http://togogenome.org/gene/9796:AMELX ^@ http://purl.uniprot.org/uniprot/F6QHS4 ^@ Similarity ^@ Belongs to the amelogenin family. http://togogenome.org/gene/9796:KCNT2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GT19|||http://purl.uniprot.org/uniprot/A0A5F5Q273 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:SPI2 ^@ http://purl.uniprot.org/uniprot/B5BV00|||http://purl.uniprot.org/uniprot/P38029 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the serpin family.|||Inhibitor of serine proteases.|||N-glycosylated with carbohydrates having biantennary side chains.|||Plasma.|||Secreted|||The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the active site of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). http://togogenome.org/gene/9796:ACER2 ^@ http://purl.uniprot.org/uniprot/F6XSP1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:MRPL34 ^@ http://purl.uniprot.org/uniprot/A0A9L0RBF5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/9796:MIF ^@ http://purl.uniprot.org/uniprot/F6S243 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/9796:TFEC ^@ http://purl.uniprot.org/uniprot/A0A3Q2GUC0|||http://purl.uniprot.org/uniprot/A0A3Q2I9X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9796:MPP6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RJN9|||http://purl.uniprot.org/uniprot/A0A9L0SF23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane http://togogenome.org/gene/9796:UTP14A ^@ http://purl.uniprot.org/uniprot/F6UWY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP14 family.|||nucleolus http://togogenome.org/gene/9796:COX7B2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TDN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:ABCA1 ^@ http://purl.uniprot.org/uniprot/F6QSK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:FAM122A ^@ http://purl.uniprot.org/uniprot/A0A9L0TGW3 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9796:GJB4 ^@ http://purl.uniprot.org/uniprot/A0A654IF82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:NDUFB4 ^@ http://purl.uniprot.org/uniprot/A0A9L0RIM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A9L0SIL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:MCM8 ^@ http://purl.uniprot.org/uniprot/A0A9L0RQP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9796:PRR15L ^@ http://purl.uniprot.org/uniprot/A0A9L0SUZ4|||http://purl.uniprot.org/uniprot/F6V1F6 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9796:BEST1 ^@ http://purl.uniprot.org/uniprot/F6WEA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9796:MFSD8 ^@ http://purl.uniprot.org/uniprot/A0A9L0R515 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:RNF34 ^@ http://purl.uniprot.org/uniprot/A0A9L0T053 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9796:TRPV5 ^@ http://purl.uniprot.org/uniprot/A0A5F5PWY0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100063748 ^@ http://purl.uniprot.org/uniprot/F7DV74 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NDUFB3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RGU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:PPP6R3 ^@ http://purl.uniprot.org/uniprot/A9CS55 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9796:CARMIL1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PXL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9796:ARPC3 ^@ http://purl.uniprot.org/uniprot/K9K466 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/9796:LOC100052508 ^@ http://purl.uniprot.org/uniprot/F6T6A5 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/9796:CCNG1 ^@ http://purl.uniprot.org/uniprot/F7A3B1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9796:KCNJ16 ^@ http://purl.uniprot.org/uniprot/F6W519 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9796:ADAMTS20 ^@ http://purl.uniprot.org/uniprot/F6PZV0 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9796:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T0N0 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9796:LOC100069113 ^@ http://purl.uniprot.org/uniprot/F7D0X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100065342 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWU4|||http://purl.uniprot.org/uniprot/A0A5F5PGH0|||http://purl.uniprot.org/uniprot/A0A9L0R9T8|||http://purl.uniprot.org/uniprot/A0A9L0S8N0|||http://purl.uniprot.org/uniprot/F6Z5R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9796:LOC100070453 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GVM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DCTN5 ^@ http://purl.uniprot.org/uniprot/A0A9R1SNT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/9796:LOC100053653 ^@ http://purl.uniprot.org/uniprot/A0A5F5PJ61 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9796:LOC100051498 ^@ http://purl.uniprot.org/uniprot/F7DRB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:EQMCE1 ^@ http://purl.uniprot.org/uniprot/Q0R0B5 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:HSF4 ^@ http://purl.uniprot.org/uniprot/A0A9L0RN73|||http://purl.uniprot.org/uniprot/A0A9L0TCS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9796:SEC16A ^@ http://purl.uniprot.org/uniprot/A0A3Q2HY91|||http://purl.uniprot.org/uniprot/F7E1L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/9796:CMC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T6L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9796:TIMP1 ^@ http://purl.uniprot.org/uniprot/O02722 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1 (By similarity).|||Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).|||N-glycosylated.|||Secreted|||The activity of TIMP1 is dependent on the presence of disulfide bonds. http://togogenome.org/gene/9796:ZC3H12B ^@ http://purl.uniprot.org/uniprot/A0A9L0R3L7 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9796:FABP1 ^@ http://purl.uniprot.org/uniprot/F6UL59 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/9796:CASC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T9N0 ^@ Similarity ^@ Belongs to the DNAI7 family. http://togogenome.org/gene/9796:TIRAP ^@ http://purl.uniprot.org/uniprot/A0A9L0R964 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.|||Cell membrane|||Cytoplasm|||Homodimer.|||Membrane http://togogenome.org/gene/9796:SLC7A1 ^@ http://purl.uniprot.org/uniprot/F6TT99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:ACYP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RXZ8 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/9796:NCAPH ^@ http://purl.uniprot.org/uniprot/A0A3Q2HVC8|||http://purl.uniprot.org/uniprot/A0A9L0SH77|||http://purl.uniprot.org/uniprot/A0A9L0SK08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/9796:SLC12A1 ^@ http://purl.uniprot.org/uniprot/A0A5K1V901|||http://purl.uniprot.org/uniprot/F6WDU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9796:PMS1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PYI3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9796:UFD1 ^@ http://purl.uniprot.org/uniprot/H9GZW4 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/9796:LOC100072089 ^@ http://purl.uniprot.org/uniprot/F7B4J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:UMOD ^@ http://purl.uniprot.org/uniprot/F7BN45 ^@ Caution|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||cilium membrane http://togogenome.org/gene/9796:FUT10 ^@ http://purl.uniprot.org/uniprot/F7DBI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9796:FAM207A ^@ http://purl.uniprot.org/uniprot/A0A9L0R758 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLX9 family.|||nucleolus http://togogenome.org/gene/9796:SUPT16H ^@ http://purl.uniprot.org/uniprot/F6WKK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/9796:DQA ^@ http://purl.uniprot.org/uniprot/K9MCE6|||http://purl.uniprot.org/uniprot/K9MD88|||http://purl.uniprot.org/uniprot/Q30457 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9796:SLC52A2 ^@ http://purl.uniprot.org/uniprot/F6UD01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9796:RNF157 ^@ http://purl.uniprot.org/uniprot/A0A9L0S4B2|||http://purl.uniprot.org/uniprot/A0A9L0SK32 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/9796:TAP2 ^@ http://purl.uniprot.org/uniprot/F7DH87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9796:HNRNPC ^@ http://purl.uniprot.org/uniprot/A0A3Q2I630|||http://purl.uniprot.org/uniprot/F6SNV2 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9796:AGTR1 ^@ http://purl.uniprot.org/uniprot/F7D1N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/9796:IL37 ^@ http://purl.uniprot.org/uniprot/A0A5F5PKJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9796:TGFB2 ^@ http://purl.uniprot.org/uniprot/F6WJJ3|||http://purl.uniprot.org/uniprot/F6YX31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9796:WNT10B ^@ http://purl.uniprot.org/uniprot/A0A9L0SCU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9796:SLC25A37 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GS60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:RARG ^@ http://purl.uniprot.org/uniprot/A0A9L0RV81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9796:IYD ^@ http://purl.uniprot.org/uniprot/F7AW63 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9796:PPIL3 ^@ http://purl.uniprot.org/uniprot/K9K2X2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9796:FGF7 ^@ http://purl.uniprot.org/uniprot/F6TLF7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:GPR39 ^@ http://purl.uniprot.org/uniprot/A0A9L0TA06 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:MRPL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SFR3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9796:ADD2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RFJ3 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9796:BECN1 ^@ http://purl.uniprot.org/uniprot/F7AMW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9796:DDX58 ^@ http://purl.uniprot.org/uniprot/A0A9L0RG50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9796:SUFU ^@ http://purl.uniprot.org/uniprot/A0A9L0SY12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).|||Nucleus http://togogenome.org/gene/9796:PGM1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R332 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9796:CFAP97D1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SVE0 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9796:LOC100062521 ^@ http://purl.uniprot.org/uniprot/F6ULN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:CLIC5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I8W6|||http://purl.uniprot.org/uniprot/A0A5F5PJ72 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9796:CEPT1 ^@ http://purl.uniprot.org/uniprot/K9K289|||http://purl.uniprot.org/uniprot/L7MS36 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9796:MMP3 ^@ http://purl.uniprot.org/uniprot/Q28397 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Binds 4 Ca(2+) ions per subunit.|||Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Acts also intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities.|||The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|||extracellular matrix http://togogenome.org/gene/9796:DSE ^@ http://purl.uniprot.org/uniprot/F6TYR9 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9796:EMP2 ^@ http://purl.uniprot.org/uniprot/F6YYQ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/9796:YWHAE ^@ http://purl.uniprot.org/uniprot/A0A5F5PYF1 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9796:LOC100065543 ^@ http://purl.uniprot.org/uniprot/F6Z3A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9796:ASB8 ^@ http://purl.uniprot.org/uniprot/F6YTT0 ^@ Function ^@ May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9796:LOC100060539 ^@ http://purl.uniprot.org/uniprot/F7BTW7 ^@ Function|||Subcellular Location Annotation ^@ Acts as a chemoattractant for neutrophils in chronic inflammation.|||C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.|||Secreted http://togogenome.org/gene/9796:LOC100066863 ^@ http://purl.uniprot.org/uniprot/F6T538 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TLL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TH98 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:VDAC3 ^@ http://purl.uniprot.org/uniprot/K9K267 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9796:HK2 ^@ http://purl.uniprot.org/uniprot/A2PYL6 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hexokinase family.|||Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.|||Hexokinase activity is specifically inhibited by 2,6-disubstituted glucosamines.|||Mitochondrion outer membrane|||Monomer (By similarity). Interacts with TIGAR; the interaction increases hexokinase activity in a hypoxia- and HIF1A-dependent manner (By similarity).|||The N- and C-terminal halves of the protein contain a hexokinase domain. In contrast to hexokinase-1 and -3 (HK1 and HK3, respectively), both hexokinase domains display catalytic activity. The region connecting the two hexokinase domains is required for the catalytic activity of the N-terminal hexokinase domain. The N-terminal half regulates stability of the whole enzyme.|||cytosol http://togogenome.org/gene/9796:ASIC2 ^@ http://purl.uniprot.org/uniprot/E1A462 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:FST ^@ http://purl.uniprot.org/uniprot/O62650 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).|||Monomer.|||Secreted http://togogenome.org/gene/9796:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A5F5PGV6|||http://purl.uniprot.org/uniprot/A0A5F5PP35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9796:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A5F5PNZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/9796:AQP2 ^@ http://purl.uniprot.org/uniprot/F6YNH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:KRT20 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I3K2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:TP63 ^@ http://purl.uniprot.org/uniprot/A0A5F5PP49 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Mitochondrion matrix|||Nucleus|||PML body|||centrosome http://togogenome.org/gene/9796:NAXD ^@ http://purl.uniprot.org/uniprot/F6RDB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Mitochondrion http://togogenome.org/gene/9796:PIAS3 ^@ http://purl.uniprot.org/uniprot/F6RAQ9 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/9796:GCLC ^@ http://purl.uniprot.org/uniprot/A0A9L0RP17 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/9796:LOC100061233 ^@ http://purl.uniprot.org/uniprot/F6T2U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SLC25A53 ^@ http://purl.uniprot.org/uniprot/A0A9L0T168 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:MUL1 ^@ http://purl.uniprot.org/uniprot/F6TM98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:GDF2 ^@ http://purl.uniprot.org/uniprot/F6RLP6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9796:CA5B ^@ http://purl.uniprot.org/uniprot/A0A3Q2LE53 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9796:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I101 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:LOC102149028 ^@ http://purl.uniprot.org/uniprot/A0A9L0SLL6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:ANKS3 ^@ http://purl.uniprot.org/uniprot/F7BQ25 ^@ Function ^@ Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9796:EXOSC2 ^@ http://purl.uniprot.org/uniprot/F6V445 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9796:DBX1 ^@ http://purl.uniprot.org/uniprot/F7D891 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TRIM56 ^@ http://purl.uniprot.org/uniprot/F6UH74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9796:CA10 ^@ http://purl.uniprot.org/uniprot/F6R9S6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9796:GALNT1 ^@ http://purl.uniprot.org/uniprot/F7BR14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:IL12A ^@ http://purl.uniprot.org/uniprot/F6SRN5|||http://purl.uniprot.org/uniprot/Q9XSQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.|||Secreted http://togogenome.org/gene/9796:LOC100067175 ^@ http://purl.uniprot.org/uniprot/F7CUE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DDAH2 ^@ http://purl.uniprot.org/uniprot/F6TY61 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9796:LOC100067873 ^@ http://purl.uniprot.org/uniprot/F7BS24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100054063 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KPN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MRPL19 ^@ http://purl.uniprot.org/uniprot/F6ZUG4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/9796:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A9L0R8H1|||http://purl.uniprot.org/uniprot/A0A9L0T9P5 ^@ Similarity ^@ Belongs to the intercrine alpha (chemokine CxC) family. http://togogenome.org/gene/9796:LOC100068286 ^@ http://purl.uniprot.org/uniprot/F6UPL1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SNCG ^@ http://purl.uniprot.org/uniprot/A0A9L0RMF5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.|||spindle http://togogenome.org/gene/9796:FAM96A ^@ http://purl.uniprot.org/uniprot/A5YBL9 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9796:PDYN ^@ http://purl.uniprot.org/uniprot/F7C032 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opioid activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9796:NELFE ^@ http://purl.uniprot.org/uniprot/A0A5F5PTX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/9796:FOLR2 ^@ http://purl.uniprot.org/uniprot/F7A0H6 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9796:IRF6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HQB9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PEX14 ^@ http://purl.uniprot.org/uniprot/A0A9L0R688 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.|||Peroxisome membrane http://togogenome.org/gene/9796:TIMM10 ^@ http://purl.uniprot.org/uniprot/F6RDH9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9796:F9 ^@ http://purl.uniprot.org/uniprot/F6RFT9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:MYH2 ^@ http://purl.uniprot.org/uniprot/Q8MJV1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).|||Muscle contraction. Required for cytoskeleton organization (By similarity).|||Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with GCSAM.|||Represents a conventional myosin. This protein should not be confused with the unconventional myosin-2 (MYO2).|||The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.|||myofibril http://togogenome.org/gene/9796:CHRDL1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HVC3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:LOC100071402 ^@ http://purl.uniprot.org/uniprot/A0A9L0T382 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TMEM91 ^@ http://purl.uniprot.org/uniprot/F6XZL6 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9796:AMIGO1 ^@ http://purl.uniprot.org/uniprot/F6X0F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9796:MYT1 ^@ http://purl.uniprot.org/uniprot/F7BFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/9796:APOL6 ^@ http://purl.uniprot.org/uniprot/A0A9L0T3Q9 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9796:SLFN5 ^@ http://purl.uniprot.org/uniprot/A0A9L0S6I5 ^@ Similarity ^@ Belongs to the Schlafen family. Subgroup III subfamily. http://togogenome.org/gene/9796:CAV2 ^@ http://purl.uniprot.org/uniprot/Q2QLB1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).|||Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).|||Nucleus|||Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).|||caveola http://togogenome.org/gene/9796:DBH ^@ http://purl.uniprot.org/uniprot/Q9XTA0 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family.|||Binds 2 copper ions per subunit.|||Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.|||Detected in adrenal medulla chromaffin cells.|||Homotetramer; composed of two disulfide-linked dimers.|||N-glycosylated.|||Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form.|||Secreted|||chromaffin granule lumen|||chromaffin granule membrane|||secretory vesicle lumen|||secretory vesicle membrane http://togogenome.org/gene/9796:TMEM231 ^@ http://purl.uniprot.org/uniprot/F6VPK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/9796:NME7 ^@ http://purl.uniprot.org/uniprot/K9K275 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9796:NMNAT1 ^@ http://purl.uniprot.org/uniprot/K9K4E5 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9796:HS3ST3B1 ^@ http://purl.uniprot.org/uniprot/F6SM40 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:PRPF4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HR67|||http://purl.uniprot.org/uniprot/F7CKR6 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9796:IGF2R ^@ http://purl.uniprot.org/uniprot/F6VWA8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:CCL2 ^@ http://purl.uniprot.org/uniprot/B1AB87|||http://purl.uniprot.org/uniprot/Q9TTQ3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).|||Belongs to the intercrine beta (chemokine CC) family.|||Monomer or homodimer; in equilibrium. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Interacts with TNFAIP6 (via Link domain).|||N-Glycosylated.|||Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity).|||Secreted http://togogenome.org/gene/9796:PICALM ^@ http://purl.uniprot.org/uniprot/A0A3Q2H6K4|||http://purl.uniprot.org/uniprot/A0A3Q2I929|||http://purl.uniprot.org/uniprot/F7D8Z8 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/9796:LOC100060483 ^@ http://purl.uniprot.org/uniprot/A0A5F5PXD2|||http://purl.uniprot.org/uniprot/F6QGE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. http://togogenome.org/gene/9796:TNFSF13 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HZM9|||http://purl.uniprot.org/uniprot/F2VR37 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9796:LOC100051878 ^@ http://purl.uniprot.org/uniprot/A0A9L0TQM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:FAM198B ^@ http://purl.uniprot.org/uniprot/F6WNX8 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9796:AFP ^@ http://purl.uniprot.org/uniprot/P49066 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the ALB/AFP/VDB family.|||Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.|||Dimeric and trimeric forms have been found in addition to the monomeric form.|||Plasma.|||Secreted|||Sulfated. http://togogenome.org/gene/9796:KYNU ^@ http://purl.uniprot.org/uniprot/A0A3Q2KVR2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ZNF449 ^@ http://purl.uniprot.org/uniprot/F6YM96 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TMEM181 ^@ http://purl.uniprot.org/uniprot/A0A9L0S357 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100072408 ^@ http://purl.uniprot.org/uniprot/F7D758 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC106783179 ^@ http://purl.uniprot.org/uniprot/A0A9L0TP51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ABCC1 ^@ http://purl.uniprot.org/uniprot/Q0NXS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:GFRA2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I6F1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. http://togogenome.org/gene/9796:SLC26A1 ^@ http://purl.uniprot.org/uniprot/F6XKP3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate. http://togogenome.org/gene/9796:NR0B1 ^@ http://purl.uniprot.org/uniprot/F6RS99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus|||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. http://togogenome.org/gene/9796:LOC106782245 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HEM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:STOM ^@ http://purl.uniprot.org/uniprot/F6RA08 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9796:LOC100068248 ^@ http://purl.uniprot.org/uniprot/F6UPV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DNAJC18 ^@ http://purl.uniprot.org/uniprot/A0A9L0SRG9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:CLDN17 ^@ http://purl.uniprot.org/uniprot/F6VLZ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:APOM ^@ http://purl.uniprot.org/uniprot/A0A9L0SLS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/9796:TF ^@ http://purl.uniprot.org/uniprot/P27425 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the transferrin family.|||Expressed by the liver and secreted in plasma.|||Monomer.|||Secreted|||Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. http://togogenome.org/gene/9796:TAAR2 ^@ http://purl.uniprot.org/uniprot/F7B625 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:IQCG ^@ http://purl.uniprot.org/uniprot/A0A9L0QWM3|||http://purl.uniprot.org/uniprot/A0A9L0RDN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC9 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/9796:PICK1 ^@ http://purl.uniprot.org/uniprot/F7DB33 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.|||cytoskeleton|||perinuclear region|||synaptosome http://togogenome.org/gene/9796:LOC100058863 ^@ http://purl.uniprot.org/uniprot/F7B5F1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PUS7L ^@ http://purl.uniprot.org/uniprot/A0A3Q2KJH1 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/9796:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LRM0 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/9796:UTP11 ^@ http://purl.uniprot.org/uniprot/F6WMD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9796:RASGRP4 ^@ http://purl.uniprot.org/uniprot/F6YVT0 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9796:LOC100064551 ^@ http://purl.uniprot.org/uniprot/A0A5F5PIW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:GUCA2A ^@ http://purl.uniprot.org/uniprot/F7D0S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9796:SLC16A9 ^@ http://purl.uniprot.org/uniprot/F7C4J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:UCP3 ^@ http://purl.uniprot.org/uniprot/F6Y401 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:PSMA2 ^@ http://purl.uniprot.org/uniprot/F6TCI4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9796:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/F6XSB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9796:CCDC58 ^@ http://purl.uniprot.org/uniprot/A0A9L0RAZ8 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9796:CASQ2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RGY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9796:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HCE6 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9796:NAA11 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HRD2 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9796:AURKB ^@ http://purl.uniprot.org/uniprot/F7DPL7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/9796:GAD1 ^@ http://purl.uniprot.org/uniprot/F6ZIC0 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9796:DDX21 ^@ http://purl.uniprot.org/uniprot/A0A9L0S9Q4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9796:SSTR1 ^@ http://purl.uniprot.org/uniprot/F6QWD7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:KEF40_p10 ^@ http://purl.uniprot.org/uniprot/A5JYB7|||http://purl.uniprot.org/uniprot/P48660 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Binds a dinuclear copper A center per subunit.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:LOC106783320 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HUB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:KEF40_p13 ^@ http://purl.uniprot.org/uniprot/P48652|||http://purl.uniprot.org/uniprot/Q6J6X5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:MRPS10 ^@ http://purl.uniprot.org/uniprot/A0A9L0SYY0|||http://purl.uniprot.org/uniprot/F7D150 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/9796:SKA1 ^@ http://purl.uniprot.org/uniprot/F6UK20 ^@ Similarity ^@ Belongs to the SKA1 family. http://togogenome.org/gene/9796:SLC9A2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H2A8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/9796:PMP22 ^@ http://purl.uniprot.org/uniprot/Q6WL85 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Might be involved in growth regulation, and in myelinization in the peripheral nervous system.|||Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation. http://togogenome.org/gene/9796:RPRD1B ^@ http://purl.uniprot.org/uniprot/A0A9L0TN20 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9796:CDC26 ^@ http://purl.uniprot.org/uniprot/A0A9L0SEY4 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9796:LOC100057977 ^@ http://purl.uniprot.org/uniprot/F7CXV4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A9L0SCG1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:TLR3 ^@ http://purl.uniprot.org/uniprot/A0ENH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9796:SLC25A29 ^@ http://purl.uniprot.org/uniprot/A0A5F5PFY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:SF3B5 ^@ http://purl.uniprot.org/uniprot/F6QIH9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/9796:TM4SF1 ^@ http://purl.uniprot.org/uniprot/F7A891 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9796:HPGD ^@ http://purl.uniprot.org/uniprot/A2T0Y1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:SEC24C ^@ http://purl.uniprot.org/uniprot/F6XTW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9796:COPZ1 ^@ http://purl.uniprot.org/uniprot/K9K447 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9796:EPHA7 ^@ http://purl.uniprot.org/uniprot/F6Z105 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:SRFBP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R0H2 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/9796:LOC100057625 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GSB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TMEM229B ^@ http://purl.uniprot.org/uniprot/A0A9L0QZ66|||http://purl.uniprot.org/uniprot/A0A9L0RUU7|||http://purl.uniprot.org/uniprot/A0A9L0T536|||http://purl.uniprot.org/uniprot/A0A9L0TEE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/9796:CNIH4 ^@ http://purl.uniprot.org/uniprot/A0A9R1SB27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9796:GPRIN2 ^@ http://purl.uniprot.org/uniprot/F7AZG0 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9796:CLUL1 ^@ http://purl.uniprot.org/uniprot/F6ZBU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Secreted http://togogenome.org/gene/9796:SNUPN ^@ http://purl.uniprot.org/uniprot/A0A9R1SQR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snurportin family.|||Cytoplasm|||Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.|||Nucleus http://togogenome.org/gene/9796:FAM241B ^@ http://purl.uniprot.org/uniprot/A0A9L0TQU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9796:ERH ^@ http://purl.uniprot.org/uniprot/A0A9L0TQ11 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/9796:ARSG ^@ http://purl.uniprot.org/uniprot/F6UND9 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9796:PIGL ^@ http://purl.uniprot.org/uniprot/A0A5F5PJJ4 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/9796:CAMK2D ^@ http://purl.uniprot.org/uniprot/A0A3Q2HPA6|||http://purl.uniprot.org/uniprot/A0A3Q2I0K4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9796:SURF6 ^@ http://purl.uniprot.org/uniprot/F6T8R5 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/9796:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/Q9GKX8 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cell membrane|||Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.|||Cytoplasm|||Dynein axonemal particle|||ISGylated.|||In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.|||Melanosome|||Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.|||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10.|||Monomer. Homodimer (By similarity). Forms a complex with CDK6 and CDC37. Interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity). Interacts with CHORDC1 (By similarity). Interacts with DNAJC7. Interacts with FKBP4. May interact with NWD1. Interacts with SGTA. Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with STUB1 and SMAD3. Interacts with XPO1 and AHSA1. Interacts with BIRC2. Interacts with KCNQ4; promotes cell surface expression of KCNQ4. Interacts with BIRC2; prevents auto-ubiquitination and degradation of its client protein BIRC2. Interacts with NOS3. Interacts with AHR; interaction is inhibited by HSP90AB1 phosphorylation on Ser-226 and Ser-255. Interacts with STIP1 and CDC37; upon SMYD2-dependent methylation. Interacts with JAK2 and PRKCE; promotes functional activation in a heat shock-dependent manner. Interacts with HSP90AA1; interaction is constitutive. HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation. Interacts with CDC25A; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression. Interacts with TP53 (via DNA binding domain); suppresses TP53 aggregation and prevents from irreversible thermal inactivation. Interacts with TGFB1 processed form (LAP); inhibits latent TGFB1 activation (By similarity). Interacts with TRIM8; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with TTC4 (via TPR repeats) (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation into the ERGIC (By similarity).|||Nucleus|||Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide. Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.|||S-nitrosylated; negatively regulates the ATPase activity.|||Secreted|||The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.|||Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro). http://togogenome.org/gene/9796:TAAR3 ^@ http://purl.uniprot.org/uniprot/F7B6M3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:LOC102148649 ^@ http://purl.uniprot.org/uniprot/A0A9L0THA3 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9796:FKBP6 ^@ http://purl.uniprot.org/uniprot/F6PHZ6 ^@ Caution|||Disease Annotation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity.|||Belongs to the FKBP6 family.|||Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).|||Defects in FKBP6 may be a cause of stallion sterility due to defects in acrosomal reaction. Disease susceptibility is associated with variants affecting the gene represented in this entry (PubMed:23284302).|||Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity. Interacts (via TPR repeats) with HSP90 (By similarity).|||Nucleus|||Specifically expressed in testis and sperm.|||cytosol http://togogenome.org/gene/9796:HCN3 ^@ http://purl.uniprot.org/uniprot/F7D898 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:FAM183A ^@ http://purl.uniprot.org/uniprot/A0A5F5PFP8 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/9796:MPEG1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T1V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPEG1 family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/9796:LOC100147364 ^@ http://purl.uniprot.org/uniprot/F7A6J6 ^@ Function|||Similarity ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. http://togogenome.org/gene/9796:PLXNB3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I9B5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:GUCY2F ^@ http://purl.uniprot.org/uniprot/F6ZZC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/9796:C1D ^@ http://purl.uniprot.org/uniprot/A0A9L0R303|||http://purl.uniprot.org/uniprot/F6VRU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/9796:GPR87 ^@ http://purl.uniprot.org/uniprot/F7BQM6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:LOC100630878 ^@ http://purl.uniprot.org/uniprot/F7CYE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100053695 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HBF8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:CD4 ^@ http://purl.uniprot.org/uniprot/A0A9L0TGW4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9796:NFYA ^@ http://purl.uniprot.org/uniprot/F6UF83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9796:BCHE ^@ http://purl.uniprot.org/uniprot/Q9N1N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/9796:CXCR3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T1D1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/9796:LOC100056890 ^@ http://purl.uniprot.org/uniprot/A0A9L0R357 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ELL3 ^@ http://purl.uniprot.org/uniprot/A0A9L0R9R5|||http://purl.uniprot.org/uniprot/A0A9L0RFP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9796:EDN2 ^@ http://purl.uniprot.org/uniprot/Q867D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Endothelins are endothelium-derived vasoconstrictor peptides.|||Secreted http://togogenome.org/gene/9796:GLYCTK ^@ http://purl.uniprot.org/uniprot/F6QH72 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9796:SLC4A1 ^@ http://purl.uniprot.org/uniprot/Q2Z1P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PPIA ^@ http://purl.uniprot.org/uniprot/F6X6A6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9796:ARL1 ^@ http://purl.uniprot.org/uniprot/K9K2X5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9796:BLOC1S2 ^@ http://purl.uniprot.org/uniprot/A0A9L0T5Q9 ^@ Similarity ^@ Belongs to the BLOC1S2 family. http://togogenome.org/gene/9796:CHRNA6 ^@ http://purl.uniprot.org/uniprot/F7DKD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:ITGB7 ^@ http://purl.uniprot.org/uniprot/F7AKH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||Recycling endosome|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9796:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/K9KB55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9796:CCL28 ^@ http://purl.uniprot.org/uniprot/F6VWX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9796:RNGTT ^@ http://purl.uniprot.org/uniprot/F6PHA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/9796:VCAM1 ^@ http://purl.uniprot.org/uniprot/A7LP08 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9796:GAD2 ^@ http://purl.uniprot.org/uniprot/F7D4X1 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9796:STEAP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RI04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9796:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A9L0T9W9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/9796:PAPPA2 ^@ http://purl.uniprot.org/uniprot/F6R5T7 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:BRPF1 ^@ http://purl.uniprot.org/uniprot/F6U463 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:SLC4A2 ^@ http://purl.uniprot.org/uniprot/Q6SJP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (By similarity). Plays an important role in osteoclast differentiation and function (By similarity). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell response (By similarity). http://togogenome.org/gene/9796:LOC100067104 ^@ http://purl.uniprot.org/uniprot/F7C4A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100064454 ^@ http://purl.uniprot.org/uniprot/F6RMT8 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:PLCG2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HD48 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9796:MB ^@ http://purl.uniprot.org/uniprot/P68082 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9796:NDRG2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PPS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm http://togogenome.org/gene/9796:MMP1 ^@ http://purl.uniprot.org/uniprot/Q9XSZ5 ^@ Activity Regulation|||Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Binds 4 Ca(2+) ions per subunit.|||Can be activated without removal of the activation peptide.|||Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X.|||The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|||Tyrosine phosphorylated in platelets by PKDCC/VLK.|||extracellular matrix http://togogenome.org/gene/9796:AGL ^@ http://purl.uniprot.org/uniprot/A8BQB4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Monomer. Interacts with NHLRC1/malin (By similarity).|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.|||Ubiquitinated.|||Ubiquitous. Expressed in striated skeletal muscle, heart, liver, spleen, skin, spinal cord, lung, kidney and testicle. http://togogenome.org/gene/9796:SAA ^@ http://purl.uniprot.org/uniprot/Q9N0Y1 ^@ Function|||Similarity ^@ Belongs to the SAA family.|||Major acute phase reactant. Apolipoprotein of the HDL complex. http://togogenome.org/gene/9796:PCNA ^@ http://purl.uniprot.org/uniprot/F6R950 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/9796:AGK ^@ http://purl.uniprot.org/uniprot/A0A9L0SY85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9796:FAIM2 ^@ http://purl.uniprot.org/uniprot/F6Y5Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9796:GJA4 ^@ http://purl.uniprot.org/uniprot/F7C8J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:KIF1BP ^@ http://purl.uniprot.org/uniprot/F7D3N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/9796:UCN3 ^@ http://purl.uniprot.org/uniprot/F6VA03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/9796:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/F6QG54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9796:ARNTL ^@ http://purl.uniprot.org/uniprot/A0MLS5 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Acetylated on Lys-538 by CLOCK during the repression phase of the circadian cycle. Acetylation facilitates recruitment of CRY1 protein and initiates the repression phase of the circadian cycle. Acetylated at Lys-538 by KAT5 during the activation phase of the cycle, leading to recruitment of the positive transcription elongation factor b (P-TEFb) and BRD4, followed by productive elongation of circadian transcripts. Deacetylated by SIRT1, which may result in decreased protein stability.|||Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (By similarity). Forms a heterodimer with CLOCK (By similarity). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and BMAL1 (By similarity). Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian manner (By similarity). Interacts with NPAS2 (By similarity). Interacts with EZH2 (By similarity). Interacts with SUMO3 (By similarity). Interacts with SIRT1 (By similarity). Interacts with AHR (By similarity). Interacts with ID1, ID2 and ID3 (By similarity). Interacts with DDX4 (By similarity). Interacts with OGT (By similarity). Interacts with EED and SUZ12 (By similarity). Interacts with MTA1 (By similarity). Interacts with CIART (By similarity). Interacts with HSP90 (By similarity). Interacts with KAT2B and EP300 (By similarity). Interacts with BHLHE40/DEC1 and BHLHE41/DEC2 (By similarity). Interacts with RELB and the interaction is enhanced in the presence of CLOCK (By similarity). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (By similarity). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation (By similarity). Interaction of the CLOCK-BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (By similarity). The CLOCK-BMAL1 heterodimer interacts with GSK3B (By similarity). Interacts with KDM5A (By similarity). Interacts with KMT2A; in a circadian manner (By similarity). Interacts with UBE3A (By similarity). Interacts with PRKCG (By similarity). Interacts with MAGEL2 (By similarity). Interacts with NCOA2 (By similarity). Interacts with THRAP3 (By similarity). The CLOCK-BMAL1 heterodimer interacts with PASD1 (By similarity). Interacts with PASD1 (By similarity). Interacts with USP9X (By similarity). Interacts with PIWIL2 (via PIWI domain) (By similarity). Interacts with HDAC3 (By similarity). Interacts with HNF4A (By similarity).|||Cytoplasm|||Nucleus|||O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2 (By similarity).|||PML body|||Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-90 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry. Dephosphorylation at Ser-78 is important for dimerization with CLOCK and transcriptional activity.|||Sumoylated on Lys-259 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-BMAL1 heterodimer (By similarity).|||Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence. CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3'. The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3'. Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1. Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity).|||Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP9X.|||Undergoes lysosome-mediated degradation in a time-dependent manner in the liver. http://togogenome.org/gene/9796:SSTR5 ^@ http://purl.uniprot.org/uniprot/F6RAW3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:FABP9 ^@ http://purl.uniprot.org/uniprot/A0A9L0SYH5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9796:CAPN5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H6E7 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9796:ARL11 ^@ http://purl.uniprot.org/uniprot/A0A5F5PZ07 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9796:PTPN14 ^@ http://purl.uniprot.org/uniprot/F6VJ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/9796:LOC100063645 ^@ http://purl.uniprot.org/uniprot/F6XJ24 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9796:NADSYN1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S2F4 ^@ Similarity|||Subunit ^@ Homohexamer.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/9796:LOC100052658 ^@ http://purl.uniprot.org/uniprot/A0A7R8C3U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:TDO2 ^@ http://purl.uniprot.org/uniprot/F7CRD2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LPAR4 ^@ http://purl.uniprot.org/uniprot/A0A5F5PVC0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:TNF ^@ http://purl.uniprot.org/uniprot/B1AB92|||http://purl.uniprot.org/uniprot/P29553 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).|||Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.|||Homotrimer. Interacts with SPPL2B (By similarity).|||Homotrimer. Interacts with SPPL2B.|||Membrane|||O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.|||Secreted|||The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).|||The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).|||The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.|||The soluble form is demyristoylated by SIRT6, promoting its secretion. http://togogenome.org/gene/9796:SLC2A4 ^@ http://purl.uniprot.org/uniprot/Q8MJ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Endomembrane system|||Membrane|||perinuclear region http://togogenome.org/gene/9796:CANT1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IF61 ^@ Similarity ^@ Belongs to the apyrase family. http://togogenome.org/gene/9796:LIN7A ^@ http://purl.uniprot.org/uniprot/F6YJ71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9796:LIG3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IKK5 ^@ Similarity ^@ Belongs to the ATP-dependent DNA ligase family. http://togogenome.org/gene/9796:NME6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RAD7 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9796:HINT1 ^@ http://purl.uniprot.org/uniprot/K9KBY4 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9796:MMP7 ^@ http://purl.uniprot.org/uniprot/A0A9L0T9Q1 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/9796:VAMP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T2D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9796:ADGRF5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RKI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/9796:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HL06|||http://purl.uniprot.org/uniprot/A0A3Q2IBF6|||http://purl.uniprot.org/uniprot/A0A3Q2ICI8 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9796:CCL26 ^@ http://purl.uniprot.org/uniprot/F6ZD18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9796:LOC100146423 ^@ http://purl.uniprot.org/uniprot/M1ZMN7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9796:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/F6ZMH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9796:MED4 ^@ http://purl.uniprot.org/uniprot/F6YFK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9796:ACSM4 ^@ http://purl.uniprot.org/uniprot/F6XXC2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9796:LIMS1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S8S1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9796:LOC100073305 ^@ http://purl.uniprot.org/uniprot/F6TCC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9796:ERBB4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LCD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9796:BUD31 ^@ http://purl.uniprot.org/uniprot/A0A9L0T4B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9796:ST8SIA4 ^@ http://purl.uniprot.org/uniprot/F7AEM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9796:LPAR6 ^@ http://purl.uniprot.org/uniprot/F6SPW5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:TMTC4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KNS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9796:BEND6 ^@ http://purl.uniprot.org/uniprot/A0A9L0SGF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100056577 ^@ http://purl.uniprot.org/uniprot/F6QN61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:XCL1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IDW7 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family.|||Belongs to the intercrine gamma family. http://togogenome.org/gene/9796:PSMA3 ^@ http://purl.uniprot.org/uniprot/L7MS06 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9796:RGS2 ^@ http://purl.uniprot.org/uniprot/B7X6D7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||nucleolus http://togogenome.org/gene/9796:LPXN ^@ http://purl.uniprot.org/uniprot/A0A9L0RPQ6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||Cell membrane|||Cytoplasm|||Nucleus|||The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.|||Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).|||focal adhesion|||perinuclear region|||podosome http://togogenome.org/gene/9796:SPATA6L ^@ http://purl.uniprot.org/uniprot/F6WKS4 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/9796:LRRC8D ^@ http://purl.uniprot.org/uniprot/F6Z951 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:NUS1 ^@ http://purl.uniprot.org/uniprot/F7DQU7 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9796:MRPL47 ^@ http://purl.uniprot.org/uniprot/F7A5V3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9796:STARD9 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H095|||http://purl.uniprot.org/uniprot/A0A9L0S318 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9796:CHRNG ^@ http://purl.uniprot.org/uniprot/F7AHA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:HBA2 ^@ http://purl.uniprot.org/uniprot/Q28383 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9796:CALCRL ^@ http://purl.uniprot.org/uniprot/A0A9L0SXF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.|||Membrane|||Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9796:ADAMDEC1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HGK3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:RPGRIP1L ^@ http://purl.uniprot.org/uniprot/A0A5F5PWE0 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/9796:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PXJ9 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9796:PTP4A2 ^@ http://purl.uniprot.org/uniprot/K9K410 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9796:GSG1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I270|||http://purl.uniprot.org/uniprot/A0A9L0RJB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/9796:TAGLN ^@ http://purl.uniprot.org/uniprot/A8J714 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9796:TLR10 ^@ http://purl.uniprot.org/uniprot/F6VHZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9796:CD3D ^@ http://purl.uniprot.org/uniprot/F7CIT2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:ARID5B ^@ http://purl.uniprot.org/uniprot/A0A5F5PMV3 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/9796:NR6A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TIS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9796:ESR2 ^@ http://purl.uniprot.org/uniprot/F6S2G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9796:PLA2G5 ^@ http://purl.uniprot.org/uniprot/A0A9L0T1I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9796:BARHL1 ^@ http://purl.uniprot.org/uniprot/F6W4G4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:GDE1 ^@ http://purl.uniprot.org/uniprot/F6S8V0 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9796:GJC3 ^@ http://purl.uniprot.org/uniprot/F6Z9W1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||gap junction http://togogenome.org/gene/9796:HNF1B ^@ http://purl.uniprot.org/uniprot/F6WBR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/9796:OLFM3 ^@ http://purl.uniprot.org/uniprot/F6Q7Q2 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9796:IGFBP5 ^@ http://purl.uniprot.org/uniprot/F7ALY5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:POU4F2 ^@ http://purl.uniprot.org/uniprot/F6U8H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9796:ATXN1L ^@ http://purl.uniprot.org/uniprot/A0A9L0T841 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/9796:GJB1 ^@ http://purl.uniprot.org/uniprot/A0A654ICR5|||http://purl.uniprot.org/uniprot/Q6WGK6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).|||A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:SPARC ^@ http://purl.uniprot.org/uniprot/B8K2M6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9796:BMP7 ^@ http://purl.uniprot.org/uniprot/E0A9E2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9796:BBS7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HCJ6 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/9796:HTR1E ^@ http://purl.uniprot.org/uniprot/F6YL63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:BIRC3 ^@ http://purl.uniprot.org/uniprot/F6SJV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:CDC37L1 ^@ http://purl.uniprot.org/uniprot/F7DU75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/9796:SPARCL1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q2Q6 ^@ Similarity ^@ Belongs to the SPARC family. http://togogenome.org/gene/9796:CTBP2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H467 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9796:ACTL7B ^@ http://purl.uniprot.org/uniprot/F6RBJ9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:LOC100064358 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:RPL37 ^@ http://purl.uniprot.org/uniprot/A0A5F5PRZ1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9796:FAN1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PLV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/9796:C22H20orf24 ^@ http://purl.uniprot.org/uniprot/A0A9L0RIG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:POU6F1 ^@ http://purl.uniprot.org/uniprot/F6WRV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9796:SLC25A47 ^@ http://purl.uniprot.org/uniprot/A0A9L0TJB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:NKX2-6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L478 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:FUNDC1 ^@ http://purl.uniprot.org/uniprot/F6U1Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9796:NQO1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SR96 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9796:CLDN12 ^@ http://purl.uniprot.org/uniprot/F7B304 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/9796:MYH7 ^@ http://purl.uniprot.org/uniprot/F6YJN7|||http://purl.uniprot.org/uniprot/Q8MJU9 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).|||Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with ECPAS. Interacts (via C-terminus) with LRRC39.|||Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.|||Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).|||The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.|||The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. Four skip residues (Skip1: Thr-1188, Skip2: Glu-1385, Skip3: Glu-1582 and Skip4: Gly-1807) introduce discontinuities in the coiled-coil heptad repeats. The first three skip residues are structurally comparable and induce a unique local relaxation of the coiled-coil superhelical pitch and the fourth skip residue lies within a highly flexible molecular hinge that is necessary for myosin incorporation in the bare zone of sarcomeres.|||myofibril|||sarcomere http://togogenome.org/gene/9796:LOC100050034 ^@ http://purl.uniprot.org/uniprot/A0A9L0RS75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9796:GMPPA ^@ http://purl.uniprot.org/uniprot/F7BEM5 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9796:SMIM19 ^@ http://purl.uniprot.org/uniprot/A0A9L0T144 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/9796:SURF4 ^@ http://purl.uniprot.org/uniprot/A0A9L0T1J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:NMU ^@ http://purl.uniprot.org/uniprot/A0A3Q2HSM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/9796:PCK1 ^@ http://purl.uniprot.org/uniprot/F6ZRM2 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/9796:STARD8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SVR4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:SLC30A7 ^@ http://purl.uniprot.org/uniprot/F6ZXQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9796:LOC100067436 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNF7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:BPNT1 ^@ http://purl.uniprot.org/uniprot/F6UIC2 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9796:GPR12 ^@ http://purl.uniprot.org/uniprot/A0A9L0T1R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:CFL2 ^@ http://purl.uniprot.org/uniprot/F7CT91 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9796:TSPYL5 ^@ http://purl.uniprot.org/uniprot/F6YC53 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9796:PEMT ^@ http://purl.uniprot.org/uniprot/A0A9L0S4F7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9796:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A3Q2IGC7|||http://purl.uniprot.org/uniprot/A0A3Q2L3V8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9796:DCTN6 ^@ http://purl.uniprot.org/uniprot/K9K3S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/9796:NPSR1 ^@ http://purl.uniprot.org/uniprot/F6QT90 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:SENP8 ^@ http://purl.uniprot.org/uniprot/F6YXM4 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9796:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/F6UK47 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:AMER1 ^@ http://purl.uniprot.org/uniprot/F6WVP3 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9796:DNAAF4 ^@ http://purl.uniprot.org/uniprot/A0A5F5PL24|||http://purl.uniprot.org/uniprot/F6ZNG0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Dynein axonemal particle|||neuron projection http://togogenome.org/gene/9796:CAB39L ^@ http://purl.uniprot.org/uniprot/K9K392 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9796:METTL3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RZ65 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9796:NDP ^@ http://purl.uniprot.org/uniprot/F6VGL4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:SFTPA1 ^@ http://purl.uniprot.org/uniprot/Q95L88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SFTPA family.|||In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.|||Oligomeric complex of 6 set of homotrimers.|||Secreted|||extracellular matrix|||surface film http://togogenome.org/gene/9796:GTF2H4 ^@ http://purl.uniprot.org/uniprot/A0A9L0RLX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/9796:HRH4 ^@ http://purl.uniprot.org/uniprot/D6QXZ6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:INHA ^@ http://purl.uniprot.org/uniprot/P55101 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.|||Secreted http://togogenome.org/gene/9796:HSPA1A ^@ http://purl.uniprot.org/uniprot/A0A9L0RZP4 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9796:FOXM1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KSN4|||http://purl.uniprot.org/uniprot/F7BPF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:MIS12 ^@ http://purl.uniprot.org/uniprot/F6UU36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/9796:SLX4 ^@ http://purl.uniprot.org/uniprot/F7CSW5 ^@ Similarity ^@ Belongs to the SLX4 family. http://togogenome.org/gene/9796:HOXB1 ^@ http://purl.uniprot.org/uniprot/F7BMD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9796:GINS4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SZJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9796:DZIP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZ14|||http://purl.uniprot.org/uniprot/A0A3Q2LQU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||cilium basal body http://togogenome.org/gene/9796:LOC100057500 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HX18 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||acrosome inner membrane http://togogenome.org/gene/9796:LOC100056543 ^@ http://purl.uniprot.org/uniprot/A0A9L0RBD9 ^@ Function|||Subcellular Location Annotation ^@ Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:SEPSECS ^@ http://purl.uniprot.org/uniprot/A0A9L0STJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/9796:SEMA3B ^@ http://purl.uniprot.org/uniprot/F7AP03 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SI12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9796:DBR1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HBT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/9796:ANKRD34A ^@ http://purl.uniprot.org/uniprot/F6T9Y5 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9796:LOC100056428 ^@ http://purl.uniprot.org/uniprot/F7C973 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9796:DGKA ^@ http://purl.uniprot.org/uniprot/A0A9L0R7H0 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic diacylglycerol kinase family.|||Monomer. http://togogenome.org/gene/9796:IL17B ^@ http://purl.uniprot.org/uniprot/F6ZF52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9796:TFIP11 ^@ http://purl.uniprot.org/uniprot/F6TXE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/9796:NPY5R ^@ http://purl.uniprot.org/uniprot/F6TWY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. http://togogenome.org/gene/9796:SOD1 ^@ http://purl.uniprot.org/uniprot/D7PPM2|||http://purl.uniprot.org/uniprot/P00443 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Homodimer; non-disulfide-linked (By similarity). Heterodimer with SOD1. The heterodimer CCS:SOD1 interacts with SLC31A1; this heterotrimer is Cu(1+)-mediated and its maintenance is regulated through SOD1 activation (By similarity).|||Nucleus|||Palmitoylation helps nuclear targeting and decreases catalytic activity.|||Succinylation, adjacent to copper catalytic site, probably inhibits activity. Desuccinylation by SIRT5 enhances activity. http://togogenome.org/gene/9796:KAT5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I554|||http://purl.uniprot.org/uniprot/F6UXD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9796:PTGS2 ^@ http://purl.uniprot.org/uniprot/O19183 ^@ Cofactor|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.|||Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection. In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity).|||Endoplasmic reticulum membrane|||Homodimer.|||Microsome membrane|||Nucleus inner membrane|||Nucleus outer membrane|||PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.|||S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.|||The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site. http://togogenome.org/gene/9796:BAAT ^@ http://purl.uniprot.org/uniprot/F6Q5W5 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9796:TRAK1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HNL6|||http://purl.uniprot.org/uniprot/A0A3Q2I5L0|||http://purl.uniprot.org/uniprot/A0A5F5PNM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/9796:GGNBP2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HGL4 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9796:TNP1 ^@ http://purl.uniprot.org/uniprot/F7VJM0 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 1 family.|||Chromosome|||Nucleus|||The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry. http://togogenome.org/gene/9796:CCL1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HK92 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9796:SERPINB5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RW42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family. Ov-serpin subfamily.|||extracellular space http://togogenome.org/gene/9796:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/F7BWP5 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/9796:LOC100067446 ^@ http://purl.uniprot.org/uniprot/F7CAX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9796:SDR9C7 ^@ http://purl.uniprot.org/uniprot/F6ZG36 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TJ81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9796:ENPP3 ^@ http://purl.uniprot.org/uniprot/F7CLE3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:HEXDC ^@ http://purl.uniprot.org/uniprot/A0A9L0R535|||http://purl.uniprot.org/uniprot/F7CT58 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/9796:TACC2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HTI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/9796:PTK6 ^@ http://purl.uniprot.org/uniprot/F6ZIG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:FGF6 ^@ http://purl.uniprot.org/uniprot/A0A9L0SAK8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:TSHB ^@ http://purl.uniprot.org/uniprot/Q28376 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|||Indispensable for the control of thyroid structure and metabolism.|||Secreted http://togogenome.org/gene/9796:ATP5F1C ^@ http://purl.uniprot.org/uniprot/F6SJM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9796:IL23A ^@ http://purl.uniprot.org/uniprot/B1AB86|||http://purl.uniprot.org/uniprot/Q64FU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.|||Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. Interacts with IL23R; this interaction enables recruitment of IL12RB1.|||Secreted http://togogenome.org/gene/9796:MLH1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TRX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/9796:MFSD11 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q3C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9796:RAD50 ^@ http://purl.uniprot.org/uniprot/F7AR56 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/9796:CX3CR1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LEC3|||http://purl.uniprot.org/uniprot/A0A9L0RLE4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.|||Membrane http://togogenome.org/gene/9796:PLAC8 ^@ http://purl.uniprot.org/uniprot/F7D1W3 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9796:SPC25 ^@ http://purl.uniprot.org/uniprot/F6SDF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9796:NMBR ^@ http://purl.uniprot.org/uniprot/F6VCY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PTGDS ^@ http://purl.uniprot.org/uniprot/O97921 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the calycin superfamily. Lipocalin family.|||Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.|||Golgi apparatus|||In the male reproductive system, it is expressed in the testis and epididymis, and is secreted into the seminal fluid.|||Monomer.|||Nucleus membrane|||Rough endoplasmic reticulum|||Secreted|||perinuclear region http://togogenome.org/gene/9796:LPCAT4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SNL8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9796:MEA1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SV21 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/9796:C6 ^@ http://purl.uniprot.org/uniprot/F6YQL3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:CA8 ^@ http://purl.uniprot.org/uniprot/A0A9L0T2Y1 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9796:VIRMA ^@ http://purl.uniprot.org/uniprot/A0A3Q2HG25|||http://purl.uniprot.org/uniprot/F6R0Z7 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/9796:TGIF2LX ^@ http://purl.uniprot.org/uniprot/A0A3Q2GX77 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100055600 ^@ http://purl.uniprot.org/uniprot/F6Y9H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SB51 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9796:SNRPA ^@ http://purl.uniprot.org/uniprot/A0A9L0SV69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM U1 A/B'' family.|||Nucleus http://togogenome.org/gene/9796:NMUR2 ^@ http://purl.uniprot.org/uniprot/F7DC92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9796:SUGP1 ^@ http://purl.uniprot.org/uniprot/F7APL1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:CENPH ^@ http://purl.uniprot.org/uniprot/F6PLT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9796:CNFN ^@ http://purl.uniprot.org/uniprot/F6X292 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9796:MINDY1 ^@ http://purl.uniprot.org/uniprot/F6Y5P3 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9796:BEX5 ^@ http://purl.uniprot.org/uniprot/A0A9L0QZB9 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9796:CD70 ^@ http://purl.uniprot.org/uniprot/F6XHL7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9796:LOC100071974 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HC98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DDX52 ^@ http://purl.uniprot.org/uniprot/A0A9L0R393 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/9796:AMOT ^@ http://purl.uniprot.org/uniprot/F6TAL1 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9796:NAPEPLD ^@ http://purl.uniprot.org/uniprot/A0A9L0RQI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPE-PLD family.|||Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.|||Nucleus envelope http://togogenome.org/gene/9796:RFTN1 ^@ http://purl.uniprot.org/uniprot/F7BMG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:RPL3L ^@ http://purl.uniprot.org/uniprot/F6TCN4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9796:POLR3H ^@ http://purl.uniprot.org/uniprot/A0A9L0TI92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9796:TMEM86B ^@ http://purl.uniprot.org/uniprot/A0A9L0SGW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9796:FUCA1 ^@ http://purl.uniprot.org/uniprot/F6SS69 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9796:GMFG ^@ http://purl.uniprot.org/uniprot/A0A9L0SM79 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9796:OLFML2B ^@ http://purl.uniprot.org/uniprot/F6Z1C0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:EMC3 ^@ http://purl.uniprot.org/uniprot/A0A9L0S9W8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9796:OTX2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SNB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9796:SLC9A5 ^@ http://purl.uniprot.org/uniprot/F6VLD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Membrane|||Recycling endosome membrane http://togogenome.org/gene/9796:HDC ^@ http://purl.uniprot.org/uniprot/F6UI58 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9796:COQ10B ^@ http://purl.uniprot.org/uniprot/F7ADM7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9796:IDO1 ^@ http://purl.uniprot.org/uniprot/F6WI76 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9796:MBLAC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RT54 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9796:PEX5 ^@ http://purl.uniprot.org/uniprot/F7AGZ6 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9796:MRAP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TH43|||http://purl.uniprot.org/uniprot/F7BRV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:LOC100049818 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L811 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:B3GAT1 ^@ http://purl.uniprot.org/uniprot/F6UN48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:GNL2 ^@ http://purl.uniprot.org/uniprot/F6TYL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/9796:GDPD1 ^@ http://purl.uniprot.org/uniprot/F6U0M2 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9796:SLC22A8 ^@ http://purl.uniprot.org/uniprot/F6QUP6 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/9796:SLC16A14 ^@ http://purl.uniprot.org/uniprot/F7A5W5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:YKT6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HFC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9796:FAM110B ^@ http://purl.uniprot.org/uniprot/F6QGA6 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9796:CLEC18B ^@ http://purl.uniprot.org/uniprot/F6Q300 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:TLR2 ^@ http://purl.uniprot.org/uniprot/Q6T752 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).|||Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.|||Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.|||In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.|||Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).|||Membrane|||Membrane raft|||The ATG16L1-binding motif mediates interaction with ATG16L1.|||Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.|||phagosome membrane http://togogenome.org/gene/9796:TAT ^@ http://purl.uniprot.org/uniprot/F6YST0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9796:ALDH7A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R3Y5 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9796:DMRT1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HC67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9796:AURKA ^@ http://purl.uniprot.org/uniprot/A0A9L0T801 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9796:LOC100147174 ^@ http://purl.uniprot.org/uniprot/A0A5F5PQR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:LOC102147968 ^@ http://purl.uniprot.org/uniprot/F6W7Y5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100070528 ^@ http://purl.uniprot.org/uniprot/A0A452GEP5 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9796:PLA2G2C ^@ http://purl.uniprot.org/uniprot/A0A9L0RMR9|||http://purl.uniprot.org/uniprot/A0A9L0SDX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9796:TPMT ^@ http://purl.uniprot.org/uniprot/Q3BCR6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9796:IL18 ^@ http://purl.uniprot.org/uniprot/B1AB85|||http://purl.uniprot.org/uniprot/Q9XSQ7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Cytoplasm|||Forms a ternary complex with ligand-binding receptor subunit IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane. Mature IL18 first binds to IL18R1 forming a low affinity binary complex, which then interacts with IL18RAP to form a high affinity ternary complex that signals inside the cell. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form. http://togogenome.org/gene/9796:KIF3A ^@ http://purl.uniprot.org/uniprot/A0A5F5PSZ1|||http://purl.uniprot.org/uniprot/A0A9L0S097|||http://purl.uniprot.org/uniprot/F6SR05 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9796:LOC100067990 ^@ http://purl.uniprot.org/uniprot/F6ZR94 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/9796:LOC100059537 ^@ http://purl.uniprot.org/uniprot/A0A9L0TQA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9796:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/Q29XY3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC100054852 ^@ http://purl.uniprot.org/uniprot/F6WFH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9796:MDC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RED8|||http://purl.uniprot.org/uniprot/A0A9L0SYF0|||http://purl.uniprot.org/uniprot/F7AQM7 ^@ Function ^@ Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. http://togogenome.org/gene/9796:LOC100050992 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZ24|||http://purl.uniprot.org/uniprot/A0A3Q2HQV6 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9796:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/F6Y7A5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9796:LOC100069198 ^@ http://purl.uniprot.org/uniprot/A0A5F5PUF1 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9796:NFE2 ^@ http://purl.uniprot.org/uniprot/F6SDZ5 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9796:ACP5 ^@ http://purl.uniprot.org/uniprot/F6WFF6 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/9796:CCL24 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KVU7 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9796:LOC100061851 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GVK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LBR ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9796:XKRX ^@ http://purl.uniprot.org/uniprot/A0A9L0S0U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9796:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SXX8 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9796:RNF168 ^@ http://purl.uniprot.org/uniprot/F7DJH7 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Belongs to the RNF168 family.|||E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with UBE2N/UBC13.|||Nucleus|||Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).|||The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).|||Ubiquitinated. http://togogenome.org/gene/9796:PRRT2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TPZ8|||http://purl.uniprot.org/uniprot/F6Z1R7 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9796:MED18 ^@ http://purl.uniprot.org/uniprot/F7CY64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9796:KDM4C ^@ http://purl.uniprot.org/uniprot/A0A3Q2HAR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9796:CYBB ^@ http://purl.uniprot.org/uniprot/F7DA90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CASP1 ^@ http://purl.uniprot.org/uniprot/Q9TV13 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C14A family.|||Cell membrane|||Cytoplasm|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit.|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (Caspase-1 subunit p20) and a 10 kDa (Caspase-1 subunit p10) subunit. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NLRP2 and whose function would be the activation of pro-inflammatory caspases. Component of the AIM2 PANoptosome complex, a multiprotein complex that drives inflammatory cell death (PANoptosis). Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17P/INCA and CARD18. Interacts with SERPINB1; this interaction regulates CASP1 activity.|||The two subunits are derived from the precursor sequence by an autocatalytic mechanism.|||Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly.|||Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8. http://togogenome.org/gene/9796:CACNG3 ^@ http://purl.uniprot.org/uniprot/F6V9P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/9796:PGM3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RJ03 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/9796:PER1 ^@ http://purl.uniprot.org/uniprot/F7AU00 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9796:SNRPC ^@ http://purl.uniprot.org/uniprot/A0A5F5PKW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/9796:CNTNAP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RH82 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||paranodal septate junction http://togogenome.org/gene/9796:LOC100034242 ^@ http://purl.uniprot.org/uniprot/P00327 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm|||Dimer of identical or non-identical chains of two types (E and S) coded by 2 separate genes at different loci. http://togogenome.org/gene/9796:SEMA3G ^@ http://purl.uniprot.org/uniprot/A0A9L0TEJ5 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:HTR2C ^@ http://purl.uniprot.org/uniprot/F6PSU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/A0A9L0TFC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNase I family.|||Nucleus envelope|||Zymogen granule http://togogenome.org/gene/9796:CD2 ^@ http://purl.uniprot.org/uniprot/P37998 ^@ Function|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.|||Cell membrane|||Expressed in spleen and thymus.|||Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (By similarity). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (By similarity). Interacts with FCGR3A; this interaction modulates NK cell activation and cytotoxicity. http://togogenome.org/gene/9796:GNMT ^@ http://purl.uniprot.org/uniprot/F6RBA4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/9796:DDIT3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SDB8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Cytoplasm|||Heterodimer.|||Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.|||Nucleus|||Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.|||Ubiquitinated, leading to its degradation by the proteasome. http://togogenome.org/gene/9796:FAM129A ^@ http://purl.uniprot.org/uniprot/A0A9L0THA7 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/9796:LOC100051036 ^@ http://purl.uniprot.org/uniprot/Q8MIP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ferritin family.|||Cytoplasm|||Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.|||Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). http://togogenome.org/gene/9796:LOC102147820 ^@ http://purl.uniprot.org/uniprot/F6UL34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ASPHD1 ^@ http://purl.uniprot.org/uniprot/F6QPY0 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/9796:LOC100067738 ^@ http://purl.uniprot.org/uniprot/F6W978 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CCNB1 ^@ http://purl.uniprot.org/uniprot/F6T9K2 ^@ Function|||Similarity ^@ Belongs to the cyclin family.|||Essential for the control of the cell cycle at the G2/M (mitosis) transition. http://togogenome.org/gene/9796:KRT24 ^@ http://purl.uniprot.org/uniprot/F6W8W3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:CAMK1 ^@ http://purl.uniprot.org/uniprot/F6YNX6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:CMBL ^@ http://purl.uniprot.org/uniprot/F6UL42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9796:THUMPD3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SD49 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9796:MASP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0T6M6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:TRIP10 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HU88|||http://purl.uniprot.org/uniprot/F6RQP4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9796:LOC100630401 ^@ http://purl.uniprot.org/uniprot/F6YEP7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:NOX3 ^@ http://purl.uniprot.org/uniprot/F6RG72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:TBX18 ^@ http://purl.uniprot.org/uniprot/A0A9L0S6D5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9796:FURIN ^@ http://purl.uniprot.org/uniprot/F7DHR9 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9796:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/F6QR15 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/9796:RPS9 ^@ http://purl.uniprot.org/uniprot/A0A9L0RA62 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9796:LOC100065718 ^@ http://purl.uniprot.org/uniprot/F7DLT3 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9796:CCL11 ^@ http://purl.uniprot.org/uniprot/Q9TTQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils (By similarity). Binds to CCR3 (By similarity).|||Secreted http://togogenome.org/gene/9796:CD3G ^@ http://purl.uniprot.org/uniprot/F7CUQ0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:NMUR1 ^@ http://purl.uniprot.org/uniprot/F6SBE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/9796:SLC37A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TGN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9796:KCNJ13 ^@ http://purl.uniprot.org/uniprot/F7CJ39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9796:LOC100062763 ^@ http://purl.uniprot.org/uniprot/F6VLY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:UCHL3 ^@ http://purl.uniprot.org/uniprot/A0A9R1SJZ0 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9796:PTGER2 ^@ http://purl.uniprot.org/uniprot/B2KNE0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:NUBP1 ^@ http://purl.uniprot.org/uniprot/F6T7P0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/9796:MSRB2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I0J0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9796:EGR3 ^@ http://purl.uniprot.org/uniprot/A0A5F5PJA0|||http://purl.uniprot.org/uniprot/F7BXS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9796:CYR61 ^@ http://purl.uniprot.org/uniprot/F6RUJ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:SEPT7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HTB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Filament-forming cytoskeletal GTPase.|||Midbody|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||cilium axoneme|||flagellum|||kinetochore|||spindle http://togogenome.org/gene/9796:NUDT2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TLJ2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9796:CCDC90B ^@ http://purl.uniprot.org/uniprot/L7MSF7 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9796:DLX3 ^@ http://purl.uniprot.org/uniprot/F7DMX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9796:B9D1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RMD9|||http://purl.uniprot.org/uniprot/F7BHN1 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9796:RAB3GAP1 ^@ http://purl.uniprot.org/uniprot/F6QUK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9796:DR1 ^@ http://purl.uniprot.org/uniprot/F6R635 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/9796:LOC102149570 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GYK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/9796:FLCN ^@ http://purl.uniprot.org/uniprot/A0A3Q2LPC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9796:IRGC ^@ http://purl.uniprot.org/uniprot/F7AN90 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/9796:NIF3L1 ^@ http://purl.uniprot.org/uniprot/F6UUP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/9796:FAM149B1 ^@ http://purl.uniprot.org/uniprot/F7DKL9 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9796:CCNB3 ^@ http://purl.uniprot.org/uniprot/K4Q4R0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9796:CLIC2 ^@ http://purl.uniprot.org/uniprot/F6UF33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Membrane http://togogenome.org/gene/9796:TUBD1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9796:FUT11 ^@ http://purl.uniprot.org/uniprot/A0A9L0R5R8|||http://purl.uniprot.org/uniprot/A0A9L0RBS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9796:RGS9 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q1G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:MS4A3 ^@ http://purl.uniprot.org/uniprot/F6W5Q5 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9796:PPP1R14D ^@ http://purl.uniprot.org/uniprot/F7DGQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/9796:CHST8 ^@ http://purl.uniprot.org/uniprot/F6W4B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:LOC100063912 ^@ http://purl.uniprot.org/uniprot/F7DES4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:EIF4EBP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T5V3 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/9796:PKN2 ^@ http://purl.uniprot.org/uniprot/F6S2E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/9796:ARPP19 ^@ http://purl.uniprot.org/uniprot/A0A5K1UUV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/9796:LOC100067155 ^@ http://purl.uniprot.org/uniprot/A0A5F5PMC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:GLA ^@ http://purl.uniprot.org/uniprot/F7B6D0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9796:AR ^@ http://purl.uniprot.org/uniprot/F6R5G1 ^@ Similarity ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily. http://togogenome.org/gene/9796:P19 ^@ http://purl.uniprot.org/uniprot/Q28388 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the calycin superfamily. Lipocalin family.|||Binds fatty acids and retinol. Is specialized for the preattachment embryo. May be important to maintain the pregnancy and may transport small hydrophobic ligands from mother to the developing embryo.|||Expressed in glandular and lumenal epithelia of the endometrium. Is transferred to the embryonic capsule, the conceptus and the yolk sac.|||Secreted http://togogenome.org/gene/9796:EIF4ENIF1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0T8|||http://purl.uniprot.org/uniprot/F7DND1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:DUPD1 ^@ http://purl.uniprot.org/uniprot/P0C592 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Cytoplasm|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways (By similarity).|||Homodimer (By similarity). Interacts with PRKAA2 (By similarity).|||Nucleus http://togogenome.org/gene/9796:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TLH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:GDF9 ^@ http://purl.uniprot.org/uniprot/A0A1P8DA98 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/9796:NTHL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TGP3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Interacts with YBX1.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9796:VPS45 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q1Q5|||http://purl.uniprot.org/uniprot/F7A212 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9796:GPR132 ^@ http://purl.uniprot.org/uniprot/F6Z8M2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:GOSR1 ^@ http://purl.uniprot.org/uniprot/F6YYT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9796:GDAP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SW65 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/9796:TLL2 ^@ http://purl.uniprot.org/uniprot/F7DMD5 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:DECR2 ^@ http://purl.uniprot.org/uniprot/F6RNB0 ^@ Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.|||Monomer, dimer and oligomer. http://togogenome.org/gene/9796:FAM168B ^@ http://purl.uniprot.org/uniprot/A0A9L0RB49 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9796:HNRNPF ^@ http://purl.uniprot.org/uniprot/F6X7G5 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9796:MTMR10 ^@ http://purl.uniprot.org/uniprot/A0A9L0TCL7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9796:SLC13A5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RDI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9796:LOC100068923 ^@ http://purl.uniprot.org/uniprot/A0A9L0TM32 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9796:NDST4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HV39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9796:PLRG1 ^@ http://purl.uniprot.org/uniprot/K9K2C7|||http://purl.uniprot.org/uniprot/L7MSE9 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9796:ELF2 ^@ http://purl.uniprot.org/uniprot/F6X830 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:KCNMB2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I792|||http://purl.uniprot.org/uniprot/A0A9L0SGU8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9796:ANXA3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SID4 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9796:MICAL1 ^@ http://purl.uniprot.org/uniprot/F7DYV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/9796:MYH1 ^@ http://purl.uniprot.org/uniprot/Q8MJV0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).|||Muscle contraction.|||Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).|||Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).|||The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.|||myofibril http://togogenome.org/gene/9796:ARRB1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWH7|||http://purl.uniprot.org/uniprot/F6SLQ7 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9796:MED14 ^@ http://purl.uniprot.org/uniprot/A0A5F5PGI5|||http://purl.uniprot.org/uniprot/F7C7L4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9796:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HHV2|||http://purl.uniprot.org/uniprot/A0A9L0T0E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:PSIP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RFV5|||http://purl.uniprot.org/uniprot/A1YAF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/9796:ANXA1 ^@ http://purl.uniprot.org/uniprot/Q8HZM6 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasm|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.|||Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation. Homodimers linked by transglutamylation are observed in placenta, but not in other tissues. Interacts with S100A11. Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (By similarity). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).|||Lateral cell membrane|||Membrane|||Nucleus|||Phosphorylated by protein kinase C, EGFR and TRPM7. Phosphorylated in response to EGF treatment.|||Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).|||Proteolytically cleaved by cathepsin CTSG to release the active N-terminal peptide Ac2-26.|||Secreted|||Sumoylated.|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||Was originally identified as calcium and phospholipid binding protein that displays Ca(2+)-dependent binding to phospholipid membranes and can promote membrane aggregation in vitro. Was initially identified as inhibitor of phospholipase A2 activity (in vitro). Inhibition of phospholipase activity is mediated via its phospholipid binding activity that limits the access of phospholipase to its substrates.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9796:DNAL4 ^@ http://purl.uniprot.org/uniprot/A0A9L0RN98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9796:KPNA5 ^@ http://purl.uniprot.org/uniprot/F7DMT7 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9796:MOGAT1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SK43 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:FMO5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RAI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.|||Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9796:CACNG7 ^@ http://purl.uniprot.org/uniprot/F6QL00 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. http://togogenome.org/gene/9796:HNRNPA1 ^@ http://purl.uniprot.org/uniprot/F6YZ44|||http://purl.uniprot.org/uniprot/K9K211 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9796:TMEM9B ^@ http://purl.uniprot.org/uniprot/A0A9L0T032 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9796:FLVCR1 ^@ http://purl.uniprot.org/uniprot/F6PHV8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:GABRG1 ^@ http://purl.uniprot.org/uniprot/F6ZRR6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:ZC2HC1C ^@ http://purl.uniprot.org/uniprot/A0A3Q2HRI2|||http://purl.uniprot.org/uniprot/A0A9L0TRE2|||http://purl.uniprot.org/uniprot/F6QP06 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/9796:DEGS2 ^@ http://purl.uniprot.org/uniprot/F6VWM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:MUT ^@ http://purl.uniprot.org/uniprot/F6V4C7 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/9796:RPP30 ^@ http://purl.uniprot.org/uniprot/K9KFS0 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/9796:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HTM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:TBP ^@ http://purl.uniprot.org/uniprot/F6UBP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9796:CDK5R1 ^@ http://purl.uniprot.org/uniprot/F6XY71 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Cell membrane|||Heterodimer of a catalytic subunit and a regulatory subunit.|||Membrane http://togogenome.org/gene/9796:ZNF165 ^@ http://purl.uniprot.org/uniprot/F6ZJD1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:VIPR1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ICC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:CHMP3 ^@ http://purl.uniprot.org/uniprot/F7DFE3 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9796:GPR21 ^@ http://purl.uniprot.org/uniprot/A0A9L0THM2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:TDRD5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HTG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDRD5 family.|||Cytoplasm|||Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. http://togogenome.org/gene/9796:LOC100064042 ^@ http://purl.uniprot.org/uniprot/F6Y9Z0 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9796:RETREG3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SM37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/F6UT45 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/9796:RDX ^@ http://purl.uniprot.org/uniprot/A0A5F5PP99 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton|||microvillus http://togogenome.org/gene/9796:ACTR1A ^@ http://purl.uniprot.org/uniprot/K9K3P7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:CXCL8 ^@ http://purl.uniprot.org/uniprot/F6U909|||http://purl.uniprot.org/uniprot/O62812 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways.|||Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.|||Homodimer.|||Homodimer. Interacts with TNFAIP6 (via Link domain); this interaction interferes with chemokine binding to glycosaminoglycans.|||Secreted http://togogenome.org/gene/9796:LOC100050361 ^@ http://purl.uniprot.org/uniprot/A0A5F5PM22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9796:FDPS ^@ http://purl.uniprot.org/uniprot/A0A3Q2L3W8|||http://purl.uniprot.org/uniprot/K9K3N0 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9796:LGB2 ^@ http://purl.uniprot.org/uniprot/P07380 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.|||Monomer.|||Secreted http://togogenome.org/gene/9796:CACNG1 ^@ http://purl.uniprot.org/uniprot/F6Q9C0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/9796:SLC5A11 ^@ http://purl.uniprot.org/uniprot/A0A9L0RKG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:OGFOD1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SN04 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/9796:CUZD1 ^@ http://purl.uniprot.org/uniprot/F7D2L3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ZRANB2 ^@ http://purl.uniprot.org/uniprot/F7APL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9796:LOC100034197 ^@ http://purl.uniprot.org/uniprot/Q95182 ^@ Allergen|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Analysis of the sugar composition shows the presence of GalNAc, Gal, NeuAc, GlcNAc, and Man. May be also O-glycosylated.|||Belongs to the calycin superfamily. Lipocalin family.|||Causes an allergic reaction in human. Potent allergen responsible for about 80% of anti-horse IgE antibody response in patients who are chronically exposed to horse allergens.|||Expressed in liver and in sublingual and submaxillary salivary glands. Highly concentrated in secretory fluid such as saliva and urine as well as in hair dandruff extract.|||Homodimer.|||Secreted|||Several N-terminal ends may be due to cleavage by signal peptidase at different sites or may be generated by proteolytic processing of the secreted protein. http://togogenome.org/gene/9796:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/F6Y1M3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9796:RDH11 ^@ http://purl.uniprot.org/uniprot/A0A9L0RN16 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:MTTP ^@ http://purl.uniprot.org/uniprot/F6PMI6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:SV2A ^@ http://purl.uniprot.org/uniprot/A0A3Q2I9I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9796:HDAC9 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LFI5|||http://purl.uniprot.org/uniprot/A0A9L0RVU1|||http://purl.uniprot.org/uniprot/F6ZE39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus http://togogenome.org/gene/9796:NLGN3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HTM9|||http://purl.uniprot.org/uniprot/A0A9L0RUK5|||http://purl.uniprot.org/uniprot/F6UIF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:B3GALT4 ^@ http://purl.uniprot.org/uniprot/A0A9L0S2A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:ASIC3 ^@ http://purl.uniprot.org/uniprot/E1A463 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100055427 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I180 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:AKAP5 ^@ http://purl.uniprot.org/uniprot/F6YIT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:NTSR1 ^@ http://purl.uniprot.org/uniprot/F7BSR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:SLC26A7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GTL1|||http://purl.uniprot.org/uniprot/A0A9L0TGT5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:LDHD ^@ http://purl.uniprot.org/uniprot/F6QED3 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/9796:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A9L0RAQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/9796:MRPL11 ^@ http://purl.uniprot.org/uniprot/F7AQF6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9796:COX7A2L ^@ http://purl.uniprot.org/uniprot/K9K1Y7 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9796:C2H1orf123 ^@ http://purl.uniprot.org/uniprot/A0A5F5PET2|||http://purl.uniprot.org/uniprot/A0A9L0RKL4 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9796:P3H2 ^@ http://purl.uniprot.org/uniprot/F6YCX7 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/9796:GTPBP8 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IAW8|||http://purl.uniprot.org/uniprot/F6R4P0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. http://togogenome.org/gene/9796:LOC100067437 ^@ http://purl.uniprot.org/uniprot/F6TZW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CEL ^@ http://purl.uniprot.org/uniprot/A0A9L0S664 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9796:TPPP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TT02 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9796:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SMN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9796:LOC100057798 ^@ http://purl.uniprot.org/uniprot/F7ABR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MIP ^@ http://purl.uniprot.org/uniprot/F6T7W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PJVK ^@ http://purl.uniprot.org/uniprot/A0A9L0SVB7 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/9796:ENO4 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q3B5 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/9796:TAF1 ^@ http://purl.uniprot.org/uniprot/F7DCN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/9796:HS3ST5 ^@ http://purl.uniprot.org/uniprot/F6PP00 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SR27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:BEST3 ^@ http://purl.uniprot.org/uniprot/A0A9L0TCM2|||http://purl.uniprot.org/uniprot/F6TI80 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:UTP3 ^@ http://purl.uniprot.org/uniprot/F6QJZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAS10 family.|||nucleolus http://togogenome.org/gene/9796:TAF13 ^@ http://purl.uniprot.org/uniprot/K9K238 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:ENKUR ^@ http://purl.uniprot.org/uniprot/F6VQA4 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9796:LOC100061296 ^@ http://purl.uniprot.org/uniprot/F6WN36 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9796:CHRND ^@ http://purl.uniprot.org/uniprot/F6VC36 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:RHBDD1 ^@ http://purl.uniprot.org/uniprot/F7CEC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ING3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HY41 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9796:ATP7B ^@ http://purl.uniprot.org/uniprot/A0A3Q2HCM8|||http://purl.uniprot.org/uniprot/A0A3Q2HTT2|||http://purl.uniprot.org/uniprot/A0A9L0TFT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9796:BCL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SK61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion outer membrane|||Nucleus membrane http://togogenome.org/gene/9796:TRIM45 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GSY5|||http://purl.uniprot.org/uniprot/F6RUP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9796:BMX ^@ http://purl.uniprot.org/uniprot/A0A3Q2HYV1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9796:PFDN1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HUZ2 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/9796:ST6GALNAC6 ^@ http://purl.uniprot.org/uniprot/A0A9L0SCM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9796:PDE4D ^@ http://purl.uniprot.org/uniprot/A0A5F5PZW9|||http://purl.uniprot.org/uniprot/A0A5F5Q0J1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9796:AP4B1 ^@ http://purl.uniprot.org/uniprot/F6YPY8 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9796:RSPO3 ^@ http://purl.uniprot.org/uniprot/A8C9U2 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9796:SGTB ^@ http://purl.uniprot.org/uniprot/A0A9L0TGT3 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/9796:NUP35 ^@ http://purl.uniprot.org/uniprot/K9K270 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9796:TMEM205 ^@ http://purl.uniprot.org/uniprot/A0A9L0TBL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/9796:LOC100063866 ^@ http://purl.uniprot.org/uniprot/F7BTX8 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9796:BDH1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TKN3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:TLR7 ^@ http://purl.uniprot.org/uniprot/A1XC20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Endosome|||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.|||Lysosome|||Membrane|||phagosome http://togogenome.org/gene/9796:LOC102149481 ^@ http://purl.uniprot.org/uniprot/A0A9L0SA84|||http://purl.uniprot.org/uniprot/F6VUH0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:PHOSPHO1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TMD8|||http://purl.uniprot.org/uniprot/A0A9L0TNI7|||http://purl.uniprot.org/uniprot/F6XQJ9 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9796:LOC102148983 ^@ http://purl.uniprot.org/uniprot/A0A9L0T5E7 ^@ Similarity ^@ Belongs to the TEX13 family. http://togogenome.org/gene/9796:SLC12A9 ^@ http://purl.uniprot.org/uniprot/F7CII4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9796:LOC100052921 ^@ http://purl.uniprot.org/uniprot/P05006 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.|||Secreted http://togogenome.org/gene/9796:HSPB6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HPI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:LOC100071074 ^@ http://purl.uniprot.org/uniprot/F6QB61 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/9796:MMAB ^@ http://purl.uniprot.org/uniprot/A0A3Q2L7N9 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/9796:RBM46 ^@ http://purl.uniprot.org/uniprot/A0A9L0SVG5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:GJA5 ^@ http://purl.uniprot.org/uniprot/F7BKC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A9L0T3D0 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9796:LOC100052031 ^@ http://purl.uniprot.org/uniprot/F7AAU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LY49C ^@ http://purl.uniprot.org/uniprot/Q75XR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:FUCA2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RV42 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9796:STK17B ^@ http://purl.uniprot.org/uniprot/A0A3Q2GXD2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:FXYD5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HLX1 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9796:LYRM7 ^@ http://purl.uniprot.org/uniprot/K9K4D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9796:LOC100053263 ^@ http://purl.uniprot.org/uniprot/F6WPA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:SERPINA6 ^@ http://purl.uniprot.org/uniprot/A0A9L0R6S7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:CADM4 ^@ http://purl.uniprot.org/uniprot/A0A9L0TK28 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9796:C18H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A9L0RBU2 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/9796:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SPK0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/9796:LOC100071061 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4N0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9796:EYA1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HDE8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9796:ZHX2 ^@ http://purl.uniprot.org/uniprot/F6TC07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9796:PATL1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I789 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9796:HMGB1 ^@ http://purl.uniprot.org/uniprot/K9K2L5|||http://purl.uniprot.org/uniprot/Q08IE6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity).|||Belongs to the HMGB family.|||Cell membrane|||Chromosome|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Endosome|||Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.|||HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.|||In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.|||In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B cell responses to endogenous TLR9 ligands through a B-cell receptor (BCR)-dependent and ACER/RAGE-independent mechanism. Inhibits phagocytosis of apoptotic cells by macrophages; the function is dependent on poly-ADP-ribosylation and involves binding to phosphatidylserine on the cell surface of apoptotic cells. In adaptive immunity may be involved in enhancing immunity through activation of effector T-cells and suppression of regulatory T (TReg) cells. In contrast, without implicating effector or regulatory T-cells, required for tumor infiltration and activation of T-cells expressing the lymphotoxin LTA:LTB heterotrimer thus promoting tumor malignant progression. Also reported to limit proliferation of T-cells. Released HMGB1:nucleosome complexes formed during apoptosis can signal through TLR2 to induce cytokine production. Involved in induction of immunological tolerance by apoptotic cells; its pro-inflammatory activities when released by apoptotic cells are neutralized by reactive oxygen species (ROS)-dependent oxidation specifically on Cys-106. During macrophage activation by activated lymphocyte-derived self apoptotic DNA (ALD-DNA) promotes recruitment of ALD-DNA to endosomes.|||In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).|||Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export. Interacts with receptor RAGE/AGER (By similarity).|||Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins.|||Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance.|||Nucleus|||Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.|||Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS (By similarity).|||Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).|||Secreted|||The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins. http://togogenome.org/gene/9796:LOC100068729 ^@ http://purl.uniprot.org/uniprot/F7AK35 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9796:LOC100062768 ^@ http://purl.uniprot.org/uniprot/A0A9L0QZE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9796:TMOD4 ^@ http://purl.uniprot.org/uniprot/F6ZCV2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9796:SAP18 ^@ http://purl.uniprot.org/uniprot/F7AC40 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/9796:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/F6VB64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIN1 family.|||Cytoplasmic vesicle http://togogenome.org/gene/9796:PRPS1 ^@ http://purl.uniprot.org/uniprot/K9K4A1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9796:NTRK2 ^@ http://purl.uniprot.org/uniprot/F6QPZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9796:CHMP1B ^@ http://purl.uniprot.org/uniprot/A0A9L0RKV5 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9796:CDH7 ^@ http://purl.uniprot.org/uniprot/F6U735 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:EBF2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SF48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9796:SLC7A8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SDD5|||http://purl.uniprot.org/uniprot/A0A9L0TIQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:KEF40_p08 ^@ http://purl.uniprot.org/uniprot/P48662|||http://purl.uniprot.org/uniprot/Q6J6X0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct (By similarity).|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:FGF9 ^@ http://purl.uniprot.org/uniprot/F7B6A2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:OSBPL3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HWR6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9796:CLDN25 ^@ http://purl.uniprot.org/uniprot/F7CTQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9796:SLC5A2 ^@ http://purl.uniprot.org/uniprot/F6S4E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:SPSB1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TFB0 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/9796:LOC100068096 ^@ http://purl.uniprot.org/uniprot/F6UQX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PSMD1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RJ47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9796:NXPE1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RA96 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9796:LSM4 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9796:PCNX4 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q002|||http://purl.uniprot.org/uniprot/F7D421 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9796:SLC2A1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HV80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/9796:OAS2 ^@ http://purl.uniprot.org/uniprot/Q6R757 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9796:MMP16 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q4Q2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9796:TAAR5 ^@ http://purl.uniprot.org/uniprot/F6Z9Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9796:CALHM5 ^@ http://purl.uniprot.org/uniprot/F6U6K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9796:LMNA ^@ http://purl.uniprot.org/uniprot/F6ZY40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9796:FAM3D ^@ http://purl.uniprot.org/uniprot/A0A3Q2HVV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9796:LOC100069649 ^@ http://purl.uniprot.org/uniprot/F6SPZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SLC27A6 ^@ http://purl.uniprot.org/uniprot/F7CKE7 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9796:S100B ^@ http://purl.uniprot.org/uniprot/F6RF49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9796:CENPI ^@ http://purl.uniprot.org/uniprot/F6ZC44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-I/CTF3 family.|||Nucleus|||centromere http://togogenome.org/gene/9796:ZFP69B ^@ http://purl.uniprot.org/uniprot/F6T5P9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:UGT2A2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IG22|||http://purl.uniprot.org/uniprot/A0A3Q2ILW1|||http://purl.uniprot.org/uniprot/F7D123 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9796:TMEM94 ^@ http://purl.uniprot.org/uniprot/F6YI77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:C3H16orf70 ^@ http://purl.uniprot.org/uniprot/A0A9L0RRB3 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/9796:BCL2L13 ^@ http://purl.uniprot.org/uniprot/F6QLG3 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9796:LOC100056985 ^@ http://purl.uniprot.org/uniprot/F7E310 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:STEAP4 ^@ http://purl.uniprot.org/uniprot/F7A3D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9796:SLC4A5 ^@ http://purl.uniprot.org/uniprot/F6VRH5 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9796:LDHA ^@ http://purl.uniprot.org/uniprot/B7XH73 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9796:TNFSF10 ^@ http://purl.uniprot.org/uniprot/A0A060GP82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9796:PAQR7 ^@ http://purl.uniprot.org/uniprot/F7DAQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9796:C7H11orf88 ^@ http://purl.uniprot.org/uniprot/F6VXR2 ^@ Similarity ^@ Belongs to the HOATZ family. http://togogenome.org/gene/9796:ALG8 ^@ http://purl.uniprot.org/uniprot/K9KBB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:SPECC1L ^@ http://purl.uniprot.org/uniprot/A0A5F5PGL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/9796:LOC100067396 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HIK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:AQP8 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KRK3|||http://purl.uniprot.org/uniprot/A0A9L0RKJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:HIGD1A ^@ http://purl.uniprot.org/uniprot/K9KG26 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9796:SERPINF1 ^@ http://purl.uniprot.org/uniprot/B8K250 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:TM4SF5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RC05|||http://purl.uniprot.org/uniprot/F6YH60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9796:LOC100629823 ^@ http://purl.uniprot.org/uniprot/F6PR72 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:MEF2A ^@ http://purl.uniprot.org/uniprot/F6ZR05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LALBA ^@ http://purl.uniprot.org/uniprot/A0A5F5PQV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 22 family.|||Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9796:NUDC ^@ http://purl.uniprot.org/uniprot/A0A3Q2HW84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/9796:SH3YL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RQP2 ^@ Similarity|||Subunit ^@ Belongs to the SH3YL1 family.|||Interacts with SH3D19. http://togogenome.org/gene/9796:AMZ1 ^@ http://purl.uniprot.org/uniprot/F6QZ01 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9796:ERBB2 ^@ http://purl.uniprot.org/uniprot/F6VNY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9796:LOC100051073 ^@ http://purl.uniprot.org/uniprot/F7DYB1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9796:LOC100072163 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GY32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MMP20 ^@ http://purl.uniprot.org/uniprot/F7BFH0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9796:SPIC ^@ http://purl.uniprot.org/uniprot/F6XL56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:ANG ^@ http://purl.uniprot.org/uniprot/Q5VI84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pancreatic ribonuclease family.|||Homodimer. Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur (By similarity).|||Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.|||Secreted|||nucleolus|||secretory vesicle lumen http://togogenome.org/gene/9796:MUS81 ^@ http://purl.uniprot.org/uniprot/A0A9L0RWQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/9796:CARMIL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RXN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9796:LOC100058979 ^@ http://purl.uniprot.org/uniprot/F6U9J2|||http://purl.uniprot.org/uniprot/F6ZQW8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/9796:TCTA ^@ http://purl.uniprot.org/uniprot/F7AIF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane http://togogenome.org/gene/9796:TCEANC ^@ http://purl.uniprot.org/uniprot/F6S754 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:SLC28A2 ^@ http://purl.uniprot.org/uniprot/F6Q3A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9796:LOC100067901 ^@ http://purl.uniprot.org/uniprot/F6U1Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CCL3 ^@ http://purl.uniprot.org/uniprot/B1AB88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9796:KEF40_p01 ^@ http://purl.uniprot.org/uniprot/P48665|||http://purl.uniprot.org/uniprot/Q53YR5 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme b groups non-covalently.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.|||The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. http://togogenome.org/gene/9796:SNX20 ^@ http://purl.uniprot.org/uniprot/A0A9L0RNQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Membrane http://togogenome.org/gene/9796:YIPF1 ^@ http://purl.uniprot.org/uniprot/F7A1P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9796:PRKCQ ^@ http://purl.uniprot.org/uniprot/A0A5F5PWV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9796:CD53 ^@ http://purl.uniprot.org/uniprot/L7MS00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9796:HAUS1 ^@ http://purl.uniprot.org/uniprot/F6WUC4|||http://purl.uniprot.org/uniprot/K9K3L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/9796:SLC9A1 ^@ http://purl.uniprot.org/uniprot/F7BH15 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100055518 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IBH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NBR1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H8U4 ^@ Subcellular Location Annotation ^@ Lysosome|||autophagosome http://togogenome.org/gene/9796:HAL ^@ http://purl.uniprot.org/uniprot/A0A3Q2GU92|||http://purl.uniprot.org/uniprot/F6TGW2 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9796:LOC100059700 ^@ http://purl.uniprot.org/uniprot/A0A5F5PP78 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:EDEM2 ^@ http://purl.uniprot.org/uniprot/F7BF37 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9796:PRPF31 ^@ http://purl.uniprot.org/uniprot/F6T5B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Cajal body http://togogenome.org/gene/9796:IMMT ^@ http://purl.uniprot.org/uniprot/A0A3Q2GV85|||http://purl.uniprot.org/uniprot/A0A3Q2HMN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:RPS2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q172 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/9796:OOSP2 ^@ http://purl.uniprot.org/uniprot/F6U050 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9796:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/F6VU60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9796:HTR1B ^@ http://purl.uniprot.org/uniprot/Q0EAB5 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.|||Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).|||Homodimer. Heterodimer with HTR1D (By similarity).|||Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.|||Palmitoylated.|||Phosphorylated. http://togogenome.org/gene/9796:OSGEPL1 ^@ http://purl.uniprot.org/uniprot/F7A1U7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Mitochondrion|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/9796:CSF3R ^@ http://purl.uniprot.org/uniprot/A0A9L0T4H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9796:CTNNB1 ^@ http://purl.uniprot.org/uniprot/B1MV73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/9796:ST13 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HLY5 ^@ Similarity ^@ Belongs to the FAM10 family. http://togogenome.org/gene/9796:ORC6 ^@ http://purl.uniprot.org/uniprot/F7CMF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9796:BDNF ^@ http://purl.uniprot.org/uniprot/Q0EAB7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NGF-beta family.|||Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).|||Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.|||Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG).|||Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. Can form heterodimers with other neurotrophin family members, such as NTF3 and NTF4 (in vitro), but the physiological relevance of this is not clear (By similarity). BDNF precursor form: interacts with the heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower affinity for the heterodimer formed by NGFR and SORCS2 (By similarity).|||N-glycosylated and glycosulfated, contrary to mature BDNF.|||Secreted http://togogenome.org/gene/9796:GPAM ^@ http://purl.uniprot.org/uniprot/A0A9L0RK03|||http://purl.uniprot.org/uniprot/A0A9L0TCA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/9796:HSPB9 ^@ http://purl.uniprot.org/uniprot/A0A9L0TKD9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/9796:FOLR3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4A7 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9796:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A9L0S3L0 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9796:CTNS ^@ http://purl.uniprot.org/uniprot/A0A9L0SHG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/9796:HSDL2 ^@ http://purl.uniprot.org/uniprot/F6PQF9 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9796:IL1A ^@ http://purl.uniprot.org/uniprot/F7C3T8|||http://purl.uniprot.org/uniprot/Q28385 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated within its nuclear localization sequence, which impacts subcellular localization.|||Belongs to the IL-1 family.|||Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.|||Cytoplasm|||Monomer. Interacts with TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. Interacts with IL1R1. Interacts with S100A13; this interaction is the first step in the export of IL1A, followed by direct translocation of this complex across the plasma membrane.|||Nucleus|||Phosphorylated. Phosphorylation greatly enhances susceptibility to digestion and promotes the conversion of pre-IL1A alpha to the biologically active IL1A.|||Proteolytic processed by CAPN1 in a calcium-dependent manner. Cleavage from 31 kDa precursor to 18 kDa biologically active molecules.|||Secreted|||The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. http://togogenome.org/gene/9796:LOC100057212 ^@ http://purl.uniprot.org/uniprot/F6QZ61 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9796:C1S ^@ http://purl.uniprot.org/uniprot/F7BQD6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:PTH1R ^@ http://purl.uniprot.org/uniprot/A0A9L0SWH5|||http://purl.uniprot.org/uniprot/A0A9L0T9L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100629859 ^@ http://purl.uniprot.org/uniprot/A0A7R8GUY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:LOC100061997 ^@ http://purl.uniprot.org/uniprot/F6YHH0 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9796:STPG4 ^@ http://purl.uniprot.org/uniprot/A0A9L0S2C9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9796:EMG1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SB07 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9796:SLC16A13 ^@ http://purl.uniprot.org/uniprot/F7BXP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG22 family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/9796:ACSF3 ^@ http://purl.uniprot.org/uniprot/F7DM96 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9796:AMBP ^@ http://purl.uniprot.org/uniprot/A0A5F5PEG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Endoplasmic reticulum|||In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.|||Membrane|||Mitochondrion inner membrane|||Monomer. Also occurs as a complex with tryptase in mast cells.|||Nucleus membrane|||cytosol|||extracellular matrix http://togogenome.org/gene/9796:SYNPR ^@ http://purl.uniprot.org/uniprot/A0A3Q2HAB7|||http://purl.uniprot.org/uniprot/A0A9L0RPQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9796:EID3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T313 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/9796:DLGAP4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SFS1 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9796:FAM46C ^@ http://purl.uniprot.org/uniprot/A0A9L0S805 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9796:LAPTM4A ^@ http://purl.uniprot.org/uniprot/F6X1D5 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/9796:SLCO1B3 ^@ http://purl.uniprot.org/uniprot/A0A0E8PL88|||http://purl.uniprot.org/uniprot/F6SUK0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:KATNAL2 ^@ http://purl.uniprot.org/uniprot/F6PIY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/9796:INPP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RNN9 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9796:LOC100062735 ^@ http://purl.uniprot.org/uniprot/F7CQD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9796:LOC100064703 ^@ http://purl.uniprot.org/uniprot/F6RP73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9796:SLC17A2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IFA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CES3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HQC5 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9796:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S9R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9796:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A9L0TJU2 ^@ Similarity ^@ Belongs to the DIM1 family. http://togogenome.org/gene/9796:U2AF2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S799|||http://purl.uniprot.org/uniprot/A0A9L0TUH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the splicing factor SR family.|||Necessary for the splicing of pre-mRNA.|||Nucleus http://togogenome.org/gene/9796:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RE94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:NPPA ^@ http://purl.uniprot.org/uniprot/P27104 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Cleavage by MME initiates degradation of the factor and thereby regulates its activity. Degradation by IDE results in reduced activation of NPR1 (in vitro). During IDE degradation, the resulting products can temporarily stimulate NPR2 to produce cGMP, before the fragments are completely degraded and inactivated by IDE (in vitro).|||Degraded by IDE.|||Homodimer; disulfide-linked antiparallel dimer.|||Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney.|||Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (By similarity). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity).|||May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption.|||May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity).|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Perikaryon|||Phosphorylation on Ser-129 decreases vasorelaxant activity.|||Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, a heterologous and in vivo expression study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).|||Results concerning the involvement of this peptide in blood volume and blood pressure homeostasis are conflicting. Several studies utilising in vitro and heterologous expression systems show that it is able to activate cGMP and promote vasodilation and natriuresis (By similarity). However, an in vivo study in rat found that it is not sufficient to induce any diuretic, natriuretic, nor hypotensive responses, and is unable to bind NPR1 nor increase guanylyl cyclase activity (By similarity).|||Secreted|||The precursor molecule is proteolytically cleaved by CORIN at Arg-123 to produce the atrial natriuretic peptide (By similarity). Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natriuretic peptide, vessel dilator and kaliuretic peptide (By similarity). Additional processing gives rise to the auriculin and atriopeptin peptides (By similarity). In the kidneys, alternative processing by an unknown protease results in the peptide urodilatin (By similarity). http://togogenome.org/gene/9796:RFFL ^@ http://purl.uniprot.org/uniprot/A0A9L0SRL4|||http://purl.uniprot.org/uniprot/A0A9L0STJ1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9796:GAB1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IJS9 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9796:RAB19 ^@ http://purl.uniprot.org/uniprot/F6TDT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9796:LOC100053259 ^@ http://purl.uniprot.org/uniprot/F6Y7V5 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:RRAGA ^@ http://purl.uniprot.org/uniprot/A0A3Q2H8X1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9796:LOC100050329 ^@ http://purl.uniprot.org/uniprot/F6VIF4 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:CILP2 ^@ http://purl.uniprot.org/uniprot/F7CCP9 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9796:HAMP ^@ http://purl.uniprot.org/uniprot/D1KKA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/9796:PDE6G ^@ http://purl.uniprot.org/uniprot/F7BEA5 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9796:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H334 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9796:MX1 ^@ http://purl.uniprot.org/uniprot/F6QLQ9|||http://purl.uniprot.org/uniprot/Q28379 ^@ Domain|||Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||By type I and type III interferons.|||Cytoplasm|||Endoplasmic reticulum membrane|||Homooligomer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures (By similarity). Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (By similarity). Interacts with HSPA5 (By similarity). Interacts with TUBB/TUBB5 (By similarity). Interacts with DDX39A and DDX39B (By similarity).|||ISGylated.|||Interferon-induced dynamin-like GTPase with antiviral activity.|||The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.|||The middle domain mediates self-assembly and oligomerization.|||perinuclear region http://togogenome.org/gene/9796:SLC11A1 ^@ http://purl.uniprot.org/uniprot/Q95N75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. http://togogenome.org/gene/9796:LHFPL5 ^@ http://purl.uniprot.org/uniprot/A0A9L0R155 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:SMIM14 ^@ http://purl.uniprot.org/uniprot/F7DJY5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9796:LOC100050266 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LBK1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:RTCB ^@ http://purl.uniprot.org/uniprot/K9K9E5 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/9796:DDX53 ^@ http://purl.uniprot.org/uniprot/A0A9L0R2W3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9796:LOC100062850 ^@ http://purl.uniprot.org/uniprot/F7DJ08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:COMP ^@ http://purl.uniprot.org/uniprot/Q9BG80 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:GMPR2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PLT3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9796:ARL14 ^@ http://purl.uniprot.org/uniprot/F7DHA6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9796:DNASE1 ^@ http://purl.uniprot.org/uniprot/Q4AEE3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNase I family.|||Divalent metal cations. Prefers Ca(2+) or Mg(2+).|||Nucleus envelope|||Secreted|||Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (By similarity). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).|||Zymogen granule http://togogenome.org/gene/9796:CHST4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HU28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9796:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RWR3 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/9796:C4H7orf25 ^@ http://purl.uniprot.org/uniprot/F6ULF1 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/9796:XIAP ^@ http://purl.uniprot.org/uniprot/F7BTS0 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9796:DYRK4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SBC4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/9796:GAPDHS ^@ http://purl.uniprot.org/uniprot/A0A3Q2LU41|||http://purl.uniprot.org/uniprot/A0A5F5PLD3 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9796:CDX4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I356 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/9796:DEDD ^@ http://purl.uniprot.org/uniprot/A0A9L0T4Z5 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9796:CRABP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TEM4 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9796:TNFSF8 ^@ http://purl.uniprot.org/uniprot/F7D2X3 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9796:FAM171B ^@ http://purl.uniprot.org/uniprot/F6RNK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/9796:LOC100630617 ^@ http://purl.uniprot.org/uniprot/A0A9L0TBD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9796:FTL ^@ http://purl.uniprot.org/uniprot/P02791 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the ferritin family.|||In horse spleen the light chain is the major chain.|||Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). http://togogenome.org/gene/9796:LOC100055965 ^@ http://purl.uniprot.org/uniprot/A0A9L0SEF2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9796:CLDN16 ^@ http://purl.uniprot.org/uniprot/F6XTZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9796:SLC46A3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HZ33|||http://purl.uniprot.org/uniprot/F7AKM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100067462 ^@ http://purl.uniprot.org/uniprot/F6TT29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HY27 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:ACTL6B ^@ http://purl.uniprot.org/uniprot/A0A9L0S046 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:CEMIP ^@ http://purl.uniprot.org/uniprot/A0A3Q2HLI5 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9796:C3AR1 ^@ http://purl.uniprot.org/uniprot/F6YIS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9796:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TI13 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:DAPK2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HPG2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:AGTR2 ^@ http://purl.uniprot.org/uniprot/F7AV47 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/9796:HYAL2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H6H1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9796:PHACTR4 ^@ http://purl.uniprot.org/uniprot/A0A9L0S012|||http://purl.uniprot.org/uniprot/F6U243 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.|||lamellipodium http://togogenome.org/gene/9796:USP3 ^@ http://purl.uniprot.org/uniprot/A5YBM4 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9796:LOC102150902 ^@ http://purl.uniprot.org/uniprot/A0A9L0RF83 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:ATP13A1 ^@ http://purl.uniprot.org/uniprot/F6VB73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/9796:SERPIND1 ^@ http://purl.uniprot.org/uniprot/F7BM31 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:EIF3D ^@ http://purl.uniprot.org/uniprot/F6VVG6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9796:GPR6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RKU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100069365 ^@ http://purl.uniprot.org/uniprot/F6YSH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:RRP15 ^@ http://purl.uniprot.org/uniprot/F6SAF6 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/9796:LOC100629205 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I071 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DTX3 ^@ http://purl.uniprot.org/uniprot/F6TMV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9796:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A9L0R6I2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9796:LOC100053913 ^@ http://purl.uniprot.org/uniprot/F6ZJ14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:WASF1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RC36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9796:CAPN13 ^@ http://purl.uniprot.org/uniprot/F6YBE6 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9796:EEF1G ^@ http://purl.uniprot.org/uniprot/A2Q127 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/9796:ANXA13 ^@ http://purl.uniprot.org/uniprot/F6PT14 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9796:ANO6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IDT2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:LOC100066499 ^@ http://purl.uniprot.org/uniprot/F7BYN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ATP5PD ^@ http://purl.uniprot.org/uniprot/A0A9L0RP12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:ADPRM ^@ http://purl.uniprot.org/uniprot/A0A9L0RMT1 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/9796:AXL ^@ http://purl.uniprot.org/uniprot/F6VEV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/9796:MTHFD1 ^@ http://purl.uniprot.org/uniprot/F6YIU8 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/9796:KCNE1 ^@ http://purl.uniprot.org/uniprot/F6WR21 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the potassium channel KCNE family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:GHITM ^@ http://purl.uniprot.org/uniprot/K9K4F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9796:LOC100034175 ^@ http://purl.uniprot.org/uniprot/P00328 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm|||Dimer of identical or non-identical chains of two types (E and S) coded by 2 separate genes at different loci. http://togogenome.org/gene/9796:DPYSL3 ^@ http://purl.uniprot.org/uniprot/F6WC66 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9796:IL1RL2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ICT7 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9796:LOC100072254 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HAJ4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CPB1 ^@ http://purl.uniprot.org/uniprot/F6XIJ7 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9796:MMP13 ^@ http://purl.uniprot.org/uniprot/O18927 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||N-glycosylated.|||Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion (By similarity).|||Secreted|||Seems to be specific to breast carcinomas.|||The C-terminal region binds to collagen.|||The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme (By similarity).|||The proenzyme is activated by removal of the propeptide; this cleavage can be effected by other matrix metalloproteinases, such as MMP2, MMP3 and MMP14 and may involve several cleavage steps. Cleavage can also be autocatalytic, after partial maturation by another protease or after treatment with 4-aminophenylmercuric acetate (APMA) (in vitro) (By similarity).|||Tyrosine phosphorylated by PKDCC/VLK.|||extracellular matrix http://togogenome.org/gene/9796:EML4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HPF5|||http://purl.uniprot.org/uniprot/A0A3Q2I1I5 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9796:TACO1 ^@ http://purl.uniprot.org/uniprot/F7DJS0 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/9796:IL12B ^@ http://purl.uniprot.org/uniprot/Q9XSQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).|||Belongs to the IL-12B family.|||Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).|||Secreted http://togogenome.org/gene/9796:PYGL ^@ http://purl.uniprot.org/uniprot/B9A9Y7 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9796:RBP4 ^@ http://purl.uniprot.org/uniprot/Q28369 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.|||Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.|||Secreted http://togogenome.org/gene/9796:IFND1 ^@ http://purl.uniprot.org/uniprot/B6CGU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:EDNRB ^@ http://purl.uniprot.org/uniprot/F6PYK5|||http://purl.uniprot.org/uniprot/O62709 ^@ Disease Annotation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.|||Cell membrane|||Defects in EDNRB are a cause of overo lethal white syndrome (OLWS) also known as lethal white foal syndrome (LWFS). It is an inherited syndrome of foals born to American paint horse parents of the overo coat-pattern lineage. Affected foals are totally or almost totally white and die within days from complications due to intestinal aganglionosis.|||Membrane|||Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9796:PIPOX ^@ http://purl.uniprot.org/uniprot/F7DBT6 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/9796:TAS2R8 ^@ http://purl.uniprot.org/uniprot/F6XMV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9796:TOE1 ^@ http://purl.uniprot.org/uniprot/F6UV52 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9796:ARL5A ^@ http://purl.uniprot.org/uniprot/F7CEL2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9796:FOLR1 ^@ http://purl.uniprot.org/uniprot/F7DI80 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9796:IFITM5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RTH4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9796:TMEM33 ^@ http://purl.uniprot.org/uniprot/A0A9L0TPF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/9796:SCNM1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TGD7 ^@ Subcellular Location Annotation ^@ Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9796:DCPS ^@ http://purl.uniprot.org/uniprot/A0A9L0T761 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/9796:SCML1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZ52|||http://purl.uniprot.org/uniprot/A0A3Q2HBZ6|||http://purl.uniprot.org/uniprot/A0A9L0T2V2 ^@ Similarity ^@ Belongs to the SCM family. http://togogenome.org/gene/9796:ODF1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L7U0 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9796:TMEM200A ^@ http://purl.uniprot.org/uniprot/F7DA31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9796:KCNH5 ^@ http://purl.uniprot.org/uniprot/F7C714 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:C15H2orf49 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H1A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/9796:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GV63|||http://purl.uniprot.org/uniprot/A0A5F5Q3I6|||http://purl.uniprot.org/uniprot/F6RG52 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9796:DDAH1 ^@ http://purl.uniprot.org/uniprot/F6RUC6 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9796:LOC100070697 ^@ http://purl.uniprot.org/uniprot/F6SP48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ZDHHC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0ST93 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9796:LOC100068425 ^@ http://purl.uniprot.org/uniprot/F6TVP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DOLK ^@ http://purl.uniprot.org/uniprot/A0A9L0RZX8 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/9796:LOC100051301 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HT63 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:MRPL14 ^@ http://purl.uniprot.org/uniprot/A0A9L0RWP4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/9796:LOC100066391 ^@ http://purl.uniprot.org/uniprot/F7DVU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:APOO ^@ http://purl.uniprot.org/uniprot/A0A5F5PNJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:P2RX1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TES5|||http://purl.uniprot.org/uniprot/A0A9L0TFJ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9796:HTR2B ^@ http://purl.uniprot.org/uniprot/F6V714 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9796:IL1RAP ^@ http://purl.uniprot.org/uniprot/A0A9L0SNS8|||http://purl.uniprot.org/uniprot/A0A9L0TS88 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9796:ACADM ^@ http://purl.uniprot.org/uniprot/A0A3Q2H5D7|||http://purl.uniprot.org/uniprot/K9K3Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9796:PIGN ^@ http://purl.uniprot.org/uniprot/A0A5F5PEE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/9796:HOXA5 ^@ http://purl.uniprot.org/uniprot/F7DK44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9796:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/F7B222 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/9796:AP1B1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TQP3 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9796:IBSP ^@ http://purl.uniprot.org/uniprot/A0A9L0S209 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9796:KDM5C ^@ http://purl.uniprot.org/uniprot/A0A9L0RV16 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9796:NOL12 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L071 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP17 family.|||Interacts with KIAA1191.|||nucleolus http://togogenome.org/gene/9796:ADAMTS4 ^@ http://purl.uniprot.org/uniprot/A8HDQ3|||http://purl.uniprot.org/uniprot/Q95N24 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9796:REM1 ^@ http://purl.uniprot.org/uniprot/F6WP22 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9796:GRN ^@ http://purl.uniprot.org/uniprot/A0A3Q2GVQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/9796:CHML ^@ http://purl.uniprot.org/uniprot/A0A9L0S7I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/9796:SERPINA14 ^@ http://purl.uniprot.org/uniprot/D5SHI5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:MCHR1 ^@ http://purl.uniprot.org/uniprot/F7B4J6 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/9796:NFYB ^@ http://purl.uniprot.org/uniprot/F6XJX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9796:EPB42 ^@ http://purl.uniprot.org/uniprot/A0A9L0R4H8 ^@ Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family. http://togogenome.org/gene/9796:SNX11 ^@ http://purl.uniprot.org/uniprot/A0A9L0SUQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9796:KCNC4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H5M6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:GALNT4 ^@ http://purl.uniprot.org/uniprot/A0A9L0TDF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:ACMSD ^@ http://purl.uniprot.org/uniprot/A0A3Q2HMM7|||http://purl.uniprot.org/uniprot/F6PWP9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/9796:SELP ^@ http://purl.uniprot.org/uniprot/L7MSM7|||http://purl.uniprot.org/uniprot/Q5J3Q6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:PAN2 ^@ http://purl.uniprot.org/uniprot/F7BTR4 ^@ Activity Regulation|||Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. PAN2 subfamily.|||Binds 2 metal cations per subunit in the catalytic exonuclease domain.|||Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.|||Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.|||Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||P-body|||Positively regulated by the regulatory subunit PAN3.|||The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3. http://togogenome.org/gene/9796:LGMN ^@ http://purl.uniprot.org/uniprot/A0A5F5PT09 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9796:HTR1A ^@ http://purl.uniprot.org/uniprot/Q0EAB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli (By similarity).|||Heterodimer; heterodimerizes with GPER1 (By similarity). Interacts with YIF1B (By similarity).|||dendrite http://togogenome.org/gene/9796:FEZ1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TL28|||http://purl.uniprot.org/uniprot/A4UZ22 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/9796:MRPL12 ^@ http://purl.uniprot.org/uniprot/F6XAD7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/9796:TMEM176A ^@ http://purl.uniprot.org/uniprot/A0A9L0T1J7 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9796:DTNA ^@ http://purl.uniprot.org/uniprot/A0A3Q2GSU2|||http://purl.uniprot.org/uniprot/A0A3Q2H8Q0|||http://purl.uniprot.org/uniprot/A0A3Q2HE78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9796:SKAP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RA22 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9796:ATXN3 ^@ http://purl.uniprot.org/uniprot/K9K2B3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:HOXC12 ^@ http://purl.uniprot.org/uniprot/F6PXR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:FOXS1 ^@ http://purl.uniprot.org/uniprot/F7C4Y0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:BYSL ^@ http://purl.uniprot.org/uniprot/F6RNL5 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9796:KCNJ5 ^@ http://purl.uniprot.org/uniprot/F6RSN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.|||Membrane http://togogenome.org/gene/9796:ACSS2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S247|||http://purl.uniprot.org/uniprot/A0A9L0SP29 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9796:GSPT2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q1J0 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/9796:WNT8B ^@ http://purl.uniprot.org/uniprot/A0A9L0RAJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9796:BCDIN3D ^@ http://purl.uniprot.org/uniprot/F6WC50 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9796:CDC25C ^@ http://purl.uniprot.org/uniprot/A0A5F5PPX2|||http://purl.uniprot.org/uniprot/A0A9L0R5T5 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9796:TMSB4X ^@ http://purl.uniprot.org/uniprot/P62327 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ AcSDKP is inactivated by ACE, which removes the dipeptide Lys-Pro from its C-terminus.|||Belongs to the thymosin beta family.|||Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with SERPINB1 (By similarity).|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||Potent inhibitor of bone marrow derived stem cell differentiation (By similarity). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).|||cytoskeleton http://togogenome.org/gene/9796:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RTX6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:INO80 ^@ http://purl.uniprot.org/uniprot/F6UT07 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/9796:CADM3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LSL5 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9796:FTCD ^@ http://purl.uniprot.org/uniprot/F6RXZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds and promotes bundling of vimentin filaments originating from the Golgi.|||Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.|||Golgi apparatus|||Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.|||In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.|||In the N-terminal section; belongs to the formiminotransferase family.|||centriole http://togogenome.org/gene/9796:GRIK2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TIJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9796:CYP17A1 ^@ http://purl.uniprot.org/uniprot/Q95328 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Microsome membrane|||Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity. http://togogenome.org/gene/9796:CDK4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SPA2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:SLC6A19 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I8K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9796:NR2C2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RE00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9796:SF3B1 ^@ http://purl.uniprot.org/uniprot/F6WZ50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/9796:YPEL5 ^@ http://purl.uniprot.org/uniprot/K9KBL9 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9796:MDH2 ^@ http://purl.uniprot.org/uniprot/F6TYW4 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/9796:STARD3NL ^@ http://purl.uniprot.org/uniprot/A0A3Q2HBZ4|||http://purl.uniprot.org/uniprot/A0A9L0SMU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/9796:EXOC6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HEH7 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9796:IL1F10 ^@ http://purl.uniprot.org/uniprot/F6X5M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9796:LOC100069259 ^@ http://purl.uniprot.org/uniprot/F6V0S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100050632 ^@ http://purl.uniprot.org/uniprot/A0A9L0S1F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A9L0SH45 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:CYB5R2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L6D6|||http://purl.uniprot.org/uniprot/A0A5F5PU09|||http://purl.uniprot.org/uniprot/A0A9L0TM57 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9796:ELOVL6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HE08 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/9796:IL1R1 ^@ http://purl.uniprot.org/uniprot/Q9TV71 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9796:DAO ^@ http://purl.uniprot.org/uniprot/A0A9L0RY59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9796:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A3Q2H9M5|||http://purl.uniprot.org/uniprot/A0A9L0TRT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9796:HOGA1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RSD9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/9796:NR5A2 ^@ http://purl.uniprot.org/uniprot/Q9GKL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9796:STAM ^@ http://purl.uniprot.org/uniprot/F7DIA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9796:TRIM46 ^@ http://purl.uniprot.org/uniprot/A0A5F5PQQ7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9796:GRHL3 ^@ http://purl.uniprot.org/uniprot/F6RV42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TYRP1 ^@ http://purl.uniprot.org/uniprot/F7BQT4|||http://purl.uniprot.org/uniprot/Q7PCK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9796:TAMM41 ^@ http://purl.uniprot.org/uniprot/A0A9L0TVE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:KEF40_p02 ^@ http://purl.uniprot.org/uniprot/P48657|||http://purl.uniprot.org/uniprot/Q6J6W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 6 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9796:ECSIT ^@ http://purl.uniprot.org/uniprot/A0A9L0TQ28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the ECSIT family.|||Cytoplasm|||Mitochondrion|||Nucleus http://togogenome.org/gene/9796:FSHB ^@ http://purl.uniprot.org/uniprot/K9NVU5|||http://purl.uniprot.org/uniprot/P01226 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.|||Secreted|||Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. http://togogenome.org/gene/9796:GRK6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RR65 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9796:HOXC6 ^@ http://purl.uniprot.org/uniprot/F6Y566 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PHB2 ^@ http://purl.uniprot.org/uniprot/F6XXH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:GANAB ^@ http://purl.uniprot.org/uniprot/F7C4H8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9796:PKLR ^@ http://purl.uniprot.org/uniprot/A0A9L0R191|||http://purl.uniprot.org/uniprot/F7ANK4 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9796:RIBC1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HT43|||http://purl.uniprot.org/uniprot/A0A3Q2LJM4 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9796:SLC25A31 ^@ http://purl.uniprot.org/uniprot/F7DPW3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9796:SEC22C ^@ http://purl.uniprot.org/uniprot/A0A9L0SY95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9796:PCYT1B ^@ http://purl.uniprot.org/uniprot/A0A3Q2HF87|||http://purl.uniprot.org/uniprot/A0A3Q2HJI2|||http://purl.uniprot.org/uniprot/A0A9L0SQM9 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9796:TNP2 ^@ http://purl.uniprot.org/uniprot/B3LF35 ^@ Function|||Similarity ^@ Belongs to the nuclear transition protein 2 family.|||Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. http://togogenome.org/gene/9796:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HAN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:HHIP ^@ http://purl.uniprot.org/uniprot/A0A9L0T1M8 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:PANX3 ^@ http://purl.uniprot.org/uniprot/F6TM26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9796:DNA2 ^@ http://purl.uniprot.org/uniprot/A0A9L0R9J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9796:APPL2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PVG2 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9796:KRT35 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q4K1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:KCNJ1 ^@ http://purl.uniprot.org/uniprot/F6S9A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9796:MINDY3 ^@ http://purl.uniprot.org/uniprot/F7DRK3 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9796:SRPRB ^@ http://purl.uniprot.org/uniprot/A0A3Q2ICY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:NEMP1 ^@ http://purl.uniprot.org/uniprot/K9KAN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/9796:RNMT ^@ http://purl.uniprot.org/uniprot/A0A9L0SAD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/9796:THRB ^@ http://purl.uniprot.org/uniprot/F7E341 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9796:CDH6 ^@ http://purl.uniprot.org/uniprot/F6X200 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:JUNB ^@ http://purl.uniprot.org/uniprot/F6Y5A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/9796:LOC100072752 ^@ http://purl.uniprot.org/uniprot/F6XHC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SGCG ^@ http://purl.uniprot.org/uniprot/A0A9L0RHI5|||http://purl.uniprot.org/uniprot/F6WMD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9796:KNG1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PUE2|||http://purl.uniprot.org/uniprot/F7C0D9 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/9796:LCA5 ^@ http://purl.uniprot.org/uniprot/F6TRR5 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9796:LOC100052727 ^@ http://purl.uniprot.org/uniprot/A0A9L0TDX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9796:GALNT15 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HH16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:CYP2C113 ^@ http://purl.uniprot.org/uniprot/W8W0T9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9796:CRYGS ^@ http://purl.uniprot.org/uniprot/F7DV62 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9796:LOC100063146 ^@ http://purl.uniprot.org/uniprot/F6TF07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9796:DPEP1 ^@ http://purl.uniprot.org/uniprot/F6TJM7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9796:GGH ^@ http://purl.uniprot.org/uniprot/A0A9L0RJD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/9796:IRF1 ^@ http://purl.uniprot.org/uniprot/F6PPJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9796:KPNA6 ^@ http://purl.uniprot.org/uniprot/A0A9L0TLD2 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9796:TMCC2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PU54 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9796:TNFRSF14 ^@ http://purl.uniprot.org/uniprot/Q4G265 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC106783161 ^@ http://purl.uniprot.org/uniprot/A0A9L0R4L2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:C3H4orf22 ^@ http://purl.uniprot.org/uniprot/A0A9L0S6U0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/9796:STIM1 ^@ http://purl.uniprot.org/uniprot/F6TJL6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:WWOX ^@ http://purl.uniprot.org/uniprot/A0A9L0SBS1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus|||Lysosome|||Mitochondrion http://togogenome.org/gene/9796:MED8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SR33|||http://purl.uniprot.org/uniprot/F6SFZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9796:LOC100051754 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H613 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9796:VEGFD ^@ http://purl.uniprot.org/uniprot/A0A3Q2HIS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9796:ZNF18 ^@ http://purl.uniprot.org/uniprot/A0A9L0RWA0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:KIAA1324 ^@ http://purl.uniprot.org/uniprot/A0A9L0RKQ3|||http://purl.uniprot.org/uniprot/A0A9L0SZK6|||http://purl.uniprot.org/uniprot/A0A9L0T684 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PGM2L1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RZS5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9796:TPST2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HJR3|||http://purl.uniprot.org/uniprot/A0A9L0RLZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/9796:TPH1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L971 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9796:TEKT1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RH01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9796:GPR183 ^@ http://purl.uniprot.org/uniprot/F6VPM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:CDKAL1 ^@ http://purl.uniprot.org/uniprot/F6PJ52 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9796:MTNR1A ^@ http://purl.uniprot.org/uniprot/F7CZB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9796:SMG6 ^@ http://purl.uniprot.org/uniprot/A0A9L0R1D4|||http://purl.uniprot.org/uniprot/A0A9L0SZY7 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.|||Plays a role in nonsense-mediated mRNA decay.|||The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.|||cytosol|||nucleolus|||telomere http://togogenome.org/gene/9796:LHX3 ^@ http://purl.uniprot.org/uniprot/A0A9L0TJK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:CCKAR ^@ http://purl.uniprot.org/uniprot/F7AHW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9796:SHCBP1L ^@ http://purl.uniprot.org/uniprot/F6SKW3 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9796:GNRHR ^@ http://purl.uniprot.org/uniprot/O18821 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). http://togogenome.org/gene/9796:EDC3 ^@ http://purl.uniprot.org/uniprot/F6S066 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/9796:GPR52 ^@ http://purl.uniprot.org/uniprot/A0A9L0SLI2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:LOC100072560 ^@ http://purl.uniprot.org/uniprot/F7DVL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:KRT34 ^@ http://purl.uniprot.org/uniprot/F6YSL6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:COPB1 ^@ http://purl.uniprot.org/uniprot/F6YZP7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9796:SGCD ^@ http://purl.uniprot.org/uniprot/F6TWW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9796:ERG28 ^@ http://purl.uniprot.org/uniprot/A0A9L0S2I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:MAPK1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PIW7 ^@ Subcellular Location Annotation ^@ caveola|||focal adhesion http://togogenome.org/gene/9796:PLPPR1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SE60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9796:LOC100070570 ^@ http://purl.uniprot.org/uniprot/A0A9L0SPL4 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9796:FAM126B ^@ http://purl.uniprot.org/uniprot/A0A9L0S6G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9796:PLA2G4E ^@ http://purl.uniprot.org/uniprot/A0A9L0TV02 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9796:HACD4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HZS3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:ARRDC3 ^@ http://purl.uniprot.org/uniprot/F7BVB7 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9796:LOC100064612 ^@ http://purl.uniprot.org/uniprot/A0A7R8C3G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:IFNA1 ^@ http://purl.uniprot.org/uniprot/P05005 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.|||Secreted http://togogenome.org/gene/9796:UBE4B ^@ http://purl.uniprot.org/uniprot/F6RQ49 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9796:LOC100058512 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4Z1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PGFS ^@ http://purl.uniprot.org/uniprot/Q6W8P9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the aldo/keto reductase family.|||Cytoplasm|||Detected in endometrium surface epithelium (at protein level). Detected in endometrium.|||Monomer.|||NADP-dependent oxidoreductase involved in steroid metabolism. May act on various hydroxysteroids. http://togogenome.org/gene/9796:LGALS3BP ^@ http://purl.uniprot.org/uniprot/A0A3Q2I8H8 ^@ Function|||Subcellular Location Annotation ^@ Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.|||extracellular matrix http://togogenome.org/gene/9796:ARHGDIB ^@ http://purl.uniprot.org/uniprot/K9KB03 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9796:GRPR ^@ http://purl.uniprot.org/uniprot/F7CVR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100058582 ^@ http://purl.uniprot.org/uniprot/F6PPX7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9796:SLC7A3 ^@ http://purl.uniprot.org/uniprot/F6VJA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:STRN3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HFF7|||http://purl.uniprot.org/uniprot/A0A3Q2LAB0|||http://purl.uniprot.org/uniprot/F7D0E4|||http://purl.uniprot.org/uniprot/F7DGQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/9796:LOC100062825 ^@ http://purl.uniprot.org/uniprot/A0A5F5PRK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PPP1R1C ^@ http://purl.uniprot.org/uniprot/F6YZP0 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/9796:TEFM ^@ http://purl.uniprot.org/uniprot/A0A9L0QXW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TEFM family.|||Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.|||mitochondrion nucleoid http://togogenome.org/gene/9796:EVA1A ^@ http://purl.uniprot.org/uniprot/A0A3Q2HM07 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9796:LOC100061656 ^@ http://purl.uniprot.org/uniprot/F6QAD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/9796:IL6 ^@ http://purl.uniprot.org/uniprot/Q95181 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).|||Belongs to the IL-6 superfamily.|||Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.|||Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.|||IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).|||Secreted http://togogenome.org/gene/9796:YIF1A ^@ http://purl.uniprot.org/uniprot/A8R5L7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9796:ZNF215 ^@ http://purl.uniprot.org/uniprot/A0A9L0RD44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100068835 ^@ http://purl.uniprot.org/uniprot/A0A9L0TQL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TFAP2A ^@ http://purl.uniprot.org/uniprot/F6RW70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AP-2 family.|||Nucleus http://togogenome.org/gene/9796:GTF2B ^@ http://purl.uniprot.org/uniprot/F6PJP4 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/9796:SCMH1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H766 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9796:POLA2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SC49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/9796:GRIA3 ^@ http://purl.uniprot.org/uniprot/F6Q8I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9796:TEC ^@ http://purl.uniprot.org/uniprot/F6QY61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:KIT ^@ http://purl.uniprot.org/uniprot/A8E0G5|||http://purl.uniprot.org/uniprot/F5HS93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:ASZ1 ^@ http://purl.uniprot.org/uniprot/Q2QLA4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). http://togogenome.org/gene/9796:ATG9B ^@ http://purl.uniprot.org/uniprot/F7BL31 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9796:CPNE8 ^@ http://purl.uniprot.org/uniprot/F6TDX5 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9796:LOC100053499 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HBF8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:AMIGO2 ^@ http://purl.uniprot.org/uniprot/F7CBZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9796:SRP54 ^@ http://purl.uniprot.org/uniprot/A0A9L0R9X2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/9796:HDAC7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HYC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9796:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A3Q2I2H8 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9796:MGAT5 ^@ http://purl.uniprot.org/uniprot/A0A9L0TMG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/9796:LOC100069426 ^@ http://purl.uniprot.org/uniprot/F6XNV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RTW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9796:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A9L0S8G6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9796:RPL23 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LDJ2 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9796:CNMD ^@ http://purl.uniprot.org/uniprot/F7D9D8 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9796:GAB3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0V2|||http://purl.uniprot.org/uniprot/F6TIU8 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9796:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0Q5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:LOC100065786 ^@ http://purl.uniprot.org/uniprot/A0A9L0TKZ7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9796:USP9X ^@ http://purl.uniprot.org/uniprot/F7CE06 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9796:LOC102148609 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q2N8 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9796:SFTPD ^@ http://purl.uniprot.org/uniprot/A0A9L0SW71 ^@ Similarity|||Subunit ^@ Belongs to the SFTPD family.|||Oligomeric complex of 4 set of homotrimers. http://togogenome.org/gene/9796:SLC30A4 ^@ http://purl.uniprot.org/uniprot/F7BXJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9796:CD28 ^@ http://purl.uniprot.org/uniprot/A7LBQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ZIC3 ^@ http://purl.uniprot.org/uniprot/F7BJ75 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9796:LOC100049926 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HU76 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:CHAC2 ^@ http://purl.uniprot.org/uniprot/F7DH59 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9796:TGFBR2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KYD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane|||Membrane raft http://togogenome.org/gene/9796:ZCCHC4 ^@ http://purl.uniprot.org/uniprot/A0A9L0RYJ5|||http://purl.uniprot.org/uniprot/A0A9L0SD95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9796:MITF ^@ http://purl.uniprot.org/uniprot/A0A3Q2I515 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9796:DCN ^@ http://purl.uniprot.org/uniprot/O46542 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).|||May affect the rate of fibrils formation.|||Secreted|||The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.|||extracellular matrix http://togogenome.org/gene/9796:LOC106781326 ^@ http://purl.uniprot.org/uniprot/F7CZP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9796:YBEY ^@ http://purl.uniprot.org/uniprot/F7A2E6 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/9796:RNF152 ^@ http://purl.uniprot.org/uniprot/A0A9L0TRH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9796:MARVELD2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GVY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9796:KHDRBS2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TK03 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/9796:SLC24A2 ^@ http://purl.uniprot.org/uniprot/F7E0G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9796:LOC100055814 ^@ http://purl.uniprot.org/uniprot/A0A5F5PUN0 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9796:APTX ^@ http://purl.uniprot.org/uniprot/A0A3Q2L6G4 ^@ Subcellular Location Annotation ^@ nucleolus|||nucleoplasm http://togogenome.org/gene/9796:LOC100050719 ^@ http://purl.uniprot.org/uniprot/F6UGQ4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9796:HTR3A ^@ http://purl.uniprot.org/uniprot/F7D7A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:CYP2F1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H5D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Membrane|||Microsome membrane http://togogenome.org/gene/9796:LOC100053065 ^@ http://purl.uniprot.org/uniprot/F6Y7V5 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:LOC100064281 ^@ http://purl.uniprot.org/uniprot/F7D7N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9796:HSPA13 ^@ http://purl.uniprot.org/uniprot/F6Z4B4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/9796:GPHB5 ^@ http://purl.uniprot.org/uniprot/F6S8D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9796:NR1H3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RM32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9796:KEF40_p12 ^@ http://purl.uniprot.org/uniprot/G4RIT2|||http://purl.uniprot.org/uniprot/P48653 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 2 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (By similarity).|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:HOXB13 ^@ http://purl.uniprot.org/uniprot/F6ZTG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9796:GADL1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GYW5|||http://purl.uniprot.org/uniprot/A0A9L0SHE2 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9796:BCOR ^@ http://purl.uniprot.org/uniprot/A0A9L0SA99 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9796:NDUFA12 ^@ http://purl.uniprot.org/uniprot/F6UTA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:LOC100072221 ^@ http://purl.uniprot.org/uniprot/F7DFI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CTBS ^@ http://purl.uniprot.org/uniprot/F6TSN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family.|||Lysosome http://togogenome.org/gene/9796:FGFR2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GS33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100069689 ^@ http://purl.uniprot.org/uniprot/F6RJM3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CCR2 ^@ http://purl.uniprot.org/uniprot/B3SPX1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:PROK1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HU93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9796:ADCY4 ^@ http://purl.uniprot.org/uniprot/F6ZH58 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9796:GATC ^@ http://purl.uniprot.org/uniprot/F7C1D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9796:FIBIN ^@ http://purl.uniprot.org/uniprot/A4UZ23 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers (By similarity).|||Secreted http://togogenome.org/gene/9796:ST6GALNAC1 ^@ http://purl.uniprot.org/uniprot/F6S9S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9796:IL33 ^@ http://purl.uniprot.org/uniprot/A0A5F5PWL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9796:AOX4 ^@ http://purl.uniprot.org/uniprot/M1ZMK5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9796:LOC100147577 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GTS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CPA4 ^@ http://purl.uniprot.org/uniprot/F7BP09 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9796:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SPW0 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ITGA10 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H7P4|||http://purl.uniprot.org/uniprot/A0A9L0T1H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9796:PLSCR1 ^@ http://purl.uniprot.org/uniprot/F6S4G6 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9796:PTGER4 ^@ http://purl.uniprot.org/uniprot/F6ZUH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9796:CLTRN ^@ http://purl.uniprot.org/uniprot/A0A9L0TBQ1|||http://purl.uniprot.org/uniprot/A0A9L0TEC5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:KLK1E2 ^@ http://purl.uniprot.org/uniprot/Q6H321 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the peptidase S1 family. Kallikrein subfamily.|||Detected in prostate and semen.|||Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.|||Secreted http://togogenome.org/gene/9796:ZNF263 ^@ http://purl.uniprot.org/uniprot/F6YG67 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:VWF ^@ http://purl.uniprot.org/uniprot/A0A061DBP6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.|||Multimeric. Interacts with F8.|||Secreted|||extracellular matrix http://togogenome.org/gene/9796:SMC3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HBC4|||http://purl.uniprot.org/uniprot/K9KCG5|||http://purl.uniprot.org/uniprot/L7MRK9|||http://purl.uniprot.org/uniprot/L7MS50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Chromosome|||Nucleus|||centromere http://togogenome.org/gene/9796:GPR37 ^@ http://purl.uniprot.org/uniprot/F6WAE2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:ENPP2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HYR4|||http://purl.uniprot.org/uniprot/A0A9L0TF73|||http://purl.uniprot.org/uniprot/F6Z7T9|||http://purl.uniprot.org/uniprot/F6Z7X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/9796:HGD ^@ http://purl.uniprot.org/uniprot/A0A3Q2H2J4 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/9796:ACE2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TPT7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/9796:LOC100070856 ^@ http://purl.uniprot.org/uniprot/F7A9K0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DSG3 ^@ http://purl.uniprot.org/uniprot/F6ZT82 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9796:ROS1 ^@ http://purl.uniprot.org/uniprot/F6XJD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9796:SLC5A1 ^@ http://purl.uniprot.org/uniprot/Q9BDF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:IGFBP1 ^@ http://purl.uniprot.org/uniprot/F7DMX6 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds equally well IGF1 and IGF2.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:ITGAX ^@ http://purl.uniprot.org/uniprot/B0F6U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9796:LOC100053665 ^@ http://purl.uniprot.org/uniprot/F6UTE8 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:INHBC ^@ http://purl.uniprot.org/uniprot/F7DPX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9796:GABPA ^@ http://purl.uniprot.org/uniprot/F7B0D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:CFAP126 ^@ http://purl.uniprot.org/uniprot/A0A9L0STD0 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9796:ACTRT1 ^@ http://purl.uniprot.org/uniprot/F6WN44 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:LOC100050100 ^@ http://purl.uniprot.org/uniprot/F7CQ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9796:TAF8 ^@ http://purl.uniprot.org/uniprot/A0A9L0R7Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/9796:RHAG ^@ http://purl.uniprot.org/uniprot/F6T1H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9796:FGD3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SU58|||http://purl.uniprot.org/uniprot/F6V8R8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9796:UBA2 ^@ http://purl.uniprot.org/uniprot/F7CZK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-activating E1 family.|||Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.|||Nucleus|||The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. http://togogenome.org/gene/9796:TASP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LTZ3 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/9796:HSPH1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PQ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm http://togogenome.org/gene/9796:RPL9 ^@ http://purl.uniprot.org/uniprot/F6YIK2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/9796:NDUFA5 ^@ http://purl.uniprot.org/uniprot/K9KEN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:LOC100056283 ^@ http://purl.uniprot.org/uniprot/F6TCR6 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9796:LOC100050685 ^@ http://purl.uniprot.org/uniprot/A0A9L0SFT5 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9796:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A9L0RVW5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:A1CF ^@ http://purl.uniprot.org/uniprot/F6SEL6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:KCNJ11 ^@ http://purl.uniprot.org/uniprot/F6TM38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/9796:CITED1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S0L6|||http://purl.uniprot.org/uniprot/A0A9L0SRZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/9796:BLVRA ^@ http://purl.uniprot.org/uniprot/K9K3J5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.|||Monomer.|||Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.|||cytosol http://togogenome.org/gene/9796:DUSP26 ^@ http://purl.uniprot.org/uniprot/F7DRR6 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9796:CAPRIN1 ^@ http://purl.uniprot.org/uniprot/F7E030 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/9796:ABCB1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KSZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:SPATA20 ^@ http://purl.uniprot.org/uniprot/F6W2S8 ^@ Function|||Subcellular Location Annotation ^@ May play a role in fertility regulation.|||Secreted http://togogenome.org/gene/9796:PIK3C3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HDM7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9796:LOC100050174 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HV48 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9796:LOC100629951 ^@ http://purl.uniprot.org/uniprot/B3GDZ0|||http://purl.uniprot.org/uniprot/P05003 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.|||Secreted http://togogenome.org/gene/9796:PRRT1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TM27 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9796:EQUCABV1R912 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:DRGX ^@ http://purl.uniprot.org/uniprot/F6UMR3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:EIF1AD ^@ http://purl.uniprot.org/uniprot/A0A9L0S124 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation. http://togogenome.org/gene/9796:LOC100063252 ^@ http://purl.uniprot.org/uniprot/A0A9L0TP02 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Inflammasome http://togogenome.org/gene/9796:CACNB3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HUK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9796:EDNRA ^@ http://purl.uniprot.org/uniprot/A0A3Q2HSI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9796:ETV3L ^@ http://purl.uniprot.org/uniprot/F6WKX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:BTK ^@ http://purl.uniprot.org/uniprot/A0A9L0R1J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:DCK ^@ http://purl.uniprot.org/uniprot/A0A9L0RAP3 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9796:GTF2H3 ^@ http://purl.uniprot.org/uniprot/A0A9L0S6U6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/9796:DCAF13 ^@ http://purl.uniprot.org/uniprot/F6ZBF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/9796:DVL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RN45 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/9796:PDE6A ^@ http://purl.uniprot.org/uniprot/F6XG29 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9796:MRPL46 ^@ http://purl.uniprot.org/uniprot/A0A9L0S493 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/9796:CNTNAP5 ^@ http://purl.uniprot.org/uniprot/F6QSR8 ^@ Caution|||Similarity ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ENOPH1 ^@ http://purl.uniprot.org/uniprot/F7D9G5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9796:TMEM45B ^@ http://purl.uniprot.org/uniprot/F7D765 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9796:TLR4 ^@ http://purl.uniprot.org/uniprot/Q9MYW3 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Toll-like receptor family.|||Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with MAP3K21; this interaction leads to negative regulation of TLR4 signaling. Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR6. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Interacts with TICAM1 in response to LPS in a WDFY1-dependent manner. Interacts with WDFY1 in response to LPS. Interacts with SMPDL3B. Interacts with CEACAM1; upon lipopolysaccharide stimulation, forms a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Interacts with RFTN1; the interaction occurs in response to lipopolysaccharide stimulation. Interacts with SCIMP; the interaction occurs in response to lipopolysaccharide stimulation and is enhanced by phosphorylation of SCIMP by LYN (By similarity). This interaction facilitates the phosphorylation of TLR4 by LYN which elicits a selective cytokine response in macrophages (By similarity). Interacts with TRAF3IP3 (By similarity). Interacts with TREM1; this interaction enhances TLR4-mediated inflammatory response (By similarity).|||Cell membrane|||Early endosome|||In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.|||Phosphorylated on tyrosine residues by LYN after binding lipopolysaccharide.|||The TIR domain mediates interaction with NOX4.|||Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade. In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86. Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway. In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner.|||ruffle http://togogenome.org/gene/9796:PCSK1 ^@ http://purl.uniprot.org/uniprot/F6TCF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9796:SLC2A3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HM94 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Cell projection|||Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Perikaryon|||Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm. http://togogenome.org/gene/9796:LOC102149981 ^@ http://purl.uniprot.org/uniprot/F6T3P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TSEN2 ^@ http://purl.uniprot.org/uniprot/F6QV95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/9796:PSEN1 ^@ http://purl.uniprot.org/uniprot/F6SAM1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/9796:CMTM2 ^@ http://purl.uniprot.org/uniprot/F6TWG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:MED30 ^@ http://purl.uniprot.org/uniprot/A0A9L0SP30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9796:LOC100052568 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ID58 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:IDO2 ^@ http://purl.uniprot.org/uniprot/F6WMA5 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/9796:LOC100054696 ^@ http://purl.uniprot.org/uniprot/F7DWL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CES5A ^@ http://purl.uniprot.org/uniprot/F7C7A8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9796:PLA2G4F ^@ http://purl.uniprot.org/uniprot/F6S266 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9796:MYLK4 ^@ http://purl.uniprot.org/uniprot/A0A9L0S9I5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:NR4A2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H5S3|||http://purl.uniprot.org/uniprot/F6ZRL4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9796:PTH ^@ http://purl.uniprot.org/uniprot/Q27IM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Interacts with PTH1R (via N-terminal extracellular domain).|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).|||Secreted http://togogenome.org/gene/9796:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWP4|||http://purl.uniprot.org/uniprot/A0A9L0TF46|||http://purl.uniprot.org/uniprot/A0A9L0TLK9 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9796:SDHC ^@ http://purl.uniprot.org/uniprot/A0A5F5PEQ5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9796:INSIG2 ^@ http://purl.uniprot.org/uniprot/F6V608 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9796:CCR3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RDX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:C27H4orf47 ^@ http://purl.uniprot.org/uniprot/A0A9L0TL97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/9796:ATP5PO ^@ http://purl.uniprot.org/uniprot/F6WLI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:FGR ^@ http://purl.uniprot.org/uniprot/F7CK20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:MTIF3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T5V5 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/9796:TMEM19 ^@ http://purl.uniprot.org/uniprot/A0A9L0RSM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/9796:PDCL3 ^@ http://purl.uniprot.org/uniprot/L7MRB2 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9796:TRHR ^@ http://purl.uniprot.org/uniprot/F6WCI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9796:CFLAR ^@ http://purl.uniprot.org/uniprot/F6RFJ8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9796:LOC100054056 ^@ http://purl.uniprot.org/uniprot/F7CX23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NDUFV3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T480 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/9796:SLC25A42 ^@ http://purl.uniprot.org/uniprot/A0A9L0TMW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:POLR2K ^@ http://purl.uniprot.org/uniprot/F6WFR2 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9796:COPS8 ^@ http://purl.uniprot.org/uniprot/A0A9L0TJ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:GPM6A ^@ http://purl.uniprot.org/uniprot/F6WJF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9796:LOC100070611 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HM82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SPATA18 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWW7|||http://purl.uniprot.org/uniprot/A0A5F5PRS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIEAP family.|||Cytoplasm|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9796:LOC100629705 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I1J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CYP3A94 ^@ http://purl.uniprot.org/uniprot/D7GB57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:KIF27 ^@ http://purl.uniprot.org/uniprot/F6S597|||http://purl.uniprot.org/uniprot/F6S5U9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9796:CYP3A89 ^@ http://purl.uniprot.org/uniprot/A7LGW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:FGF5 ^@ http://purl.uniprot.org/uniprot/A0A7U3JWA7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:MAOB ^@ http://purl.uniprot.org/uniprot/Q5NU31 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flavin monoamine oxidase family.|||Mitochondrion outer membrane|||Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer. http://togogenome.org/gene/9796:LOC100065777 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HBX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:SUPV3L1 ^@ http://purl.uniprot.org/uniprot/F6YJ07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/9796:CLRN3 ^@ http://purl.uniprot.org/uniprot/F7BXA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9796:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T4R4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9796:SNX10 ^@ http://purl.uniprot.org/uniprot/F7AKE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9796:SLC10A1 ^@ http://purl.uniprot.org/uniprot/F7CX89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9796:LOC100629654 ^@ http://purl.uniprot.org/uniprot/A0A9L0RN32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:C14H5orf24 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LG91 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9796:PRAF2 ^@ http://purl.uniprot.org/uniprot/F7DXZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9796:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LDY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9796:LOC100059149 ^@ http://purl.uniprot.org/uniprot/F6X3Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9796:NODAL ^@ http://purl.uniprot.org/uniprot/A0A9L0SJ47 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9796:PON3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RNJ9 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/9796:CNR2 ^@ http://purl.uniprot.org/uniprot/F7CUS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/F7DMU4 ^@ Caution|||Function|||Subunit ^@ Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC100072227 ^@ http://purl.uniprot.org/uniprot/F7DEG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NSDHL ^@ http://purl.uniprot.org/uniprot/A0A9R1SCH4|||http://purl.uniprot.org/uniprot/F6V9H5 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9796:EMP1 ^@ http://purl.uniprot.org/uniprot/F6PZZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9796:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GUA6|||http://purl.uniprot.org/uniprot/A0A3Q2KU34|||http://purl.uniprot.org/uniprot/K9K449 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9796:CKM ^@ http://purl.uniprot.org/uniprot/F7BR99 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9796:RIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PW92|||http://purl.uniprot.org/uniprot/A0A9L0SLX1 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/9796:LOC100065612 ^@ http://purl.uniprot.org/uniprot/F7BH81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/9796:CEP63 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IDM3 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/9796:LOC100061127 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GUZ4 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9796:GPR34 ^@ http://purl.uniprot.org/uniprot/F6X145 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Orphan receptor. http://togogenome.org/gene/9796:PRAME ^@ http://purl.uniprot.org/uniprot/A0A3Q2IGS7 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9796:TIMM8B ^@ http://purl.uniprot.org/uniprot/F7C619 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9796:CD5L ^@ http://purl.uniprot.org/uniprot/A0A9L0SKI8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/F7D4L1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9796:SLC25A40 ^@ http://purl.uniprot.org/uniprot/A0A9L0R9B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:ART3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H2W7 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9796:NDEL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T8X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/9796:AGPAT3 ^@ http://purl.uniprot.org/uniprot/F6UFK4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9796:MFAP1 ^@ http://purl.uniprot.org/uniprot/F7BNW9 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/9796:SEC61B ^@ http://purl.uniprot.org/uniprot/F6RA60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/9796:SULF1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4X4|||http://purl.uniprot.org/uniprot/F6PP52 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9796:LOC100055688 ^@ http://purl.uniprot.org/uniprot/F6XXL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:IL13 ^@ http://purl.uniprot.org/uniprot/B6C802 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-4/IL-13 family.|||Interacts with IL13RA2.|||Secreted http://togogenome.org/gene/9796:ZNF174 ^@ http://purl.uniprot.org/uniprot/A0A5F5PZK1|||http://purl.uniprot.org/uniprot/F6T5P3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:GPR171 ^@ http://purl.uniprot.org/uniprot/F6VN40 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:LOC100064329 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L2I1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SLC46A2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KS56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:S100Z ^@ http://purl.uniprot.org/uniprot/F7CVX9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9796:LOC100064182 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KYF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100071738 ^@ http://purl.uniprot.org/uniprot/F7B6R6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SEPT9 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GVW1|||http://purl.uniprot.org/uniprot/A0A5F5Q1G7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/9796:TPH2 ^@ http://purl.uniprot.org/uniprot/Q0EAB8 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9796:LOC100061689 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LGT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:FEN1 ^@ http://purl.uniprot.org/uniprot/F6RSE3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9796:FMC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RFI0 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/9796:JAK2 ^@ http://purl.uniprot.org/uniprot/A0A9L0T0U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system|||Nucleus http://togogenome.org/gene/9796:STXBP5L ^@ http://purl.uniprot.org/uniprot/A0A3Q2L2N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9796:DDX4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KY57 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9796:ATP4B ^@ http://purl.uniprot.org/uniprot/F7E4M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9796:GORAB ^@ http://purl.uniprot.org/uniprot/A0A9L0THA0 ^@ Similarity ^@ Belongs to the GORAB family. http://togogenome.org/gene/9796:CACNB2 ^@ http://purl.uniprot.org/uniprot/F7CPA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/9796:PURG ^@ http://purl.uniprot.org/uniprot/A0A9L0T5G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/9796:ARMCX3 ^@ http://purl.uniprot.org/uniprot/F6TMP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9796:ZC3H12A ^@ http://purl.uniprot.org/uniprot/F6YJG4 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9796:NCK2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H3S9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9796:SMAD5 ^@ http://purl.uniprot.org/uniprot/F7A120 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:METTL6 ^@ http://purl.uniprot.org/uniprot/F6QR92 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9796:UBE2L6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RMT6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9796:MED23 ^@ http://purl.uniprot.org/uniprot/F6SIM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/9796:PSMB9 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GVY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:TMTC2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RAA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9796:PRKAR1A ^@ http://purl.uniprot.org/uniprot/K9K227 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:P2RY11 ^@ http://purl.uniprot.org/uniprot/A0A9L0RI75 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:LYZL6 ^@ http://purl.uniprot.org/uniprot/A0A077SA08 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9796:LOC100066690 ^@ http://purl.uniprot.org/uniprot/F6WNB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ACTG2 ^@ http://purl.uniprot.org/uniprot/F6Z8K0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:PAH ^@ http://purl.uniprot.org/uniprot/A0A5F5PW17 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9796:TSPAN12 ^@ http://purl.uniprot.org/uniprot/A0A9L0S395 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:TMCC3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LPY1 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9796:LOC100056062 ^@ http://purl.uniprot.org/uniprot/Q38RB8 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:CDK7 ^@ http://purl.uniprot.org/uniprot/K9K3U4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9796:CDH15 ^@ http://purl.uniprot.org/uniprot/F6WEI6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:CLPS ^@ http://purl.uniprot.org/uniprot/F6SDT9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/9796:HOXA10 ^@ http://purl.uniprot.org/uniprot/F6RVJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9796:LOC100071565 ^@ http://purl.uniprot.org/uniprot/A0A5F5PZF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PLPPR4 ^@ http://purl.uniprot.org/uniprot/F7B3C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9796:MYO10 ^@ http://purl.uniprot.org/uniprot/A0A9L0RDZ1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9796:GPR65 ^@ http://purl.uniprot.org/uniprot/F6V2Q6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:PSMB3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RCS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:SLC6A1 ^@ http://purl.uniprot.org/uniprot/F6Z3A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9796:LOC100054567 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4N9 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9796:CHRNB1 ^@ http://purl.uniprot.org/uniprot/F6SLE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:APP ^@ http://purl.uniprot.org/uniprot/A0A3Q2HIF9|||http://purl.uniprot.org/uniprot/A0A5F5PX07|||http://purl.uniprot.org/uniprot/F6XKR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle|||Early endosome|||Endosome|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Golgi apparatus|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).|||Nucleus|||Perikaryon|||Secreted|||The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.|||Vesicle|||clathrin-coated pit|||growth cone http://togogenome.org/gene/9796:LHX4 ^@ http://purl.uniprot.org/uniprot/F7C7F3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:NDUFS7 ^@ http://purl.uniprot.org/uniprot/F7D489 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/9796:RBM5 ^@ http://purl.uniprot.org/uniprot/F6WC92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/9796:CDC42EP4 ^@ http://purl.uniprot.org/uniprot/F6U0W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9796:SULT1E1 ^@ http://purl.uniprot.org/uniprot/Q0NXS2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:LOC100072302 ^@ http://purl.uniprot.org/uniprot/F7DGJ8 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/9796:CNR1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R3E4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.|||Interacts (via C-terminus) with CNRIP1.|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/9796:IRX6 ^@ http://purl.uniprot.org/uniprot/F7CUY6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100630758 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KSW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:BCKDHA ^@ http://purl.uniprot.org/uniprot/F6REC8 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. http://togogenome.org/gene/9796:ZSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A9L0QYJ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:MPPED2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SBP1 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9796:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LMU1 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9796:THOC5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HXL2|||http://purl.uniprot.org/uniprot/A0A3Q2IAG7|||http://purl.uniprot.org/uniprot/A0A3Q2KXM0|||http://purl.uniprot.org/uniprot/F6VEX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/9796:TPPP3 ^@ http://purl.uniprot.org/uniprot/F7CMU1 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9796:LOC100068322 ^@ http://purl.uniprot.org/uniprot/A0A9L0R3Q3|||http://purl.uniprot.org/uniprot/A0A9L0TSB9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9796:ZC3HAV1 ^@ http://purl.uniprot.org/uniprot/F6S442 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9796:TES ^@ http://purl.uniprot.org/uniprot/A0A3Q2IDJ3|||http://purl.uniprot.org/uniprot/Q2QLB2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.|||The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.|||focal adhesion http://togogenome.org/gene/9796:CSN2 ^@ http://purl.uniprot.org/uniprot/Q9GKK3 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Accounts for 4% of total casein.|||Belongs to the beta-casein family.|||Important role in determination of the surface properties of the casein micelles.|||Mammary gland specific. Secreted in milk.|||Secreted|||Spontaneous deamidation of Asn-150 produces aspartate or isoaspartate.|||There are at least five different forms found in milk, with varying degrees of phosphorylation. These include form 3-P which is phosphorylated at three sites that have not been determined, this form is present in very low amounts, form 4-P which is phosphorylated at four sites, form 5-P which is phosphorylated at five sites, form 6-P which is phosphorylated at six sites, and form 7-P which is phosphorylated at seven sites. http://togogenome.org/gene/9796:PPFIBP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TAA3|||http://purl.uniprot.org/uniprot/F6T0Q7 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9796:LOC100057758 ^@ http://purl.uniprot.org/uniprot/F6S4T4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9796:DARS2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HM61|||http://purl.uniprot.org/uniprot/A0A9L0RHX0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/9796:ARSJ ^@ http://purl.uniprot.org/uniprot/A0A9L0RZL5 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9796:TUSC5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GUS7 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9796:LOC102149276 ^@ http://purl.uniprot.org/uniprot/A0A9L0TBN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9796:DIS3L ^@ http://purl.uniprot.org/uniprot/A0A9L0SPE0 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/9796:ROCK1 ^@ http://purl.uniprot.org/uniprot/F6XUQ9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by RHOA binding. Inhibited by Y-27632.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Homodimer.|||Membrane|||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. http://togogenome.org/gene/9796:CCDC86 ^@ http://purl.uniprot.org/uniprot/F6TN71 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TNR ^@ http://purl.uniprot.org/uniprot/A0A3Q2LE99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/9796:JPT2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S865 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:LOC100070801 ^@ http://purl.uniprot.org/uniprot/A0A9L0TQP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ST7 ^@ http://purl.uniprot.org/uniprot/Q2QLA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9796:NGF ^@ http://purl.uniprot.org/uniprot/F6SVV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted http://togogenome.org/gene/9796:S100G ^@ http://purl.uniprot.org/uniprot/Q865V3 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9796:GPR146 ^@ http://purl.uniprot.org/uniprot/A0A9L0S0U2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:KCNF1 ^@ http://purl.uniprot.org/uniprot/F7E016 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:YARS2 ^@ http://purl.uniprot.org/uniprot/F6ZTM2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9796:LOC100069291 ^@ http://purl.uniprot.org/uniprot/F6TVT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CD247 ^@ http://purl.uniprot.org/uniprot/F7DH49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LHX9 ^@ http://purl.uniprot.org/uniprot/A0A9L0RKW9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TSPYL4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SIY7 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9796:MEIS2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SB46|||http://purl.uniprot.org/uniprot/A0A9L0TPE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9796:EQMHCB2 ^@ http://purl.uniprot.org/uniprot/Q38RB9 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:PIGM ^@ http://purl.uniprot.org/uniprot/A0A9L0SW51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.|||Membrane http://togogenome.org/gene/9796:ELF5 ^@ http://purl.uniprot.org/uniprot/F6W442 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:NCDN ^@ http://purl.uniprot.org/uniprot/F6Q1Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/9796:FAM234A ^@ http://purl.uniprot.org/uniprot/A0A3Q2GTB2|||http://purl.uniprot.org/uniprot/F6S1Q2 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9796:METTL8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SJQ0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. METL family. http://togogenome.org/gene/9796:ZBED4 ^@ http://purl.uniprot.org/uniprot/F7D635 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:GJB5 ^@ http://purl.uniprot.org/uniprot/F6RSJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:CHST6 ^@ http://purl.uniprot.org/uniprot/A0A9L0T4N9|||http://purl.uniprot.org/uniprot/F6VXD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9796:SLC31A1 ^@ http://purl.uniprot.org/uniprot/F7DEZ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Late endosome membrane|||Membrane http://togogenome.org/gene/9796:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A9L0S019 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9796:ATG7 ^@ http://purl.uniprot.org/uniprot/A0A9L0RUJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.|||Homodimer.|||Preautophagosomal structure http://togogenome.org/gene/9796:ZSCAN16 ^@ http://purl.uniprot.org/uniprot/A0A9L0SP63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:NPPB ^@ http://purl.uniprot.org/uniprot/F6ZWP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.|||Secreted http://togogenome.org/gene/9796:NRM ^@ http://purl.uniprot.org/uniprot/F6WIG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9796:CHIT1 ^@ http://purl.uniprot.org/uniprot/B7S833 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/9796:MC3R ^@ http://purl.uniprot.org/uniprot/F6SBB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/9796:SFMBT2 ^@ http://purl.uniprot.org/uniprot/F6R1F6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100061035 ^@ http://purl.uniprot.org/uniprot/L7MRN6 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9796:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/F6SFZ8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9796:THPO ^@ http://purl.uniprot.org/uniprot/F7BPK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/9796:BET1 ^@ http://purl.uniprot.org/uniprot/A0A9R1SB33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:AQP9 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I697|||http://purl.uniprot.org/uniprot/A0A5F5PX63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:ITGB6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HZL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||Recycling endosome|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9796:NUMB ^@ http://purl.uniprot.org/uniprot/A0A5F5PK46|||http://purl.uniprot.org/uniprot/F6YXJ9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/9796:LOC100055645 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LSD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PGBD1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TRC7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100059239 ^@ http://purl.uniprot.org/uniprot/A0A9L0R7H5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:LOC100070889 ^@ http://purl.uniprot.org/uniprot/F6WUY1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I9E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9796:ATP6V1G2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I006 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9796:GDF3 ^@ http://purl.uniprot.org/uniprot/F6YWM3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9796:CWC15 ^@ http://purl.uniprot.org/uniprot/K9KFW3 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9796:MVB12A ^@ http://purl.uniprot.org/uniprot/F6PZ21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9796:PCSK5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LAW7|||http://purl.uniprot.org/uniprot/F6VT99 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9796:GPR180 ^@ http://purl.uniprot.org/uniprot/A0A9L0RRX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ACKR3 ^@ http://purl.uniprot.org/uniprot/F7D7T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:SLC7A2 ^@ http://purl.uniprot.org/uniprot/A0A9L0R557 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:SKP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0QZH7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit.|||Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.|||The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. http://togogenome.org/gene/9796:FOXP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZ26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:C1R ^@ http://purl.uniprot.org/uniprot/A0A9L0SLY6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:GPRIN3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T7S1 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/9796:NCF2 ^@ http://purl.uniprot.org/uniprot/F6T8Y6 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9796:ZNF330 ^@ http://purl.uniprot.org/uniprot/F7DJQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||centromere|||nucleolus http://togogenome.org/gene/9796:RNASE4 ^@ http://purl.uniprot.org/uniprot/W0UVF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9796:TRHDE ^@ http://purl.uniprot.org/uniprot/F6PTN0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Membrane http://togogenome.org/gene/9796:LOC100072621 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0K2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SEMA3F ^@ http://purl.uniprot.org/uniprot/A0A3Q2IK27 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:PSMC3IP ^@ http://purl.uniprot.org/uniprot/A0A9L0R5Y2|||http://purl.uniprot.org/uniprot/F7BQN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/9796:IDUA ^@ http://purl.uniprot.org/uniprot/A0A3Q2HYE0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 39 family. http://togogenome.org/gene/9796:SDR42E1 ^@ http://purl.uniprot.org/uniprot/F7B719 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9796:ITGB3 ^@ http://purl.uniprot.org/uniprot/Q52MQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||Recycling endosome|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9796:LOC100058587 ^@ http://purl.uniprot.org/uniprot/A0A9L0RS22 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:GRP ^@ http://purl.uniprot.org/uniprot/F7DYM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||neuron projection http://togogenome.org/gene/9796:ELP5 ^@ http://purl.uniprot.org/uniprot/A0A9L0T2A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:FRAS1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TG23 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9796:LOC100630300 ^@ http://purl.uniprot.org/uniprot/F6VYF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TSFM ^@ http://purl.uniprot.org/uniprot/A0A9L0RM92|||http://purl.uniprot.org/uniprot/F6QE86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/9796:LYG2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SQ45 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9796:PIP4P2 ^@ http://purl.uniprot.org/uniprot/A0A9L0R9A8 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9796:GBE1 ^@ http://purl.uniprot.org/uniprot/Q6EAS5 ^@ Disease Annotation|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.|||Binds its carbohydrate substrate close to the active site, but also via regions close to the N-terminus; this may result in increased affinity and therefore increased catalytic efficiency.|||Defects in GBE1 are the cause of glycogen storage disease IV (GSD-IV). GSD-IV is recessive fatal fetal and neonatal disease in American Quarter horses.|||Monomer.|||Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule. http://togogenome.org/gene/9796:CD3E ^@ http://purl.uniprot.org/uniprot/A0A9L0RAV5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:CAV1 ^@ http://purl.uniprot.org/uniprot/Q2QLB0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity).|||May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).|||Membrane raft|||Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.|||Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.|||caveola http://togogenome.org/gene/9796:AIF1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PSN1 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9796:LOC100068519 ^@ http://purl.uniprot.org/uniprot/F6W803 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC102148134 ^@ http://purl.uniprot.org/uniprot/A0A9L0S3M4 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9796:UBE2H ^@ http://purl.uniprot.org/uniprot/A0A3Q2I9D8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9796:RNASE12 ^@ http://purl.uniprot.org/uniprot/F6TMR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9796:NOX4 ^@ http://purl.uniprot.org/uniprot/A0A5F5PZU6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ATP8B4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0I9|||http://purl.uniprot.org/uniprot/A0A9L0TJK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9796:KCNAB3 ^@ http://purl.uniprot.org/uniprot/F7BC63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/9796:DIAPH3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HP41 ^@ Similarity ^@ Belongs to the formin homology family. Diaphanous subfamily. http://togogenome.org/gene/9796:CRISP1 ^@ http://purl.uniprot.org/uniprot/A0A9R1SSQ2|||http://purl.uniprot.org/uniprot/Q8MHX2 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:CCR9 ^@ http://purl.uniprot.org/uniprot/F6X7N4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/F6ZXT0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/9796:RNASE9 ^@ http://purl.uniprot.org/uniprot/W0UV08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9796:GRM3 ^@ http://purl.uniprot.org/uniprot/F6T9I4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/9796:GCG ^@ http://purl.uniprot.org/uniprot/F7ABP1 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9796:KCNJ10 ^@ http://purl.uniprot.org/uniprot/A0A9L0RYZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9796:FAS ^@ http://purl.uniprot.org/uniprot/A0A9L0TB11 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/9796:AHCYL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S9T2 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9796:HK1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GXD3|||http://purl.uniprot.org/uniprot/F7BA85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9796:NMT1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I9P9 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/9796:PSMF1 ^@ http://purl.uniprot.org/uniprot/F6YY33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/9796:EXOSC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SI62 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:LOC100063322 ^@ http://purl.uniprot.org/uniprot/A0A9L0R236 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:GATA2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L499 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:ITGB1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IDL5|||http://purl.uniprot.org/uniprot/A0A9L0TG92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||Recycling endosome|||focal adhesion|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/9796:SLC22A4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SBE3 ^@ Subcellular Location Annotation|||Subunit ^@ Basal cell membrane|||Interacts with PDZK1. http://togogenome.org/gene/9796:KRT32 ^@ http://purl.uniprot.org/uniprot/A0A9L0S8F7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:SLC15A1 ^@ http://purl.uniprot.org/uniprot/F6SG69 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9796:CALB1 ^@ http://purl.uniprot.org/uniprot/F7D4N3 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. http://togogenome.org/gene/9796:GDNF ^@ http://purl.uniprot.org/uniprot/A0A3Q2LC49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/9796:ZHX3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SPB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9796:LOC100062442 ^@ http://purl.uniprot.org/uniprot/A0A5F5PQL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SIAH1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RFC0|||http://purl.uniprot.org/uniprot/A0A9L0TP90 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9796:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A9L0RNJ1 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:MEIG1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SQW1 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9796:FGF11 ^@ http://purl.uniprot.org/uniprot/A0A7U3JWB4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:GPER1 ^@ http://purl.uniprot.org/uniprot/F7DWI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:SCG5 ^@ http://purl.uniprot.org/uniprot/F6VTN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9796:LOC100072707 ^@ http://purl.uniprot.org/uniprot/W0UV07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9796:FOXJ3 ^@ http://purl.uniprot.org/uniprot/F6SCJ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:CXCL9 ^@ http://purl.uniprot.org/uniprot/B1AB89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9796:ACOD1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SRD0 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/9796:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RQ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9796:MAT2B ^@ http://purl.uniprot.org/uniprot/F6WH85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9796:LOC100072566 ^@ http://purl.uniprot.org/uniprot/F6WGB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PRNP ^@ http://purl.uniprot.org/uniprot/B5B2G8|||http://purl.uniprot.org/uniprot/B5B2H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Golgi apparatus|||Membrane http://togogenome.org/gene/9796:MED24 ^@ http://purl.uniprot.org/uniprot/A0A5F5PSS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9796:KCND1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TCA9|||http://purl.uniprot.org/uniprot/A0A9L0TPV7 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/9796:LOC100629187 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I741 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100070591 ^@ http://purl.uniprot.org/uniprot/A0A9L0TGS6 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9796:PDCD10 ^@ http://purl.uniprot.org/uniprot/L7MRY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:RBP5 ^@ http://purl.uniprot.org/uniprot/A0A9L0SDL1 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9796:GPCPD1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ICJ7 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9796:TBX15 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZR6|||http://purl.uniprot.org/uniprot/A0A9L0TMC3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9796:FAP ^@ http://purl.uniprot.org/uniprot/A0A3Q2HDD1 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9796:EZH2 ^@ http://purl.uniprot.org/uniprot/A0A9L0T738 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:C25H9orf131 ^@ http://purl.uniprot.org/uniprot/F6SGG1 ^@ Similarity ^@ Belongs to the SPATA31 family. http://togogenome.org/gene/9796:EXO5 ^@ http://purl.uniprot.org/uniprot/A0A9L0REL2 ^@ Similarity ^@ Belongs to the EXO5 family. http://togogenome.org/gene/9796:HSP90B1 ^@ http://purl.uniprot.org/uniprot/K9K2D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/9796:PFKFB2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HAX4|||http://purl.uniprot.org/uniprot/A0A9L0RRR3 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9796:ITIH4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H3F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9796:TSR1 ^@ http://purl.uniprot.org/uniprot/F6YAX8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9796:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SRB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9796:LOC100072493 ^@ http://purl.uniprot.org/uniprot/A0A9L0S4Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9796:DCP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SLI4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/9796:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A5F5PFQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/9796:CPA5 ^@ http://purl.uniprot.org/uniprot/F7E0P9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9796:LOC100066603 ^@ http://purl.uniprot.org/uniprot/F6W6T5 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9796:CAVIN2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RPJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9796:KEF40_p06 ^@ http://purl.uniprot.org/uniprot/A5JYA8|||http://purl.uniprot.org/uniprot/P48654 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM186. Interacts with TMEM242 (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9796:EIF2S1 ^@ http://purl.uniprot.org/uniprot/F7CTS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9796:DAP3 ^@ http://purl.uniprot.org/uniprot/K9KAQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/9796:DUS4L ^@ http://purl.uniprot.org/uniprot/K9K217 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/9796:STK32A ^@ http://purl.uniprot.org/uniprot/A0A9L0R3M2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:SNU13 ^@ http://purl.uniprot.org/uniprot/A0A9L0TEK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9796:CYP2C92 ^@ http://purl.uniprot.org/uniprot/A7LGW8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9796:ZBED9 ^@ http://purl.uniprot.org/uniprot/F6S057 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:IFNB1 ^@ http://purl.uniprot.org/uniprot/A0A7R8C3S1|||http://purl.uniprot.org/uniprot/P05012 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha/beta interferon family.|||Monomer.|||Secreted|||Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity). http://togogenome.org/gene/9796:PIANP ^@ http://purl.uniprot.org/uniprot/F6VYZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:SLC25A24 ^@ http://purl.uniprot.org/uniprot/F6Z4N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:S100A4 ^@ http://purl.uniprot.org/uniprot/F6UF75 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9796:POLR3C ^@ http://purl.uniprot.org/uniprot/A0A9L0SX73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9796:TFCP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0ST73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9796:GCNT1 ^@ http://purl.uniprot.org/uniprot/A8CWP2|||http://purl.uniprot.org/uniprot/F7BT86 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:NUP210L ^@ http://purl.uniprot.org/uniprot/A0A9L0S239 ^@ Similarity ^@ Belongs to the NUP210 family. http://togogenome.org/gene/9796:KCNA5 ^@ http://purl.uniprot.org/uniprot/F7DUM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:NEURL2 ^@ http://purl.uniprot.org/uniprot/F6TT21 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:LOC100052091 ^@ http://purl.uniprot.org/uniprot/F7BS18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:POP7 ^@ http://purl.uniprot.org/uniprot/F6S2S2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9796:SCRN1 ^@ http://purl.uniprot.org/uniprot/F6TY77 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9796:XRCC4 ^@ http://purl.uniprot.org/uniprot/F7DHF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/9796:MCHR2 ^@ http://purl.uniprot.org/uniprot/F6WED4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q492|||http://purl.uniprot.org/uniprot/F7A532 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/9796:LOC100061784 ^@ http://purl.uniprot.org/uniprot/A0A9L0TH32 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:LOC100069376 ^@ http://purl.uniprot.org/uniprot/F6WV11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:FOLH1B ^@ http://purl.uniprot.org/uniprot/A0A5F5PSS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:GCDH ^@ http://purl.uniprot.org/uniprot/F6S9W0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9796:NUCB2 ^@ http://purl.uniprot.org/uniprot/A0A9R1SS84 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9796:CKS1B ^@ http://purl.uniprot.org/uniprot/A0A9L0SGF7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9796:LOC100067367 ^@ http://purl.uniprot.org/uniprot/F6V5K7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RXC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9796:TBPL1 ^@ http://purl.uniprot.org/uniprot/F7DF13 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/9796:SLC2A5 ^@ http://purl.uniprot.org/uniprot/A0A452GEP2|||http://purl.uniprot.org/uniprot/Q863Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.|||Membrane|||sarcolemma http://togogenome.org/gene/9796:LOC100071445 ^@ http://purl.uniprot.org/uniprot/F6X727 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NUF2 ^@ http://purl.uniprot.org/uniprot/F6WZK8 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9796:RPLP2 ^@ http://purl.uniprot.org/uniprot/Q6X9Z5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9796:HRH1 ^@ http://purl.uniprot.org/uniprot/F6PS14|||http://purl.uniprot.org/uniprot/Q0PW07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100066640 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HZG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100064919 ^@ http://purl.uniprot.org/uniprot/A0A9L0TSL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/9796:RAD18 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IB49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD18 family.|||Nucleus http://togogenome.org/gene/9796:B4GALT3 ^@ http://purl.uniprot.org/uniprot/F6YFG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9796:PIH1D3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RWC2 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9796:LYZL4 ^@ http://purl.uniprot.org/uniprot/F6ZMI7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9796:TRIM54 ^@ http://purl.uniprot.org/uniprot/A0A9L0S136 ^@ Function|||Subcellular Location Annotation ^@ May bind and stabilize microtubules during myotubes formation.|||Z line http://togogenome.org/gene/9796:TFRC ^@ http://purl.uniprot.org/uniprot/Q2V905 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).|||Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Interacts with SH3BP4 (By similarity). Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).|||Melanosome|||Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity). http://togogenome.org/gene/9796:NLE1 ^@ http://purl.uniprot.org/uniprot/F7AQE9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9796:CRYAA ^@ http://purl.uniprot.org/uniprot/P02478 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-70 may increase chaperone activity.|||Belongs to the small heat shock protein (HSP20) family.|||Contributes to the transparency and refractive index of the lens. Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.|||Cytoplasm|||Heteromer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity). Part of a complex required for lens intermediate filament formation composed of BFSP1, BFSP2 and CRYAA (By similarity).|||Nucleus|||Undergoes age-dependent proteolytical cleavage at the C-terminus. http://togogenome.org/gene/9796:PPY ^@ http://purl.uniprot.org/uniprot/A0A5F5Q2D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9796:CEP55 ^@ http://purl.uniprot.org/uniprot/A0A9L0R8Y2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:FAH ^@ http://purl.uniprot.org/uniprot/A0A9L0TTK0 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9796:CHMP4C ^@ http://purl.uniprot.org/uniprot/F6U218 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9796:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A5F5PIP0|||http://purl.uniprot.org/uniprot/A0A9L0SG25 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T4P7 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/9796:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZQ1|||http://purl.uniprot.org/uniprot/F6RV24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule|||filopodium|||growth cone|||lamellipodium|||perinuclear region http://togogenome.org/gene/9796:LOC100069304 ^@ http://purl.uniprot.org/uniprot/F6XVK0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100065549 ^@ http://purl.uniprot.org/uniprot/F7D230 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100072007 ^@ http://purl.uniprot.org/uniprot/F6X2F7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC106781721 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GS79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:POLR2H ^@ http://purl.uniprot.org/uniprot/F7AS10 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/9796:ASIP ^@ http://purl.uniprot.org/uniprot/Q95MP2 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).|||Secreted|||The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. http://togogenome.org/gene/9796:LOC106781464 ^@ http://purl.uniprot.org/uniprot/A0A5F5PWY7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:SF3B3 ^@ http://purl.uniprot.org/uniprot/F7BGG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:SKI ^@ http://purl.uniprot.org/uniprot/Q9TUG2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SKI family.|||Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes (By similarity).|||May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling (By similarity).|||Nucleus|||Ubiquitinated by ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling. http://togogenome.org/gene/9796:PORCN ^@ http://purl.uniprot.org/uniprot/A0A3Q2LNB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100060302 ^@ http://purl.uniprot.org/uniprot/F6WXQ1 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:INPP5A ^@ http://purl.uniprot.org/uniprot/A0A3Q2L3B5 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/9796:RANBP6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RIA1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9796:LOC100049851 ^@ http://purl.uniprot.org/uniprot/F6QDH8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/9796:LOC100072080 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KR99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TNS4 ^@ http://purl.uniprot.org/uniprot/F6VZB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9796:MSH4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SAU3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/9796:PBRM1 ^@ http://purl.uniprot.org/uniprot/F6WW81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:ZSCAN9 ^@ http://purl.uniprot.org/uniprot/A0A9L0SAE2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:SKA3 ^@ http://purl.uniprot.org/uniprot/F7CNU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/9796:LPIN2 ^@ http://purl.uniprot.org/uniprot/F7CLR0 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9796:NR0B2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TP37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:ITM2B ^@ http://purl.uniprot.org/uniprot/A0A9L0S909 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9796:PDHX ^@ http://purl.uniprot.org/uniprot/A0A9L0SU38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9796:PDE6D ^@ http://purl.uniprot.org/uniprot/A0A9L0RTK2|||http://purl.uniprot.org/uniprot/A0A9L0S0U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9796:GPR1 ^@ http://purl.uniprot.org/uniprot/F7AHQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/F7CZA7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9796:ACVR2A ^@ http://purl.uniprot.org/uniprot/F7CD19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9796:C5H1orf74 ^@ http://purl.uniprot.org/uniprot/A0A9L0TAK8 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/9796:ACE ^@ http://purl.uniprot.org/uniprot/A0A9R1SBF5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M2 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/9796:HAPLN1 ^@ http://purl.uniprot.org/uniprot/Q28381 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAPLN family.|||Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.|||extracellular matrix http://togogenome.org/gene/9796:LOC100054762 ^@ http://purl.uniprot.org/uniprot/F6QK06 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:C18H2orf88 ^@ http://purl.uniprot.org/uniprot/A0A9L0RUM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:ARL8B ^@ http://purl.uniprot.org/uniprot/F6RIG2 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||spindle http://togogenome.org/gene/9796:LOC100068510 ^@ http://purl.uniprot.org/uniprot/F6SRI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:LOC100072638 ^@ http://purl.uniprot.org/uniprot/F7A4U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NMB ^@ http://purl.uniprot.org/uniprot/A0A9L0TSP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted|||neuron projection http://togogenome.org/gene/9796:FOXN3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H6L9 ^@ Function|||Subcellular Location Annotation ^@ Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|||Nucleus http://togogenome.org/gene/9796:LOC100054260 ^@ http://purl.uniprot.org/uniprot/F6ZTL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9796:IFNK ^@ http://purl.uniprot.org/uniprot/F6XJ71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:LOC100068578 ^@ http://purl.uniprot.org/uniprot/F6W7A4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CAPN3 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q268|||http://purl.uniprot.org/uniprot/A0A9L0RQF0|||http://purl.uniprot.org/uniprot/A0A9L0SGH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9796:ABCA9 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H8Q4|||http://purl.uniprot.org/uniprot/F6TR54 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CRP ^@ http://purl.uniprot.org/uniprot/F6PZG1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/9796:ELOVL4 ^@ http://purl.uniprot.org/uniprot/F6VSU8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.|||Endoplasmic reticulum membrane|||Membrane|||Oligomer.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9796:EFNB3 ^@ http://purl.uniprot.org/uniprot/B0LDT3 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:INSL6 ^@ http://purl.uniprot.org/uniprot/A0A9L0TE83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9796:PBX1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HR30|||http://purl.uniprot.org/uniprot/A0A9L0RWB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9796:PPP4C ^@ http://purl.uniprot.org/uniprot/F6X854 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9796:CCDC85A ^@ http://purl.uniprot.org/uniprot/A0A3Q2H423|||http://purl.uniprot.org/uniprot/A0A3Q2HFV8|||http://purl.uniprot.org/uniprot/A0A3Q2HPR2|||http://purl.uniprot.org/uniprot/A0A9L0T7V3|||http://purl.uniprot.org/uniprot/F6YUD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/9796:BDKRB1 ^@ http://purl.uniprot.org/uniprot/F7CTN3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/9796:SASS6 ^@ http://purl.uniprot.org/uniprot/A0A9L0SXT8 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/9796:IL12RB2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWE9|||http://purl.uniprot.org/uniprot/F6YRY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9796:SLC26A2 ^@ http://purl.uniprot.org/uniprot/Q65AC2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||N-glycosylated.|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (By similarity). Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity). http://togogenome.org/gene/9796:PTGDR2 ^@ http://purl.uniprot.org/uniprot/F6TM20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9796:SAMD8 ^@ http://purl.uniprot.org/uniprot/A0A9L0R1U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9796:PYGM ^@ http://purl.uniprot.org/uniprot/B9A9U9 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9796:SLC6A4 ^@ http://purl.uniprot.org/uniprot/F6QG30|||http://purl.uniprot.org/uniprot/Q14UY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Membrane|||Synapse|||focal adhesion|||neuron projection http://togogenome.org/gene/9796:RSPO1 ^@ http://purl.uniprot.org/uniprot/A8C9U0 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9796:LOC100070786 ^@ http://purl.uniprot.org/uniprot/F6QIL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:AVPR2 ^@ http://purl.uniprot.org/uniprot/F6UX08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.|||Membrane http://togogenome.org/gene/9796:TLR9 ^@ http://purl.uniprot.org/uniprot/Q2EEY0 ^@ Developmental Stage|||Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.|||Belongs to the Toll-like receptor family.|||By mitogen phytohaemagglutinin (PHA) in peripheral blood mononuclear cells (PBMCs) (PubMed:18462806). By lipopolysaccharide (LPS) in cells of the lung septa. This induction is abolished by gadolinium chloride treatment which depletes pulmonary intravascular macrophages (PIMs) (PubMed:19548205). By synthetic class C cytidine-phosphate-guanosine oligodeoxynucleotides (CpG-ODNs) in PBMCs (PubMed:25066759). Synthetic class B CpG-ODN does not induce a significant increase of expression in vitro in neutrophils of foals aged between 2 to 56 days nor in adult horses (PubMed:22197007, PubMed:19819162). Expression level in neutrophils is not significantly changed by virulent strain of R.equi bacterium (PubMed:19819162). Up-regulated by neuropathogenic equine herpesvirus-1 (EHV-1) infection in fully differentiated equine respiratory epithelial cells (ERECs) cultured at the air-fluid interface (AFI) (PubMed:24560592). Up-regulated in gingival tissue in individuals with equine periodontal disease. 16-fold increase in expression at diseased sites of the gums compared to healthy sites of the same animal (PubMed:27270960).|||Cell membrane|||Cytoplasm|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Endosome|||Expressed in airway epithelium, vascular endothelium and inflammatory cells in blood vessels of the lungs (at protein level). Highly expressed in pulmonary intravascular macrophages (PIMs) and to a lesser extent in alveolar macrophages, neutrophiles, type-II alveolar epithelial cells and bronchial epithelial cells of the lungs (at protein level) (PubMed:19548205). High constitutive intracellular expression in leukocytes including polymorphonuclear leukocytes (PMNs), CD4 and CD8 T cells (at protein level) (PubMed:18462806). Expressed throughout the respiratory tract including larynx, upper, middle and lower trachea, and bronchus in isolated equine respiratory epithelial cells (ERECs) and in fully differentiated ERECs cultured at the air-fluid interface (AFI) (at protein level) (PubMed:21292331). Constitutively expressed in peripheral blood mononuclear cells (PBMCs), lymph nodes and spleen. The level of expression in PBMCs is about 2- to 3-fold higher than that in lymph nodes and spleen. Very low expression in liver, heart, lung, kidney, small intestine, colon and stomach (PubMed:18462806). Low expression in the airway tissue epithelium of the larynx, upper trachea, middle tranchea, lower trachea, bronchus and spleen, and more abundant expression in mesenteric lymph node. Not expressed in fully differentiated bronchus epithelial cells cultured at the AFI for four weeks (PubMed:21292331). Expressed in gingival tissue (PubMed:27270960).|||Expression increases with age in neutrophils of an individual foal aged between 2 to 56 days (PubMed:22197007). Expression in neutrophils of a foal at age 1 day, another different foal at age 56 days, and of an adult horse is constitutive at a very low level (PubMed:19819162).|||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).|||Lysosome|||Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (PubMed:25686612). Interacts with MYD88 via their respective TIR domains (By similarity). Interacts with BTK (By similarity). Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with SMPDL3B (By similarity).|||Nucleus|||phagosome http://togogenome.org/gene/9796:ABCA6 ^@ http://purl.uniprot.org/uniprot/F7CQG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:SLC25A20 ^@ http://purl.uniprot.org/uniprot/A0A9L0R5Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:CA5A ^@ http://purl.uniprot.org/uniprot/F7C2P4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9796:RPLP0 ^@ http://purl.uniprot.org/uniprot/A0A9R1SD87 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/9796:LOC100050904 ^@ http://purl.uniprot.org/uniprot/F7D7T6 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9796:ATP2A1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNX8|||http://purl.uniprot.org/uniprot/A0A5F5PZQ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9796:ADORA2A ^@ http://purl.uniprot.org/uniprot/Q6TLI7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (By similarity). May interact with DRD4 (By similarity). Interacts with NECAB2 (By similarity). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (By similarity).|||Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).|||The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.|||Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity). http://togogenome.org/gene/9796:LOC100058884 ^@ http://purl.uniprot.org/uniprot/A0A5F5PIT3|||http://purl.uniprot.org/uniprot/F7AKZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9796:SLC6A14 ^@ http://purl.uniprot.org/uniprot/F6WG98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9796:LOC102150222 ^@ http://purl.uniprot.org/uniprot/F6ZNY8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9796:CYP3A96 ^@ http://purl.uniprot.org/uniprot/C9WMG3|||http://purl.uniprot.org/uniprot/D7GB59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:KRT36 ^@ http://purl.uniprot.org/uniprot/F6SKY2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:RAP2C ^@ http://purl.uniprot.org/uniprot/K9K4A9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9796:LOC102148675 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I6Q5 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9796:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/A0A9L0RYK6|||http://purl.uniprot.org/uniprot/F6R176 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/9796:PIK3CA ^@ http://purl.uniprot.org/uniprot/F6VFI8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9796:CHRNB3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T627 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:S100PBP ^@ http://purl.uniprot.org/uniprot/A0A3Q2KSW7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PLA2G4B ^@ http://purl.uniprot.org/uniprot/A0A5F5PU79 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/9796:GTPBP10 ^@ http://purl.uniprot.org/uniprot/A0A9L0TC85|||http://purl.uniprot.org/uniprot/F6QNV9 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9796:SSR2 ^@ http://purl.uniprot.org/uniprot/F7BIU0|||http://purl.uniprot.org/uniprot/K9K263 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9796:SLC8A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RNX4|||http://purl.uniprot.org/uniprot/A0A9L0RX68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PROX1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TTL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:IFRD1 ^@ http://purl.uniprot.org/uniprot/F6S173 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/9796:LYZL1 ^@ http://purl.uniprot.org/uniprot/F7DXW1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9796:GPR18 ^@ http://purl.uniprot.org/uniprot/F6VVV7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:LOC100067037 ^@ http://purl.uniprot.org/uniprot/A0A9L0TFN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CAPZA2 ^@ http://purl.uniprot.org/uniprot/Q2QLA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity). http://togogenome.org/gene/9796:ASNA1 ^@ http://purl.uniprot.org/uniprot/F7BUE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/9796:CSTF2T ^@ http://purl.uniprot.org/uniprot/F6S3U2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:CCNA1 ^@ http://purl.uniprot.org/uniprot/F7DJ56 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9796:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HB49|||http://purl.uniprot.org/uniprot/A0A3Q2L1L3|||http://purl.uniprot.org/uniprot/F7C4U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9796:AMZ2 ^@ http://purl.uniprot.org/uniprot/F7BML9 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/9796:MED20 ^@ http://purl.uniprot.org/uniprot/A0A9L0S1L6|||http://purl.uniprot.org/uniprot/A0A9L0T048 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9796:CYP27A1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZA7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9796:LOC100062019 ^@ http://purl.uniprot.org/uniprot/F6YSJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TMEM150A ^@ http://purl.uniprot.org/uniprot/A0A3Q2L0E3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ORC5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IA91 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100053601 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HX90 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9796:FAM135A ^@ http://purl.uniprot.org/uniprot/F6QGN5|||http://purl.uniprot.org/uniprot/F6RFE4 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9796:GH1 ^@ http://purl.uniprot.org/uniprot/P01245 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.|||Secreted http://togogenome.org/gene/9796:CADM1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PGJ5|||http://purl.uniprot.org/uniprot/A0A5F5PQK7|||http://purl.uniprot.org/uniprot/A0A5F5Q191|||http://purl.uniprot.org/uniprot/A0A9L0SML0 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9796:PLA2G2F ^@ http://purl.uniprot.org/uniprot/F6U5U8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9796:CXCL13 ^@ http://purl.uniprot.org/uniprot/F6ZX45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9796:LY49D ^@ http://purl.uniprot.org/uniprot/Q75XR6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CDKN3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HM40|||http://purl.uniprot.org/uniprot/F6VTZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||perinuclear region http://togogenome.org/gene/9796:SIKE1 ^@ http://purl.uniprot.org/uniprot/F6VMX0 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9796:LOC100053897 ^@ http://purl.uniprot.org/uniprot/A0A9L0SLK5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:ADGRB3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SWT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100062625 ^@ http://purl.uniprot.org/uniprot/A0A9L0RGG6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:HTR5A ^@ http://purl.uniprot.org/uniprot/F7A8C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:OLFM1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GU19 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9796:MMGT1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0T6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/9796:HNRNPH2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RA18 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9796:CXCL2 ^@ http://purl.uniprot.org/uniprot/B7UBX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9796:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/F7CMI0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9796:CXHXorf56 ^@ http://purl.uniprot.org/uniprot/A0A9L0RUD5 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9796:CEP19 ^@ http://purl.uniprot.org/uniprot/F7DP40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/9796:LOC100053249 ^@ http://purl.uniprot.org/uniprot/A0A9L0S861 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GST superfamily. Pi family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9796:CENPQ ^@ http://purl.uniprot.org/uniprot/A0A9L0SW06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-Q/OKP1 family.|||Nucleus http://togogenome.org/gene/9796:COPS5 ^@ http://purl.uniprot.org/uniprot/A0A9R1SEI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9796:RPL23A ^@ http://purl.uniprot.org/uniprot/A0A9R1SRV1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9796:LOC100068867 ^@ http://purl.uniprot.org/uniprot/F7C4C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:IL2RA ^@ http://purl.uniprot.org/uniprot/A8VUE0 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/9796:CNOT10 ^@ http://purl.uniprot.org/uniprot/F6YT67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:RNPS1 ^@ http://purl.uniprot.org/uniprot/F6U567 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus speckle http://togogenome.org/gene/9796:CXCR6 ^@ http://purl.uniprot.org/uniprot/F6XQ88 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:RSAD2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HZ24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9796:TRIM32 ^@ http://purl.uniprot.org/uniprot/F6YCR4 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9796:SLC35A2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TTK6|||http://purl.uniprot.org/uniprot/F7C7T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:TGM1 ^@ http://purl.uniprot.org/uniprot/F6PW39 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9796:CA4 ^@ http://purl.uniprot.org/uniprot/F6UPK3 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9796:AMH ^@ http://purl.uniprot.org/uniprot/F2YMM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation and plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.|||Secreted http://togogenome.org/gene/9796:MARK2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RS62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9796:DARS ^@ http://purl.uniprot.org/uniprot/F6WZB7 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9796:MAB21L1 ^@ http://purl.uniprot.org/uniprot/F6Q0X3 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9796:LTA ^@ http://purl.uniprot.org/uniprot/A0A0U5J6U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.|||Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.|||Membrane|||Secreted http://togogenome.org/gene/9796:HNF4G ^@ http://purl.uniprot.org/uniprot/A0A9L0RW57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9796:ZKSCAN5 ^@ http://purl.uniprot.org/uniprot/A0A9L0TK19|||http://purl.uniprot.org/uniprot/F6SQV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:CSF1R ^@ http://purl.uniprot.org/uniprot/Q4W447 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:GLRA3 ^@ http://purl.uniprot.org/uniprot/A0A5F5PZC8|||http://purl.uniprot.org/uniprot/F6YBB6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9796:LMOD3 ^@ http://purl.uniprot.org/uniprot/F6UIX7 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9796:LOC100071714 ^@ http://purl.uniprot.org/uniprot/F6YD73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9796:HAO1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RS57 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/9796:TAAR4 ^@ http://purl.uniprot.org/uniprot/F7BPI5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:GHSR ^@ http://purl.uniprot.org/uniprot/F6QF00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:SH3BGR ^@ http://purl.uniprot.org/uniprot/A0A9L0R6Z6 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9796:ERG ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:RPS4X ^@ http://purl.uniprot.org/uniprot/F7DFM3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/9796:SCGB1A1 ^@ http://purl.uniprot.org/uniprot/I1VZ94|||http://purl.uniprot.org/uniprot/I1VZ96|||http://purl.uniprot.org/uniprot/Q8MKG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Antiparallel homodimer; disulfide-linked (By similarity). Interaction with LMBR1L is controversial (By similarity).|||Belongs to the secretoglobin family.|||Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.|||Club cells (nonciliated cells of the surface epithelium of the pulmonary airways). Expressed in lung, uterus, and prostate.|||Secreted http://togogenome.org/gene/9796:TMPRSS11A ^@ http://purl.uniprot.org/uniprot/A0A9L0QXE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9796:CKMT2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PKR4 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9796:SLC5A6 ^@ http://purl.uniprot.org/uniprot/F6WAA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:HMGCL ^@ http://purl.uniprot.org/uniprot/A0A3Q2HV64|||http://purl.uniprot.org/uniprot/F6Q4C8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/9796:LOC100067439 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KJ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9796:COG4 ^@ http://purl.uniprot.org/uniprot/F7D287 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9796:RAB27B ^@ http://purl.uniprot.org/uniprot/A0A9L0RNJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9796:SLC22A18 ^@ http://purl.uniprot.org/uniprot/A0A5F5PW80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:USP21 ^@ http://purl.uniprot.org/uniprot/A0A9L0R379 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9796:GABRQ ^@ http://purl.uniprot.org/uniprot/A0A3Q2HTG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:C20H6orf89 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GW88|||http://purl.uniprot.org/uniprot/A0A9L0TQQ1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:KIF16B ^@ http://purl.uniprot.org/uniprot/F6UWF5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9796:SLC46A1 ^@ http://purl.uniprot.org/uniprot/F6UGY6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:SMG7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L5D0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9796:RGS5 ^@ http://purl.uniprot.org/uniprot/F7C833 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/9796:DCTN2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HP50|||http://purl.uniprot.org/uniprot/F7BSK7 ^@ Similarity ^@ Belongs to the dynactin subunit 2 family. http://togogenome.org/gene/9796:PHF5A ^@ http://purl.uniprot.org/uniprot/K9K4M9 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/9796:CXHXorf36 ^@ http://purl.uniprot.org/uniprot/F6XDM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/9796:ZSCAN23 ^@ http://purl.uniprot.org/uniprot/A0A9L0S5H4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:RPL5 ^@ http://purl.uniprot.org/uniprot/A0A5K1VP18|||http://purl.uniprot.org/uniprot/Q8MIN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9796:KRT33A ^@ http://purl.uniprot.org/uniprot/F6VDK7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:SST ^@ http://purl.uniprot.org/uniprot/F6TIY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9796:FASN ^@ http://purl.uniprot.org/uniprot/F7DDN1 ^@ Function ^@ Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. http://togogenome.org/gene/9796:IQCD ^@ http://purl.uniprot.org/uniprot/A0A9L0TCF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/9796:PSMD5 ^@ http://purl.uniprot.org/uniprot/F7BBH3 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/9796:MYOG ^@ http://purl.uniprot.org/uniprot/A0A090BWQ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:MIP-2BETA ^@ http://purl.uniprot.org/uniprot/B7UBT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9796:CRISP2 ^@ http://purl.uniprot.org/uniprot/Q8HX97 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC106782093 ^@ http://purl.uniprot.org/uniprot/F7DFF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SMUG1 ^@ http://purl.uniprot.org/uniprot/F7DGX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/9796:TM2D2 ^@ http://purl.uniprot.org/uniprot/F6SCH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:FAM161A ^@ http://purl.uniprot.org/uniprot/A0A9L0RG18 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/9796:TMEM211 ^@ http://purl.uniprot.org/uniprot/F7AR42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:IL1B ^@ http://purl.uniprot.org/uniprot/A0A5F5Q2Z8|||http://purl.uniprot.org/uniprot/Q28386 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling. Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form. Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC. Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC.|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/9796:NEDD8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SJT8 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/9796:LTBR ^@ http://purl.uniprot.org/uniprot/A0A9L0SWA1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:UBE2N ^@ http://purl.uniprot.org/uniprot/F6ZNY8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9796:RGS1 ^@ http://purl.uniprot.org/uniprot/Q6RG78 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with GNAI1 and GNAQ.|||Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity).|||cytosol http://togogenome.org/gene/9796:LOC100052445 ^@ http://purl.uniprot.org/uniprot/A0A9L0SF33 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:B2M ^@ http://purl.uniprot.org/uniprot/K9K497|||http://purl.uniprot.org/uniprot/P30441 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-2-microglobulin family.|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).|||Secreted http://togogenome.org/gene/9796:CSN1S2 ^@ http://purl.uniprot.org/uniprot/A0A0C5DH76|||http://purl.uniprot.org/uniprot/D2KAS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-casein family.|||Important role in the capacity of milk to transport calcium phosphate.|||Secreted http://togogenome.org/gene/9796:SIRT4 ^@ http://purl.uniprot.org/uniprot/A0A9L0S2L1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.|||Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.|||Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.|||Mitochondrion matrix http://togogenome.org/gene/9796:UFL1 ^@ http://purl.uniprot.org/uniprot/K9KFF8|||http://purl.uniprot.org/uniprot/L7MSB8 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/9796:HPX ^@ http://purl.uniprot.org/uniprot/F6X1I8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/9796:LY49E ^@ http://purl.uniprot.org/uniprot/Q75XR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CPN1 ^@ http://purl.uniprot.org/uniprot/F6WZA8 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9796:CPS1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNI4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:SLC24A5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HAS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9796:DCT ^@ http://purl.uniprot.org/uniprot/A0A9L0SRE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9796:LOC100050004 ^@ http://purl.uniprot.org/uniprot/A0A5F5PWV7 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/9796:RNASE6 ^@ http://purl.uniprot.org/uniprot/F7APT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9796:ECHDC1 ^@ http://purl.uniprot.org/uniprot/K9K4E3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9796:ZIC4 ^@ http://purl.uniprot.org/uniprot/F7CLD2 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9796:LOC100054010 ^@ http://purl.uniprot.org/uniprot/F6W778 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:EEF1A1 ^@ http://purl.uniprot.org/uniprot/A2Q0Z0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cell membrane|||Cytoplasm|||Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1 and TXK. Interacts with KARS1. May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). May interact with ERGIC2. Interacts with IFIT1 (via TPR repeats 4-7) (By similarity). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner (By similarity). Interacts with PPP1R16B (By similarity). Interacts with SPHK1 and SPHK2; both interactions increase SPHK1 and SPHK2 kinase activity (By similarity).|||ISGylated.|||Nucleus|||Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2. Phosphorylation by TGFBR1 inhibits translation elongation.|||Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.|||Trimethylated at Lys-79 by EEF1AKMT1. Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. Trimethylated at Lys-318 by EEF1AKMT2. Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs. Trimethylated at Gly-2 by METTL13. Mono- and dimethylated at Lys-55 by METTL13; dimethylated form is predominant.|||Ubiquitinated at Lys-385 by RNF14 in response to ribosome collisions (ribosome stalling), leading to its degradation by the proteasome and rescue of stalled ribosomes.|||nucleolus http://togogenome.org/gene/9796:SDE2 ^@ http://purl.uniprot.org/uniprot/F6V3M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:ASPA ^@ http://purl.uniprot.org/uniprot/A0A5F5PM60 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9796:COMT ^@ http://purl.uniprot.org/uniprot/Q5H879 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.|||Cell membrane|||Cytoplasm http://togogenome.org/gene/9796:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RVP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:VWC2 ^@ http://purl.uniprot.org/uniprot/F7CW74 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9796:RPL18 ^@ http://purl.uniprot.org/uniprot/Q0QEV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9796:NPY2R ^@ http://purl.uniprot.org/uniprot/F6X314 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:RBM42 ^@ http://purl.uniprot.org/uniprot/A0A5F5PY96 ^@ Similarity ^@ Belongs to the RRM RBM42 family. http://togogenome.org/gene/9796:GC ^@ http://purl.uniprot.org/uniprot/F6T0P6 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/9796:ANKRD34C ^@ http://purl.uniprot.org/uniprot/F6R3L8 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9796:STS ^@ http://purl.uniprot.org/uniprot/A0A9L0RB80 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9796:ALDOB ^@ http://purl.uniprot.org/uniprot/F6ULM3 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9796:LYZ ^@ http://purl.uniprot.org/uniprot/F7CU94 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9796:LOC100070828 ^@ http://purl.uniprot.org/uniprot/F7A663 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DRA ^@ http://purl.uniprot.org/uniprot/K9MCF1 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9796:CD40 ^@ http://purl.uniprot.org/uniprot/Q3ZTK5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Membrane|||Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).|||Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). http://togogenome.org/gene/9796:TNFSF13B ^@ http://purl.uniprot.org/uniprot/F2VR36 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9796:AQP4 ^@ http://purl.uniprot.org/uniprot/F6SPF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:NIPAL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TGJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9796:LIN28A ^@ http://purl.uniprot.org/uniprot/F7DH54 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9796:FUT8 ^@ http://purl.uniprot.org/uniprot/F7DPM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9796:LOC100056780 ^@ http://purl.uniprot.org/uniprot/F6UFW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:S100A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R819 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Mitochondrion http://togogenome.org/gene/9796:ATP1B4 ^@ http://purl.uniprot.org/uniprot/F7AK66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9796:TGFB1 ^@ http://purl.uniprot.org/uniprot/O19011 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction.|||Homodimer; disulfide-linked. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling and the HTRA protease activity is required for this inhibition. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with CD109, DPT and ASPN. Interacts with EFEMP2. Interacts with TSKU; the interaction contributes to regulation of the hair cycle.|||Homodimer; disulfide-linked. Interacts with transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains TGF-beta-1 in a latent state; each latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Interacts with LTBP1; leading to regulation of TGF-beta-1 activation. Interacts with LRRC32/GARP; leading to regulation of TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Interacts with LRRC33/NRROS; leading to regulation of TGF-beta-1 activation in macrophages and microglia. Interacts (via cell attachment site) with integrins ITGAV and ITGB6 (ITGAV:ITGB6), leading to release of the active TGF-beta-1. Latency-associated peptide: Interacts with NREP; the interaction results in a decrease in TGFB1 autoinduction. Interacts with HSP90AB1; inhibits latent TGFB1 activation.|||Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Positively regulates odontoblastic differentiation in dental papilla cells, via promotion of IPO7-mediated translocation of phosphorylated SMAD2 to the nucleus and subsequent transcription of target genes (By similarity). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).|||N-glycosylated. Deglycosylation leads to activation of Transforming growth factor beta-1 (TGF-beta-1); mechanisms triggering deglycosylation-driven activation of TGF-beta-1 are however unclear.|||Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.|||Secreted|||The 'straitjacket' and 'arm' domains encircle the Transforming growth factor beta-1 (TGF-beta-1) monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104.|||The cell attachment site motif mediates binding to integrins (ITGAV:ITGB6 or ITGAV:ITGB8). The motif locates to a long loop in the arm domain called the bowtie tail. Integrin-binding stabilizes an alternative conformation of the bowtie tail. Activation by integrin requires force application by the actin cytoskeleton, which is resisted by the 'milieu molecules' (such as LTBP1, LRRC32/GARP and/or LRRC33/NRROS), resulting in distortion of the prodomain and release of the active TGF-beta-1.|||Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.|||Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.|||extracellular matrix http://togogenome.org/gene/9796:TMEM126A ^@ http://purl.uniprot.org/uniprot/A0A9L0R9D5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:HSPA8 ^@ http://purl.uniprot.org/uniprot/A2Q0Z1 ^@ Domain|||Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated.|||Belongs to the heat shock protein 70 family.|||Cell membrane|||Constitutively synthesized.|||Cytoplasm|||ISGylated.|||Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Interacts with PACRG (By similarity). Interacts with HSPH1/HSP105 (By similarity). Interacts with IRAK1BP1 and BAG1 (By similarity). Interacts with DNAJC7 (By similarity). Interacts with DNAJB12 (via J domain) (By similarity). Interacts with DNAJB14 (via J domain) (By similarity). Interacts (via C-terminus) with the E3 ligase STUB1 forming a 210 kDa complex of one STUB1 and two HSPA8 molecules (By similarity). Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation (By similarity). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (By similarity). Interacts with TRIM5 (By similarity). Part of a complex composed at least of ASH2L, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Interacts with METTL21A (By similarity). Following LPS binding, may form a complex with CXCR4, GDF5 and HSP90AA1 (By similarity). Interacts with PRKN (By similarity). Interacts with FOXP3 (By similarity). Interacts with DNAJC9 (via J domain) (By similarity). Interacts with MLLT11 (By similarity). Interacts with RNF207 (By similarity). Interacts with DNAJC21 (By similarity). Interacts with DNAJB2 (By similarity). Interacts with TTC1 (via TPR repeats) (By similarity). Interacts with SGTA (via TPR repeats) (By similarity). Interacts with HSF1 (via transactivation domain) (By similarity). Interacts with HOPX, STUB1, HSP40, HSP901, BAG2 and BAG3 (By similarity). Interacts with HSPC138 (By similarity). Interacts with ZMYND10 (By similarity). Interacts with VGF-derived peptide TLQP-21 (By similarity). Interacts with BCL2L1, GIMAP5 and MCL1; the interaction with BCL2L1 or MCL1 is impaired in the absence of GIMAP5 (By similarity). Interacts with NLPR12 (By similarity). Interacts with TTC4 (By similarity). Interacts with TOMM70; the interaction is required for preprotein mitochondrial import (By similarity). May interact with DNJC9; the interaction seems to be histone-dependent (By similarity). Interacts with BAG5 and JPH2; the interaction with JPH2 is increased in the presence of BAG5 (By similarity).|||Lysosome membrane|||Melanosome|||Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2. KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21.|||The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.|||Trimethylation at Lys-561 reduces fibrillar SNCA binding.|||nucleolus http://togogenome.org/gene/9796:IGF2 ^@ http://purl.uniprot.org/uniprot/P51459|||http://purl.uniprot.org/uniprot/W8VNM5 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Interacts with MYORG; this interaction is required for IGF2 secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.|||Secreted|||The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced.|||The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).|||The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate. http://togogenome.org/gene/9796:CCR4 ^@ http://purl.uniprot.org/uniprot/F6RJT2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:CRBN ^@ http://purl.uniprot.org/uniprot/F6VJQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/9796:RARS ^@ http://purl.uniprot.org/uniprot/F6YPN7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9796:KITLG ^@ http://purl.uniprot.org/uniprot/A0A5S7PHS1|||http://purl.uniprot.org/uniprot/Q95MD2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A soluble form is produced by proteolytic processing of the extracellular domain.|||Belongs to the SCF family.|||Cell membrane|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity).|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9796:CFTR ^@ http://purl.uniprot.org/uniprot/Q2QLA3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Binds and hydrolyzes ATP via the two cytoplasmic ABC transporter nucleotide-binding domains. The two ATP-binding domains interact with each other, forming a head-to-tail dimer. Normal ATPase activity requires interaction between the two domains. The first ABC transporter nucleotide-binding domain has no ATPase activity by itself.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation (By similarity).|||N-glycosylated.|||Nucleus|||Phosphorylated; cAMP treatment promotes phosphorylation and activates the channel. Dephosphorylation decreases the ATPase activity (in vitro). Phosphorylation at PKA sites activates the channel. Phosphorylation at PKC sites enhances the response to phosphorylation by PKA. Phosphorylated by AMPK; this inhibits channel activity.|||Recycling endosome membrane|||The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, NHERF1/EBP50 complex.|||The disordered R region mediates channel activation when it is phosphorylated, but not in the absence of phosphorylation.|||Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes enhances its endocytic recycling to the cell membrane. Ubiquitinated by RNF185 during ER stress. Ubiquitinated by MARCHF2 (By similarity). http://togogenome.org/gene/9796:EIF4E1B ^@ http://purl.uniprot.org/uniprot/A0A9L0S2V2 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9796:TMEM167A ^@ http://purl.uniprot.org/uniprot/L7MSG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/9796:CYB561A3 ^@ http://purl.uniprot.org/uniprot/A0A5F5PJV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:GABRE ^@ http://purl.uniprot.org/uniprot/F6XL48 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:SLA ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZ94 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:IRF7 ^@ http://purl.uniprot.org/uniprot/F6YQ51 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:FREM1 ^@ http://purl.uniprot.org/uniprot/F6T9P2 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/9796:PARP11 ^@ http://purl.uniprot.org/uniprot/F7B5H0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9796:STPG1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GY20 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9796:GNPDA2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HTN4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9796:ZRANB1 ^@ http://purl.uniprot.org/uniprot/F6SWW9 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/9796:FAM46A ^@ http://purl.uniprot.org/uniprot/A0A9L0TFZ4 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9796:DRD3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4H7|||http://purl.uniprot.org/uniprot/F6X207 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.|||Membrane http://togogenome.org/gene/9796:MID1 ^@ http://purl.uniprot.org/uniprot/F7CLC3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9796:SLC4A8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SSL5 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9796:PFKM ^@ http://purl.uniprot.org/uniprot/A0A3Q2GST7|||http://purl.uniprot.org/uniprot/A0A9L0RR79|||http://purl.uniprot.org/uniprot/Q867C9 ^@ Activity Regulation|||Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||GlcNAcylation decreases enzyme activity.|||Homo- and heterotetramers (By similarity). Phosphofructokinase (PFK) enzyme functions as a tetramer composed of different combinations of 3 types of subunits, called PFKM (M), PFKL (L) and PFKP (P). The composition of the PFK tetramer differs according to the tissue type it is present in. The kinetic and regulatory properties of the tetrameric enzyme are dependent on the subunit composition, hence can vary across tissues (Probable). Interacts (via C-terminus) with HK1 (via N-terminal spermatogenic cell-specific region) (By similarity).|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LRRC8A ^@ http://purl.uniprot.org/uniprot/F7BJ71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:GJB6 ^@ http://purl.uniprot.org/uniprot/A0A654IDL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:CD200R1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GU91 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/9796:LOC100072672 ^@ http://purl.uniprot.org/uniprot/A0A9L0TU96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9796:DDIT4 ^@ http://purl.uniprot.org/uniprot/F6WW89 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9796:LOC100061889 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KXJ9 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9796:CCDC124 ^@ http://purl.uniprot.org/uniprot/A0A9L0RI33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC124 family.|||Midbody http://togogenome.org/gene/9796:CDH11 ^@ http://purl.uniprot.org/uniprot/B8K205 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:MNAT1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SC84 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/9796:FSCN3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SFJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9796:LOC100053210 ^@ http://purl.uniprot.org/uniprot/F7A317 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:RSPO2 ^@ http://purl.uniprot.org/uniprot/A8C9U1 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9796:EPO ^@ http://purl.uniprot.org/uniprot/Q867B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.|||Secreted http://togogenome.org/gene/9796:LOC100058575 ^@ http://purl.uniprot.org/uniprot/F6RHU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9796:ITK ^@ http://purl.uniprot.org/uniprot/A0A9L0RA54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:TBX19 ^@ http://purl.uniprot.org/uniprot/A0A5F5PTJ6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9796:CAVIN4 ^@ http://purl.uniprot.org/uniprot/F7A8K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9796:CPQ ^@ http://purl.uniprot.org/uniprot/A0A3Q2HC40 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome http://togogenome.org/gene/9796:LOC100064468 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q1L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:NOL10 ^@ http://purl.uniprot.org/uniprot/F6U0I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9796:MST1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S9Z6 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:TBX6 ^@ http://purl.uniprot.org/uniprot/F6ZBV5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9796:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/F7BRW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:DDX47 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KQR1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/9796:NECTIN4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4D7 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9796:LOC100069048 ^@ http://purl.uniprot.org/uniprot/F6U7B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TMEM184B ^@ http://purl.uniprot.org/uniprot/A0A9L0TPQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100064960 ^@ http://purl.uniprot.org/uniprot/F6ZF60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:B3GALT5 ^@ http://purl.uniprot.org/uniprot/F6QMK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:TRIM67 ^@ http://purl.uniprot.org/uniprot/F7CR77 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9796:SLC31A2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IB53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9796:MTG2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HYX8|||http://purl.uniprot.org/uniprot/A0A3Q2IL01 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9796:IFNE ^@ http://purl.uniprot.org/uniprot/A0A7R8C517 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:SARDH ^@ http://purl.uniprot.org/uniprot/A0A3Q2I3R6 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9796:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A9L0QZA9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9796:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/F6Z2J4 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9796:GALR1 ^@ http://purl.uniprot.org/uniprot/F7DSS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9796:OCM2 ^@ http://purl.uniprot.org/uniprot/A0A9L0T6T7 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9796:SULT6B1 ^@ http://purl.uniprot.org/uniprot/F6XSH3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:PIP ^@ http://purl.uniprot.org/uniprot/F6V6R7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PIP family.|||Monomer. Interacts with AZGP1.|||Secreted http://togogenome.org/gene/9796:LOC100067320 ^@ http://purl.uniprot.org/uniprot/F6VDB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SERINC3 ^@ http://purl.uniprot.org/uniprot/A0A9L0S7E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9796:LOC100071373 ^@ http://purl.uniprot.org/uniprot/F6TEU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/9796:SGMS1 ^@ http://purl.uniprot.org/uniprot/F7CZI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9796:RIPK2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HFQ8|||http://purl.uniprot.org/uniprot/F6T4A5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.|||Cytoplasm|||Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.|||Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments. http://togogenome.org/gene/9796:HBA ^@ http://purl.uniprot.org/uniprot/P01958 ^@ Function|||Polymorphism|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.|||Heterotetramer of two alpha chains and two beta chains.|||Horse has two non-allelic alpha chains, slow and fast. The slow chain sequence is shown.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/9796:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A7U3JWE0|||http://purl.uniprot.org/uniprot/F6XEK8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:TMA16 ^@ http://purl.uniprot.org/uniprot/A0A9L0R347 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/9796:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/A0A9L0S5K6|||http://purl.uniprot.org/uniprot/F6WEU3|||http://purl.uniprot.org/uniprot/K9KEX5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/9796:LOC100072086 ^@ http://purl.uniprot.org/uniprot/F6U7E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PPM1G ^@ http://purl.uniprot.org/uniprot/F6Z8G6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9796:LOC100062731 ^@ http://purl.uniprot.org/uniprot/F6U178 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CCNT1 ^@ http://purl.uniprot.org/uniprot/Q9XT26 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ADP-ribosylation on serine residues by PARP1 in response to DNA damage disrupts the phase separation activity of CCNT1, thereby preventing activation of CDK9.|||Belongs to the cyclin family. Cyclin C subfamily.|||Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb (By similarity). P-TEFb forms a complex with AFF4/AF5Q31 (By similarity). Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin (By similarity). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (By similarity). Interacts (via central region) with ZMYND8 (via N-terminus); the interaction is direct and the association appears to occur between homodimeric ZMYND8 and the activated form of the P-TEFb complex (By similarity). Interacts with BRD4, targets chromatin binding (By similarity). Interacts with JMJD6 (By similarity). Interacts with MDFIC (By similarity). Interacts with HSF1. Interacts with HTATSF1 (By similarity). Interacts with TBX21 (By similarity).|||Nucleus|||Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II.|||The histidine-rich domain (HRD) region is intrinsically disordered and promotes the formation of phase-separated liquid droplets that enhance binding of the P-TEFb complex to the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). http://togogenome.org/gene/9796:CLEC12A ^@ http://purl.uniprot.org/uniprot/A0A3Q2GYH6|||http://purl.uniprot.org/uniprot/A0A9L0RG78|||http://purl.uniprot.org/uniprot/A0A9L0TM65 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:GAL3ST3 ^@ http://purl.uniprot.org/uniprot/F6WHJ6 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/9796:GSTA1 ^@ http://purl.uniprot.org/uniprot/M9ZUR8 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9796:IL10 ^@ http://purl.uniprot.org/uniprot/B1AB84|||http://purl.uniprot.org/uniprot/Q28374 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-10 family.|||Homodimer. Interacts with IL10RA and IL10RB.|||Immune regulatory cytokine.|||Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).|||Secreted http://togogenome.org/gene/9796:LOC100068520 ^@ http://purl.uniprot.org/uniprot/F6TUQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PKMYT1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SIM4|||http://purl.uniprot.org/uniprot/A0A9L0T147 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:ABCA12 ^@ http://purl.uniprot.org/uniprot/F6ZHJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ZFHX3 ^@ http://purl.uniprot.org/uniprot/F6UNK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:CUL2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L9D5 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9796:LOC100068349 ^@ http://purl.uniprot.org/uniprot/A0A9L0TFE8|||http://purl.uniprot.org/uniprot/F6U4H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9796:ING2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RMW1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9796:KCNH2 ^@ http://purl.uniprot.org/uniprot/E0ADY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.|||Membrane http://togogenome.org/gene/9796:EXO1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TFM3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/9796:GPRC6A ^@ http://purl.uniprot.org/uniprot/F7AD15 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:TMPRSS15 ^@ http://purl.uniprot.org/uniprot/F7AVP5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DMBT1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:LOC100062119 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HJW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SLCO2B1 ^@ http://purl.uniprot.org/uniprot/Q30BK7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:LOC100050355 ^@ http://purl.uniprot.org/uniprot/A0A9R1SJZ0 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9796:PLP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HZI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9796:MEOX1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H6W3|||http://purl.uniprot.org/uniprot/F7AC26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:UQCRC2 ^@ http://purl.uniprot.org/uniprot/K9K4B9 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9796:TMC3 ^@ http://purl.uniprot.org/uniprot/F6TEP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/9796:HPDL ^@ http://purl.uniprot.org/uniprot/F7CX45 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9796:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PF28 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9796:INIP ^@ http://purl.uniprot.org/uniprot/F6WAD3|||http://purl.uniprot.org/uniprot/L7MS10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/9796:C5AR1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SBX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9796:TRAPPC3L ^@ http://purl.uniprot.org/uniprot/A0A9L0SYC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9796:PSD3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4F2 ^@ Subcellular Location Annotation ^@ Membrane|||ruffle membrane http://togogenome.org/gene/9796:LOC100072077 ^@ http://purl.uniprot.org/uniprot/F6VJW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:HR ^@ http://purl.uniprot.org/uniprot/F7BI66 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9796:VPS36 ^@ http://purl.uniprot.org/uniprot/K9K218 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/9796:LMF2 ^@ http://purl.uniprot.org/uniprot/A0A9L0R6G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lipase maturation factor family.|||Endoplasmic reticulum membrane|||Involved in the maturation of specific proteins in the endoplasmic reticulum.|||Membrane http://togogenome.org/gene/9796:PARP14 ^@ http://purl.uniprot.org/uniprot/F6S1K6 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9796:MNS1 ^@ http://purl.uniprot.org/uniprot/F6WA31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MNS1 family.|||Nucleus|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/9796:TNFSF12 ^@ http://purl.uniprot.org/uniprot/A0A0U5CJN1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9796:PML ^@ http://purl.uniprot.org/uniprot/A0A9L0RFN6|||http://purl.uniprot.org/uniprot/F7BQ20 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:CRISP3 ^@ http://purl.uniprot.org/uniprot/O19010 ^@ Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the CRISP family.|||Expressed in the salivary gland, in the ampulla and the seminal vesicle.|||Interacts with A1BG.|||Secreted http://togogenome.org/gene/9796:RND3 ^@ http://purl.uniprot.org/uniprot/F6S6C2 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/9796:GINS3 ^@ http://purl.uniprot.org/uniprot/F6YPP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/9796:MTERF2 ^@ http://purl.uniprot.org/uniprot/F7CST1 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/9796:TARDBP ^@ http://purl.uniprot.org/uniprot/F6WAU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:RPL13 ^@ http://purl.uniprot.org/uniprot/F6ZX61 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/9796:RDH13 ^@ http://purl.uniprot.org/uniprot/F6VQ31 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:GRM2 ^@ http://purl.uniprot.org/uniprot/F6YQJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:POLR1E ^@ http://purl.uniprot.org/uniprot/A0A9L0TDJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/9796:FAM162B ^@ http://purl.uniprot.org/uniprot/F7B149 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/9796:LOC100062428 ^@ http://purl.uniprot.org/uniprot/A0A9L0SS80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9796:SLC10A2 ^@ http://purl.uniprot.org/uniprot/F7A9H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9796:CDC20B ^@ http://purl.uniprot.org/uniprot/A0A9L0SUM4 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9796:SYCE1L ^@ http://purl.uniprot.org/uniprot/A0A5F5PK50 ^@ Similarity ^@ Belongs to the SYCE family. http://togogenome.org/gene/9796:LOC100073108 ^@ http://purl.uniprot.org/uniprot/F7AXD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9796:MET ^@ http://purl.uniprot.org/uniprot/Q2QLA9 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2 (By similarity).|||Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity. Interacts with tensin TNS3 (By similarity). Interacts (when phosphorylated) with tensin TNS4 (via SH2 domain); the interaction increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation (By similarity).|||In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity (By similarity).|||Membrane|||O-mannosylation of IPT/TIG domains by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.|||Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).|||The beta-propeller Sema domain mediates binding to HGF.|||The kinase domain is involved in SPSB1 binding.|||Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity). http://togogenome.org/gene/9796:ACTA1 ^@ http://purl.uniprot.org/uniprot/A0A090BWQ4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:TAS2R7 ^@ http://purl.uniprot.org/uniprot/F6YL32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9796:ADRA1A ^@ http://purl.uniprot.org/uniprot/F6UTQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9796:LOC100062128 ^@ http://purl.uniprot.org/uniprot/A0A9L0SQE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MTHFR ^@ http://purl.uniprot.org/uniprot/A0A9L0TH02 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/9796:AVPR1B ^@ http://purl.uniprot.org/uniprot/F7BNU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/9796:ADRA2B ^@ http://purl.uniprot.org/uniprot/A0A2C9CWS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.|||Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PAM ^@ http://purl.uniprot.org/uniprot/Q28390 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 2 Cu(2+) ions per subunit.|||Binds one Zn(2+) ion per subunit.|||In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.|||In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/9796:NSUN2 ^@ http://purl.uniprot.org/uniprot/F6X1V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/9796:STOML2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SFY1|||http://purl.uniprot.org/uniprot/F6R2L2 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9796:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/Q2QLA2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.|||Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.|||cell cortex|||dendritic spine http://togogenome.org/gene/9796:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LUI4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9796:SLC30A10 ^@ http://purl.uniprot.org/uniprot/F6QZA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9796:POU3F4 ^@ http://purl.uniprot.org/uniprot/F6T3Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/9796:ADGRL4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LPG7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L3K4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9796:CCT6B ^@ http://purl.uniprot.org/uniprot/A0A9L0TN92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9796:ITPRIP ^@ http://purl.uniprot.org/uniprot/A0A9L0SLZ2|||http://purl.uniprot.org/uniprot/F7B7M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/9796:CLN3 ^@ http://purl.uniprot.org/uniprot/F6R2F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9796:POLD3 ^@ http://purl.uniprot.org/uniprot/A6P7L4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:CTPS2 ^@ http://purl.uniprot.org/uniprot/F6R9E2 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9796:LOC100054259 ^@ http://purl.uniprot.org/uniprot/F7AC01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 11 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9796:CCDC47 ^@ http://purl.uniprot.org/uniprot/F7CNB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9796:NGB ^@ http://purl.uniprot.org/uniprot/A0A3Q2HPU5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9796:LOC100070660 ^@ http://purl.uniprot.org/uniprot/F7A6P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ZFP36L1 ^@ http://purl.uniprot.org/uniprot/F7AV26 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/9796:CPA6 ^@ http://purl.uniprot.org/uniprot/F6ZC58 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9796:SLC17A4 ^@ http://purl.uniprot.org/uniprot/F7C271 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:SUCNR1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RJU5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LBL4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:DEFB126 ^@ http://purl.uniprot.org/uniprot/F7BFE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9796:TNFSF15 ^@ http://purl.uniprot.org/uniprot/A0A0U5J7L1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9796:SLC4A11 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GVN2|||http://purl.uniprot.org/uniprot/A0A9L0SE87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:TSPAN8 ^@ http://purl.uniprot.org/uniprot/H9H043 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9796:TSSK4 ^@ http://purl.uniprot.org/uniprot/A0A9L0TBC0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:THOC2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWC8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THOC2 family.|||Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.|||Nucleus http://togogenome.org/gene/9796:ZFYVE27 ^@ http://purl.uniprot.org/uniprot/A0A9L0R1Q7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||growth cone membrane http://togogenome.org/gene/9796:MID2 ^@ http://purl.uniprot.org/uniprot/F6SD61 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9796:AWAT2 ^@ http://purl.uniprot.org/uniprot/F6TSU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9796:CD27 ^@ http://purl.uniprot.org/uniprot/F7BWA6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ECATH-2 ^@ http://purl.uniprot.org/uniprot/O62841 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9796:LOC100064785 ^@ http://purl.uniprot.org/uniprot/A0A5F5PWR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9796:SLCO1A2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RD29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:CMC4 ^@ http://purl.uniprot.org/uniprot/A0A5F5PPG3 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9796:APH1A ^@ http://purl.uniprot.org/uniprot/A0A9L0TG35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9796:LOC100068026 ^@ http://purl.uniprot.org/uniprot/F6SNT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9796:ETFRF1 ^@ http://purl.uniprot.org/uniprot/F7AB18 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9796:CDH19 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I9J3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:SERPINB10 ^@ http://purl.uniprot.org/uniprot/B8K249 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:SLC13A4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GY13|||http://purl.uniprot.org/uniprot/A0A3Q2KLB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9796:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HHS6|||http://purl.uniprot.org/uniprot/A0A9L0T774 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/9796:OVOL1 ^@ http://purl.uniprot.org/uniprot/F7AYE5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100071582 ^@ http://purl.uniprot.org/uniprot/A0A9L0RDX4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit F family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9796:RAB3A ^@ http://purl.uniprot.org/uniprot/F6VA27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9796:LOC100072092 ^@ http://purl.uniprot.org/uniprot/F7B072 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PSMB2 ^@ http://purl.uniprot.org/uniprot/F6WL01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:BRCC3 ^@ http://purl.uniprot.org/uniprot/A0A9R1SBX1|||http://purl.uniprot.org/uniprot/F6YDI4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9796:LOC100053994 ^@ http://purl.uniprot.org/uniprot/F7B9F5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:RASGRP3 ^@ http://purl.uniprot.org/uniprot/F6QDS7 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9796:BARX2 ^@ http://purl.uniprot.org/uniprot/F7CBI3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PIH1D1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HR08 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9796:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/F7AL43 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9796:LOC100068732 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GU83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:HTR2A ^@ http://purl.uniprot.org/uniprot/Q0EAB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/9796:PTGFR ^@ http://purl.uniprot.org/uniprot/Q0H0G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:KEF40_p05 ^@ http://purl.uniprot.org/uniprot/P48658|||http://purl.uniprot.org/uniprot/Q6J6W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:POU1F1 ^@ http://purl.uniprot.org/uniprot/F6X4N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9796:FTH1 ^@ http://purl.uniprot.org/uniprot/Q8MIP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ferritin family.|||Cytoplasm|||Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.|||Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis (By similarity). Has ferroxidase activity (By similarity). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). http://togogenome.org/gene/9796:CUL4B ^@ http://purl.uniprot.org/uniprot/A0A9L0SKD2 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9796:LOC100068603 ^@ http://purl.uniprot.org/uniprot/L8B938 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:FIS1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H7N6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/9796:CXCL10 ^@ http://purl.uniprot.org/uniprot/B1AB90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9796:PAQR8 ^@ http://purl.uniprot.org/uniprot/F6SKF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9796:RPL27A ^@ http://purl.uniprot.org/uniprot/A0A9L0TH67 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9796:VARS2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RF39 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9796:PON2 ^@ http://purl.uniprot.org/uniprot/F6R1T9 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9796:S100A6 ^@ http://purl.uniprot.org/uniprot/O77691 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the S-100 family.|||Cell membrane|||Cytoplasm|||Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with TPPP; this interaction inhibits TPPP dimerization (By similarity).|||May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).|||Nucleus envelope http://togogenome.org/gene/9796:SAXO1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PLW0 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/9796:DPY19L4 ^@ http://purl.uniprot.org/uniprot/F6YKF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9796:CAPZB ^@ http://purl.uniprot.org/uniprot/A0A9L0SJ58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/9796:MRPL27 ^@ http://purl.uniprot.org/uniprot/F6YHM1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9796:TJAP1 ^@ http://purl.uniprot.org/uniprot/F6Q2V5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:RIDA ^@ http://purl.uniprot.org/uniprot/F7A6J6 ^@ Function|||Similarity ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. http://togogenome.org/gene/9796:RPS6KB2 ^@ http://purl.uniprot.org/uniprot/F6Q7I1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:FAM49B ^@ http://purl.uniprot.org/uniprot/A0A9L0T5R3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9796:LZTS2 ^@ http://purl.uniprot.org/uniprot/F6ZIR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTS2 family.|||Cytoplasm|||Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.|||Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.|||centrosome http://togogenome.org/gene/9796:LOC102147773 ^@ http://purl.uniprot.org/uniprot/A0A9L0RJG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CDIPT ^@ http://purl.uniprot.org/uniprot/A0A9L0TAQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9796:RBL1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HLF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/9796:LOC100067067 ^@ http://purl.uniprot.org/uniprot/F7AZC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TBX20 ^@ http://purl.uniprot.org/uniprot/F7CIF3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9796:DUOX2 ^@ http://purl.uniprot.org/uniprot/F6QB25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.|||In the N-terminal section; belongs to the peroxidase family.|||Membrane http://togogenome.org/gene/9796:SEC23A ^@ http://purl.uniprot.org/uniprot/A0A3Q2H5Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9796:CEP44 ^@ http://purl.uniprot.org/uniprot/A0A9L0TEV9 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/9796:MRPL16 ^@ http://purl.uniprot.org/uniprot/A0A9L0SBI8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9796:EFNB2 ^@ http://purl.uniprot.org/uniprot/B0LDS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:TFEB ^@ http://purl.uniprot.org/uniprot/F7E1U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9796:LOC100629900 ^@ http://purl.uniprot.org/uniprot/F6VQX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:HBZ ^@ http://purl.uniprot.org/uniprot/P13787 ^@ Function|||Similarity|||Subunit ^@ Belongs to the globin family.|||Heterotetramer of two zeta chains and beta-type chains.|||The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. http://togogenome.org/gene/9796:WARS ^@ http://purl.uniprot.org/uniprot/A0A9L0R368 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9796:HARBI1 ^@ http://purl.uniprot.org/uniprot/F6Z2K8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9796:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HX30|||http://purl.uniprot.org/uniprot/A0A9L0SIQ6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:GYS1 ^@ http://purl.uniprot.org/uniprot/B2L109 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/9796:C13H16orf58 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HYF7 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/9796:GLIPR1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ILZ8 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9796:GTF2A1L ^@ http://purl.uniprot.org/uniprot/A0A9L0T1K9|||http://purl.uniprot.org/uniprot/F6QVL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9796:ADCY8 ^@ http://purl.uniprot.org/uniprot/F6R859 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9796:SCN7A ^@ http://purl.uniprot.org/uniprot/A0A9R1SHJ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9796:CHST11 ^@ http://purl.uniprot.org/uniprot/F7E238 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:EIF3H ^@ http://purl.uniprot.org/uniprot/K9K4A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9796:TRMT5 ^@ http://purl.uniprot.org/uniprot/F7D5D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/9796:LOC100069078 ^@ http://purl.uniprot.org/uniprot/F6U0U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100629535 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HNA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CYB5RL ^@ http://purl.uniprot.org/uniprot/A0A3Q2I724 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9796:NDUFB9 ^@ http://purl.uniprot.org/uniprot/F7CIH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:CDKL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SPN8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:TMEM230 ^@ http://purl.uniprot.org/uniprot/F6PLK7|||http://purl.uniprot.org/uniprot/K9KEK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9796:PRKAB2 ^@ http://purl.uniprot.org/uniprot/Q2LGF6 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9796:NCBP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GT55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/9796:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H2G4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:TWIST1 ^@ http://purl.uniprot.org/uniprot/A0A1W5 ^@ Function ^@ Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer. http://togogenome.org/gene/9796:PRRC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SC92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/9796:ANAPC16 ^@ http://purl.uniprot.org/uniprot/F6W110 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/9796:CYP2E1 ^@ http://purl.uniprot.org/uniprot/A8WDL7|||http://purl.uniprot.org/uniprot/F7DJ72 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.|||Membrane|||Microsome membrane|||Mitochondrion inner membrane|||The omega-1 hydroxylase activity is stimulated by cytochrome b5. http://togogenome.org/gene/9796:INPP5D ^@ http://purl.uniprot.org/uniprot/F7BUY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane http://togogenome.org/gene/9796:LOC102150892 ^@ http://purl.uniprot.org/uniprot/A0A9L0TP34 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9796:STX19 ^@ http://purl.uniprot.org/uniprot/F6UAH4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9796:SLC27A2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RCP3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9796:ACADVL ^@ http://purl.uniprot.org/uniprot/A0A3Q2H2J1|||http://purl.uniprot.org/uniprot/A0A9L0RHP5|||http://purl.uniprot.org/uniprot/F6PJ47 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9796:FAM193A ^@ http://purl.uniprot.org/uniprot/A0A9L0RW71 ^@ Similarity ^@ Belongs to the FAM193 family. http://togogenome.org/gene/9796:KIF9 ^@ http://purl.uniprot.org/uniprot/A0A9L0R605|||http://purl.uniprot.org/uniprot/A0A9L0S338|||http://purl.uniprot.org/uniprot/A0A9L0T487 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9796:LOC106781413 ^@ http://purl.uniprot.org/uniprot/F6TM11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ENTPD5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I7T6|||http://purl.uniprot.org/uniprot/A0A9L0SU27 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9796:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HIC5|||http://purl.uniprot.org/uniprot/A0A5F5PHV0|||http://purl.uniprot.org/uniprot/F6VYP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9796:CLK4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GV39|||http://purl.uniprot.org/uniprot/A0A9L0SWB4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:MARCH4 ^@ http://purl.uniprot.org/uniprot/F7E1M2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100068543 ^@ http://purl.uniprot.org/uniprot/A0A5F5PQ60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:AMIGO3 ^@ http://purl.uniprot.org/uniprot/F6SQI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9796:OAZ2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RX18 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9796:CYP2D50 ^@ http://purl.uniprot.org/uniprot/A8W4X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:LOC100061458 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I6F9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:SLC2A2 ^@ http://purl.uniprot.org/uniprot/Q6KBW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:BABAM2 ^@ http://purl.uniprot.org/uniprot/F6STU2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/9796:RARB ^@ http://purl.uniprot.org/uniprot/A0A9L0R765 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9796:NOP10 ^@ http://purl.uniprot.org/uniprot/F6PRC7 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9796:GDF5 ^@ http://purl.uniprot.org/uniprot/F7BKJ7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9796:LOC100054250 ^@ http://purl.uniprot.org/uniprot/F6TUS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:KARS ^@ http://purl.uniprot.org/uniprot/A0A5F5PL33|||http://purl.uniprot.org/uniprot/F6ZYC2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9796:ZFHX2 ^@ http://purl.uniprot.org/uniprot/F6ZYQ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:GLRA4 ^@ http://purl.uniprot.org/uniprot/F6RNW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9796:SLC30A3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SF64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9796:LOC100072158 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KXD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MID1IP1 ^@ http://purl.uniprot.org/uniprot/F6XDI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:CTSE ^@ http://purl.uniprot.org/uniprot/A0A9L0T0M1 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9796:RLN ^@ http://purl.uniprot.org/uniprot/P22969 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.|||Secreted http://togogenome.org/gene/9796:MPZ ^@ http://purl.uniprot.org/uniprot/Q6WEB5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the myelin P0 protein family.|||Cell membrane|||Homodimer and homotetramer.|||Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.|||N-glycosylated; contains sulfate-substituted glycan. http://togogenome.org/gene/9796:LOC100146413 ^@ http://purl.uniprot.org/uniprot/A0A9L0RU92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:GOLPH3L ^@ http://purl.uniprot.org/uniprot/F6X7B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9796:MBOAT1 ^@ http://purl.uniprot.org/uniprot/F7BN22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:PRL ^@ http://purl.uniprot.org/uniprot/A0A0M6L0Z4|||http://purl.uniprot.org/uniprot/P12420 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the somatotropin/prolactin family.|||Interacts with PRLR.|||Prolactin acts primarily on the mammary gland by promoting lactation.|||Secreted http://togogenome.org/gene/9796:LOC100068040 ^@ http://purl.uniprot.org/uniprot/F6UR32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ADGRG5 ^@ http://purl.uniprot.org/uniprot/F6TIA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HT91|||http://purl.uniprot.org/uniprot/F6PRV8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9796:KCNH8 ^@ http://purl.uniprot.org/uniprot/F6TKX5 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9796:LAMP2 ^@ http://purl.uniprot.org/uniprot/F6ZAT6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9796:LOC100054397 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I536 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:HMGCS2 ^@ http://purl.uniprot.org/uniprot/F7CBP9 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9796:IFI27 ^@ http://purl.uniprot.org/uniprot/F6WPD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9796:STMN1 ^@ http://purl.uniprot.org/uniprot/K9K1Z1 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9796:RAB9A ^@ http://purl.uniprot.org/uniprot/F6QIK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9796:SLC51A ^@ http://purl.uniprot.org/uniprot/A0A9L0SSC0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ACVR1 ^@ http://purl.uniprot.org/uniprot/F7B4G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9796:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GYZ8|||http://purl.uniprot.org/uniprot/F6WNW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/9796:GUCA2B ^@ http://purl.uniprot.org/uniprot/F6S6Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9796:ANP32E ^@ http://purl.uniprot.org/uniprot/A0A5F5PWG1|||http://purl.uniprot.org/uniprot/K9KAG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9796:KMO ^@ http://purl.uniprot.org/uniprot/A0A9L0T1P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.|||Mitochondrion outer membrane http://togogenome.org/gene/9796:CCS ^@ http://purl.uniprot.org/uniprot/A0A9L0R7W9 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/9796:PSMB6 ^@ http://purl.uniprot.org/uniprot/F6W2I4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:CCNC ^@ http://purl.uniprot.org/uniprot/A0A3Q2I6R9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9796:TMEM2 ^@ http://purl.uniprot.org/uniprot/F6Z4U0 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9796:PPIL1 ^@ http://purl.uniprot.org/uniprot/F6ZB40 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9796:CPSF4 ^@ http://purl.uniprot.org/uniprot/A0A9L0RRJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9796:LOC100070849 ^@ http://purl.uniprot.org/uniprot/F7AWE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MTMR3 ^@ http://purl.uniprot.org/uniprot/F7CGU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9796:UGDH ^@ http://purl.uniprot.org/uniprot/A0A9L0TG41 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/9796:MRPL42 ^@ http://purl.uniprot.org/uniprot/A0A9L0T5S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/9796:GLIPR1L1 ^@ http://purl.uniprot.org/uniprot/F6TDU6 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9796:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A9L0S8H1 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9796:LOC100054406 ^@ http://purl.uniprot.org/uniprot/A0A5F5PEZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ACTR6 ^@ http://purl.uniprot.org/uniprot/A0A9L0S3J5|||http://purl.uniprot.org/uniprot/F7AZA0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:LOC100061154 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HQ75 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9796:HSD17B11 ^@ http://purl.uniprot.org/uniprot/A0A9R1SEY9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:WNT8A ^@ http://purl.uniprot.org/uniprot/A0A9L0SZV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9796:HGF ^@ http://purl.uniprot.org/uniprot/A0A9L0SA83 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. http://togogenome.org/gene/9796:KIF2B ^@ http://purl.uniprot.org/uniprot/F6W9I6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9796:FN3KRP ^@ http://purl.uniprot.org/uniprot/F7BHX5 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9796:ATP6V1D ^@ http://purl.uniprot.org/uniprot/F6SBI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9796:FRK ^@ http://purl.uniprot.org/uniprot/F6RRJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:KIF15 ^@ http://purl.uniprot.org/uniprot/A0A9L0TB14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.|||spindle http://togogenome.org/gene/9796:TBC1D7 ^@ http://purl.uniprot.org/uniprot/F6WQA7 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9796:SAR1A ^@ http://purl.uniprot.org/uniprot/F7BD89 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9796:GSDME ^@ http://purl.uniprot.org/uniprot/Q7YS54 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gasdermin family.|||Cell membrane|||Cleavage at Asp-270 by CASP3 (mature and uncleaved precursor forms) or granzyme B (GZMB) relieves autoinhibition and is sufficient to initiate pyroptosis.|||Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane.|||Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain, that is released upon cleavage by CASP3 or granzyme B (GZMB).|||Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively. After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukins (IL1B and IL16) and triggering pyroptosis. Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity. Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity. Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells: cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, triggers pyroptosis of tumor cells and tumor suppression. May play a role in the p53/TP53-regulated cellular response to DNA damage.|||Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis.|||Succination by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits processing by caspases, and ability to initiate pyroptosis. Succination modification is catalyzed by a non-enzymatic reaction caused by an accumulation of fumarate.|||The full-length protein before cleavage is inactive: intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-E, N-terminal) following cleavage by CASP3 or granzyme B (GZMB). Activated by NLRP1 in the absence of GSDMD expression: NLRP1 cleaves and activates CASP8, promoting downstream activation of CASP3 and subsequent activation of GSDME.|||cytosol http://togogenome.org/gene/9796:ITGA2B ^@ http://purl.uniprot.org/uniprot/Q7YRP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9796:CLSTN3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T6R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/9796:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A5F5PX34|||http://purl.uniprot.org/uniprot/F6QAI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9796:SEC24D ^@ http://purl.uniprot.org/uniprot/F7A9B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9796:FIGNL1 ^@ http://purl.uniprot.org/uniprot/F6X5F5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9796:FAM174A ^@ http://purl.uniprot.org/uniprot/A0A0D3QJ19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9796:FUNDC2 ^@ http://purl.uniprot.org/uniprot/F6RA93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9796:LOC100072608 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZQ0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TRUB1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RGX8 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/9796:TTR ^@ http://purl.uniprot.org/uniprot/F6UL68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/9796:KCNQ1 ^@ http://purl.uniprot.org/uniprot/W5UPJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum|||Lateral cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/9796:NDC80 ^@ http://purl.uniprot.org/uniprot/F6XIY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9796:LOC100063525 ^@ http://purl.uniprot.org/uniprot/A0A9L0S2B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100050322 ^@ http://purl.uniprot.org/uniprot/F7DZD2 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/9796:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/F6X3L0 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9796:LOC100068670 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HDV9|||http://purl.uniprot.org/uniprot/F7DJW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:MC1R ^@ http://purl.uniprot.org/uniprot/P79166 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.|||Receptor for MSH (alpha, beta and gamma) and ACTH (By similarity). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity). http://togogenome.org/gene/9796:BSX ^@ http://purl.uniprot.org/uniprot/A0A3Q2HP15 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:UCHL1 ^@ http://purl.uniprot.org/uniprot/Q9GM50 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C12 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.|||Monomer. Homodimer. Interacts with COPS5 and SNCA (By similarity).|||O-glycosylated.|||The homodimer may have ATP-independent ubiquitin ligase activity. However, in another study, UCHL1 was shown to lack ubiquitin ligase activity.|||Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity). http://togogenome.org/gene/9796:TMEM53 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q4B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/9796:ADGRG7 ^@ http://purl.uniprot.org/uniprot/F6YF06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:PEBP1 ^@ http://purl.uniprot.org/uniprot/F6QXW2 ^@ Similarity ^@ Belongs to the phosphatidylethanolamine-binding protein family. http://togogenome.org/gene/9796:LOC100059515 ^@ http://purl.uniprot.org/uniprot/F6WV74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PINLYP ^@ http://purl.uniprot.org/uniprot/A0A9L0RJ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/9796:LYRM1 ^@ http://purl.uniprot.org/uniprot/K9KED2 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9796:CSNK2B ^@ http://purl.uniprot.org/uniprot/F6UJ03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/9796:TMBIM7P ^@ http://purl.uniprot.org/uniprot/A0A9L0S8U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9796:RNASE10 ^@ http://purl.uniprot.org/uniprot/Q70IB3|||http://purl.uniprot.org/uniprot/W0UVF8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the pancreatic ribonuclease family.|||Male-specific expression in proximal caput of the epididymis.|||Secreted|||Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).|||The N-terminus is blocked. Glycosylated (By similarity). http://togogenome.org/gene/9796:LOC100072073 ^@ http://purl.uniprot.org/uniprot/F7D0K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NECAP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R7C5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9796:RPL30 ^@ http://purl.uniprot.org/uniprot/F6YBQ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/9796:TRIP12 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q2W1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||nucleoplasm http://togogenome.org/gene/9796:RARS2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TIR8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9796:CD79A ^@ http://purl.uniprot.org/uniprot/A0A9L0SFR1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:SMIM18 ^@ http://purl.uniprot.org/uniprot/A0A9L0SBY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CES2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RXX4 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9796:CHGA ^@ http://purl.uniprot.org/uniprot/Q9XS63 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the chromogranin/secretogranin protein family.|||Binds calcium with a low-affinity.|||Highly expressed in adrenal medulla and pituitary gland. Weaker expression detected in cerebrum, cerebellum, spinal cord, liver, thyroid gland, striated muscle, lung, spleen, kidney, parotid gland, and sublingual gland.|||Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.|||O-glycosylated; contains chondroitin sulfate (CS). CS attachment is pH-dependent, being observed at mildly acidic conditions of pH 5 but not at neutral pH, and promotes self-assembly in vitro.|||Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.|||Secreted|||Self-interacts; self-assembly is promoted in vitro by chondroitin sulfate attachment which occurs at mildly acidic pH conditions (By similarity). Interacts with SCG3 (By similarity).|||Strongly inhibits glucose induced insulin release from the pancreas.|||neuronal dense core vesicle|||secretory vesicle http://togogenome.org/gene/9796:HPSE ^@ http://purl.uniprot.org/uniprot/F7BXT6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9796:BCS1L ^@ http://purl.uniprot.org/uniprot/A0A9L0S3Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:NPHS2 ^@ http://purl.uniprot.org/uniprot/F6WST7 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9796:CLCN6 ^@ http://purl.uniprot.org/uniprot/F6VRQ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:SCGN ^@ http://purl.uniprot.org/uniprot/F6VXU6 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/9796:MLH3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SM39 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/9796:MHCX1 ^@ http://purl.uniprot.org/uniprot/Q30488 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:LPL ^@ http://purl.uniprot.org/uniprot/A0A3Q2HYC4 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9796:MFRP ^@ http://purl.uniprot.org/uniprot/F6Q3D3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:TIMP4 ^@ http://purl.uniprot.org/uniprot/F7BMM7 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9796:LOC100053105 ^@ http://purl.uniprot.org/uniprot/A0A9L0R372 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:RAG1 ^@ http://purl.uniprot.org/uniprot/F6WSB4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/9796:SLC5A4 ^@ http://purl.uniprot.org/uniprot/F6XI49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100052276 ^@ http://purl.uniprot.org/uniprot/A0A9L0TJJ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:MTCH2 ^@ http://purl.uniprot.org/uniprot/A0A9R1SS99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:CDKL4 ^@ http://purl.uniprot.org/uniprot/A0A9L0STU3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:TACR1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T4S8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9796:LOC100067520 ^@ http://purl.uniprot.org/uniprot/F6U3T0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PSAPL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T7Q4 ^@ Function|||Subcellular Location Annotation ^@ May activate the lysosomal degradation of sphingolipids.|||Secreted http://togogenome.org/gene/9796:GRK1 ^@ http://purl.uniprot.org/uniprot/F6TZY4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9796:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZP7|||http://purl.uniprot.org/uniprot/A0A3Q2KSF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PSMA8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SVS6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9796:EEF1D ^@ http://purl.uniprot.org/uniprot/A0A9L0TMX3|||http://purl.uniprot.org/uniprot/A0A9L0TU59 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/9796:RPS24 ^@ http://purl.uniprot.org/uniprot/A0A5F5PPH2|||http://purl.uniprot.org/uniprot/A0A5F5PYV3|||http://purl.uniprot.org/uniprot/F6Z3G3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/9796:SLC17A3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RJ88|||http://purl.uniprot.org/uniprot/F6V7R5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:F13A1 ^@ http://purl.uniprot.org/uniprot/F6UZI2 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9796:LOC100054358 ^@ http://purl.uniprot.org/uniprot/A0A9L0RGD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9796:LOC100054216 ^@ http://purl.uniprot.org/uniprot/F7DL96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 11 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9796:AMPD3 ^@ http://purl.uniprot.org/uniprot/F6V9E7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9796:NR5A1 ^@ http://purl.uniprot.org/uniprot/Q9GKL2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation stimulates the transcriptional activity.|||Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NR0B2. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3 (By similarity).|||Nucleus|||Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity).|||Sumoylation reduces CDK7-mediated phosphorylation on Ser-203.|||Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity). http://togogenome.org/gene/9796:SNX33 ^@ http://purl.uniprot.org/uniprot/F6TMS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9796:LOC100629661 ^@ http://purl.uniprot.org/uniprot/A0A9L0QZA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CYP3A93 ^@ http://purl.uniprot.org/uniprot/D7GB55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:ABCG5 ^@ http://purl.uniprot.org/uniprot/F7BX14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9796:AKAP3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HIA1 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9796:VSX2 ^@ http://purl.uniprot.org/uniprot/F6YMZ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:MRAP ^@ http://purl.uniprot.org/uniprot/A0A9L0T966 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:LOC100055179 ^@ http://purl.uniprot.org/uniprot/F7AM91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9796:CCT5 ^@ http://purl.uniprot.org/uniprot/F6UH83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/9796:GRB10 ^@ http://purl.uniprot.org/uniprot/F6XRD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9796:THRSP ^@ http://purl.uniprot.org/uniprot/F7AMU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:NT5C3A ^@ http://purl.uniprot.org/uniprot/F6U9S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9796:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HFJ3|||http://purl.uniprot.org/uniprot/A0A9L0TPB0|||http://purl.uniprot.org/uniprot/A7LHD8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.|||Secreted http://togogenome.org/gene/9796:LOC102149062 ^@ http://purl.uniprot.org/uniprot/F7C9U5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9796:CS ^@ http://purl.uniprot.org/uniprot/Q0QEK7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the citrate synthase family.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/9796:EDN1 ^@ http://purl.uniprot.org/uniprot/F7APB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9796:LOC106781531 ^@ http://purl.uniprot.org/uniprot/A0A9L0SRI1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9796:STAMBPL1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HNG7|||http://purl.uniprot.org/uniprot/F6VUG1 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9796:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/A0A9R1SI93 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9796:FGD2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KLD1|||http://purl.uniprot.org/uniprot/F6ZQC1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9796:CNTN1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I6U4 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9796:SETD3 ^@ http://purl.uniprot.org/uniprot/F7D116 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm|||Interacts with MYOD1. http://togogenome.org/gene/9796:GATB ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4T3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9796:FAM135B ^@ http://purl.uniprot.org/uniprot/F6ZLZ7 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9796:RPL7L1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SH89 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/9796:SEMA4D ^@ http://purl.uniprot.org/uniprot/F6PIU6 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:DPYSL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SPS8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9796:PSMB10 ^@ http://purl.uniprot.org/uniprot/A0A9L0R065|||http://purl.uniprot.org/uniprot/F6SZ35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:PLA2G2A ^@ http://purl.uniprot.org/uniprot/A3RLX2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9796:LOC100054366 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HPZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9796:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/F6PHP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9796:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HVA9|||http://purl.uniprot.org/uniprot/A0A9L0RHN8|||http://purl.uniprot.org/uniprot/A0A9L0RJ73 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9796:VWCE ^@ http://purl.uniprot.org/uniprot/F7DGC5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:OCIAD1 ^@ http://purl.uniprot.org/uniprot/F6S1L5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9796:PPRC1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4M6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:KEF40_p09 ^@ http://purl.uniprot.org/uniprot/P48663|||http://purl.uniprot.org/uniprot/Q6J6X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/9796:ATF1 ^@ http://purl.uniprot.org/uniprot/F6YIC3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:AMT ^@ http://purl.uniprot.org/uniprot/A0A5F5PL15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9796:CCL25 ^@ http://purl.uniprot.org/uniprot/A0A9L0SH37 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9796:TNFSF4 ^@ http://purl.uniprot.org/uniprot/A0A0U5J7G1|||http://purl.uniprot.org/uniprot/F6UJR4 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9796:JRK ^@ http://purl.uniprot.org/uniprot/F6ZFV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:EIF6 ^@ http://purl.uniprot.org/uniprot/A0A9R1SSZ9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/9796:DEFB127 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GUX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9796:SH3RF2 ^@ http://purl.uniprot.org/uniprot/F6YV64 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/9796:TMEFF2 ^@ http://purl.uniprot.org/uniprot/F6VIK8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC100049859 ^@ http://purl.uniprot.org/uniprot/A0A9L0TSP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MOZART2 family.|||centrosome|||spindle http://togogenome.org/gene/9796:CALCB ^@ http://purl.uniprot.org/uniprot/Q9N0T3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (By similarity).|||Secreted http://togogenome.org/gene/9796:FAM57B ^@ http://purl.uniprot.org/uniprot/A0A9L0RQW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:STX11 ^@ http://purl.uniprot.org/uniprot/F7CD26 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9796:DUSP4 ^@ http://purl.uniprot.org/uniprot/F6QIN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9796:MTRF1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TGT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9796:OPN5 ^@ http://purl.uniprot.org/uniprot/A0A9L0QXD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9796:TM4SF20 ^@ http://purl.uniprot.org/uniprot/F6S942 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9796:FAM166A ^@ http://purl.uniprot.org/uniprot/F6ZE89 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9796:ZDHHC14 ^@ http://purl.uniprot.org/uniprot/A0A9L0RTE0|||http://purl.uniprot.org/uniprot/A0A9L0SNF5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9796:LOC100065729 ^@ http://purl.uniprot.org/uniprot/F6Z2U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9796:LOC100070501 ^@ http://purl.uniprot.org/uniprot/F6S6G0 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9796:PDE1C ^@ http://purl.uniprot.org/uniprot/A0A5F5PIR4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9796:FAM96B ^@ http://purl.uniprot.org/uniprot/F7DB83 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/9796:TAZ ^@ http://purl.uniprot.org/uniprot/A0A3Q2HJJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9796:CDCA8 ^@ http://purl.uniprot.org/uniprot/F6TAI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the borealin family.|||centromere http://togogenome.org/gene/9796:PPIL4 ^@ http://purl.uniprot.org/uniprot/F6YB81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9796:SLC29A2 ^@ http://purl.uniprot.org/uniprot/F7AL58 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100062650 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GY19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/9796:REC8 ^@ http://purl.uniprot.org/uniprot/F6Q4S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9796:NUDT7 ^@ http://purl.uniprot.org/uniprot/A0A9L0TBA4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9796:UTS2R ^@ http://purl.uniprot.org/uniprot/F6RZK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/9796:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A7U3L4J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9796:OSBPL6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HMI2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9796:HCFC1 ^@ http://purl.uniprot.org/uniprot/F6TVL2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:HVCN1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TR54 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9796:ATG4A ^@ http://purl.uniprot.org/uniprot/A0A9L0RXE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9796:CYCS ^@ http://purl.uniprot.org/uniprot/F7D4V9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9796:MOSPD3 ^@ http://purl.uniprot.org/uniprot/F6Y324 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100067529 ^@ http://purl.uniprot.org/uniprot/F6VXS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MED1 ^@ http://purl.uniprot.org/uniprot/F6XFN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9796:SLC47A2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SQK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/9796:ATP7A ^@ http://purl.uniprot.org/uniprot/A0A9L0SAF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9796:NTF3 ^@ http://purl.uniprot.org/uniprot/A0A9L0THK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/9796:LOC100067391 ^@ http://purl.uniprot.org/uniprot/F6U7A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MAOA ^@ http://purl.uniprot.org/uniprot/Q5NU32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flavin monoamine oxidase family.|||Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.|||Mitochondrion outer membrane|||Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity). http://togogenome.org/gene/9796:RNF121 ^@ http://purl.uniprot.org/uniprot/F6QT59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:NLK ^@ http://purl.uniprot.org/uniprot/A0A9L0SWH6 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9796:SLC5A10 ^@ http://purl.uniprot.org/uniprot/A0A5F5PL77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:ANP32A ^@ http://purl.uniprot.org/uniprot/A0A3Q2LEQ7|||http://purl.uniprot.org/uniprot/A0A9L0SB15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9796:DMRT3 ^@ http://purl.uniprot.org/uniprot/F6W2R2 ^@ Domain|||Function|||Miscellaneous|||Polymorphism|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the DMRT family.|||DMA domain interacts with ubiquitin.|||DMRT3 is a marker for a subset of spinal cord neurons (dI6).|||Expressed in the spinal cord, in a small population of neurons located in the ventral horn and around the central canal.|||Nucleus|||Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.|||This sequence corresponds to the wild-type form. A truncated allele, allele A (AC J7FCF0), is linked to the ability to perform alternate gaits, which can be either pace or four-beat ambling gaits. The allele A sequence (AC J7FCF0) has a favorable effect on harness racing performance and on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation. Homozygosity for the mutation is required, but not sufficient for pacing, as many Standardbred trotters and some Icelandic horses that are homozygous for this mutation do not pace. The allele A is not found in the following horse populations: Arabian horse, Gotland pony, North-Swedish draft horse, Przewalski's horse, Shetland pony, Swedish ardennes, Swedish warmblood and Thoroughbred. http://togogenome.org/gene/9796:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TR35|||http://purl.uniprot.org/uniprot/F7B8J6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9796:SLC12A7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L260 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9796:LOC100072616 ^@ http://purl.uniprot.org/uniprot/A0A5F5PGC0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:APOOL ^@ http://purl.uniprot.org/uniprot/K9K206 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:TXNL4A ^@ http://purl.uniprot.org/uniprot/L7MRR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9796:CENPN ^@ http://purl.uniprot.org/uniprot/A0A9L0SFK9|||http://purl.uniprot.org/uniprot/F6TTV5 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/9796:LOC100068151 ^@ http://purl.uniprot.org/uniprot/F6Y7V5 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:FYTTD1 ^@ http://purl.uniprot.org/uniprot/F7B5A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UIF family.|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/9796:ALOX12B ^@ http://purl.uniprot.org/uniprot/F6PXL3 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the lipoxygenase family.|||Binds 1 Fe cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:BCAN ^@ http://purl.uniprot.org/uniprot/A0A3Q2KPZ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9796:EPN1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNH6|||http://purl.uniprot.org/uniprot/F6TQ05 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/9796:DLD ^@ http://purl.uniprot.org/uniprot/F6U3F1 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||acrosome|||flagellum http://togogenome.org/gene/9796:GALE ^@ http://purl.uniprot.org/uniprot/F6SUZ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/9796:HAX1 ^@ http://purl.uniprot.org/uniprot/K9K3F5 ^@ Function|||Similarity ^@ Belongs to the HAX1 family.|||Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. http://togogenome.org/gene/9796:NUP62 ^@ http://purl.uniprot.org/uniprot/F6Z9U7 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/9796:LOC100057935 ^@ http://purl.uniprot.org/uniprot/A0A9L0SZS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100070616 ^@ http://purl.uniprot.org/uniprot/A0A9L0RAV3 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9796:NFIB ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0H1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9796:OPA1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RBX1|||http://purl.uniprot.org/uniprot/F6Z1V1 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9796:IL1RN ^@ http://purl.uniprot.org/uniprot/O18999 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9796:CLDN14 ^@ http://purl.uniprot.org/uniprot/F7AHT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:MRM1 ^@ http://purl.uniprot.org/uniprot/F6SV11 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/9796:TMEM254 ^@ http://purl.uniprot.org/uniprot/A0A5F5PGN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC102147612 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4V1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100629331 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ICP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9796:SFR1 ^@ http://purl.uniprot.org/uniprot/F6Q466|||http://purl.uniprot.org/uniprot/F6SSL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/9796:DOCK9 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GUW6|||http://purl.uniprot.org/uniprot/A0A3Q2KY00|||http://purl.uniprot.org/uniprot/F6R1N6 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9796:LOC100053847 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HBF8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:HS3ST2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SDR2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:TTC27 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GW93|||http://purl.uniprot.org/uniprot/F6T720 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/9796:LOC100054193 ^@ http://purl.uniprot.org/uniprot/A0A9L0SR46 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:RENBP ^@ http://purl.uniprot.org/uniprot/F7B0V7 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/9796:GABRA4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:RPL26 ^@ http://purl.uniprot.org/uniprot/A0A9L0RTB5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9796:CYP19A1 ^@ http://purl.uniprot.org/uniprot/O46512 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).|||Belongs to the cytochrome P450 family.|||Clone A1 form may be a splice variant or an artifact.|||Contains a I helix thought to serve as the substrate-binding pocket.|||Endoplasmic reticulum membrane|||Expressed in placenta. Highly expressed in follicles (0 hour:hCG), followed by a drop (12-24 hour:hCG) and by an increase (30-39 hour:hCG). Highly expressed in corpora lutea. Also expressed in granulosa cell layer. Not expressed in theca interna.|||Microsome membrane http://togogenome.org/gene/9796:CCDC188 ^@ http://purl.uniprot.org/uniprot/A0A9L0T1C2|||http://purl.uniprot.org/uniprot/A0A9L0TC07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:EQUCABV1R910 ^@ http://purl.uniprot.org/uniprot/F7CA32 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:LOC100059576 ^@ http://purl.uniprot.org/uniprot/A0A9L0T653 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9796:PAG ^@ http://purl.uniprot.org/uniprot/Q28389 ^@ Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the peptidase A1 family.|||Trophoblast and placental tissue.|||extracellular space http://togogenome.org/gene/9796:PPP6R1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I1G8 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/9796:SCN3B ^@ http://purl.uniprot.org/uniprot/A0A3Q2LA13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/9796:OSBPL1A ^@ http://purl.uniprot.org/uniprot/F7CW96 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9796:GJA3 ^@ http://purl.uniprot.org/uniprot/F6U7L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:ZNF768 ^@ http://purl.uniprot.org/uniprot/F7E3U9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:CGA ^@ http://purl.uniprot.org/uniprot/A0A0F7RPW0|||http://purl.uniprot.org/uniprot/P01220 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Secreted|||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. http://togogenome.org/gene/9796:WARS2 ^@ http://purl.uniprot.org/uniprot/K9K3B1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9796:OLFM4 ^@ http://purl.uniprot.org/uniprot/F7DPZ6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LSE5|||http://purl.uniprot.org/uniprot/F7AYG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/9796:LOC100054849 ^@ http://purl.uniprot.org/uniprot/F6QCG3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SUOX ^@ http://purl.uniprot.org/uniprot/F6UC66 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.|||Mitochondrion intermembrane space http://togogenome.org/gene/9796:AREL1 ^@ http://purl.uniprot.org/uniprot/F7BTE5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC100630794 ^@ http://purl.uniprot.org/uniprot/A0A9L0RDD4 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9796:TMIGD3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HI03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9796:PPM1K ^@ http://purl.uniprot.org/uniprot/A0A9L0R2S5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9796:PEX16 ^@ http://purl.uniprot.org/uniprot/F6ZXH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/9796:UBR2 ^@ http://purl.uniprot.org/uniprot/F6U418|||http://purl.uniprot.org/uniprot/F6U471 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/9796:ENO3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RNW0|||http://purl.uniprot.org/uniprot/I3RM59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9796:ART4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SZK3 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9796:CD8A ^@ http://purl.uniprot.org/uniprot/A0A9L0RXP0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:SLC25A51 ^@ http://purl.uniprot.org/uniprot/F6SBU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:IFI44 ^@ http://purl.uniprot.org/uniprot/F6R7P0 ^@ Similarity ^@ Belongs to the IFI44 family. http://togogenome.org/gene/9796:DNAJC16 ^@ http://purl.uniprot.org/uniprot/F6T037 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/9796:HAPLN2 ^@ http://purl.uniprot.org/uniprot/F6VVF9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9796:CYSLTR1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RIF5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:EPHA4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SEZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:NKX2-2 ^@ http://purl.uniprot.org/uniprot/F7A4A4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:SERPINC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S3A7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/9796:APLNR ^@ http://purl.uniprot.org/uniprot/F6QWW0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:DAZL ^@ http://purl.uniprot.org/uniprot/F6ZZT8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:LOC100060547 ^@ http://purl.uniprot.org/uniprot/A0A9L0TN56 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9796:LOC100070809 ^@ http://purl.uniprot.org/uniprot/A0A9L0RHD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SSTR2 ^@ http://purl.uniprot.org/uniprot/A0A9L0R3Q2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/9796:BSP1 ^@ http://purl.uniprot.org/uniprot/Q70GG6 ^@ Caution|||Similarity ^@ Belongs to the seminal plasma protein family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:KEF40_p04 ^@ http://purl.uniprot.org/uniprot/P48655 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:IFNG ^@ http://purl.uniprot.org/uniprot/A0A7R8C3S7|||http://purl.uniprot.org/uniprot/P42160 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.|||Released primarily from activated T lymphocytes.|||Secreted|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).|||Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation. http://togogenome.org/gene/9796:INTS7 ^@ http://purl.uniprot.org/uniprot/A0A9L0RYB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9796:ECATH-3 ^@ http://purl.uniprot.org/uniprot/O62842 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/9796:TXK ^@ http://purl.uniprot.org/uniprot/A0A9L0TEA5|||http://purl.uniprot.org/uniprot/F6Y4C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:FBXO48 ^@ http://purl.uniprot.org/uniprot/F7A4L5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9796:TUBA8 ^@ http://purl.uniprot.org/uniprot/A0A9L0S0U6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9796:LOC100059452 ^@ http://purl.uniprot.org/uniprot/F6UM82 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9796:NRF1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TAX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRF1/Ewg family.|||Nucleus http://togogenome.org/gene/9796:LOC100069179 ^@ http://purl.uniprot.org/uniprot/A0A5F5PYT2 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9796:FGF23 ^@ http://purl.uniprot.org/uniprot/A0A7U3L5L0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:PHYHIP ^@ http://purl.uniprot.org/uniprot/A0A9L0SH78 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9796:WNT2B ^@ http://purl.uniprot.org/uniprot/A0A9L0SSH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9796:TOB2 ^@ http://purl.uniprot.org/uniprot/F7DRN7 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9796:SMIM8 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HD93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/9796:LOC100057342 ^@ http://purl.uniprot.org/uniprot/A0A5F5PHB8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:DSEL ^@ http://purl.uniprot.org/uniprot/F6SII7 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/9796:LOC100058280 ^@ http://purl.uniprot.org/uniprot/A0A9L0SX21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:KIAA1024 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I9N2 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9796:TMCC1 ^@ http://purl.uniprot.org/uniprot/F6U1U7 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9796:RPS16 ^@ http://purl.uniprot.org/uniprot/A0A9L0RTX8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/9796:COMTD1 ^@ http://purl.uniprot.org/uniprot/F6SJB9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9796:MSX2 ^@ http://purl.uniprot.org/uniprot/F7AIQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PKNOX2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S3M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9796:GJA1 ^@ http://purl.uniprot.org/uniprot/F6SK35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Endoplasmic reticulum|||Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/F6TXS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9796:RNASE11 ^@ http://purl.uniprot.org/uniprot/F6TU58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9796:FUT7 ^@ http://purl.uniprot.org/uniprot/F6YH91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/9796:METTL14 ^@ http://purl.uniprot.org/uniprot/F6XVY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MT-A70-like family.|||Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.|||Nucleus|||The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. http://togogenome.org/gene/9796:CLCN4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SH72 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:SENP1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNF3 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9796:LASP1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNY8 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9796:LOC100059285 ^@ http://purl.uniprot.org/uniprot/F6ZSB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9796:MRPL58 ^@ http://purl.uniprot.org/uniprot/A0A9L0TFR6 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9796:LOC100053069 ^@ http://purl.uniprot.org/uniprot/A0A7R8C3D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:RFX3 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNC8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:ACSL6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H6X6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9796:B4GALT4 ^@ http://purl.uniprot.org/uniprot/F7B8Z3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9796:GRK7 ^@ http://purl.uniprot.org/uniprot/F7AW96 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9796:GTF2A2 ^@ http://purl.uniprot.org/uniprot/K9K3Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/9796:SLC39A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SNA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:RCE1 ^@ http://purl.uniprot.org/uniprot/F6Q707 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:HCCS ^@ http://purl.uniprot.org/uniprot/A0A3Q2II97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:PRKAA1 ^@ http://purl.uniprot.org/uniprot/K9K2H2|||http://purl.uniprot.org/uniprot/Q2LGG0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9796:LOC100049837 ^@ http://purl.uniprot.org/uniprot/A0A9L0SZU5 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9796:ACTN3 ^@ http://purl.uniprot.org/uniprot/E7D103 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9796:MYF6 ^@ http://purl.uniprot.org/uniprot/F6ZFC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:UBC ^@ http://purl.uniprot.org/uniprot/Q8MKD1 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin family.|||Cytoplasm|||Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.|||For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.|||Interacts with SKP1-KMD2A and SKP1-KMD2B complexes.|||Mitochondrion outer membrane|||Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.|||Nucleus|||Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.|||Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. http://togogenome.org/gene/9796:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A9L0TGM2 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9796:C14H5orf63 ^@ http://purl.uniprot.org/uniprot/A0A9L0QYJ5 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/9796:CLNS1A ^@ http://purl.uniprot.org/uniprot/A0A5F5PKG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/9796:INPP4A ^@ http://purl.uniprot.org/uniprot/A0A3Q2HXC9 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9796:TIMM22 ^@ http://purl.uniprot.org/uniprot/F6Y1N3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:DCLRE1B ^@ http://purl.uniprot.org/uniprot/A0A9L0TNA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9796:RPF1 ^@ http://purl.uniprot.org/uniprot/F7CBY3|||http://purl.uniprot.org/uniprot/L7MS55 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9796:KRT73 ^@ http://purl.uniprot.org/uniprot/F7AGY4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:SLC17A9 ^@ http://purl.uniprot.org/uniprot/F6SRV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:MAK16 ^@ http://purl.uniprot.org/uniprot/A0A9L0TBR6 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9796:MOCS1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LQJ5|||http://purl.uniprot.org/uniprot/A0A9L0SBH6 ^@ Similarity ^@ In the C-terminal section; belongs to the MoaC family.|||In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. http://togogenome.org/gene/9796:PIGF ^@ http://purl.uniprot.org/uniprot/F6SYH3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:B4GALNT2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ICK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/9796:EQMHCC1 ^@ http://purl.uniprot.org/uniprot/Q30486 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:GGT5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RLZ1 ^@ Similarity ^@ Belongs to the gamma-glutamyltransferase family. http://togogenome.org/gene/9796:GPR179 ^@ http://purl.uniprot.org/uniprot/F6XV94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/K9K9G6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/9796:PRND ^@ http://purl.uniprot.org/uniprot/A2BDI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:IDNK ^@ http://purl.uniprot.org/uniprot/A0A9L0R7S3 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/9796:TRIM10 ^@ http://purl.uniprot.org/uniprot/F6XN17 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:IL5 ^@ http://purl.uniprot.org/uniprot/O02699 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked. Interacts with IL5RA. Interacts with CSF2RB.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).|||Secreted http://togogenome.org/gene/9796:ASPM ^@ http://purl.uniprot.org/uniprot/A0A9L0RS00 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:WNT7B ^@ http://purl.uniprot.org/uniprot/F6ZTB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9796:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A9L0TD79 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:NOX5 ^@ http://purl.uniprot.org/uniprot/F6ZC07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ANAPC15 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HN40|||http://purl.uniprot.org/uniprot/A0A9L0SLU5 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/9796:CSAD ^@ http://purl.uniprot.org/uniprot/A0A3Q2HWH1 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9796:GLIS3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4H4|||http://purl.uniprot.org/uniprot/F6UW52 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9796:PAPSS2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HJZ9|||http://purl.uniprot.org/uniprot/A0A5F5PPN6 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9796:CASR ^@ http://purl.uniprot.org/uniprot/F6SIB8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:HIP1 ^@ http://purl.uniprot.org/uniprot/F6UIN2 ^@ Similarity ^@ Belongs to the SLA2 family. http://togogenome.org/gene/9796:VNN2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q314 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/9796:LOC100058123 ^@ http://purl.uniprot.org/uniprot/F7CSF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:FAM133A ^@ http://purl.uniprot.org/uniprot/A0A3Q2KNL6 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9796:ARHGEF9 ^@ http://purl.uniprot.org/uniprot/A0A9L0TBN6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|||Cytoplasm|||Interacts with GPHN.|||Postsynaptic density http://togogenome.org/gene/9796:GORASP2 ^@ http://purl.uniprot.org/uniprot/F7BBI4 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9796:TMEM50B ^@ http://purl.uniprot.org/uniprot/K9K3L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9796:C31H6orf120 ^@ http://purl.uniprot.org/uniprot/A0A9L0SWB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.|||Secreted http://togogenome.org/gene/9796:GLIS2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RKH3 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9796:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/A0A9L0SEE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9796:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/A0A9L0R5Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9796:SPIN4 ^@ http://purl.uniprot.org/uniprot/F6Z3B6 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9796:LAMP5 ^@ http://purl.uniprot.org/uniprot/A0A5F5PWT5|||http://purl.uniprot.org/uniprot/F6X052 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9796:CA1 ^@ http://purl.uniprot.org/uniprot/F6ZBG0 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9796:LOC100060524 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I6K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:RAB27A ^@ http://purl.uniprot.org/uniprot/F6SEK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9796:FGB ^@ http://purl.uniprot.org/uniprot/F6PH38 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9796:PDCD4 ^@ http://purl.uniprot.org/uniprot/F6V2H7 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9796:LOXL3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H6U3|||http://purl.uniprot.org/uniprot/A0A9L0RLY7|||http://purl.uniprot.org/uniprot/A0A9L0TKN1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9796:LOC100067483 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KL72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9796:LOC102148936 ^@ http://purl.uniprot.org/uniprot/A0A9L0S0M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9796:SPACA3 ^@ http://purl.uniprot.org/uniprot/F7AAD0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9796:PPP2R5E ^@ http://purl.uniprot.org/uniprot/F7BAU9 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9796:ABL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S632|||http://purl.uniprot.org/uniprot/F7B6Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:RNASE1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T4B5|||http://purl.uniprot.org/uniprot/W0UTH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pancreatic ribonuclease family.|||Secreted http://togogenome.org/gene/9796:MED17 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LHF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9796:NDRG3 ^@ http://purl.uniprot.org/uniprot/F6XGK2 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9796:ACAD11 ^@ http://purl.uniprot.org/uniprot/A0A9L0T0P6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9796:TFE3 ^@ http://purl.uniprot.org/uniprot/F6T5E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9796:PARD6A ^@ http://purl.uniprot.org/uniprot/A0A3Q2H243 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/9796:RPL3 ^@ http://purl.uniprot.org/uniprot/F6UUX5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/9796:PIM1 ^@ http://purl.uniprot.org/uniprot/F6UWX4 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9796:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/F6SIS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9796:ARL4D ^@ http://purl.uniprot.org/uniprot/F7CXK4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9796:SEMA3A ^@ http://purl.uniprot.org/uniprot/F6R988 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:CTNNA3 ^@ http://purl.uniprot.org/uniprot/A0A9L0TIU3 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/9796:LOC100056625 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LJZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PAX7 ^@ http://purl.uniprot.org/uniprot/A0A5K1UQD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9796:FAM13A ^@ http://purl.uniprot.org/uniprot/A0A5F5PF39|||http://purl.uniprot.org/uniprot/A0A9L0T7N2|||http://purl.uniprot.org/uniprot/F7BVS7 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9796:DGKD ^@ http://purl.uniprot.org/uniprot/A0A5F5PZC9 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9796:CLTA ^@ http://purl.uniprot.org/uniprot/A0A5F5PF40|||http://purl.uniprot.org/uniprot/C0SW05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/9796:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/F6RLG3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9796:SNF8 ^@ http://purl.uniprot.org/uniprot/A0A9L0R0M7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/9796:IL4 ^@ http://purl.uniprot.org/uniprot/A7LBR9|||http://purl.uniprot.org/uniprot/P42202 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-4/IL-13 family.|||Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.|||Secreted http://togogenome.org/gene/9796:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RCC8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PDCL2 ^@ http://purl.uniprot.org/uniprot/F6SN00 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9796:SLC25A17 ^@ http://purl.uniprot.org/uniprot/A0A9L0TSI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:SNRPA1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SD24 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/9796:ERO1B ^@ http://purl.uniprot.org/uniprot/A0A3Q2GUN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9796:MSR1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HSD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:BSP2 ^@ http://purl.uniprot.org/uniprot/Q70GG5 ^@ Caution|||Similarity ^@ Belongs to the seminal plasma protein family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:MAB21L2 ^@ http://purl.uniprot.org/uniprot/F6RJ51 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9796:DMRTC2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IAT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/9796:TMSB10 ^@ http://purl.uniprot.org/uniprot/P63314 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).|||cytoskeleton http://togogenome.org/gene/9796:PRLR ^@ http://purl.uniprot.org/uniprot/F6Z164 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/9796:IZUMO3 ^@ http://purl.uniprot.org/uniprot/F7BAE4 ^@ Similarity ^@ Belongs to the Izumo family. http://togogenome.org/gene/9796:HSD3B2 ^@ http://purl.uniprot.org/uniprot/O46516 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.|||Belongs to the 3-beta-HSD family.|||Endoplasmic reticulum membrane|||Mitochondrion membrane http://togogenome.org/gene/9796:MRPS14 ^@ http://purl.uniprot.org/uniprot/F7C1X2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/9796:MEIS3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HFJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9796:PRDM14 ^@ http://purl.uniprot.org/uniprot/A0A9L0RU48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/F6Q8K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9796:LOC100056900 ^@ http://purl.uniprot.org/uniprot/F7DED7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NETO1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RSY3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:GSX2 ^@ http://purl.uniprot.org/uniprot/F7BJ43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:SLC16A7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L3Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9796:HNF4A ^@ http://purl.uniprot.org/uniprot/A0A5F5PJZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9796:SMPD5 ^@ http://purl.uniprot.org/uniprot/A0A9L0S7K9 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9796:HPD ^@ http://purl.uniprot.org/uniprot/F7BER4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit.|||Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9796:GLO1 ^@ http://purl.uniprot.org/uniprot/F7CHI7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/9796:HCAR1 ^@ http://purl.uniprot.org/uniprot/F6VLF2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:POT1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HK44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/9796:FGF21 ^@ http://purl.uniprot.org/uniprot/A0A7U3JWE1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KWQ8|||http://purl.uniprot.org/uniprot/A0A5F5PYB9|||http://purl.uniprot.org/uniprot/F6X7J3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9796:P2RX6 ^@ http://purl.uniprot.org/uniprot/A0A9L0T1X8|||http://purl.uniprot.org/uniprot/A0A9L0TVJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9796:TMEM88 ^@ http://purl.uniprot.org/uniprot/F6ZIM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/9796:CLCA1 ^@ http://purl.uniprot.org/uniprot/Q2TU62 ^@ Domain|||Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the CLCR family.|||Expressed in mucin-producing cells in the respiratory and intestinal tracts, cutaneous sweat glands, and renal mucous glands (at protein level). Strong overexpression in the airways of horses with recurrent airway obstruction (at protein level).|||Glycosylated.|||May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (By similarity).|||Strongly up-regulated in bronchioles with recurrent airway obstruction (RAO).|||The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.|||The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.|||extracellular space http://togogenome.org/gene/9796:TCN2 ^@ http://purl.uniprot.org/uniprot/F6U5V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9796:HCRT ^@ http://purl.uniprot.org/uniprot/F6TU74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the orexin family.|||Endoplasmic reticulum|||Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.|||Rough endoplasmic reticulum|||Synapse|||Vesicle http://togogenome.org/gene/9796:MCEE ^@ http://purl.uniprot.org/uniprot/A0A9L0R373 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9796:SLC2A12 ^@ http://purl.uniprot.org/uniprot/A0A9L0TIV7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. http://togogenome.org/gene/9796:LOC100060186 ^@ http://purl.uniprot.org/uniprot/A0A1W1GCG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9796:B4GALT7 ^@ http://purl.uniprot.org/uniprot/A0A9L0TKP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9796:TSSC4 ^@ http://purl.uniprot.org/uniprot/F7BWG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:RPL35 ^@ http://purl.uniprot.org/uniprot/A0A5F5PZ86 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9796:HS2ST1 ^@ http://purl.uniprot.org/uniprot/F6UYS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:FAHD1 ^@ http://purl.uniprot.org/uniprot/F7A6M5 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9796:KRTAP24-1 ^@ http://purl.uniprot.org/uniprot/F6UYV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9796:CA12 ^@ http://purl.uniprot.org/uniprot/A5YBM0 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9796:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9796:CLCN5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RSC8|||http://purl.uniprot.org/uniprot/F7BAS5 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:APOA4 ^@ http://purl.uniprot.org/uniprot/A0A5F5PEE6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein A1/A4/E family.|||Extracellular vesicle|||Homotetramer. May interact with ABCA1; functionally associated with ABCA1 in the biogenesis of HDLs. May interact with APP/A4 amyloid-beta peptide; the interaction is extremely stable in vitro but its physiological significance is unclear. May interact with MAPT. May interact with MAP2. In the cerebrospinal fluid, interacts with secreted SORL1. Interacts with PMEL; this allows the loading of PMEL luminal fragment on ILVs to induce fibril nucleation.|||Vesicle|||extracellular matrix|||multivesicular body http://togogenome.org/gene/9796:ODF2L ^@ http://purl.uniprot.org/uniprot/A0A9L0TL60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/9796:ABCC2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I0Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100068803 ^@ http://purl.uniprot.org/uniprot/A0A9L0TG50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:OAS3 ^@ http://purl.uniprot.org/uniprot/Q5J0M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9796:KCNA6 ^@ http://purl.uniprot.org/uniprot/F7DZR3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ZNF287 ^@ http://purl.uniprot.org/uniprot/F6Z3M1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:OASL ^@ http://purl.uniprot.org/uniprot/Q5MY91 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/9796:BRINP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SQ00 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9796:SQLE ^@ http://purl.uniprot.org/uniprot/F6ZRA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9796:CDADC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TG27 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/9796:FABP5 ^@ http://purl.uniprot.org/uniprot/A0A5F5PY53 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9796:IL7 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q112|||http://purl.uniprot.org/uniprot/A0A9L0T254 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-7/IL-9 family.|||Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.|||Interacts with IL7R and CSF2RG.|||Secreted http://togogenome.org/gene/9796:ALAS2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PQU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:TATDN1 ^@ http://purl.uniprot.org/uniprot/L7MRM1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9796:FASLG ^@ http://purl.uniprot.org/uniprot/F6YI29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tumor necrosis factor family.|||Cell membrane|||Cytoplasmic form induces gene transcription inhibition.|||Cytoplasmic vesicle lumen|||Lysosome lumen|||Nucleus|||Secreted http://togogenome.org/gene/9796:FGF2 ^@ http://purl.uniprot.org/uniprot/E0AEV7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:GPAT3 ^@ http://purl.uniprot.org/uniprot/F6YT89 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9796:PDE4B ^@ http://purl.uniprot.org/uniprot/A0A5F5PMF0|||http://purl.uniprot.org/uniprot/A0A9L0SM57 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9796:CCNH ^@ http://purl.uniprot.org/uniprot/A0A9L0RUG3 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family. Cyclin C subfamily.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/9796:FAM19A2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I5E4 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9796:EBF1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RKM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9796:IL6ST ^@ http://purl.uniprot.org/uniprot/A0A3Q2KQU3|||http://purl.uniprot.org/uniprot/F7CFP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9796:AASDH ^@ http://purl.uniprot.org/uniprot/A0A3Q2I8P3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9796:ABLIM3 ^@ http://purl.uniprot.org/uniprot/A0A9L0R295|||http://purl.uniprot.org/uniprot/F6YME5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:VEGFA ^@ http://purl.uniprot.org/uniprot/Q9GKR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDGF/VEGF growth factor family.|||Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).|||Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (By similarity). Interacts with BSG (By similarity).|||Secreted http://togogenome.org/gene/9796:NMD3 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q146 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:HACL1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PX33 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9796:HDHD3 ^@ http://purl.uniprot.org/uniprot/A0A9L0R8Y1|||http://purl.uniprot.org/uniprot/A0A9L0RWL5 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9796:TRPV1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4H5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC106782672 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HQ09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9796:BAMBI ^@ http://purl.uniprot.org/uniprot/F6X7H5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/9796:ATP6V1E2 ^@ http://purl.uniprot.org/uniprot/F6ZMJ5 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9796:LYG1 ^@ http://purl.uniprot.org/uniprot/F6TJC3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9796:USB1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PYX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/9796:CHDH ^@ http://purl.uniprot.org/uniprot/A0A9L0TMQ5 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/9796:C13H16orf71 ^@ http://purl.uniprot.org/uniprot/F7D342 ^@ Function|||Subcellular Location Annotation ^@ Dynein axonemal particle|||In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits. http://togogenome.org/gene/9796:DCST1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KLW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100062794 ^@ http://purl.uniprot.org/uniprot/F6WEX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SNRNP200 ^@ http://purl.uniprot.org/uniprot/F7E0H9 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/9796:LIPM ^@ http://purl.uniprot.org/uniprot/A0A5F5PZ19 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9796:LOC100068309 ^@ http://purl.uniprot.org/uniprot/F6UPC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100057021 ^@ http://purl.uniprot.org/uniprot/F7CSG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TIMM10B ^@ http://purl.uniprot.org/uniprot/A0A9R1SPL7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9796:SPOP ^@ http://purl.uniprot.org/uniprot/F7A1J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/9796:MED6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RDP5|||http://purl.uniprot.org/uniprot/F6XBG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9796:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S4C9 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9796:CHD8 ^@ http://purl.uniprot.org/uniprot/F6XQ51 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.|||DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.|||Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Sumoylated. http://togogenome.org/gene/9796:TMX2 ^@ http://purl.uniprot.org/uniprot/F7DNF2 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9796:LOC100051065 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LAR7 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/9796:SLC27A5 ^@ http://purl.uniprot.org/uniprot/A0A5F5PXH2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9796:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KN79|||http://purl.uniprot.org/uniprot/F6VJI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9796:CRIPT ^@ http://purl.uniprot.org/uniprot/K9K3R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/9796:CLDN3 ^@ http://purl.uniprot.org/uniprot/A0A9L0S6H1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:RDH12 ^@ http://purl.uniprot.org/uniprot/A0A9L0QZK9|||http://purl.uniprot.org/uniprot/F7BZV2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:LOC100057054 ^@ http://purl.uniprot.org/uniprot/A0A5F5PIH4 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9796:BCAR1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LGL0|||http://purl.uniprot.org/uniprot/F7C5Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/9796:ADORA1 ^@ http://purl.uniprot.org/uniprot/F6RAN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9796:LOC100146186 ^@ http://purl.uniprot.org/uniprot/A0A5F5PUA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:EIF2B1 ^@ http://purl.uniprot.org/uniprot/F6R6B2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/9796:LOC100063245 ^@ http://purl.uniprot.org/uniprot/F6WLG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100060140 ^@ http://purl.uniprot.org/uniprot/A0A5F5PZ71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm http://togogenome.org/gene/9796:LPGAT1 ^@ http://purl.uniprot.org/uniprot/F7BJG2 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9796:PARP15 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HSB8|||http://purl.uniprot.org/uniprot/F6S617 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9796:GNLY ^@ http://purl.uniprot.org/uniprot/Q8HZQ3 ^@ Function|||Subcellular Location Annotation ^@ May be an effector molecule of cytotoxic activity. Has antimicrobial activity (By similarity).|||Secreted http://togogenome.org/gene/9796:LOC100071911 ^@ http://purl.uniprot.org/uniprot/A0A9L0S8U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LIX1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S8T6 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9796:OGT ^@ http://purl.uniprot.org/uniprot/F6Z4I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/9796:MANEA ^@ http://purl.uniprot.org/uniprot/F6RHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:MTRF1L ^@ http://purl.uniprot.org/uniprot/A0A9L0T7J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/9796:FAM3B ^@ http://purl.uniprot.org/uniprot/A0A9L0RFC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9796:RRP7A ^@ http://purl.uniprot.org/uniprot/A0A9L0T7W4 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/9796:HPS6 ^@ http://purl.uniprot.org/uniprot/F6SBX5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||Microsome membrane http://togogenome.org/gene/9796:CREB1 ^@ http://purl.uniprot.org/uniprot/I3WD93 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:IL17F ^@ http://purl.uniprot.org/uniprot/A0A3Q2LLK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9796:LAMC2 ^@ http://purl.uniprot.org/uniprot/Q8HZI9 ^@ Domain|||Function|||Miscellaneous|||PTM|||Subcellular Location Annotation|||Subunit ^@ Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.|||Binds heparin.|||Domain IV is globular.|||Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-2 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein).|||O-glycosylated; contains chondroitin sulfate (CS).|||The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.|||basement membrane http://togogenome.org/gene/9796:TMEM126B ^@ http://purl.uniprot.org/uniprot/A0A9L0TBA7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100053545 ^@ http://purl.uniprot.org/uniprot/A0A9L0THF4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:PATZ1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L0R5|||http://purl.uniprot.org/uniprot/A0A3Q2LPV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TNFSF14 ^@ http://purl.uniprot.org/uniprot/F6SZH4 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9796:ACSL5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KPY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9796:LOC106780858 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H2V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:RPL15 ^@ http://purl.uniprot.org/uniprot/F6RMA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Cytoplasm http://togogenome.org/gene/9796:IFT20 ^@ http://purl.uniprot.org/uniprot/A0A9L0T503 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9796:CD244 ^@ http://purl.uniprot.org/uniprot/F7B7X4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:PDP2 ^@ http://purl.uniprot.org/uniprot/F7A4F3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9796:CLDN11 ^@ http://purl.uniprot.org/uniprot/A0A5F5PE66 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:SERPINB1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R8G2|||http://purl.uniprot.org/uniprot/P05619 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Belongs to the serpin family. Ov-serpin subfamily.|||Cytolytic granule|||Cytoplasm|||Early endosome|||Monomer. Interacts (via C-terminus) with CASP1; CASP4 (via CARD domain) and CASP5; these interactions regulate the activity of inflammatory caspases. Interacts with PRTN3. Interacts with GZMH (By similarity). Interacts with TMSB4 (PubMed:1551869).|||Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function.|||Secreted|||The N-terminus is blocked. http://togogenome.org/gene/9796:LOC100053477 ^@ http://purl.uniprot.org/uniprot/A0A9L0T5B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:AKR1A1 ^@ http://purl.uniprot.org/uniprot/K9K2L1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9796:TBCE ^@ http://purl.uniprot.org/uniprot/K9K4M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Cytoplasm http://togogenome.org/gene/9796:G6PC2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H3S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9796:KEF40_p11 ^@ http://purl.uniprot.org/uniprot/A5JYA3|||http://purl.uniprot.org/uniprot/P48659 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heme-copper respiratory oxidase family.|||Binds 2 heme A groups non-covalently per subunit.|||Binds a copper B center.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:OS9 ^@ http://purl.uniprot.org/uniprot/D0V860 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9796:EMP3 ^@ http://purl.uniprot.org/uniprot/A0A9L0R5R9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/9796:CCNT2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I916 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9796:ELP2 ^@ http://purl.uniprot.org/uniprot/F6Q5J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:ZNF830 ^@ http://purl.uniprot.org/uniprot/F6Y5B4 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus speckle http://togogenome.org/gene/9796:ALPL ^@ http://purl.uniprot.org/uniprot/A0A9L0S3W7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9796:DPCD ^@ http://purl.uniprot.org/uniprot/A0A3Q2GU71 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/9796:BCAP31 ^@ http://purl.uniprot.org/uniprot/F6V5V5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/9796:NDUFA10 ^@ http://purl.uniprot.org/uniprot/A0A9L0RXI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix http://togogenome.org/gene/9796:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HA46 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:TBX5 ^@ http://purl.uniprot.org/uniprot/F6Z6Q0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9796:NEUROD1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LT89 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100051428 ^@ http://purl.uniprot.org/uniprot/F6W9S2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CCK ^@ http://purl.uniprot.org/uniprot/F7BAG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/9796:EXOG ^@ http://purl.uniprot.org/uniprot/A0A5F5PS14 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9796:S100A7 ^@ http://purl.uniprot.org/uniprot/Q14ST5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the S-100 family.|||Cytoplasm|||Interacts with RANBP9.|||Secreted http://togogenome.org/gene/9796:GAST ^@ http://purl.uniprot.org/uniprot/F6SYU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.|||Secreted http://togogenome.org/gene/9796:SMAD9 ^@ http://purl.uniprot.org/uniprot/A0A9L0TPP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:CAPN6 ^@ http://purl.uniprot.org/uniprot/A0A5F5PED9 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC100068137 ^@ http://purl.uniprot.org/uniprot/F6UQF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DUSP10 ^@ http://purl.uniprot.org/uniprot/F6S237 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9796:SPO11 ^@ http://purl.uniprot.org/uniprot/F6PUB2 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/9796:TRIAP1 ^@ http://purl.uniprot.org/uniprot/F6SCK3 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9796:SLC44A2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PSJ0|||http://purl.uniprot.org/uniprot/A0A9L0SSU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9796:MAP2K1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TN27 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:SLC16A4 ^@ http://purl.uniprot.org/uniprot/A0A9L0RN39|||http://purl.uniprot.org/uniprot/A0A9L0TDB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:BMP10 ^@ http://purl.uniprot.org/uniprot/F7DLP6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9796:FRZB ^@ http://purl.uniprot.org/uniprot/F6WNV3 ^@ Caution|||Function|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/9796:TIMP3 ^@ http://purl.uniprot.org/uniprot/Q9TUL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.|||Interacts with EFEMP1.|||extracellular matrix http://togogenome.org/gene/9796:YIPF5 ^@ http://purl.uniprot.org/uniprot/F6PLB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/9796:ANXA2 ^@ http://purl.uniprot.org/uniprot/B2B9I8|||http://purl.uniprot.org/uniprot/K9K271 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.|||Membrane|||basement membrane http://togogenome.org/gene/9796:RAD1 ^@ http://purl.uniprot.org/uniprot/F6YZW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/9796:TYW3 ^@ http://purl.uniprot.org/uniprot/F6WF67 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/9796:BORCS7 ^@ http://purl.uniprot.org/uniprot/A0A5K1UV87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS7 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9796:SLC10A7 ^@ http://purl.uniprot.org/uniprot/A0A5F5PTP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Cell membrane|||Does not show transport activity towards bile acids or steroid sulfates.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9796:CHAF1B ^@ http://purl.uniprot.org/uniprot/F6U7T6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TMED1 ^@ http://purl.uniprot.org/uniprot/F6YEA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9796:KIF2C ^@ http://purl.uniprot.org/uniprot/A0A9L0RUZ3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9796:LOC100066846 ^@ http://purl.uniprot.org/uniprot/F6TC71 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:GPN2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S1M9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/9796:TGM3 ^@ http://purl.uniprot.org/uniprot/F6YMM5 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9796:CSN1S1 ^@ http://purl.uniprot.org/uniprot/Q8SPR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-casein family.|||Important role in the capacity of milk to transport calcium phosphate.|||Secreted http://togogenome.org/gene/9796:LOC106781327 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ID35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9796:IRF8 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L2I3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:DDX59 ^@ http://purl.uniprot.org/uniprot/A0A9L0S6L3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/9796:DSG4 ^@ http://purl.uniprot.org/uniprot/F7CMD3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/9796:LOC100052971 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HLF6|||http://purl.uniprot.org/uniprot/A0A7R8GV06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:LOC100055538 ^@ http://purl.uniprot.org/uniprot/F6WQZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ARSF ^@ http://purl.uniprot.org/uniprot/A0A5F5Q434 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9796:LOC100052081 ^@ http://purl.uniprot.org/uniprot/F6Q015 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9796:TIGD4 ^@ http://purl.uniprot.org/uniprot/F7AYM3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:DDC ^@ http://purl.uniprot.org/uniprot/A0A9L0TM35 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9796:TTC26 ^@ http://purl.uniprot.org/uniprot/F7CHH6 ^@ Similarity ^@ Belongs to the IFT56 family. http://togogenome.org/gene/9796:ESD ^@ http://purl.uniprot.org/uniprot/A0A9L0T766 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9796:CLDN34 ^@ http://purl.uniprot.org/uniprot/F6Q4B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9796:AQP10 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HMG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LOC100060726 ^@ http://purl.uniprot.org/uniprot/F6PKF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CDC123 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HUW9|||http://purl.uniprot.org/uniprot/K9K223 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/9796:MED7 ^@ http://purl.uniprot.org/uniprot/K9K3K8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9796:LOC100070635 ^@ http://purl.uniprot.org/uniprot/F6ZFX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:RAG2 ^@ http://purl.uniprot.org/uniprot/F6WS62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/9796:ACTB ^@ http://purl.uniprot.org/uniprot/P60708 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).|||Belongs to the actin family.|||ISGylated.|||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.|||Methylated at His-73 by SETD3 (By similarity). Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity).|||Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.|||N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.|||N-terminal cleavage of acetylated methionine of immature cytoplasmic actin by ACTMAP.|||Nucleus|||Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.|||Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM (By similarity). Interacts with TBC1D21. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes. Interacts with FAM107A (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The filament contains 8 copies of ACTR1A and 1 ACTB (By similarity).|||cytoskeleton http://togogenome.org/gene/9796:CSTF1 ^@ http://purl.uniprot.org/uniprot/F6S5J7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:GMFB ^@ http://purl.uniprot.org/uniprot/A0A9R1SQM9 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9796:FAM20B ^@ http://purl.uniprot.org/uniprot/A0A3Q2LMD2 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/9796:ENKD1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RML6 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9796:OXSR1 ^@ http://purl.uniprot.org/uniprot/F7CMY7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9796:TRPC4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HI07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:IL2 ^@ http://purl.uniprot.org/uniprot/B1AB81|||http://purl.uniprot.org/uniprot/P37997 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/9796:CLDN4 ^@ http://purl.uniprot.org/uniprot/F6Z8Q3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/F7B020 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:RPL29 ^@ http://purl.uniprot.org/uniprot/F7DCZ5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9796:B3GNT2 ^@ http://purl.uniprot.org/uniprot/F6XBJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:MRPS11 ^@ http://purl.uniprot.org/uniprot/F7BVG1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/9796:HSD17B4 ^@ http://purl.uniprot.org/uniprot/Q6RFZ6 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9796:TRAPPC9 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q0P9|||http://purl.uniprot.org/uniprot/F6WZ99 ^@ Similarity ^@ Belongs to the NIBP family. http://togogenome.org/gene/9796:PNRC2 ^@ http://purl.uniprot.org/uniprot/F6QQ93 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:POR ^@ http://purl.uniprot.org/uniprot/B1PL89 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. http://togogenome.org/gene/9796:COPS4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I1G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/9796:MAST4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H9G7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9796:OPHN1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PP84 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Postsynapse|||Presynapse|||dendrite http://togogenome.org/gene/9796:ATP2B4 ^@ http://purl.uniprot.org/uniprot/A0A9L0R4P2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:BCL2L1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SSI5|||http://purl.uniprot.org/uniprot/F6WQI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9796:LOC100054771 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I6J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100068355 ^@ http://purl.uniprot.org/uniprot/A0A9L0S1T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DNTT ^@ http://purl.uniprot.org/uniprot/F6V4S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/9796:CLDN2 ^@ http://purl.uniprot.org/uniprot/F6YS83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:F13B ^@ http://purl.uniprot.org/uniprot/F7C7J6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:MINDY4 ^@ http://purl.uniprot.org/uniprot/A0A9L0R1M6 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/9796:LOC100071946 ^@ http://purl.uniprot.org/uniprot/F6U6Y2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:IL17A ^@ http://purl.uniprot.org/uniprot/B3VH88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9796:AURKC ^@ http://purl.uniprot.org/uniprot/F6XUG2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/9796:LOC100065392 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HNX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/9796:SEPT11 ^@ http://purl.uniprot.org/uniprot/A0A9L0S7A6|||http://purl.uniprot.org/uniprot/A0A9L0TBE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9796:CYP1B1 ^@ http://purl.uniprot.org/uniprot/F7E336 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9796:CTU2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TA55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTU2/NCS2 family.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/9796:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A9L0S5W8|||http://purl.uniprot.org/uniprot/F6VVL8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9796:IMP3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GXM6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9796:LOC100056513 ^@ http://purl.uniprot.org/uniprot/F6TX98 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9796:SGCZ ^@ http://purl.uniprot.org/uniprot/A0A9L0SBF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9796:PPP2CB ^@ http://purl.uniprot.org/uniprot/A0A9L0S645 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9796:NDST3 ^@ http://purl.uniprot.org/uniprot/F6U2J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9796:LTB ^@ http://purl.uniprot.org/uniprot/A0A9L0RJ77 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9796:MRPL32 ^@ http://purl.uniprot.org/uniprot/F6Y3H3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/9796:ALLC ^@ http://purl.uniprot.org/uniprot/F7AJG7 ^@ Function|||Similarity ^@ Belongs to the allantoicase family.|||The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. http://togogenome.org/gene/9796:SCN4A ^@ http://purl.uniprot.org/uniprot/Q28371 ^@ Activity Regulation|||Disease Annotation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.|||Cell membrane|||Channel activity is regulated by the ancillary beta subunit SCN1B. SCN1B strongly enhances the presence of the pore-forming alpha subunit at the cell surface (By similarity). Interaction with SCN1B is required for rapid channel inactivation and rapid recovery after inactivation, and prevents decrease of channel activity in response to repetitive, high-frequency depolarizations. The channel is inhibited by tetrodotoxin (By similarity).|||Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits. Interacts with SCN1B (By similarity). Heterooligomer with SCN2B or SCN4B; disulfide-linked (By similarity). Interacts with the PDZ domain of the syntrophins SNTA1, SNTB1 and SNTB2 (By similarity). Interacts with the conotoxin GVIIJ (By similarity).|||Defects in SCN4A are the cause of periodic paralysis hyperkalemic (HYPP). HYPP is an autosomal dominant channelopathy characterized by episodic flaccid generalized muscle weakness associated with high levels of serum potassium. HYPP is frequently found in Quarter Horses, the most popular equine breed in the United States.|||Phosphorylation at Ser-1325 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.|||Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states (By similarity). Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels (PubMed:1338908).|||The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position. http://togogenome.org/gene/9796:GSPT1 ^@ http://purl.uniprot.org/uniprot/F6YDK2 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/9796:LOC106782043 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KNA3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:KCNJ15 ^@ http://purl.uniprot.org/uniprot/F6T921 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9796:SSBP1 ^@ http://purl.uniprot.org/uniprot/F6RJN1 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9796:POP5 ^@ http://purl.uniprot.org/uniprot/A0A9L0SM70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9796:ABCD3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I8N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9796:SPOCK1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LCK9|||http://purl.uniprot.org/uniprot/A0A9L0SC23 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:BMP1 ^@ http://purl.uniprot.org/uniprot/F6YTB8 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ATP5F1A ^@ http://purl.uniprot.org/uniprot/F6XUJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9796:HTR6 ^@ http://purl.uniprot.org/uniprot/F6S7S0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:TM4SF18 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HL31|||http://purl.uniprot.org/uniprot/F7A0Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9796:VPS8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SDI3 ^@ Similarity ^@ Belongs to the VPS8 family. http://togogenome.org/gene/9796:KCNMB1 ^@ http://purl.uniprot.org/uniprot/F6WGD4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9796:CCR5 ^@ http://purl.uniprot.org/uniprot/A4ZZ54 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:SLC35B4 ^@ http://purl.uniprot.org/uniprot/F6RUW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9796:DLK2 ^@ http://purl.uniprot.org/uniprot/F6U2R6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:SATB2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RDT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9796:LOC100146503 ^@ http://purl.uniprot.org/uniprot/F7BSE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CDCA5 ^@ http://purl.uniprot.org/uniprot/A0A9L0TT78 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9796:LOC100051562 ^@ http://purl.uniprot.org/uniprot/A0A9L0RPN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9796:IL20 ^@ http://purl.uniprot.org/uniprot/A0A7R8C3Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9796:INHBA ^@ http://purl.uniprot.org/uniprot/P55102 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3 (By similarity).|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9796:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A3Q2HWB3|||http://purl.uniprot.org/uniprot/A0A3Q2LGK1|||http://purl.uniprot.org/uniprot/A0A9L0R885 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9796:LOC100068669 ^@ http://purl.uniprot.org/uniprot/F6VSH0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100058025 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HWI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DHFR ^@ http://purl.uniprot.org/uniprot/A0A9L0SH18 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/9796:ITGA1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HMM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9796:LOC100070352 ^@ http://purl.uniprot.org/uniprot/A0A9L0S3M2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/9796:ABCB11 ^@ http://purl.uniprot.org/uniprot/F6VD15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100070651 ^@ http://purl.uniprot.org/uniprot/F7B6T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CALB2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PXI5 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/9796:LOC102147679 ^@ http://purl.uniprot.org/uniprot/A0A9L0RUZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:APOC4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SV57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C4 family.|||May participate in lipoprotein metabolism.|||Secreted http://togogenome.org/gene/9796:PDC ^@ http://purl.uniprot.org/uniprot/Q9XS39 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosducin family.|||Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with CRX (By similarity).|||Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.|||May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity).|||Nucleus|||Photoreceptor inner segment|||cytosol|||photoreceptor outer segment http://togogenome.org/gene/9796:TFB1M ^@ http://purl.uniprot.org/uniprot/F6W4I0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. http://togogenome.org/gene/9796:LOC100063722 ^@ http://purl.uniprot.org/uniprot/F7D4Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9796:LOC100067992 ^@ http://purl.uniprot.org/uniprot/F6V5Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MMP9 ^@ http://purl.uniprot.org/uniprot/A8HDR2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9796:C22H20orf27 ^@ http://purl.uniprot.org/uniprot/A0A5F5PKP4 ^@ Similarity ^@ Belongs to the ADISSP family. http://togogenome.org/gene/9796:CDS2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RAD2|||http://purl.uniprot.org/uniprot/A0A9L0SLJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/9796:GPC3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L6D3|||http://purl.uniprot.org/uniprot/F7B944 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9796:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A9L0TLG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9796:NEFL ^@ http://purl.uniprot.org/uniprot/F6W6H2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:CCL8 ^@ http://purl.uniprot.org/uniprot/A0A9L0SWW3|||http://purl.uniprot.org/uniprot/Q8MKC8|||http://purl.uniprot.org/uniprot/Q9TTQ2 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9796:TMLHE ^@ http://purl.uniprot.org/uniprot/A0A9L0SQK4 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/9796:GREM1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S4T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9796:PTEN ^@ http://purl.uniprot.org/uniprot/A0A024QYT2 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/9796:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/K9K2G2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9796:ICOS ^@ http://purl.uniprot.org/uniprot/A0A3Q2HRX2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9796:CLP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HKP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/9796:STAT1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PXT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:PKIB ^@ http://purl.uniprot.org/uniprot/A0A3Q2HFF9|||http://purl.uniprot.org/uniprot/A0A5F5PR65 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9796:SYNGR3 ^@ http://purl.uniprot.org/uniprot/A0A9L0R234 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9796:LOC100065063 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GYU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9796:ADD1 ^@ http://purl.uniprot.org/uniprot/F7AM06 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9796:SPTSSB ^@ http://purl.uniprot.org/uniprot/F6S733 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:LPIN1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SSB4 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9796:MINPP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I7G4 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. MINPP1 subfamily. http://togogenome.org/gene/9796:TSPYL1 ^@ http://purl.uniprot.org/uniprot/F6WJS9 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9796:DCSTAMP ^@ http://purl.uniprot.org/uniprot/F7AUM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:NPR2 ^@ http://purl.uniprot.org/uniprot/F6T668 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9796:MAPK6 ^@ http://purl.uniprot.org/uniprot/A0A9L0R7K5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9796:TAF2 ^@ http://purl.uniprot.org/uniprot/F6WIT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/9796:ABCA10 ^@ http://purl.uniprot.org/uniprot/A0A9L0RNL0|||http://purl.uniprot.org/uniprot/A0A9L0S1S8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:PDIK1L ^@ http://purl.uniprot.org/uniprot/A0A9L0SGR8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:GIF ^@ http://purl.uniprot.org/uniprot/F6TLY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9796:IFN-ALPHA2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KSE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:GSTK1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TGV9 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/9796:LOC100065752 ^@ http://purl.uniprot.org/uniprot/F6XY78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9796:NAB2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HXP8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9796:UROS ^@ http://purl.uniprot.org/uniprot/A0A9L0T0X5 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/9796:CDC42BPA ^@ http://purl.uniprot.org/uniprot/A0A3Q2KRM9|||http://purl.uniprot.org/uniprot/A0A3Q2LBI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||Cytoplasm|||lamellipodium http://togogenome.org/gene/9796:RPL10L ^@ http://purl.uniprot.org/uniprot/A0A5F5PKM2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9796:B9D2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TPX4 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9796:ANXA7 ^@ http://purl.uniprot.org/uniprot/A0A5F5PP70 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9796:PNLIP ^@ http://purl.uniprot.org/uniprot/F7BR43|||http://purl.uniprot.org/uniprot/P29183 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Forms a 1:1 stoichiometric complex with (pro)colipase/CLPS.|||Inhibited by bile salts, is reactivated by (pro)colipase/CLPS.|||Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.|||Secreted http://togogenome.org/gene/9796:CHRNA1 ^@ http://purl.uniprot.org/uniprot/F7E1H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:PSMB8 ^@ http://purl.uniprot.org/uniprot/F6Z8V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:CAP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SP59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:GDPD2 ^@ http://purl.uniprot.org/uniprot/F6UF92 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9796:WISP3 ^@ http://purl.uniprot.org/uniprot/F7BDT2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:CDK1 ^@ http://purl.uniprot.org/uniprot/K9K3T8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:PRM2 ^@ http://purl.uniprot.org/uniprot/F7VJL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protamine P2 family.|||Interacts with TDRP.|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. http://togogenome.org/gene/9796:RPA3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SA79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/9796:C8H18orf25 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HD18|||http://purl.uniprot.org/uniprot/A0A3Q2IF56|||http://purl.uniprot.org/uniprot/A0A9L0SEL4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:ITIH1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S1S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9796:ORMDL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TFH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9796:LOC100071438 ^@ http://purl.uniprot.org/uniprot/F6Y447 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TIPIN ^@ http://purl.uniprot.org/uniprot/L7MRU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/9796:TP53 ^@ http://purl.uniprot.org/uniprot/E9NME8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Mitochondrion matrix|||Nucleus|||PML body|||centrosome http://togogenome.org/gene/9796:TMEM255A ^@ http://purl.uniprot.org/uniprot/A0A3Q2H8N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/9796:APC ^@ http://purl.uniprot.org/uniprot/A0A3Q2H5U9|||http://purl.uniprot.org/uniprot/A0A3Q2H7L9|||http://purl.uniprot.org/uniprot/A0A9L0RTS6 ^@ Similarity ^@ Belongs to the adenomatous polyposis coli (APC) family. http://togogenome.org/gene/9796:RPS6KA1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GTT1|||http://purl.uniprot.org/uniprot/A0A3Q2GVU3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9796:PCLAF ^@ http://purl.uniprot.org/uniprot/A0A9R1SEA8 ^@ Subcellular Location Annotation ^@ Nucleus|||perinuclear region http://togogenome.org/gene/9796:ERMN ^@ http://purl.uniprot.org/uniprot/F6Y4D3 ^@ Function|||Subunit ^@ Binds actin.|||Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS. http://togogenome.org/gene/9796:LOC102148457 ^@ http://purl.uniprot.org/uniprot/A0A9L0S5I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/9796:SNCA ^@ http://purl.uniprot.org/uniprot/F6U044 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synuclein family.|||Membrane|||Nucleus|||Secreted|||Synapse|||axon http://togogenome.org/gene/9796:BRS3 ^@ http://purl.uniprot.org/uniprot/F6TFU8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/9796:NLGN1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SLN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PGGT1B ^@ http://purl.uniprot.org/uniprot/A0A9L0SPP4 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/9796:DLX5 ^@ http://purl.uniprot.org/uniprot/F7DY45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9796:FABP2 ^@ http://purl.uniprot.org/uniprot/Q673L7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9796:GLRA1 ^@ http://purl.uniprot.org/uniprot/F6UQM3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9796:LY49F ^@ http://purl.uniprot.org/uniprot/Q75XR1|||http://purl.uniprot.org/uniprot/Q75XR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CDH3 ^@ http://purl.uniprot.org/uniprot/F6Z621 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:CHST3 ^@ http://purl.uniprot.org/uniprot/A0A9L0S0Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9796:LOC100058842 ^@ http://purl.uniprot.org/uniprot/F6V0T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CXCR2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SRZ7|||http://purl.uniprot.org/uniprot/F7A345 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:MYOD1 ^@ http://purl.uniprot.org/uniprot/F6W511 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9796:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SXZ8|||http://purl.uniprot.org/uniprot/F6SHV6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:DNASE2B ^@ http://purl.uniprot.org/uniprot/F7BX32 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/9796:COX15 ^@ http://purl.uniprot.org/uniprot/A0A9L0TG46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/9796:TIGD6 ^@ http://purl.uniprot.org/uniprot/Q4W445 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:CCDC65 ^@ http://purl.uniprot.org/uniprot/F6UPA4 ^@ Subcellular Location Annotation ^@ flagellum axoneme http://togogenome.org/gene/9796:MMP27 ^@ http://purl.uniprot.org/uniprot/F6UI50 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9796:PEX19 ^@ http://purl.uniprot.org/uniprot/A0A5F5PWG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Membrane|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/9796:ANK1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0W2|||http://purl.uniprot.org/uniprot/A0A3Q2H2N6 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9796:PLN ^@ http://purl.uniprot.org/uniprot/A0A3Q2HEF2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9796:KIF11 ^@ http://purl.uniprot.org/uniprot/A0A9L0S0T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.|||spindle pole http://togogenome.org/gene/9796:NANOG ^@ http://purl.uniprot.org/uniprot/A0A9L0SFT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:QKI ^@ http://purl.uniprot.org/uniprot/Q5W9D6 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the quaking family.|||Cytoplasm|||Homodimer; does not require RNA to homodimerize (By similarity). Able to heterodimerize with BICC1 (By similarity).|||Methylated by PRMT1.|||Nucleus|||RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Plays a central role in myelinization via 3 distinct mechanisms (By similarity). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation. Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA. Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation. Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (By similarity). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts. Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1. Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (By similarity). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity).|||The KH domain and the Qua2 region are involved in RNA binding.|||Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity).|||Ubiquitinated by RNF6 in macrophages, leading to its degradation. http://togogenome.org/gene/9796:AIMP2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SWB1 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/9796:ALB ^@ http://purl.uniprot.org/uniprot/P35747 ^@ Allergen|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the ALB/AFP/VDB family.|||Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).|||Can cause allergic reactions in humans. Binds to IgE.|||Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.|||Phosphorylated by FAM20C in the extracellular medium.|||Plasma.|||Secreted http://togogenome.org/gene/9796:LIG4 ^@ http://purl.uniprot.org/uniprot/F6X700 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9796:B3GALT2 ^@ http://purl.uniprot.org/uniprot/F7C2T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:ACTRT2 ^@ http://purl.uniprot.org/uniprot/F7DVW3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:TRMT1L ^@ http://purl.uniprot.org/uniprot/F6WG89 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||May play a role in motor coordination and exploratory behavior. http://togogenome.org/gene/9796:LOC100068926 ^@ http://purl.uniprot.org/uniprot/F6RF57 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9796:KRTAP27-1 ^@ http://purl.uniprot.org/uniprot/F6QIG4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9796:NMNAT3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RJ69 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9796:SLBP2 ^@ http://purl.uniprot.org/uniprot/I2C087 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/9796:LOC100068626 ^@ http://purl.uniprot.org/uniprot/F6VTI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:KDM4A ^@ http://purl.uniprot.org/uniprot/F7A0K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM3 histone demethylase family.|||Nucleus http://togogenome.org/gene/9796:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A9L0RN40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9796:GPR141 ^@ http://purl.uniprot.org/uniprot/F6ULD5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:BRMS1L ^@ http://purl.uniprot.org/uniprot/F7AQW8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:BAG6 ^@ http://purl.uniprot.org/uniprot/A0A9L0TGH6|||http://purl.uniprot.org/uniprot/F6ZRP5 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).|||cytosol|||extracellular exosome http://togogenome.org/gene/9796:ALKAL1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H4U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9796:TMEM14A ^@ http://purl.uniprot.org/uniprot/A0A9L0T4Q9 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9796:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A9L0R8I0 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9796:STAC3 ^@ http://purl.uniprot.org/uniprot/F6XWB7 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9796:SLC10A5 ^@ http://purl.uniprot.org/uniprot/F6PK40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9796:LOC100071971 ^@ http://purl.uniprot.org/uniprot/F7D9A5 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CCR8 ^@ http://purl.uniprot.org/uniprot/F7A6I8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:ENO1 ^@ http://purl.uniprot.org/uniprot/I3RM62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9796:LOC100065031 ^@ http://purl.uniprot.org/uniprot/A0A9L0ST84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9796:GBGT1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RIW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Membrane http://togogenome.org/gene/9796:SLU7 ^@ http://purl.uniprot.org/uniprot/A0A9L0R4V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9796:LZIC ^@ http://purl.uniprot.org/uniprot/A0A9L0RZ36 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9796:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RWH6|||http://purl.uniprot.org/uniprot/F6WVB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:BPGM ^@ http://purl.uniprot.org/uniprot/A0A9L0TPL1 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9796:DKK1 ^@ http://purl.uniprot.org/uniprot/I1W670 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9796:S1PR1 ^@ http://purl.uniprot.org/uniprot/F7BGR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:USP7 ^@ http://purl.uniprot.org/uniprot/A0A9L0SAK2 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9796:CDC45 ^@ http://purl.uniprot.org/uniprot/A0A9L0S2G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/9796:LOC100054394 ^@ http://purl.uniprot.org/uniprot/F6THX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MOCS2 ^@ http://purl.uniprot.org/uniprot/F6S763 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.|||cytosol http://togogenome.org/gene/9796:LSM3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T2N6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9796:FOXP3 ^@ http://purl.uniprot.org/uniprot/B2CXY8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:SVOPL ^@ http://purl.uniprot.org/uniprot/F7DQV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:AASS ^@ http://purl.uniprot.org/uniprot/A0A3Q2HTT4 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9796:INO80C ^@ http://purl.uniprot.org/uniprot/A0A3Q2HH98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PHOX2A ^@ http://purl.uniprot.org/uniprot/F6XD52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PPP2R2A ^@ http://purl.uniprot.org/uniprot/A0A9L0SGL1|||http://purl.uniprot.org/uniprot/F6UHP9 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9796:KIN ^@ http://purl.uniprot.org/uniprot/A0A9L0REF3 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9796:PPARGC1A ^@ http://purl.uniprot.org/uniprot/A0A9L0RX24|||http://purl.uniprot.org/uniprot/A0A9L0SM16|||http://purl.uniprot.org/uniprot/F6YR50 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9796:BCAT1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PG88|||http://purl.uniprot.org/uniprot/A0A9L0RFD1 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9796:ITGAE ^@ http://purl.uniprot.org/uniprot/A0A9L0S5S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9796:PLA2G1B ^@ http://purl.uniprot.org/uniprot/F6YYL8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9796:LOC100068025 ^@ http://purl.uniprot.org/uniprot/A0A9L0RG77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:TBCCD1 ^@ http://purl.uniprot.org/uniprot/F7B7T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/9796:MRPL17 ^@ http://purl.uniprot.org/uniprot/F6R4H9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/9796:DPT ^@ http://purl.uniprot.org/uniprot/A0A9L0S8Y9 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9796:FAM189B ^@ http://purl.uniprot.org/uniprot/A0A5F5Q020 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/9796:GJA8 ^@ http://purl.uniprot.org/uniprot/F6VG96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:CLDN19 ^@ http://purl.uniprot.org/uniprot/A0A9L0S7B4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:LOC100057541 ^@ http://purl.uniprot.org/uniprot/F7A163 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PPP2R5C ^@ http://purl.uniprot.org/uniprot/F7D9E5 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9796:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I375|||http://purl.uniprot.org/uniprot/A0A9L0RMV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9796:CXCL11 ^@ http://purl.uniprot.org/uniprot/A0A9R1SK71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9796:ITGA2 ^@ http://purl.uniprot.org/uniprot/F6RHG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9796:MIOX ^@ http://purl.uniprot.org/uniprot/F6VAM9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol oxygenase family.|||Binds 2 iron ions per subunit.|||Cytoplasm http://togogenome.org/gene/9796:ATP2A2 ^@ http://purl.uniprot.org/uniprot/Q257U4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9796:MGST2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SU54 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:LOC100051483 ^@ http://purl.uniprot.org/uniprot/A0A9L0S577 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/9796:LOC100146533 ^@ http://purl.uniprot.org/uniprot/F6ZRI4 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9796:AGT ^@ http://purl.uniprot.org/uniprot/A0A9L0T1B5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/9796:AGPAT4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LC06|||http://purl.uniprot.org/uniprot/A0A9L0TDM1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9796:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L3R9 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:FRG1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SG02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/9796:OAS1 ^@ http://purl.uniprot.org/uniprot/Q5MYI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/9796:GABRR2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PU75 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:MRPS7 ^@ http://purl.uniprot.org/uniprot/F6XZF2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9796:B3GALT1 ^@ http://purl.uniprot.org/uniprot/F6TWA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:DYDC1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LBV0 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9796:GPR68 ^@ http://purl.uniprot.org/uniprot/F6RJS3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:ZKSCAN1 ^@ http://purl.uniprot.org/uniprot/F6RYN5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:NOTCH4 ^@ http://purl.uniprot.org/uniprot/F6PHD6|||http://purl.uniprot.org/uniprot/F6SVF8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/9796:EXOC3 ^@ http://purl.uniprot.org/uniprot/F6QLI1 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9796:MSTN ^@ http://purl.uniprot.org/uniprot/Q9GM97 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted|||Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. http://togogenome.org/gene/9796:PRM1 ^@ http://purl.uniprot.org/uniprot/P15341 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the protamine P1 family.|||Chromosome|||Cross-linked by interchain disulfide bonds around the DNA-helix.|||Nucleus|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.|||Testis. http://togogenome.org/gene/9796:OAT ^@ http://purl.uniprot.org/uniprot/A0A3Q2LQ87 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9796:MAP3K8 ^@ http://purl.uniprot.org/uniprot/F7CNR6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/9796:HOXC5 ^@ http://purl.uniprot.org/uniprot/F6WR44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9796:RNF182 ^@ http://purl.uniprot.org/uniprot/F6VH97 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/9796:CDC42 ^@ http://purl.uniprot.org/uniprot/K9K202 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/9796:DNPEP ^@ http://purl.uniprot.org/uniprot/A0A5F5Q0X9 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/9796:CLDN8 ^@ http://purl.uniprot.org/uniprot/F6UMN1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:OGDHL ^@ http://purl.uniprot.org/uniprot/A0A9L0RXX6 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9796:ADRB2 ^@ http://purl.uniprot.org/uniprot/F6SWV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|||Cell membrane|||Early endosome|||Golgi apparatus|||Membrane http://togogenome.org/gene/9796:RPL34 ^@ http://purl.uniprot.org/uniprot/A0A9L0RSB6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9796:FAM219B ^@ http://purl.uniprot.org/uniprot/A0A9L0S284|||http://purl.uniprot.org/uniprot/A0A9L0TGF7 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/9796:MCM6 ^@ http://purl.uniprot.org/uniprot/F6YYN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/9796:PLSCR5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HMS4 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/9796:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TJD4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/9796:SLC25A48 ^@ http://purl.uniprot.org/uniprot/F6Y6A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:LOC100052108 ^@ http://purl.uniprot.org/uniprot/F7AX17 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/9796:ZSCAN30 ^@ http://purl.uniprot.org/uniprot/F6PLA5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:AP1G2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SIJ5 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9796:NEUROD2 ^@ http://purl.uniprot.org/uniprot/F6TBQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:GJC1 ^@ http://purl.uniprot.org/uniprot/F7CQQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:MRPS18A ^@ http://purl.uniprot.org/uniprot/A0A9L0TEX6 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9796:TOMM7 ^@ http://purl.uniprot.org/uniprot/A0A9L0RK99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9796:NOS1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HV61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOS family.|||dendritic spine|||sarcolemma http://togogenome.org/gene/9796:TECR ^@ http://purl.uniprot.org/uniprot/A0A9L0SIS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:GJB3 ^@ http://purl.uniprot.org/uniprot/A0A654ICQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9796:PTPN6 ^@ http://purl.uniprot.org/uniprot/F6U9W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9796:ALDH3B1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T2V9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9796:LOC100073320 ^@ http://purl.uniprot.org/uniprot/F6YLF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ALG14 ^@ http://purl.uniprot.org/uniprot/F7CFM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9796:SLC7A14 ^@ http://purl.uniprot.org/uniprot/F7DMJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ATG12 ^@ http://purl.uniprot.org/uniprot/F6SRW5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/9796:TMPRSS11D ^@ http://purl.uniprot.org/uniprot/F6QSG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9796:LMLN ^@ http://purl.uniprot.org/uniprot/A0A9L0TJI2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9796:MAP2K6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RM24|||http://purl.uniprot.org/uniprot/A0A9L0SV87 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/F6ZUD8|||http://purl.uniprot.org/uniprot/F7A013 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9796:SCFD2 ^@ http://purl.uniprot.org/uniprot/F6R8P0 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9796:ATG3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L0A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/9796:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H834|||http://purl.uniprot.org/uniprot/A0A3Q2HB37 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9796:TECRL ^@ http://purl.uniprot.org/uniprot/A0A9L0S5P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/9796:LOC100053672 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LRP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100630282 ^@ http://purl.uniprot.org/uniprot/F6ZRT3 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9796:RORB ^@ http://purl.uniprot.org/uniprot/A0A9L0S7I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9796:PTGR2 ^@ http://purl.uniprot.org/uniprot/F6T1P0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9796:PRPF4B ^@ http://purl.uniprot.org/uniprot/F7DW09 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/9796:RPA4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SDD0 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/9796:TMEM192 ^@ http://purl.uniprot.org/uniprot/F7BA32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM192 family.|||Late endosome|||Lysosome membrane|||Membrane http://togogenome.org/gene/9796:PRPH2 ^@ http://purl.uniprot.org/uniprot/F6WQU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9796:FMO2 ^@ http://purl.uniprot.org/uniprot/F6T988 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:LOC100068268 ^@ http://purl.uniprot.org/uniprot/F6UPS8 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SCUBE3 ^@ http://purl.uniprot.org/uniprot/F7DUY3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:CD38 ^@ http://purl.uniprot.org/uniprot/F6T4L9 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9796:RETNLB ^@ http://purl.uniprot.org/uniprot/A0A3Q2KWM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9796:BGN ^@ http://purl.uniprot.org/uniprot/O46403 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity).|||May be involved in collagen fiber assembly.|||The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.|||extracellular matrix http://togogenome.org/gene/9796:IL13RA2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GW89|||http://purl.uniprot.org/uniprot/A0A3Q2IBZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100147668 ^@ http://purl.uniprot.org/uniprot/F7AV60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:RGN ^@ http://purl.uniprot.org/uniprot/A0A3Q2HW82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9796:LOC100629456 ^@ http://purl.uniprot.org/uniprot/Q0W9P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria.|||Secreted http://togogenome.org/gene/9796:FGF10 ^@ http://purl.uniprot.org/uniprot/F7CND4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9796:NOS2 ^@ http://purl.uniprot.org/uniprot/Q9BDH6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/9796:LOC102150457 ^@ http://purl.uniprot.org/uniprot/F6RHA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:SMIM15 ^@ http://purl.uniprot.org/uniprot/F7B1M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9796:PCSK2 ^@ http://purl.uniprot.org/uniprot/F6W2D5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9796:CA6 ^@ http://purl.uniprot.org/uniprot/B7X749 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9796:ESR1 ^@ http://purl.uniprot.org/uniprot/Q9TV98 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with coactivator NCOA5. Interacts with PELP1, the interaction is enhanced by 17-beta-estradiol; the interaction increases ESR1 transcriptional activity (By similarity). Interacts with NCOA7; the interaction is ligand-inducible. Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, MAP1S, SMARD1, and UBE1C. Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ESR1-mediated transcription. Interacts with DNTTIP2, and UIMC1. Interacts with KMT2D/MLL2. Interacts with ATAD2; the interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via its C-terminus). Interacts with MACROD1. Interacts with SH2D4A and PLCG. Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with DNAAF4. Interacts with PRMT2. Interacts with RBFOX2. Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent. Interacts with FAM120B, FOXL2, PHB2 and SLC30A9. Interacts with coactivators NCOA3 and NCOA6. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D. Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy. Interacts with DDX5. Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions. Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3. Interacts with NRIP1. Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts with CLOCK and the interaction is stimulated by estrogen. Interacts with TRIP4 (ufmylated); estrogen dependent. Interacts with LMTK3; the interaction phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with ZFHX3. Interacts with SFR1 in a ligand-dependent and -independent manner. Interacts with DCAF13, LATS1 and DCAF1; regulates ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation. Interacts (via DNA-binding domain) with POU4F2 (C-terminus); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner. Interacts with ESRRB isoform 1. Interacts with UBE3A and WBP2. Interacts with GTF2B. Interacts with RBM39. In the absence of hormonal ligand, interacts with TACC1 (By similarity). Interacts with PI3KR1 or PI3KR2 and PTK2/FAK1 (By similarity). Interacts with SRC (By similarity).|||Cell membrane|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).|||Cytoplasm|||Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-260.|||Golgi apparatus|||Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades.Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).|||Nucleus|||Palmitoylated at Cys-447 by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor (By similarity).|||Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity (By similarity). Phosphorylated by LMTK3 (in vitro) (By similarity).|||Ubiquitinated; regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1. http://togogenome.org/gene/9796:PRPH ^@ http://purl.uniprot.org/uniprot/F7DQ79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||axon http://togogenome.org/gene/9796:SPTLC3 ^@ http://purl.uniprot.org/uniprot/A0A9L0S8B5|||http://purl.uniprot.org/uniprot/A0A9L0TSL6 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9796:CD163 ^@ http://purl.uniprot.org/uniprot/F7AC72 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:KCNK7 ^@ http://purl.uniprot.org/uniprot/F6RAE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9796:PDE2A ^@ http://purl.uniprot.org/uniprot/F6UGJ6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9796:GGA3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L844|||http://purl.uniprot.org/uniprot/F7AX96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9796:CYP2A13 ^@ http://purl.uniprot.org/uniprot/A9UHN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:METTL11B ^@ http://purl.uniprot.org/uniprot/F6X3I5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9796:PTTG1 ^@ http://purl.uniprot.org/uniprot/F6XRS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:MFF ^@ http://purl.uniprot.org/uniprot/A0A3Q2LA78|||http://purl.uniprot.org/uniprot/F6SLK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.|||synaptic vesicle http://togogenome.org/gene/9796:ARG1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T6I4 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9796:APOD ^@ http://purl.uniprot.org/uniprot/A0A9L0S4G9 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/9796:KEF40_p07 ^@ http://purl.uniprot.org/uniprot/P48661|||http://purl.uniprot.org/uniprot/Q6J6W9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:CHEK1 ^@ http://purl.uniprot.org/uniprot/K9KET2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9796:UBE2U ^@ http://purl.uniprot.org/uniprot/A0A9L0SX43 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9796:PIGW ^@ http://purl.uniprot.org/uniprot/F6Z393 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/9796:SLC37A2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SZC6|||http://purl.uniprot.org/uniprot/A0A9L0TLV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9796:LOC100062545 ^@ http://purl.uniprot.org/uniprot/F6VCQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CLU ^@ http://purl.uniprot.org/uniprot/Q29482 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ. Slightly acidic pH promotes interaction with misfolded proteins. Forms high-molecular weight oligomers upon interaction with misfolded proteins. Interacts with APOA1, LRP2, CLUAP1 and PON1. Interacts with the complement complex. Interacts (via alpha chain) with XRCC6. Interacts with SYVN1, COMMD1, BTRC, CUL1 and with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Interacts (via alpha chain) with BAX in stressed cells, where BAX undergoes a conformation change leading to association with the mitochondrial membrane. Does not interact with BAX in unstressed cells. Found in a complex with LTF, CLU, EPPIN and SEMG1. Interacts (immaturely glycosylated pre-secreted form) with HSPA5; this interaction promotes CLU stability and facilitates stress-induced CLU retrotranslocation from the secretory pathway to the mitochondria, thereby reducing stress-induced apoptosis by stabilizing mitochondrial membrane integrity. Interacts with BCL2L1; this interaction releases and activates BAX and promotes cell death. Interacts with TGFBR2 and ACVR1 (By similarity). Interacts (secreted form) with STMN3; this interaction may act as an important modulator during neuronal differentiation (By similarity). Interacts with VLDLR and LRP8 (By similarity).|||Belongs to the clusterin family.|||Cytoplasm|||Endoplasmic reticulum|||Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity).|||Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate. Endoplasmic reticulum (ER) stress induces changes in glycosylation status and increases level of hypoglycosylated forms. Core carbohydrates are essential for chaperone activity. Non-secreted forms are hypoglycosylated or unglycosylated.|||Microsome|||Mitochondrion|||Mitochondrion membrane|||Nucleus|||Polyubiquitinated, leading to proteasomal degradation. Under cellular stress, the intracellular level of cleaved form is reduced due to proteasomal degradation.|||Proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen. Proteolytic cleavage is not necessary for its chaperone activity. All non-secreted forms are not proteolytically cleaved. Chaperone activity of uncleaved forms is dependent on a non-reducing envoronment.|||Secreted|||chromaffin granule|||cytosol|||perinuclear region http://togogenome.org/gene/9796:PLD5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RPK4 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9796:SLCO5A1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SQW4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:LOC100063485 ^@ http://purl.uniprot.org/uniprot/F7C6B6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:STAR ^@ http://purl.uniprot.org/uniprot/O46689 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). http://togogenome.org/gene/9796:SULT2A1 ^@ http://purl.uniprot.org/uniprot/D9IPW3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:AREG ^@ http://purl.uniprot.org/uniprot/F7AX73 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ACKR1 ^@ http://purl.uniprot.org/uniprot/F7DSK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/9796:LOC100073319 ^@ http://purl.uniprot.org/uniprot/F6V5I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PGAM2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SBP2 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9796:LOC102147636 ^@ http://purl.uniprot.org/uniprot/F6W5J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:GPRC5A ^@ http://purl.uniprot.org/uniprot/F7DS71 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:LHB ^@ http://purl.uniprot.org/uniprot/P08751 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|||Microheterogeneity at Asn-33. O-glycosylation appears to be responsible for the beta subunit contribution to the difference in LH-receptor binding activity between LSH-B and CG-B.|||Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.|||Secreted http://togogenome.org/gene/9796:PAX5 ^@ http://purl.uniprot.org/uniprot/I3WD94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100069318 ^@ http://purl.uniprot.org/uniprot/A0A9L0RCJ2 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9796:CLDN9 ^@ http://purl.uniprot.org/uniprot/H9GZR1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:CIT ^@ http://purl.uniprot.org/uniprot/F6T1H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Plays a role in cytokinesis. Displays serine/threonine protein kinase activity. http://togogenome.org/gene/9796:LOC100061787 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IFZ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9796:LOC100034005 ^@ http://purl.uniprot.org/uniprot/F7BAL2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9796:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RW38|||http://purl.uniprot.org/uniprot/F6ZDF5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9796:LOC100056800 ^@ http://purl.uniprot.org/uniprot/F6X7Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CLCC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RAN1|||http://purl.uniprot.org/uniprot/F7BIM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane http://togogenome.org/gene/9796:LOC102148236 ^@ http://purl.uniprot.org/uniprot/A0A9L0RG39 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/9796:PRKACA ^@ http://purl.uniprot.org/uniprot/A0A9L0RRM6|||http://purl.uniprot.org/uniprot/A0A9L0T2N3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9796:ABLIM1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I352|||http://purl.uniprot.org/uniprot/A0A5F5PNH9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:KIF18B ^@ http://purl.uniprot.org/uniprot/F6U8L2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9796:SUPT20H ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4P8 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/9796:NR1H2 ^@ http://purl.uniprot.org/uniprot/F6TR06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9796:THRAP3 ^@ http://purl.uniprot.org/uniprot/F6U4J8 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9796:LOC100054896 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I2W9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100050706 ^@ http://purl.uniprot.org/uniprot/F7CU44 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:BLK ^@ http://purl.uniprot.org/uniprot/A0A9L0S2V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:IL18RAP ^@ http://purl.uniprot.org/uniprot/F7CCB3 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9796:LOC100051657 ^@ http://purl.uniprot.org/uniprot/Q860N7 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:SLC5A12 ^@ http://purl.uniprot.org/uniprot/F7AKS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:AOX1 ^@ http://purl.uniprot.org/uniprot/M1ZMP4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9796:LOC100057494 ^@ http://purl.uniprot.org/uniprot/F7CZH8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SIK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9796:TMEM225B ^@ http://purl.uniprot.org/uniprot/A0A9L0TQ91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:SMAD1 ^@ http://purl.uniprot.org/uniprot/F6W0G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:POLR3G ^@ http://purl.uniprot.org/uniprot/F6QYU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9796:FMN1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PP37 ^@ Similarity ^@ Belongs to the formin homology family. Cappuccino subfamily. http://togogenome.org/gene/9796:LOC100072705 ^@ http://purl.uniprot.org/uniprot/A0A9L0SQ32 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:TAS2R1 ^@ http://purl.uniprot.org/uniprot/F6PX49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9796:LOC100050797 ^@ http://purl.uniprot.org/uniprot/A0A5F5PP62 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9796:ALDH16A1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PGK1 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Interacts with SPG21. http://togogenome.org/gene/9796:HSPB3 ^@ http://purl.uniprot.org/uniprot/F6PKL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:ACSL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RWF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9796:SLC25A35 ^@ http://purl.uniprot.org/uniprot/A0A5F5PKG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:GPR158 ^@ http://purl.uniprot.org/uniprot/F7B1J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:MMS22L ^@ http://purl.uniprot.org/uniprot/A0A3Q2HWJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MMS22 family. MMS22L subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9796:STEAP1 ^@ http://purl.uniprot.org/uniprot/F6TQN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:NUTM2F ^@ http://purl.uniprot.org/uniprot/F6YCV2 ^@ Similarity ^@ Belongs to the NUT family. http://togogenome.org/gene/9796:PDE1A ^@ http://purl.uniprot.org/uniprot/A0A9L0TMB3 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9796:PDE6H ^@ http://purl.uniprot.org/uniprot/A0A5F5PJH2 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9796:TPM2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ID93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9796:MPG ^@ http://purl.uniprot.org/uniprot/A0A3Q2H1W8 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/9796:LOC100061281 ^@ http://purl.uniprot.org/uniprot/F6VAH3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:ENDOU ^@ http://purl.uniprot.org/uniprot/A0A9L0TRT8 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/9796:SLC6A17 ^@ http://purl.uniprot.org/uniprot/F6YVD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9796:SLC16A1 ^@ http://purl.uniprot.org/uniprot/Q6SJP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9796:LOC100059232 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H3T9 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9796:WFIKKN1 ^@ http://purl.uniprot.org/uniprot/F6WEE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/9796:LAP3 ^@ http://purl.uniprot.org/uniprot/F7A676 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M17 family.|||Homohexamer. http://togogenome.org/gene/9796:LOC100147487 ^@ http://purl.uniprot.org/uniprot/F7B394 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:GPR83 ^@ http://purl.uniprot.org/uniprot/F6VZL1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:ADCY9 ^@ http://purl.uniprot.org/uniprot/F6XFB9 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/9796:UNK ^@ http://purl.uniprot.org/uniprot/A0A3Q2HC77|||http://purl.uniprot.org/uniprot/A0A3Q2L6T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unkempt family.|||Cytoplasm http://togogenome.org/gene/9796:DYNLL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SKG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9796:P2RY13 ^@ http://purl.uniprot.org/uniprot/A0A9L0S8Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:TAGLN3 ^@ http://purl.uniprot.org/uniprot/F6ZBC3 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9796:RAB3C ^@ http://purl.uniprot.org/uniprot/F6ZV39|||http://purl.uniprot.org/uniprot/F7CDC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9796:ACAA2 ^@ http://purl.uniprot.org/uniprot/K9K2H8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9796:SLAIN1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IDI6 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9796:LMOD2 ^@ http://purl.uniprot.org/uniprot/A0A9L0T2Z4 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/9796:CA3 ^@ http://purl.uniprot.org/uniprot/P07450 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Cytoplasm|||Inhibited by acetazolamide.|||Reversible hydration of carbon dioxide.|||S-glutathionylated in hepatocytes under oxidative stress.|||S-thiolated both by thiol-disulfide exchange with glutathione disulfide and by oxyradical-initiated S-thiolation with reduced glutathione. http://togogenome.org/gene/9796:IL4R ^@ http://purl.uniprot.org/uniprot/Q6WG24 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.|||On IL4 binding, phosphorylated on tyrosine residues in the cytoplasmic domain.|||Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity).|||Secreted|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling. Interacts with JAK3. Interacts with CLM1. http://togogenome.org/gene/9796:CTSS ^@ http://purl.uniprot.org/uniprot/F6VUW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9796:CPNE6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H6C2 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9796:LOC100052889 ^@ http://purl.uniprot.org/uniprot/A0A9L0QXG3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:GANC ^@ http://purl.uniprot.org/uniprot/A0A9L0R6E5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9796:STX16 ^@ http://purl.uniprot.org/uniprot/A0A9L0RLM2|||http://purl.uniprot.org/uniprot/A0A9L0TF42 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9796:DOCK4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GUE6 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9796:C14H5orf30 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9796:SHQ1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TA68 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/9796:SAR1B ^@ http://purl.uniprot.org/uniprot/K9KE13 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9796:MRPL52 ^@ http://purl.uniprot.org/uniprot/A0A5F5PGS7|||http://purl.uniprot.org/uniprot/A0A9L0SSK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL52 family.|||Mitochondrion http://togogenome.org/gene/9796:UBE2E1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RFK2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9796:TMEM35A ^@ http://purl.uniprot.org/uniprot/F6S7R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9796:VAMP5 ^@ http://purl.uniprot.org/uniprot/A0A9L0T5F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9796:SLC10A3 ^@ http://purl.uniprot.org/uniprot/F7BBG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9796:INSIG1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9796:MMP26 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I1S9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9796:KCNN3 ^@ http://purl.uniprot.org/uniprot/A0A9L0TJ17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:STARD6 ^@ http://purl.uniprot.org/uniprot/A0A9R1SHL4 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/9796:CALHM4 ^@ http://purl.uniprot.org/uniprot/F7C5W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9796:HNRNPK ^@ http://purl.uniprot.org/uniprot/A0A9L0TRC2|||http://purl.uniprot.org/uniprot/F6Q4Q1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/9796:LOC100067701 ^@ http://purl.uniprot.org/uniprot/F6TQ35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:GOLGA5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KJX3 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. http://togogenome.org/gene/9796:ALG11 ^@ http://purl.uniprot.org/uniprot/F7DAI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/9796:PPARG ^@ http://purl.uniprot.org/uniprot/A0A9L0R7D5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/9796:LOC100068606 ^@ http://purl.uniprot.org/uniprot/F6V4F6 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9796:LGI3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RZL9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:STEAP3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I0Q6|||http://purl.uniprot.org/uniprot/A0A9L0T107 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9796:LOC100065068 ^@ http://purl.uniprot.org/uniprot/B5BV12 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:MRGPRF ^@ http://purl.uniprot.org/uniprot/A4UZ24 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:DPEP2 ^@ http://purl.uniprot.org/uniprot/F6PT98 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9796:FZD4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LRA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:LGB1 ^@ http://purl.uniprot.org/uniprot/P02758 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.|||Monomer.|||Secreted http://togogenome.org/gene/9796:LOC100146678 ^@ http://purl.uniprot.org/uniprot/F6X172 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HHL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9796:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PTT8 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9796:PRR5L ^@ http://purl.uniprot.org/uniprot/A0A9L0SF21 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9796:TCAF1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PQS6|||http://purl.uniprot.org/uniprot/F6S404 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/9796:LHFPL3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T308|||http://purl.uniprot.org/uniprot/A0A9L0TEN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100057251 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q2Q9 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/9796:PRDX1 ^@ http://purl.uniprot.org/uniprot/F6S6J4 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9796:ITIH2 ^@ http://purl.uniprot.org/uniprot/F7DAF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/9796:LOC100072368 ^@ http://purl.uniprot.org/uniprot/F6W6S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NDC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SNI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDC1 family.|||Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.|||Membrane|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/9796:TMEM136 ^@ http://purl.uniprot.org/uniprot/A0A9L0RQ70|||http://purl.uniprot.org/uniprot/F6ZK18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:KDELC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RQZ6 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9796:TM4SF4 ^@ http://purl.uniprot.org/uniprot/F6TR36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9796:SLC26A8 ^@ http://purl.uniprot.org/uniprot/F7CWT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9796:LOC100056866 ^@ http://purl.uniprot.org/uniprot/F7D0X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:AIFM1 ^@ http://purl.uniprot.org/uniprot/A0A5F5PMZ3 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/9796:SMIM12 ^@ http://purl.uniprot.org/uniprot/A0A452GES5|||http://purl.uniprot.org/uniprot/F6USH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM12 family.|||Membrane http://togogenome.org/gene/9796:MYOZ3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T8Z0 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9796:STAC ^@ http://purl.uniprot.org/uniprot/F6TFM8 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9796:LOC100068121 ^@ http://purl.uniprot.org/uniprot/F6UQQ2 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:DOK6 ^@ http://purl.uniprot.org/uniprot/A0A9L0TIG7 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9796:HAP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HJ87|||http://purl.uniprot.org/uniprot/A0A3Q2KR03 ^@ Subcellular Location Annotation ^@ Early endosome|||Mitochondrion http://togogenome.org/gene/9796:CAMK2A ^@ http://purl.uniprot.org/uniprot/A0A3Q2H2A7|||http://purl.uniprot.org/uniprot/F7CER2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9796:IFND2 ^@ http://purl.uniprot.org/uniprot/B6CGU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:MAP7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HNJ3|||http://purl.uniprot.org/uniprot/A0A3Q2LJ21 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/9796:DUOXA2 ^@ http://purl.uniprot.org/uniprot/F7C120 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/9796:BARHL2 ^@ http://purl.uniprot.org/uniprot/F6RUK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100070087 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HNU3 ^@ Caution|||Similarity ^@ Belongs to the seminal plasma protein family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:ACTRT3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HJJ5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:ANKRD34B ^@ http://purl.uniprot.org/uniprot/F6PK04 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9796:NCOA2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ICS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9796:TUBA1A ^@ http://purl.uniprot.org/uniprot/A0A5F5PZX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9796:LOC100146699 ^@ http://purl.uniprot.org/uniprot/A0A9L0RC22 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9796:GK ^@ http://purl.uniprot.org/uniprot/A0A3Q2HIQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/9796:EBAG9 ^@ http://purl.uniprot.org/uniprot/K9K2J2 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/9796:VDR ^@ http://purl.uniprot.org/uniprot/F6T9M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:HSD17B13 ^@ http://purl.uniprot.org/uniprot/F6QVI0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:PTPRE ^@ http://purl.uniprot.org/uniprot/F6Z6A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PIGG ^@ http://purl.uniprot.org/uniprot/A0A3Q2LE92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:MCIDAS ^@ http://purl.uniprot.org/uniprot/F6Y7R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9796:FANCC ^@ http://purl.uniprot.org/uniprot/A0A9L0T7I6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.|||DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.|||Nucleus http://togogenome.org/gene/9796:ST3GAL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SLH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9796:HSP90AA1 ^@ http://purl.uniprot.org/uniprot/Q9GKX7 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cell membrane|||Cytoplasm|||Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1. Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex. The closed form interacts (via the middle domain and TPR repeat-binding motif) with co-chaperone TSC1 (via C-terminus). Interacts with TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity. Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8. Interacts with KSR1. Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity. May interact with NWD1. Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity. Interacts with co-chaperone AHSA1 (phosphorylated on 'Tyr-223'); the interaction activates HSP90AA1 ATPase activity and results in the dissociation of TSC1 from HSP90AA1. Interacts with FLCN in the presence of FNIP1. Interacts with HSP70, STIP1 and PTGES3. Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase. Interacts with SGTA (via TPR repeats). Interacts with TTC1 (via TPR repeats). Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities. Interacts with STUB1 and SMAD3. Interacts with HSP90AB1; interaction is constitutive (By similarity). Interacts with HECTD1 (via N-terminus) (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with NLPR12 (By similarity). Interacts with PDCL3 (By similarity). Interacts with TOMM70; the interaction is required for preprotein mitochondrial import. Interacts with TOMM70, IRF3 and TBK1; the interactions are direct and mediate the association of TOMM70 with IRF3 and TBK1 (By similarity). Forms a complex with ASL, ASS1 and NOS2; the complex regulates cell-autonomous L-arginine synthesis and citrulline recycling while channeling extracellular L-arginine to nitric oxide synthesis pathway.|||ISGylated.|||In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state. Co-chaperone TSC1 promotes ATP binding and inhibits HSP90AA1 ATPase activity. Binding to phosphorylated AHSA1 promotes HSP90AA1 ATPase activity. Inhibited by geldanamycin, Ganetespib (STA-9090) and SNX-2112.|||Melanosome|||Mitochondrion|||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response.|||Nucleus|||S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.|||The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.|||Ubiquitinated via 'Lys-63'-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways. http://togogenome.org/gene/9796:LOC100072120 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I5Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:SCFD1 ^@ http://purl.uniprot.org/uniprot/F7CTQ1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9796:SLC5A3 ^@ http://purl.uniprot.org/uniprot/A0A9L0SUE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PSMC5 ^@ http://purl.uniprot.org/uniprot/K9K2M4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9796:LOC100066263 ^@ http://purl.uniprot.org/uniprot/F6YHX0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:RRP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HCH2|||http://purl.uniprot.org/uniprot/A0A9L0TSA3 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/9796:SNRPB ^@ http://purl.uniprot.org/uniprot/F6VEH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9796:LOC100629618 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H1E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:FGGY ^@ http://purl.uniprot.org/uniprot/A0A9L0TKB8 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9796:ZNF24 ^@ http://purl.uniprot.org/uniprot/F7CRC8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:SIX1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TCF3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PSMA5 ^@ http://purl.uniprot.org/uniprot/F6VEA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9796:DEFB4B ^@ http://purl.uniprot.org/uniprot/Q865P6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:TFB2M ^@ http://purl.uniprot.org/uniprot/A0A9L0REW6 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:CYP11A1 ^@ http://purl.uniprot.org/uniprot/O46515 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Interacts with FDX1/adrenodoxin.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:ITGAL ^@ http://purl.uniprot.org/uniprot/A0A9L0RIR3|||http://purl.uniprot.org/uniprot/A0A9L0RP35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9796:CDH10 ^@ http://purl.uniprot.org/uniprot/F7B2F9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PROKR2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HF37 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I9T4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9796:USP45 ^@ http://purl.uniprot.org/uniprot/F6TCV1 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9796:DPH2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SY14 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/9796:MCM7 ^@ http://purl.uniprot.org/uniprot/A0A5F5PIQ2|||http://purl.uniprot.org/uniprot/F7C432 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9796:SEPT6 ^@ http://purl.uniprot.org/uniprot/F7CIZ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9796:DDX5 ^@ http://purl.uniprot.org/uniprot/F6ZKZ4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/9796:TMEM168 ^@ http://purl.uniprot.org/uniprot/F6VHJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9796:FAR2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HEK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9796:CEBPE ^@ http://purl.uniprot.org/uniprot/F6RU48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9796:SRMS ^@ http://purl.uniprot.org/uniprot/A0A9L0RK38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane http://togogenome.org/gene/9796:KCNV2 ^@ http://purl.uniprot.org/uniprot/F6XPZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:KCNK5 ^@ http://purl.uniprot.org/uniprot/A0A9L0RKQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9796:HBB ^@ http://purl.uniprot.org/uniprot/F6RDD3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9796:SLC35E4 ^@ http://purl.uniprot.org/uniprot/F6WCU6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:COG1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IA67|||http://purl.uniprot.org/uniprot/A0A5F5PU39 ^@ Similarity ^@ Belongs to the COG1 family. http://togogenome.org/gene/9796:CENPL ^@ http://purl.uniprot.org/uniprot/A0A9L0SBZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/9796:DES ^@ http://purl.uniprot.org/uniprot/A0A3Q2LUC4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:PNPLA4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HCH7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:SFXN4 ^@ http://purl.uniprot.org/uniprot/A0A9L0T7D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/9796:GALNT5 ^@ http://purl.uniprot.org/uniprot/A0A9L0TV31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:ETNPPL ^@ http://purl.uniprot.org/uniprot/A0A9L0T6J3|||http://purl.uniprot.org/uniprot/A0A9L0TNU2|||http://purl.uniprot.org/uniprot/F6ZEX8 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9796:USH1G ^@ http://purl.uniprot.org/uniprot/F6UQZ1 ^@ Function ^@ Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9796:SLC39A10 ^@ http://purl.uniprot.org/uniprot/F7A8U5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100072633 ^@ http://purl.uniprot.org/uniprot/F7AMV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC106783049 ^@ http://purl.uniprot.org/uniprot/F7CV46 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9796:PRPF38B ^@ http://purl.uniprot.org/uniprot/F6UK93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9796:CSF2 ^@ http://purl.uniprot.org/uniprot/Q95L10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/9796:SLC39A12 ^@ http://purl.uniprot.org/uniprot/F7DSC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9796:ADNP ^@ http://purl.uniprot.org/uniprot/A0A9L0RZ26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TMEM225 ^@ http://purl.uniprot.org/uniprot/F6UIT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CWF19L1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HBD0 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9796:LOC100072662 ^@ http://purl.uniprot.org/uniprot/F6UGR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A9L0RKF9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9796:KCND2 ^@ http://purl.uniprot.org/uniprot/F6U3G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/9796:ARGLU1 ^@ http://purl.uniprot.org/uniprot/F6QJW2 ^@ Similarity ^@ Belongs to the UPF0430 family. http://togogenome.org/gene/9796:GLP2R ^@ http://purl.uniprot.org/uniprot/F7AVX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:DCAF11 ^@ http://purl.uniprot.org/uniprot/A0A9L0RC85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat LEC14B family.|||Interacts with DDB1 and CUL4A.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/9796:DGKH ^@ http://purl.uniprot.org/uniprot/A0A9L0R916 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9796:MARF1 ^@ http://purl.uniprot.org/uniprot/F7BA19 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9796:PIGC ^@ http://purl.uniprot.org/uniprot/K9K3U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9796:LOC100058927 ^@ http://purl.uniprot.org/uniprot/F6ZGC2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9796:C9 ^@ http://purl.uniprot.org/uniprot/P48770 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complement C6/C7/C8/C9 family.|||Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target membranes.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.|||Secreted|||Target cell membrane|||The structure of the human polymeric form indicates the existence of an additional disulfide bond compared to the mouse monomeric form.|||Thrombin cleaves factor C9 to produce C9a and C9b. http://togogenome.org/gene/9796:LOC102148892 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HPB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/9796:TMED7 ^@ http://purl.uniprot.org/uniprot/A0A9L0T9N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9796:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A3Q2H7S2|||http://purl.uniprot.org/uniprot/O77793 ^@ Activity Regulation|||Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Activated by cytosolic calcium, which is necessary for binding to membrane lipids. Activated by phosphorylation in response to mitogenic stimuli.|||Cytoplasm|||Golgi apparatus membrane|||Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (By similarity). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity).|||Interacts with KAT5.|||Nucleus envelope|||Phosphorylated at both Ser-505 and Ser-727 in response to mitogenic stimuli.|||The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic calcium. In the presence of phosphoinositides, regulates phospholipase A2 and lysophospholipase activities in a calcium-independent way. http://togogenome.org/gene/9796:SDC2 ^@ http://purl.uniprot.org/uniprot/F6U5M0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9796:LOC100067684 ^@ http://purl.uniprot.org/uniprot/F6VFT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:REEP2 ^@ http://purl.uniprot.org/uniprot/F6UY42 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:DZIP3 ^@ http://purl.uniprot.org/uniprot/A0A9L0QZF2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:RXFP2 ^@ http://purl.uniprot.org/uniprot/F7DJQ1 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:TMEM198 ^@ http://purl.uniprot.org/uniprot/F6U6R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9796:MOG ^@ http://purl.uniprot.org/uniprot/F6SDU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/9796:GREM2 ^@ http://purl.uniprot.org/uniprot/F6XPS4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:ACY1 ^@ http://purl.uniprot.org/uniprot/F6R8T8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/9796:RPL6 ^@ http://purl.uniprot.org/uniprot/K9KFE3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9796:NOV ^@ http://purl.uniprot.org/uniprot/A0A9L0RFQ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:BTF3 ^@ http://purl.uniprot.org/uniprot/A0A9L0TFZ6 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9796:MS4A7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I6B4 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9796:KIAA0391 ^@ http://purl.uniprot.org/uniprot/K9KBG0 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/9796:LOC100061342 ^@ http://purl.uniprot.org/uniprot/F6R411 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:GSN ^@ http://purl.uniprot.org/uniprot/Q28372 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the villin/gelsolin family.|||Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN and TMSB4X (By similarity). Interacts with the inactive form of EIF2AK2/PKR (By similarity).|||Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity).|||Comprises six structurally related gelsolin-like (G1-G6) domains, that, in a calcium-free environment, are packed together to form a compact globular structure in which the putative actin-binding sequences are not sufficiently exposed to enable binding to occur. Binding calcium may release the connections that join the N- and C-terminal halves of gelsolin, enabling each half to bind actin relatively independently. G1 and G4 bind two Ca(2+) in a type I and in a type II manner. G2, G3, G5 and G6 bind only one Ca(2+) in a type II manner. Type I Ca(2+) binding sites are shared between actin and gelsolin-like repeats G1 and G4. Type I binding governs the strength of interactions between gelsolin and actin by direct participation at the binding interface. Ca(2+) binding to G2 and G6 disrupts the interactions between G2 and G6, releases the C-terminal tail, and induces large interdomain rearrangements that result in the exposure of the F-actin-binding site on G2 and contributes to the activation of gelsolin. Binding to phosphoinositides may inhibit the severing and capping properties of gelsolin.|||cytoskeleton http://togogenome.org/gene/9796:EBP ^@ http://purl.uniprot.org/uniprot/K9K251 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:IFN-OMEGA1 ^@ http://purl.uniprot.org/uniprot/P05001 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:SLC37A3 ^@ http://purl.uniprot.org/uniprot/A0A9L0TF85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/9796:KEF40_p03 ^@ http://purl.uniprot.org/uniprot/G4RIU1|||http://purl.uniprot.org/uniprot/P48656 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 5 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:SELE ^@ http://purl.uniprot.org/uniprot/A0A9L0TFC6|||http://purl.uniprot.org/uniprot/Q95LG1 ^@ Caution|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Cell-surface glycoprotein having a role in immunoadhesion (PubMed:11529941). Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity).|||Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Up-regulated in endothelial cells after exposure to bacterial lipopolysaccharide (LPS). http://togogenome.org/gene/9796:IST1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LC76|||http://purl.uniprot.org/uniprot/F6V407 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/9796:CD93 ^@ http://purl.uniprot.org/uniprot/A0A9L0R7T6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:NXF1 ^@ http://purl.uniprot.org/uniprot/F6S7D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/9796:LOC100055773 ^@ http://purl.uniprot.org/uniprot/A0A5F5PU26 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9796:PVALB ^@ http://purl.uniprot.org/uniprot/C1L371 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9796:DUSP13 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HCD7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9796:TNMD ^@ http://purl.uniprot.org/uniprot/Q95M14 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9796:SELL ^@ http://purl.uniprot.org/uniprot/A0A3Q2IEI5|||http://purl.uniprot.org/uniprot/F7E0Z9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:LDB1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SYB7 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9796:CHRM1 ^@ http://purl.uniprot.org/uniprot/F6SLG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9796:TMEM234 ^@ http://purl.uniprot.org/uniprot/A0A9L0SV50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/9796:ATP2B3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L586|||http://purl.uniprot.org/uniprot/F6Y6Q6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:VEPH1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I853 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/9796:LOC100056436 ^@ http://purl.uniprot.org/uniprot/A0A5F5PUT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9796:IL36RN ^@ http://purl.uniprot.org/uniprot/F7C2V6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9796:LOC100072213 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I5G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:AP3M2 ^@ http://purl.uniprot.org/uniprot/A0A9L0QY95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/9796:CSNK1G3 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HVZ2|||http://purl.uniprot.org/uniprot/A0A3Q2HZS4|||http://purl.uniprot.org/uniprot/F7CH57 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9796:OXSM ^@ http://purl.uniprot.org/uniprot/F7C6A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.|||Mitochondrion http://togogenome.org/gene/9796:YIF1B ^@ http://purl.uniprot.org/uniprot/A0A3Q2I0F3|||http://purl.uniprot.org/uniprot/F6VK59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/9796:UQCC1 ^@ http://purl.uniprot.org/uniprot/K9K400 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/9796:LOC102150428 ^@ http://purl.uniprot.org/uniprot/A0A9L0SMH7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:MHCB3 ^@ http://purl.uniprot.org/uniprot/Q30484 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:TMEM218 ^@ http://purl.uniprot.org/uniprot/F6ZA06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/9796:TRAM1L1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HBF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9796:PRKCZ ^@ http://purl.uniprot.org/uniprot/A0A9L0SZ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9796:MGST1 ^@ http://purl.uniprot.org/uniprot/F6U8C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/9796:GSKIP ^@ http://purl.uniprot.org/uniprot/F6WH47 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/9796:GRHL2 ^@ http://purl.uniprot.org/uniprot/F7BG04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:AKR1C1 ^@ http://purl.uniprot.org/uniprot/Q1XAA8 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the aldo/keto reductase family.|||Cytoplasm|||Detected at low levels in preovulatory follicles. Up-regulated in preovulatory follicles during luteinization 12 to 36 hours after stimulation with human chorionic gonadotropin. Up-regulated in granulosa cells 12 to 39 hours after stimulation with human chorionic gonadotropin. Detected at low levels in corpora lutea. Detected at constant low levels in theca interna.|||Detected in follicle granulosa cells (at protein level). Detected in heart, lung, liver, kidney, stomach, uterus, testis, skeletal muscle and granulosa cells of the follicle wall.|||Monomer.|||NADP-dependent oxidoreductase that has 20-alpha-hydroxysteroid dehydrogenase activity. http://togogenome.org/gene/9796:S1PR3 ^@ http://purl.uniprot.org/uniprot/F7DUT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:NXPH2 ^@ http://purl.uniprot.org/uniprot/F6YNK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9796:EMC6 ^@ http://purl.uniprot.org/uniprot/F6QQ51 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:ARSK ^@ http://purl.uniprot.org/uniprot/F6PQA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Lysosome http://togogenome.org/gene/9796:ARL5B ^@ http://purl.uniprot.org/uniprot/F6WTX4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9796:LCAT ^@ http://purl.uniprot.org/uniprot/F6ZJP9 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9796:EXT1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T7W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:ITGA8 ^@ http://purl.uniprot.org/uniprot/F7BGF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9796:LOC100057900 ^@ http://purl.uniprot.org/uniprot/F6SXW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:CD68 ^@ http://purl.uniprot.org/uniprot/Q6UBQ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9796:STMN2 ^@ http://purl.uniprot.org/uniprot/F7CII9 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9796:ARMCX2 ^@ http://purl.uniprot.org/uniprot/F6XU55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9796:PTGES ^@ http://purl.uniprot.org/uniprot/Q8HZJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAPEG family.|||Homotrimer.|||Membrane|||Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).|||perinuclear region http://togogenome.org/gene/9796:NIM1K ^@ http://purl.uniprot.org/uniprot/F7B2C5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:TNPO2 ^@ http://purl.uniprot.org/uniprot/F7D587 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:PGK2 ^@ http://purl.uniprot.org/uniprot/Q8MIF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis.|||Monomer. http://togogenome.org/gene/9796:TCN1 ^@ http://purl.uniprot.org/uniprot/F6T7K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9796:MKNK1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IEC9|||http://purl.uniprot.org/uniprot/F6TPS7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:LOC100067869 ^@ http://purl.uniprot.org/uniprot/A0A9L0RUS5 ^@ Caution|||Function|||Similarity ^@ As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.|||Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC100146977 ^@ http://purl.uniprot.org/uniprot/F6Q8W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/9796:AQP7 ^@ http://purl.uniprot.org/uniprot/A0A9L0QZ63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:NKAIN2 ^@ http://purl.uniprot.org/uniprot/A0A9L0TQI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:MFSD5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LHS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Cell membrane|||Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.|||Membrane http://togogenome.org/gene/9796:TLR8 ^@ http://purl.uniprot.org/uniprot/A8QM58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9796:PRKCG ^@ http://purl.uniprot.org/uniprot/F7CH66 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cytoplasm|||Membrane http://togogenome.org/gene/9796:UBE2E3 ^@ http://purl.uniprot.org/uniprot/K9K3Y5|||http://purl.uniprot.org/uniprot/L7MRP4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9796:TNNI3 ^@ http://purl.uniprot.org/uniprot/Q5PYI0 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the troponin I family.|||Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1 (By similarity).|||Phosphorylated at Ser-17 and Ser-18 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-26. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylated at Ser-37 and Ser-39 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity).|||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9796:CCL22 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4T7 ^@ Similarity ^@ Belongs to the intercrine beta (chemokine CC) family. http://togogenome.org/gene/9796:NAALADL2 ^@ http://purl.uniprot.org/uniprot/A0A9L0SD28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Membrane http://togogenome.org/gene/9796:UROC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R887 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/9796:LOC100066795 ^@ http://purl.uniprot.org/uniprot/A0A9L0SXP1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:HSD17B1 ^@ http://purl.uniprot.org/uniprot/A3QRK1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A5F5PFF0 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9796:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A3Q2HW15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:PHACTR3 ^@ http://purl.uniprot.org/uniprot/A0A9L0QZY5 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9796:KLHL15 ^@ http://purl.uniprot.org/uniprot/A0A9L0R7F9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:MRRF ^@ http://purl.uniprot.org/uniprot/A0A9L0S0M7|||http://purl.uniprot.org/uniprot/K9K2A5 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9796:HPF1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0A2 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/9796:LDHB ^@ http://purl.uniprot.org/uniprot/B7XH74|||http://purl.uniprot.org/uniprot/C6L1J5 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9796:RHCG ^@ http://purl.uniprot.org/uniprot/F6Q0U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9796:S100A16 ^@ http://purl.uniprot.org/uniprot/F7C5Z7 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9796:FOPNL ^@ http://purl.uniprot.org/uniprot/F6Z319 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9796:ZSCAN22 ^@ http://purl.uniprot.org/uniprot/F6THI9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TIGD7 ^@ http://purl.uniprot.org/uniprot/F7AI66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TXN ^@ http://purl.uniprot.org/uniprot/O97508 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thioredoxin family.|||Cytoplasm|||Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (By similarity).|||In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity).|||Nucleus|||Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).|||Secreted http://togogenome.org/gene/9796:EHD3 ^@ http://purl.uniprot.org/uniprot/F7CVS4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9796:TINAGL1 ^@ http://purl.uniprot.org/uniprot/F7CC59 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9796:LOC100058903 ^@ http://purl.uniprot.org/uniprot/F6QKB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:NAP1L4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SM15 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9796:PPIP5K2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PZY6|||http://purl.uniprot.org/uniprot/F6Z6W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9796:UBLCP1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R8C1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:C8H18orf32 ^@ http://purl.uniprot.org/uniprot/A0A9L0TB42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UPF0729 family.|||Interacts with DERL1 and AMFR.|||Lipid droplet|||May activate the NF-kappa-B signaling pathway. http://togogenome.org/gene/9796:PSKH1 ^@ http://purl.uniprot.org/uniprot/F6X9W0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:UTS2B ^@ http://purl.uniprot.org/uniprot/A0A5F5PHA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/9796:ADTRP ^@ http://purl.uniprot.org/uniprot/A0A3Q2HFH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/9796:RELL2 ^@ http://purl.uniprot.org/uniprot/F7CFS4 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9796:GPR37L1 ^@ http://purl.uniprot.org/uniprot/F7BKR9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:SCN1B ^@ http://purl.uniprot.org/uniprot/A0A9L0S9T7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:LOC100630489 ^@ http://purl.uniprot.org/uniprot/F6RMK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9796:JPT1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S7U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:LOC100059533 ^@ http://purl.uniprot.org/uniprot/A0A9L0TQI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GST superfamily. Pi family.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Nucleus http://togogenome.org/gene/9796:GRIA2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HVY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9796:THOC7 ^@ http://purl.uniprot.org/uniprot/F7C615 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/9796:DNAJC27 ^@ http://purl.uniprot.org/uniprot/F6QPG4 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/9796:TPI1 ^@ http://purl.uniprot.org/uniprot/F6TZS9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/9796:TMEM8B ^@ http://purl.uniprot.org/uniprot/A0A9L0SLD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:SOAT2 ^@ http://purl.uniprot.org/uniprot/F7E413 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:CACNB1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GZ79|||http://purl.uniprot.org/uniprot/A0A3Q2H9X2|||http://purl.uniprot.org/uniprot/A0A9L0S8K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/9796:CPT1A ^@ http://purl.uniprot.org/uniprot/Q68Y62 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A conformation change in the N-terminal region spanning the first 42 residues plays an important role in the regulation of enzyme activity by malonyl-CoA.|||Belongs to the carnitine/choline acetyltransferase family.|||Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (By similarity). Plays an important role in hepatic triglyceride metabolism (By similarity).|||Homohexamer and homotrimer (By similarity). Identified in a complex that contains at least CPT1A, ACSL1 and VDAC1 (By similarity). Also identified in complexes with ACSL1 and VDAC2 and VDAC3 (By similarity).|||Mitochondrion outer membrane http://togogenome.org/gene/9796:MPC1L ^@ http://purl.uniprot.org/uniprot/F6XQY9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:NR1D1 ^@ http://purl.uniprot.org/uniprot/F7A331 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9796:LOC100067739 ^@ http://purl.uniprot.org/uniprot/F6ZEP5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:SLC25A30 ^@ http://purl.uniprot.org/uniprot/A0A9L0TET1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9796:HEXA ^@ http://purl.uniprot.org/uniprot/A0A5F5PPC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/9796:CLRN1 ^@ http://purl.uniprot.org/uniprot/A0A9L0TNK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9796:CXXC5 ^@ http://purl.uniprot.org/uniprot/A0A9L0R954 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9796:CASP3 ^@ http://purl.uniprot.org/uniprot/K9KC06 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9796:CLSPN ^@ http://purl.uniprot.org/uniprot/A0A3Q2HGI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100073265 ^@ http://purl.uniprot.org/uniprot/A0A9L0R124 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9796:AQP6 ^@ http://purl.uniprot.org/uniprot/A0A5F5PU32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:ETV5 ^@ http://purl.uniprot.org/uniprot/A0A9L0S3D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:PTPN4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HYA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9796:FERMT3 ^@ http://purl.uniprot.org/uniprot/A0A5F5PTW4 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/9796:POLH ^@ http://purl.uniprot.org/uniprot/F6SCT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:LOC100059532 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HC51 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/9796:CHL1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4G5|||http://purl.uniprot.org/uniprot/A0A3Q2IJM1|||http://purl.uniprot.org/uniprot/F6QXE4 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9796:CCKBR ^@ http://purl.uniprot.org/uniprot/F6S229 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:DPH1 ^@ http://purl.uniprot.org/uniprot/F6YVY5 ^@ Similarity ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily. http://togogenome.org/gene/9796:LOC100061533 ^@ http://purl.uniprot.org/uniprot/F6TPA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ANKS1B ^@ http://purl.uniprot.org/uniprot/A0A9L0T9K4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9796:DDX31 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H7X3 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/9796:FN3K ^@ http://purl.uniprot.org/uniprot/F6UZE0 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/9796:AGBL2 ^@ http://purl.uniprot.org/uniprot/F7AV20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9796:PAX3 ^@ http://purl.uniprot.org/uniprot/F7DM34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9796:LOC100058753 ^@ http://purl.uniprot.org/uniprot/F6SL41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S9Y4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9796:COL4A5 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNY4|||http://purl.uniprot.org/uniprot/A0A9L0TKT9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9796:ICAM2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S7C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9796:PSMB7 ^@ http://purl.uniprot.org/uniprot/K9K2G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:TMEM106B ^@ http://purl.uniprot.org/uniprot/A0A9L0RCV8 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9796:LOC100065558 ^@ http://purl.uniprot.org/uniprot/F6Q0G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9796:SPA17 ^@ http://purl.uniprot.org/uniprot/F6U860 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. http://togogenome.org/gene/9796:LYRM2 ^@ http://purl.uniprot.org/uniprot/F6QST0 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9796:KDR ^@ http://purl.uniprot.org/uniprot/A0A9L0SAB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:PTOV1 ^@ http://purl.uniprot.org/uniprot/A0A9L0R050 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.|||Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.|||Cell membrane|||Cytoplasm|||May interact with CREBBP. Interacts with FLOT1.|||Nucleus|||perinuclear region http://togogenome.org/gene/9796:MOK ^@ http://purl.uniprot.org/uniprot/A0A3Q2I9C3|||http://purl.uniprot.org/uniprot/A0A9L0T025 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9796:HK3 ^@ http://purl.uniprot.org/uniprot/F6Z3G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hexokinase family.|||Membrane|||Mitochondrion outer membrane|||cytosol http://togogenome.org/gene/9796:MAT1A ^@ http://purl.uniprot.org/uniprot/F6S3W6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9796:LOC100068228 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HF90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:EMC1 ^@ http://purl.uniprot.org/uniprot/F6U072 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:LOC100629841 ^@ http://purl.uniprot.org/uniprot/F6SN30 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:LOC100055360 ^@ http://purl.uniprot.org/uniprot/A0A9L0TMC1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:CYP3A97 ^@ http://purl.uniprot.org/uniprot/C9WMG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:PDK4 ^@ http://purl.uniprot.org/uniprot/A0A9L0QYD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9796:BBOX1 ^@ http://purl.uniprot.org/uniprot/F6PZ55 ^@ Function|||Similarity ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine. http://togogenome.org/gene/9796:UBE2D1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KWY6|||http://purl.uniprot.org/uniprot/A0A9L0SCN0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9796:CDSN ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWT4 ^@ Function|||Subcellular Location Annotation ^@ Important for the epidermal barrier integrity.|||Secreted http://togogenome.org/gene/9796:SUPT5H ^@ http://purl.uniprot.org/uniprot/A0A3Q2HQ12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/9796:TROVE2 ^@ http://purl.uniprot.org/uniprot/F7AA69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9796:CCL5 ^@ http://purl.uniprot.org/uniprot/B3VH89|||http://purl.uniprot.org/uniprot/Q8MKD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.|||Secreted http://togogenome.org/gene/9796:CDH18 ^@ http://purl.uniprot.org/uniprot/F7BLF0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/F6Z8H7 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9796:MTMR4 ^@ http://purl.uniprot.org/uniprot/A0A9L0SAM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9796:SORD ^@ http://purl.uniprot.org/uniprot/F7A1C3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Binds 1 or 2 Zn(2+) ions per subunit.|||Homotetramer.|||Mitochondrion membrane|||Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.|||flagellum http://togogenome.org/gene/9796:C1H10orf53 ^@ http://purl.uniprot.org/uniprot/F6T880 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9796:CRTC2 ^@ http://purl.uniprot.org/uniprot/F6VNN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TORC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:GMNN ^@ http://purl.uniprot.org/uniprot/A0A9L0RRD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9796:NAPG ^@ http://purl.uniprot.org/uniprot/A0A9L0SJV1|||http://purl.uniprot.org/uniprot/A0A9L0TM43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/9796:WDR44 ^@ http://purl.uniprot.org/uniprot/A0A9L0RN05|||http://purl.uniprot.org/uniprot/F6RVA2 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9796:SLC35C2 ^@ http://purl.uniprot.org/uniprot/F6Q4W4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:RAB18 ^@ http://purl.uniprot.org/uniprot/K9K3M3 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9796:P2RY2 ^@ http://purl.uniprot.org/uniprot/F6SV44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:BEST4 ^@ http://purl.uniprot.org/uniprot/F7DLA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/9796:DCLK1 ^@ http://purl.uniprot.org/uniprot/F7C3P7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9796:STOML1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2L233 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9796:SVIL ^@ http://purl.uniprot.org/uniprot/A0A3Q2H421 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9796:EFNA3 ^@ http://purl.uniprot.org/uniprot/F6Z1K6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9796:PPAT ^@ http://purl.uniprot.org/uniprot/A0A3Q2HYL9 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9796:ADAMTS12 ^@ http://purl.uniprot.org/uniprot/A0A9L0TQ38 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9796:ENAH ^@ http://purl.uniprot.org/uniprot/F6U2I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||cytoskeleton http://togogenome.org/gene/9796:HM13 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KKI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9796:TEF ^@ http://purl.uniprot.org/uniprot/A0A9L0T2L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9796:SRD5A2 ^@ http://purl.uniprot.org/uniprot/F6YAW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Membrane|||Microsome membrane http://togogenome.org/gene/9796:METTL4 ^@ http://purl.uniprot.org/uniprot/A0A5F5PS09 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9796:NLRP14 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H3B9 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/9796:LOC100069973 ^@ http://purl.uniprot.org/uniprot/F6WXM7 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9796:MAPK10 ^@ http://purl.uniprot.org/uniprot/A0A5F5PKH3|||http://purl.uniprot.org/uniprot/A0A9L0RJ35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9796:C2H1orf158 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H0P9 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9796:SERPINB7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KMP9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9796:DGUOK ^@ http://purl.uniprot.org/uniprot/F7APZ2 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9796:LOC100630699 ^@ http://purl.uniprot.org/uniprot/A0A9L0RK65 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9796:IP6K3 ^@ http://purl.uniprot.org/uniprot/F6YJJ0 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9796:CDC6 ^@ http://purl.uniprot.org/uniprot/F7B3A5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/9796:SLC16A3 ^@ http://purl.uniprot.org/uniprot/A5JST7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9796:CXCR4 ^@ http://purl.uniprot.org/uniprot/A0A9L0T842 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane http://togogenome.org/gene/9796:MMACHC ^@ http://purl.uniprot.org/uniprot/F6U012 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/9796:RPSA ^@ http://purl.uniprot.org/uniprot/B8K1X7 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9796:GFM2 ^@ http://purl.uniprot.org/uniprot/F7E130 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.|||Mitochondrion http://togogenome.org/gene/9796:WNT3 ^@ http://purl.uniprot.org/uniprot/F6Y115 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9796:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GSS3|||http://purl.uniprot.org/uniprot/A0A9R1SI73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9796:FAM208B ^@ http://purl.uniprot.org/uniprot/A0A3Q2HGT6|||http://purl.uniprot.org/uniprot/A0A5F5PS87 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/9796:KCNJ8 ^@ http://purl.uniprot.org/uniprot/F6Z3I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9796:OPN1LW ^@ http://purl.uniprot.org/uniprot/O18912 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.|||The three color pigments are found in the cone photoreceptor cells. Expressed in retina (PubMed:10511567).|||Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. http://togogenome.org/gene/9796:FBXO9 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HT68 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9796:GAPDH ^@ http://purl.uniprot.org/uniprot/Q9TUX5 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9796:TAF15 ^@ http://purl.uniprot.org/uniprot/A0A9L0RS79|||http://purl.uniprot.org/uniprot/F7DSE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9796:S1PR2 ^@ http://purl.uniprot.org/uniprot/F6S391 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:TUSC3 ^@ http://purl.uniprot.org/uniprot/A0A5F5PG47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:LOC100053645 ^@ http://purl.uniprot.org/uniprot/A0A9L0SXI9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HSZ2|||http://purl.uniprot.org/uniprot/A0A3Q2I8T4|||http://purl.uniprot.org/uniprot/A0A3Q2L9N3|||http://purl.uniprot.org/uniprot/A0A9L0T5Z4|||http://purl.uniprot.org/uniprot/F7D1R8 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9796:GPAT2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HKJ8 ^@ Similarity ^@ Belongs to the GPAT/DAPAT family. http://togogenome.org/gene/9796:AGPAT1 ^@ http://purl.uniprot.org/uniprot/A0A9L0RUL9 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9796:WASHC5 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H5H4 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/9796:LHFPL1 ^@ http://purl.uniprot.org/uniprot/F6TUC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:ARMC1 ^@ http://purl.uniprot.org/uniprot/F6X3R8|||http://purl.uniprot.org/uniprot/L7MS15 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9796:ACKR2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RDV4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9796:AFM ^@ http://purl.uniprot.org/uniprot/F7B3I5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:SP4 ^@ http://purl.uniprot.org/uniprot/A0A9L0TTG9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TMBIM6 ^@ http://purl.uniprot.org/uniprot/F7BJX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9796:DEFB128 ^@ http://purl.uniprot.org/uniprot/F7BFI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9796:GNGT1 ^@ http://purl.uniprot.org/uniprot/F7B1I8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9796:PSMC1 ^@ http://purl.uniprot.org/uniprot/F6WJB5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9796:TAP1 ^@ http://purl.uniprot.org/uniprot/F6TVN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.|||Membrane http://togogenome.org/gene/9796:LOC100056182 ^@ http://purl.uniprot.org/uniprot/A0A9L0RRE3 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9796:SLC30A8 ^@ http://purl.uniprot.org/uniprot/F6S343 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9796:CCR7 ^@ http://purl.uniprot.org/uniprot/F6SPH5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:LTV1 ^@ http://purl.uniprot.org/uniprot/F7DC99 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/9796:SLC25A39 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IHW2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9796:LOC100071748 ^@ http://purl.uniprot.org/uniprot/F7AE50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:C12H11orf49 ^@ http://purl.uniprot.org/uniprot/A0A9L0TPF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/9796:SCRN3 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q0L2|||http://purl.uniprot.org/uniprot/A0A9L0TL78 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9796:METAP2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HPK6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. http://togogenome.org/gene/9796:ATRAID ^@ http://purl.uniprot.org/uniprot/A0A9L0SMG4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:CSN3 ^@ http://purl.uniprot.org/uniprot/P82187 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the kappa-casein family.|||Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.|||Mammary gland specific. Secreted in milk.|||Secreted http://togogenome.org/gene/9796:FAM198A ^@ http://purl.uniprot.org/uniprot/A0A9L0SVL1 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/9796:TACR2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LP44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9796:TIMM17A ^@ http://purl.uniprot.org/uniprot/A0A9R1SLI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:LOC100068387 ^@ http://purl.uniprot.org/uniprot/F6UP85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:MRPL36 ^@ http://purl.uniprot.org/uniprot/F7DW74 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/9796:CXCL6 ^@ http://purl.uniprot.org/uniprot/F6S9Z1|||http://purl.uniprot.org/uniprot/K9KDT0|||http://purl.uniprot.org/uniprot/Q8MIN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity).|||Secreted http://togogenome.org/gene/9796:GPT2 ^@ http://purl.uniprot.org/uniprot/A0A9L0S1X9 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/9796:ALKAL2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I4Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9796:DDX6 ^@ http://purl.uniprot.org/uniprot/F7CXI1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9796:DOCK2 ^@ http://purl.uniprot.org/uniprot/F6R9H6 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9796:OXCT1 ^@ http://purl.uniprot.org/uniprot/H1ADS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Mitochondrion http://togogenome.org/gene/9796:MELK ^@ http://purl.uniprot.org/uniprot/A0A9L0RIG9|||http://purl.uniprot.org/uniprot/A0A9L0TJA7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9796:ERMAP ^@ http://purl.uniprot.org/uniprot/A0A9L0TJ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/9796:PCNX3 ^@ http://purl.uniprot.org/uniprot/A0A9L0STN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9796:FTSJ3 ^@ http://purl.uniprot.org/uniprot/F6SYP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Interacts with NIP7.|||Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.|||nucleolus http://togogenome.org/gene/9796:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HK08|||http://purl.uniprot.org/uniprot/F6WL34 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9796:DRAM2 ^@ http://purl.uniprot.org/uniprot/F7BHE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:GRB2 ^@ http://purl.uniprot.org/uniprot/L7MSX1 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus http://togogenome.org/gene/9796:LOC100054146 ^@ http://purl.uniprot.org/uniprot/A0A9L0RFX3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:SCML4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HG08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9796:CTNNA2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PNL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/9796:HOXA1 ^@ http://purl.uniprot.org/uniprot/F6YY78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9796:LOC102150493 ^@ http://purl.uniprot.org/uniprot/A0A9L0RZN3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:WNT2 ^@ http://purl.uniprot.org/uniprot/Q2QLA5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||extracellular matrix http://togogenome.org/gene/9796:HS3ST1 ^@ http://purl.uniprot.org/uniprot/F6VH42 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9796:MRPL24 ^@ http://purl.uniprot.org/uniprot/A0A9L0QX74 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9796:PTGS1 ^@ http://purl.uniprot.org/uniprot/F7BQR7 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:CRYBA2 ^@ http://purl.uniprot.org/uniprot/F7CVJ6 ^@ Function|||Similarity ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens. http://togogenome.org/gene/9796:KRT23 ^@ http://purl.uniprot.org/uniprot/A0A3Q2KP58 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9796:LOC100068895 ^@ http://purl.uniprot.org/uniprot/A0A1K0FUK6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9796:KAT7 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HQZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9796:UNC5C ^@ http://purl.uniprot.org/uniprot/A0A9L0TCI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9796:ST7L ^@ http://purl.uniprot.org/uniprot/A0A9L0SCI2|||http://purl.uniprot.org/uniprot/A0A9L0TLL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9796:NME2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PRI0 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9796:LOC100060388 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IDB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Cell membrane|||Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids, as well as bile acids, driven by an outward gradient of dicarboxylates such as glutarate or succinate (By similarity). Transports taurocholate, estrone 3-sulfate, and estradiol-17-glucuronide (17beta-estradiol 17-O-(beta-D-glucuronate)), but not androstanediol glucuronide (5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)) (PubMed:31553721). http://togogenome.org/gene/9796:PRKAA2 ^@ http://purl.uniprot.org/uniprot/Q2LGF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:MYOC ^@ http://purl.uniprot.org/uniprot/F6QKR7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC100058071 ^@ http://purl.uniprot.org/uniprot/F7AB52 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/9796:PTGER3 ^@ http://purl.uniprot.org/uniprot/A0A9L0RRR9|||http://purl.uniprot.org/uniprot/A0A9L0SSN7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:PPFIBP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IAJ5 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/9796:DLGAP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IDG6|||http://purl.uniprot.org/uniprot/A0A5F5PHZ9|||http://purl.uniprot.org/uniprot/F6ZYR8 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9796:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GY51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/9796:PKM ^@ http://purl.uniprot.org/uniprot/B3IVM0|||http://purl.uniprot.org/uniprot/B3IVM1 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9796:TADA3 ^@ http://purl.uniprot.org/uniprot/F7CTJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9796:PGM2 ^@ http://purl.uniprot.org/uniprot/A0A3Q2GWI8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9796:LOC100063291 ^@ http://purl.uniprot.org/uniprot/A0A9L0SCW1|||http://purl.uniprot.org/uniprot/A0A9L0T976 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9796:MYBL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SH43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:POLE ^@ http://purl.uniprot.org/uniprot/A0A9L0T8N5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||DNA polymerase II participates in chromosomal DNA replication.|||Nucleus http://togogenome.org/gene/9796:LOC100053760 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I6W0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100629885 ^@ http://purl.uniprot.org/uniprot/A0A5F5PGA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9796:FOXC2 ^@ http://purl.uniprot.org/uniprot/A2SZB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:TRIQK ^@ http://purl.uniprot.org/uniprot/A0A3Q2HHL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9796:LY49B ^@ http://purl.uniprot.org/uniprot/Q75XS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:G6PC ^@ http://purl.uniprot.org/uniprot/F7CY60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9796:DHRS7C ^@ http://purl.uniprot.org/uniprot/F7AS64 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:FAM124B ^@ http://purl.uniprot.org/uniprot/F7DQ23 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9796:RELL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SAA0|||http://purl.uniprot.org/uniprot/F6V8T3 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9796:LOC100054211 ^@ http://purl.uniprot.org/uniprot/A0A3Q2ID58 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:GSTA3 ^@ http://purl.uniprot.org/uniprot/M9ZT87 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/9796:PREPL ^@ http://purl.uniprot.org/uniprot/F7B4K4 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/9796:GFOD1 ^@ http://purl.uniprot.org/uniprot/F6ZHY6 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9796:YWHAZ ^@ http://purl.uniprot.org/uniprot/F6XEB4 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9796:PRPF19 ^@ http://purl.uniprot.org/uniprot/F7CE01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9796:KCNE2 ^@ http://purl.uniprot.org/uniprot/A0A5F5PS77 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9796:RDH5 ^@ http://purl.uniprot.org/uniprot/F7CLW5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9796:TACC1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SK01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/9796:PHF1 ^@ http://purl.uniprot.org/uniprot/F6XCW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9796:FAM118A ^@ http://purl.uniprot.org/uniprot/A0A3Q2H557 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9796:SOD2 ^@ http://purl.uniprot.org/uniprot/Q9XS41 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).|||Belongs to the iron/manganese superoxide dismutase family.|||Binds 1 Mn(2+) ion per subunit.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix|||Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.|||Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. http://togogenome.org/gene/9796:FAM126A ^@ http://purl.uniprot.org/uniprot/F7CPS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9796:UBE2K ^@ http://purl.uniprot.org/uniprot/A0A5F5PTZ6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9796:UNC93A ^@ http://purl.uniprot.org/uniprot/F6SCS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/9796:ACTR10 ^@ http://purl.uniprot.org/uniprot/A0A5F5PR33|||http://purl.uniprot.org/uniprot/A0A9L0T4T5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9796:MRPS5 ^@ http://purl.uniprot.org/uniprot/F6TA96 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/9796:LITAF ^@ http://purl.uniprot.org/uniprot/Q8MKD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9796:LOC100056903 ^@ http://purl.uniprot.org/uniprot/A0A9L0TFE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:ADAM9 ^@ http://purl.uniprot.org/uniprot/F7D9Z8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LNPK ^@ http://purl.uniprot.org/uniprot/A0A3Q2HTJ9|||http://purl.uniprot.org/uniprot/F6WGZ3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/9796:PHB ^@ http://purl.uniprot.org/uniprot/F6SXD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9796:PARPBP ^@ http://purl.uniprot.org/uniprot/F6YLY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:HS6ST2 ^@ http://purl.uniprot.org/uniprot/A0A5F5Q1U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/9796:THNSL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0S567 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/9796:CNOT6 ^@ http://purl.uniprot.org/uniprot/A0A9L0RXI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9796:PKIG ^@ http://purl.uniprot.org/uniprot/A0A9L0T8X4 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9796:LOC100054424 ^@ http://purl.uniprot.org/uniprot/F7B9F5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:CSF3 ^@ http://purl.uniprot.org/uniprot/Q8MKE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.|||Monomer.|||Secreted http://togogenome.org/gene/9796:CFB ^@ http://purl.uniprot.org/uniprot/A0A3Q2IDD2 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9796:C5H1orf52 ^@ http://purl.uniprot.org/uniprot/A0A9L0R360 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/9796:GPR55 ^@ http://purl.uniprot.org/uniprot/A0A9L0SMS3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:RMI1 ^@ http://purl.uniprot.org/uniprot/A0A9L0SAH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9796:SLC25A5 ^@ http://purl.uniprot.org/uniprot/K9KEM4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9796:HCAR2 ^@ http://purl.uniprot.org/uniprot/A0A9L0RTR4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:GLRA2 ^@ http://purl.uniprot.org/uniprot/F7AQJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9796:OGDH ^@ http://purl.uniprot.org/uniprot/A0A9L0RI99|||http://purl.uniprot.org/uniprot/F6WSG0 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9796:TSPAN3 ^@ http://purl.uniprot.org/uniprot/K9KE98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:CYP3A95 ^@ http://purl.uniprot.org/uniprot/D7GB58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9796:ELOC ^@ http://purl.uniprot.org/uniprot/F7D5C0 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9796:HEXIM1 ^@ http://purl.uniprot.org/uniprot/F7DSW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9796:SEMA7A ^@ http://purl.uniprot.org/uniprot/F7C7V8 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:LOC100056271 ^@ http://purl.uniprot.org/uniprot/F6WR26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Putative odorant or sperm cell receptor. http://togogenome.org/gene/9796:LOC100052533 ^@ http://purl.uniprot.org/uniprot/F6VJ01 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/9796:TCEANC2 ^@ http://purl.uniprot.org/uniprot/A0A9R1SHQ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:PLPP3 ^@ http://purl.uniprot.org/uniprot/A0A9L0T6W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9796:LOC100053279 ^@ http://purl.uniprot.org/uniprot/A0A9L0T973 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9796:GPR33 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LJ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Membrane http://togogenome.org/gene/9796:CERS6 ^@ http://purl.uniprot.org/uniprot/A0A3Q2H6T3|||http://purl.uniprot.org/uniprot/A0A3Q2H814 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9796:PLAU ^@ http://purl.uniprot.org/uniprot/A0A9L0TAU7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9796:KIAA1024L ^@ http://purl.uniprot.org/uniprot/F7CEH4 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/9796:ALG5 ^@ http://purl.uniprot.org/uniprot/A0A9L0SQ24 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9796:GPRC5C ^@ http://purl.uniprot.org/uniprot/A0A9L0SH10 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:DCST2 ^@ http://purl.uniprot.org/uniprot/F7DZK9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9796:GPLD1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2LG05|||http://purl.uniprot.org/uniprot/A0A9L0T6J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/9796:PON1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T0M3 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/9796:PRPF18 ^@ http://purl.uniprot.org/uniprot/K9K9R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9796:CALCA ^@ http://purl.uniprot.org/uniprot/Q9N0T2|||http://purl.uniprot.org/uniprot/Q9N0V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity).|||Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.|||Secreted http://togogenome.org/gene/9796:GPR20 ^@ http://purl.uniprot.org/uniprot/F7A186 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9796:NACC1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2IAI6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9796:GPRC5D ^@ http://purl.uniprot.org/uniprot/A0A3Q2IE57|||http://purl.uniprot.org/uniprot/F6TWK3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9796:NUSAP1 ^@ http://purl.uniprot.org/uniprot/A0A3Q2I421|||http://purl.uniprot.org/uniprot/F6XQL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NUSAP family.|||Cytoplasm http://togogenome.org/gene/9796:PIGK ^@ http://purl.uniprot.org/uniprot/K9K2C5 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C13 family.|||Forms a complex with PIGT, PIGS, PIGU and GAA1. http://togogenome.org/gene/9796:PPIB ^@ http://purl.uniprot.org/uniprot/A5YBL8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9796:BMP15 ^@ http://purl.uniprot.org/uniprot/F6V249 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9796:EIF4G3 ^@ http://purl.uniprot.org/uniprot/Q6RZX2 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9796:MYF5 ^@ http://purl.uniprot.org/uniprot/A0A090AMY3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9796:GABRB3 ^@ http://purl.uniprot.org/uniprot/F6ZJU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9796:LOC102150542 ^@ http://purl.uniprot.org/uniprot/A0A3Q2HLK8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9796:PLAC1 ^@ http://purl.uniprot.org/uniprot/F7A600 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9796:ITGA3 ^@ http://purl.uniprot.org/uniprot/F6W8D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9796:LOC100064378 ^@ http://purl.uniprot.org/uniprot/A0A5F5PW36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9796:OPRL1 ^@ http://purl.uniprot.org/uniprot/A0A9L0T4T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/9796:TMEM86A ^@ http://purl.uniprot.org/uniprot/A0A3Q2H2Z4|||http://purl.uniprot.org/uniprot/A0A5F5PTB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9796:BTF3L4 ^@ http://purl.uniprot.org/uniprot/K9KCW6 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9796:LTF ^@ http://purl.uniprot.org/uniprot/A0A3Q2HKG3 ^@ Similarity ^@ Belongs to the transferrin family. http://togogenome.org/gene/9796:BNIP3L ^@ http://purl.uniprot.org/uniprot/F6ZEA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/9796:LOC100073113 ^@ http://purl.uniprot.org/uniprot/F7A5C0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family.