http://togogenome.org/gene/185431:Tb10.05.0190 ^@ http://purl.uniprot.org/uniprot/Q388Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.7.1510 ^@ http://purl.uniprot.org/uniprot/Q57WP9 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/185431:Tb927.4.3790 ^@ http://purl.uniprot.org/uniprot/Q583H3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/185431:TB927.1.4420 ^@ http://purl.uniprot.org/uniprot/Q4GYD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.70.0310 ^@ http://purl.uniprot.org/uniprot/Q38AV7 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/185431:Tb927.6.1770 ^@ http://purl.uniprot.org/uniprot/Q585N4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb09.211.3740 ^@ http://purl.uniprot.org/uniprot/Q38DD5 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/185431:Tb09.160.3540 ^@ http://purl.uniprot.org/uniprot/Q38F51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS1/PSF1 family.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.0510 ^@ http://purl.uniprot.org/uniprot/Q38AX4 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/185431:Tb927.6.4350 ^@ http://purl.uniprot.org/uniprot/Q587A1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/185431:Tb10.70.5110 ^@ http://purl.uniprot.org/uniprot/Q38BY9 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/185431:Tb927.7.3380 ^@ http://purl.uniprot.org/uniprot/Q57WF3 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/185431:Tb927.2.1800 ^@ http://purl.uniprot.org/uniprot/Q585S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/185431:Tb927.2.3370 ^@ http://purl.uniprot.org/uniprot/Q587E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb09.244.1600 ^@ http://purl.uniprot.org/uniprot/Q38CQ3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.5420 ^@ http://purl.uniprot.org/uniprot/Q580P5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.6325 ^@ http://purl.uniprot.org/uniprot/Q38C82 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/185431:Tb10.70.6210 ^@ http://purl.uniprot.org/uniprot/Q38C73 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. http://togogenome.org/gene/185431:Tb927.5.5080 ^@ http://purl.uniprot.org/uniprot/Q57UD8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.5480 ^@ http://purl.uniprot.org/uniprot/Q38C19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/185431:TB927.1.540 ^@ http://purl.uniprot.org/uniprot/Q4GZE8 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/185431:Tb927.6.1380 ^@ http://purl.uniprot.org/uniprot/Q585B1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.7.6080 ^@ http://purl.uniprot.org/uniprot/Q57VK3 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.6.1360 ^@ http://purl.uniprot.org/uniprot/Q585B1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.3.3340 ^@ http://purl.uniprot.org/uniprot/Q57V52 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/185431:Tb927.5.1550 ^@ http://purl.uniprot.org/uniprot/Q57VA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.3360 ^@ http://purl.uniprot.org/uniprot/Q38BK6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).|||Cytoplasm http://togogenome.org/gene/185431:Tb927.6.1390 ^@ http://purl.uniprot.org/uniprot/Q585A8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:TB927.1.2380 ^@ http://purl.uniprot.org/uniprot/Q4GYY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/185431:Tb927.8.5470 ^@ http://purl.uniprot.org/uniprot/Q57X35 ^@ Function|||Similarity ^@ Belongs to the calflagin family.|||May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form. http://togogenome.org/gene/185431:Tb927.2.5120 ^@ http://purl.uniprot.org/uniprot/Q585V8 ^@ Similarity ^@ Belongs to the synaptobrevin family. http://togogenome.org/gene/185431:Tb10.70.1540 ^@ http://purl.uniprot.org/uniprot/Q38B56 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/185431:TB927.1.2550 ^@ http://purl.uniprot.org/uniprot/Q4GYX7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/185431:Tb09.244.2740 ^@ http://purl.uniprot.org/uniprot/Q38CY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/185431:Tb10.406.0210 ^@ http://purl.uniprot.org/uniprot/Q389Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body http://togogenome.org/gene/185431:TB927.1.3110 ^@ http://purl.uniprot.org/uniprot/Q4GYR2 ^@ Similarity ^@ Belongs to the SNAP family. http://togogenome.org/gene/185431:Tb09.354.0180 ^@ http://purl.uniprot.org/uniprot/Q38G45 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.6k15.2450 ^@ http://purl.uniprot.org/uniprot/Q38AF6 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/185431:Tb927.7.2930 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.5.300 ^@ http://purl.uniprot.org/uniprot/Q57XH4 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:TB927.1.2360 ^@ http://purl.uniprot.org/uniprot/Q4GYY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/185431:Tb927.5.1810 ^@ http://purl.uniprot.org/uniprot/Q57ZQ0 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/185431:Tb927.2.4090 ^@ http://purl.uniprot.org/uniprot/Q586V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb10.389.0350 ^@ http://purl.uniprot.org/uniprot/Q388T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.8.2960 ^@ http://purl.uniprot.org/uniprot/Q57W77 ^@ Function|||Similarity ^@ Belongs to the BMT2 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/185431:Tb927.4.2380 ^@ http://purl.uniprot.org/uniprot/Q584E9 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/185431:Tb10.70.4070 ^@ http://purl.uniprot.org/uniprot/Q38BQ9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/185431:Tb10.70.3150 ^@ http://purl.uniprot.org/uniprot/Q38BI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.3.2440 ^@ http://purl.uniprot.org/uniprot/Q582V7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.8.920 ^@ http://purl.uniprot.org/uniprot/Q57YD9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/185431:Tb927.8.1330 ^@ http://purl.uniprot.org/uniprot/Q57VM1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/185431:Tb10.6k15.0960 ^@ http://purl.uniprot.org/uniprot/Q38A31 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/185431:Tb09.211.3050 ^@ http://purl.uniprot.org/uniprot/Q38DK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/185431:Tb10.389.0330 ^@ http://purl.uniprot.org/uniprot/Q388T4 ^@ Similarity ^@ Belongs to the UDPGP type 1 family. http://togogenome.org/gene/185431:Tb09.211.2360 ^@ http://purl.uniprot.org/uniprot/Q38DS1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb09.211.3280 ^@ http://purl.uniprot.org/uniprot/Q38DH8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/185431:Tb09.160.3730 ^@ http://purl.uniprot.org/uniprot/Q38F32 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb927.3.1500 ^@ http://purl.uniprot.org/uniprot/Q57XY3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.2480 ^@ http://purl.uniprot.org/uniprot/Q584D9 ^@ Similarity ^@ Belongs to the type-1 OGG1 family. http://togogenome.org/gene/185431:Tb927.6.1780 ^@ http://purl.uniprot.org/uniprot/Q585N3 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/185431:Tb927.3.1550 ^@ http://purl.uniprot.org/uniprot/Q57XY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.8.1720 ^@ http://purl.uniprot.org/uniprot/Q582B0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.8.5890 ^@ http://purl.uniprot.org/uniprot/Q57YJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/185431:Tb09.160.4690 ^@ http://purl.uniprot.org/uniprot/Q38ET7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/185431:TB927.1.1240 ^@ http://purl.uniprot.org/uniprot/Q4GZ95 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/185431:Tb927.6.480 ^@ http://purl.uniprot.org/uniprot/Q581F6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Major surface antigen of procyclic forms.|||Membrane http://togogenome.org/gene/185431:Tb927.8.7890 ^@ http://purl.uniprot.org/uniprot/Q57U55 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.6k15.3500 ^@ http://purl.uniprot.org/uniprot/Q38AP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/185431:Tb10.389.0140 ^@ http://purl.uniprot.org/uniprot/Q388R8 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/185431:Tb927.3.4890 ^@ http://purl.uniprot.org/uniprot/Q582P6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.|||Component of a multi-subunit COQ enzyme complex.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:TB927.1.2210 ^@ http://purl.uniprot.org/uniprot/Q4GZ00 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/185431:Tb927.7.210 ^@ http://purl.uniprot.org/uniprot/Q57U33 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/185431:Tb927.6.2340 ^@ http://purl.uniprot.org/uniprot/Q584S2 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/185431:Tb927.8.5090 ^@ http://purl.uniprot.org/uniprot/Q57UI1 ^@ Similarity ^@ Belongs to the RNA polymerase beta' chain family. http://togogenome.org/gene/185431:Tb09.354.0060 ^@ http://purl.uniprot.org/uniprot/Q38G47 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.6.4770 ^@ http://purl.uniprot.org/uniprot/Q587E3 ^@ Caution|||Developmental Stage|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although it belongs to the XPG/RAD2 endonuclease family, only two of the seven Asp residues involved in Mg(2+) binding are conserved suggesting that it has no nuclease activity.|||Belongs to the XPG/RAD2 endonuclease family.|||Expressed in the procyclic and bloodstream forms (at protein level).|||Forms a complex composed of at least MKT1, PBP1, XAC1 and LSM12 (PubMed:32532821). Within the complex, interacts (via C-terminus) with PBP1; the interaction is direct (PubMed:32532821, PubMed:24470144). Interacts with RNA-binding protein ZC3H11 (via MKT1-binding motif); the interaction is direct (PubMed:32532821, PubMed:24470144). May interact with RNA-binding proteins CFB1 and CFB2 (PubMed:32532821). Interacts with the EIF4E6-EIF4G5 translation initiation complex via EIF4G5; the interaction with EIF4G5 is direct (PubMed:32532821).|||Involved in post-transcriptional regulation of gene expression (PubMed:24470144). Promotes mRNA stabilization by recruiting a complex containing PBP1, LSM12 and XAC1 to mRNAs (PubMed:24470144, PubMed:32532821). Recruited to mRNAs by sequence-specific RNA binding proteins (PubMed:24470144). May regulate translation through interactions with the EIF4E6-EIF4G5 translation initiation complex (PubMed:32532821).|||RNAI-mediated knockdown in the bloodstream form is lethal (PubMed:24470144). RNAi-mediated knockdown in the procyclic form has no effect on viability (PubMed:24470144).|||Stress granule|||cytosol http://togogenome.org/gene/185431:Tb927.7.3560 ^@ http://purl.uniprot.org/uniprot/Q57WH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP44 family.|||Flagellar protein involved in flagellum axoneme organization and function.|||flagellum|||flagellum axoneme http://togogenome.org/gene/185431:Tb927.7.3780 ^@ http://purl.uniprot.org/uniprot/Q57WJ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/185431:Tb927.4.1440 ^@ http://purl.uniprot.org/uniprot/Q581T7 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/185431:Tb927.8.1200 ^@ http://purl.uniprot.org/uniprot/D6XMU9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/185431:Tb09.211.0620 ^@ http://purl.uniprot.org/uniprot/Q38E94 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/185431:Tb927.8.6030 ^@ http://purl.uniprot.org/uniprot/Q57YK4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/185431:Tb10.6k15.3350 ^@ http://purl.uniprot.org/uniprot/Q38AM9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/185431:Tb927.3.1450 ^@ http://purl.uniprot.org/uniprot/Q57XX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/185431:Tb927.3.4640 ^@ http://purl.uniprot.org/uniprot/Q582S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCC1 family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.3830 ^@ http://purl.uniprot.org/uniprot/Q581A3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/185431:Tb927.8.6830 ^@ http://purl.uniprot.org/uniprot/Q57TT0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.8.3220 ^@ http://purl.uniprot.org/uniprot/Q57YZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Nucleus http://togogenome.org/gene/185431:Tb927.7.2500 ^@ http://purl.uniprot.org/uniprot/D6XKG7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb927.4.5240 ^@ http://purl.uniprot.org/uniprot/Q584I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.6.1460 ^@ http://purl.uniprot.org/uniprot/Q585A1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/185431:Tb09.211.2150 ^@ http://purl.uniprot.org/uniprot/Q38DU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.6.4180 ^@ http://purl.uniprot.org/uniprot/Q586B6 ^@ Similarity ^@ Belongs to the FUN14 family. http://togogenome.org/gene/185431:Tb927.8.6640 ^@ http://purl.uniprot.org/uniprot/Q57TU9 ^@ Function|||Similarity ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. http://togogenome.org/gene/185431:Tb927.3.3390 ^@ http://purl.uniprot.org/uniprot/Q57V47 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:TB927.1.2340 ^@ http://purl.uniprot.org/uniprot/Q4GYY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/185431:Tb927.2.4610 ^@ http://purl.uniprot.org/uniprot/Q586R1 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/185431:Tb10.70.1780 ^@ http://purl.uniprot.org/uniprot/Q38B74 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/185431:Tb09.211.0220 ^@ http://purl.uniprot.org/uniprot/Q38ED9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.5.3170 ^@ http://purl.uniprot.org/uniprot/Q57Z76 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/185431:Tb927.7.4180 ^@ http://purl.uniprot.org/uniprot/Q57UP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/185431:Tb10.6k15.2060 ^@ http://purl.uniprot.org/uniprot/Q38AC2 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/185431:Tb10.70.2720 ^@ http://purl.uniprot.org/uniprot/Q4FKP8 ^@ Similarity ^@ In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family. http://togogenome.org/gene/185431:Tb10.70.7695 ^@ http://purl.uniprot.org/uniprot/Q38CI4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/185431:Tb927.8.5590 ^@ http://purl.uniprot.org/uniprot/Q57X23 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/185431:Tb927.4.5250 ^@ http://purl.uniprot.org/uniprot/Q584H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb09.211.4870 ^@ http://purl.uniprot.org/uniprot/Q38D23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||nucleolus http://togogenome.org/gene/185431:Tb927.6.2890 ^@ http://purl.uniprot.org/uniprot/Q583P5 ^@ Similarity ^@ Belongs to the nuclease type I family. http://togogenome.org/gene/185431:Tb09.160.4560 ^@ http://purl.uniprot.org/uniprot/Q38EV2 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/185431:Tb927.7.3680 ^@ http://purl.uniprot.org/uniprot/Q57WI3 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/185431:Tb927.8.1080 ^@ http://purl.uniprot.org/uniprot/Q57VP6 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/185431:Tb927.7.5260 ^@ http://purl.uniprot.org/uniprot/Q57ZG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/185431:Tb10.70.2450 ^@ http://purl.uniprot.org/uniprot/Q38BC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC3 family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.4620 ^@ http://purl.uniprot.org/uniprot/Q38BV1 ^@ Similarity ^@ Belongs to the SNAP family. http://togogenome.org/gene/185431:Tb927.6.2510 ^@ http://purl.uniprot.org/uniprot/Q584Q5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with the flavoprotein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. http://togogenome.org/gene/185431:Tb10.61.1020 ^@ http://purl.uniprot.org/uniprot/Q387X4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb09.211.3920 ^@ http://purl.uniprot.org/uniprot/Q38DB7 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/185431:Tb927.2.4590 ^@ http://purl.uniprot.org/uniprot/Q586R0 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/185431:Tb927.4.5380 ^@ http://purl.uniprot.org/uniprot/Q580P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP43 family.|||Flagellar protein involved in flagellum axoneme organization and function.|||flagellum|||flagellum axoneme http://togogenome.org/gene/185431:Tb10.61.2410 ^@ http://purl.uniprot.org/uniprot/Q388G6 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/185431:Tb09.160.1980 ^@ http://purl.uniprot.org/uniprot/Q38FJ5 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/185431:Tb10.70.7050 ^@ http://purl.uniprot.org/uniprot/Q38CD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. http://togogenome.org/gene/185431:Tb10.6k15.2190 ^@ http://purl.uniprot.org/uniprot/Q38AD3 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/185431:Tb10.6k15.2290 ^@ http://purl.uniprot.org/uniprot/Q38AE1 ^@ Similarity ^@ Belongs to the protein disulfide isomerase family. http://togogenome.org/gene/185431:Tb927.6.3740 ^@ http://purl.uniprot.org/uniprot/Q585X3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/185431:Tb10.61.0340 ^@ http://purl.uniprot.org/uniprot/Q387S0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.1320 ^@ http://purl.uniprot.org/uniprot/Q57WR6 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/185431:Tb927.5.1090 ^@ http://purl.uniprot.org/uniprot/Q57W54 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb927.8.1940 ^@ http://purl.uniprot.org/uniprot/Q581Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/185431:Tb927.2.4210 ^@ http://purl.uniprot.org/uniprot/Q586V2 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. http://togogenome.org/gene/185431:Tb927.4.410 ^@ http://purl.uniprot.org/uniprot/Q57UT4 ^@ Similarity ^@ Belongs to the CNOT9 family. http://togogenome.org/gene/185431:Tb927.6.3550 ^@ http://purl.uniprot.org/uniprot/Q584Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/185431:Tb10.70.5100 ^@ http://purl.uniprot.org/uniprot/Q38BY8 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/185431:Tb927.3.2340 ^@ http://purl.uniprot.org/uniprot/Q582U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/185431:Tb927.7.6060 ^@ http://purl.uniprot.org/uniprot/Q57VK5 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.7.3830 ^@ http://purl.uniprot.org/uniprot/Q57UD0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.7.7290 ^@ http://purl.uniprot.org/uniprot/D6XJQ7 ^@ Similarity ^@ Belongs to the COG4 family. http://togogenome.org/gene/185431:Tb927.7.7450 ^@ http://purl.uniprot.org/uniprot/Q57TY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/185431:Tb10.70.0350 ^@ http://purl.uniprot.org/uniprot/Q38AW0 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb10.6k15.0290 ^@ http://purl.uniprot.org/uniprot/Q389X7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/185431:Tb927.8.6330 ^@ http://purl.uniprot.org/uniprot/Q57YN4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb927.6.1170 ^@ http://purl.uniprot.org/uniprot/Q585D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the APH-1 family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.5830 ^@ http://purl.uniprot.org/uniprot/Q38C43 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/185431:Tb10.6k15.3640 ^@ http://purl.uniprot.org/uniprot/Q38AQ4 ^@ Cofactor|||Similarity ^@ Belongs to the alternative oxidase family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/185431:Tb09.211.0865 ^@ http://purl.uniprot.org/uniprot/Q386L1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/185431:Tb927.3.2850 ^@ http://purl.uniprot.org/uniprot/Q57ZM7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/185431:TB927.1.1620 ^@ http://purl.uniprot.org/uniprot/Q4GZ57 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/185431:Tb927.8.6750 ^@ http://purl.uniprot.org/uniprot/Q57TT8 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/185431:Tb927.4.590 ^@ http://purl.uniprot.org/uniprot/Q57ZY7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.8.1630 ^@ http://purl.uniprot.org/uniprot/Q580G0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/185431:Tb927.7.3940 ^@ http://purl.uniprot.org/uniprot/Q57UM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Membrane|||Monomer. http://togogenome.org/gene/185431:Tb10.61.1990 ^@ http://purl.uniprot.org/uniprot/Q388D6 ^@ Similarity ^@ Belongs to the BRX1 family. http://togogenome.org/gene/185431:Tb09.211.1580 ^@ http://purl.uniprot.org/uniprot/Q38DZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.3.340 ^@ http://purl.uniprot.org/uniprot/Q57TR6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.0790 ^@ http://purl.uniprot.org/uniprot/Q38AZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb927.8.7400 ^@ http://purl.uniprot.org/uniprot/Q57YU2 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/185431:Tb927.7.4160 ^@ http://purl.uniprot.org/uniprot/Q57UP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.1030 ^@ http://purl.uniprot.org/uniprot/Q585E3 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb927.8.6210 ^@ http://purl.uniprot.org/uniprot/Q57YM2 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/185431:Tb10.70.6620 ^@ http://purl.uniprot.org/uniprot/Q38C98 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm http://togogenome.org/gene/185431:Tb927.3.3450 ^@ http://purl.uniprot.org/uniprot/Q57XJ5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/185431:Tb927.4.420 ^@ http://purl.uniprot.org/uniprot/Q57UT3 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/185431:Tb927.7.2420 ^@ http://purl.uniprot.org/uniprot/Q57XN2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/185431:Tb927.3.5400 ^@ http://purl.uniprot.org/uniprot/Q580T5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/185431:Tb927.3.4390 ^@ http://purl.uniprot.org/uniprot/Q580K3 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/185431:Tb09.211.3270 ^@ http://purl.uniprot.org/uniprot/Q38DH8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/185431:Tb10.70.0670 ^@ http://purl.uniprot.org/uniprot/Q38AZ0 ^@ Similarity ^@ Belongs to the COG3 family. http://togogenome.org/gene/185431:Tb927.3.4160 ^@ http://purl.uniprot.org/uniprot/Q580M6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/185431:Tb10.26.0940 ^@ http://purl.uniprot.org/uniprot/Q389M9 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/185431:Tb927.5.4420 ^@ http://purl.uniprot.org/uniprot/Q57Z07 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/185431:Tb927.7.3070 ^@ http://purl.uniprot.org/uniprot/Q57YB7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.211.3630 ^@ http://purl.uniprot.org/uniprot/Q38DE6 ^@ Similarity ^@ Belongs to the complex I NDUFA12 subunit family. http://togogenome.org/gene/185431:Tb927.6.940 ^@ http://purl.uniprot.org/uniprot/Q585F3 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by Ca(2+) (PubMed:18005666, PubMed:23506317, PubMed:28089596, PubMed:22529389). In response to calcium binding, the 280-loop, a disordered loop consisting of residues 269-275, undergoes a conformational change which stabilizes substrates in the active site (PubMed:22529389). The binding to the substrate triggers the release of the N-terminal region resulting in the activation of the enzyme (PubMed:22529389). Proteolytic cleavage is required for catalytic activity towards large protein substrates (PubMed:28089596).|||Auto-proteolytic cleavage of the propeptide after Lys-55 and between the large and small subunits after Lys-268 is required for catalytic activity towards large protein substrates but is dispensable towards small oligopeptide substrates (PubMed:18005666, PubMed:28089596, PubMed:22529389). After processing, the propeptide and the large and small subunits remain associated by non-covalent bonds (PubMed:18005666). In vivo, the unprocessed enzyme appears to be the predominant form (By similarity).|||Belongs to the peptidase C14B family.|||Cysteine protease that cleaves specifically after arginine or lysine residues.|||Monomer.|||Recycling endosome|||There are 2 calcium binding sites with high and low affinity, respectively. http://togogenome.org/gene/185431:Tb927.4.1500 ^@ http://purl.uniprot.org/uniprot/Q581T1 ^@ Developmental Stage|||Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase that unwinds RNA in a 3' to 5' direction and that plays an important role in mitochondrial mRNA editing, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA (PubMed:19850921, PubMed:26769962, PubMed:31034523). As part of the RET2-containing gRNA-binding (RET2-GRBC) complex, acts as a scaffold for the assembly of mRNA-gRNA hybrids and the recruitment of the RNA editing core (RECC) complex (PubMed:25928631, PubMed:26769962). Regulates several steps of mRNA editing by the MRBC3010/GRBC6 containing gRNA-binding (MRBC3010-GRBC) complex including loading of unedited mRNA, editing in the first sequence block and subsequent editing progression across multiple sequence blocks (PubMed:25928631). Also, regulates the RNA substrate content of the MRBC3010-GRBC complex as well as the association of this complex with mitoribosomes (PubMed:25928631).|||Belongs to the DEAD box helicase family. DEAH subfamily.|||Component of the REH2-associated complex (REH2C) composed of helicase REH2, associated factors H2F1 and H2F2, and mRNAs at various editing stages; the formation of the complex is RNA-independent (PubMed:26769962, PubMed:31034523). Within the complex, interacts with H2F1; the interaction is direct (PubMed:26769962, PubMed:31034523). Interacts transiently, in a RNA-dependent manner, with various editing complexes including the RNA editing core (RECC) complex, the gRNA-binding (GRBC) complex (also known as the MRB1 complex) and the RNA editing mediator (REMC) complex (PubMed:19850921, PubMed:25928631, PubMed:26769962, PubMed:31034523). Interacts with GAP1/GRBC2 via RNA forming a variant of the GRBC complex known as REH2-GRBC complex (PubMed:19850921, PubMed:25928631, PubMed:26769962, PubMed:31034523). Interacts with mitochondrial ribosomes (PubMed:19850921).|||Expressed at the procyclic stage (at protein level).|||Mitochondrion|||RNAi-mediated knockdown at the procyclic stage causes a loss of RNA unwinding activity (PubMed:26769962). Reduces association of H2F1 and abolishes H2F2 association with components of various editing complexes (PubMed:26769962). RNAi-mediated knockdown at the procyclic stage inhibits editing at early 3' sites on pre-mRNA substrates without affecting the interactions between MRB3010/GRBC6, GAP1/GRBC2, RGG2, REL1 and gRNA (PubMed:25928631). Decreases the ratio of unedited mRNA substrates in the MRB3010/GRBC6-MRB complex and the association of never-edited mRNA and 9SrRNA with the MRB3010-MRB complex (PubMed:25928631). Also, causes a decrease in the steady-state levels of guide RNA (gRNA) (PubMed:19850921).|||The DRBM domain is required for binding to guide RNAs (gRNA) and mRNAs which facilitates the association with the GRBC complex. http://togogenome.org/gene/185431:Tb927.6.1310 ^@ http://purl.uniprot.org/uniprot/Q585B6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.5.4530 ^@ http://purl.uniprot.org/uniprot/Q57X51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/185431:Tb927.4.3620 ^@ http://purl.uniprot.org/uniprot/Q585I8 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb927.3.3580 ^@ http://purl.uniprot.org/uniprot/Q57W94 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/185431:Tb927.7.2530 ^@ http://purl.uniprot.org/uniprot/Q57XM1 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNAT subfamily. http://togogenome.org/gene/185431:Tb09.160.3210 ^@ http://purl.uniprot.org/uniprot/Q38F81 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/185431:Tb927.7.1770 ^@ http://purl.uniprot.org/uniprot/Q57V33 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.7.3650 ^@ http://purl.uniprot.org/uniprot/Q57WI0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.5.4950 ^@ http://purl.uniprot.org/uniprot/Q57XG6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.1860 ^@ http://purl.uniprot.org/uniprot/Q581Z6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/185431:Tb10.61.0420 ^@ http://purl.uniprot.org/uniprot/Q387S7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.6.2330 ^@ http://purl.uniprot.org/uniprot/Q584S3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/185431:Tb927.4.4960 ^@ http://purl.uniprot.org/uniprot/Q584K9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.211.1690 ^@ http://purl.uniprot.org/uniprot/Q38DY5 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/185431:Tb10.61.0110 ^@ http://purl.uniprot.org/uniprot/Q387Q0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb927.8.3730 ^@ http://purl.uniprot.org/uniprot/Q580Z3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.6620 ^@ http://purl.uniprot.org/uniprot/Q57Y67 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb09.211.2780 ^@ http://purl.uniprot.org/uniprot/Q38DM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/185431:Tb927.6.4870 ^@ http://purl.uniprot.org/uniprot/Q586F9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/185431:Tb927.6.4860 ^@ http://purl.uniprot.org/uniprot/Q586G3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/185431:Tb927.3.4840 ^@ http://purl.uniprot.org/uniprot/Q582Q1 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/185431:Tb927.2.5030 ^@ http://purl.uniprot.org/uniprot/Q586U1 ^@ Similarity ^@ Belongs to the SPT5 family. http://togogenome.org/gene/185431:Tb927.4.4990 ^@ http://purl.uniprot.org/uniprot/Q584K6 ^@ Similarity ^@ Belongs to the UQCRH/QCR6 family. http://togogenome.org/gene/185431:Tb927.3.2240 ^@ http://purl.uniprot.org/uniprot/Q582T7 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/185431:TB927.1.3830 ^@ http://purl.uniprot.org/uniprot/Q4GYJ4 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/185431:Tb09.211.0180 ^@ http://purl.uniprot.org/uniprot/Q38EE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pescadillo family.|||Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.|||nucleolus|||nucleoplasm http://togogenome.org/gene/185431:Tb09.211.2640 ^@ http://purl.uniprot.org/uniprot/Q38DP2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/185431:Tb927.8.870 ^@ http://purl.uniprot.org/uniprot/Q57YE4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.3.1510 ^@ http://purl.uniprot.org/uniprot/Q57XY4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.570 ^@ http://purl.uniprot.org/uniprot/Q57YH3 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/185431:Tb927.2.3720 ^@ http://purl.uniprot.org/uniprot/Q586X5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/185431:Tb09.211.0510 ^@ http://purl.uniprot.org/uniprot/Q38EA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCO1/2 family.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.5.4770 ^@ http://purl.uniprot.org/uniprot/Q57X38 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.406.0410 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.70.5120 ^@ http://purl.uniprot.org/uniprot/Q38BZ0 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/185431:Tb10.100.0170 ^@ http://purl.uniprot.org/uniprot/Q38CK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. http://togogenome.org/gene/185431:Tb927.7.3890 ^@ http://purl.uniprot.org/uniprot/Q57UL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.7.1730 ^@ http://purl.uniprot.org/uniprot/Q57V37 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/185431:Tb10.61.0880 ^@ http://purl.uniprot.org/uniprot/Q387W4 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/185431:Tb09.160.4310 ^@ http://purl.uniprot.org/uniprot/Q38EX6 ^@ Function|||Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. http://togogenome.org/gene/185431:Tb927.6.3840 ^@ http://purl.uniprot.org/uniprot/Q585Y2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.7.1000 ^@ http://purl.uniprot.org/uniprot/Q57VU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||Monomer.|||Required for the maintenance of mitochondrial (kinetoplast) genome stability. Essential for cell viability. Has probably no helicase activity, missing at least two of seven conserved helicase motifs.|||kinetoplast http://togogenome.org/gene/185431:Tb927.6.1090 ^@ http://purl.uniprot.org/uniprot/D6XHJ3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb927.5.1520 ^@ http://purl.uniprot.org/uniprot/Q57VB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex (HslVU) is dependent on binding of ATP (By similarity).|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity). The HslVU protease complex functions in mitochondrial DNA replication by regulating DNA helicase PIF2 protein levels.|||Belongs to the ClpX chaperone family. HslU subfamily.|||kinetoplast http://togogenome.org/gene/185431:Tb09.160.5390 ^@ http://purl.uniprot.org/uniprot/Q38EL3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.v1.0290 ^@ http://purl.uniprot.org/uniprot/Q38EK9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.5270 ^@ http://purl.uniprot.org/uniprot/Q580U8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.6.960 ^@ http://purl.uniprot.org/uniprot/Q585F0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb927.7.2890 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.2.2900 ^@ http://purl.uniprot.org/uniprot/Q587H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.2.6240 ^@ http://purl.uniprot.org/uniprot/Q586M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.4850 ^@ http://purl.uniprot.org/uniprot/Q586G3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/185431:Tb927.3.3100 ^@ http://purl.uniprot.org/uniprot/Q57ZK2 ^@ Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. http://togogenome.org/gene/185431:Tb927.5.580 ^@ http://purl.uniprot.org/uniprot/Q57VV5 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/185431:Tb927.3.210 ^@ http://purl.uniprot.org/uniprot/Q57TR7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.3410 ^@ http://purl.uniprot.org/uniprot/Q57V45 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/185431:Tb10.70.2290 ^@ http://purl.uniprot.org/uniprot/Q38BB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.4280 ^@ http://purl.uniprot.org/uniprot/Q38BS5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/185431:Tb927.5.230 ^@ http://purl.uniprot.org/uniprot/Q57XH3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.2200 ^@ http://purl.uniprot.org/uniprot/Q581W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb09.211.4350 ^@ http://purl.uniprot.org/uniprot/Q38D76 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/185431:Tb09.211.3460 ^@ http://purl.uniprot.org/uniprot/Q38DG0 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/185431:Tb09.160.1140 ^@ http://purl.uniprot.org/uniprot/Q38FS2 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/185431:Tb927.8.6690 ^@ http://purl.uniprot.org/uniprot/Q57TU4 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/185431:Tb927.7.3000 ^@ http://purl.uniprot.org/uniprot/Q57YB0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.6.1760 ^@ http://purl.uniprot.org/uniprot/Q585N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.7.1690 ^@ http://purl.uniprot.org/uniprot/Q57V41 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit.|||NAD-dependent protein deacetylase, which is involved in repression of RNA polymerase I-mediated expression immediately adjacent to telomeres. It is however not involved in antigenic variation and subtelomeric variant surface glycoprotein (VSG) gene silencing. Plays a role in DNA damage response. Also has ADP-ribosylation activity in vitro.|||Nucleus|||telomere http://togogenome.org/gene/185431:Tb927.6.180 ^@ http://purl.uniprot.org/uniprot/Q57WZ9 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb09.160.1990 ^@ http://purl.uniprot.org/uniprot/Q38FJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.4.5430 ^@ http://purl.uniprot.org/uniprot/Q580P4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.3850 ^@ http://purl.uniprot.org/uniprot/Q57WC1 ^@ Similarity ^@ Belongs to the SEC16 family. http://togogenome.org/gene/185431:Tb927.7.6070 ^@ http://purl.uniprot.org/uniprot/Q57VK4 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.3.5500 ^@ http://purl.uniprot.org/uniprot/Q580S5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/185431:Tb10.61.1310 ^@ http://purl.uniprot.org/uniprot/Q387Z1 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/185431:Tb927.4.5270 ^@ http://purl.uniprot.org/uniprot/Q584H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.3.5680 ^@ http://purl.uniprot.org/uniprot/Q57VH5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.5650 ^@ http://purl.uniprot.org/uniprot/P86934|||http://purl.uniprot.org/uniprot/P86939 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Phosphatidylethanolamine (PE) is a direct precursor of the ethanolamine-phosphoglycerol (EPG) moiety.|||The Kennedy pathway is the major route for phosphatidylethanolamine (PE) synthesis, as shown by reduced levels after using RNAi against the first two enzymes of the Kennedy pathway.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/185431:Tb927.3.440 ^@ http://purl.uniprot.org/uniprot/Q57TR4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.4860 ^@ http://purl.uniprot.org/uniprot/Q582P9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.7.7140 ^@ http://purl.uniprot.org/uniprot/Q57XT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/185431:Tb927.3.4490 ^@ http://purl.uniprot.org/uniprot/Q580J3 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/185431:TB927.1.1350 ^@ http://purl.uniprot.org/uniprot/Q4GZ84 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb10.6k15.2520 ^@ http://purl.uniprot.org/uniprot/Q38AG2 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/185431:Tb10.v4.0024 ^@ http://purl.uniprot.org/uniprot/Q387P2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.406.0400 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.7.4570 ^@ http://purl.uniprot.org/uniprot/Q57X73 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/185431:Tb927.5.3710 ^@ http://purl.uniprot.org/uniprot/Q57U95 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/185431:Tb927.8.6110 ^@ http://purl.uniprot.org/uniprot/Q57YL2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family. http://togogenome.org/gene/185431:Tb10.26.0320 ^@ http://purl.uniprot.org/uniprot/Q389I2 ^@ Similarity ^@ Belongs to the NAPRTase family. http://togogenome.org/gene/185431:Tb10.6k15.3110 ^@ http://purl.uniprot.org/uniprot/Q38AL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/185431:TB927.1.2390 ^@ http://purl.uniprot.org/uniprot/Q4GYY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/185431:Tb927.4.3740 ^@ http://purl.uniprot.org/uniprot/Q585H6 ^@ Disruption Phenotype|||Function|||Subcellular Location Annotation ^@ A component of FAZ filament that is required for correct FAZ assembly and attachment. Not essential for new flagellum growth.|||Assembly of a compromised FAZ and defects in flagellum attachment and cytokinesis in procyclic trypanosomes resulting in generation of 0N1K cells (zoids) and multinucleated cells, demonstrates the role of an attached flagellum in cellular morphogenesis.|||flagellum http://togogenome.org/gene/185431:Tb927.4.2860 ^@ http://purl.uniprot.org/uniprot/Q583W3 ^@ Similarity ^@ Belongs to the SNF8 family. http://togogenome.org/gene/185431:Tb10.70.5840 ^@ http://purl.uniprot.org/uniprot/Q38C44 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Nucleus|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.|||The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). http://togogenome.org/gene/185431:Tb927.4.3950 ^@ http://purl.uniprot.org/uniprot/Q57XZ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.7.2230 ^@ http://purl.uniprot.org/uniprot/Q57XQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb09.354.0090 ^@ http://purl.uniprot.org/uniprot/Q38G46 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.4510 ^@ http://purl.uniprot.org/uniprot/Q583D6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/185431:Tb10.389.0340 ^@ http://purl.uniprot.org/uniprot/Q388T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.5120 ^@ http://purl.uniprot.org/uniprot/Q57UI4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/185431:Tb10.61.3070 ^@ http://purl.uniprot.org/uniprot/Q388L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.8.7560 ^@ http://purl.uniprot.org/uniprot/Q57V77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.1400 ^@ http://purl.uniprot.org/uniprot/Q38E15 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.6.1500 ^@ http://purl.uniprot.org/uniprot/Q585R0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family.|||Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.|||Homodimer.|||Peroxisome http://togogenome.org/gene/185431:Tb927.8.8100 ^@ http://purl.uniprot.org/uniprot/Q57WM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb10.70.0370 ^@ http://purl.uniprot.org/uniprot/Q38AW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/185431:Tb10.70.3160 ^@ http://purl.uniprot.org/uniprot/Q38BI8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/185431:Tb927.7.4970 ^@ http://purl.uniprot.org/uniprot/Q57ZJ2 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/185431:Tb927.6.2060 ^@ http://purl.uniprot.org/uniprot/Q584V0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb927.6.2360 ^@ http://purl.uniprot.org/uniprot/Q584S0 ^@ Function|||Similarity ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/185431:Tb10.61.0060 ^@ http://purl.uniprot.org/uniprot/Q387P6 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.7.7470 ^@ http://purl.uniprot.org/uniprot/Q57TY4 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.70.1730 ^@ http://purl.uniprot.org/uniprot/Q38B69 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/185431:Tb927.6.1400 ^@ http://purl.uniprot.org/uniprot/Q585A7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.5.1110 ^@ http://purl.uniprot.org/uniprot/Q57W56 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/185431:Tb927.2.1810 ^@ http://purl.uniprot.org/uniprot/Q585S8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb09.211.3130 ^@ http://purl.uniprot.org/uniprot/Q38DJ3 ^@ Function|||Subcellular Location Annotation ^@ Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.|||Virion http://togogenome.org/gene/185431:Tb10.6k15.1130 ^@ http://purl.uniprot.org/uniprot/Q38A47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.4870 ^@ http://purl.uniprot.org/uniprot/Q38BW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/185431:Tb927.6.2140 ^@ http://purl.uniprot.org/uniprot/Q584U2 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Subcellular Location Annotation|||Subunit ^@ Component of the REH2-associated complex (REH2C) composed of helicase REH2, associated factors H2F1 and H2F2, and mRNAs at various editing stages; the formation of the complex is RNA-independent (PubMed:26769962). Interacts with various editing complexes including the RNA editing core (RECC) complex, the gRNA-binding (GRBC) complex (also known as the MRB1 complex) and the RNA editing mediator (REMC) complex (PubMed:26769962).|||Expressed at the procyclic stage (at protein level).|||May play a role in mitochondrial mRNA editing by facilitating the association of the gRNA-binding (GRBC) complex with the RNA editing core (RECC) complex (PubMed:26769962). However, appears to be dispensable for mRNA editing per se (PubMed:26769962).|||Mitochondrion|||RNAi-mediated knockdown at the procyclic stage does not cause defects in RHE2 interaction with H2F1 or their association with components of the RECC and GRBC editing complexes; however, causes a slight decrease in the association of the GRBC complex with the RECC complex (PubMed:26769962). No defect in mitochondrial mRNA editing (PubMed:26769962). http://togogenome.org/gene/185431:Tb927.2.2440 ^@ http://purl.uniprot.org/uniprot/Q586L6 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/185431:Tb10.6k15.0580 ^@ http://purl.uniprot.org/uniprot/Q38A02 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb10.6k15.4010 ^@ http://purl.uniprot.org/uniprot/Q38AT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/185431:Tb927.5.1250 ^@ http://purl.uniprot.org/uniprot/Q57VD8 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/185431:Tb927.5.4330 ^@ http://purl.uniprot.org/uniprot/Q57Z16 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/185431:Tb927.2.2160 ^@ http://purl.uniprot.org/uniprot/Q586J7 ^@ Similarity ^@ Belongs to the SNAP family. http://togogenome.org/gene/185431:Tb927.4.1050 ^@ http://purl.uniprot.org/uniprot/Q580D3 ^@ Domain|||Function ^@ Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/185431:Tb09.160.2460 ^@ http://purl.uniprot.org/uniprot/Q38FE7 ^@ Similarity ^@ Belongs to the dymeclin family. http://togogenome.org/gene/185431:TB927.1.3820 ^@ http://purl.uniprot.org/uniprot/Q4GYJ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/185431:TB927.1.4890 ^@ http://purl.uniprot.org/uniprot/Q4GY91 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.3910 ^@ http://purl.uniprot.org/uniprot/Q57WC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/185431:Tb927.7.1140 ^@ http://purl.uniprot.org/uniprot/D6XK32 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/185431:Tb10.05.0210 ^@ http://purl.uniprot.org/uniprot/Q388P9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.2.2500 ^@ http://purl.uniprot.org/uniprot/Q586M1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.4.2180 ^@ http://purl.uniprot.org/uniprot/Q584G9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/185431:Tb09.160.4590 ^@ http://purl.uniprot.org/uniprot/Q38EU9 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/185431:Tb927.4.1840 ^@ http://purl.uniprot.org/uniprot/Q583K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Midbody|||Nucleus|||spindle http://togogenome.org/gene/185431:Tb10.6k15.1620 ^@ http://purl.uniprot.org/uniprot/Q38A87 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/185431:Tb927.5.1280 ^@ http://purl.uniprot.org/uniprot/Q57VD5 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/185431:Tb09.244.2650 ^@ http://purl.uniprot.org/uniprot/Q38CX5 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/185431:Tb10.389.1150 ^@ http://purl.uniprot.org/uniprot/Q388Z0 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/185431:Tb10.6k15.2380 ^@ http://purl.uniprot.org/uniprot/Q38AF0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.5.3270 ^@ http://purl.uniprot.org/uniprot/Q57Z66 ^@ Similarity ^@ Belongs to the beclin family. http://togogenome.org/gene/185431:Tb09.211.1380 ^@ http://purl.uniprot.org/uniprot/Q38E17 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/185431:Tb927.3.3020 ^@ http://purl.uniprot.org/uniprot/Q57ZL0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/185431:Tb927.4.4760 ^@ http://purl.uniprot.org/uniprot/Q583G1 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/185431:Tb09.211.3470 ^@ http://purl.uniprot.org/uniprot/Q38DF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.7.2860 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.8.4950 ^@ http://purl.uniprot.org/uniprot/Q57UV7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb10.61.1750 ^@ http://purl.uniprot.org/uniprot/Q388B7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.7.3530 ^@ http://purl.uniprot.org/uniprot/Q57WG8 ^@ Similarity ^@ Belongs to the VAC14 family. http://togogenome.org/gene/185431:Tb10.389.0690 ^@ http://purl.uniprot.org/uniprot/Q388W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb10.61.1330 ^@ http://purl.uniprot.org/uniprot/Q387Z3 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/185431:Tb09.244.2380 ^@ http://purl.uniprot.org/uniprot/Q38CU7 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.2.6220 ^@ http://purl.uniprot.org/uniprot/Q586N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.4840 ^@ http://purl.uniprot.org/uniprot/Q586G3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/185431:Tb927.7.5450 ^@ http://purl.uniprot.org/uniprot/Q582G0 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/185431:Tb927.2.2370 ^@ http://purl.uniprot.org/uniprot/Q586L0 ^@ Similarity ^@ Belongs to the COG1 family. http://togogenome.org/gene/185431:TB927.1.4500 ^@ http://purl.uniprot.org/uniprot/Q4GYC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.1470 ^@ http://purl.uniprot.org/uniprot/Q57WQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/185431:Tb09.142.0230 ^@ http://purl.uniprot.org/uniprot/Q38G42 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.0550 ^@ http://purl.uniprot.org/uniprot/Q38AX8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.|||Monomer. http://togogenome.org/gene/185431:Tb10.389.1450 ^@ http://purl.uniprot.org/uniprot/Q389B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb10.61.0440 ^@ http://purl.uniprot.org/uniprot/Q387S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/185431:Tb927.7.5210 ^@ http://purl.uniprot.org/uniprot/Q57ZG8 ^@ Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily. http://togogenome.org/gene/185431:Tb09.v1.0300 ^@ http://purl.uniprot.org/uniprot/Q38EK8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.6800 ^@ http://purl.uniprot.org/uniprot/Q38CB4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. http://togogenome.org/gene/185431:Tb927.5.4260 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.3.1120 ^@ http://purl.uniprot.org/uniprot/Q57WZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/185431:Tb10.406.0340 ^@ http://purl.uniprot.org/uniprot/Q389S0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.8.5720 ^@ http://purl.uniprot.org/uniprot/Q57X10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/185431:Tb927.6.4980 ^@ http://purl.uniprot.org/uniprot/Q4FKG9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/185431:Tb927.5.550 ^@ http://purl.uniprot.org/uniprot/Q57VV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/185431:Tb10.70.4800 ^@ http://purl.uniprot.org/uniprot/Q57XX0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/185431:Tb927.7.270 ^@ http://purl.uniprot.org/uniprot/Q57U27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/185431:Tb927.8.3530 ^@ http://purl.uniprot.org/uniprot/Q57YW0 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/185431:Tb10.406.0360 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.5.3360 ^@ http://purl.uniprot.org/uniprot/Q57Z57 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/185431:Tb09.211.0540 ^@ http://purl.uniprot.org/uniprot/Q38EA4 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/185431:Tb10.26.0220 ^@ http://purl.uniprot.org/uniprot/Q389H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/185431:Tb927.5.2080 ^@ http://purl.uniprot.org/uniprot/Q57ZS7 ^@ Similarity ^@ Belongs to the IMPDH/GMPR family. http://togogenome.org/gene/185431:Tb10.61.1530 ^@ http://purl.uniprot.org/uniprot/Q388A7 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/185431:Tb10.70.7080 ^@ http://purl.uniprot.org/uniprot/Q38CD5 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/185431:Tb09.160.4850 ^@ http://purl.uniprot.org/uniprot/Q38ES2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/185431:Tb10.70.0480 ^@ http://purl.uniprot.org/uniprot/Q38AX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||cytoskeleton http://togogenome.org/gene/185431:Tb10.6k15.1940 ^@ http://purl.uniprot.org/uniprot/Q38AB2 ^@ Similarity ^@ Belongs to the VPS54 family. http://togogenome.org/gene/185431:Tb10.61.0910 ^@ http://purl.uniprot.org/uniprot/Q387W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/185431:Tb10.6k15.3820 ^@ http://purl.uniprot.org/uniprot/Q4FKJ2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. http://togogenome.org/gene/185431:Tb10.6k15.0020 ^@ http://purl.uniprot.org/uniprot/Q389V1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Major surface antigen of procyclic forms.|||Membrane http://togogenome.org/gene/185431:Tb927.7.1740 ^@ http://purl.uniprot.org/uniprot/Q57V35 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/185431:Tb10.70.0750 ^@ http://purl.uniprot.org/uniprot/Q38AZ4 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/185431:Tb927.8.5260 ^@ http://purl.uniprot.org/uniprot/Q57UJ8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/185431:Tb927.8.2520 ^@ http://purl.uniprot.org/uniprot/Q57XD7 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/185431:Tb927.8.3200 ^@ http://purl.uniprot.org/uniprot/Q57YZ3 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/185431:Tb10.70.4090 ^@ http://purl.uniprot.org/uniprot/Q38BR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.3500 ^@ http://purl.uniprot.org/uniprot/Q57WG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GST superfamily.|||Membrane http://togogenome.org/gene/185431:Tb927.5.1310 ^@ http://purl.uniprot.org/uniprot/Q57VD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/185431:Tb927.6.3250 ^@ http://purl.uniprot.org/uniprot/Q584W8 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/185431:Tb10.70.1670 ^@ http://purl.uniprot.org/uniprot/Q38B66 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/185431:Tb927.7.6930 ^@ http://purl.uniprot.org/uniprot/Q57XR3 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/185431:Tb10.6k15.3140 ^@ http://purl.uniprot.org/uniprot/Q38AL2 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/185431:Tb927.6.1060 ^@ http://purl.uniprot.org/uniprot/Q585E2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb927.2.6200 ^@ http://purl.uniprot.org/uniprot/Q586N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:TB927.1.2400 ^@ http://purl.uniprot.org/uniprot/Q4GYY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/185431:Tb927.4.5370 ^@ http://purl.uniprot.org/uniprot/Q580Q0 ^@ Similarity ^@ Belongs to the GAMAD family. http://togogenome.org/gene/185431:Tb10.70.4060 ^@ http://purl.uniprot.org/uniprot/Q38BQ9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/185431:Tb927.3.4020 ^@ http://purl.uniprot.org/uniprot/Q57WD8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/185431:Tb927.5.4220 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.3.5640 ^@ http://purl.uniprot.org/uniprot/Q57VH9 ^@ Similarity ^@ Belongs to the NFX1 family. http://togogenome.org/gene/185431:Tb927.6.2600 ^@ http://purl.uniprot.org/uniprot/Q584P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.8.5230 ^@ http://purl.uniprot.org/uniprot/Q57UJ5 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.4.1780 ^@ http://purl.uniprot.org/uniprot/Q581Q3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.4.3380 ^@ http://purl.uniprot.org/uniprot/Q585L2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/185431:Tb927.5.4230 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.8.6460 ^@ http://purl.uniprot.org/uniprot/Q57YP7 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/185431:Tb927.8.1620 ^@ http://purl.uniprot.org/uniprot/Q580G0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/185431:Tb10.389.1060 ^@ http://purl.uniprot.org/uniprot/Q388Y3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/185431:Tb10.6k15.0390 ^@ http://purl.uniprot.org/uniprot/Q389Y6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/185431:Tb09.211.2550 ^@ http://purl.uniprot.org/uniprot/Q38DQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/185431:Tb927.5.3830 ^@ http://purl.uniprot.org/uniprot/Q57U83 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/185431:Tb10.389.1530 ^@ http://purl.uniprot.org/uniprot/Q389C2 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/185431:Tb10.61.0210 ^@ http://purl.uniprot.org/uniprot/Q387Q8 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/185431:Tb09.244.2560 ^@ http://purl.uniprot.org/uniprot/Q38CW6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.7.5830 ^@ http://purl.uniprot.org/uniprot/Q582J8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/185431:Tb10.70.4860 ^@ http://purl.uniprot.org/uniprot/Q38BW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/185431:Tb09.160.0840 ^@ http://purl.uniprot.org/uniprot/Q38FV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/185431:Tb927.5.3050 ^@ http://purl.uniprot.org/uniprot/Q57ZY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.8.4410 ^@ http://purl.uniprot.org/uniprot/Q57VZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/185431:Tb10.389.1800 ^@ http://purl.uniprot.org/uniprot/Q389E4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/185431:TB927.1.1990 ^@ http://purl.uniprot.org/uniprot/Q4GZ20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/185431:Tb927.7.1590 ^@ http://purl.uniprot.org/uniprot/Q57WP1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/185431:Tb927.6.4990 ^@ http://purl.uniprot.org/uniprot/Q586H1 ^@ Similarity ^@ Belongs to the ATPase epsilon chain family. http://togogenome.org/gene/185431:Tb10.389.1310 ^@ http://purl.uniprot.org/uniprot/Q389A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb09.160.4150 ^@ http://purl.uniprot.org/uniprot/Q38EZ0 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.|||E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/185431:Tb09.211.0100 ^@ http://purl.uniprot.org/uniprot/Q38EF1 ^@ Similarity ^@ Belongs to the WASH1 family. http://togogenome.org/gene/185431:Tb927.6.970 ^@ http://purl.uniprot.org/uniprot/Q585F0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb927.5.4170 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.3.3310 ^@ http://purl.uniprot.org/uniprot/Q57V55 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/185431:Tb927.6.310 ^@ http://purl.uniprot.org/uniprot/Q581E3 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.7.7500 ^@ http://purl.uniprot.org/uniprot/Q57TY7 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb09.160.5560 ^@ http://purl.uniprot.org/uniprot/Q38EJ2 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/185431:Tb927.4.1130 ^@ http://purl.uniprot.org/uniprot/Q580E1 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/185431:Tb927.7.3430 ^@ http://purl.uniprot.org/uniprot/Q57WF8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.2.4890 ^@ http://purl.uniprot.org/uniprot/Q586R9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/185431:Tb09.160.4180 ^@ http://purl.uniprot.org/uniprot/Q38EY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.|||Early endosome membrane|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/185431:Tb927.5.2060 ^@ http://purl.uniprot.org/uniprot/Q57ZS5 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/185431:Tb927.3.2210 ^@ http://purl.uniprot.org/uniprot/Q582T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/185431:Tb09.244.2820 ^@ http://purl.uniprot.org/uniprot/Q38CZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus http://togogenome.org/gene/185431:Tb927.7.5770 ^@ http://purl.uniprot.org/uniprot/Q582J2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.7.2840 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb09.244.0250 ^@ http://purl.uniprot.org/uniprot/Q38CN2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.1600 ^@ http://purl.uniprot.org/uniprot/Q580G3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb10.26.0260 ^@ http://purl.uniprot.org/uniprot/Q389H7 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences. http://togogenome.org/gene/185431:Tb09.160.2910 ^@ http://purl.uniprot.org/uniprot/Q38FB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.170 ^@ http://purl.uniprot.org/uniprot/Q57X00 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.7.3320 ^@ http://purl.uniprot.org/uniprot/Q57WE7 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/185431:Tb927.3.1710 ^@ http://purl.uniprot.org/uniprot/Q57ZE0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/185431:Tb927.6.540 ^@ http://purl.uniprot.org/uniprot/Q581G2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.6.2400 ^@ http://purl.uniprot.org/uniprot/Q584R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/185431:Tb09.244.0200 ^@ http://purl.uniprot.org/uniprot/Q38CN1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.211.1870 ^@ http://purl.uniprot.org/uniprot/Q38DW7 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/185431:Tb09.211.3330 ^@ http://purl.uniprot.org/uniprot/Q38DH3 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/185431:Tb927.5.2950 ^@ http://purl.uniprot.org/uniprot/Q57ZX1 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/185431:Tb927.8.3690 ^@ http://purl.uniprot.org/uniprot/Q580Y9 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/185431:Tb927.6.330 ^@ http://purl.uniprot.org/uniprot/Q581E4 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.6.470 ^@ http://purl.uniprot.org/uniprot/Q581F5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.2610 ^@ http://purl.uniprot.org/uniprot/Q582X3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.|||Membrane http://togogenome.org/gene/185431:Tb927.2.1700 ^@ http://purl.uniprot.org/uniprot/Q585S0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.6.3520 ^@ http://purl.uniprot.org/uniprot/Q584Z2 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/185431:Tb927.8.4840 ^@ http://purl.uniprot.org/uniprot/Q57UW8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.6.4900 ^@ http://purl.uniprot.org/uniprot/Q586G3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/185431:Tb927.8.2920 ^@ http://purl.uniprot.org/uniprot/Q57W81 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/185431:Tb927.4.4650 ^@ http://purl.uniprot.org/uniprot/Q583F0 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/185431:Tb927.4.470 ^@ http://purl.uniprot.org/uniprot/Q57US8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/185431:Tb927.8.2930 ^@ http://purl.uniprot.org/uniprot/Q57W80 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/185431:Tb09.211.4480 ^@ http://purl.uniprot.org/uniprot/Q38D64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/185431:Tb927.6.2110 ^@ http://purl.uniprot.org/uniprot/Q584U5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS30 family. http://togogenome.org/gene/185431:Tb927.6.2970 ^@ http://purl.uniprot.org/uniprot/Q583N7 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/185431:Tb927.8.2940 ^@ http://purl.uniprot.org/uniprot/Q57W79 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/185431:Tb927.5.4190 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb09.244.2310 ^@ http://purl.uniprot.org/uniprot/Q38CU3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.5260 ^@ http://purl.uniprot.org/uniprot/Q584H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.4.750 ^@ http://purl.uniprot.org/uniprot/Q580A3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family. http://togogenome.org/gene/185431:Tb927.8.2640 ^@ http://purl.uniprot.org/uniprot/Q57XC5 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/185431:Tb927.7.430 ^@ http://purl.uniprot.org/uniprot/Q57U11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.8.5860 ^@ http://purl.uniprot.org/uniprot/Q57YI7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/185431:Tb927.4.4430 ^@ http://purl.uniprot.org/uniprot/Q583C8 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.3.5610 ^@ http://purl.uniprot.org/uniprot/Q580R4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/185431:Tb10.406.0420 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.70.6180 ^@ http://purl.uniprot.org/uniprot/Q38C70 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/185431:Tb927.3.1290 ^@ http://purl.uniprot.org/uniprot/Q57XW2 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/185431:Tb927.4.3910 ^@ http://purl.uniprot.org/uniprot/Q57XZ5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb10.70.4900 ^@ http://purl.uniprot.org/uniprot/Q38BX0 ^@ Activity Regulation|||Cofactor|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by DHSp. Inhibited by spermididine analog N1-guanyl-1,7-diamineoheptane (GC7).|||Belongs to the deoxyhypusine synthase family.|||Heterotetramer formed by a homodimer of the non-catalytic regulatory subunit DHSp and a homodimer of the catalytic subunit DHSc where DHSc appears to bind spermidine and DHSp appears to bind NAD(+).|||In association with the non-catalytic regulatory subunit DHSp, catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF5A precursor protein to form the intermediate deoxyhypusine residue. Regulates protein levels of its regulatory subunit DHSp. Required for cell growth and survival.|||Membrane|||RNAi-mediated knockdown causes cell growth arrest followed by death, loss of DHSp expression and a failure to sustain infection in mice.|||The binding sites for NAD(+) are contained in the regulatory subunit DHSp. http://togogenome.org/gene/185431:Tb10.70.0960 ^@ http://purl.uniprot.org/uniprot/Q38B10 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb10.05.0110 ^@ http://purl.uniprot.org/uniprot/Q388N2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/185431:Tb10.6k15.3160 ^@ http://purl.uniprot.org/uniprot/Q38AL4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/185431:Tb10.70.5820 ^@ http://purl.uniprot.org/uniprot/Q38C42 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/185431:Tb927.7.5540 ^@ http://purl.uniprot.org/uniprot/Q582G9 ^@ Similarity ^@ In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family. http://togogenome.org/gene/185431:Tb927.5.890 ^@ http://purl.uniprot.org/uniprot/Q57W34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/185431:Tb927.5.2860 ^@ http://purl.uniprot.org/uniprot/Q57ZW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.570 ^@ http://purl.uniprot.org/uniprot/Q57TZ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/185431:Tb927.5.3680 ^@ http://purl.uniprot.org/uniprot/Q57U98 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/185431:Tb09.211.4330 ^@ http://purl.uniprot.org/uniprot/Q38D78 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/185431:Tb927.7.2310 ^@ http://purl.uniprot.org/uniprot/Q57XP3 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/185431:Tb927.8.6170 ^@ http://purl.uniprot.org/uniprot/Q57YL8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/185431:Tb927.5.130 ^@ http://purl.uniprot.org/uniprot/Q57XG9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.3900 ^@ http://purl.uniprot.org/uniprot/Q57UM0 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation. The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen. PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase. VTC1 contributes only 3 transmembrane domains to the complex. The VTC complex also plays a role in vacuolar membrane fusion.|||Acidocalcisome membrane|||Belongs to the VTC1 family.|||Causes an abnormal morphology of acidocalcisomes, a significant decrease in the amount of polyP and a deficient response to hyposmotic stress.|||The VTC core complex is an integral membrane heterooligomer composed of at least the catalytic subunit vtc4 and the accessory subunits vtc1 and vtc2. vtc1 is a small membrane protein without hydrophilic domain. Vtc2 and vtc4 are related and have 2 hydrophilic domains that face the cytosol, an N-terminal SPX domain and the central core domain. The central core in vtc4 is the catalytic domain. http://togogenome.org/gene/185431:Tb927.8.800 ^@ http://purl.uniprot.org/uniprot/Q57YF1 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/185431:Tb927.3.1780 ^@ http://purl.uniprot.org/uniprot/D6XD86 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/185431:Tb927.3.1310 ^@ http://purl.uniprot.org/uniprot/Q57XW4 ^@ Similarity ^@ Belongs to the WD repeat mio family. http://togogenome.org/gene/185431:Tb10.6k15.1090 ^@ http://purl.uniprot.org/uniprot/Q38A43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.211.0470 ^@ http://purl.uniprot.org/uniprot/Q38EB2 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/185431:Tb09.160.0110 ^@ http://purl.uniprot.org/uniprot/Q38G20 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.980 ^@ http://purl.uniprot.org/uniprot/Q580C6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/185431:Tb10.70.0570 ^@ http://purl.uniprot.org/uniprot/Q38AY0 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/185431:Tb927.5.4560 ^@ http://purl.uniprot.org/uniprot/Q57X48 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/185431:Tb927.7.5960 ^@ http://purl.uniprot.org/uniprot/Q57VL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.211.4550 ^@ http://purl.uniprot.org/uniprot/Q38D53 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/185431:Tb927.6.2460 ^@ http://purl.uniprot.org/uniprot/Q584R0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb927.4.660 ^@ http://purl.uniprot.org/uniprot/Q57ZZ4 ^@ Similarity ^@ Belongs to the DNAI7 family. http://togogenome.org/gene/185431:Tb927.6.1330 ^@ http://purl.uniprot.org/uniprot/Q585B4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.6.3280 ^@ http://purl.uniprot.org/uniprot/Q584X1 ^@ Similarity ^@ Belongs to the APC1 family. http://togogenome.org/gene/185431:Tb927.8.630 ^@ http://purl.uniprot.org/uniprot/Q57YG7 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/185431:Tb09.211.4840 ^@ http://purl.uniprot.org/uniprot/Q38D26 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/185431:Tb927.6.1820 ^@ http://purl.uniprot.org/uniprot/Q585M9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.3.2870 ^@ http://purl.uniprot.org/uniprot/Q57ZM5 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/185431:Tb927.5.3600 ^@ http://purl.uniprot.org/uniprot/Q57UA6 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. http://togogenome.org/gene/185431:Tb927.7.5060 ^@ http://purl.uniprot.org/uniprot/Q57ZI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Membrane http://togogenome.org/gene/185431:Tb927.5.810 ^@ http://purl.uniprot.org/uniprot/Q57W26 ^@ Developmental Stage|||Disruption Phenotype|||Domain|||Function|||Induction|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Expressed in the procyclic form and the bloodstream form at low levels.|||Induced during the response to misfolded or unfolded cytoplasmic proteins; including during thermal stress, sodium arsenite, or acidic pH (at protein level) (PubMed:23592996, PubMed:27002830). Not induced by endoplasmic reticulum stress (PubMed:27002830).|||Interacts (via MKT1-binding motif) with MKT1 (PubMed:23592996, PubMed:24470144). Interacts with PBP1 (via C-terminus); the interaction is direct (PubMed:23592996, PubMed:24470144).|||Phosphorylated at the N-terminus (PubMed:23592996, PubMed:27002830). CK1.2-dependent phosphorylation may lead to proteasome-dependent degradation of ZC3H11 in absence of stress (PubMed:27002830).|||RNA-binding protein involved in regulation of mRNA stability (PubMed:23592996). Binds AU-rich regions in the 3'-UTR of mRNAs and promotes their stabilization by recruiting a MKT1-containing complex (PubMed:23592996, PubMed:24470144). Stabilizes chaperone mRNAs during stress that causes an accumulation of misfolded or unfolded proteins in the cytoplasm (PubMed:23592996, PubMed:24470144, PubMed:27002830).|||RNAi-mediated knockdown in the bloodstream form is lethal and causes a reduction in chaperone mRNA levels in response to heat-induced stress (PubMed:23592996). RNAi-mediated knockdown in the procyclic form causes sensitivity to cytoplasmic protein folding stress (induced by high temperature, puromycin, arsenite, MG132 or ethanol), characterized by a reduction in chaperone mRNA levels (PubMed:23592996, PubMed:27002830).|||The zinc finger domain binds AU-rich regions in the 3'-UTR of mRNAs. http://togogenome.org/gene/185431:Tb927.7.6310 ^@ http://purl.uniprot.org/uniprot/Q57VI0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/185431:Tb927.4.3680 ^@ http://purl.uniprot.org/uniprot/Q585I2 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/185431:Tb09.211.4512 ^@ http://purl.uniprot.org/uniprot/Q38D58 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KMP-11 family.|||Monomer.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.8.5810 ^@ http://purl.uniprot.org/uniprot/Q57YI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.7.4490 ^@ http://purl.uniprot.org/uniprot/Q57X65 ^@ Similarity ^@ Belongs to the SEC5 family. http://togogenome.org/gene/185431:Tb927.8.2910 ^@ http://purl.uniprot.org/uniprot/Q57W82 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/185431:Tb10.70.0850 ^@ http://purl.uniprot.org/uniprot/Q38B02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. http://togogenome.org/gene/185431:Tb10.70.3280 ^@ http://purl.uniprot.org/uniprot/Q38BK0 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/185431:Tb927.8.5600 ^@ http://purl.uniprot.org/uniprot/Q57X22 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/185431:Tb09.244.2850 ^@ http://purl.uniprot.org/uniprot/Q38D00 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb927.8.3980 ^@ http://purl.uniprot.org/uniprot/Q581B8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.2.4840 ^@ http://purl.uniprot.org/uniprot/Q586S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.8.5030 ^@ http://purl.uniprot.org/uniprot/Q57UH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/185431:Tb10.70.7240 ^@ http://purl.uniprot.org/uniprot/Q38CE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of genome stability.|||Monomer.|||Nucleus http://togogenome.org/gene/185431:Tb10.61.0610 ^@ http://purl.uniprot.org/uniprot/Q387U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.7.5930 ^@ http://purl.uniprot.org/uniprot/Q582K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.6000 ^@ http://purl.uniprot.org/uniprot/Q57VL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.3.950 ^@ http://purl.uniprot.org/uniprot/Q57WX8 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb927.5.4270 ^@ http://purl.uniprot.org/uniprot/Q57Z22 ^@ Domain|||Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. http://togogenome.org/gene/185431:Tb10.05.0150 ^@ http://purl.uniprot.org/uniprot/Q388Q5 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/185431:Tb927.4.4350 ^@ http://purl.uniprot.org/uniprot/Q57Y39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/185431:Tb927.3.5620 ^@ http://purl.uniprot.org/uniprot/Q580R3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/185431:Tb927.3.1840 ^@ http://purl.uniprot.org/uniprot/Q57ZC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/185431:Tb09.v1.0320 ^@ http://purl.uniprot.org/uniprot/Q38EK6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.1560 ^@ http://purl.uniprot.org/uniprot/Q38B58 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/185431:Tb927.7.1720 ^@ http://purl.uniprot.org/uniprot/Q57V38 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/185431:Tb10.26.0190 ^@ http://purl.uniprot.org/uniprot/Q389H0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb09.211.1760 ^@ http://purl.uniprot.org/uniprot/Q38DX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Polyamine:cation symporter (PHS) (TC 2.A.3.12) family.|||Membrane http://togogenome.org/gene/185431:Tb927.5.2320 ^@ http://purl.uniprot.org/uniprot/Q582D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAK10 family.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.8.1750 ^@ http://purl.uniprot.org/uniprot/D6XKR2|||http://purl.uniprot.org/uniprot/Q582A7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase (PubMed:25040552). Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity).|||Cytoplasm|||Mitochondrion intermembrane space|||Monomer.|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/185431:Tb927.4.4440 ^@ http://purl.uniprot.org/uniprot/Q583C9 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb09.160.3590 ^@ http://purl.uniprot.org/uniprot/Q38F46 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/185431:Tb927.7.4170 ^@ http://purl.uniprot.org/uniprot/Q57UP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.1690 ^@ http://purl.uniprot.org/uniprot/Q38B67 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/185431:Tb927.2.5410 ^@ http://purl.uniprot.org/uniprot/Q586E5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.6k15.2890 ^@ http://purl.uniprot.org/uniprot/Q38AJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/185431:Tb927.8.6090 ^@ http://purl.uniprot.org/uniprot/Q57YL0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/185431:Tb927.4.4740 ^@ http://purl.uniprot.org/uniprot/Q583F9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.211.0930 ^@ http://purl.uniprot.org/uniprot/Q38E63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/185431:Tb10.389.1870 ^@ http://purl.uniprot.org/uniprot/Q389F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/185431:TB927.1.2370 ^@ http://purl.uniprot.org/uniprot/Q4GYY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/185431:Tb09.160.1250 ^@ http://purl.uniprot.org/uniprot/Q38FR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Nucleus http://togogenome.org/gene/185431:Tb927.8.1160 ^@ http://purl.uniprot.org/uniprot/Q57VN8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/185431:Tb927.6.3650 ^@ http://purl.uniprot.org/uniprot/Q585W3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/185431:Tb10.61.0700 ^@ http://purl.uniprot.org/uniprot/Q387V0 ^@ Similarity ^@ Belongs to the WD repeat LST8 family. http://togogenome.org/gene/185431:Tb927.6.4090 ^@ http://purl.uniprot.org/uniprot/Q586A7 ^@ Function|||Similarity ^@ Belongs to the chaperonin (HSP60) family.|||Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. http://togogenome.org/gene/185431:Tb09.211.0110 ^@ http://purl.uniprot.org/uniprot/Q38EC5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/185431:Tb927.2.1890 ^@ http://purl.uniprot.org/uniprot/Q586I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.7.7040 ^@ http://purl.uniprot.org/uniprot/Q57XS4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/185431:Tb10.61.1920 ^@ http://purl.uniprot.org/uniprot/Q388C9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/185431:Tb927.4.1790 ^@ http://purl.uniprot.org/uniprot/Q581Q2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/185431:Tb10.61.3060 ^@ http://purl.uniprot.org/uniprot/Q388L3 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/185431:Tb927.6.4220 ^@ http://purl.uniprot.org/uniprot/Q586Y9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb10.6k15.0170 ^@ http://purl.uniprot.org/uniprot/Q389W6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/185431:Tb10.6k15.3170 ^@ http://purl.uniprot.org/uniprot/Q38AL5 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/185431:Tb09.160.0970 ^@ http://purl.uniprot.org/uniprot/Q38FU0 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/185431:Tb927.4.5580 ^@ http://purl.uniprot.org/uniprot/Q580N9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.2290 ^@ http://purl.uniprot.org/uniprot/Q584F8 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/185431:Tb927.4.2110 ^@ http://purl.uniprot.org/uniprot/Q583I2 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/185431:Tb927.6.5000 ^@ http://purl.uniprot.org/uniprot/Q586H2 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/185431:Tb10.61.0770 ^@ http://purl.uniprot.org/uniprot/Q387V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/185431:TB927.1.2100 ^@ http://purl.uniprot.org/uniprot/Q4GZ11 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb09.160.3850 ^@ http://purl.uniprot.org/uniprot/Q38F20 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/185431:Tb10.61.2610 ^@ http://purl.uniprot.org/uniprot/Q388I2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/185431:Tb10.6k15.2720 ^@ http://purl.uniprot.org/uniprot/Q38AH9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/185431:Tb09.211.0630 ^@ http://purl.uniprot.org/uniprot/Q38E94 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/185431:Tb927.7.4830 ^@ http://purl.uniprot.org/uniprot/Q57X99 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.3.2190 ^@ http://purl.uniprot.org/uniprot/Q582T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fungal TPase family.|||Nucleus http://togogenome.org/gene/185431:Tb927.2.6090 ^@ http://purl.uniprot.org/uniprot/D7SG81 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/185431:Tb09.244.2240 ^@ http://purl.uniprot.org/uniprot/Q38CT8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.5.3760 ^@ http://purl.uniprot.org/uniprot/Q57U90 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/185431:Tb09.211.2970 ^@ http://purl.uniprot.org/uniprot/Q38DK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Nucleus http://togogenome.org/gene/185431:Tb09.211.4850 ^@ http://purl.uniprot.org/uniprot/Q38D25 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/185431:Tb927.7.5990 ^@ http://purl.uniprot.org/uniprot/Q57VL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.2.2670 ^@ http://purl.uniprot.org/uniprot/Q587H6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.70.7260 ^@ http://purl.uniprot.org/uniprot/Q38CF1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.4.460 ^@ http://purl.uniprot.org/uniprot/Q57US9 ^@ Cofactor ^@ Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/185431:Tb927.2.4550 ^@ http://purl.uniprot.org/uniprot/Q586Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.|||nucleolus http://togogenome.org/gene/185431:Tb927.7.1060 ^@ http://purl.uniprot.org/uniprot/Q57VV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.4.430 ^@ http://purl.uniprot.org/uniprot/D6XEX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/185431:Tb09.160.5350 ^@ http://purl.uniprot.org/uniprot/Q38EL6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.2.2950 ^@ http://purl.uniprot.org/uniprot/Q587G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/185431:Tb927.7.2190 ^@ http://purl.uniprot.org/uniprot/Q57XQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.5.2410 ^@ http://purl.uniprot.org/uniprot/Q582C4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Ungrouped subfamily. http://togogenome.org/gene/185431:Tb10.6k15.3080 ^@ http://purl.uniprot.org/uniprot/Q38AK7 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/185431:Tb10.389.0910 ^@ http://purl.uniprot.org/uniprot/Q388X5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/185431:Tb927.7.3840 ^@ http://purl.uniprot.org/uniprot/D6XIR5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.8.4640 ^@ http://purl.uniprot.org/uniprot/Q57UY7 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/185431:Tb10.389.0510 ^@ http://purl.uniprot.org/uniprot/Q388U6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/185431:Tb10.389.0270 ^@ http://purl.uniprot.org/uniprot/Q388S8 ^@ Similarity ^@ Belongs to the WD repeat ARPC1 family. http://togogenome.org/gene/185431:Tb927.4.3300 ^@ http://purl.uniprot.org/uniprot/Q584A7 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb927.8.4440 ^@ http://purl.uniprot.org/uniprot/Q57VZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.3030 ^@ http://purl.uniprot.org/uniprot/Q38DK3 ^@ Similarity ^@ Belongs to the peroxidase family. http://togogenome.org/gene/185431:Tb10.70.7020 ^@ http://purl.uniprot.org/uniprot/Q38CD1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/185431:Tb927.8.5210 ^@ http://purl.uniprot.org/uniprot/Q57UJ3 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/185431:Tb927.4.1330 ^@ http://purl.uniprot.org/uniprot/Q581U8 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/185431:Tb927.2.2430 ^@ http://purl.uniprot.org/uniprot/Q586L5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.6.760 ^@ http://purl.uniprot.org/uniprot/Q583S7 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.26.1080 ^@ http://purl.uniprot.org/uniprot/Q389P1 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/185431:Tb927.2.4980 ^@ http://purl.uniprot.org/uniprot/Q586T6 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/185431:Tb09.211.4990 ^@ http://purl.uniprot.org/uniprot/Q38D10 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb10.70.5920 ^@ http://purl.uniprot.org/uniprot/Q38C51 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.70.5670 ^@ http://purl.uniprot.org/uniprot/P86934|||http://purl.uniprot.org/uniprot/P86939 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Phosphatidylethanolamine (PE) is a direct precursor of the ethanolamine-phosphoglycerol (EPG) moiety.|||The Kennedy pathway is the major route for phosphatidylethanolamine (PE) synthesis, as shown by reduced levels after using RNAi against the first two enzymes of the Kennedy pathway.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/185431:Tb927.6.5110 ^@ http://purl.uniprot.org/uniprot/Q586I3 ^@ Similarity ^@ Belongs to the DDB1 family. http://togogenome.org/gene/185431:Tb927.3.4760 ^@ http://purl.uniprot.org/uniprot/Q582Q9 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/185431:Tb927.2.1760 ^@ http://purl.uniprot.org/uniprot/Q585S4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb09.211.4290 ^@ http://purl.uniprot.org/uniprot/Q38D81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.6880 ^@ http://purl.uniprot.org/uniprot/Q38CB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.8.7860 ^@ http://purl.uniprot.org/uniprot/Q57U57 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.6k15.2410 ^@ http://purl.uniprot.org/uniprot/Q38AF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.2.5910 ^@ http://purl.uniprot.org/uniprot/Q586C2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/185431:Tb10.70.2980 ^@ http://purl.uniprot.org/uniprot/Q38BH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/185431:Tb927.3.1920 ^@ http://purl.uniprot.org/uniprot/Q57ZB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT2/3/5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb10.70.2465 ^@ http://purl.uniprot.org/uniprot/Q38BC7 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/185431:Tb10.406.0470 ^@ http://purl.uniprot.org/uniprot/Q389T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.8.3290 ^@ http://purl.uniprot.org/uniprot/Q57YY4 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/185431:Tb10.26.0570 ^@ http://purl.uniprot.org/uniprot/Q389K2 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/185431:Tb927.7.2520 ^@ http://purl.uniprot.org/uniprot/Q57XM2 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/185431:Tb927.7.7060 ^@ http://purl.uniprot.org/uniprot/Q57XS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/185431:Tb927.2.2460 ^@ http://purl.uniprot.org/uniprot/Q586L8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/185431:Tb927.6.4520 ^@ http://purl.uniprot.org/uniprot/Q587B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MNS1 family.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.0040 ^@ http://purl.uniprot.org/uniprot/Q38AT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/185431:Tb927.7.410 ^@ http://purl.uniprot.org/uniprot/Q57U13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.6.2100 ^@ http://purl.uniprot.org/uniprot/Q584U6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS30 family. http://togogenome.org/gene/185431:Tb927.6.510 ^@ http://purl.uniprot.org/uniprot/Q581F9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Major surface antigen of procyclic forms.|||Membrane http://togogenome.org/gene/185431:Tb927.3.1130 ^@ http://purl.uniprot.org/uniprot/Q57WZ4 ^@ Similarity ^@ Belongs to the DNA polymerase delta/II small subunit family. http://togogenome.org/gene/185431:TB927.1.1560 ^@ http://purl.uniprot.org/uniprot/Q4GZ63 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/185431:Tb10.100.0150 ^@ http://purl.uniprot.org/uniprot/Q38CL2 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/185431:TB927.1.2350 ^@ http://purl.uniprot.org/uniprot/Q4GYY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/185431:Tb927.4.3610 ^@ http://purl.uniprot.org/uniprot/Q585I9 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb927.5.840 ^@ http://purl.uniprot.org/uniprot/Q57W29 ^@ Similarity ^@ Belongs to the KRI1 family. http://togogenome.org/gene/185431:Tb10.26.0860 ^@ http://purl.uniprot.org/uniprot/Q389M3 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/185431:Tb927.4.2230 ^@ http://purl.uniprot.org/uniprot/Q584G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/185431:Tb927.8.3630 ^@ http://purl.uniprot.org/uniprot/Q580Y3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.5.4380 ^@ http://purl.uniprot.org/uniprot/Q57Z11 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb927.5.800 ^@ http://purl.uniprot.org/uniprot/Q57W25 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb09.211.3110 ^@ http://purl.uniprot.org/uniprot/Q38DJ5 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/185431:TB927.1.5330 ^@ http://purl.uniprot.org/uniprot/Q4GY50 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.6.4540 ^@ http://purl.uniprot.org/uniprot/Q587C0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb10.389.1550 ^@ http://purl.uniprot.org/uniprot/Q389C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/185431:Tb927.7.1680 ^@ http://purl.uniprot.org/uniprot/Q57V42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/185431:Tb10.70.0630 ^@ http://purl.uniprot.org/uniprot/Q38AY7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/185431:Tb10.70.4940 ^@ http://purl.uniprot.org/uniprot/Q38BX3 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/185431:Tb927.7.4330 ^@ http://purl.uniprot.org/uniprot/Q57UR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||cilium basal body http://togogenome.org/gene/185431:Tb10.100.0070 ^@ http://purl.uniprot.org/uniprot/Q38CM0 ^@ Similarity ^@ Belongs to the ATPase gamma chain family. http://togogenome.org/gene/185431:Tb927.3.4900 ^@ http://purl.uniprot.org/uniprot/Q582P5 ^@ Similarity ^@ Belongs to the IPP transferase family. http://togogenome.org/gene/185431:TB927.1.1980 ^@ http://purl.uniprot.org/uniprot/Q4GZ21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/185431:Tb10.389.0530 ^@ http://purl.uniprot.org/uniprot/Q388U8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/185431:Tb927.7.220 ^@ http://purl.uniprot.org/uniprot/Q57U32 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/185431:Tb927.7.6150 ^@ http://purl.uniprot.org/uniprot/Q57VJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/185431:Tb927.5.4410 ^@ http://purl.uniprot.org/uniprot/Q57Z08 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/185431:Tb927.6.800 ^@ http://purl.uniprot.org/uniprot/Q583S3 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.7.5170 ^@ http://purl.uniprot.org/uniprot/Q57ZH2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/185431:Tb927.7.6280 ^@ http://purl.uniprot.org/uniprot/Q57VI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme http://togogenome.org/gene/185431:Tb927.6.2050 ^@ http://purl.uniprot.org/uniprot/Q584V1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/185431:Tb10.6k15.1350 ^@ http://purl.uniprot.org/uniprot/Q38A66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.|||Membrane http://togogenome.org/gene/185431:Tb927.4.3600 ^@ http://purl.uniprot.org/uniprot/Q585J0 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/185431:Tb10.61.1880 ^@ http://purl.uniprot.org/uniprot/Q388C6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb10.70.7090 ^@ http://purl.uniprot.org/uniprot/Q38CD6 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/185431:Tb10.70.7480 ^@ http://purl.uniprot.org/uniprot/Q38CG7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/185431:Tb09.244.0910 ^@ http://purl.uniprot.org/uniprot/Q38CP5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.2380 ^@ http://purl.uniprot.org/uniprot/Q57XF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.160.2540 ^@ http://purl.uniprot.org/uniprot/Q38FD5 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/185431:Tb927.2.4580 ^@ http://purl.uniprot.org/uniprot/Q586Q9 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/185431:Tb927.5.3350 ^@ http://purl.uniprot.org/uniprot/Q57Z58 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/185431:Tb10.61.2930 ^@ http://purl.uniprot.org/uniprot/Q388K4 ^@ Similarity ^@ Belongs to the TBCB family. http://togogenome.org/gene/185431:Tb927.3.180 ^@ http://purl.uniprot.org/uniprot/Q57TR9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.5280 ^@ http://purl.uniprot.org/uniprot/Q584H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.2.5020 ^@ http://purl.uniprot.org/uniprot/Q586U0 ^@ Similarity ^@ Belongs to the acyl-CoA oxidase family. http://togogenome.org/gene/185431:Tb927.8.2560 ^@ http://purl.uniprot.org/uniprot/Q57XD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.3.4630 ^@ http://purl.uniprot.org/uniprot/Q582S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/185431:Tb927.5.3750 ^@ http://purl.uniprot.org/uniprot/Q57U91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.2.5060 ^@ http://purl.uniprot.org/uniprot/Q586U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer. http://togogenome.org/gene/185431:Tb927.6.3050 ^@ http://purl.uniprot.org/uniprot/Q583M9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/185431:Tb10.6k15.0530 ^@ http://purl.uniprot.org/uniprot/Q389Z8 ^@ Domain|||Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. http://togogenome.org/gene/185431:Tb10.61.2650 ^@ http://purl.uniprot.org/uniprot/Q388I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/185431:Tb927.7.2340 ^@ http://purl.uniprot.org/uniprot/Q57XN7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/185431:Tb10.61.2750 ^@ http://purl.uniprot.org/uniprot/Q388P0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.160.5250 ^@ http://purl.uniprot.org/uniprot/Q38EM6 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/185431:Tb927.7.1930 ^@ http://purl.uniprot.org/uniprot/Q57V17 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/185431:Tb10.406.0430 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.8.5770 ^@ http://purl.uniprot.org/uniprot/Q57X05 ^@ Similarity ^@ Belongs to the ELP3 family. http://togogenome.org/gene/185431:Tb927.8.3370 ^@ http://purl.uniprot.org/uniprot/Q57YX6 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/185431:Tb927.4.800 ^@ http://purl.uniprot.org/uniprot/Q580A8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/185431:Tb927.7.3600 ^@ http://purl.uniprot.org/uniprot/Q57WH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/185431:Tb927.7.5360 ^@ http://purl.uniprot.org/uniprot/Q57ZF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.6k15.2020 ^@ http://purl.uniprot.org/uniprot/Q38AB8 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/185431:Tb927.3.780 ^@ http://purl.uniprot.org/uniprot/D6XCY8 ^@ Similarity ^@ Belongs to the peptidase T1A family. http://togogenome.org/gene/185431:Tb927.3.620 ^@ http://purl.uniprot.org/uniprot/Q57WU5 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/185431:Tb927.7.5760 ^@ http://purl.uniprot.org/uniprot/Q582J1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/185431:TB927.1.2490 ^@ http://purl.uniprot.org/uniprot/Q4GYX7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/185431:Tb927.7.6260 ^@ http://purl.uniprot.org/uniprot/Q57VI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/185431:Tb927.4.5700 ^@ http://purl.uniprot.org/uniprot/Q580N8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.6.5130 ^@ http://purl.uniprot.org/uniprot/Q586I4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||P1 and P2 exist as dimers at the large ribosomal subunit.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/185431:Tb927.4.5790 ^@ http://purl.uniprot.org/uniprot/Q580N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:TB927.1.1580 ^@ http://purl.uniprot.org/uniprot/Q4GZ61 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/185431:Tb10.70.2470 ^@ http://purl.uniprot.org/uniprot/Q38BC8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/185431:Tb10.389.0470 ^@ http://purl.uniprot.org/uniprot/Q388U3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.5.1450 ^@ http://purl.uniprot.org/uniprot/Q57VB8 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.3.3590 ^@ http://purl.uniprot.org/uniprot/Q57W95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||nucleolus http://togogenome.org/gene/185431:Tb09.211.0870 ^@ http://purl.uniprot.org/uniprot/Q38E68 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/185431:Tb10.70.6950 ^@ http://purl.uniprot.org/uniprot/Q4FKF8 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/185431:Tb927.5.910 ^@ http://purl.uniprot.org/uniprot/Q57W36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.5050 ^@ http://purl.uniprot.org/uniprot/Q38BY3 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/185431:Tb927.7.370 ^@ http://purl.uniprot.org/uniprot/Q57U17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb09.244.2790 ^@ http://purl.uniprot.org/uniprot/Q38CZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||nucleolus http://togogenome.org/gene/185431:Tb927.7.5790 ^@ http://purl.uniprot.org/uniprot/Q582J4 ^@ Similarity ^@ Belongs to the protein disulfide isomerase family. http://togogenome.org/gene/185431:Tb927.6.1610 ^@ http://purl.uniprot.org/uniprot/Q585P9 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.8.7590 ^@ http://purl.uniprot.org/uniprot/Q57V80 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.70.7100 ^@ http://purl.uniprot.org/uniprot/Q38CD7 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/185431:Tb927.3.5550 ^@ http://purl.uniprot.org/uniprot/Q580S0 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rab family.|||Component of the IFT complex B.|||Expressed during procyclic stages.|||Small GTPase-like component of the intraflagellar transport (IFT) complex B required for both anterograde and retrograde intraflagellar transport. May be involved in cargo loading of the retrograde transport.|||flagellum http://togogenome.org/gene/185431:Tb10.61.1790 ^@ http://purl.uniprot.org/uniprot/Q388C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I LYR family.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.6.3160 ^@ http://purl.uniprot.org/uniprot/Q584V9 ^@ Similarity ^@ Belongs to the SF3A3 family. http://togogenome.org/gene/185431:Tb927.6.560 ^@ http://purl.uniprot.org/uniprot/D6XHE1 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb927.5.520 ^@ http://purl.uniprot.org/uniprot/Q57VW1 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/185431:Tb09.244.2590 ^@ http://purl.uniprot.org/uniprot/Q38CW9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/185431:Tb927.4.4450 ^@ http://purl.uniprot.org/uniprot/Q583D0 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.3.5660 ^@ http://purl.uniprot.org/uniprot/Q57VH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.8.8350 ^@ http://purl.uniprot.org/uniprot/Q57WJ5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.8.1810 ^@ http://purl.uniprot.org/uniprot/Q582A1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:TB927.1.1680 ^@ http://purl.uniprot.org/uniprot/Q4GZ51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/185431:Tb927.8.6020 ^@ http://purl.uniprot.org/uniprot/Q57YK3 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/185431:Tb927.2.5240 ^@ http://purl.uniprot.org/uniprot/Q585U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Nucleus|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. http://togogenome.org/gene/185431:Tb927.8.3620 ^@ http://purl.uniprot.org/uniprot/Q580Y2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.8.2870 ^@ http://purl.uniprot.org/uniprot/Q57W85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP162 family.|||centriole http://togogenome.org/gene/185431:Tb927.7.2940 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.6k15.2050 ^@ http://purl.uniprot.org/uniprot/Q38AC1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/185431:Tb927.7.4930 ^@ http://purl.uniprot.org/uniprot/Q57XA9 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/185431:Tb927.5.880 ^@ http://purl.uniprot.org/uniprot/Q57W33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/185431:Tb10.406.0500 ^@ http://purl.uniprot.org/uniprot/Q389T6 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/185431:Tb927.3.570 ^@ http://purl.uniprot.org/uniprot/Q57TQ9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.244.2720 ^@ http://purl.uniprot.org/uniprot/Q38CY7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/185431:Tb927.4.4320 ^@ http://purl.uniprot.org/uniprot/Q57Y36 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/185431:Tb927.8.7870 ^@ http://purl.uniprot.org/uniprot/Q57U56 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.70.6540 ^@ http://purl.uniprot.org/uniprot/Q38C93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.3.3860 ^@ http://purl.uniprot.org/uniprot/Q57WC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.4.1340 ^@ http://purl.uniprot.org/uniprot/Q581U7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.8.7110 ^@ http://purl.uniprot.org/uniprot/Q57YR8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb09.160.5240 ^@ http://purl.uniprot.org/uniprot/Q38EM7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/185431:TB927.1.710 ^@ http://purl.uniprot.org/uniprot/Q4GZG3 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/185431:Tb927.2.5190 ^@ http://purl.uniprot.org/uniprot/Q585V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.5.1880 ^@ http://purl.uniprot.org/uniprot/D6XGC6|||http://purl.uniprot.org/uniprot/Q57ZQ7 ^@ Similarity ^@ Belongs to the protease inhibitor I11 (ecotin) family. http://togogenome.org/gene/185431:TB927.1.1120 ^@ http://purl.uniprot.org/uniprot/Q4GZA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||Probable methyltransferase required to silence rDNA.|||nucleolus http://togogenome.org/gene/185431:Tb10.70.3680 ^@ http://purl.uniprot.org/uniprot/Q38BN0 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.6.1280 ^@ http://purl.uniprot.org/uniprot/Q585B9 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/185431:Tb10.70.0010 ^@ http://purl.uniprot.org/uniprot/Q38AT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/185431:Tb927.4.760 ^@ http://purl.uniprot.org/uniprot/Q580A4 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/185431:Tb09.211.4610 ^@ http://purl.uniprot.org/uniprot/Q38D47 ^@ Similarity ^@ Belongs to the synaptobrevin family. http://togogenome.org/gene/185431:Tb927.5.1820 ^@ http://purl.uniprot.org/uniprot/Q57ZQ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||P1 and P2 exist as dimers at the large ribosomal subunit.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/185431:Tb10.6k15.2610 ^@ http://purl.uniprot.org/uniprot/Q38AH0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of a complex composed of CBF5, GAR1, NHP2, MTR1, NOP10 and Tb11.01.8210.|||Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of spliced leader and U1 small nuclear RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped RNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. Recognizes a guanosine cap on RNA independent of its N(7) methylation status. http://togogenome.org/gene/185431:Tb10.61.2510 ^@ http://purl.uniprot.org/uniprot/Q388H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.3060 ^@ http://purl.uniprot.org/uniprot/Q57W67 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/185431:Tb927.4.4410 ^@ http://purl.uniprot.org/uniprot/D6XEJ9 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.8.3330 ^@ http://purl.uniprot.org/uniprot/Q57YY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.7930 ^@ http://purl.uniprot.org/uniprot/Q57U52 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.4.4250 ^@ http://purl.uniprot.org/uniprot/Q57Y29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.7.2830 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.6.2700 ^@ http://purl.uniprot.org/uniprot/D6XI03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/185431:Tb927.8.4280 ^@ http://purl.uniprot.org/uniprot/Q57W07 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/185431:Tb927.3.1110 ^@ http://purl.uniprot.org/uniprot/Q57WZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/185431:Tb10.70.5130 ^@ http://purl.uniprot.org/uniprot/Q38BZ1 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/185431:Tb10.61.1960 ^@ http://purl.uniprot.org/uniprot/Q388D3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/185431:Tb927.6.600 ^@ http://purl.uniprot.org/uniprot/Q583U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/185431:TB927.1.1130 ^@ http://purl.uniprot.org/uniprot/Q4GZA5 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/185431:Tb927.7.5020 ^@ http://purl.uniprot.org/uniprot/Q57ZI7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL19 family. http://togogenome.org/gene/185431:Tb927.2.1680 ^@ http://purl.uniprot.org/uniprot/Q585R9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb09.211.2300 ^@ http://purl.uniprot.org/uniprot/Q38DS7 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/185431:Tb927.4.2630 ^@ http://purl.uniprot.org/uniprot/Q584C4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.|||nucleolus http://togogenome.org/gene/185431:Tb927.7.3860 ^@ http://purl.uniprot.org/uniprot/Q57UD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane http://togogenome.org/gene/185431:Tb10.6k15.2790 ^@ http://purl.uniprot.org/uniprot/Q38AI6 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/185431:Tb927.8.2610 ^@ http://purl.uniprot.org/uniprot/Q57XC8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/185431:Tb927.2.6280 ^@ http://purl.uniprot.org/uniprot/Q586M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:Tb10.406.0110 ^@ http://purl.uniprot.org/uniprot/Q389Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAP2/GCS1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/185431:TB927.1.870 ^@ http://purl.uniprot.org/uniprot/Q4GZD1 ^@ Caution|||Disruption Phenotype|||Function|||Similarity|||Subunit ^@ Belongs to the deoxyhypusine synthase family.|||Heterotetramer formed by a homodimer of the non-catalytic regulatory subunit DHSp and a homodimer of the catalytic subunit DHSc where DHSc appears to bind spermidine and DHSp appears to bind NAD(+).|||Lacks the conserved active site Lys, and therefore lacks catalytic activity.|||RNAi-mediated knockdown causes cell growth arrest followed by death, loss of DHSp expression and a failure to sustain infection in mice.|||Required for the activation and stability of deoxyhypusine synthase DHSc. Required for cell growth and survival. http://togogenome.org/gene/185431:Tb09.244.2020 ^@ http://purl.uniprot.org/uniprot/Q38CR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:TB927.1.3300 ^@ http://purl.uniprot.org/uniprot/Q4GYP3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/185431:Tb927.8.5580 ^@ http://purl.uniprot.org/uniprot/Q57X24 ^@ Similarity ^@ Belongs to the VPS13 family. http://togogenome.org/gene/185431:Tb927.4.4470 ^@ http://purl.uniprot.org/uniprot/Q583D2 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:TB927.1.570 ^@ http://purl.uniprot.org/uniprot/Q4GZF2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus http://togogenome.org/gene/185431:Tb927.8.7980 ^@ http://purl.uniprot.org/uniprot/Q57U47 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.70.1880 ^@ http://purl.uniprot.org/uniprot/Q38B80 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/185431:Tb927.6.1970 ^@ http://purl.uniprot.org/uniprot/Q585L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NCBP2 family.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.6420 ^@ http://purl.uniprot.org/uniprot/Q38C89 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/185431:Tb10.70.0430 ^@ http://purl.uniprot.org/uniprot/Q38AV5 ^@ Function|||Similarity ^@ Belongs to the chaperonin (HSP60) family.|||Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. http://togogenome.org/gene/185431:Tb927.4.2880 ^@ http://purl.uniprot.org/uniprot/Q583W5 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/185431:Tb09.244.2630 ^@ http://purl.uniprot.org/uniprot/Q38CX3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/185431:Tb10.389.1180 ^@ http://purl.uniprot.org/uniprot/Q388Z3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.3.4650 ^@ http://purl.uniprot.org/uniprot/Q582S0 ^@ Similarity ^@ Belongs to the ERG2 family. http://togogenome.org/gene/185431:TB927.1.1140 ^@ http://purl.uniprot.org/uniprot/Q4GZA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/185431:Tb10.389.0730 ^@ http://purl.uniprot.org/uniprot/Q388W5 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/185431:Tb10.61.1710 ^@ http://purl.uniprot.org/uniprot/Q388B5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/185431:Tb927.8.2020 ^@ http://purl.uniprot.org/uniprot/Q581Y0 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/185431:Tb10.6k15.0970 ^@ http://purl.uniprot.org/uniprot/Q38A32 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/185431:Tb09.211.1695 ^@ http://purl.uniprot.org/uniprot/Q38DY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/185431:Tb927.4.1830 ^@ http://purl.uniprot.org/uniprot/Q583L0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.3.1540 ^@ http://purl.uniprot.org/uniprot/Q57XY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:TB927.1.5100 ^@ http://purl.uniprot.org/uniprot/Q4GY71 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.3280 ^@ http://purl.uniprot.org/uniprot/Q57WE3 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/185431:Tb927.4.1860 ^@ http://purl.uniprot.org/uniprot/Q583K7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/185431:Tb10.70.7550 ^@ http://purl.uniprot.org/uniprot/Q38CH4 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/185431:Tb927.8.6880 ^@ http://purl.uniprot.org/uniprot/Q57TS5 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. http://togogenome.org/gene/185431:Tb927.2.4850 ^@ http://purl.uniprot.org/uniprot/Q586S7 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/185431:Tb10.406.0350 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.6.1650 ^@ http://purl.uniprot.org/uniprot/Q585P5 ^@ Similarity ^@ Belongs to the nuclease type I family. http://togogenome.org/gene/185431:Tb10.70.5940 ^@ http://purl.uniprot.org/uniprot/Q38C52 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/185431:Tb927.8.6190 ^@ http://purl.uniprot.org/uniprot/Q57YM0 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/185431:TB927.1.1000 ^@ http://purl.uniprot.org/uniprot/Q4GZB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/185431:Tb10.70.0465 ^@ http://purl.uniprot.org/uniprot/Q38AW9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/185431:Tb927.7.6290 ^@ http://purl.uniprot.org/uniprot/Q57VI2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.3.1630 ^@ http://purl.uniprot.org/uniprot/Q57ZE8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb10.6k15.2500 ^@ http://purl.uniprot.org/uniprot/Q38AG0 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/185431:Tb927.7.5180 ^@ http://purl.uniprot.org/uniprot/Q57ZH1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/185431:Tb927.8.1930 ^@ http://purl.uniprot.org/uniprot/Q581Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.0720 ^@ http://purl.uniprot.org/uniprot/Q38AZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.3750 ^@ http://purl.uniprot.org/uniprot/Q580Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/185431:Tb927.6.4660 ^@ http://purl.uniprot.org/uniprot/D6XIJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.4.1070 ^@ http://purl.uniprot.org/uniprot/Q580D5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/185431:Tb09.160.3500 ^@ http://purl.uniprot.org/uniprot/Q38F55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.2130 ^@ http://purl.uniprot.org/uniprot/Q57UZ8 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/185431:Tb927.3.5030 ^@ http://purl.uniprot.org/uniprot/Q582N4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.5.4030 ^@ http://purl.uniprot.org/uniprot/D6XGY7 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/185431:Tb10.6k15.0360 ^@ http://purl.uniprot.org/uniprot/Q389Y4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/185431:Tb927.2.5660 ^@ http://purl.uniprot.org/uniprot/Q586D5 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/185431:Tb927.7.710 ^@ http://purl.uniprot.org/uniprot/Q57VR7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/185431:Tb09.211.1000 ^@ http://purl.uniprot.org/uniprot/Q38E56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target (By similarity).|||Golgi apparatus membrane http://togogenome.org/gene/185431:Tb927.6.3340 ^@ http://purl.uniprot.org/uniprot/Q584X7 ^@ Similarity ^@ Belongs to the CCDC25 family. http://togogenome.org/gene/185431:Tb927.5.4540 ^@ http://purl.uniprot.org/uniprot/Q57X50 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.6.3420 ^@ http://purl.uniprot.org/uniprot/Q584Y2 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/185431:Tb927.8.7900 ^@ http://purl.uniprot.org/uniprot/Q57U54 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.5.4210 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.8.7920 ^@ http://purl.uniprot.org/uniprot/Q57U53 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.2.3910 ^@ http://purl.uniprot.org/uniprot/Q586W9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/185431:Tb927.6.1010 ^@ http://purl.uniprot.org/uniprot/Q585F0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb10.26.0830 ^@ http://purl.uniprot.org/uniprot/Q389M0 ^@ Cofactor|||Similarity ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/185431:Tb927.8.6160 ^@ http://purl.uniprot.org/uniprot/Q57YL6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/185431:Tb09.160.4090 ^@ http://purl.uniprot.org/uniprot/Q38EZ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase family.|||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|||Homodimer. http://togogenome.org/gene/185431:Tb09.211.3550 ^@ http://purl.uniprot.org/uniprot/Q38DF2 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/185431:Tb927.7.5980 ^@ http://purl.uniprot.org/uniprot/Q57VL3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.160.2260 ^@ http://purl.uniprot.org/uniprot/Q38FG7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb10.70.7270 ^@ http://purl.uniprot.org/uniprot/Q38CF2 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/185431:Tb927.4.2350 ^@ http://purl.uniprot.org/uniprot/Q584F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.5.3810 ^@ http://purl.uniprot.org/uniprot/Q57U85 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. Type 2 subfamily. http://togogenome.org/gene/185431:Tb09.211.0775 ^@ http://purl.uniprot.org/uniprot/Q38E79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.3.1950 ^@ http://purl.uniprot.org/uniprot/Q57ZB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.2910 ^@ http://purl.uniprot.org/uniprot/Q38DL4 ^@ Similarity ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. http://togogenome.org/gene/185431:Tb927.3.490 ^@ http://purl.uniprot.org/uniprot/Q57TR3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.2070 ^@ http://purl.uniprot.org/uniprot/Q38B88 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/185431:Tb10.70.5340 ^@ http://purl.uniprot.org/uniprot/Q38C05 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.5.5050 ^@ http://purl.uniprot.org/uniprot/Q57XG5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.5950 ^@ http://purl.uniprot.org/uniprot/Q57VL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.160.0700 ^@ http://purl.uniprot.org/uniprot/Q38FW8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/185431:Tb927.5.2130 ^@ http://purl.uniprot.org/uniprot/Q57ZT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/185431:Tb10.6k15.0540 ^@ http://purl.uniprot.org/uniprot/Q389Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/185431:Tb927.4.2120 ^@ http://purl.uniprot.org/uniprot/Q584H5 ^@ Similarity ^@ Belongs to the WD repeat SEC13 family. http://togogenome.org/gene/185431:Tb10.6k15.1180 ^@ http://purl.uniprot.org/uniprot/Q38A51 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/185431:Tb10.61.2680 ^@ http://purl.uniprot.org/uniprot/Q388I8 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/185431:Tb09.160.1010 ^@ http://purl.uniprot.org/uniprot/Q38FT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.3.2540 ^@ http://purl.uniprot.org/uniprot/Q582W6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.160.1560 ^@ http://purl.uniprot.org/uniprot/Q38FN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/185431:Tb927.5.3970 ^@ http://purl.uniprot.org/uniprot/Q57U69 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/185431:Tb09.160.2970 ^@ http://purl.uniprot.org/uniprot/P86927 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA ligase 2 family.|||Component of the RNA editing complex (editosome), a 1600 kDa complex composed of at least 20 proteins (By similarity). Interacts with terminal uridylyltransferase MEAT1 (By similarity).|||Essential for RNA editing. RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs.|||Mitochondrion http://togogenome.org/gene/185431:Tb10.6k15.2460 ^@ http://purl.uniprot.org/uniprot/Q38AF7 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/185431:Tb927.6.3800 ^@ http://purl.uniprot.org/uniprot/Q585X3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/185431:Tb927.6.4740 ^@ http://purl.uniprot.org/uniprot/Q587E0 ^@ Similarity ^@ Belongs to the XPO2/CSE1 family. http://togogenome.org/gene/185431:Tb927.7.2670 ^@ http://purl.uniprot.org/uniprot/Q57Y77 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Induction ^@ Expressed in the procyclic form.|||Induced during the differentiation of the bloodstream form to the procyclic form.|||RNA-binding protein involved in regulation of mRNA stability (PubMed:31743541). Promotes mRNA stabilization by recruiting MKT1 and PBP1 (By similarity). Stabilizes transcripts encoding mitochondrial proteins (PubMed:31743541).|||RNAi-mediated knockdown in procyclic form does not affect growth rate (PubMed:31743541). Simultaneous knockdown of ZC3H20 and ZC3H21 in the procyclic form results in a severe population growth defect and a shift towards the bloodstream form transcriptome (PubMed:31743541). Simultaneous knockdown of ZC3H20 and ZC3H21 in the bloodstream form is lethal (PubMed:31743541). http://togogenome.org/gene/185431:Tb927.8.5060 ^@ http://purl.uniprot.org/uniprot/Q57UH8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/185431:Tb10.70.2760 ^@ http://purl.uniprot.org/uniprot/Q38BF5 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/185431:TB927.1.2470 ^@ http://purl.uniprot.org/uniprot/Q4GYX7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/185431:Tb927.5.2960 ^@ http://purl.uniprot.org/uniprot/Q57ZX2 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/185431:Tb927.7.4000 ^@ http://purl.uniprot.org/uniprot/Q57UN0 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/185431:Tb10.389.0480 ^@ http://purl.uniprot.org/uniprot/Q388U4 ^@ Similarity ^@ Belongs to the VPS16 family. http://togogenome.org/gene/185431:Tb927.7.1580 ^@ http://purl.uniprot.org/uniprot/Q57WP2 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/185431:Tb927.3.3840 ^@ http://purl.uniprot.org/uniprot/Q57WC0 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/185431:Tb927.3.3330 ^@ http://purl.uniprot.org/uniprot/Q57V53 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/185431:Tb10.6k15.2330 ^@ http://purl.uniprot.org/uniprot/Q38AE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. http://togogenome.org/gene/185431:Tb927.4.1690 ^@ http://purl.uniprot.org/uniprot/Q581R2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/185431:Tb927.8.460 ^@ http://purl.uniprot.org/uniprot/Q57XI6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.211.2440 ^@ http://purl.uniprot.org/uniprot/Q38DR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane http://togogenome.org/gene/185431:Tb927.7.6230 ^@ http://purl.uniprot.org/uniprot/Q57VI8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/185431:Tb927.8.4880 ^@ http://purl.uniprot.org/uniprot/Q57UW4 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/185431:Tb927.5.4430 ^@ http://purl.uniprot.org/uniprot/Q57Z06 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.4.4490 ^@ http://purl.uniprot.org/uniprot/Q583D4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.26.0560 ^@ http://purl.uniprot.org/uniprot/Q389K1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/185431:Tb927.4.1400 ^@ http://purl.uniprot.org/uniprot/Q581U1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb10.6k15.0430 ^@ http://purl.uniprot.org/uniprot/Q389Y9 ^@ Similarity ^@ Belongs to the CFAP298 family. http://togogenome.org/gene/185431:Tb09.160.0480 ^@ http://purl.uniprot.org/uniprot/Q38FZ2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/185431:Tb927.3.1070 ^@ http://purl.uniprot.org/uniprot/Q57WY8 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/185431:Tb927.7.3760 ^@ http://purl.uniprot.org/uniprot/Q57WJ1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.5.2430 ^@ http://purl.uniprot.org/uniprot/Q582C2 ^@ Similarity ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. http://togogenome.org/gene/185431:Tb927.6.5020 ^@ http://purl.uniprot.org/uniprot/Q586H4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/185431:Tb09.244.1410 ^@ http://purl.uniprot.org/uniprot/Q38CQ0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.3580 ^@ http://purl.uniprot.org/uniprot/Q580X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb09.211.2560 ^@ http://purl.uniprot.org/uniprot/Q38DQ0 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/185431:Tb927.5.5210 ^@ http://purl.uniprot.org/uniprot/Q57UD7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.406.0320 ^@ http://purl.uniprot.org/uniprot/Q389R8 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/185431:Tb10.389.1570 ^@ http://purl.uniprot.org/uniprot/Q389C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/185431:Tb10.6k15.3320 ^@ http://purl.uniprot.org/uniprot/Q38AM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.6540 ^@ http://purl.uniprot.org/uniprot/Q57Y75 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.61.0280 ^@ http://purl.uniprot.org/uniprot/Q387R5 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.6.4890 ^@ http://purl.uniprot.org/uniprot/Q586G1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/185431:Tb927.8.5980 ^@ http://purl.uniprot.org/uniprot/Q57YJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/185431:Tb927.7.460 ^@ http://purl.uniprot.org/uniprot/Q57U08 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/185431:Tb927.6.2920 ^@ http://purl.uniprot.org/uniprot/Q583P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.4.4070 ^@ http://purl.uniprot.org/uniprot/Q57Y11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.8.1920 ^@ http://purl.uniprot.org/uniprot/Q581Z0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus http://togogenome.org/gene/185431:Tb927.4.4890 ^@ http://purl.uniprot.org/uniprot/Q584L6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.70.1800 ^@ http://purl.uniprot.org/uniprot/Q38B76 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.5.1100 ^@ http://purl.uniprot.org/uniprot/Q57W55 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/185431:TB927.1.600 ^@ http://purl.uniprot.org/uniprot/Q4GZF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/185431:Tb10.406.0520 ^@ http://purl.uniprot.org/uniprot/Q389T8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Homodimer.|||Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase. http://togogenome.org/gene/185431:Tb927.5.4440 ^@ http://purl.uniprot.org/uniprot/Q57Z05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.4.1900 ^@ http://purl.uniprot.org/uniprot/Q583K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb09.211.3640 ^@ http://purl.uniprot.org/uniprot/Q38DE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.3.3950 ^@ http://purl.uniprot.org/uniprot/Q57WD1 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/185431:Tb927.8.1560 ^@ http://purl.uniprot.org/uniprot/Q580G7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb927.7.5650 ^@ http://purl.uniprot.org/uniprot/Q582I0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.5.1270 ^@ http://purl.uniprot.org/uniprot/Q57VD6 ^@ Similarity ^@ Belongs to the ANP32 family. http://togogenome.org/gene/185431:Tb09.211.2590 ^@ http://purl.uniprot.org/uniprot/Q38DP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb927.5.4320 ^@ http://purl.uniprot.org/uniprot/Q57Z17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.8.1530 ^@ http://purl.uniprot.org/uniprot/Q580H0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.2760 ^@ http://purl.uniprot.org/uniprot/Q57Y86 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/185431:Tb10.61.1910 ^@ http://purl.uniprot.org/uniprot/Q388C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/185431:Tb10.70.0930 ^@ http://purl.uniprot.org/uniprot/Q38B08 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb927.7.1020 ^@ http://purl.uniprot.org/uniprot/Q57VU8 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/185431:Tb927.8.7790 ^@ http://purl.uniprot.org/uniprot/Q57U64 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb09.211.2900 ^@ http://purl.uniprot.org/uniprot/Q38DL5 ^@ Similarity ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. http://togogenome.org/gene/185431:TB927.1.1630 ^@ http://purl.uniprot.org/uniprot/Q4GZ56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/185431:Tb927.7.4940 ^@ http://purl.uniprot.org/uniprot/Q57XB0 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/185431:Tb927.5.3940 ^@ http://purl.uniprot.org/uniprot/Q57U72 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/185431:Tb10.61.2530 ^@ http://purl.uniprot.org/uniprot/Q388H6 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/185431:Tb927.2.6320 ^@ http://purl.uniprot.org/uniprot/Q586M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.2440 ^@ http://purl.uniprot.org/uniprot/Q584R2 ^@ Similarity ^@ Belongs to the Mo25 family. http://togogenome.org/gene/185431:Tb927.4.1080 ^@ http://purl.uniprot.org/uniprot/Q580D6 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/185431:Tb10.70.6480 ^@ http://purl.uniprot.org/uniprot/Q38C92 ^@ Caution|||Developmental Stage|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although it belongs to the XPG/RAD2 endonuclease family, only one of the seven Asp residues involved in Mg(2+) binding is conserved suggesting that it has no nuclease activity.|||Belongs to the XPG/RAD2 endonuclease family.|||Cytoplasm|||Expressed in the procyclic and bloodstream forms (at protein level).|||Forms a complex composed of at least MKT1L, PBP1, XAC1 and LSM12.|||Involved in post-transcriptional regulation of gene expression.|||RNAi-mediated knockdown in both the procyclic and the bloodstream form is lethal. http://togogenome.org/gene/185431:Tb10.100.0080 ^@ http://purl.uniprot.org/uniprot/Q38CL9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/185431:Tb927.4.3880 ^@ http://purl.uniprot.org/uniprot/Q57XZ2 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb09.211.0350 ^@ http://purl.uniprot.org/uniprot/Q38EC4 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/185431:Tb927.8.6000 ^@ http://purl.uniprot.org/uniprot/Q57YK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane http://togogenome.org/gene/185431:Tb927.3.4750 ^@ http://purl.uniprot.org/uniprot/Q582Q6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/185431:Tb927.5.4240 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.6.4000 ^@ http://purl.uniprot.org/uniprot/Q585Z8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb10.70.5030 ^@ http://purl.uniprot.org/uniprot/Q38BY2 ^@ Similarity ^@ Belongs to the IST1 family. http://togogenome.org/gene/185431:Tb927.8.700 ^@ http://purl.uniprot.org/uniprot/Q57YG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability.|||Monomer.|||kinetoplast http://togogenome.org/gene/185431:Tb927.8.7170 ^@ http://purl.uniprot.org/uniprot/Q57YS3 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/185431:Tb09.244.0640 ^@ http://purl.uniprot.org/uniprot/Q38CP2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.950 ^@ http://purl.uniprot.org/uniprot/Q57VU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.3.1520 ^@ http://purl.uniprot.org/uniprot/Q57XY0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.1350 ^@ http://purl.uniprot.org/uniprot/Q581U6 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/185431:Tb10.26.1030 ^@ http://purl.uniprot.org/uniprot/Q389N7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.4.4460 ^@ http://purl.uniprot.org/uniprot/Q583D1 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.3.2500 ^@ http://purl.uniprot.org/uniprot/Q582W3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.5570 ^@ http://purl.uniprot.org/uniprot/Q580R8 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/185431:Tb927.4.3670 ^@ http://purl.uniprot.org/uniprot/Q585I3 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/185431:Tb927.8.3420 ^@ http://purl.uniprot.org/uniprot/Q57YX1 ^@ Similarity ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family. http://togogenome.org/gene/185431:Tb10.389.0300 ^@ http://purl.uniprot.org/uniprot/Q388T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/185431:Tb10.6k15.0270 ^@ http://purl.uniprot.org/uniprot/Q389X5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/185431:Tb10.100.0130 ^@ http://purl.uniprot.org/uniprot/Q38CL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.|||Peroxisome membrane http://togogenome.org/gene/185431:Tb927.8.7390 ^@ http://purl.uniprot.org/uniprot/Q57YU1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb10.70.5460 ^@ http://purl.uniprot.org/uniprot/Q38C17 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/185431:Tb10.61.0850 ^@ http://purl.uniprot.org/uniprot/Q387W1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/185431:Tb927.3.2410 ^@ http://purl.uniprot.org/uniprot/Q582V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/185431:Tb927.3.2840 ^@ http://purl.uniprot.org/uniprot/Q57ZM8 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/185431:Tb09.160.3670 ^@ http://purl.uniprot.org/uniprot/Q38F38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/185431:Tb927.6.980 ^@ http://purl.uniprot.org/uniprot/Q585F0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb10.70.6990 ^@ http://purl.uniprot.org/uniprot/Q38CC9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb09.211.4700 ^@ http://purl.uniprot.org/uniprot/Q38D40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.3640 ^@ http://purl.uniprot.org/uniprot/Q585W2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb10.70.4880 ^@ http://purl.uniprot.org/uniprot/Q38BW8 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/185431:Tb10.61.2290 ^@ http://purl.uniprot.org/uniprot/Q388F8 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/185431:Tb09.211.0440 ^@ http://purl.uniprot.org/uniprot/Q38EB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus http://togogenome.org/gene/185431:Tb927.8.4660 ^@ http://purl.uniprot.org/uniprot/Q57UY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Nucleus http://togogenome.org/gene/185431:Tb10.61.2100 ^@ http://purl.uniprot.org/uniprot/Q388E6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.8.720 ^@ http://purl.uniprot.org/uniprot/Q57YF8 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/185431:Tb927.3.3710 ^@ http://purl.uniprot.org/uniprot/Q57WA7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.7.2910 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.7.7360 ^@ http://purl.uniprot.org/uniprot/Q57TX3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb10.6k15.1750 ^@ http://purl.uniprot.org/uniprot/Q38A95 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. http://togogenome.org/gene/185431:Tb10.6k15.1240 ^@ http://purl.uniprot.org/uniprot/Q38A56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.8.2480 ^@ http://purl.uniprot.org/uniprot/Q57XE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/185431:Tb927.7.2250 ^@ http://purl.uniprot.org/uniprot/Q57XP9 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/185431:Tb927.6.4950 ^@ http://purl.uniprot.org/uniprot/Q586G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/185431:Tb927.7.2660 ^@ http://purl.uniprot.org/uniprot/Q57XK8 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Induction|||Subunit ^@ Expressed at low levels in the bloodstream form (at protein level) (PubMed:31743541, PubMed:32532821). Expressed in the procyclic form (PubMed:31743541).|||Induced during differentiation of bloodstream form to procyclic form.|||Interacts (via MKT1-binding motif) with MKT1.|||RNA-binding protein involved in regulation of mRNA stability (PubMed:31743541). Promotes mRNA stabilization by recruiting MKT1 and PBP1 (By similarity). Stabilizes mRNA required for differentiation from the bloodstream form to the procyclic form, and maintenance of the procyclic form (PubMed:31743541). Stabilizes transcripts encoding membrane and mitochondrial proteins, including AQP1 and GPEET2 procyclin (PubMed:31743541).|||RNAi-mediated knockdown causes abnormal differentiation of the bloodstream form into the procyclic form, a reduction in the expression of several mRNA including differentiation protein PAD1, and premature death (PubMed:31743541). RNAi-mediated knockdown at the procyclic stage causes a decrease in growth rate (PubMed:31743541). Simultaneous RNAi-mediated knockdown of ZC3H20 and ZC3H21 at the bloodstream stage is lethal (PubMed:31743541). Simultaneous RNAi-mediated knockdown of ZC3H20 and ZC3H21 at the procyclic stage causes a severe growth defect and a shift towards a bloodstream form (PubMed:31743541). http://togogenome.org/gene/185431:Tb927.7.5000 ^@ http://purl.uniprot.org/uniprot/Q57ZI7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL19 family. http://togogenome.org/gene/185431:Tb09.211.2580 ^@ http://purl.uniprot.org/uniprot/Q38DP8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/185431:Tb927.6.1080 ^@ http://purl.uniprot.org/uniprot/Q585D9 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/185431:Tb927.4.1870 ^@ http://purl.uniprot.org/uniprot/Q583K6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb927.2.6410 ^@ http://purl.uniprot.org/uniprot/Q586M4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.7410 ^@ http://purl.uniprot.org/uniprot/Q57YU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/185431:TB927.1.1400 ^@ http://purl.uniprot.org/uniprot/Q4GZ79 ^@ Similarity ^@ Belongs to the OPI10 family. http://togogenome.org/gene/185431:Tb927.7.5480 ^@ http://purl.uniprot.org/uniprot/Q582G3 ^@ Function|||Similarity ^@ Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.|||In the C-terminal section; belongs to the thymidylate synthase family.|||In the N-terminal section; belongs to the dihydrofolate reductase family. http://togogenome.org/gene/185431:Tb10.61.0380 ^@ http://purl.uniprot.org/uniprot/Q387S3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.5.3510 ^@ http://purl.uniprot.org/uniprot/Q57UB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.5800 ^@ http://purl.uniprot.org/uniprot/Q38C41 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/185431:Tb927.8.4810 ^@ http://purl.uniprot.org/uniprot/Q57UX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.6.2740 ^@ http://purl.uniprot.org/uniprot/D6XI07 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/185431:Tb927.4.3870 ^@ http://purl.uniprot.org/uniprot/Q583I1 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.6.3510 ^@ http://purl.uniprot.org/uniprot/Q584Z1 ^@ Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/185431:Tb09.160.4570 ^@ http://purl.uniprot.org/uniprot/Q38EV1 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/185431:Tb927.7.1340 ^@ http://purl.uniprot.org/uniprot/Q57WR6 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/185431:Tb927.5.4550 ^@ http://purl.uniprot.org/uniprot/Q57X49 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.4.5010 ^@ http://purl.uniprot.org/uniprot/Q584K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/185431:Tb927.8.3860 ^@ http://purl.uniprot.org/uniprot/Q581A6 ^@ Function|||Similarity ^@ Belongs to the WD repeat CIA1 family.|||Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. http://togogenome.org/gene/185431:Tb09.160.0580 ^@ http://purl.uniprot.org/uniprot/Q38FY1 ^@ Similarity ^@ Belongs to the peptidase M67A family. BRCC36 subfamily. http://togogenome.org/gene/185431:Tb927.8.7020 ^@ http://purl.uniprot.org/uniprot/Q57YQ9 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/185431:Tb927.6.1960 ^@ http://purl.uniprot.org/uniprot/Q585L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Belongs to the glycosyltransferase 28 family.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/185431:Tb10.70.5600 ^@ http://purl.uniprot.org/uniprot/Q38C29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.8.1710 ^@ http://purl.uniprot.org/uniprot/Q580F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.8.2600 ^@ http://purl.uniprot.org/uniprot/Q57XC9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/185431:Tb927.5.1000 ^@ http://purl.uniprot.org/uniprot/Q57W45 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/185431:Tb10.6k15.0030 ^@ http://purl.uniprot.org/uniprot/Q389V2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Major surface antigen of procyclic forms.|||Membrane http://togogenome.org/gene/185431:Tb10.70.0090 ^@ http://purl.uniprot.org/uniprot/Q38AT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.7.2200 ^@ http://purl.uniprot.org/uniprot/Q57XQ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/185431:Tb927.3.1400 ^@ http://purl.uniprot.org/uniprot/Q57XX3 ^@ Function|||Similarity ^@ Belongs to the acetyltransferase ATAT1 family.|||Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. http://togogenome.org/gene/185431:Tb10.05.0200 ^@ http://purl.uniprot.org/uniprot/Q388Q0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.4.5530 ^@ http://purl.uniprot.org/uniprot/Q580P1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.4140 ^@ http://purl.uniprot.org/uniprot/Q57UP4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL21 family. http://togogenome.org/gene/185431:Tb927.3.2480 ^@ http://purl.uniprot.org/uniprot/Q582W1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane|||Regulates also the sphingolipid metabolism. http://togogenome.org/gene/185431:Tb10.61.3010 ^@ http://purl.uniprot.org/uniprot/Q388K9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.70.3930 ^@ http://purl.uniprot.org/uniprot/Q38BP7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb10.70.5540 ^@ http://purl.uniprot.org/uniprot/Q38C23 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/185431:Tb927.7.970 ^@ http://purl.uniprot.org/uniprot/Q57VU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb09.160.3510 ^@ http://purl.uniprot.org/uniprot/Q38F54 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/185431:Tb927.5.3070 ^@ http://purl.uniprot.org/uniprot/Q57Z86 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb927.7.3340 ^@ http://purl.uniprot.org/uniprot/Q57WE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.8.1180 ^@ http://purl.uniprot.org/uniprot/Q57VN6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/185431:Tb927.4.3290 ^@ http://purl.uniprot.org/uniprot/Q584A6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.1510 ^@ http://purl.uniprot.org/uniprot/Q581T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/185431:Tb927.3.4540 ^@ http://purl.uniprot.org/uniprot/Q580I8 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb09.211.3540 ^@ http://purl.uniprot.org/uniprot/Q38DF3 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/185431:Tb927.5.3820 ^@ http://purl.uniprot.org/uniprot/Q57U84 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/185431:Tb927.7.2590 ^@ http://purl.uniprot.org/uniprot/Q57XL5 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/185431:Tb10.61.3180 ^@ http://purl.uniprot.org/uniprot/Q388M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/185431:Tb927.5.1300 ^@ http://purl.uniprot.org/uniprot/Q57VD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/185431:Tb927.6.1540 ^@ http://purl.uniprot.org/uniprot/Q585Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb09.160.3480 ^@ http://purl.uniprot.org/uniprot/Q38F57 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.4.5020 ^@ http://purl.uniprot.org/uniprot/Q584K3 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/185431:Tb10.61.2550 ^@ http://purl.uniprot.org/uniprot/Q388H8 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/185431:Tb927.7.7430 ^@ http://purl.uniprot.org/uniprot/Q57TX9 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/185431:Tb927.6.5040 ^@ http://purl.uniprot.org/uniprot/Q586H6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/185431:Tb927.2.6130 ^@ http://purl.uniprot.org/uniprot/Q586N6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.4770 ^@ http://purl.uniprot.org/uniprot/Q57X93 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb10.70.5630 ^@ http://purl.uniprot.org/uniprot/Q38C30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).|||Belongs to the VPS51 family.|||Component of the Golgi-associated retrograde protein (GARP) complex.|||trans-Golgi network http://togogenome.org/gene/185431:Tb927.6.1420 ^@ http://purl.uniprot.org/uniprot/Q585A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.1330 ^@ http://purl.uniprot.org/uniprot/Q38E22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.6k15.3230 ^@ http://purl.uniprot.org/uniprot/Q38AM0 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/185431:Tb10.70.6330 ^@ http://purl.uniprot.org/uniprot/Q38C83 ^@ Function|||Similarity ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. http://togogenome.org/gene/185431:Tb927.2.2260 ^@ http://purl.uniprot.org/uniprot/Q586K5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.3.1140 ^@ http://purl.uniprot.org/uniprot/Q57WZ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.4.3630 ^@ http://purl.uniprot.org/uniprot/Q585I7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb927.7.2440 ^@ http://purl.uniprot.org/uniprot/Q57XN0 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/185431:Tb09.160.0450 ^@ http://purl.uniprot.org/uniprot/Q38FZ6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.5.4250 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.70.5290 ^@ http://purl.uniprot.org/uniprot/Q38C03 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/185431:Tb10.70.0540 ^@ http://purl.uniprot.org/uniprot/Q38AX7 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. http://togogenome.org/gene/185431:Tb09.211.3510 ^@ http://purl.uniprot.org/uniprot/Q38DF6 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. http://togogenome.org/gene/185431:Tb927.2.4410 ^@ http://purl.uniprot.org/uniprot/Q586P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.5380 ^@ http://purl.uniprot.org/uniprot/Q38C09 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/185431:Tb927.3.2960 ^@ http://purl.uniprot.org/uniprot/Q57ZL6 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/185431:Tb09.v1.0380 ^@ http://purl.uniprot.org/uniprot/Q38EH6 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/185431:Tb09.211.3850 ^@ http://purl.uniprot.org/uniprot/Q38DC4 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/185431:Tb09.211.4360 ^@ http://purl.uniprot.org/uniprot/Q38D75 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb927.8.6840 ^@ http://purl.uniprot.org/uniprot/Q57TS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.2180 ^@ http://purl.uniprot.org/uniprot/Q38B99 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/185431:Tb10.61.1360 ^@ http://purl.uniprot.org/uniprot/Q387Z6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/185431:Tb927.6.990 ^@ http://purl.uniprot.org/uniprot/Q585E8 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb10.61.1850 ^@ http://purl.uniprot.org/uniprot/Q387N8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb10.406.0540 ^@ http://purl.uniprot.org/uniprot/Q389T9 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. http://togogenome.org/gene/185431:Tb10.70.5200 ^@ http://purl.uniprot.org/uniprot/Q38BZ6 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/185431:Tb927.7.4650 ^@ http://purl.uniprot.org/uniprot/D6XIZ6|||http://purl.uniprot.org/uniprot/Q57X81 ^@ Cofactor|||Developmental Stage|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Binds 1 Fe(2+) ion per subunit.|||Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, however it binds chromatin.|||Expressed in bloodstream form.|||In the C-terminal section; belongs to the SNF2/RAD54 helicase family.|||In the N-terminal section; belongs to the TET family. JBP2 subfamily.|||Nucleus|||The genome contains reduced level of DNA base J in the DNA. Cells lacking both JBP1 and JBP2 show a complete absence of base J. http://togogenome.org/gene/185431:Tb927.6.5450 ^@ http://purl.uniprot.org/uniprot/Q583L5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.3500 ^@ http://purl.uniprot.org/uniprot/Q57YW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MET18/MMS19 family.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus http://togogenome.org/gene/185431:Tb927.4.3940 ^@ http://purl.uniprot.org/uniprot/Q57XZ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.7.2780 ^@ http://purl.uniprot.org/uniprot/Q57Y88 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Expressed in the bloodstream form (at protein level).|||Forms a complex composed of at least MKT1, PBP1, XAC1 and LSM12 (PubMed:32532821). Forms a complex composed of at least MKT1L, PBP1, XAC1 and LSM12 (PubMed:32532821).|||Involved in post-transcriptional regulation of gene expression.|||RNAi-mediated knockdown in the bloodstream form abolishes cell population growth. http://togogenome.org/gene/185431:Tb10.61.0990 ^@ http://purl.uniprot.org/uniprot/Q387X3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb09.160.1440 ^@ http://purl.uniprot.org/uniprot/Q38FP4 ^@ Similarity ^@ Belongs to the MAPRE family. http://togogenome.org/gene/185431:Tb927.7.2370 ^@ http://purl.uniprot.org/uniprot/Q57XN7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/185431:Tb927.8.1650 ^@ http://purl.uniprot.org/uniprot/Q580F8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:TB927.1.3130 ^@ http://purl.uniprot.org/uniprot/Q4GYR0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.3.3280 ^@ http://purl.uniprot.org/uniprot/Q57V58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Membrane http://togogenome.org/gene/185431:Tb927.5.4840 ^@ http://purl.uniprot.org/uniprot/Q57X36 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.160.4680 ^@ http://purl.uniprot.org/uniprot/Q38ET8 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/185431:Tb927.7.2870 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.8.7320 ^@ http://purl.uniprot.org/uniprot/Q57YT4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.6k15.2350 ^@ http://purl.uniprot.org/uniprot/Q38AE7 ^@ Similarity ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family. http://togogenome.org/gene/185431:Tb927.3.1270 ^@ http://purl.uniprot.org/uniprot/Q57XW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/185431:Tb927.6.1020 ^@ http://purl.uniprot.org/uniprot/Q585E5 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb10.406.0460 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.5.2690 ^@ http://purl.uniprot.org/uniprot/Q57ZU5 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/185431:Tb09.211.3310 ^@ http://purl.uniprot.org/uniprot/Q38DH5 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/185431:Tb10.61.0630 ^@ http://purl.uniprot.org/uniprot/Q387U5 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/185431:Tb10.61.2910 ^@ http://purl.uniprot.org/uniprot/Q388K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/185431:Tb927.7.5940 ^@ http://purl.uniprot.org/uniprot/Q582K9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.05.0220 ^@ http://purl.uniprot.org/uniprot/Q383V8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/185431:Tb10.61.1390 ^@ http://purl.uniprot.org/uniprot/Q586C2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/185431:Tb10.70.2520 ^@ http://purl.uniprot.org/uniprot/Q38BD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/185431:Tb10.6k15.1100 ^@ http://purl.uniprot.org/uniprot/Q38A44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.389.0670 ^@ http://purl.uniprot.org/uniprot/Q388W0 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/185431:TB927.1.2820 ^@ http://purl.uniprot.org/uniprot/Q4GYU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.2650 ^@ http://purl.uniprot.org/uniprot/Q38DN9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/185431:Tb927.5.1700 ^@ http://purl.uniprot.org/uniprot/Q57ZN9 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/185431:Tb927.7.2820 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.70.3240 ^@ http://purl.uniprot.org/uniprot/Q38BJ6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/185431:Tb927.5.320 ^@ http://purl.uniprot.org/uniprot/Q57VY1 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.6.5370 ^@ http://purl.uniprot.org/uniprot/Q583L6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.5.1730 ^@ http://purl.uniprot.org/uniprot/D6XGB1|||http://purl.uniprot.org/uniprot/Q57ZP2 ^@ Similarity ^@ Belongs to the protease inhibitor I11 (ecotin) family. http://togogenome.org/gene/185431:Tb09.160.3690 ^@ http://purl.uniprot.org/uniprot/Q38F36 ^@ Similarity ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily. http://togogenome.org/gene/185431:Tb927.5.450 ^@ http://purl.uniprot.org/uniprot/Q57VW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb09.244.2760 ^@ http://purl.uniprot.org/uniprot/Q38CZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/185431:Tb927.3.1100 ^@ http://purl.uniprot.org/uniprot/Q57WZ1 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/185431:Tb927.7.4400 ^@ http://purl.uniprot.org/uniprot/Q57X56 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/185431:Tb927.8.980 ^@ http://purl.uniprot.org/uniprot/Q57XH7 ^@ Cofactor|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/185431:Tb10.70.0280 ^@ http://purl.uniprot.org/uniprot/Q38AV5 ^@ Function|||Similarity ^@ Belongs to the chaperonin (HSP60) family.|||Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. http://togogenome.org/gene/185431:Tb10.70.7330 ^@ http://purl.uniprot.org/uniprot/Q38CF7 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/185431:Tb10.6k15.1520 ^@ http://purl.uniprot.org/uniprot/Q38A82 ^@ Similarity ^@ Belongs to the GTR/RAG GTP-binding protein family. http://togogenome.org/gene/185431:Tb927.6.1350 ^@ http://purl.uniprot.org/uniprot/Q585B2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.5680 ^@ http://purl.uniprot.org/uniprot/Q57X14 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/185431:Tb927.6.780 ^@ http://purl.uniprot.org/uniprot/Q583S5 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.406.0130 ^@ http://purl.uniprot.org/uniprot/Q389Q3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/185431:Tb927.7.190 ^@ http://purl.uniprot.org/uniprot/Q57U35 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/185431:TB927.1.1600 ^@ http://purl.uniprot.org/uniprot/Q4GZ59 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/185431:Tb09.244.2800 ^@ http://purl.uniprot.org/uniprot/Q38CZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||cytoskeleton http://togogenome.org/gene/185431:Tb10.389.1430 ^@ http://purl.uniprot.org/uniprot/Q389B2 ^@ Similarity ^@ Belongs to the asfivirus helicase A859L family. http://togogenome.org/gene/185431:Tb927.6.3210 ^@ http://purl.uniprot.org/uniprot/Q584W4 ^@ Caution|||Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb09.160.4450 ^@ http://purl.uniprot.org/uniprot/Q38EW1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS3 family. http://togogenome.org/gene/185431:Tb927.2.6210 ^@ http://purl.uniprot.org/uniprot/Q586N2 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb09.160.3990 ^@ http://purl.uniprot.org/uniprot/Q38F06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/185431:Tb927.3.2040 ^@ http://purl.uniprot.org/uniprot/Q57ZA7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.4.4540 ^@ http://purl.uniprot.org/uniprot/Q583D9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb10.70.3170 ^@ http://purl.uniprot.org/uniprot/Q38BI9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/185431:Tb10.70.3710 ^@ http://purl.uniprot.org/uniprot/Q38BN3 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/185431:Tb10.406.0390 ^@ http://purl.uniprot.org/uniprot/Q389S5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.3.4910 ^@ http://purl.uniprot.org/uniprot/Q582P4 ^@ Similarity ^@ Belongs to the peptidase A22B family. http://togogenome.org/gene/185431:Tb927.8.640 ^@ http://purl.uniprot.org/uniprot/Q57YG6 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/185431:Tb927.8.4890 ^@ http://purl.uniprot.org/uniprot/Q57UW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/185431:Tb927.3.4810 ^@ http://purl.uniprot.org/uniprot/Q582Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.3.4230 ^@ http://purl.uniprot.org/uniprot/Q580L9 ^@ Caution|||Similarity ^@ Belongs to the peptidase S8 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb09.160.0780 ^@ http://purl.uniprot.org/uniprot/Q38FW1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/185431:Tb927.6.2880 ^@ http://purl.uniprot.org/uniprot/Q583P6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb10.05.0230 ^@ http://purl.uniprot.org/uniprot/Q388P7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb927.6.2270 ^@ http://purl.uniprot.org/uniprot/Q584S3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/185431:Tb927.4.1090 ^@ http://purl.uniprot.org/uniprot/Q580D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.0830 ^@ http://purl.uniprot.org/uniprot/Q38B01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/185431:Tb927.2.4620 ^@ http://purl.uniprot.org/uniprot/Q586R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.1190 ^@ http://purl.uniprot.org/uniprot/Q38E36 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/185431:Tb927.7.2900 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.3.2150 ^@ http://purl.uniprot.org/uniprot/Q57Z96 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/185431:Tb927.6.1860 ^@ http://purl.uniprot.org/uniprot/Q585M5 ^@ Similarity ^@ Belongs to the RRF family. http://togogenome.org/gene/185431:Tb927.7.3960 ^@ http://purl.uniprot.org/uniprot/Q57UM6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/185431:Tb09.160.5440 ^@ http://purl.uniprot.org/uniprot/Q38EK4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.406.0450 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.6k15.2130 ^@ http://purl.uniprot.org/uniprot/Q38AC8 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/185431:Tb927.8.7940 ^@ http://purl.uniprot.org/uniprot/Q57U51 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.2.5980 ^@ http://purl.uniprot.org/uniprot/Q586B8 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/185431:Tb927.2.5800 ^@ http://purl.uniprot.org/uniprot/Q586C9 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/185431:Tb09.211.3610 ^@ http://purl.uniprot.org/uniprot/Q38DE8 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/185431:Tb10.70.1900 ^@ http://purl.uniprot.org/uniprot/Q38B82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.2680 ^@ http://purl.uniprot.org/uniprot/Q38BE7 ^@ Similarity ^@ Belongs to the ARPC3 family. http://togogenome.org/gene/185431:Tb927.6.4810 ^@ http://purl.uniprot.org/uniprot/Q586F3 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/185431:Tb927.8.1510 ^@ http://purl.uniprot.org/uniprot/Q580H2 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. http://togogenome.org/gene/185431:Tb927.7.240 ^@ http://purl.uniprot.org/uniprot/Q57U30 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/185431:TB927.1.2040 ^@ http://purl.uniprot.org/uniprot/Q4GZ15 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.1710 ^@ http://purl.uniprot.org/uniprot/Q57V39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.7.6110 ^@ http://purl.uniprot.org/uniprot/Q57VK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/185431:Tb927.7.2060 ^@ http://purl.uniprot.org/uniprot/Q57V05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/185431:Tb09.160.4250 ^@ http://purl.uniprot.org/uniprot/Q38EX8 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/185431:Tb10.6k15.1410 ^@ http://purl.uniprot.org/uniprot/Q38A72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/185431:Tb927.7.2850 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.5.500 ^@ http://purl.uniprot.org/uniprot/Q57VW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC7 family.|||cilium axoneme|||flagellum http://togogenome.org/gene/185431:Tb927.8.3510 ^@ http://purl.uniprot.org/uniprot/Q57YW2 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/185431:Tb927.2.6230 ^@ http://purl.uniprot.org/uniprot/Q586N0 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb927.3.4690 ^@ http://purl.uniprot.org/uniprot/Q582R6 ^@ Similarity ^@ Belongs to the TDD superfamily. DTWD2 family. http://togogenome.org/gene/185431:Tb927.3.4190 ^@ http://purl.uniprot.org/uniprot/Q580M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/185431:Tb927.5.3020 ^@ http://purl.uniprot.org/uniprot/Q57ZX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/185431:Tb927.8.1980 ^@ http://purl.uniprot.org/uniprot/Q581Y4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/185431:Tb927.5.2780 ^@ http://purl.uniprot.org/uniprot/D6XGL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/185431:Tb927.7.3770 ^@ http://purl.uniprot.org/uniprot/Q57WJ2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family. http://togogenome.org/gene/185431:Tb09.211.1960 ^@ http://purl.uniprot.org/uniprot/Q38DV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/185431:Tb10.70.0520 ^@ http://purl.uniprot.org/uniprot/Q38AX5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Nucleus|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport.|||The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). http://togogenome.org/gene/185431:Tb10.70.7010 ^@ http://purl.uniprot.org/uniprot/Q38CD0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/185431:Tb927.3.1760 ^@ http://purl.uniprot.org/uniprot/Q57ZD5 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/185431:Tb10.61.2970 ^@ http://purl.uniprot.org/uniprot/Q388K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/185431:Tb927.4.1660 ^@ http://purl.uniprot.org/uniprot/Q581R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.7.7520 ^@ http://purl.uniprot.org/uniprot/Q57TY9 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.8.2240 ^@ http://purl.uniprot.org/uniprot/Q581V8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb09.244.0050 ^@ http://purl.uniprot.org/uniprot/Q38CM7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.2450 ^@ http://purl.uniprot.org/uniprot/Q57XE4 ^@ Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family. http://togogenome.org/gene/185431:TB927.1.05 ^@ http://purl.uniprot.org/uniprot/Q4GZE7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.61.2200 ^@ http://purl.uniprot.org/uniprot/Q388F1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.|||Endoplasmic reticulum membrane|||Probable GTP-binding protein that may be involved in cell development. http://togogenome.org/gene/185431:Tb09.244.2730 ^@ http://purl.uniprot.org/uniprot/Q38CY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/185431:Tb10.70.1230 ^@ http://purl.uniprot.org/uniprot/Q38B29 ^@ Similarity ^@ Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family. http://togogenome.org/gene/185431:Tb09.211.0590 ^@ http://purl.uniprot.org/uniprot/Q38E99 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/185431:Tb10.26.0670 ^@ http://purl.uniprot.org/uniprot/Q389K8 ^@ Similarity ^@ Belongs to the IFT57 family. http://togogenome.org/gene/185431:Tb10.70.7690 ^@ http://purl.uniprot.org/uniprot/Q38CI3 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/185431:Tb09.211.1250 ^@ http://purl.uniprot.org/uniprot/Q38E30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. http://togogenome.org/gene/185431:Tb10.61.0250 ^@ http://purl.uniprot.org/uniprot/Q387R2 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/185431:Tb927.7.2540 ^@ http://purl.uniprot.org/uniprot/Q57XM0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/185431:Tb927.6.4300 ^@ http://purl.uniprot.org/uniprot/Q586Z6 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/185431:Tb927.8.7300 ^@ http://purl.uniprot.org/uniprot/Q57YT2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.211.2920 ^@ http://purl.uniprot.org/uniprot/Q38DL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.5550 ^@ http://purl.uniprot.org/uniprot/Q583L4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.61.2745 ^@ http://purl.uniprot.org/uniprot/Q388J2 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/185431:Tb10.26.0590 ^@ http://purl.uniprot.org/uniprot/Q389K4 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/185431:Tb927.8.8330 ^@ http://purl.uniprot.org/uniprot/Q57WJ7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb10.61.0500 ^@ http://purl.uniprot.org/uniprot/Q387T4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/185431:Tb927.8.2770 ^@ http://purl.uniprot.org/uniprot/Q57XB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.6k15.3020 ^@ http://purl.uniprot.org/uniprot/Q38AK1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb10.70.7030 ^@ http://purl.uniprot.org/uniprot/Q38CD1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/185431:Tb927.4.4340 ^@ http://purl.uniprot.org/uniprot/Q57Y38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cytoplasm http://togogenome.org/gene/185431:Tb10.389.1360 ^@ http://purl.uniprot.org/uniprot/Q389A6 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/185431:Tb09.160.4300 ^@ http://purl.uniprot.org/uniprot/Q38EX7 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/185431:Tb927.3.3730 ^@ http://purl.uniprot.org/uniprot/Q57WA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.3.3360 ^@ http://purl.uniprot.org/uniprot/Q57V50 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/185431:Tb09.211.2850 ^@ http://purl.uniprot.org/uniprot/Q38DM0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb09.211.2870 ^@ http://purl.uniprot.org/uniprot/Q38DL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.|||Nucleus http://togogenome.org/gene/185431:Tb927.6.500 ^@ http://purl.uniprot.org/uniprot/Q581F5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.211.2370 ^@ http://purl.uniprot.org/uniprot/Q38DS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.1130 ^@ http://purl.uniprot.org/uniprot/Q57VP1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb10.61.3210 ^@ http://purl.uniprot.org/uniprot/Q388M8 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/185431:Tb927.5.900 ^@ http://purl.uniprot.org/uniprot/Q57W35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.7150 ^@ http://purl.uniprot.org/uniprot/Q57YS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:TB927.1.3030 ^@ http://purl.uniprot.org/uniprot/P86925 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA ligase 2 family.|||Component of the RNA editing complex, a 1600 kDa complex composed of at least 20 proteins.|||Mitochondrion|||RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs. http://togogenome.org/gene/185431:Tb10.406.0370 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.61.3140 ^@ http://purl.uniprot.org/uniprot/Q388M1 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.|||Inhibited by cyclin kinase 2 (CDK2) inhibitors, including GW8510.|||Was identified as a drug target for the treatment of African sleeping sickness. RNA interference leads to growth arrest and altered parasite morphology, demonstrating requirement for cell survival. http://togogenome.org/gene/185431:Tb927.5.2660 ^@ http://purl.uniprot.org/uniprot/Q57ZU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/185431:Tb927.5.3220 ^@ http://purl.uniprot.org/uniprot/Q57Z71 ^@ Similarity ^@ Belongs to the peptidase S26B family. http://togogenome.org/gene/185431:Tb927.8.3430 ^@ http://purl.uniprot.org/uniprot/Q57YX0 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/185431:Tb927.6.3890 ^@ http://purl.uniprot.org/uniprot/Q585Y7 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/185431:Tb927.4.5390 ^@ http://purl.uniprot.org/uniprot/Q580P8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb09.211.1370 ^@ http://purl.uniprot.org/uniprot/Q38E18 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/185431:Tb10.70.0260 ^@ http://purl.uniprot.org/uniprot/Q38AV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.8.5970 ^@ http://purl.uniprot.org/uniprot/Q57YJ8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/185431:Tb927.4.2520 ^@ http://purl.uniprot.org/uniprot/Q584D5 ^@ Cofactor|||Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-57 and Arg-60) that bind to malonylated and succinylated substrates and define the specificity.|||Mitochondrion|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/185431:Tb927.8.1310 ^@ http://purl.uniprot.org/uniprot/Q57VM4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/185431:Tb927.8.3180 ^@ http://purl.uniprot.org/uniprot/Q57YZ5 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/185431:Tb09.244.2700 ^@ http://purl.uniprot.org/uniprot/Q38CY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.4.3590 ^@ http://purl.uniprot.org/uniprot/Q585J1 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/185431:Tb09.211.3180 ^@ http://purl.uniprot.org/uniprot/Q38DI7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/185431:Tb927.8.5990 ^@ http://purl.uniprot.org/uniprot/Q57YK0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/185431:Tb09.244.1830 ^@ http://purl.uniprot.org/uniprot/Q38CQ9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.0170 ^@ http://purl.uniprot.org/uniprot/Q38AU5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.3.3400 ^@ http://purl.uniprot.org/uniprot/Q57V46 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb10.61.0810 ^@ http://purl.uniprot.org/uniprot/Q387V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/185431:Tb927.3.1530 ^@ http://purl.uniprot.org/uniprot/Q57XY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/185431:Tb09.160.0815 ^@ http://purl.uniprot.org/uniprot/Q38FV6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/185431:Tb10.389.1220 ^@ http://purl.uniprot.org/uniprot/Q388Z5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.180 ^@ http://purl.uniprot.org/uniprot/Q57U36 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.6k15.1960 ^@ http://purl.uniprot.org/uniprot/Q38AB4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/185431:Tb10.6k15.0560 ^@ http://purl.uniprot.org/uniprot/Q38A01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||nucleoplasm http://togogenome.org/gene/185431:Tb10.389.1290 ^@ http://purl.uniprot.org/uniprot/Q389A0 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/185431:Tb927.2.2970 ^@ http://purl.uniprot.org/uniprot/Q587G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.4920 ^@ http://purl.uniprot.org/uniprot/Q38D18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.3.1150 ^@ http://purl.uniprot.org/uniprot/Q57WZ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/185431:Tb927.2.6180 ^@ http://purl.uniprot.org/uniprot/Q586N4 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb927.4.1270 ^@ http://purl.uniprot.org/uniprot/Q581V4 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/185431:Tb927.3.2650 ^@ http://purl.uniprot.org/uniprot/Q582X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/185431:Tb10.70.2210 ^@ http://purl.uniprot.org/uniprot/Q38BA2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.7.2800 ^@ http://purl.uniprot.org/uniprot/Q57Y90 ^@ Similarity ^@ Belongs to the PRP18 family. http://togogenome.org/gene/185431:Tb927.3.4680 ^@ http://purl.uniprot.org/uniprot/Q582R7 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/185431:Tb927.3.5580 ^@ http://purl.uniprot.org/uniprot/Q580R7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb10.6k15.1820 ^@ http://purl.uniprot.org/uniprot/Q38AA1 ^@ Similarity ^@ Belongs to the CNOT10 family. http://togogenome.org/gene/185431:Tb10.70.0080 ^@ http://purl.uniprot.org/uniprot/Q38AT8 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:TB927.1.3050 ^@ http://purl.uniprot.org/uniprot/Q4GYR8 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.6.4280 ^@ http://purl.uniprot.org/uniprot/Q586Z5 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/185431:Tb10.6k15.3650 ^@ http://purl.uniprot.org/uniprot/Q38AQ5 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/185431:Tb927.7.5680 ^@ http://purl.uniprot.org/uniprot/Q582I3 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. http://togogenome.org/gene/185431:Tb09.160.4280 ^@ http://purl.uniprot.org/uniprot/Q38EX8 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/185431:Tb10.389.1790 ^@ http://purl.uniprot.org/uniprot/Q389E3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/185431:Tb927.3.2230 ^@ http://purl.uniprot.org/uniprot/Q582T6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/185431:Tb927.7.6350 ^@ http://purl.uniprot.org/uniprot/Q582M4 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/185431:Tb927.4.480 ^@ http://purl.uniprot.org/uniprot/Q57US7 ^@ Function ^@ Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. http://togogenome.org/gene/185431:Tb927.7.5910 ^@ http://purl.uniprot.org/uniprot/Q582K6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/185431:Tb09.244.2725 ^@ http://purl.uniprot.org/uniprot/Q38CY6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/185431:Tb927.8.8030 ^@ http://purl.uniprot.org/uniprot/Q57U42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.480 ^@ http://purl.uniprot.org/uniprot/Q57XI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.1370 ^@ http://purl.uniprot.org/uniprot/Q585B0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.6170 ^@ http://purl.uniprot.org/uniprot/Q57VJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/185431:Tb927.4.5400 ^@ http://purl.uniprot.org/uniprot/Q580P7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.2540 ^@ http://purl.uniprot.org/uniprot/Q57XD5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/185431:Tb927.6.2840 ^@ http://purl.uniprot.org/uniprot/Q583Q0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/185431:Tb09.211.3570 ^@ http://purl.uniprot.org/uniprot/Q38DF0 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/185431:Tb927.6.4880 ^@ http://purl.uniprot.org/uniprot/Q586G3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/185431:Tb927.8.1640 ^@ http://purl.uniprot.org/uniprot/Q580F9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/185431:Tb927.8.1150 ^@ http://purl.uniprot.org/uniprot/Q57VN9 ^@ Similarity ^@ Belongs to the GORAB family. http://togogenome.org/gene/185431:Tb927.6.300 ^@ http://purl.uniprot.org/uniprot/Q581E2 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.6.720 ^@ http://purl.uniprot.org/uniprot/Q583T1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/185431:Tb927.4.5300 ^@ http://purl.uniprot.org/uniprot/Q580Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.6.4760 ^@ http://purl.uniprot.org/uniprot/Q587E2 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/185431:Tb927.4.3640 ^@ http://purl.uniprot.org/uniprot/Q585I6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb10.6k15.1400 ^@ http://purl.uniprot.org/uniprot/Q38A71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/185431:Tb10.61.0490 ^@ http://purl.uniprot.org/uniprot/Q387T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/185431:Tb09.160.3960 ^@ http://purl.uniprot.org/uniprot/Q38F11 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/185431:Tb09.160.2450 ^@ http://purl.uniprot.org/uniprot/Q38FE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb10.61.1090 ^@ http://purl.uniprot.org/uniprot/Q387X7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/185431:Tb09.160.2490 ^@ http://purl.uniprot.org/uniprot/Q38FE4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/185431:Tb927.7.4340 ^@ http://purl.uniprot.org/uniprot/Q57UR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/185431:Tb927.3.150 ^@ http://purl.uniprot.org/uniprot/Q57TS0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.3270 ^@ http://purl.uniprot.org/uniprot/D6XDN4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by AMP.|||Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Glycosome|||Homotetramer. http://togogenome.org/gene/185431:Tb10.6k15.0340 ^@ http://purl.uniprot.org/uniprot/Q389Y2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.2920 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.6.1040 ^@ http://purl.uniprot.org/uniprot/Q585E3 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb927.2.1720 ^@ http://purl.uniprot.org/uniprot/Q585S1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/185431:Tb10.61.2090 ^@ http://purl.uniprot.org/uniprot/Q385T6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/185431:Tb10.26.0210 ^@ http://purl.uniprot.org/uniprot/Q389H2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb10.70.1490 ^@ http://purl.uniprot.org/uniprot/Q38B52 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/185431:Tb927.6.1630 ^@ http://purl.uniprot.org/uniprot/Q585P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.6500 ^@ http://purl.uniprot.org/uniprot/Q57TW3 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/185431:Tb10.61.0330 ^@ http://purl.uniprot.org/uniprot/Q387R9 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/185431:Tb927.7.2050 ^@ http://purl.uniprot.org/uniprot/Q57V06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.2.2990 ^@ http://purl.uniprot.org/uniprot/Q587G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.3600 ^@ http://purl.uniprot.org/uniprot/Q38BM3 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/185431:Tb09.211.4155 ^@ http://purl.uniprot.org/uniprot/Q38D93 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/185431:Tb927.6.790 ^@ http://purl.uniprot.org/uniprot/Q583S4 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.70.6450 ^@ http://purl.uniprot.org/uniprot/Q38C90 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.5.2760 ^@ http://purl.uniprot.org/uniprot/Q57ZV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.3.3630 ^@ http://purl.uniprot.org/uniprot/Q57W99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/185431:Tb09.160.4700 ^@ http://purl.uniprot.org/uniprot/Q38ET6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Peroxisome membrane http://togogenome.org/gene/185431:Tb10.70.6650 ^@ http://purl.uniprot.org/uniprot/Q38CA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.4.5560 ^@ http://purl.uniprot.org/uniprot/Q580P0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.100.0155 ^@ http://purl.uniprot.org/uniprot/Q38CL1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/185431:TB927.1.5170 ^@ http://purl.uniprot.org/uniprot/Q4GY64 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.211.2660 ^@ http://purl.uniprot.org/uniprot/Q38DN8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/185431:Tb10.70.5950 ^@ http://purl.uniprot.org/uniprot/Q38C53 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb10.61.2630 ^@ http://purl.uniprot.org/uniprot/Q388I4 ^@ Similarity ^@ Belongs to the WD repeat SEC13 family. http://togogenome.org/gene/185431:Tb927.7.5090 ^@ http://purl.uniprot.org/uniprot/Q57ZI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/185431:Tb09.211.0700 ^@ http://purl.uniprot.org/uniprot/Q38E87 ^@ Subunit ^@ Homooctamer. Dimer of tetramers. http://togogenome.org/gene/185431:Tb927.8.6060 ^@ http://purl.uniprot.org/uniprot/Q57YK7 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/185431:Tb927.5.1930 ^@ http://purl.uniprot.org/uniprot/Q57ZR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb09.160.1220 ^@ http://purl.uniprot.org/uniprot/Q38FR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.211.2860 ^@ http://purl.uniprot.org/uniprot/Q38DL9 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/185431:Tb10.70.2490 ^@ http://purl.uniprot.org/uniprot/Q38BD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb927.4.2670 ^@ http://purl.uniprot.org/uniprot/D6XFK3 ^@ Similarity ^@ Belongs to the peptidase C15 family. http://togogenome.org/gene/185431:Tb927.8.2160 ^@ http://purl.uniprot.org/uniprot/Q581W6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.61.2130 ^@ http://purl.uniprot.org/uniprot/Q388E8 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. http://togogenome.org/gene/185431:Tb927.3.4720 ^@ http://purl.uniprot.org/uniprot/Q582R3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/185431:Tb09.160.0710 ^@ http://purl.uniprot.org/uniprot/Q38FW8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/185431:Tb09.160.5480 ^@ http://purl.uniprot.org/uniprot/Q38EK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.4090 ^@ http://purl.uniprot.org/uniprot/Q581C9 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/185431:Tb09.211.1820 ^@ http://purl.uniprot.org/uniprot/Q38DX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||DNA polymerase II participates in chromosomal DNA replication.|||Nucleus http://togogenome.org/gene/185431:Tb927.3.4500 ^@ http://purl.uniprot.org/uniprot/Q580J2 ^@ Similarity|||Subunit ^@ Belongs to the class-I fumarase family.|||Homodimer. http://togogenome.org/gene/185431:Tb927.8.5310 ^@ http://purl.uniprot.org/uniprot/Q57UK3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/185431:Tb927.6.850 ^@ http://purl.uniprot.org/uniprot/Q585G1 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/185431:Tb927.2.3930 ^@ http://purl.uniprot.org/uniprot/Q586W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/185431:Tb927.8.3910 ^@ http://purl.uniprot.org/uniprot/Q581B1 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/185431:Tb927.7.4560 ^@ http://purl.uniprot.org/uniprot/D6XIY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/185431:Tb927.7.6040 ^@ http://purl.uniprot.org/uniprot/Q57VK7 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb10.70.2260 ^@ http://purl.uniprot.org/uniprot/Q38BA7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.8.6760 ^@ http://purl.uniprot.org/uniprot/Q57TT7 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/185431:Tb927.7.5970 ^@ http://purl.uniprot.org/uniprot/Q57VL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.6k15.1160 ^@ http://purl.uniprot.org/uniprot/Q38A49 ^@ Similarity ^@ Belongs to the CAP family. http://togogenome.org/gene/185431:Tb10.70.5220 ^@ http://purl.uniprot.org/uniprot/Q38BZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/185431:TB927.1.4740 ^@ http://purl.uniprot.org/uniprot/Q4GYA4 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/185431:Tb927.6.3750 ^@ http://purl.uniprot.org/uniprot/Q585X3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/185431:Tb09.160.2110 ^@ http://purl.uniprot.org/uniprot/Q38FI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the NTC complex (or PRP19-associated complex) (By similarity). The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex reminiscent of a late-stage spliceosome (By similarity). Associates specifically with U5-containing snRNPs.|||Belongs to the CWC21 family.|||Cytoplasm|||Essential protein involved in pre-mRNA cis- and trans-splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate.|||Nucleus http://togogenome.org/gene/185431:Tb927.4.3280 ^@ http://purl.uniprot.org/uniprot/Q584A5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.1130 ^@ http://purl.uniprot.org/uniprot/Q38B23 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/185431:Tb927.5.2850 ^@ http://purl.uniprot.org/uniprot/Q57ZW1 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/185431:Tb10.406.0080 ^@ http://purl.uniprot.org/uniprot/Q389Q0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/185431:Tb10.6k15.2030 ^@ http://purl.uniprot.org/uniprot/Q38AB9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/185431:Tb927.6.4780 ^@ http://purl.uniprot.org/uniprot/Q587E4 ^@ Similarity ^@ Belongs to the ATP-dependent DNA ligase family. http://togogenome.org/gene/185431:Tb927.4.4380 ^@ http://purl.uniprot.org/uniprot/Q57Y42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:TB927.1.3850 ^@ http://purl.uniprot.org/uniprot/Q4GYJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Membrane http://togogenome.org/gene/185431:Tb10.70.4600 ^@ http://purl.uniprot.org/uniprot/Q38BU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/185431:Tb09.211.0910 ^@ http://purl.uniprot.org/uniprot/Q38E65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKZF1/VMS1 family.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.6.700 ^@ http://purl.uniprot.org/uniprot/Q583T3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm|||Mitochondrion|||Monomer. http://togogenome.org/gene/185431:Tb927.8.2530 ^@ http://purl.uniprot.org/uniprot/Q57XD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/185431:Tb10.6k15.3050 ^@ http://purl.uniprot.org/uniprot/Q38AK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/185431:Tb927.5.4300 ^@ http://purl.uniprot.org/uniprot/Q57Z19 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/185431:Tb927.4.2020 ^@ http://purl.uniprot.org/uniprot/Q583J1 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/185431:Tb10.70.0770 ^@ http://purl.uniprot.org/uniprot/Q38AZ6 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/185431:Tb10.389.0430 ^@ http://purl.uniprot.org/uniprot/Q388U2 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.8.3100 ^@ http://purl.uniprot.org/uniprot/Q57W63 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/185431:Tb927.6.3630 ^@ http://purl.uniprot.org/uniprot/Q585W1 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/185431:Tb927.8.2310 ^@ http://purl.uniprot.org/uniprot/Q57XF8 ^@ Similarity ^@ Belongs to the V-ATPase G subunit family. http://togogenome.org/gene/185431:Tb10.6k15.3280 ^@ http://purl.uniprot.org/uniprot/Q38AM4 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/185431:TB927.1.580 ^@ http://purl.uniprot.org/uniprot/Q4GZF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/185431:Tb927.8.3560 ^@ http://purl.uniprot.org/uniprot/Q580X6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Involved in processing of minicircle Okazaki fragments.|||Mitochondrion|||Monomer. http://togogenome.org/gene/185431:Tb927.6.2960 ^@ http://purl.uniprot.org/uniprot/Q583N8 ^@ Function|||Similarity|||Subunit ^@ AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.|||Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.|||Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/185431:Tb927.2.2450 ^@ http://purl.uniprot.org/uniprot/Q586L7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/185431:Tb10.70.4740 ^@ http://purl.uniprot.org/uniprot/Q38BV6 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/185431:Tb927.7.2080 ^@ http://purl.uniprot.org/uniprot/Q57V03 ^@ Similarity ^@ In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family. http://togogenome.org/gene/185431:Tb09.211.1320 ^@ http://purl.uniprot.org/uniprot/Q38E23 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/185431:Tb927.3.1790 ^@ http://purl.uniprot.org/uniprot/Q57ZD2 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/185431:Tb927.6.1250 ^@ http://purl.uniprot.org/uniprot/Q585C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/185431:Tb10.6k15.3340 ^@ http://purl.uniprot.org/uniprot/Q38AM9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/185431:Tb927.4.2000 ^@ http://purl.uniprot.org/uniprot/Q583J3 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/185431:Tb927.3.2400 ^@ http://purl.uniprot.org/uniprot/Q582V3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/185431:Tb927.3.4850 ^@ http://purl.uniprot.org/uniprot/Q582Q0 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/185431:TB927.1.630 ^@ http://purl.uniprot.org/uniprot/Q4GZF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.3.860 ^@ http://purl.uniprot.org/uniprot/Q57WW9 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/185431:Tb927.3.4790 ^@ http://purl.uniprot.org/uniprot/Q582Q6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/185431:Tb927.6.3310 ^@ http://purl.uniprot.org/uniprot/Q584X4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb10.70.3000 ^@ http://purl.uniprot.org/uniprot/Q38BH5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/185431:Tb927.6.4460 ^@ http://purl.uniprot.org/uniprot/Q587A7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/185431:Tb09.244.1580 ^@ http://purl.uniprot.org/uniprot/Q38CQ2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.6.4410 ^@ http://purl.uniprot.org/uniprot/Q587A7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/185431:Tb927.7.5900 ^@ http://purl.uniprot.org/uniprot/Q582K5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/185431:Tb927.2.4740 ^@ http://purl.uniprot.org/uniprot/Q586R9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/185431:Tb927.7.2360 ^@ http://purl.uniprot.org/uniprot/Q57XN8 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/185431:Tb09.160.0680 ^@ http://purl.uniprot.org/uniprot/Q38FX1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/185431:Tb927.4.3080 ^@ http://purl.uniprot.org/uniprot/Q583Y5 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/185431:Tb927.8.3400 ^@ http://purl.uniprot.org/uniprot/Q57YX3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/185431:Tb10.6k15.2620 ^@ http://purl.uniprot.org/uniprot/Q38AH1 ^@ Cofactor|||Developmental Stage|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit (Probable). May also use Mg(2+) and Zn(2+) (Probable).|||Catalyzes the interconversion of 2-phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA).|||Cytoplasm|||Expressed in the procyclic and bloodstream stages (at protein level).|||Monomer.|||RNAi-mediated knockdown causes a severe reduction in phosphoglycerate mutase activity and reduces the growth of the procyclic form of the parasite. http://togogenome.org/gene/185431:Tb927.6.3090 ^@ http://purl.uniprot.org/uniprot/Q583M5 ^@ Similarity ^@ Belongs to the TOG/XMAP215 family. http://togogenome.org/gene/185431:Tb927.8.5570 ^@ http://purl.uniprot.org/uniprot/Q57X25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69.2) family.|||Involved in cellular auxin homeostasis by regulating auxin metabolism. Regulates intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signaling.|||Membrane http://togogenome.org/gene/185431:Tb927.7.1120 ^@ http://purl.uniprot.org/uniprot/D6XK30 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/185431:Tb927.8.5140 ^@ http://purl.uniprot.org/uniprot/Q57UI6 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/185431:Tb10.61.2040 ^@ http://purl.uniprot.org/uniprot/Q388E0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/185431:Tb10.6k15.1850 ^@ http://purl.uniprot.org/uniprot/Q38AA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/185431:Tb09.211.4513 ^@ http://purl.uniprot.org/uniprot/Q38D58 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KMP-11 family.|||Monomer.|||cytoskeleton http://togogenome.org/gene/185431:Tb927.6.1050 ^@ http://purl.uniprot.org/uniprot/Q585E2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb927.7.7530 ^@ http://purl.uniprot.org/uniprot/Q57TZ0 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb09.211.0050 ^@ http://purl.uniprot.org/uniprot/Q38EF6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/185431:TB927.1.2330 ^@ http://purl.uniprot.org/uniprot/Q4GYY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/185431:TB927.1.5300 ^@ http://purl.uniprot.org/uniprot/Q4GY52 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.211.1510 ^@ http://purl.uniprot.org/uniprot/Q38E05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.8.590 ^@ http://purl.uniprot.org/uniprot/Q57YH1 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/185431:Tb10.61.2840 ^@ http://purl.uniprot.org/uniprot/Q388J5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/185431:Tb927.8.1410 ^@ http://purl.uniprot.org/uniprot/Q580I2 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/185431:Tb927.4.3570 ^@ http://purl.uniprot.org/uniprot/Q585J3 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/185431:Tb10.6k15.0550 ^@ http://purl.uniprot.org/uniprot/Q38A00 ^@ Cofactor|||Similarity ^@ Belongs to the alternative oxidase family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/185431:Tb927.6.5240 ^@ http://purl.uniprot.org/uniprot/Q583L8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.1750 ^@ http://purl.uniprot.org/uniprot/Q57V35 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/185431:Tb927.6.1260 ^@ http://purl.uniprot.org/uniprot/Q585C1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb09.160.0260 ^@ http://purl.uniprot.org/uniprot/Q38G16 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.v1.0640 ^@ http://purl.uniprot.org/uniprot/Q38DN9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/185431:Tb10.6k15.3600 ^@ http://purl.uniprot.org/uniprot/Q38AQ2 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/185431:Tb927.3.1220 ^@ http://purl.uniprot.org/uniprot/D6XD30|||http://purl.uniprot.org/uniprot/Q57XV5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX1 family.|||Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.|||Forms a heterodimer with a member of the SLX4 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.1100 ^@ http://purl.uniprot.org/uniprot/Q38B20 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/185431:Tb927.3.590 ^@ http://purl.uniprot.org/uniprot/Q57TQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.1750 ^@ http://purl.uniprot.org/uniprot/Q38DX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.8.3140 ^@ http://purl.uniprot.org/uniprot/Q57YZ9 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Mitochondrion matrix|||NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/185431:Tb927.4.4030 ^@ http://purl.uniprot.org/uniprot/Q57Y07 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/185431:Tb927.8.6740 ^@ http://purl.uniprot.org/uniprot/Q57TT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/185431:Tb09.211.3200 ^@ http://purl.uniprot.org/uniprot/Q38DI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.3130 ^@ http://purl.uniprot.org/uniprot/Q57W60 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/185431:Tb10.61.2440 ^@ http://purl.uniprot.org/uniprot/Q388G9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/185431:Tb10.61.1830 ^@ http://purl.uniprot.org/uniprot/Q388C4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/185431:Tb927.8.5510 ^@ http://purl.uniprot.org/uniprot/Q57X31 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/185431:Tb927.6.5740 ^@ http://purl.uniprot.org/uniprot/Q583L3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.6k15.2580 ^@ http://purl.uniprot.org/uniprot/Q38AG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.100.0120 ^@ http://purl.uniprot.org/uniprot/Q38CL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. http://togogenome.org/gene/185431:Tb09.211.0090 ^@ http://purl.uniprot.org/uniprot/Q38EF2 ^@ Similarity ^@ Belongs to the TRAPPC13 family. http://togogenome.org/gene/185431:Tb10.61.2870 ^@ http://purl.uniprot.org/uniprot/Q388J8 ^@ Similarity ^@ Belongs to the CEP43 family.|||Belongs to the TBCC family. http://togogenome.org/gene/185431:Tb927.4.2700 ^@ http://purl.uniprot.org/uniprot/D6XFK6 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/185431:Tb927.7.6500 ^@ http://purl.uniprot.org/uniprot/Q57Y76 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.1620 ^@ http://purl.uniprot.org/uniprot/Q57WN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/185431:Tb09.160.4240 ^@ http://purl.uniprot.org/uniprot/Q38EY2 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/185431:Tb10.70.7440 ^@ http://purl.uniprot.org/uniprot/Q38CG3 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/185431:Tb10.70.4380 ^@ http://purl.uniprot.org/uniprot/Q38BT4 ^@ Function|||Subcellular Location Annotation ^@ Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb10.389.1850 ^@ http://purl.uniprot.org/uniprot/Q389E9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/185431:Tb927.3.5520 ^@ http://purl.uniprot.org/uniprot/Q580S3 ^@ Similarity ^@ Belongs to the proteasome subunit S2 family. http://togogenome.org/gene/185431:Tb927.8.2630 ^@ http://purl.uniprot.org/uniprot/Q57XC6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.4.4290 ^@ http://purl.uniprot.org/uniprot/Q57Y33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.4.5310 ^@ http://purl.uniprot.org/uniprot/Q580Q4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.3.830 ^@ http://purl.uniprot.org/uniprot/Q57WW6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Mitochondrion|||Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/185431:Tb927.5.650 ^@ http://purl.uniprot.org/uniprot/Q57VF3 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.8.3650 ^@ http://purl.uniprot.org/uniprot/Q580Y5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.4.690 ^@ http://purl.uniprot.org/uniprot/Q57ZZ7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/185431:Tb09.211.1020 ^@ http://purl.uniprot.org/uniprot/Q38E54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Bidirectional lipid ethanolaminephosphotransferase capable of converting phosphatidylethanolamine (PE) and ceramide to ethanolamine-phosphorylceramide (EPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoethanolamine acceptors. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target (By similarity).|||Membrane http://togogenome.org/gene/185431:Tb927.8.5250 ^@ http://purl.uniprot.org/uniprot/Q57UJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/185431:Tb927.8.4290 ^@ http://purl.uniprot.org/uniprot/Q57W06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/185431:Tb927.4.2720 ^@ http://purl.uniprot.org/uniprot/D6XFK8 ^@ Domain|||Function|||Similarity ^@ Belongs to the DEAD box helicase family.|||RNA helicase.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/185431:Tb09.211.1030 ^@ http://purl.uniprot.org/uniprot/Q38E53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Bidirectional lipid inositolphosphotransferase capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoinositol acceptors. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target (By similarity).|||Membrane http://togogenome.org/gene/185431:Tb09.160.4600 ^@ http://purl.uniprot.org/uniprot/Q38EU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.70.0970 ^@ http://purl.uniprot.org/uniprot/Q38B11 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb10.406.0290 ^@ http://purl.uniprot.org/uniprot/Q389R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Membrane http://togogenome.org/gene/185431:TB927.1.1060 ^@ http://purl.uniprot.org/uniprot/Q4GZB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/185431:Tb10.61.1040 ^@ http://purl.uniprot.org/uniprot/Q387X6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/185431:Tb09.211.4511 ^@ http://purl.uniprot.org/uniprot/Q38D58 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KMP-11 family.|||Monomer.|||cytoskeleton http://togogenome.org/gene/185431:Tb10.61.1030 ^@ http://purl.uniprot.org/uniprot/Q387X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP11 family.|||nucleolus http://togogenome.org/gene/185431:Tb09.211.1210 ^@ http://purl.uniprot.org/uniprot/Q38E34 ^@ Similarity ^@ Belongs to the RecA family. DMC1 subfamily. http://togogenome.org/gene/185431:Tb927.4.450 ^@ http://purl.uniprot.org/uniprot/Q57UT0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. http://togogenome.org/gene/185431:Tb09.211.0860 ^@ http://purl.uniprot.org/uniprot/Q38E70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/185431:Tb10.406.0380 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.3.800 ^@ http://purl.uniprot.org/uniprot/Q57WW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCC1 family.|||Membrane http://togogenome.org/gene/185431:Tb927.7.3220 ^@ http://purl.uniprot.org/uniprot/Q57YD2 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/185431:Tb09.160.3270 ^@ http://purl.uniprot.org/uniprot/Q38F76 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G (By similarity). http://togogenome.org/gene/185431:Tb927.6.5120 ^@ http://purl.uniprot.org/uniprot/Q586I4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||P1 and P2 exist as dimers at the large ribosomal subunit.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/185431:Tb09.160.5580 ^@ http://purl.uniprot.org/uniprot/Q38EI9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/185431:TB927.1.1150 ^@ http://purl.uniprot.org/uniprot/Q4GZA3 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/185431:Tb927.4.1800 ^@ http://purl.uniprot.org/uniprot/Q581Q1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/185431:Tb10.406.0600 ^@ http://purl.uniprot.org/uniprot/Q389U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Nucleus http://togogenome.org/gene/185431:Tb927.8.5490 ^@ http://purl.uniprot.org/uniprot/Q57X33 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/185431:Tb927.2.2060 ^@ http://purl.uniprot.org/uniprot/Q586J1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.7730 ^@ http://purl.uniprot.org/uniprot/Q57V92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.160.0630 ^@ http://purl.uniprot.org/uniprot/Q38FX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.3.1240 ^@ http://purl.uniprot.org/uniprot/Q57XV7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb10.61.0690 ^@ http://purl.uniprot.org/uniprot/Q387U9 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/185431:Tb927.7.1800 ^@ http://purl.uniprot.org/uniprot/Q57V30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.6k15.3990 ^@ http://purl.uniprot.org/uniprot/Q38AS9 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/185431:Tb927.6.4690 ^@ http://purl.uniprot.org/uniprot/Q587D5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/185431:Tb927.7.6900 ^@ http://purl.uniprot.org/uniprot/Q57XR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/185431:Tb927.6.3940 ^@ http://purl.uniprot.org/uniprot/Q585Z2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.5.660 ^@ http://purl.uniprot.org/uniprot/Q57VF4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.440 ^@ http://purl.uniprot.org/uniprot/Q57UT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFB11 subunit family.|||Membrane http://togogenome.org/gene/185431:Tb927.4.1480 ^@ http://purl.uniprot.org/uniprot/Q581T3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb09.211.0190 ^@ http://purl.uniprot.org/uniprot/Q38EE2 ^@ Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. http://togogenome.org/gene/185431:Tb10.6k15.1570 ^@ http://purl.uniprot.org/uniprot/Q38A84 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/185431:Tb10.406.0260 ^@ http://purl.uniprot.org/uniprot/Q389R3 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/185431:Tb927.4.1720 ^@ http://purl.uniprot.org/uniprot/Q581Q9 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/185431:Tb927.6.220 ^@ http://purl.uniprot.org/uniprot/Q581D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.4150 ^@ http://purl.uniprot.org/uniprot/Q581D5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.26.0780 ^@ http://purl.uniprot.org/uniprot/Q389L6 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/185431:Tb09.142.0450 ^@ http://purl.uniprot.org/uniprot/Q38G28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.3.4000 ^@ http://purl.uniprot.org/uniprot/Q57WD6 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/185431:Tb927.6.1900 ^@ http://purl.uniprot.org/uniprot/Q585M1 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/185431:Tb927.8.3120 ^@ http://purl.uniprot.org/uniprot/Q57W61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/185431:Tb10.389.0160 ^@ http://purl.uniprot.org/uniprot/Q388S0 ^@ Similarity ^@ Belongs to the WD repeat PWP2 family. http://togogenome.org/gene/185431:Tb927.3.1360 ^@ http://purl.uniprot.org/uniprot/Q57XW9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/185431:Tb927.6.2280 ^@ http://purl.uniprot.org/uniprot/Q584S2 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/185431:Tb927.5.2750 ^@ http://purl.uniprot.org/uniprot/Q57ZV1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/185431:Tb10.6k15.0490 ^@ http://purl.uniprot.org/uniprot/Q389Z4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/185431:Tb10.70.2140 ^@ http://purl.uniprot.org/uniprot/Q38B94 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/185431:Tb09.160.0500 ^@ http://purl.uniprot.org/uniprot/Q38FZ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.5.4200 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.70.0250 ^@ http://purl.uniprot.org/uniprot/Q38AV2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb927.3.1470 ^@ http://purl.uniprot.org/uniprot/Q57XY0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.2670 ^@ http://purl.uniprot.org/uniprot/Q57XC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.5.3670 ^@ http://purl.uniprot.org/uniprot/Q57U99 ^@ Similarity ^@ Belongs to the XPF family. http://togogenome.org/gene/185431:TB927.1.2110 ^@ http://purl.uniprot.org/uniprot/Q4GZ10 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.7.100 ^@ http://purl.uniprot.org/uniprot/Q57U38 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.3230 ^@ http://purl.uniprot.org/uniprot/Q57V63 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/185431:Tb927.5.2090 ^@ http://purl.uniprot.org/uniprot/Q57ZS8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb09.211.3560 ^@ http://purl.uniprot.org/uniprot/Q38DE9 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/185431:Tb927.5.5240 ^@ http://purl.uniprot.org/uniprot/Q57UD6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.680 ^@ http://purl.uniprot.org/uniprot/Q57YG2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/185431:Tb09.211.4190 ^@ http://purl.uniprot.org/uniprot/Q38D90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP53 family.|||nucleolus|||nucleoplasm http://togogenome.org/gene/185431:Tb927.7.3520 ^@ http://purl.uniprot.org/uniprot/Q57WG7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.2.2920 ^@ http://purl.uniprot.org/uniprot/Q587G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.5.2980 ^@ http://purl.uniprot.org/uniprot/Q57ZX4 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/185431:Tb09.211.0450 ^@ http://purl.uniprot.org/uniprot/Q38EB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.8.6150 ^@ http://purl.uniprot.org/uniprot/Q57YL6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/185431:Tb927.8.3550 ^@ http://purl.uniprot.org/uniprot/Q580X5 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/185431:Tb927.3.4200 ^@ http://purl.uniprot.org/uniprot/Q580M2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.2.2240 ^@ http://purl.uniprot.org/uniprot/Q586K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/185431:Tb10.70.5260 ^@ http://purl.uniprot.org/uniprot/Q38C02 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.7.5490 ^@ http://purl.uniprot.org/uniprot/Q582G4 ^@ Caution|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Arginine methyltransferase that specifically catalyzes the formation of omega-N monomethylarginine (MMA). Has activity toward multiple substrates in vitro. Able to mediate the arginine methylation of histones and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Compared to PRMT7 orthologs in other metazoans, it is shorter and lacks the C-terminal part.|||Cytoplasm|||Expressed during both bloodstream (BF) and procyclic insect (PF) life cycle stages.|||Present in large multiprotein complexes. http://togogenome.org/gene/185431:Tb927.5.3400 ^@ http://purl.uniprot.org/uniprot/Q57Z55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/185431:Tb09.160.2050 ^@ http://purl.uniprot.org/uniprot/Q38FI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DeSI family.|||Belongs to the glycosyl hydrolase 85 family.|||cytosol http://togogenome.org/gene/185431:Tb10.70.1440 ^@ http://purl.uniprot.org/uniprot/P86936 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family. PIGB subfamily.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).|||The protozoan parasite evades the immune response of mammalian hosts and digestion in the gut of the insect vector by means of its coat proteins tethered to the cell surface via GPI-anchors. GPI10 is essential for growth of mammalian stage bloodstream form, while procyclic form (insect stage parasites) are viable but grow slower, suggesting that inhibition of GPI synthesis may be an effective chemotherapy against African trypanosomiasis (By similarity). http://togogenome.org/gene/185431:Tb927.7.1500 ^@ http://purl.uniprot.org/uniprot/Q57WQ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. http://togogenome.org/gene/185431:Tb927.6.520 ^@ http://purl.uniprot.org/uniprot/Q581G0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Major surface antigen of procyclic forms.|||Membrane http://togogenome.org/gene/185431:Tb10.26.0750 ^@ http://purl.uniprot.org/uniprot/Q389L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS41 family.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.5.3120 ^@ http://purl.uniprot.org/uniprot/Q57Z81 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/185431:Tb927.5.4460 ^@ http://purl.uniprot.org/uniprot/Q57Z03 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Nucleus|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity).|||The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity). http://togogenome.org/gene/185431:Tb927.5.4180 ^@ http://purl.uniprot.org/uniprot/Q57Z31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.70.5680 ^@ http://purl.uniprot.org/uniprot/Q38C34 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/185431:Tb927.4.1810 ^@ http://purl.uniprot.org/uniprot/Q581Q0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/185431:Tb927.8.5040 ^@ http://purl.uniprot.org/uniprot/Q57UH6 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/185431:Tb10.6k15.2950 ^@ http://purl.uniprot.org/uniprot/Q38AJ7 ^@ Similarity ^@ Belongs to the TMA16 family. http://togogenome.org/gene/185431:Tb09.160.3110 ^@ http://purl.uniprot.org/uniprot/Q38F91 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/185431:Tb10.61.1190 ^@ http://purl.uniprot.org/uniprot/Q387Y2 ^@ Similarity ^@ Belongs to the TBCC family. http://togogenome.org/gene/185431:Tb927.2.6310 ^@ http://purl.uniprot.org/uniprot/Q586M6 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb927.3.3000 ^@ http://purl.uniprot.org/uniprot/Q57ZL2 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IFT56 family.|||Component of the IFT complex B.|||Component of the intraflagellar transport (IFT) complex required for transport of proteins in the motile cilium.|||Defects in new flagellum formation.|||flagellum http://togogenome.org/gene/185431:TB927.1.880 ^@ http://purl.uniprot.org/uniprot/Q4GZD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the midasin family.|||Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.|||nucleolus|||nucleoplasm http://togogenome.org/gene/185431:Tb927.8.3310 ^@ http://purl.uniprot.org/uniprot/Q57YY2 ^@ Similarity ^@ Belongs to the ELP3 family. http://togogenome.org/gene/185431:Tb927.3.1370 ^@ http://purl.uniprot.org/uniprot/Q57XX0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/185431:Tb10.70.2970 ^@ http://purl.uniprot.org/uniprot/Q38BH2 ^@ Similarity ^@ Belongs to the UQCRB/QCR7 family. http://togogenome.org/gene/185431:Tb09.211.0680 ^@ http://purl.uniprot.org/uniprot/Q38E89 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/185431:Tb927.3.2900 ^@ http://purl.uniprot.org/uniprot/Q57ZM2 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/185431:Tb927.6.1640 ^@ http://purl.uniprot.org/uniprot/Q585P6 ^@ Similarity ^@ Belongs to the nuclease type I family. http://togogenome.org/gene/185431:Tb927.8.3920 ^@ http://purl.uniprot.org/uniprot/Q581B2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MET18/MMS19 family.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus http://togogenome.org/gene/185431:Tb927.2.3190 ^@ http://purl.uniprot.org/uniprot/Q587F6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/185431:Tb927.4.4210 ^@ http://purl.uniprot.org/uniprot/Q57Y25 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb09.160.4200 ^@ http://purl.uniprot.org/uniprot/Q38EY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||P1 and P2 exist as dimers at the large ribosomal subunit.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/185431:Tb927.4.5410 ^@ http://purl.uniprot.org/uniprot/Q580P5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.3010 ^@ http://purl.uniprot.org/uniprot/Q57YB1 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/185431:Tb10.6k15.3470 ^@ http://purl.uniprot.org/uniprot/Q38AP1 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/185431:Tb927.6.2170 ^@ http://purl.uniprot.org/uniprot/Q584T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/185431:Tb927.6.3000 ^@ http://purl.uniprot.org/uniprot/Q583N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Membrane http://togogenome.org/gene/185431:Tb10.70.3220 ^@ http://purl.uniprot.org/uniprot/Q38BJ5 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/185431:Tb927.8.130 ^@ http://purl.uniprot.org/uniprot/Q57XI8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.6040 ^@ http://purl.uniprot.org/uniprot/Q38C62 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/185431:Tb09.142.0240 ^@ http://purl.uniprot.org/uniprot/Q38G41 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.70.7520 ^@ http://purl.uniprot.org/uniprot/Q38CH1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/185431:Tb927.8.5460 ^@ http://purl.uniprot.org/uniprot/Q57UL8 ^@ Function|||Similarity ^@ Belongs to the calflagin family.|||May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form. http://togogenome.org/gene/185431:Tb927.8.1240 ^@ http://purl.uniprot.org/uniprot/Q57VN1 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/185431:TB927.1.4050 ^@ http://purl.uniprot.org/uniprot/Q4GYH2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb927.8.4390 ^@ http://purl.uniprot.org/uniprot/Q57VZ6 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/185431:Tb927.3.4410 ^@ http://purl.uniprot.org/uniprot/Q580K1 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/185431:Tb10.406.0330 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.389.0110 ^@ http://purl.uniprot.org/uniprot/Q388R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/185431:Tb09.244.0470 ^@ http://purl.uniprot.org/uniprot/Q38CP0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.244.2580 ^@ http://purl.uniprot.org/uniprot/Q38CW8 ^@ Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily. http://togogenome.org/gene/185431:Tb927.8.1800 ^@ http://purl.uniprot.org/uniprot/Q582A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/185431:Tb927.5.2700 ^@ http://purl.uniprot.org/uniprot/Q57ZU6 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/185431:Tb927.5.2800 ^@ http://purl.uniprot.org/uniprot/Q57ZV6 ^@ Similarity ^@ Belongs to the RNase Z family. http://togogenome.org/gene/185431:Tb927.3.5440 ^@ http://purl.uniprot.org/uniprot/Q580T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/185431:Tb927.8.7050 ^@ http://purl.uniprot.org/uniprot/Q57YR2 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/185431:Tb927.5.2940 ^@ http://purl.uniprot.org/uniprot/Q57ZX0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:TB927.1.5060 ^@ http://purl.uniprot.org/uniprot/Q4GY74 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.406.0170 ^@ http://purl.uniprot.org/uniprot/Q389Q6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.8.4580 ^@ http://purl.uniprot.org/uniprot/Q57UZ3 ^@ Similarity ^@ Belongs to the CFAP45 family. http://togogenome.org/gene/185431:Tb927.4.5290 ^@ http://purl.uniprot.org/uniprot/Q584H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb09.211.3870 ^@ http://purl.uniprot.org/uniprot/Q38DC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.211.2410 ^@ http://purl.uniprot.org/uniprot/Q38DR5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.7.1300 ^@ http://purl.uniprot.org/uniprot/Q57WS0 ^@ Similarity ^@ Belongs to the protein disulfide isomerase family. http://togogenome.org/gene/185431:TB927.1.2880 ^@ http://purl.uniprot.org/uniprot/Q4GYT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.|||Membrane http://togogenome.org/gene/185431:Tb927.8.7460 ^@ http://purl.uniprot.org/uniprot/Q57YU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.8.6180 ^@ http://purl.uniprot.org/uniprot/Q57YL9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/185431:Tb927.5.2530 ^@ http://purl.uniprot.org/uniprot/Q582B4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/185431:Tb927.6.4060 ^@ http://purl.uniprot.org/uniprot/Q586A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Membrane http://togogenome.org/gene/185431:Tb10.6k15.2040 ^@ http://purl.uniprot.org/uniprot/Q38AC0 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/185431:Tb10.70.5150 ^@ http://purl.uniprot.org/uniprot/Q38BZ2 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/185431:Tb927.4.3560 ^@ http://purl.uniprot.org/uniprot/Q585J4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb927.5.4730 ^@ http://purl.uniprot.org/uniprot/Q57X39 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.6k15.3670 ^@ http://purl.uniprot.org/uniprot/Q38AQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||nuclear pore complex http://togogenome.org/gene/185431:Tb927.4.3810 ^@ http://purl.uniprot.org/uniprot/Q583H5 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/185431:Tb927.3.910 ^@ http://purl.uniprot.org/uniprot/D6XD01 ^@ Function|||Similarity ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. http://togogenome.org/gene/185431:Tb927.4.4600 ^@ http://purl.uniprot.org/uniprot/Q583E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.3.3610 ^@ http://purl.uniprot.org/uniprot/Q57W97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Peroxisome matrix|||cytosol http://togogenome.org/gene/185431:Tb10.6k15.2840 ^@ http://purl.uniprot.org/uniprot/Q38AJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb10.61.0150 ^@ http://purl.uniprot.org/uniprot/Q387Q3 ^@ Similarity ^@ Belongs to the IMPDH/GMPR family. http://togogenome.org/gene/185431:Tb927.5.3610 ^@ http://purl.uniprot.org/uniprot/Q57UA5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 3 (AP-3) is a heterotetramer.|||Belongs to the adaptor complexes large subunit family.|||Golgi apparatus http://togogenome.org/gene/185431:Tb927.7.3360 ^@ http://purl.uniprot.org/uniprot/Q57WF1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/185431:Tb927.8.2850 ^@ http://purl.uniprot.org/uniprot/Q57W87 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/185431:Tb927.8.4040 ^@ http://purl.uniprot.org/uniprot/Q581C4 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/185431:Tb927.4.320 ^@ http://purl.uniprot.org/uniprot/Q57UU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/185431:Tb10.6k15.3030 ^@ http://purl.uniprot.org/uniprot/Q38AK2 ^@ Similarity ^@ Belongs to the AAA ATPase family.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb09.160.3820 ^@ http://purl.uniprot.org/uniprot/Q38F23 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/185431:Tb09.211.2630 ^@ http://purl.uniprot.org/uniprot/Q38DP2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/185431:Tb927.3.5100 ^@ http://purl.uniprot.org/uniprot/Q580W5 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent 3'-5' DNA helicase, component of the general transcription factor IIH (TFIIH) core complex, involved in spliced leader RNA (SL RNA) gene transcription by RNA polymerase II (PubMed:17259543). TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB is required for promoter opening and promoter escape (By similarity).|||Belongs to the helicase family. RAD25/XPB subfamily.|||Component of the 7-subunit TFIIH core complex composed of XPB, XPD, SSL1, TFB1, TFB2, TFB4 and TFB5. http://togogenome.org/gene/185431:TB927.1.2450 ^@ http://purl.uniprot.org/uniprot/Q4GYX7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/185431:Tb10.61.2880 ^@ http://purl.uniprot.org/uniprot/Q388J9 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/185431:Tb10.70.0120 ^@ http://purl.uniprot.org/uniprot/Q38AU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/185431:Tb10.6k15.0980 ^@ http://purl.uniprot.org/uniprot/Q38A33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb09.160.2380 ^@ http://purl.uniprot.org/uniprot/Q38FF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.7.2880 ^@ http://purl.uniprot.org/uniprot/Q57YA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.8.7280 ^@ http://purl.uniprot.org/uniprot/Q57YT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.1680 ^@ http://purl.uniprot.org/uniprot/Q585P3 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Subcellular Location Annotation|||Subunit ^@ Component of the REH2-associated complex (REH2C) composed of helicase REH2, associated factors H2F1 and H2F2, and mRNAs at various editing stages; the formation of the complex is RNA-independent (PubMed:26769962, PubMed:31034523). Within the complex, interacts with REH2; the interaction is direct (PubMed:26769962). Interacts with various editing complexes including the RNA editing core (RECC) complex, the gRNA-binding (GRBC) complex (also known as the MRB1 complex) and the RNA editing mediator (REMC) complex (PubMed:26769962, PubMed:31034523).|||Expressed at the procyclic stage (at protein level).|||Mitochondrion|||Plays an important role in mitochondrial mRNA editing by promoting the assembly of the mRNA editosome (PubMed:26769962, PubMed:31034523). Facilitates the recruitment of mRNA to the REH2C complex and promotes the interaction between various editing complexes including REH2C, GRBC, REMC and RECC complexes (PubMed:26769962, PubMed:31034523).|||RNAi-mediated knockdown at the procyclic stage causes a reduction in mitochondrial mRNA editing (PubMed:26769962). Formation of the REH2C complex is not affected but REH2C complex association with the GRBC, REMC, RECC complexes and with and pre-mRNA is impaired (PubMed:26769962). Integrity of the GRBC complex is not affected but GRBC complex association with the RECC complex and pre-mRNA is reduced (PubMed:26769962). Causes a slight decrease in REH2 protein levels (PubMed:26769962, PubMed:31034523). Does not affect the RNA unwinding activity of the REH2C complex (PubMed:26769962). http://togogenome.org/gene/185431:Tb927.5.3790 ^@ http://purl.uniprot.org/uniprot/Q57U87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.7.1130 ^@ http://purl.uniprot.org/uniprot/D6XK31 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/185431:Tb927.6.3100 ^@ http://purl.uniprot.org/uniprot/Q583M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/185431:Tb927.8.6320 ^@ http://purl.uniprot.org/uniprot/Q57YN3 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/185431:Tb09.160.4620 ^@ http://purl.uniprot.org/uniprot/Q38EU6 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/185431:Tb927.2.5750 ^@ http://purl.uniprot.org/uniprot/Q586D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/185431:Tb927.6.1950 ^@ http://purl.uniprot.org/uniprot/Q585L6 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/185431:Tb927.4.5460 ^@ http://purl.uniprot.org/uniprot/Q580P2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.2740 ^@ http://purl.uniprot.org/uniprot/D6XFL0 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/185431:Tb927.8.4540 ^@ http://purl.uniprot.org/uniprot/Q57UZ7 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ataxin-2 family.|||Expressed in the procyclic and bloodstream forms (at protein level).|||Forms a complex composed of at least MKT1, PBP1, XAC1 and LSM12 (PubMed:32532821). Forms a complex composed of at least MKT1L, PBP1, XAC1 and LSM12 (PubMed:32532821). Within the complex, interacts with MKT1 (via C-terminus); the interaction is direct (PubMed:24470144, PubMed:32532821). Interacts (via C-terminus) with ZC3H11; the interaction is direct (PubMed:24470144).|||Involved in post-transcriptional regulation of gene expression (PubMed:24470144). Promotes mRNA stabilization by bridging poly(A)-binding protein to mRNAs (PubMed:24470144).|||Stress granule|||cytosol http://togogenome.org/gene/185431:Tb10.6k15.1220 ^@ http://purl.uniprot.org/uniprot/Q38A55 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb927.4.5030 ^@ http://purl.uniprot.org/uniprot/Q584K2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/185431:Tb10.70.3290 ^@ http://purl.uniprot.org/uniprot/Q38BK1 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. http://togogenome.org/gene/185431:Tb927.7.4110 ^@ http://purl.uniprot.org/uniprot/Q57UP1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.6.1000 ^@ http://purl.uniprot.org/uniprot/Q585E2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/185431:Tb927.3.2980 ^@ http://purl.uniprot.org/uniprot/Q57ZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb927.3.2280 ^@ http://purl.uniprot.org/uniprot/Q582U1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/185431:Tb927.6.280 ^@ http://purl.uniprot.org/uniprot/Q581E1 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.8.6950 ^@ http://purl.uniprot.org/uniprot/Q57YQ2 ^@ Similarity ^@ Belongs to the GAMAD family. http://togogenome.org/gene/185431:Tb927.8.7380 ^@ http://purl.uniprot.org/uniprot/Q57YU0 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/185431:Tb927.3.870 ^@ http://purl.uniprot.org/uniprot/Q57WX0 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/185431:Tb10.61.1820 ^@ http://purl.uniprot.org/uniprot/Q388C4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/185431:Tb09.160.3880 ^@ http://purl.uniprot.org/uniprot/Q38F18 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb10.70.1370 ^@ http://purl.uniprot.org/uniprot/Q38B42 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/185431:Tb927.8.7140 ^@ http://purl.uniprot.org/uniprot/Q57YS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb10.05.0010 ^@ http://purl.uniprot.org/uniprot/Q388P2 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/185431:Tb09.160.5550 ^@ http://purl.uniprot.org/uniprot/Q38EJ3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb10.6k15.0410 ^@ http://purl.uniprot.org/uniprot/P50885 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL18 family.|||Cytoplasm http://togogenome.org/gene/185431:Tb10.61.0980 ^@ http://purl.uniprot.org/uniprot/Q387X2 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/185431:Tb927.3.4960 ^@ http://purl.uniprot.org/uniprot/Q582P0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb10.70.6340 ^@ http://purl.uniprot.org/uniprot/Q38C84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/185431:Tb927.4.3850 ^@ http://purl.uniprot.org/uniprot/Q583H9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/185431:Tb927.4.2730 ^@ http://purl.uniprot.org/uniprot/D6XFK9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb09.244.2330 ^@ http://purl.uniprot.org/uniprot/Q38CU4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.550 ^@ http://purl.uniprot.org/uniprot/Q57YH5 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/185431:Tb927.3.3200 ^@ http://purl.uniprot.org/uniprot/Q57V66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/185431:Tb927.7.390 ^@ http://purl.uniprot.org/uniprot/Q57U15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.5.1830 ^@ http://purl.uniprot.org/uniprot/Q57ZQ2 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/185431:Tb09.211.3955 ^@ http://purl.uniprot.org/uniprot/Q38DB3 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/185431:Tb09.160.2550 ^@ http://purl.uniprot.org/uniprot/Q38FD9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/185431:Tb10.61.0570 ^@ http://purl.uniprot.org/uniprot/Q387U0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.3.1380 ^@ http://purl.uniprot.org/uniprot/Q57XX1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/185431:Tb927.6.200 ^@ http://purl.uniprot.org/uniprot/Q581D6 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.8.6930 ^@ http://purl.uniprot.org/uniprot/Q57YQ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:TB927.1.3180 ^@ http://purl.uniprot.org/uniprot/Q4GYQ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/185431:Tb09.244.1740 ^@ http://purl.uniprot.org/uniprot/Q38CQ7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.6470 ^@ http://purl.uniprot.org/uniprot/Q582L2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb927.8.5960 ^@ http://purl.uniprot.org/uniprot/Q57YJ7 ^@ Similarity ^@ Belongs to the UPF0610 family. http://togogenome.org/gene/185431:Tb09.211.4500 ^@ http://purl.uniprot.org/uniprot/Q38D61 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb09.211.3760 ^@ http://purl.uniprot.org/uniprot/Q38DD3 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/185431:Tb927.5.1610 ^@ http://purl.uniprot.org/uniprot/Q585J5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/185431:Tb927.8.1960 ^@ http://purl.uniprot.org/uniprot/Q581Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb927.7.4820 ^@ http://purl.uniprot.org/uniprot/Q57X98 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/185431:Tb09.211.0790 ^@ http://purl.uniprot.org/uniprot/Q38E77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Nucleus http://togogenome.org/gene/185431:Tb927.6.1320 ^@ http://purl.uniprot.org/uniprot/Q585B1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.5.790 ^@ http://purl.uniprot.org/uniprot/Q57W24 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.8.6900 ^@ http://purl.uniprot.org/uniprot/Q57TS3 ^@ Similarity ^@ Belongs to the TRAPP small subunits family. BET3 subfamily. http://togogenome.org/gene/185431:Tb10.70.3370 ^@ http://purl.uniprot.org/uniprot/Q38BK7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).|||Cytoplasm http://togogenome.org/gene/185431:Tb10.6k15.2780 ^@ http://purl.uniprot.org/uniprot/Q38AI5 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/185431:Tb927.3.4360 ^@ http://purl.uniprot.org/uniprot/Q580K6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/185431:Tb10.70.6220 ^@ http://purl.uniprot.org/uniprot/Q38C74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/185431:Tb10.389.1210 ^@ http://purl.uniprot.org/uniprot/Q388Z4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.3.2420 ^@ http://purl.uniprot.org/uniprot/Q582V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb10.6k15.1330 ^@ http://purl.uniprot.org/uniprot/Q38A65 ^@ Function ^@ Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. http://togogenome.org/gene/185431:Tb10.70.4720 ^@ http://purl.uniprot.org/uniprot/Q38BV5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb10.61.2700 ^@ http://purl.uniprot.org/uniprot/Q388I9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/185431:Tb10.70.2610 ^@ http://purl.uniprot.org/uniprot/Q38BE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. http://togogenome.org/gene/185431:Tb927.7.7130 ^@ http://purl.uniprot.org/uniprot/Q57XT3 ^@ Similarity ^@ Belongs to the TYW1 family. http://togogenome.org/gene/185431:Tb10.6k15.2920 ^@ http://purl.uniprot.org/uniprot/Q38AJ5 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/185431:Tb09.244.2200 ^@ http://purl.uniprot.org/uniprot/Q38CT5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb10.6k15.0110 ^@ http://purl.uniprot.org/uniprot/Q389W0 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/185431:Tb927.6.1520 ^@ http://purl.uniprot.org/uniprot/Q585Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/185431:TB927.1.4140 ^@ http://purl.uniprot.org/uniprot/Q4GYG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS5 family.|||Membrane|||centriolar satellite|||cilium membrane http://togogenome.org/gene/185431:Tb927.7.4710 ^@ http://purl.uniprot.org/uniprot/Q57X87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/185431:Tb927.4.3840 ^@ http://purl.uniprot.org/uniprot/Q583H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||nucleolus http://togogenome.org/gene/185431:Tb10.61.1210 ^@ http://purl.uniprot.org/uniprot/Q4FKC0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/185431:Tb10.70.2940 ^@ http://purl.uniprot.org/uniprot/Q38BH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.4.840 ^@ http://purl.uniprot.org/uniprot/Q580B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/185431:Tb09.160.0810 ^@ http://purl.uniprot.org/uniprot/Q38FV7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.8.3800 ^@ http://purl.uniprot.org/uniprot/D6XLB5 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/185431:Tb927.4.1360 ^@ http://purl.uniprot.org/uniprot/Q581U5 ^@ Similarity ^@ Belongs to the glucose-6-phosphate 1-epimerase family. http://togogenome.org/gene/185431:Tb927.8.5380 ^@ http://purl.uniprot.org/uniprot/Q57UL0 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier. http://togogenome.org/gene/185431:Tb927.8.6580 ^@ http://purl.uniprot.org/uniprot/Q57TV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.8.1990 ^@ http://purl.uniprot.org/uniprot/D6XKT6 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/185431:Tb927.5.3930 ^@ http://purl.uniprot.org/uniprot/Q57U73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.8.2050 ^@ http://purl.uniprot.org/uniprot/Q581X7 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/185431:Tb10.70.0140 ^@ http://purl.uniprot.org/uniprot/Q38AU3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/185431:Tb10.6k15.3250 ^@ http://purl.uniprot.org/uniprot/Q38AM2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/185431:Tb09.160.2990 ^@ http://purl.uniprot.org/uniprot/Q38FA2 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/185431:Tb927.8.1490 ^@ http://purl.uniprot.org/uniprot/Q580H4 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/185431:Tb09.211.0740 ^@ http://purl.uniprot.org/uniprot/Q38E83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LSM12 family.|||Forms a complex composed of at least MKT1, PBP1, XAC1 and LSM12 (PubMed:24470144). Forms a complex composed of at least MKT1L, PBP1, XAC1 and LSM12 (PubMed:32532821). Within the complex, interacts with PBP1; the interaction is direct (PubMed:24470144, PubMed:32532821).|||Involved in post-transcriptional regulation of gene expression. http://togogenome.org/gene/185431:TB927.1.2430 ^@ http://purl.uniprot.org/uniprot/Q4GYX7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/185431:Tb927.6.3300 ^@ http://purl.uniprot.org/uniprot/D6XI63|||http://purl.uniprot.org/uniprot/Q9BPQ5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||In T.brucei, PIGM has a different substrate specificity compared to mammalian. Given that the protozoan parasite evades the immune response of mammalian hosts and digestion in the gut of the insect vector by means of its coat proteins tethered to the cell surface via GPI-anchors, it may be a good candidate for chemotherapy against African trypanosomiasis.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-PI during GPI precursor assembly (By similarity).|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.|||Membrane http://togogenome.org/gene/185431:TB927.1.2120 ^@ http://purl.uniprot.org/uniprot/Q4GZ09 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:TB927.1.2530 ^@ http://purl.uniprot.org/uniprot/Q4GYX7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/185431:Tb927.3.5530 ^@ http://purl.uniprot.org/uniprot/Q580S2 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/185431:Tb927.5.330 ^@ http://purl.uniprot.org/uniprot/Q57VY0 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.8.6810 ^@ http://purl.uniprot.org/uniprot/Q57TT2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb10.v4.0031 ^@ http://purl.uniprot.org/uniprot/Q387P0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.3350 ^@ http://purl.uniprot.org/uniprot/Q57WF0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/185431:Tb927.4.4270 ^@ http://purl.uniprot.org/uniprot/Q57Y31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.5.960 ^@ http://purl.uniprot.org/uniprot/Q57W41 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb10.100.0110 ^@ http://purl.uniprot.org/uniprot/Q38AW9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/185431:Tb927.3.3110 ^@ http://purl.uniprot.org/uniprot/Q57ZK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/185431:TB927.1.2850 ^@ http://purl.uniprot.org/uniprot/Q4GYT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.450 ^@ http://purl.uniprot.org/uniprot/Q581F3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Major surface antigen of procyclic forms.|||Membrane http://togogenome.org/gene/185431:Tb927.7.4190 ^@ http://purl.uniprot.org/uniprot/Q57UP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.8.1890 ^@ http://purl.uniprot.org/uniprot/D6XKS6 ^@ Cofactor ^@ Binds 1 heme c group covalently per subunit. http://togogenome.org/gene/185431:Tb10.70.7840 ^@ http://purl.uniprot.org/uniprot/Q38CJ1 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/185431:Tb927.3.1910 ^@ http://purl.uniprot.org/uniprot/Q57ZC0 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/185431:Tb927.2.3780 ^@ http://purl.uniprot.org/uniprot/Q586X2 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. http://togogenome.org/gene/185431:Tb10.70.5570 ^@ http://purl.uniprot.org/uniprot/Q38C26 ^@ Similarity ^@ Belongs to the RPAP2 family. http://togogenome.org/gene/185431:Tb10.61.1230 ^@ http://purl.uniprot.org/uniprot/Q387Y5 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC56 family.|||Gene knockout results in significant reduction of flagellar beating and cell swimming, and absence of outer dynein arms in the distal region of flagellum axoneme. Cell motility is characterized by an erratic swimming pattern with altered propagation of the tip-to-base wave, increased frequency of base-to-tip waves, and frequent tumbling typical of outer dynein arm mutants.|||Required for the assembly of dynein arms in the distal portion of flagellum axoneme.|||flagellum http://togogenome.org/gene/185431:Tb927.7.5310 ^@ http://purl.uniprot.org/uniprot/Q57ZF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb09.160.1570 ^@ http://purl.uniprot.org/uniprot/Q38FN2 ^@ Similarity ^@ Belongs to the EAF6 family. http://togogenome.org/gene/185431:Tb10.70.4390 ^@ http://purl.uniprot.org/uniprot/Q38BT5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. http://togogenome.org/gene/185431:Tb09.244.1570 ^@ http://purl.uniprot.org/uniprot/Q38CQ1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.2.6150 ^@ http://purl.uniprot.org/uniprot/Q586N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/185431:Tb09.160.3710 ^@ http://purl.uniprot.org/uniprot/Q38F34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/185431:Tb927.3.5180 ^@ http://purl.uniprot.org/uniprot/Q580V7 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/185431:Tb10.70.6780 ^@ http://purl.uniprot.org/uniprot/Q38CB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.70.0020 ^@ http://purl.uniprot.org/uniprot/Q38AT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/185431:Tb927.6.770 ^@ http://purl.uniprot.org/uniprot/Q583S6 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.7.5670 ^@ http://purl.uniprot.org/uniprot/Q582I2 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb927.3.960 ^@ http://purl.uniprot.org/uniprot/Q57WX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.7.4420 ^@ http://purl.uniprot.org/uniprot/Q57X58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.|||The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. http://togogenome.org/gene/185431:Tb09.244.2280 ^@ http://purl.uniprot.org/uniprot/Q38CU1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.3.3320 ^@ http://purl.uniprot.org/uniprot/Q57V54 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/185431:Tb10.70.3125 ^@ http://purl.uniprot.org/uniprot/Q38BI6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/185431:Tb10.389.1330 ^@ http://purl.uniprot.org/uniprot/Q389A3 ^@ Similarity ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. http://togogenome.org/gene/185431:Tb10.389.1170 ^@ http://purl.uniprot.org/uniprot/Q388Z2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb10.61.1810 ^@ http://purl.uniprot.org/uniprot/Q388C4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/185431:Tb927.7.1910 ^@ http://purl.uniprot.org/uniprot/Q57V19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/185431:Tb927.4.3750 ^@ http://purl.uniprot.org/uniprot/Q583G9 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.2.4720 ^@ http://purl.uniprot.org/uniprot/Q586R8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/185431:Tb927.4.3770 ^@ http://purl.uniprot.org/uniprot/Q583H1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.3.3720 ^@ http://purl.uniprot.org/uniprot/Q57WA8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.4.1320 ^@ http://purl.uniprot.org/uniprot/Q581U9 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/185431:Tb927.7.280 ^@ http://purl.uniprot.org/uniprot/Q57U26 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.3.1970 ^@ http://purl.uniprot.org/uniprot/Q57ZB4 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/185431:Tb10.6k15.2900 ^@ http://purl.uniprot.org/uniprot/Q38AJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb10.70.2570 ^@ http://purl.uniprot.org/uniprot/Q38BD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.7.6360 ^@ http://purl.uniprot.org/uniprot/Q582M3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb927.4.1850 ^@ http://purl.uniprot.org/uniprot/D6XFC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/185431:Tb10.61.3040 ^@ http://purl.uniprot.org/uniprot/Q388L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Nucleus http://togogenome.org/gene/185431:Tb10.70.1380 ^@ http://purl.uniprot.org/uniprot/Q57VP3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/185431:Tb927.3.5050 ^@ http://purl.uniprot.org/uniprot/Q582N2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/185431:Tb10.70.1200 ^@ http://purl.uniprot.org/uniprot/Q38B28 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/185431:Tb927.7.230 ^@ http://purl.uniprot.org/uniprot/Q57U30 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/185431:Tb09.160.3630 ^@ http://purl.uniprot.org/uniprot/Q38F42 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/185431:Tb927.6.430 ^@ http://purl.uniprot.org/uniprot/Q581F1 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:TB927.1.720 ^@ http://purl.uniprot.org/uniprot/Q4GZE6 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/185431:Tb09.211.3730 ^@ http://purl.uniprot.org/uniprot/Q38DD6 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. http://togogenome.org/gene/185431:Tb09.211.4470 ^@ http://purl.uniprot.org/uniprot/Q38D64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/185431:Tb927.4.1970 ^@ http://purl.uniprot.org/uniprot/Q583J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.211.4490 ^@ http://purl.uniprot.org/uniprot/Q38D64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/185431:Tb927.3.2030 ^@ http://purl.uniprot.org/uniprot/Q57ZA8 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/185431:Tb09.160.0530 ^@ http://purl.uniprot.org/uniprot/Q38FY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/185431:Tb927.6.1870 ^@ http://purl.uniprot.org/uniprot/Q585M4 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/185431:Tb09.v1.0350 ^@ http://purl.uniprot.org/uniprot/Q38EH9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/185431:Tb10.100.0180 ^@ http://purl.uniprot.org/uniprot/Q38CK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb10.70.7040 ^@ http://purl.uniprot.org/uniprot/Q38CD3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.6.4910 ^@ http://purl.uniprot.org/uniprot/Q586G3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/185431:Tb09.211.2570 ^@ http://purl.uniprot.org/uniprot/Q38DP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/185431:Tb927.5.2140 ^@ http://purl.uniprot.org/uniprot/Q582F1 ^@ Similarity ^@ Belongs to the DNA2/NAM7 helicase family. http://togogenome.org/gene/185431:Tb927.8.1610 ^@ http://purl.uniprot.org/uniprot/Q580G2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M8 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/185431:Tb10.70.1770 ^@ http://purl.uniprot.org/uniprot/Q38B73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/185431:Tb927.6.190 ^@ http://purl.uniprot.org/uniprot/Q57WZ8 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.4.3580 ^@ http://purl.uniprot.org/uniprot/Q585J0 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/185431:Tb927.6.5260 ^@ http://purl.uniprot.org/uniprot/Q583L7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.2750 ^@ http://purl.uniprot.org/uniprot/Q57Y85 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb10.70.3020 ^@ http://purl.uniprot.org/uniprot/Q38BH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/185431:Tb10.61.2070 ^@ http://purl.uniprot.org/uniprot/Q388D3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/185431:Tb10.6k15.3850 ^@ http://purl.uniprot.org/uniprot/Q38AR9 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/185431:Tb927.7.3110 ^@ http://purl.uniprot.org/uniprot/Q57YC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/185431:Tb10.26.0370 ^@ http://purl.uniprot.org/uniprot/Q389I7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS3 family. http://togogenome.org/gene/185431:Tb09.160.5670 ^@ http://purl.uniprot.org/uniprot/Q38EI1 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/185431:Tb927.7.1450 ^@ http://purl.uniprot.org/uniprot/Q57WQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/185431:Tb10.70.0110 ^@ http://purl.uniprot.org/uniprot/Q38AU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/185431:Tb09.160.2600 ^@ http://purl.uniprot.org/uniprot/Q38FD5 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/185431:Tb10.406.0440 ^@ http://purl.uniprot.org/uniprot/Q389T1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/185431:Tb10.61.2640 ^@ http://purl.uniprot.org/uniprot/Q388I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/185431:Tb927.3.3920 ^@ http://purl.uniprot.org/uniprot/Q57WC8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/185431:Tb09.211.1780 ^@ http://purl.uniprot.org/uniprot/Q38DX6 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/185431:Tb10.70.2155 ^@ http://purl.uniprot.org/uniprot/Q38B96 ^@ Similarity ^@ Belongs to the eukaryotic ATPase epsilon family. http://togogenome.org/gene/185431:Tb927.7.450 ^@ http://purl.uniprot.org/uniprot/Q57U09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.5.1260 ^@ http://purl.uniprot.org/uniprot/Q57VD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/185431:Tb927.2.4020 ^@ http://purl.uniprot.org/uniprot/Q586W2 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. http://togogenome.org/gene/185431:Tb09.211.0340 ^@ http://purl.uniprot.org/uniprot/Q38EC5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/185431:Tb10.389.1270 ^@ http://purl.uniprot.org/uniprot/Q388Z9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.6.1140 ^@ http://purl.uniprot.org/uniprot/Q585D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb927.5.1530 ^@ http://purl.uniprot.org/uniprot/Q57VB0 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/185431:Tb10.389.0280 ^@ http://purl.uniprot.org/uniprot/Q388S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||nucleolus http://togogenome.org/gene/185431:Tb927.6.1340 ^@ http://purl.uniprot.org/uniprot/Q585B3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb10.70.7750 ^@ http://purl.uniprot.org/uniprot/Q38CI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/185431:Tb09.211.3040 ^@ http://purl.uniprot.org/uniprot/Q38DK1 ^@ Similarity ^@ Belongs to the XPC family. http://togogenome.org/gene/185431:Tb927.6.4590 ^@ http://purl.uniprot.org/uniprot/Q587C5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb10.70.1740 ^@ http://purl.uniprot.org/uniprot/Q38B69 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/185431:Tb10.61.1870 ^@ http://purl.uniprot.org/uniprot/Q387N9 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/185431:Tb10.70.4155 ^@ http://purl.uniprot.org/uniprot/Q38BR9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/185431:Tb927.2.6050 ^@ http://purl.uniprot.org/uniprot/Q586P1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/185431:Tb927.4.3710 ^@ http://purl.uniprot.org/uniprot/Q585H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb927.6.4470 ^@ http://purl.uniprot.org/uniprot/Q587B3 ^@ Similarity ^@ Belongs to the eukaryotic AdoMetDC family. http://togogenome.org/gene/185431:Tb927.6.1270 ^@ http://purl.uniprot.org/uniprot/Q585C0 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/185431:Tb927.8.2090 ^@ http://purl.uniprot.org/uniprot/Q581X3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.5.4500 ^@ http://purl.uniprot.org/uniprot/Q57X54 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/185431:Tb09.211.4460 ^@ http://purl.uniprot.org/uniprot/Q38D65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/185431:Tb927.8.1340 ^@ http://purl.uniprot.org/uniprot/Q57VM1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/185431:Tb927.2.4370 ^@ http://purl.uniprot.org/uniprot/Q586P2 ^@ Similarity ^@ In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family. http://togogenome.org/gene/185431:Tb09.244.1000 ^@ http://purl.uniprot.org/uniprot/Q38CP6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.4.930 ^@ http://purl.uniprot.org/uniprot/Q580C1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/185431:TB927.1.700 ^@ http://purl.uniprot.org/uniprot/Q4GZG4 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/185431:Tb927.2.1560 ^@ http://purl.uniprot.org/uniprot/Q585R7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/185431:Tb927.4.3550 ^@ http://purl.uniprot.org/uniprot/Q585J5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/185431:Tb927.4.4680 ^@ http://purl.uniprot.org/uniprot/Q583F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS3/PSF3 family.|||Nucleus http://togogenome.org/gene/185431:Tb09.160.5590 ^@ http://purl.uniprot.org/uniprot/Q38EI9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/185431:Tb927.8.1110 ^@ http://purl.uniprot.org/uniprot/Q57VP3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/185431:Tb927.2.3480 ^@ http://purl.uniprot.org/uniprot/Q586Y0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.4.3860 ^@ http://purl.uniprot.org/uniprot/Q583I0 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.7.4390 ^@ http://purl.uniprot.org/uniprot/Q57X55 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/185431:Tb927.3.3900 ^@ http://purl.uniprot.org/uniprot/Q57WC6 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/185431:Tb09.211.1010 ^@ http://purl.uniprot.org/uniprot/Q38E55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target (By similarity).|||Membrane http://togogenome.org/gene/185431:Tb927.3.1700 ^@ http://purl.uniprot.org/uniprot/Q57ZE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/185431:Tb927.4.1250 ^@ http://purl.uniprot.org/uniprot/Q581V6 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/185431:Tb927.6.4390 ^@ http://purl.uniprot.org/uniprot/Q587A5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.3.4340 ^@ http://purl.uniprot.org/uniprot/Q580K8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. http://togogenome.org/gene/185431:Tb927.7.2510 ^@ http://purl.uniprot.org/uniprot/Q57XM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/185431:Tb927.3.1000 ^@ http://purl.uniprot.org/uniprot/Q57WY3 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/185431:Tb927.7.3180 ^@ http://purl.uniprot.org/uniprot/Q57YC8 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/185431:Tb10.05.0080 ^@ http://purl.uniprot.org/uniprot/Q388N5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/185431:Tb927.6.2680 ^@ http://purl.uniprot.org/uniprot/Q583R6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/185431:Tb09.v4.0005 ^@ http://purl.uniprot.org/uniprot/Q4FKU3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.7430 ^@ http://purl.uniprot.org/uniprot/Q57YU5 ^@ Similarity ^@ Belongs to the UQCRH/QCR6 family. http://togogenome.org/gene/185431:Tb927.6.4920 ^@ http://purl.uniprot.org/uniprot/Q586G3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/185431:Tb927.5.110 ^@ http://purl.uniprot.org/uniprot/Q57XG7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.5.470 ^@ http://purl.uniprot.org/uniprot/Q57VW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. RibJ family.|||Cell membrane|||Transporter involved in riboflavin (vitamin B2) uptake. Also transports FMN and FAD. http://togogenome.org/gene/185431:Tb927.8.2100 ^@ http://purl.uniprot.org/uniprot/D6XKU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/185431:Tb927.7.7260 ^@ http://purl.uniprot.org/uniprot/Q57XU6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.8.3150 ^@ http://purl.uniprot.org/uniprot/Q57YZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. http://togogenome.org/gene/185431:Tb927.3.5490 ^@ http://purl.uniprot.org/uniprot/Q580S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||cilium http://togogenome.org/gene/185431:Tb10.100.0090 ^@ http://purl.uniprot.org/uniprot/Q38CL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/185431:Tb10.389.0490 ^@ http://purl.uniprot.org/uniprot/Q388U5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/185431:Tb927.6.1690 ^@ http://purl.uniprot.org/uniprot/Q585P2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/185431:Tb927.7.7120 ^@ http://purl.uniprot.org/uniprot/Q57XT2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.5.2720 ^@ http://purl.uniprot.org/uniprot/Q57ZU8 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/185431:Tb10.70.7470 ^@ http://purl.uniprot.org/uniprot/Q38CG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Nucleus http://togogenome.org/gene/185431:Tb09.211.2090 ^@ http://purl.uniprot.org/uniprot/Q38DU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb927.3.190 ^@ http://purl.uniprot.org/uniprot/Q57TR8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.3470 ^@ http://purl.uniprot.org/uniprot/Q57YW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.3590 ^@ http://purl.uniprot.org/uniprot/Q38DE9 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/185431:Tb927.8.5440 ^@ http://purl.uniprot.org/uniprot/Q57UL6 ^@ Function|||Similarity ^@ Belongs to the calflagin family.|||May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form. http://togogenome.org/gene/185431:Tb927.7.7420 ^@ http://purl.uniprot.org/uniprot/Q57TX9 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/185431:Tb10.389.1260 ^@ http://purl.uniprot.org/uniprot/Q388Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/185431:Tb09.160.0570 ^@ http://purl.uniprot.org/uniprot/Q38FY2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/185431:Tb927.8.8090 ^@ http://purl.uniprot.org/uniprot/Q57WM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb927.4.1100 ^@ http://purl.uniprot.org/uniprot/Q580D8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/185431:Tb927.2.6270 ^@ http://purl.uniprot.org/uniprot/Q586M8 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/185431:Tb927.6.1880 ^@ http://purl.uniprot.org/uniprot/Q585M3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. http://togogenome.org/gene/185431:Tb10.61.3080 ^@ http://purl.uniprot.org/uniprot/Q388L5 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/185431:Tb927.4.3160 ^@ http://purl.uniprot.org/uniprot/Q583Z3 ^@ Similarity ^@ Belongs to the GPAT/DAPAT family. http://togogenome.org/gene/185431:Tb10.6k15.0990 ^@ http://purl.uniprot.org/uniprot/Q38A34 ^@ Cofactor|||Disruption Phenotype|||Function|||Similarity|||Subunit ^@ Belongs to the selenophosphate synthase 1 family. Class I subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Homodimer.|||RNAi-mediated knock down in procyclic and blood stream forms (strain 29-13) impairs growth following prolonged exposure to oxidative stress.|||Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/185431:Tb927.5.2420 ^@ http://purl.uniprot.org/uniprot/Q582C3 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/185431:Tb927.8.5020 ^@ http://purl.uniprot.org/uniprot/Q57UH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/185431:Tb927.6.4210 ^@ http://purl.uniprot.org/uniprot/Q586Y8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/185431:Tb927.2.3580 ^@ http://purl.uniprot.org/uniprot/Q586X9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/185431:Tb10.70.2920 ^@ http://purl.uniprot.org/uniprot/Q4FKP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/185431:Tb927.5.3520 ^@ http://purl.uniprot.org/uniprot/Q57UB4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit and an accessory subunit.|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/185431:Tb927.7.6130 ^@ http://purl.uniprot.org/uniprot/Q57VJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/185431:TB927.1.2570 ^@ http://purl.uniprot.org/uniprot/Q4GYW5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/185431:Tb927.6.2300 ^@ http://purl.uniprot.org/uniprot/Q584S6 ^@ Function|||Similarity ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/185431:Tb10.70.5090 ^@ http://purl.uniprot.org/uniprot/Q38BY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/185431:Tb927.6.2640 ^@ http://purl.uniprot.org/uniprot/Q583S0 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/185431:Tb10.61.0260 ^@ http://purl.uniprot.org/uniprot/Q387R3 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/185431:Tb10.v4.0025 ^@ http://purl.uniprot.org/uniprot/Q387P1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.8.7530 ^@ http://purl.uniprot.org/uniprot/Q57V74 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/185431:Tb927.3.2090 ^@ http://purl.uniprot.org/uniprot/Q57ZA2 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/185431:Tb927.3.370 ^@ http://purl.uniprot.org/uniprot/Q57TR5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.6050 ^@ http://purl.uniprot.org/uniprot/Q57VK6 ^@ Function ^@ Could act as a receptor for an unknown ligand. http://togogenome.org/gene/185431:Tb927.8.3740 ^@ http://purl.uniprot.org/uniprot/Q580Z4 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/185431:Tb10.100.0060 ^@ http://purl.uniprot.org/uniprot/Q38CM1 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/185431:Tb927.7.2550 ^@ http://purl.uniprot.org/uniprot/Q57XL9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/185431:Tb927.3.1280 ^@ http://purl.uniprot.org/uniprot/Q57XW1 ^@ Similarity ^@ Belongs to the NPL4 family. http://togogenome.org/gene/185431:Tb09.160.5650 ^@ http://purl.uniprot.org/uniprot/Q38EI3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/185431:TB927.1.3950 ^@ http://purl.uniprot.org/uniprot/Q4GYI2 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/185431:Tb09.211.3160 ^@ http://purl.uniprot.org/uniprot/Q38DI9 ^@ Similarity ^@ Belongs to the THADA family. http://togogenome.org/gene/185431:Tb927.2.5850 ^@ http://purl.uniprot.org/uniprot/Q586C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/185431:Tb927.6.4480 ^@ http://purl.uniprot.org/uniprot/Q587B4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb10.70.6470 ^@ http://purl.uniprot.org/uniprot/Q38C91 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/185431:Tb927.3.2510 ^@ http://purl.uniprot.org/uniprot/Q582W4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb927.7.300 ^@ http://purl.uniprot.org/uniprot/Q57U24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/185431:Tb10.70.2190 ^@ http://purl.uniprot.org/uniprot/Q38BA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Mitochondrion http://togogenome.org/gene/185431:Tb09.160.3380 ^@ http://purl.uniprot.org/uniprot/Q38F65 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/185431:Tb10.389.0130 ^@ http://purl.uniprot.org/uniprot/Q388R7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/185431:Tb927.3.3160 ^@ http://purl.uniprot.org/uniprot/Q57ZJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Nucleus http://togogenome.org/gene/185431:TB927.1.2510 ^@ http://purl.uniprot.org/uniprot/Q4GYX7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/185431:Tb927.7.4790 ^@ http://purl.uniprot.org/uniprot/Q57X95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/185431:Tb10.6k15.2510 ^@ http://purl.uniprot.org/uniprot/Q38AG1 ^@ Similarity ^@ Belongs to the ATPase delta chain family. http://togogenome.org/gene/185431:Tb09.160.4430 ^@ http://purl.uniprot.org/uniprot/Q38EW4 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily. http://togogenome.org/gene/185431:Tb927.8.170 ^@ http://purl.uniprot.org/uniprot/Q57XI7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes. http://togogenome.org/gene/185431:Tb09.211.0430 ^@ http://purl.uniprot.org/uniprot/Q38EB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/185431:Tb09.211.3210 ^@ http://purl.uniprot.org/uniprot/Q38DI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum http://togogenome.org/gene/185431:Tb927.3.2020 ^@ http://purl.uniprot.org/uniprot/Q57ZA9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/185431:Tb927.6.5050 ^@ http://purl.uniprot.org/uniprot/Q586H7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/185431:Tb927.4.830 ^@ http://purl.uniprot.org/uniprot/Q580B1 ^@ Similarity ^@ Belongs to the PET191 family. http://togogenome.org/gene/185431:Tb10.6k15.1380 ^@ http://purl.uniprot.org/uniprot/Q38A69 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/185431:Tb09.211.3810 ^@ http://purl.uniprot.org/uniprot/Q38DC8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/185431:Tb09.160.1240 ^@ http://purl.uniprot.org/uniprot/Q38FR2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. http://togogenome.org/gene/185431:Tb09.160.5600 ^@ http://purl.uniprot.org/uniprot/Q38EI8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/185431:Tb10.6k15.0510 ^@ http://purl.uniprot.org/uniprot/Q389Z6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/185431:Tb10.70.3510 ^@ http://purl.uniprot.org/uniprot/Q382C4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/185431:Tb09.211.2190 ^@ http://purl.uniprot.org/uniprot/Q38DT8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/185431:Tb927.8.6680 ^@ http://purl.uniprot.org/uniprot/Q57TU5 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/185431:Tb927.5.4810 ^@ http://purl.uniprot.org/uniprot/Q57X37 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.