http://togogenome.org/gene/118200:DRD1 ^@ http://purl.uniprot.org/uniprot/A0A093GUM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:SARM1 ^@ http://purl.uniprot.org/uniprot/A0A093GRU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SARM1 family.|||axon http://togogenome.org/gene/118200:NEUROD6 ^@ http://purl.uniprot.org/uniprot/A0A093IV43 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:TAT ^@ http://purl.uniprot.org/uniprot/A0A093H2N2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/118200:EPYC ^@ http://purl.uniprot.org/uniprot/A0A093IXS3 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/118200:DESI1 ^@ http://purl.uniprot.org/uniprot/A0A093GI16 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/118200:SLC12A1 ^@ http://purl.uniprot.org/uniprot/A0A093GDN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/118200:ARL4C ^@ http://purl.uniprot.org/uniprot/A0A093FXI3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/118200:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A093G5H7 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/118200:MTNR1A ^@ http://purl.uniprot.org/uniprot/A0A093GEJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:STX16 ^@ http://purl.uniprot.org/uniprot/A0A093GRH4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/118200:LOC104298437 ^@ http://purl.uniprot.org/uniprot/A0A093G9L3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:CLRN3 ^@ http://purl.uniprot.org/uniprot/A0A093H065 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/118200:FGF6 ^@ http://purl.uniprot.org/uniprot/A0A093GD06 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/118200:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/A0A093IWM7 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/118200:ITPA ^@ http://purl.uniprot.org/uniprot/A0A093GF92 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/118200:CDH7 ^@ http://purl.uniprot.org/uniprot/A0A093FX27 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/118200:HHATL ^@ http://purl.uniprot.org/uniprot/A0A093G5N3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:MSTN ^@ http://purl.uniprot.org/uniprot/A0A093FZY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/118200:TLX1 ^@ http://purl.uniprot.org/uniprot/A0A093J6Q0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:TDO2 ^@ http://purl.uniprot.org/uniprot/A0A093FXI2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:LIG4 ^@ http://purl.uniprot.org/uniprot/A0A093GGB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/118200:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A093IVA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/118200:PHYHIPL ^@ http://purl.uniprot.org/uniprot/A0A093IXZ2 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/118200:GJA1 ^@ http://purl.uniprot.org/uniprot/A0A093H3N9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/118200:TMEM33 ^@ http://purl.uniprot.org/uniprot/A0A093G8L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/118200:MED10 ^@ http://purl.uniprot.org/uniprot/A0A093GRN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/118200:HSDL1 ^@ http://purl.uniprot.org/uniprot/A0A093II38 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/118200:ODR4 ^@ http://purl.uniprot.org/uniprot/A0A093GQB2 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/118200:PTGS2 ^@ http://purl.uniprot.org/uniprot/A0A093G8K9 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:POMK ^@ http://purl.uniprot.org/uniprot/A0A093IVG9 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/118200:ACTA1 ^@ http://purl.uniprot.org/uniprot/A0A093GLM6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/118200:LOC104306702 ^@ http://purl.uniprot.org/uniprot/A0A093J4J0 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/118200:LSM5 ^@ http://purl.uniprot.org/uniprot/A0A093G912 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/118200:LOC104304684 ^@ http://purl.uniprot.org/uniprot/A0A093GVI7 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/118200:SPARC ^@ http://purl.uniprot.org/uniprot/A0A093G3I6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/118200:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A093GC64 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/118200:SELENOK ^@ http://purl.uniprot.org/uniprot/A0A093FYT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein K family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/118200:EFL1 ^@ http://purl.uniprot.org/uniprot/A0A093GSE3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:SLC52A3 ^@ http://purl.uniprot.org/uniprot/A0A093GGN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/118200:HTR2A ^@ http://purl.uniprot.org/uniprot/A0A093GX91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/118200:PDE6B ^@ http://purl.uniprot.org/uniprot/A0A093H1E2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/118200:PEX5 ^@ http://purl.uniprot.org/uniprot/A0A093GIX2 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/118200:LOC104298461 ^@ http://purl.uniprot.org/uniprot/A0A093GG24 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:CCND1 ^@ http://purl.uniprot.org/uniprot/A0A093GE29 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/118200:DLD ^@ http://purl.uniprot.org/uniprot/A0A093G7E5 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond.|||acrosome|||flagellum http://togogenome.org/gene/118200:ITGB6 ^@ http://purl.uniprot.org/uniprot/A0A093FZQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:POLR3A ^@ http://purl.uniprot.org/uniprot/A0A093G4M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/118200:CEP76 ^@ http://purl.uniprot.org/uniprot/A0A093G6N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/118200:HEATR5B ^@ http://purl.uniprot.org/uniprot/A0A093GAR4 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/118200:DLL1 ^@ http://purl.uniprot.org/uniprot/A0A093IYM5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/118200:GJA8 ^@ http://purl.uniprot.org/uniprot/A0A093GII9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/118200:LOC104302123 ^@ http://purl.uniprot.org/uniprot/A0A093GQ77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/118200:BRINP1 ^@ http://purl.uniprot.org/uniprot/A0A093GQW3 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/118200:EPHA7 ^@ http://purl.uniprot.org/uniprot/A0A093FWZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:MIEF1 ^@ http://purl.uniprot.org/uniprot/A0A093IQA5 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/118200:BOK ^@ http://purl.uniprot.org/uniprot/A0A093IIL4 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/118200:CKMT2 ^@ http://purl.uniprot.org/uniprot/A0A093I8L4 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/118200:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A093GPA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:SEMA3C ^@ http://purl.uniprot.org/uniprot/A0A093FUN5 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:MRRF ^@ http://purl.uniprot.org/uniprot/A0A093J3A0 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/118200:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A093IPT7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/118200:METTL16 ^@ http://purl.uniprot.org/uniprot/A0A093GY17 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. http://togogenome.org/gene/118200:LOC104308718 ^@ http://purl.uniprot.org/uniprot/A0A093G6Q7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/118200:ENDOG ^@ http://purl.uniprot.org/uniprot/A0A093GBB8 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/118200:MDK ^@ http://purl.uniprot.org/uniprot/A0A093G466 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/118200:KCNE1 ^@ http://purl.uniprot.org/uniprot/A0A093H290 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the potassium channel KCNE family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:EIF2S1 ^@ http://purl.uniprot.org/uniprot/A0A093GDK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/118200:CNOT11 ^@ http://purl.uniprot.org/uniprot/A0A093G9Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/118200:KARS1 ^@ http://purl.uniprot.org/uniprot/A0A093JAH4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/118200:HOXD4 ^@ http://purl.uniprot.org/uniprot/A0A093GP83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/118200:ACTR10 ^@ http://purl.uniprot.org/uniprot/A0A093GWU6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/118200:APAF1 ^@ http://purl.uniprot.org/uniprot/A0A093H1R3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/118200:KCNE4 ^@ http://purl.uniprot.org/uniprot/A0A093GDZ1 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/118200:MEOX2 ^@ http://purl.uniprot.org/uniprot/A0A093GJ84 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:CLP1 ^@ http://purl.uniprot.org/uniprot/A0A093G7C8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:HMOX2 ^@ http://purl.uniprot.org/uniprot/A0A093GKW5 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/118200:IFRD1 ^@ http://purl.uniprot.org/uniprot/A0A093I5X4 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/118200:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/A0A093G3N5 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/118200:DSE ^@ http://purl.uniprot.org/uniprot/A0A093GDV7 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/118200:HMGB2 ^@ http://purl.uniprot.org/uniprot/A0A093GLE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/118200:KIF3B ^@ http://purl.uniprot.org/uniprot/A0A093GGQ1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/118200:B3GALT1 ^@ http://purl.uniprot.org/uniprot/A0A093IWN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/118200:OXSM ^@ http://purl.uniprot.org/uniprot/A0A093IWK6 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/118200:EDC3 ^@ http://purl.uniprot.org/uniprot/A0A093GA76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/118200:GRK7 ^@ http://purl.uniprot.org/uniprot/A0A093GET6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/118200:TADA2A ^@ http://purl.uniprot.org/uniprot/A0A093JA77 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:DCLRE1B ^@ http://purl.uniprot.org/uniprot/A0A093G1F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/118200:EIF5 ^@ http://purl.uniprot.org/uniprot/A0A093G5D7 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/118200:CFAP298 ^@ http://purl.uniprot.org/uniprot/A0A093GV08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/118200:EML6 ^@ http://purl.uniprot.org/uniprot/A0A093GE94 ^@ Function ^@ May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/118200:LOC104304256 ^@ http://purl.uniprot.org/uniprot/A0A093GUL4 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/118200:BMP7 ^@ http://purl.uniprot.org/uniprot/A0A093GGN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/118200:UTS2 ^@ http://purl.uniprot.org/uniprot/A0A093G9S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/118200:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A093GX44 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/118200:SLC25A15 ^@ http://purl.uniprot.org/uniprot/A0A093H112 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/118200:LOC104298441 ^@ http://purl.uniprot.org/uniprot/A0A093GG03 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:SMIM15 ^@ http://purl.uniprot.org/uniprot/A0A093G0H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/118200:NPSR1 ^@ http://purl.uniprot.org/uniprot/A0A093GJC5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/118200:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A093FYV5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/118200:SNRPA1 ^@ http://purl.uniprot.org/uniprot/A0A093GJG3 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/118200:KPNA2 ^@ http://purl.uniprot.org/uniprot/A0A093GQE6 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/118200:BROX ^@ http://purl.uniprot.org/uniprot/A0A093GM71 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/118200:NGLY1 ^@ http://purl.uniprot.org/uniprot/A0A093GVI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Cytoplasm|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. http://togogenome.org/gene/118200:GDAP2 ^@ http://purl.uniprot.org/uniprot/A0A093GK11 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/118200:JAGN1 ^@ http://purl.uniprot.org/uniprot/A0A093GXD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/118200:CLDN2 ^@ http://purl.uniprot.org/uniprot/A0A093J2B2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/118200:TBX2 ^@ http://purl.uniprot.org/uniprot/A0A093FYF0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/118200:NTF3 ^@ http://purl.uniprot.org/uniprot/A0A093J214 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/118200:CHCHD4 ^@ http://purl.uniprot.org/uniprot/A0A093FZU3 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/118200:OAT ^@ http://purl.uniprot.org/uniprot/A0A093FYB1 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/118200:SLC25A24 ^@ http://purl.uniprot.org/uniprot/A0A093GL09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/118200:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A093G6D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/118200:GDF9 ^@ http://purl.uniprot.org/uniprot/A0A093GP28 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/118200:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A093G6V6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/118200:LOC104298929 ^@ http://purl.uniprot.org/uniprot/A0A093G7V2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/118200:LOC104303207 ^@ http://purl.uniprot.org/uniprot/A0A093GHZ3 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/118200:RPLP1 ^@ http://purl.uniprot.org/uniprot/A0A093GFI5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/118200:LOC104310338 ^@ http://purl.uniprot.org/uniprot/A0A093IAZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/118200:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A093G7F6 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/118200:BPNT2 ^@ http://purl.uniprot.org/uniprot/A0A093ITQ3 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/118200:MRAP2 ^@ http://purl.uniprot.org/uniprot/A0A093GFP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/118200:RPL8 ^@ http://purl.uniprot.org/uniprot/A0A093FVK8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/118200:PRPF3 ^@ http://purl.uniprot.org/uniprot/A0A093J7P4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/118200:DHCR7 ^@ http://purl.uniprot.org/uniprot/A0A093GDQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/118200:NKX2-5 ^@ http://purl.uniprot.org/uniprot/A0A093GJS3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:LOC104300728 ^@ http://purl.uniprot.org/uniprot/A0A093GF02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/118200:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A093G474 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/118200:CLDN20 ^@ http://purl.uniprot.org/uniprot/A0A093J1P0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/118200:GLI2 ^@ http://purl.uniprot.org/uniprot/A0A093G9H4 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/118200:FAM163A ^@ http://purl.uniprot.org/uniprot/A0A093GGV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/118200:CDX1 ^@ http://purl.uniprot.org/uniprot/A0A093G3H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/118200:VEPH1 ^@ http://purl.uniprot.org/uniprot/A0A093G6V7 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/118200:CRH ^@ http://purl.uniprot.org/uniprot/A0A093ITN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/118200:SLC35B1 ^@ http://purl.uniprot.org/uniprot/A0A093GJC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/118200:MMP23B ^@ http://purl.uniprot.org/uniprot/A0A093GPW0 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:CBR1 ^@ http://purl.uniprot.org/uniprot/A0A093IXB0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/118200:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A093GBX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/118200:GLYR1 ^@ http://purl.uniprot.org/uniprot/A0A093IL13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/118200:LOC104309108 ^@ http://purl.uniprot.org/uniprot/A0A093G193 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/118200:PVALB ^@ http://purl.uniprot.org/uniprot/A0A093GPJ2 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/118200:BMP5 ^@ http://purl.uniprot.org/uniprot/A0A093GAJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/118200:MRPS17 ^@ http://purl.uniprot.org/uniprot/A0A093GR18 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/118200:CCDC126 ^@ http://purl.uniprot.org/uniprot/A0A093GYN0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/118200:LPAR4 ^@ http://purl.uniprot.org/uniprot/A0A093GCS2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/118200:LOC104306797 ^@ http://purl.uniprot.org/uniprot/A0A093GUU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:LOC104298004 ^@ http://purl.uniprot.org/uniprot/A0A093G8E0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/118200:EIF2B2 ^@ http://purl.uniprot.org/uniprot/A0A093H5K7 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/118200:MAS1 ^@ http://purl.uniprot.org/uniprot/A0A093H818 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/118200:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A093G3Z5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:PSMC6 ^@ http://purl.uniprot.org/uniprot/A0A093G8W5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/118200:STEEP1 ^@ http://purl.uniprot.org/uniprot/A0A093GD76 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/118200:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A093GKD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/118200:LOC104298452 ^@ http://purl.uniprot.org/uniprot/A0A093GG17 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:INTS12 ^@ http://purl.uniprot.org/uniprot/A0A093GEM1 ^@ Similarity ^@ Belongs to the Integrator subunit 12 family. http://togogenome.org/gene/118200:CNOT8 ^@ http://purl.uniprot.org/uniprot/A0A093GUG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/118200:DDO ^@ http://purl.uniprot.org/uniprot/A0A093GBX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/118200:GATA3 ^@ http://purl.uniprot.org/uniprot/A0A093GKB3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:SLC25A48 ^@ http://purl.uniprot.org/uniprot/A0A093FWT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/118200:TCEANC ^@ http://purl.uniprot.org/uniprot/A0A093GCP0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:MBTD1 ^@ http://purl.uniprot.org/uniprot/A0A093G0H7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:MIS12 ^@ http://purl.uniprot.org/uniprot/A0A093G5N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mis12 family.|||kinetochore http://togogenome.org/gene/118200:LOC104302220 ^@ http://purl.uniprot.org/uniprot/A0A093GIH8 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/118200:BIRC2 ^@ http://purl.uniprot.org/uniprot/A0A093GLN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/118200:ARRDC3 ^@ http://purl.uniprot.org/uniprot/A0A093GVW6 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/118200:MYCL ^@ http://purl.uniprot.org/uniprot/A0A093H0A5 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/118200:LOC104300056 ^@ http://purl.uniprot.org/uniprot/A0A093IKA2 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/118200:PNN ^@ http://purl.uniprot.org/uniprot/A0A093GRS8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/118200:CD9 ^@ http://purl.uniprot.org/uniprot/A0A093GRU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/118200:ARK2N ^@ http://purl.uniprot.org/uniprot/A0A093GNG5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:SF3B5 ^@ http://purl.uniprot.org/uniprot/A0A093H952 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/118200:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A093H4W3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/118200:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/A0A093GZU2 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/118200:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A093GW05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/118200:LSM8 ^@ http://purl.uniprot.org/uniprot/A0A093G801 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/118200:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A093GPG9 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/118200:EXO1 ^@ http://purl.uniprot.org/uniprot/A0A093HAT1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/118200:RNF182 ^@ http://purl.uniprot.org/uniprot/A0A093FZ64 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/118200:MED13 ^@ http://purl.uniprot.org/uniprot/A0A093FVB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/118200:CHRNA9 ^@ http://purl.uniprot.org/uniprot/A0A093I8R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/118200:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/A0A093G9M1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/118200:DLX6 ^@ http://purl.uniprot.org/uniprot/A0A093GKR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:CDKL1 ^@ http://purl.uniprot.org/uniprot/A0A093GBR7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/118200:LOC104296805 ^@ http://purl.uniprot.org/uniprot/A0A093I3R4 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/118200:HSPA14 ^@ http://purl.uniprot.org/uniprot/A0A093GJW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||cytosol http://togogenome.org/gene/118200:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/A0A093IUS7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/118200:SOX14 ^@ http://purl.uniprot.org/uniprot/A0A093GCB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:LOC104306854 ^@ http://purl.uniprot.org/uniprot/A0A093G633 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/118200:HSPB3 ^@ http://purl.uniprot.org/uniprot/A0A093GVI0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/118200:TMEM50B ^@ http://purl.uniprot.org/uniprot/A0A093J2L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/118200:MAB21L1 ^@ http://purl.uniprot.org/uniprot/A0A093GFU1 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/118200:PSMD12 ^@ http://purl.uniprot.org/uniprot/A0A093GIF9 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/118200:LOC104300139 ^@ http://purl.uniprot.org/uniprot/A0A093GK53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/118200:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/A0A093J6W3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/118200:GNG12 ^@ http://purl.uniprot.org/uniprot/A0A093JBY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/118200:SLC13A4 ^@ http://purl.uniprot.org/uniprot/A0A093GJ34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/118200:LOC104303534 ^@ http://purl.uniprot.org/uniprot/A0A093GTI3 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/118200:FGFBP2 ^@ http://purl.uniprot.org/uniprot/A0A093G7Z1 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/118200:GNPTAB ^@ http://purl.uniprot.org/uniprot/A0A093IBU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stealth family.|||Membrane http://togogenome.org/gene/118200:NID1 ^@ http://purl.uniprot.org/uniprot/A0A093G316 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/118200:VPS33A ^@ http://purl.uniprot.org/uniprot/A0A093HEA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/118200:SLC5A3 ^@ http://purl.uniprot.org/uniprot/A0A093H297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/118200:LOC104299999 ^@ http://purl.uniprot.org/uniprot/A0A093GAE9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/118200:CIAO2A ^@ http://purl.uniprot.org/uniprot/A0A093GS61 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/118200:GPX7 ^@ http://purl.uniprot.org/uniprot/A0A093GW48 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/118200:GUCY2C ^@ http://purl.uniprot.org/uniprot/A0A093GHZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/118200:NIPAL3 ^@ http://purl.uniprot.org/uniprot/A0A093J831 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/118200:B3GALT2 ^@ http://purl.uniprot.org/uniprot/A0A093FWH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/118200:RRH ^@ http://purl.uniprot.org/uniprot/A0A093GUD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/118200:KLHL15 ^@ http://purl.uniprot.org/uniprot/A0A093GKQ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:LOC104298456 ^@ http://purl.uniprot.org/uniprot/A0A093GGD0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:COPS8 ^@ http://purl.uniprot.org/uniprot/A0A093ILK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/118200:CPLX3 ^@ http://purl.uniprot.org/uniprot/A0A093G0P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/118200:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A093G2N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/118200:OLAH ^@ http://purl.uniprot.org/uniprot/A0A093J6A3 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/118200:PRKAB2 ^@ http://purl.uniprot.org/uniprot/A0A093IFR0 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/118200:LOC104298447 ^@ http://purl.uniprot.org/uniprot/A0A093GGD0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:TIMM9 ^@ http://purl.uniprot.org/uniprot/A0A093H5R7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/118200:LOC104296486 ^@ http://purl.uniprot.org/uniprot/A0A093GBI7 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/118200:CMC2 ^@ http://purl.uniprot.org/uniprot/A0A093GLK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/118200:INS ^@ http://purl.uniprot.org/uniprot/A0A093GS49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/118200:ADA2 ^@ http://purl.uniprot.org/uniprot/A0A093GVJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/118200:LOC104298451 ^@ http://purl.uniprot.org/uniprot/A0A093G9N1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:NIM1K ^@ http://purl.uniprot.org/uniprot/A0A093GBH2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/118200:NUDT12 ^@ http://purl.uniprot.org/uniprot/A0A093GSX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/118200:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A093JDF4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/118200:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A093I352 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:LOC104297701 ^@ http://purl.uniprot.org/uniprot/A0A093GE53 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/118200:C2H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A093GTI1 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/118200:CEP55 ^@ http://purl.uniprot.org/uniprot/A0A093IET2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/118200:LOC104298454 ^@ http://purl.uniprot.org/uniprot/A0A093GGD0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:PDK4 ^@ http://purl.uniprot.org/uniprot/A0A093G613 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/118200:KIF20A ^@ http://purl.uniprot.org/uniprot/A0A093GTZ7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/118200:BDKRB2 ^@ http://purl.uniprot.org/uniprot/A0A093J5J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/118200:DDX59 ^@ http://purl.uniprot.org/uniprot/A0A093GEN0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/118200:DPH3 ^@ http://purl.uniprot.org/uniprot/A0A093GB72 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/118200:LOC104304958 ^@ http://purl.uniprot.org/uniprot/A0A093IXE5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/118200:WARS2 ^@ http://purl.uniprot.org/uniprot/A0A093GRA4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/118200:MRPL41 ^@ http://purl.uniprot.org/uniprot/A0A093GCN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/118200:PCK1 ^@ http://purl.uniprot.org/uniprot/A0A093IRR9 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/118200:RIOX1 ^@ http://purl.uniprot.org/uniprot/A0A093GB83 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. http://togogenome.org/gene/118200:EHF ^@ http://purl.uniprot.org/uniprot/A0A093GGH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/118200:UBA5 ^@ http://purl.uniprot.org/uniprot/A0A093GFX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Golgi apparatus http://togogenome.org/gene/118200:A1CF ^@ http://purl.uniprot.org/uniprot/A0A093GS87 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/118200:RPS2 ^@ http://purl.uniprot.org/uniprot/A0A093FTZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS5 family.|||Nucleus http://togogenome.org/gene/118200:MYF6 ^@ http://purl.uniprot.org/uniprot/A0A093GHW1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:DHDDS ^@ http://purl.uniprot.org/uniprot/A0A093GXV0 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/118200:SLC37A4 ^@ http://purl.uniprot.org/uniprot/A0A093H5Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/118200:CRHBP ^@ http://purl.uniprot.org/uniprot/A0A093G5Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/118200:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A093GSA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:HMGA2 ^@ http://purl.uniprot.org/uniprot/A0A093GMR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/118200:LACC1 ^@ http://purl.uniprot.org/uniprot/A0A093GVU2 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/118200:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A093GMD5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/118200:GPR12 ^@ http://purl.uniprot.org/uniprot/A0A093GTD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:SUB1 ^@ http://purl.uniprot.org/uniprot/A0A093GIR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Nucleus http://togogenome.org/gene/118200:EMP1 ^@ http://purl.uniprot.org/uniprot/A0A093GPX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/118200:POLR3H ^@ http://purl.uniprot.org/uniprot/A0A093IQ93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/118200:FKTN ^@ http://purl.uniprot.org/uniprot/A0A093GAP6 ^@ Similarity ^@ Belongs to the LicD transferase family. http://togogenome.org/gene/118200:CDC20 ^@ http://purl.uniprot.org/uniprot/A0A093GNV4 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/118200:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A093G7U8 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/118200:TEKT3 ^@ http://purl.uniprot.org/uniprot/A0A093FV64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/118200:EGR1 ^@ http://purl.uniprot.org/uniprot/A0A093GNZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/118200:IDH1 ^@ http://purl.uniprot.org/uniprot/A0A093IHV9 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/118200:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/A0A093GZ17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/118200:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A093H0L6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:LOC104298010 ^@ http://purl.uniprot.org/uniprot/A0A093I3X5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/118200:LOC104307388 ^@ http://purl.uniprot.org/uniprot/A0A093J827 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/118200:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A093IDV0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/118200:B3GALT6 ^@ http://purl.uniprot.org/uniprot/A0A093GPU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/118200:LOC104301748 ^@ http://purl.uniprot.org/uniprot/A0A093GNL8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/118200:DUSP16 ^@ http://purl.uniprot.org/uniprot/A0A093GNQ5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/118200:SEC61G ^@ http://purl.uniprot.org/uniprot/A0A093G606 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/118200:LONP2 ^@ http://purl.uniprot.org/uniprot/A0A093GPB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.|||Belongs to the peptidase S16 family.|||Nucleus|||Peroxisome matrix http://togogenome.org/gene/118200:SPRING1 ^@ http://purl.uniprot.org/uniprot/A0A093HDC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/118200:EEF1B2 ^@ http://purl.uniprot.org/uniprot/A0A093GH79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/118200:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A093G4U5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/118200:SULT1C4 ^@ http://purl.uniprot.org/uniprot/A0A093GA21 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/118200:MYOD1 ^@ http://purl.uniprot.org/uniprot/A0A093GKS0 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/118200:WT1 ^@ http://purl.uniprot.org/uniprot/A0A093G2G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/118200:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/A0A093GBE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/118200:RBP5 ^@ http://purl.uniprot.org/uniprot/A0A093IJ36 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/118200:SQLE ^@ http://purl.uniprot.org/uniprot/A0A093G874 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/118200:PSMA6 ^@ http://purl.uniprot.org/uniprot/A0A093GG46 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/118200:MCM5 ^@ http://purl.uniprot.org/uniprot/A0A093IQF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/118200:ATP23 ^@ http://purl.uniprot.org/uniprot/A0A093GHM3 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/118200:BLOC1S5 ^@ http://purl.uniprot.org/uniprot/A0A093G7D0 ^@ Function|||Similarity ^@ Belongs to the BLOC1S5 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). http://togogenome.org/gene/118200:RTCA ^@ http://purl.uniprot.org/uniprot/A0A093GW58 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/118200:MOS ^@ http://purl.uniprot.org/uniprot/A0A093ITQ8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/118200:HCRTR2 ^@ http://purl.uniprot.org/uniprot/A0A093IAN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:UFL1 ^@ http://purl.uniprot.org/uniprot/A0A093GFD9 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/118200:LOC104301575 ^@ http://purl.uniprot.org/uniprot/A0A093GNC2 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/118200:TMEM121 ^@ http://purl.uniprot.org/uniprot/A0A093IFP6 ^@ Similarity ^@ Belongs to the TMEM121 family. http://togogenome.org/gene/118200:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A093GYA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/118200:AQP1 ^@ http://purl.uniprot.org/uniprot/A0A093II09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/118200:LIPT1 ^@ http://purl.uniprot.org/uniprot/A0A093I7B8 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/118200:FSHB ^@ http://purl.uniprot.org/uniprot/A0A093GFN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/118200:MFN2 ^@ http://purl.uniprot.org/uniprot/A0A093IZX6 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/118200:UXS1 ^@ http://purl.uniprot.org/uniprot/A0A093G0D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/118200:LOC104303535 ^@ http://purl.uniprot.org/uniprot/A0A093GIN3 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/118200:TXNDC5 ^@ http://purl.uniprot.org/uniprot/A0A093FXL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/118200:LOC104297811 ^@ http://purl.uniprot.org/uniprot/A0A093GER6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:FARSB ^@ http://purl.uniprot.org/uniprot/A0A093G4L6 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/118200:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A093GL20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/118200:TMEM47 ^@ http://purl.uniprot.org/uniprot/A0A093G6S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/118200:LOC104297999 ^@ http://purl.uniprot.org/uniprot/A0A093FU83 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/118200:DDC ^@ http://purl.uniprot.org/uniprot/A0A093GNZ3 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/118200:TMEM35A ^@ http://purl.uniprot.org/uniprot/A0A093H236 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/118200:HSPA2 ^@ http://purl.uniprot.org/uniprot/A0A093G540 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/118200:MID1 ^@ http://purl.uniprot.org/uniprot/A0A093G699 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/118200:CASP2 ^@ http://purl.uniprot.org/uniprot/A0A093GIX8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/118200:TMEM129 ^@ http://purl.uniprot.org/uniprot/A0A093GLN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/118200:CENPN ^@ http://purl.uniprot.org/uniprot/A0A093IMC4 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/118200:ACTN2 ^@ http://purl.uniprot.org/uniprot/A0A093FTA5 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/118200:RTF2 ^@ http://purl.uniprot.org/uniprot/A0A093GQV8 ^@ Similarity ^@ Belongs to the rtf2 family. http://togogenome.org/gene/118200:CAT ^@ http://purl.uniprot.org/uniprot/A0A093GVS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/118200:SLC26A9 ^@ http://purl.uniprot.org/uniprot/A0A093GPD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.|||Membrane http://togogenome.org/gene/118200:CLCN4 ^@ http://purl.uniprot.org/uniprot/A0A093IT59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/118200:HIGD1A ^@ http://purl.uniprot.org/uniprot/A0A093G8N3 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/118200:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/A0A093GLG2 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/118200:LOC104298439 ^@ http://purl.uniprot.org/uniprot/A0A093GGD0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A093GH86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/118200:CER1 ^@ http://purl.uniprot.org/uniprot/A0A093GJK1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/118200:ZNF330 ^@ http://purl.uniprot.org/uniprot/A0A093GC59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||nucleolus http://togogenome.org/gene/118200:DLX5 ^@ http://purl.uniprot.org/uniprot/A0A093GS46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/118200:PIGF ^@ http://purl.uniprot.org/uniprot/A0A093I8G0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/118200:RPS3A ^@ http://purl.uniprot.org/uniprot/A0A093FUA5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).|||Cytoplasm|||nucleolus http://togogenome.org/gene/118200:GPHB5 ^@ http://purl.uniprot.org/uniprot/A0A093FYK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/118200:GYS2 ^@ http://purl.uniprot.org/uniprot/A0A093GIS8 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/118200:SLC51A ^@ http://purl.uniprot.org/uniprot/A0A093GS33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:GREM2 ^@ http://purl.uniprot.org/uniprot/A0A093H1T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/118200:LOC104299264 ^@ http://purl.uniprot.org/uniprot/A0A093GHV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/118200:VPS54 ^@ http://purl.uniprot.org/uniprot/A0A093I4P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/118200:AMZ1 ^@ http://purl.uniprot.org/uniprot/A0A093G3S4 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/118200:CTLA4 ^@ http://purl.uniprot.org/uniprot/A0A093IHU8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/118200:TYMS ^@ http://purl.uniprot.org/uniprot/A0A093ITI5 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/118200:POSTN ^@ http://purl.uniprot.org/uniprot/A0A093GFT1 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/118200:PTER ^@ http://purl.uniprot.org/uniprot/A0A093GY44 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:LOC104298446 ^@ http://purl.uniprot.org/uniprot/A0A093IGK5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:UNC50 ^@ http://purl.uniprot.org/uniprot/A0A093GR77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/118200:DPT ^@ http://purl.uniprot.org/uniprot/A0A093FWD7 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/118200:TMCC1 ^@ http://purl.uniprot.org/uniprot/A0A093GIG4 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/118200:KCNMB1 ^@ http://purl.uniprot.org/uniprot/A0A093G856 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:KXD1 ^@ http://purl.uniprot.org/uniprot/A0A093IM97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/118200:CALHM2 ^@ http://purl.uniprot.org/uniprot/A0A093GZ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/118200:LOC104298455 ^@ http://purl.uniprot.org/uniprot/A0A093IGL9 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/118200:SNX20 ^@ http://purl.uniprot.org/uniprot/A0A093GKL0 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Membrane http://togogenome.org/gene/118200:GMPR ^@ http://purl.uniprot.org/uniprot/A0A093GEX8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/118200:BCL2A1 ^@ http://purl.uniprot.org/uniprot/A0A093GI82 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/118200:EIPR1 ^@ http://purl.uniprot.org/uniprot/A0A093GEA9 ^@ Similarity ^@ Belongs to the WD repeat EIPR1 family. http://togogenome.org/gene/118200:CNOT7 ^@ http://purl.uniprot.org/uniprot/A0A093IVD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/118200:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A093GA25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/118200:CORT ^@ http://purl.uniprot.org/uniprot/A0A093GPP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/118200:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A093GEJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/118200:TMCO3 ^@ http://purl.uniprot.org/uniprot/A0A093IGY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:POLR3F ^@ http://purl.uniprot.org/uniprot/A0A093I5P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/118200:LOC104309197 ^@ http://purl.uniprot.org/uniprot/A0A093FYE5 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/118200:GPR146 ^@ http://purl.uniprot.org/uniprot/A0A093I6C7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/118200:HSP90AA1 ^@ http://purl.uniprot.org/uniprot/A0A093G5E8 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/118200:PTH ^@ http://purl.uniprot.org/uniprot/A0A093GC38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.|||Secreted http://togogenome.org/gene/118200:KDELR3 ^@ http://purl.uniprot.org/uniprot/A0A093IQB5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/118200:OTC ^@ http://purl.uniprot.org/uniprot/A0A093G587 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/118200:LOC104300135 ^@ http://purl.uniprot.org/uniprot/A0A093GDS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:LOC104302538 ^@ http://purl.uniprot.org/uniprot/A0A093GJ77 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/118200:PTX3 ^@ http://purl.uniprot.org/uniprot/A0A093G0D8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:TFRC ^@ http://purl.uniprot.org/uniprot/A0A093GH73 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/118200:PDE6G ^@ http://purl.uniprot.org/uniprot/A0A093GEL6 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/118200:MKX ^@ http://purl.uniprot.org/uniprot/A0A093IGP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:DMBX1 ^@ http://purl.uniprot.org/uniprot/A0A093IP89 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:LOC104306344 ^@ http://purl.uniprot.org/uniprot/A0A093H204 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:TRAF5 ^@ http://purl.uniprot.org/uniprot/A0A093GDS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/118200:TBC1D7 ^@ http://purl.uniprot.org/uniprot/A0A093GFB0 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/118200:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A093GSL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/118200:DCTN4 ^@ http://purl.uniprot.org/uniprot/A0A093I3K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/118200:ARSI ^@ http://purl.uniprot.org/uniprot/A0A093FX18 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/118200:NIP7 ^@ http://purl.uniprot.org/uniprot/A0A093IUJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/118200:HOXA6 ^@ http://purl.uniprot.org/uniprot/A0A093H7P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/118200:PEX1 ^@ http://purl.uniprot.org/uniprot/A0A093J689 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||cytosol http://togogenome.org/gene/118200:FIGNL1 ^@ http://purl.uniprot.org/uniprot/A0A093IZ69 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/118200:SLC35E2B ^@ http://purl.uniprot.org/uniprot/A0A093J084 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:ADSL ^@ http://purl.uniprot.org/uniprot/A0A093GF74 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/118200:LOC104299271 ^@ http://purl.uniprot.org/uniprot/A0A093FUM0 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/118200:IP6K2 ^@ http://purl.uniprot.org/uniprot/A0A093G731 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/118200:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A093GFJ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/118200:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A093GNW4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A093G7Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/118200:SNRPD3 ^@ http://purl.uniprot.org/uniprot/A0A093I9D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/118200:CRMP1 ^@ http://purl.uniprot.org/uniprot/A0A093GLL1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/118200:LOC104298460 ^@ http://purl.uniprot.org/uniprot/A0A093IGK8 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A093G6X0 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/118200:TFAP2D ^@ http://purl.uniprot.org/uniprot/A0A093GV48 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/118200:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A093IL82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/118200:UBA3 ^@ http://purl.uniprot.org/uniprot/A0A093FZV7 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/118200:CYGB ^@ http://purl.uniprot.org/uniprot/A0A093GET0 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/118200:ALKAL2 ^@ http://purl.uniprot.org/uniprot/A0A093IZ84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/118200:NUDT3 ^@ http://purl.uniprot.org/uniprot/A0A093GN00 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/118200:RFLNA ^@ http://purl.uniprot.org/uniprot/A0A093HCX2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/118200:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A093G978 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/118200:FOXJ1 ^@ http://purl.uniprot.org/uniprot/A0A093G5F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FOXJ1 family.|||Nucleus http://togogenome.org/gene/118200:INHBA ^@ http://purl.uniprot.org/uniprot/A0A093GU41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/118200:MAB21L2 ^@ http://purl.uniprot.org/uniprot/A0A093G6E2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/118200:C1GALT1 ^@ http://purl.uniprot.org/uniprot/A0A093GS43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:KDSR ^@ http://purl.uniprot.org/uniprot/A0A093GUJ0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/118200:SOX11 ^@ http://purl.uniprot.org/uniprot/A0A093IGV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:PRPSAP1 ^@ http://purl.uniprot.org/uniprot/A0A093IFB3 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/118200:KLHL40 ^@ http://purl.uniprot.org/uniprot/A0A093GFE5 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/118200:SLC2A9 ^@ http://purl.uniprot.org/uniprot/A0A093GIP1 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/118200:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/A0A093GZL9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/118200:SNRPG ^@ http://purl.uniprot.org/uniprot/A0A093G0L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/118200:TRPC5 ^@ http://purl.uniprot.org/uniprot/A0A093GKM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/A0A093GA09 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/118200:MMP2 ^@ http://purl.uniprot.org/uniprot/A0A093GB28 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/118200:FAM83B ^@ http://purl.uniprot.org/uniprot/A0A093G0T7 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/118200:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A093G2J6 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/118200:LOC104309109 ^@ http://purl.uniprot.org/uniprot/A0A093G7W0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/118200:CALHM1 ^@ http://purl.uniprot.org/uniprot/A0A093H6L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/118200:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A093IC35 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||cytoskeleton http://togogenome.org/gene/118200:SLC7A13 ^@ http://purl.uniprot.org/uniprot/A0A093G7W9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:MED30 ^@ http://purl.uniprot.org/uniprot/A0A093GD72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/118200:SPCS1 ^@ http://purl.uniprot.org/uniprot/A0A093GL68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/118200:WDR48 ^@ http://purl.uniprot.org/uniprot/A0A093GPX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/118200:RSPO1 ^@ http://purl.uniprot.org/uniprot/A0A093GXI0 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/118200:B3GNT2 ^@ http://purl.uniprot.org/uniprot/A0A093I4P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/118200:LOC104298784 ^@ http://purl.uniprot.org/uniprot/A0A093IHB2 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/118200:INTS10 ^@ http://purl.uniprot.org/uniprot/A0A093GN32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/118200:CRYAA ^@ http://purl.uniprot.org/uniprot/A0A093GPY0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/118200:HOXA3 ^@ http://purl.uniprot.org/uniprot/A0A093GYN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/118200:EIF4A2 ^@ http://purl.uniprot.org/uniprot/A0A093GK82 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/118200:INTS2 ^@ http://purl.uniprot.org/uniprot/A0A093I512 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/118200:ORMDL1 ^@ http://purl.uniprot.org/uniprot/A0A093G2Z1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/118200:LOC104299307 ^@ http://purl.uniprot.org/uniprot/A0A093G8P2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/118200:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A093GEZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/118200:PAQR8 ^@ http://purl.uniprot.org/uniprot/A0A093GHG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/118200:LOC104303526 ^@ http://purl.uniprot.org/uniprot/A0A093G582 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:CITED4 ^@ http://purl.uniprot.org/uniprot/A0A093IA60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/118200:LOC104308965 ^@ http://purl.uniprot.org/uniprot/A0A093G7H8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/118200:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A093FYZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/118200:COPB1 ^@ http://purl.uniprot.org/uniprot/A0A093GNI7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/118200:GATA2 ^@ http://purl.uniprot.org/uniprot/A0A093G740 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:LOC104297491 ^@ http://purl.uniprot.org/uniprot/A0A093G498 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:CCK ^@ http://purl.uniprot.org/uniprot/A0A093G681 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/118200:PHF5A ^@ http://purl.uniprot.org/uniprot/A0A093GI20 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/118200:LOC104298448 ^@ http://purl.uniprot.org/uniprot/A0A093GGE4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A093IU24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/118200:UNC93A ^@ http://purl.uniprot.org/uniprot/A0A093GNC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/118200:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A093G6B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/118200:ASIC4 ^@ http://purl.uniprot.org/uniprot/A0A093G2S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/118200:ACSL5 ^@ http://purl.uniprot.org/uniprot/A0A093H5K1 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/118200:MLH1 ^@ http://purl.uniprot.org/uniprot/A0A093GK37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/118200:PSMG2 ^@ http://purl.uniprot.org/uniprot/A0A093I6V6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/118200:BRS3 ^@ http://purl.uniprot.org/uniprot/A0A093GLR3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/118200:ACAD11 ^@ http://purl.uniprot.org/uniprot/A0A093GFI9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/118200:ALAS1 ^@ http://purl.uniprot.org/uniprot/A0A093GY77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/118200:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A093GRD6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/118200:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A093GB14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/118200:PIGW ^@ http://purl.uniprot.org/uniprot/A0A093GZR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/118200:NANOG ^@ http://purl.uniprot.org/uniprot/A0A093GCB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:IRF4 ^@ http://purl.uniprot.org/uniprot/A0A093GS73 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:LOC104298449 ^@ http://purl.uniprot.org/uniprot/A0A093G9N1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:APOD ^@ http://purl.uniprot.org/uniprot/A0A093GYS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/118200:FGF9 ^@ http://purl.uniprot.org/uniprot/A0A093GT51 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/118200:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A093G6Q6 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/118200:ITGA9 ^@ http://purl.uniprot.org/uniprot/A0A093GJX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/118200:COG2 ^@ http://purl.uniprot.org/uniprot/A0A093GY98 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/118200:SULF1 ^@ http://purl.uniprot.org/uniprot/A0A093GLD7 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/118200:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A093FYM2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/118200:GPLD1 ^@ http://purl.uniprot.org/uniprot/A0A093GFV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/118200:LOC104302537 ^@ http://purl.uniprot.org/uniprot/A0A093GGB9 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/118200:C4H7orf25 ^@ http://purl.uniprot.org/uniprot/A0A093GUR8 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/118200:LEO1 ^@ http://purl.uniprot.org/uniprot/A0A093IDT6 ^@ Similarity ^@ Belongs to the LEO1 family. http://togogenome.org/gene/118200:NDUFB1 ^@ http://purl.uniprot.org/uniprot/A0A093GMW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/118200:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A093GNU0 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/118200:OGDHL ^@ http://purl.uniprot.org/uniprot/A0A093GMU7 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/118200:KCNK1 ^@ http://purl.uniprot.org/uniprot/A0A093FTC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/118200:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A093G5Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/118200:HADH ^@ http://purl.uniprot.org/uniprot/A0A093GEK8 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/118200:ALDOB ^@ http://purl.uniprot.org/uniprot/A0A093GVT4 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/118200:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A093GBB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/118200:CDKN1B ^@ http://purl.uniprot.org/uniprot/A0A093GV74 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/118200:RUVBL1 ^@ http://purl.uniprot.org/uniprot/A0A093G701 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/118200:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A093GD13 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:LOC104297746 ^@ http://purl.uniprot.org/uniprot/A0A093G7Y0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/118200:KIN ^@ http://purl.uniprot.org/uniprot/A0A093IKD8 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/118200:FABP7 ^@ http://purl.uniprot.org/uniprot/A0A093HDX5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/118200:DNAAF4 ^@ http://purl.uniprot.org/uniprot/A0A093G9E2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Dynein axonemal particle|||neuron projection http://togogenome.org/gene/118200:TRH ^@ http://purl.uniprot.org/uniprot/A0A093ITK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.|||Secreted http://togogenome.org/gene/118200:IRF8 ^@ http://purl.uniprot.org/uniprot/A0A093IUM9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:HOXB9 ^@ http://purl.uniprot.org/uniprot/A0A093GJH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/118200:BTG4 ^@ http://purl.uniprot.org/uniprot/A0A093I2V6 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/118200:EARS2 ^@ http://purl.uniprot.org/uniprot/A0A093H4H1 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/118200:LOC104303159 ^@ http://purl.uniprot.org/uniprot/A0A093G527 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:CPSF2 ^@ http://purl.uniprot.org/uniprot/A0A093GU84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/118200:MTHFD1 ^@ http://purl.uniprot.org/uniprot/A0A093FYK4 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/118200:DNAL4 ^@ http://purl.uniprot.org/uniprot/A0A093GI43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/118200:MC4R ^@ http://purl.uniprot.org/uniprot/A0A093GEI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/118200:ACTC1 ^@ http://purl.uniprot.org/uniprot/A0A093GAQ1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/118200:GNB3 ^@ http://purl.uniprot.org/uniprot/A0A093GIV6 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/118200:ID2 ^@ http://purl.uniprot.org/uniprot/A0A093ITI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:NDUFB9 ^@ http://purl.uniprot.org/uniprot/A0A093G8E1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/118200:RGS9BP ^@ http://purl.uniprot.org/uniprot/A0A093GPU9 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/118200:CD36 ^@ http://purl.uniprot.org/uniprot/A0A093I4C0 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/118200:ABCD2 ^@ http://purl.uniprot.org/uniprot/A0A093I7G2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:TLL1 ^@ http://purl.uniprot.org/uniprot/A0A093GJI3 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:LOC104308964 ^@ http://purl.uniprot.org/uniprot/A0A093G0T3 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/118200:TPM4 ^@ http://purl.uniprot.org/uniprot/A0A093FXY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/118200:LOC104300827 ^@ http://purl.uniprot.org/uniprot/A0A093GM47 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/118200:FTCD ^@ http://purl.uniprot.org/uniprot/A0A093GKQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds and promotes bundling of vimentin filaments originating from the Golgi.|||Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.|||Golgi apparatus|||Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.|||In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.|||In the N-terminal section; belongs to the formiminotransferase family.|||centriole http://togogenome.org/gene/118200:HSPA4L ^@ http://purl.uniprot.org/uniprot/A0A093GAW8 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/118200:LOC104309716 ^@ http://purl.uniprot.org/uniprot/A0A093G9C5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/118200:CKS2 ^@ http://purl.uniprot.org/uniprot/A0A093IN06 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/118200:MAT1A ^@ http://purl.uniprot.org/uniprot/A0A093G6A9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/118200:MGAT2 ^@ http://purl.uniprot.org/uniprot/A0A093GI23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/118200:C7H2orf49 ^@ http://purl.uniprot.org/uniprot/A0A093IA39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/118200:LOC104310186 ^@ http://purl.uniprot.org/uniprot/A0A093G0P9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/118200:RAD1 ^@ http://purl.uniprot.org/uniprot/A0A093FYM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/118200:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A093GIA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/118200:TPI1 ^@ http://purl.uniprot.org/uniprot/A0A093IJ22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/118200:MNAT1 ^@ http://purl.uniprot.org/uniprot/A0A093FVH6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/118200:AASS ^@ http://purl.uniprot.org/uniprot/A0A093GKI4 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/118200:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A093G025 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/118200:RIOK2 ^@ http://purl.uniprot.org/uniprot/A0A093IFU2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/118200:LOC104303537 ^@ http://purl.uniprot.org/uniprot/A0A093GST7 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/118200:TMX2 ^@ http://purl.uniprot.org/uniprot/A0A093G4C3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/118200:DERL1 ^@ http://purl.uniprot.org/uniprot/A0A093GPW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/118200:EFEMP1 ^@ http://purl.uniprot.org/uniprot/A0A093GH42 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:LOC104303479 ^@ http://purl.uniprot.org/uniprot/A0A093GLG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/118200:EDNRA ^@ http://purl.uniprot.org/uniprot/A0A093G5X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/118200:LOC104309715 ^@ http://purl.uniprot.org/uniprot/A0A093G2Q9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/118200:GDF5 ^@ http://purl.uniprot.org/uniprot/A0A093IX97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/118200:GTF2E1 ^@ http://purl.uniprot.org/uniprot/A0A093GNX0 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/118200:TH ^@ http://purl.uniprot.org/uniprot/A0A093GZE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region http://togogenome.org/gene/118200:JUN ^@ http://purl.uniprot.org/uniprot/A0A093IPH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/118200:PITX3 ^@ http://purl.uniprot.org/uniprot/A0A093IEJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/118200:SNX33 ^@ http://purl.uniprot.org/uniprot/A0A093GT92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/118200:EVX1 ^@ http://purl.uniprot.org/uniprot/A0A093H8U0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:MYMK ^@ http://purl.uniprot.org/uniprot/A0A093G4U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:CCNK ^@ http://purl.uniprot.org/uniprot/A0A093G5G7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/118200:MALL ^@ http://purl.uniprot.org/uniprot/A0A093GH56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:MOGAT2 ^@ http://purl.uniprot.org/uniprot/A0A093GQ57 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/118200:RNF20 ^@ http://purl.uniprot.org/uniprot/A0A093GWP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE1 family.|||Nucleus http://togogenome.org/gene/118200:CPB1 ^@ http://purl.uniprot.org/uniprot/A0A093G3B9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/118200:LOC104296378 ^@ http://purl.uniprot.org/uniprot/A0A093GB99 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/118200:SLC35C1 ^@ http://purl.uniprot.org/uniprot/A0A093GKY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:MB ^@ http://purl.uniprot.org/uniprot/A0A093GQ63 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/118200:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A093GSB0 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/118200:ST8SIA4 ^@ http://purl.uniprot.org/uniprot/A0A093GLY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/118200:NMUR2 ^@ http://purl.uniprot.org/uniprot/A0A093G387 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/118200:YBEY ^@ http://purl.uniprot.org/uniprot/A0A093IKW5 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/118200:FUT10 ^@ http://purl.uniprot.org/uniprot/A0A093H7U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Probable fucosyltransferase. http://togogenome.org/gene/118200:LOC104297684 ^@ http://purl.uniprot.org/uniprot/A0A093IEJ0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/118200:PRPH2 ^@ http://purl.uniprot.org/uniprot/A0A093GC74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/118200:CCDC47 ^@ http://purl.uniprot.org/uniprot/A0A093G1H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/118200:CCZ1 ^@ http://purl.uniprot.org/uniprot/A0A093G479 ^@ Similarity ^@ Belongs to the CCZ1 family. http://togogenome.org/gene/118200:C10H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A093GMV3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/118200:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A093GCY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/118200:TADA3 ^@ http://purl.uniprot.org/uniprot/A0A093GMC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/118200:F13A1 ^@ http://purl.uniprot.org/uniprot/A0A093IDP8 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/118200:APRT ^@ http://purl.uniprot.org/uniprot/A0A093IUL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/118200:PLA2G1B ^@ http://purl.uniprot.org/uniprot/A0A093H6X4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/118200:RPS3 ^@ http://purl.uniprot.org/uniprot/A0A093IR26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||spindle http://togogenome.org/gene/118200:CDPF1 ^@ http://purl.uniprot.org/uniprot/A0A093H173 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/118200:LOC104297321 ^@ http://purl.uniprot.org/uniprot/A0A093GDC3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/118200:LOC104306988 ^@ http://purl.uniprot.org/uniprot/A0A093FZJ6 ^@ Function|||Similarity ^@ Belongs to the apovitellenin family.|||Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes. http://togogenome.org/gene/118200:GJA3 ^@ http://purl.uniprot.org/uniprot/A0A093GL79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/118200:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/A0A093GU91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/118200:CLDN14 ^@ http://purl.uniprot.org/uniprot/A0A093GPR7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/118200:SLC35E3 ^@ http://purl.uniprot.org/uniprot/A0A093IYV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:ANXA8L1 ^@ http://purl.uniprot.org/uniprot/A0A093G7S0 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/118200:PTPN14 ^@ http://purl.uniprot.org/uniprot/A0A093G4E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/118200:LOC104309008 ^@ http://purl.uniprot.org/uniprot/A0A093G7L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/118200:MFNG ^@ http://purl.uniprot.org/uniprot/A0A093GPI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/118200:GSTO1 ^@ http://purl.uniprot.org/uniprot/A0A093H6M5 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/118200:ZNF622 ^@ http://purl.uniprot.org/uniprot/A0A093H4G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/118200:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/A0A093H183 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Cytoplasm http://togogenome.org/gene/118200:CAMSAP2 ^@ http://purl.uniprot.org/uniprot/A0A093GBT4 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/118200:QTRT2 ^@ http://purl.uniprot.org/uniprot/A0A093G674 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/118200:C1H4orf47 ^@ http://purl.uniprot.org/uniprot/A0A093GHE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/118200:LOC104298443 ^@ http://purl.uniprot.org/uniprot/A0A093IGK2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A093IQF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/118200:BBS5 ^@ http://purl.uniprot.org/uniprot/A0A093GWF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS5 family.|||Membrane|||Required for ciliogenesis.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/118200:SMIM12 ^@ http://purl.uniprot.org/uniprot/A0A093GXK2 ^@ Similarity ^@ Belongs to the SMIM12 family. http://togogenome.org/gene/118200:CRYBB1 ^@ http://purl.uniprot.org/uniprot/A0A093H497 ^@ Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/118200:ASPA ^@ http://purl.uniprot.org/uniprot/A0A093IRX0 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/118200:RFTN2 ^@ http://purl.uniprot.org/uniprot/A0A093G825 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:LOC104298478 ^@ http://purl.uniprot.org/uniprot/A0A093G9N8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/118200:TMEM170B ^@ http://purl.uniprot.org/uniprot/A0A093GEW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/118200:CROT ^@ http://purl.uniprot.org/uniprot/A0A093GYK9 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/118200:EIF3E ^@ http://purl.uniprot.org/uniprot/A0A093GF41 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/118200:UCN3 ^@ http://purl.uniprot.org/uniprot/A0A093IKB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/118200:SLC16A9 ^@ http://purl.uniprot.org/uniprot/A0A093GMQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:HVCN1 ^@ http://purl.uniprot.org/uniprot/A0A093H6Q6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/118200:GRPR ^@ http://purl.uniprot.org/uniprot/A0A093IWS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/118200:GNL2 ^@ http://purl.uniprot.org/uniprot/A0A093J7T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/118200:RBM15B ^@ http://purl.uniprot.org/uniprot/A0A093IL98 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/118200:EMX2 ^@ http://purl.uniprot.org/uniprot/A0A093HDB3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/118200:FGB ^@ http://purl.uniprot.org/uniprot/A0A093G3Y9 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted