9685:CA1H5orf24 ^@ http://purl.uniprot.org/uniprot/A0A2I2U5P3 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9685:SUPT20H ^@ http://purl.uniprot.org/uniprot/A0A337SX72|||http://purl.uniprot.org/uniprot/M3W111 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/9685:PNOC ^@ http://purl.uniprot.org/uniprot/M3X9I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Secreted http://togogenome.org/gene/9685:LOC101100898 ^@ http://purl.uniprot.org/uniprot/M3WRP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:TAFA5 ^@ http://purl.uniprot.org/uniprot/A0A337SES7 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9685:PLXNB2 ^@ http://purl.uniprot.org/uniprot/M3WG01 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:PRNP ^@ http://purl.uniprot.org/uniprot/B2LVH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Golgi apparatus|||Membrane http://togogenome.org/gene/9685:LSM12 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQ30 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/9685:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUU7|||http://purl.uniprot.org/uniprot/A0A337SJX3|||http://purl.uniprot.org/uniprot/A0A5F5XW86|||http://purl.uniprot.org/uniprot/M3WRB1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9685:LOC105260531 ^@ http://purl.uniprot.org/uniprot/A0A2I2UQQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PIK3C3 ^@ http://purl.uniprot.org/uniprot/M3XFX9 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9685:SSR3 ^@ http://purl.uniprot.org/uniprot/M3X2V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9685:GDAP2 ^@ http://purl.uniprot.org/uniprot/M3W0E2 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/9685:EPHB4 ^@ http://purl.uniprot.org/uniprot/A0A2I2V293|||http://purl.uniprot.org/uniprot/M3W6L6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9685:RHBDL2 ^@ http://purl.uniprot.org/uniprot/M3VZX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9685:EIF2S2 ^@ http://purl.uniprot.org/uniprot/M3WX80 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9685:FOLH1B ^@ http://purl.uniprot.org/uniprot/A0A337SB41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:LOC101096691 ^@ http://purl.uniprot.org/uniprot/M3X2L0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PPP2R5C ^@ http://purl.uniprot.org/uniprot/A0A337S4F6 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9685:SH3BP5L ^@ http://purl.uniprot.org/uniprot/M3X7J8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9685:WASF2 ^@ http://purl.uniprot.org/uniprot/M3W8J1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9685:ANAPC16 ^@ http://purl.uniprot.org/uniprot/A0A2I2UKW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/9685:ADCY8 ^@ http://purl.uniprot.org/uniprot/A0A2I2UI83|||http://purl.uniprot.org/uniprot/A0A337S2A8|||http://purl.uniprot.org/uniprot/M3W5W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9685:NMUR2 ^@ http://purl.uniprot.org/uniprot/M3WGI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9685:HMOX2 ^@ http://purl.uniprot.org/uniprot/M3WGV3 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9685:MANEA ^@ http://purl.uniprot.org/uniprot/A0A2I2UKA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:LAMP1 ^@ http://purl.uniprot.org/uniprot/C6GGN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9685:MMP20 ^@ http://purl.uniprot.org/uniprot/M3WN98 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9685:ABLIM1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UAW4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:DCK ^@ http://purl.uniprot.org/uniprot/M3X133 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9685:NMNAT2 ^@ http://purl.uniprot.org/uniprot/A0A337S342 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9685:LOC101084636 ^@ http://purl.uniprot.org/uniprot/A0A337STW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9685:AVPI1 ^@ http://purl.uniprot.org/uniprot/M3WWB2 ^@ Function ^@ May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. http://togogenome.org/gene/9685:CYFIP1 ^@ http://purl.uniprot.org/uniprot/M3WIC1 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/9685:PRPS2 ^@ http://purl.uniprot.org/uniprot/M3WGN3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9685:UBR2 ^@ http://purl.uniprot.org/uniprot/M3X4Z3 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9685:PLXNB1 ^@ http://purl.uniprot.org/uniprot/M3VXW2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:VWF ^@ http://purl.uniprot.org/uniprot/A0A061DD19 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.|||Multimeric. Interacts with F8.|||Secreted|||extracellular matrix http://togogenome.org/gene/9685:PRR5L ^@ http://purl.uniprot.org/uniprot/A0A2I2UIE8 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9685:GALNT6 ^@ http://purl.uniprot.org/uniprot/M3W249 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9685:ARAP2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U0R4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9685:PSKH1 ^@ http://purl.uniprot.org/uniprot/M3WZQ5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9685:UCHL3 ^@ http://purl.uniprot.org/uniprot/A0A337S3N7 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9685:ATF1 ^@ http://purl.uniprot.org/uniprot/M3WJP1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ADRA2A ^@ http://purl.uniprot.org/uniprot/Q27RP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:RAP2A ^@ http://purl.uniprot.org/uniprot/A0A2I2UK19 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9685:NDUFA2 ^@ http://purl.uniprot.org/uniprot/M3VWC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:SLC19A2 ^@ http://purl.uniprot.org/uniprot/Q27PN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||High-affinity transporter for the intake of thiamine. http://togogenome.org/gene/9685:KEF43_p12 ^@ http://purl.uniprot.org/uniprot/P48905 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 2 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101094311 ^@ http://purl.uniprot.org/uniprot/M3X4Y3 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/9685:STXBP5 ^@ http://purl.uniprot.org/uniprot/M3WC49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9685:YWHAZ ^@ http://purl.uniprot.org/uniprot/M3WVC7 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9685:AWAT1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UB18 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:KDM4A ^@ http://purl.uniprot.org/uniprot/M3WLZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9685:PEX12 ^@ http://purl.uniprot.org/uniprot/M3WD63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9685:S100A1 ^@ http://purl.uniprot.org/uniprot/M3XA34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Mitochondrion http://togogenome.org/gene/9685:CDKAL1 ^@ http://purl.uniprot.org/uniprot/J7M797|||http://purl.uniprot.org/uniprot/M3W7B3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9685:ASF1B ^@ http://purl.uniprot.org/uniprot/M3X9K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9685:MDM2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U893|||http://purl.uniprot.org/uniprot/Q7YRZ8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoubiquitination leads to proteasomal degradation; resulting in p53/TP53 activation it may be regulated by SFN. Also ubiquitinated by TRIM13. Deubiquitinated by USP2 leads to its accumulation and increases deubiquitination and degradation of p53/TP53. Deubiquitinated by USP7 leading to its stabilization.|||Belongs to the MDM2/MDM4 family.|||Cytoplasm|||E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity).|||Interacts with p53/TP53, TP73/p73, RBL5 and RP11. Binds specifically to RNA. Can interact with RB1, E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX. Interacts with CDKN2AIP, RFWD3, USP7, PYHIN1 and RBBP6. Interacts with ARRB1 and ARRB2. Interacts with PSMA3. Found in a trimeric complex with MDM2, MDM4 and USP2. Interacts with USP2 (via N-terminus and C-terminus). Interacts with MDM4. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts directly with DAXX and USP7. Interacts (via C-terminus) with RASSF1 isoform A (via N-terminus); the interaction is independent of TP53. Interacts with APEX1; leading to its ubiquitination and degradation. Interacts with RYBP; this inhibits ubiquitination of TP53. Identified in a complex with RYBP and p53/TP53. Also a component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in regulating p53/TP53 stabilization and activity. Binds directly both p53/TP53 and TRIM28. Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor responses with DNA damage. Interacts directly with both TRIM28 and ERBB4 in the complex. Interacts with DYRK2. Interacts with IGF1R. Interacts with TRIM13; the interaction ubiquitinates MDM2 leading to its proteasomal degradation. Interacts with SNAI1; this interaction promotes SNAI1 ubiquitination. Interacts with NOTCH1 (via intracellular domain). Interacts with FHIT. Interacts with RFFL and RNF34; the interaction stabilizes MDM2. Interacts with CDK5RAP3 and CDKN2A/ARF; form a ternary complex involved in regulation of p53/TP53. Interacts with MTA1. Interacts with AARB2. Interacts with MTBP. Interacts with PML. Interacts with RPL11. Interacts with TBRG1. Interacts with the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11; the interaction is direct occurs in the nucleoplasm and negatively regulates MDM2-mediated TP53 ubiquitination and degradation. Interacts with ADGRB1; the interaction results in inhibition of MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity. Interacts with RPL23A; this interaction may promote p53/TP53 polyubiquitination (By similarity). Interacts with NDUFS1 (By similarity). Interacts with MORN3; the interaction enhances the ubiquitination of p53/TP53 (By similarity).|||Nucleus|||Phosphorylation on Ser-166 by SGK1 activates ubiquitination of p53/TP53. Phosphorylated at multiple sites near the RING domain by ATM upon DNA damage; this prevents oligomerization and E3 ligase processivity and impedes constitutive p53/TP53 degradation (By similarity).|||Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself (By similarity).|||nucleolus|||nucleoplasm http://togogenome.org/gene/9685:CA11 ^@ http://purl.uniprot.org/uniprot/A0A2I2U026 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9685:NUP50 ^@ http://purl.uniprot.org/uniprot/M3WZW1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9685:MAD1L1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y2P6 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/9685:FELCATV1R11 ^@ http://purl.uniprot.org/uniprot/M3WXH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:PTCH2 ^@ http://purl.uniprot.org/uniprot/M3WCG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/9685:GNRH1 ^@ http://purl.uniprot.org/uniprot/M3X2M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. http://togogenome.org/gene/9685:KEF43_p01 ^@ http://purl.uniprot.org/uniprot/P48886 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme b groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.|||The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. http://togogenome.org/gene/9685:PAPSS1 ^@ http://purl.uniprot.org/uniprot/A0A2I2U875 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9685:LOC101086252 ^@ http://purl.uniprot.org/uniprot/M3X8C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:HTR1A ^@ http://purl.uniprot.org/uniprot/M3WJQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.|||Membrane|||dendrite http://togogenome.org/gene/9685:CLEC12A ^@ http://purl.uniprot.org/uniprot/M3X0Z4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A2I2U6X6 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9685:INO80C ^@ http://purl.uniprot.org/uniprot/M3W031 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:EIF2S1 ^@ http://purl.uniprot.org/uniprot/M3WYU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9685:THPO ^@ http://purl.uniprot.org/uniprot/C6EMY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/9685:SEPSECS ^@ http://purl.uniprot.org/uniprot/M3X7Z6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/9685:GSDMA ^@ http://purl.uniprot.org/uniprot/M3WLQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9685:STAG2 ^@ http://purl.uniprot.org/uniprot/A0A337ST49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9685:NOP10 ^@ http://purl.uniprot.org/uniprot/A0A2I2U315 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9685:FAM219A ^@ http://purl.uniprot.org/uniprot/A0A2I2U7R5 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9685:THNSL1 ^@ http://purl.uniprot.org/uniprot/M3X8W6 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9685:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A337SEM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/9685:ATP6V0B ^@ http://purl.uniprot.org/uniprot/M3W601 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9685:SLC2A3 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUL1|||http://purl.uniprot.org/uniprot/A0A5F5XSG5|||http://purl.uniprot.org/uniprot/M3VWZ7 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Cell projection|||Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Perikaryon|||Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. http://togogenome.org/gene/9685:LOC101101145 ^@ http://purl.uniprot.org/uniprot/M3XG37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:KCNH3 ^@ http://purl.uniprot.org/uniprot/M3WLB8 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9685:PPARG ^@ http://purl.uniprot.org/uniprot/A0A337SSZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/9685:POU5F1 ^@ http://purl.uniprot.org/uniprot/D3U664 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9685:UBA2 ^@ http://purl.uniprot.org/uniprot/M3X2D9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-activating E1 family.|||Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.|||Nucleus|||The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. http://togogenome.org/gene/9685:DOK3 ^@ http://purl.uniprot.org/uniprot/M3X6K9 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/9685:IL2 ^@ http://purl.uniprot.org/uniprot/Q07885 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9685:KIF5C ^@ http://purl.uniprot.org/uniprot/A0A2I2U7N8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9685:TBX15 ^@ http://purl.uniprot.org/uniprot/A0A2I2UY24 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9685:LTC4S ^@ http://purl.uniprot.org/uniprot/M3WPR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:BCAR1 ^@ http://purl.uniprot.org/uniprot/M3WMG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9685:LOC101081091 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9685:IL1RL1 ^@ http://purl.uniprot.org/uniprot/M3WRI0 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9685:FOXA2 ^@ http://purl.uniprot.org/uniprot/M3WGT1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:NHEJ1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XLF subfamily.|||Nucleus http://togogenome.org/gene/9685:CA4 ^@ http://purl.uniprot.org/uniprot/M3WAR8 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9685:IDH3G ^@ http://purl.uniprot.org/uniprot/A0A2I2V4K1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9685:RPL30 ^@ http://purl.uniprot.org/uniprot/M3VY11 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9685:ART3 ^@ http://purl.uniprot.org/uniprot/A0A5F5Y767 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9685:ATP6V0C ^@ http://purl.uniprot.org/uniprot/A0A5F5XUE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9685:FABP3 ^@ http://purl.uniprot.org/uniprot/M3X9Z0 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9685:MRPS26 ^@ http://purl.uniprot.org/uniprot/M3X130 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS26 family.|||Mitochondrion http://togogenome.org/gene/9685:PSMA5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UNM4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9685:ADAM17 ^@ http://purl.uniprot.org/uniprot/M3W8I1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9685:NBL1 ^@ http://purl.uniprot.org/uniprot/A0A2I2UVF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9685:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2I2U295|||http://purl.uniprot.org/uniprot/M3W9U1 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9685:COPS7A ^@ http://purl.uniprot.org/uniprot/M3XEA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9685:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A337SPI8|||http://purl.uniprot.org/uniprot/A0A5F5Y427|||http://purl.uniprot.org/uniprot/M3W590 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9685:PHKG2 ^@ http://purl.uniprot.org/uniprot/M3WC60 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9685:FSCN3 ^@ http://purl.uniprot.org/uniprot/M3W455 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9685:SPR ^@ http://purl.uniprot.org/uniprot/A0A2I2UR05 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/9685:HMGN3 ^@ http://purl.uniprot.org/uniprot/A0A337SCE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9685:LOC101088329 ^@ http://purl.uniprot.org/uniprot/M3XEP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9685:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V0F1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9685:HACD3 ^@ http://purl.uniprot.org/uniprot/M3WA17 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9685:EXTL3 ^@ http://purl.uniprot.org/uniprot/M3WRR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9685:CYP11A1 ^@ http://purl.uniprot.org/uniprot/M3WE36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Mitochondrion inner membrane http://togogenome.org/gene/9685:LOC101096750 ^@ http://purl.uniprot.org/uniprot/M3XBL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/9685:RBFOX3 ^@ http://purl.uniprot.org/uniprot/M3VYQ8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/9685:MYH7 ^@ http://purl.uniprot.org/uniprot/M3WAS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||myofibril http://togogenome.org/gene/9685:LOC101100916 ^@ http://purl.uniprot.org/uniprot/M3WZH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9685:PPP2R5A ^@ http://purl.uniprot.org/uniprot/M3X5Y6 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9685:GPR146 ^@ http://purl.uniprot.org/uniprot/M3WF25 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9685:RPS4X ^@ http://purl.uniprot.org/uniprot/P62705 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS4 family.|||Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9685:DR1 ^@ http://purl.uniprot.org/uniprot/M3WGZ8 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9685:OASL ^@ http://purl.uniprot.org/uniprot/M3WBT8 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/9685:RPIA ^@ http://purl.uniprot.org/uniprot/A0A2I2U7J2|||http://purl.uniprot.org/uniprot/M3W8G6 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/9685:NUP133 ^@ http://purl.uniprot.org/uniprot/A0A5F5XER8|||http://purl.uniprot.org/uniprot/M3VVR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/9685:GANAB ^@ http://purl.uniprot.org/uniprot/M3WAD1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9685:SMIM14 ^@ http://purl.uniprot.org/uniprot/A0A2I2V3P0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9685:IDUA ^@ http://purl.uniprot.org/uniprot/A0A097HWG4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 39 family. http://togogenome.org/gene/9685:FBXO45 ^@ http://purl.uniprot.org/uniprot/A0A2I2UCE9 ^@ Similarity ^@ Belongs to the FBXO45/Fsn family. http://togogenome.org/gene/9685:POU3F4 ^@ http://purl.uniprot.org/uniprot/M3WG36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/9685:GGACT ^@ http://purl.uniprot.org/uniprot/M3WQ38 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/9685:ARMC8 ^@ http://purl.uniprot.org/uniprot/A0A2I2UPD5|||http://purl.uniprot.org/uniprot/M3VXL8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9685:BTD ^@ http://purl.uniprot.org/uniprot/M3WEV4 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9685:ALKBH5 ^@ http://purl.uniprot.org/uniprot/A0A2I2UW44 ^@ Subcellular Location Annotation|||Subunit ^@ Monomer.|||Nucleus speckle http://togogenome.org/gene/9685:CALHM1 ^@ http://purl.uniprot.org/uniprot/M3VYF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9685:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/A0A2I2U8A9 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/9685:TP63 ^@ http://purl.uniprot.org/uniprot/A0A2I2UUR1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Mitochondrion matrix|||Nucleus|||PML body|||centrosome http://togogenome.org/gene/9685:ZSCAN26 ^@ http://purl.uniprot.org/uniprot/M3X7M7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9685:ITGB7 ^@ http://purl.uniprot.org/uniprot/M3W4V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||Recycling endosome|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9685:FAM3D ^@ http://purl.uniprot.org/uniprot/M3W626 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9685:CD151 ^@ http://purl.uniprot.org/uniprot/M3VZU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9685:TLN1 ^@ http://purl.uniprot.org/uniprot/M3WHI4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9685:TNP2 ^@ http://purl.uniprot.org/uniprot/B3LF33 ^@ Function|||Similarity ^@ Belongs to the nuclear transition protein 2 family.|||Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. http://togogenome.org/gene/9685:SLC2A1 ^@ http://purl.uniprot.org/uniprot/M3W576 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/9685:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A2I2UZM8|||http://purl.uniprot.org/uniprot/M3W6Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9685:DDB1 ^@ http://purl.uniprot.org/uniprot/M3XDV7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDB1 family.|||Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.|||Component of the UV-DDB complex.|||Nucleus|||The core of the protein consists of three WD40 beta-propeller domains. http://togogenome.org/gene/9685:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/A0A2I2V1M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9685:HSD3B2 ^@ http://purl.uniprot.org/uniprot/F5CSS4 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9685:PIP ^@ http://purl.uniprot.org/uniprot/A0A337SBR4 ^@ Similarity|||Subunit ^@ Belongs to the PIP family.|||Monomer. Interacts with AZGP1. http://togogenome.org/gene/9685:ALAD ^@ http://purl.uniprot.org/uniprot/M3WB25 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer; active form. Homohexamer; low activity form. http://togogenome.org/gene/9685:NFIL3 ^@ http://purl.uniprot.org/uniprot/M3WIX7 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/9685:COG2 ^@ http://purl.uniprot.org/uniprot/M3WJ10 ^@ Similarity ^@ Belongs to the COG2 family.