http://togogenome.org/gene/37040:LHFPL2 ^@ http://purl.uniprot.org/uniprot/A0A093F1H1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:TMEM184B ^@ http://purl.uniprot.org/uniprot/A0A093FIH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:CPB1 ^@ http://purl.uniprot.org/uniprot/A0A093FC13 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/37040:NRXN3 ^@ http://purl.uniprot.org/uniprot/A0A093EUJ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A093F381 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/37040:RAD52 ^@ http://purl.uniprot.org/uniprot/A0A093FIV1 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/37040:LEAP2 ^@ http://purl.uniprot.org/uniprot/A0A093FRT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LEAP2 family.|||Has an antimicrobial activity.|||Secreted http://togogenome.org/gene/37040:MAFK ^@ http://purl.uniprot.org/uniprot/A0A093ENL0 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/37040:AP1S2 ^@ http://purl.uniprot.org/uniprot/A0A093F0C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/37040:KCNH7 ^@ http://purl.uniprot.org/uniprot/A0A093EW71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:TMEM255B ^@ http://purl.uniprot.org/uniprot/A0A093F9G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/37040:ASRGL1 ^@ http://purl.uniprot.org/uniprot/A0A093F726 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/37040:RBM22 ^@ http://purl.uniprot.org/uniprot/A0A093FLR1 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/37040:RGS9BP ^@ http://purl.uniprot.org/uniprot/A0A093HZR0 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/37040:DMGDH ^@ http://purl.uniprot.org/uniprot/A0A093F5H1 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/37040:GJA3 ^@ http://purl.uniprot.org/uniprot/A0A093HXN2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/37040:B3GNT2 ^@ http://purl.uniprot.org/uniprot/A0A093FS67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/37040:TMEM121 ^@ http://purl.uniprot.org/uniprot/A0A093FF72 ^@ Similarity ^@ Belongs to the TMEM121 family. http://togogenome.org/gene/37040:FGFBP2 ^@ http://purl.uniprot.org/uniprot/A0A093F231 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/37040:POMK ^@ http://purl.uniprot.org/uniprot/A0A093HD53 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/37040:PLRG1 ^@ http://purl.uniprot.org/uniprot/A0A093EZ13 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/37040:NIPAL3 ^@ http://purl.uniprot.org/uniprot/A0A093FJP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/37040:BCR ^@ http://purl.uniprot.org/uniprot/A0A093F6H9 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/37040:SRP54 ^@ http://purl.uniprot.org/uniprot/A0A093F4L6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/37040:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A093ETH3 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/37040:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/A0A093F6J8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/37040:PRKAB2 ^@ http://purl.uniprot.org/uniprot/A0A093EQP0 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/37040:ARPC2 ^@ http://purl.uniprot.org/uniprot/A0A093HID6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/37040:CRYAB ^@ http://purl.uniprot.org/uniprot/A0A093F4P3 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/37040:PAQR8 ^@ http://purl.uniprot.org/uniprot/A0A093HCC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/37040:SLC39A3 ^@ http://purl.uniprot.org/uniprot/A0A093FE36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A093H1I9 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/37040:SLC7A1 ^@ http://purl.uniprot.org/uniprot/A0A093FC54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:BMP5 ^@ http://purl.uniprot.org/uniprot/A0A093F6Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/37040:TMEM177 ^@ http://purl.uniprot.org/uniprot/A0A093F3D3 ^@ Function|||Similarity ^@ Belongs to the TMEM177 family.|||Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. http://togogenome.org/gene/37040:MYBL1 ^@ http://purl.uniprot.org/uniprot/A0A093F5C7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:MDM4 ^@ http://purl.uniprot.org/uniprot/A0A093EYH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/37040:DRD1 ^@ http://purl.uniprot.org/uniprot/A0A093FL90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:NUP50 ^@ http://purl.uniprot.org/uniprot/A0A093F667 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/37040:LOC104257729 ^@ http://purl.uniprot.org/uniprot/A0A093GXL1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/37040:LOC104260587 ^@ http://purl.uniprot.org/uniprot/A0A093HRP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/37040:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/A0A093FP68 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/37040:CLRN3 ^@ http://purl.uniprot.org/uniprot/A0A093HF95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/37040:MET ^@ http://purl.uniprot.org/uniprot/A0A093FVZ7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/37040:SLC6A1 ^@ http://purl.uniprot.org/uniprot/A0A093EYH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/37040:NDUFB4 ^@ http://purl.uniprot.org/uniprot/A0A093FAI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/37040:CELF1 ^@ http://purl.uniprot.org/uniprot/A0A093FMV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/37040:LRRC8D ^@ http://purl.uniprot.org/uniprot/A0A093FBP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:CPLX4 ^@ http://purl.uniprot.org/uniprot/A0A093FTM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/37040:PALS1 ^@ http://purl.uniprot.org/uniprot/A0A093FHL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||tight junction http://togogenome.org/gene/37040:GJA1 ^@ http://purl.uniprot.org/uniprot/A0A093HH33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/37040:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A093FJ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/37040:SLC5A7 ^@ http://purl.uniprot.org/uniprot/A0A093EZC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/37040:GTF2H2 ^@ http://purl.uniprot.org/uniprot/A0A093EZP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/37040:CRYAA ^@ http://purl.uniprot.org/uniprot/A0A093HTQ0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/37040:MACIR ^@ http://purl.uniprot.org/uniprot/A0A093F012 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/37040:AP3S1 ^@ http://purl.uniprot.org/uniprot/A0A093F7I3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/37040:NDUFS1 ^@ http://purl.uniprot.org/uniprot/A0A093HIM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 75 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/37040:GDAP2 ^@ http://purl.uniprot.org/uniprot/A0A093F523 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/37040:MNAT1 ^@ http://purl.uniprot.org/uniprot/A0A093FYD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:EIF2S1 ^@ http://purl.uniprot.org/uniprot/A0A093GYJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/37040:EMC2 ^@ http://purl.uniprot.org/uniprot/A0A093HWU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/37040:PLPPR5 ^@ http://purl.uniprot.org/uniprot/A0A093EX59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/37040:LOC104261530 ^@ http://purl.uniprot.org/uniprot/A0A093FVF2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/37040:YES1 ^@ http://purl.uniprot.org/uniprot/A0A093FM03 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/37040:BET1 ^@ http://purl.uniprot.org/uniprot/A0A093FNQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:VPS26C ^@ http://purl.uniprot.org/uniprot/A0A093FY92 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/37040:PTX3 ^@ http://purl.uniprot.org/uniprot/A0A093FI79 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A093EWM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/37040:UBLCP1 ^@ http://purl.uniprot.org/uniprot/A0A093F1J0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:PPP2R5E ^@ http://purl.uniprot.org/uniprot/A0A093F7J6 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/37040:LOC104254225 ^@ http://purl.uniprot.org/uniprot/A0A093EYR2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/37040:LOC104261611 ^@ http://purl.uniprot.org/uniprot/A0A093HV46 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/37040:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A093G247 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/37040:ATP10B ^@ http://purl.uniprot.org/uniprot/A0A093FVM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/37040:C8B ^@ http://purl.uniprot.org/uniprot/A0A093ETW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/37040:GEM ^@ http://purl.uniprot.org/uniprot/A0A093EXA8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/37040:RBM48 ^@ http://purl.uniprot.org/uniprot/A0A093H9U8 ^@ Function|||Similarity ^@ As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.|||Belongs to the RBM48 family. http://togogenome.org/gene/37040:SCG2 ^@ http://purl.uniprot.org/uniprot/A0A093EQU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/37040:FGF6 ^@ http://purl.uniprot.org/uniprot/A0A093FF50 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/37040:ODAD4 ^@ http://purl.uniprot.org/uniprot/A0A093FEH2 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/37040:DMBX1 ^@ http://purl.uniprot.org/uniprot/A0A093I1K8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:BDNF ^@ http://purl.uniprot.org/uniprot/A0A093F676 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.|||Secreted http://togogenome.org/gene/37040:SEC23A ^@ http://purl.uniprot.org/uniprot/A0A093ETA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/37040:HTR1E ^@ http://purl.uniprot.org/uniprot/A0A093FCY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:CLDN14 ^@ http://purl.uniprot.org/uniprot/A0A093GXW2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/37040:ISCA1 ^@ http://purl.uniprot.org/uniprot/A0A093FCV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/37040:BDH1 ^@ http://purl.uniprot.org/uniprot/A0A093GYT5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/37040:PLIN2 ^@ http://purl.uniprot.org/uniprot/A0A093FH14 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/37040:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A093FUI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/37040:GINS1 ^@ http://purl.uniprot.org/uniprot/A0A093EZJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. http://togogenome.org/gene/37040:RPL6 ^@ http://purl.uniprot.org/uniprot/A0A093FNX9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/37040:LOC104260632 ^@ http://purl.uniprot.org/uniprot/A0A093FSH3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/37040:PTER ^@ http://purl.uniprot.org/uniprot/A0A093F1P3 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:HACL1 ^@ http://purl.uniprot.org/uniprot/A0A093HFE7 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/37040:LOC104253435 ^@ http://purl.uniprot.org/uniprot/A0A093F5Z2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/37040:NR3C1 ^@ http://purl.uniprot.org/uniprot/A0A093ETX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/37040:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A093FJC3 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/37040:SNRPD3 ^@ http://purl.uniprot.org/uniprot/A0A093FV91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/37040:DHDDS ^@ http://purl.uniprot.org/uniprot/A0A093FCX7 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/37040:CRHBP ^@ http://purl.uniprot.org/uniprot/A0A093FEP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/37040:FRRS1 ^@ http://purl.uniprot.org/uniprot/A0A093HD65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRRS1 family.|||Membrane http://togogenome.org/gene/37040:LOC104258534 ^@ http://purl.uniprot.org/uniprot/A0A093HJI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/37040:WASF3 ^@ http://purl.uniprot.org/uniprot/A0A093G2C4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/37040:GOLT1A ^@ http://purl.uniprot.org/uniprot/A0A093EV20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/37040:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/A0A093HJG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/37040:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A093ENR8 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/37040:SYT1 ^@ http://purl.uniprot.org/uniprot/A0A093FGJ4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/37040:S100B ^@ http://purl.uniprot.org/uniprot/A0A093HSU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/37040:HMGB2 ^@ http://purl.uniprot.org/uniprot/A0A093F7K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/37040:NSG1 ^@ http://purl.uniprot.org/uniprot/A0A093FPS4 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/37040:GDF9 ^@ http://purl.uniprot.org/uniprot/A0A093FC80 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/37040:LOC104259124 ^@ http://purl.uniprot.org/uniprot/A0A093FM66 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/37040:SPECC1L ^@ http://purl.uniprot.org/uniprot/A0A093FKK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/37040:UNG ^@ http://purl.uniprot.org/uniprot/A0A093F9J9 ^@ Function|||Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/37040:PLPPR4 ^@ http://purl.uniprot.org/uniprot/A0A093FLH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/37040:HTR2A ^@ http://purl.uniprot.org/uniprot/A0A093HFP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/37040:CENPV ^@ http://purl.uniprot.org/uniprot/A0A093FHW7 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/37040:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A093F7H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/37040:PHKG1 ^@ http://purl.uniprot.org/uniprot/A0A093H9M0 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/37040:ANO10 ^@ http://purl.uniprot.org/uniprot/A0A093FWU0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/37040:FKTN ^@ http://purl.uniprot.org/uniprot/A0A093FEM5 ^@ Similarity ^@ Belongs to the LicD transferase family. http://togogenome.org/gene/37040:RMI1 ^@ http://purl.uniprot.org/uniprot/A0A093H4L1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/37040:EGF ^@ http://purl.uniprot.org/uniprot/A0A093H981 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:LOC104264535 ^@ http://purl.uniprot.org/uniprot/A0A093F3T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:ELAVL1 ^@ http://purl.uniprot.org/uniprot/A0A093FP30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm http://togogenome.org/gene/37040:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A093ETA7 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/37040:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/A0A093FD36 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/37040:MYMK ^@ http://purl.uniprot.org/uniprot/A0A093EV36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:VPS36 ^@ http://purl.uniprot.org/uniprot/A0A093F0I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/37040:INHBA ^@ http://purl.uniprot.org/uniprot/A0A093HZE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/37040:LOC104258364 ^@ http://purl.uniprot.org/uniprot/A0A093FD51 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/37040:RNF20 ^@ http://purl.uniprot.org/uniprot/A0A093HCL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE1 family.|||Nucleus http://togogenome.org/gene/37040:TRPC5 ^@ http://purl.uniprot.org/uniprot/A0A093EXM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:TCEANC ^@ http://purl.uniprot.org/uniprot/A0A093FRB6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:RFLNA ^@ http://purl.uniprot.org/uniprot/A0A093F996 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/37040:GPR12 ^@ http://purl.uniprot.org/uniprot/A0A093F1M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:HSPD1 ^@ http://purl.uniprot.org/uniprot/A0A093HVQ0 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/37040:POLR3H ^@ http://purl.uniprot.org/uniprot/A0A093FEV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/37040:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A093F7Z1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/37040:PLCB4 ^@ http://purl.uniprot.org/uniprot/A0A093F6Z1 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/37040:ANXA7 ^@ http://purl.uniprot.org/uniprot/A0A093F9D3 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/37040:MINAR1 ^@ http://purl.uniprot.org/uniprot/A0A093HHV1 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/37040:ABCA5 ^@ http://purl.uniprot.org/uniprot/A0A093H4J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/A0A093FP45 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/37040:HMGB3 ^@ http://purl.uniprot.org/uniprot/A0A093ESA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/37040:PTP4A1 ^@ http://purl.uniprot.org/uniprot/A0A093FSL3 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/37040:SLC5A11 ^@ http://purl.uniprot.org/uniprot/A0A093HFR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/37040:PLN ^@ http://purl.uniprot.org/uniprot/A0A093FRA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/37040:DNTT ^@ http://purl.uniprot.org/uniprot/A0A093EPJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. http://togogenome.org/gene/37040:TSSC4 ^@ http://purl.uniprot.org/uniprot/A0A093FKQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/37040:LOC104257472 ^@ http://purl.uniprot.org/uniprot/A0A093GXF7 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/37040:C15H19orf12 ^@ http://purl.uniprot.org/uniprot/A0A093F9C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/37040:SLC16A9 ^@ http://purl.uniprot.org/uniprot/A0A093FH17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:PCYT1A ^@ http://purl.uniprot.org/uniprot/A0A093FHK3 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/37040:CLTRN ^@ http://purl.uniprot.org/uniprot/A0A093HVG6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/37040:LOC104254245 ^@ http://purl.uniprot.org/uniprot/A0A093F8I2 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/37040:TSPAN18 ^@ http://purl.uniprot.org/uniprot/A0A093EWW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/37040:FAM20B ^@ http://purl.uniprot.org/uniprot/A0A093FSE5 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/37040:RPL36 ^@ http://purl.uniprot.org/uniprot/A0A093HZB1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/37040:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A093HDJ0 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/37040:LOC104264553 ^@ http://purl.uniprot.org/uniprot/A0A093EXA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/37040:SIN3A ^@ http://purl.uniprot.org/uniprot/A0A093FHE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:LOC104261894 ^@ http://purl.uniprot.org/uniprot/A0A093FWP4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/37040:TPT1 ^@ http://purl.uniprot.org/uniprot/A0A093HAH2 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/37040:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A093FQA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/37040:SPDL1 ^@ http://purl.uniprot.org/uniprot/A0A093FP28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Spindly family.|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.|||kinetochore http://togogenome.org/gene/37040:CALHM1 ^@ http://purl.uniprot.org/uniprot/A0A093F6N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/37040:LOC104254783 ^@ http://purl.uniprot.org/uniprot/A0A093H919 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/37040:PCBD2 ^@ http://purl.uniprot.org/uniprot/A0A093FUX9 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/37040:DPT ^@ http://purl.uniprot.org/uniprot/A0A093G0T4 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/37040:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A093GZY1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/37040:LOC104261609 ^@ http://purl.uniprot.org/uniprot/A0A093FKZ2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/37040:ABCC5 ^@ http://purl.uniprot.org/uniprot/A0A093F623 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:ANKRD34B ^@ http://purl.uniprot.org/uniprot/A0A093FR86 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/37040:DDC ^@ http://purl.uniprot.org/uniprot/A0A093G0D5 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/37040:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A093FJL5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/37040:HIBCH ^@ http://purl.uniprot.org/uniprot/A0A093FAQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/37040:TADA2A ^@ http://purl.uniprot.org/uniprot/A0A093FL75 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:MAPK6 ^@ http://purl.uniprot.org/uniprot/A0A093G0Y8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/37040:SH3BP4 ^@ http://purl.uniprot.org/uniprot/A0A093FD45 ^@ Subcellular Location Annotation ^@ Nucleus|||Vesicle|||clathrin-coated pit|||clathrin-coated vesicle http://togogenome.org/gene/37040:SGMS2 ^@ http://purl.uniprot.org/uniprot/A0A093F3S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/37040:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/A0A093HMC1 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/37040:ANXA1 ^@ http://purl.uniprot.org/uniprot/A0A093FXX8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasm|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium http://togogenome.org/gene/37040:GRIN3A ^@ http://purl.uniprot.org/uniprot/A0A093FLR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/37040:LOC104264009 ^@ http://purl.uniprot.org/uniprot/A0A093H0I5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/37040:SCAMP1 ^@ http://purl.uniprot.org/uniprot/A0A093FDN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/37040:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A093F675 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/37040:ASF1A ^@ http://purl.uniprot.org/uniprot/A0A093FDB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/37040:STAMBP ^@ http://purl.uniprot.org/uniprot/A0A093FQX5 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/37040:BIRC2 ^@ http://purl.uniprot.org/uniprot/A0A093FR26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/37040:HYCC2 ^@ http://purl.uniprot.org/uniprot/A0A093H0T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/37040:TNMD ^@ http://purl.uniprot.org/uniprot/A0A093HX85 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/37040:MSH2 ^@ http://purl.uniprot.org/uniprot/A0A093FMG3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/37040:WASHC1 ^@ http://purl.uniprot.org/uniprot/A0A093HHA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WASH1 family.|||Early endosome membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/37040:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A093EZ74 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/37040:LIG4 ^@ http://purl.uniprot.org/uniprot/A0A093F062 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/37040:MMP23B ^@ http://purl.uniprot.org/uniprot/A0A093F562 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:PDE6B ^@ http://purl.uniprot.org/uniprot/A0A093FPJ7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/37040:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/A0A093F0T9 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/37040:BUD23 ^@ http://purl.uniprot.org/uniprot/A0A093H7G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/37040:SLCO3A1 ^@ http://purl.uniprot.org/uniprot/A0A093F0D4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/37040:MAT1A ^@ http://purl.uniprot.org/uniprot/A0A093ETD7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/37040:SPSB1 ^@ http://purl.uniprot.org/uniprot/A0A093EWL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/37040:ARK2N ^@ http://purl.uniprot.org/uniprot/A0A093HF85 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:CSTF1 ^@ http://purl.uniprot.org/uniprot/A0A093FXT7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:PTH ^@ http://purl.uniprot.org/uniprot/A0A093GYA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.|||Secreted http://togogenome.org/gene/37040:HOPX ^@ http://purl.uniprot.org/uniprot/A0A093FNF3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:CEBPG ^@ http://purl.uniprot.org/uniprot/A0A093FZH8 ^@ Similarity ^@ Belongs to the bZIP family. C/EBP subfamily. http://togogenome.org/gene/37040:LOC104263787 ^@ http://purl.uniprot.org/uniprot/A0A093ERJ9 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/37040:A1CF ^@ http://purl.uniprot.org/uniprot/A0A093FK65 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/37040:PRPF4B ^@ http://purl.uniprot.org/uniprot/A0A093F1J3 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/37040:NSG2 ^@ http://purl.uniprot.org/uniprot/A0A093FYS7 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/37040:MIS12 ^@ http://purl.uniprot.org/uniprot/A0A093FG53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mis12 family.|||kinetochore http://togogenome.org/gene/37040:MAP2 ^@ http://purl.uniprot.org/uniprot/A0A093EXG7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/37040:ACO2 ^@ http://purl.uniprot.org/uniprot/A0A093HDP5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/37040:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A093FJY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/37040:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A093FUH2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||cytoskeleton http://togogenome.org/gene/37040:CSNK2A2 ^@ http://purl.uniprot.org/uniprot/A0A093FJ79 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/37040:LRRC8C ^@ http://purl.uniprot.org/uniprot/A0A093FEB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:DPY19L3 ^@ http://purl.uniprot.org/uniprot/A0A093FDZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/37040:MTURN ^@ http://purl.uniprot.org/uniprot/A0A093FBL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTURN family.|||Cytoplasm http://togogenome.org/gene/37040:ZNF706 ^@ http://purl.uniprot.org/uniprot/A0A093FZ20 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/37040:LPGAT1 ^@ http://purl.uniprot.org/uniprot/A0A093FTP8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/37040:OGN ^@ http://purl.uniprot.org/uniprot/A0A093FUX0 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/37040:NCK2 ^@ http://purl.uniprot.org/uniprot/A0A093F8M0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/37040:RUVBL1 ^@ http://purl.uniprot.org/uniprot/A0A093F0A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/37040:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A093FLX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/37040:EEIG1 ^@ http://purl.uniprot.org/uniprot/A0A093FEQ5 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/37040:LPAR3 ^@ http://purl.uniprot.org/uniprot/A0A093F684 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:SLC16A3 ^@ http://purl.uniprot.org/uniprot/A0A093F4W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/37040:LOC104264191 ^@ http://purl.uniprot.org/uniprot/A0A093ESW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/37040:TNFSF13B ^@ http://purl.uniprot.org/uniprot/A0A093ERC9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/37040:POLR2J ^@ http://purl.uniprot.org/uniprot/A0A093FIR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/37040:RAB9B ^@ http://purl.uniprot.org/uniprot/A0A093H7C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/37040:IMMP1L ^@ http://purl.uniprot.org/uniprot/A0A093F5Q8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/37040:BCL2A1 ^@ http://purl.uniprot.org/uniprot/A0A093FNK1 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/37040:HAUS3 ^@ http://purl.uniprot.org/uniprot/A0A093FQQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/37040:SEC22C ^@ http://purl.uniprot.org/uniprot/A0A093FC06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/37040:LOC104254174 ^@ http://purl.uniprot.org/uniprot/A0A093H6W5 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/37040:SDC3 ^@ http://purl.uniprot.org/uniprot/A0A093ERV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/37040:PRKCD ^@ http://purl.uniprot.org/uniprot/A0A093HWB7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.|||Cytoplasm|||Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||perinuclear region http://togogenome.org/gene/37040:EFEMP1 ^@ http://purl.uniprot.org/uniprot/A0A093H9A6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:LPAR4 ^@ http://purl.uniprot.org/uniprot/A0A093FLZ1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/37040:ACSL4 ^@ http://purl.uniprot.org/uniprot/A0A093FIG5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/37040:PCK1 ^@ http://purl.uniprot.org/uniprot/A0A093FFG0 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/37040:DHCR7 ^@ http://purl.uniprot.org/uniprot/A0A093FK09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/37040:NDP ^@ http://purl.uniprot.org/uniprot/A0A093GY31 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/37040:CNOT8 ^@ http://purl.uniprot.org/uniprot/A0A093FBR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/37040:ABRAXAS2 ^@ http://purl.uniprot.org/uniprot/A0A093FDI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abro1 subfamily.|||Nucleus|||spindle pole http://togogenome.org/gene/37040:ELP4 ^@ http://purl.uniprot.org/uniprot/A0A093F3W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/37040:EOGT ^@ http://purl.uniprot.org/uniprot/A0A093HPG1 ^@ Similarity ^@ Belongs to the glycosyltransferase 61 family. http://togogenome.org/gene/37040:HS3ST5 ^@ http://purl.uniprot.org/uniprot/A0A093FCD6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/37040:TSPAN14 ^@ http://purl.uniprot.org/uniprot/A0A093FM10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/37040:SEMA5B ^@ http://purl.uniprot.org/uniprot/A0A093H2S5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:RPS11 ^@ http://purl.uniprot.org/uniprot/A0A093FQS6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/37040:LOC104264625 ^@ http://purl.uniprot.org/uniprot/A0A093F3Y6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/37040:SENP8 ^@ http://purl.uniprot.org/uniprot/A0A093EYQ8 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/37040:SLC5A3 ^@ http://purl.uniprot.org/uniprot/A0A093FVW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/37040:PRDM1 ^@ http://purl.uniprot.org/uniprot/A0A093EXU3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A093F3S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/37040:CKMT2 ^@ http://purl.uniprot.org/uniprot/A0A093HJC6 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/37040:TMEM229B ^@ http://purl.uniprot.org/uniprot/A0A093FDU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/37040:EMP2 ^@ http://purl.uniprot.org/uniprot/A0A093FHI8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/37040:FHIP2A ^@ http://purl.uniprot.org/uniprot/A0A093FR24 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/37040:BAZ1B ^@ http://purl.uniprot.org/uniprot/A0A093H2N9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:DNAL4 ^@ http://purl.uniprot.org/uniprot/A0A093EUK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/37040:GTF2E2 ^@ http://purl.uniprot.org/uniprot/A0A093EUV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/37040:ASPH ^@ http://purl.uniprot.org/uniprot/A0A093F5K3 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/37040:HDX ^@ http://purl.uniprot.org/uniprot/A0A093EZY2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:MPPED1 ^@ http://purl.uniprot.org/uniprot/A0A093HWF3 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/37040:RFLNB ^@ http://purl.uniprot.org/uniprot/A0A093FJQ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/37040:INTS13 ^@ http://purl.uniprot.org/uniprot/A0A093HXP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/37040:GPX7 ^@ http://purl.uniprot.org/uniprot/A0A093H1B2 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/37040:MAFG ^@ http://purl.uniprot.org/uniprot/A0A093F6S1 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/37040:CEP55 ^@ http://purl.uniprot.org/uniprot/A0A093FDV9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/37040:RNF182 ^@ http://purl.uniprot.org/uniprot/A0A093F658 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/37040:GTF2H1 ^@ http://purl.uniprot.org/uniprot/A0A093F943 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/37040:RCAN3 ^@ http://purl.uniprot.org/uniprot/A0A093FAU8 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/37040:LOC104257574 ^@ http://purl.uniprot.org/uniprot/A0A093FB86 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/37040:MAPK9 ^@ http://purl.uniprot.org/uniprot/A0A093F6Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/37040:ZC3H15 ^@ http://purl.uniprot.org/uniprot/A0A093FAJ6 ^@ Similarity ^@ Belongs to the ZC3H15/TMA46 family. http://togogenome.org/gene/37040:LOC104261650 ^@ http://purl.uniprot.org/uniprot/A0A093FL52 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/37040:PCSK1 ^@ http://purl.uniprot.org/uniprot/A0A093ER99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/37040:LOC104262964 ^@ http://purl.uniprot.org/uniprot/A0A093FQH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/37040:TMEM86A ^@ http://purl.uniprot.org/uniprot/A0A093EZ11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/37040:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/A0A093FLU6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/37040:B3GALT2 ^@ http://purl.uniprot.org/uniprot/A0A093FM42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/37040:ADA2 ^@ http://purl.uniprot.org/uniprot/A0A093FDR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/37040:CALCA ^@ http://purl.uniprot.org/uniprot/A0A093EZ52 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/37040:FAM53A ^@ http://purl.uniprot.org/uniprot/A0A093HPC3 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/37040:LOC104261805 ^@ http://purl.uniprot.org/uniprot/A0A093FWC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/37040:CCK ^@ http://purl.uniprot.org/uniprot/A0A093FJJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/37040:GPLD1 ^@ http://purl.uniprot.org/uniprot/A0A093EYC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/37040:LOC104257580 ^@ http://purl.uniprot.org/uniprot/A0A093FB95 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/37040:MMP2 ^@ http://purl.uniprot.org/uniprot/A0A093H6M0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/37040:TMEM35A ^@ http://purl.uniprot.org/uniprot/A0A093H307 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/37040:INS ^@ http://purl.uniprot.org/uniprot/A0A093F406 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/37040:TRMT11 ^@ http://purl.uniprot.org/uniprot/A0A093HGR2 ^@ Function ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. http://togogenome.org/gene/37040:EPB41 ^@ http://purl.uniprot.org/uniprot/A0A093FK10 ^@ Subcellular Location Annotation ^@ Nucleus|||cell cortex|||cytoskeleton http://togogenome.org/gene/37040:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/A0A093FNE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/37040:NFRKB ^@ http://purl.uniprot.org/uniprot/A0A093FBV6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:NUDT12 ^@ http://purl.uniprot.org/uniprot/A0A093EX92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/37040:CAPZA1 ^@ http://purl.uniprot.org/uniprot/A0A093FLD3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/37040:PLXNB2 ^@ http://purl.uniprot.org/uniprot/A0A093FPV2 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:MFSD11 ^@ http://purl.uniprot.org/uniprot/A0A093FHW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/37040:LRP8 ^@ http://purl.uniprot.org/uniprot/A0A093FBC6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:BROX ^@ http://purl.uniprot.org/uniprot/A0A093EXM7 ^@ Similarity ^@ Belongs to the BROX family. http://togogenome.org/gene/37040:DERL2 ^@ http://purl.uniprot.org/uniprot/A0A093F753 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/37040:EPYC ^@ http://purl.uniprot.org/uniprot/A0A093FC36 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/37040:PRKAB1 ^@ http://purl.uniprot.org/uniprot/A0A093EUE0 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/37040:LOC104259212 ^@ http://purl.uniprot.org/uniprot/A0A093FCU2 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/37040:LOC104264157 ^@ http://purl.uniprot.org/uniprot/A0A093EW13 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/37040:MSTN ^@ http://purl.uniprot.org/uniprot/A0A093FDT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/37040:RPL3 ^@ http://purl.uniprot.org/uniprot/A0A093FF37 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/37040:TENT5C ^@ http://purl.uniprot.org/uniprot/A0A093EY09 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/37040:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A093FKI7 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/37040:PTPN4 ^@ http://purl.uniprot.org/uniprot/A0A093FEA1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. http://togogenome.org/gene/37040:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A093FE56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/37040:MSH4 ^@ http://purl.uniprot.org/uniprot/A0A093FBJ4 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/37040:MRPL23 ^@ http://purl.uniprot.org/uniprot/A0A093F1C1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/37040:CTLA4 ^@ http://purl.uniprot.org/uniprot/A0A093FW35 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/37040:ODC1 ^@ http://purl.uniprot.org/uniprot/A0A093FCU3 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/37040:ALB ^@ http://purl.uniprot.org/uniprot/A0A093FHI9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/37040:UBN1 ^@ http://purl.uniprot.org/uniprot/A0A093GYQ7 ^@ Similarity ^@ Belongs to the ubinuclein family. http://togogenome.org/gene/37040:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/A0A093FKG6 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/37040:LOC104258919 ^@ http://purl.uniprot.org/uniprot/A0A093FLK1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/37040:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A093F260 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/37040:LOC104263084 ^@ http://purl.uniprot.org/uniprot/A0A093FQY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||cytoskeleton http://togogenome.org/gene/37040:YPEL5 ^@ http://purl.uniprot.org/uniprot/A0A093F1T4 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/37040:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A093EUP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/37040:NIM1K ^@ http://purl.uniprot.org/uniprot/A0A093FBU8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/37040:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/A0A093HTJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/37040:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A093F111 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/37040:TOLLIP ^@ http://purl.uniprot.org/uniprot/A0A093FGE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tollip family.|||Cytoplasm http://togogenome.org/gene/37040:CLDN20 ^@ http://purl.uniprot.org/uniprot/A0A093F1N9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/37040:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A093FAE0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:ASPA ^@ http://purl.uniprot.org/uniprot/A0A093FXY7 ^@ Cofactor|||Similarity ^@ Belongs to the AspA/AstE family. Aspartoacylase subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/37040:CCDC153 ^@ http://purl.uniprot.org/uniprot/A0A093FNC6 ^@ Similarity ^@ Belongs to the UPF0610 family. http://togogenome.org/gene/37040:ACER3 ^@ http://purl.uniprot.org/uniprot/A0A093FEX3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/37040:NR1H3 ^@ http://purl.uniprot.org/uniprot/A0A093FZ05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/37040:CSTPP1 ^@ http://purl.uniprot.org/uniprot/A0A093HXF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/37040:UBE2H ^@ http://purl.uniprot.org/uniprot/A0A093HDW1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/37040:PSMB7 ^@ http://purl.uniprot.org/uniprot/A0A093HF73 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:PEMT ^@ http://purl.uniprot.org/uniprot/A0A093FN00 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/37040:EFL1 ^@ http://purl.uniprot.org/uniprot/A0A093F1K3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:LOC104257745 ^@ http://purl.uniprot.org/uniprot/A0A093EPL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/37040:LOC104261370 ^@ http://purl.uniprot.org/uniprot/A0A093FK78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/37040:ORMDL2 ^@ http://purl.uniprot.org/uniprot/A0A093FGI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane http://togogenome.org/gene/37040:RPL30 ^@ http://purl.uniprot.org/uniprot/A0A093FD78 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/37040:LOC104257763 ^@ http://purl.uniprot.org/uniprot/A0A093FBP1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:DLST ^@ http://purl.uniprot.org/uniprot/A0A093FXK1 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/37040:B3GALT1 ^@ http://purl.uniprot.org/uniprot/A0A093G032 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/37040:STAM ^@ http://purl.uniprot.org/uniprot/A0A093I292 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane http://togogenome.org/gene/37040:GNG2 ^@ http://purl.uniprot.org/uniprot/A0A093HB42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/37040:PTPN14 ^@ http://purl.uniprot.org/uniprot/A0A093FRF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/37040:CER1 ^@ http://purl.uniprot.org/uniprot/A0A093FYV4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/37040:SDHB ^@ http://purl.uniprot.org/uniprot/A0A093HGN8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/37040:LDAF1 ^@ http://purl.uniprot.org/uniprot/A0A093FB17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/37040:SGCB ^@ http://purl.uniprot.org/uniprot/A0A093HL33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/37040:CPSF2 ^@ http://purl.uniprot.org/uniprot/A0A093F723 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/37040:LSM3 ^@ http://purl.uniprot.org/uniprot/A0A093EWQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/37040:LOC104261212 ^@ http://purl.uniprot.org/uniprot/A0A093FUD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/37040:CAPN6 ^@ http://purl.uniprot.org/uniprot/A0A093F3Z7 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/37040:GJA8 ^@ http://purl.uniprot.org/uniprot/A0A093F5P6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/37040:NPEPL1 ^@ http://purl.uniprot.org/uniprot/A0A093F5X7 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/37040:CDPF1 ^@ http://purl.uniprot.org/uniprot/A0A093EWS8 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/37040:SMAD1 ^@ http://purl.uniprot.org/uniprot/A0A093FG34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/37040:GREM2 ^@ http://purl.uniprot.org/uniprot/A0A093HGS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/37040:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A093EPD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/37040:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A093F4C2 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/37040:PLPP3 ^@ http://purl.uniprot.org/uniprot/A0A093HVM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/37040:PTGS2 ^@ http://purl.uniprot.org/uniprot/A0A093EVG3 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:EFTUD2 ^@ http://purl.uniprot.org/uniprot/A0A093FDU5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:ZNF622 ^@ http://purl.uniprot.org/uniprot/A0A093F584 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/37040:INTS12 ^@ http://purl.uniprot.org/uniprot/A0A093EZI0 ^@ Similarity ^@ Belongs to the Integrator subunit 12 family. http://togogenome.org/gene/37040:LOC104264608 ^@ http://purl.uniprot.org/uniprot/A0A093GW54 ^@ Function|||Similarity ^@ Belongs to the apovitellenin family.|||Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes. http://togogenome.org/gene/37040:IRF8 ^@ http://purl.uniprot.org/uniprot/A0A093FL80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:UHRF1 ^@ http://purl.uniprot.org/uniprot/A0A093I1V0 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/37040:ACE2 ^@ http://purl.uniprot.org/uniprot/A0A093FVX3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/37040:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A093FTV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/37040:ATP5PF ^@ http://purl.uniprot.org/uniprot/A0A093FRX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/37040:EDC3 ^@ http://purl.uniprot.org/uniprot/A0A093HII9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/37040:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A093FZL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/37040:TEKT3 ^@ http://purl.uniprot.org/uniprot/A0A093GYB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/37040:RPL5 ^@ http://purl.uniprot.org/uniprot/A0A093G205 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/37040:ANAPC13 ^@ http://purl.uniprot.org/uniprot/A0A093ERQ3 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/37040:UTS2 ^@ http://purl.uniprot.org/uniprot/A0A093EWP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/37040:KCNA2 ^@ http://purl.uniprot.org/uniprot/A0A093FSA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:C8H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A093H660 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/37040:IFNG ^@ http://purl.uniprot.org/uniprot/A0A093EP72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.|||Secreted http://togogenome.org/gene/37040:EDEM3 ^@ http://purl.uniprot.org/uniprot/A0A093ERD4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/37040:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A093FA31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/37040:GNB4 ^@ http://purl.uniprot.org/uniprot/A0A093HIQ2 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/37040:USP40 ^@ http://purl.uniprot.org/uniprot/A0A093F9N3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/37040:SQLE ^@ http://purl.uniprot.org/uniprot/A0A093FQ13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/37040:KCNE4 ^@ http://purl.uniprot.org/uniprot/A0A093FB80 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/37040:LOC104254176 ^@ http://purl.uniprot.org/uniprot/A0A093F1U0 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/37040:BOD1 ^@ http://purl.uniprot.org/uniprot/A0A093FCH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BOD1 family.|||centrosome|||kinetochore http://togogenome.org/gene/37040:UBIAD1 ^@ http://purl.uniprot.org/uniprot/A0A093F6P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Membrane http://togogenome.org/gene/37040:ORMDL3 ^@ http://purl.uniprot.org/uniprot/A0A093F3C4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/37040:LOC104265118 ^@ http://purl.uniprot.org/uniprot/A0A093F5M5 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/37040:STX18 ^@ http://purl.uniprot.org/uniprot/A0A093FIA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Endoplasmic reticulum membrane|||Membrane|||Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. http://togogenome.org/gene/37040:HDLBP ^@ http://purl.uniprot.org/uniprot/A0A093EY61 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/37040:PKIA ^@ http://purl.uniprot.org/uniprot/A0A093HPE5 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/37040:LOC104264363 ^@ http://purl.uniprot.org/uniprot/A0A093ERD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:PRKCH ^@ http://purl.uniprot.org/uniprot/A0A093F1E0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/37040:SLC26A9 ^@ http://purl.uniprot.org/uniprot/A0A093FQ76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.|||Membrane http://togogenome.org/gene/37040:KCNMB1 ^@ http://purl.uniprot.org/uniprot/A0A093FJS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:LYRM1 ^@ http://purl.uniprot.org/uniprot/A0A093HBB8 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/37040:SERPINF1 ^@ http://purl.uniprot.org/uniprot/A0A093EUM6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/37040:TAGLN3 ^@ http://purl.uniprot.org/uniprot/A0A093GZJ6 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/37040:ACER2 ^@ http://purl.uniprot.org/uniprot/A0A093EW89 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/37040:ARHGDIA ^@ http://purl.uniprot.org/uniprot/A0A093I219 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/37040:AGPAT3 ^@ http://purl.uniprot.org/uniprot/A0A093EZU9 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/37040:FBXO34 ^@ http://purl.uniprot.org/uniprot/A0A093FF30 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/37040:UBA3 ^@ http://purl.uniprot.org/uniprot/A0A093ESB2 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/37040:KDELR3 ^@ http://purl.uniprot.org/uniprot/A0A093FIW6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/37040:RAB38 ^@ http://purl.uniprot.org/uniprot/A0A093G0S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/37040:UCN3 ^@ http://purl.uniprot.org/uniprot/A0A093F8C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/37040:RPS14 ^@ http://purl.uniprot.org/uniprot/A0A093FMN3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/37040:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/A0A093FE16 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/37040:LOC104253334 ^@ http://purl.uniprot.org/uniprot/A0A093H424 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/37040:NPM1 ^@ http://purl.uniprot.org/uniprot/A0A093HG66 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/37040:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/A0A093FU89 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/37040:NFIL3 ^@ http://purl.uniprot.org/uniprot/A0A093EYN1 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/37040:ATOH7 ^@ http://purl.uniprot.org/uniprot/A0A093FC00 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/37040:UNC93A ^@ http://purl.uniprot.org/uniprot/A0A093FAI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/37040:CORT ^@ http://purl.uniprot.org/uniprot/A0A093F4S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/37040:CEP63 ^@ http://purl.uniprot.org/uniprot/A0A093ERG0 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/37040:LOC104262390 ^@ http://purl.uniprot.org/uniprot/A0A093FNM0 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/37040:AP2M1 ^@ http://purl.uniprot.org/uniprot/A0A093H1J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/37040:DTD1 ^@ http://purl.uniprot.org/uniprot/A0A093F192 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/37040:NAA35 ^@ http://purl.uniprot.org/uniprot/A0A093FM75 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/37040:TSHZ2 ^@ http://purl.uniprot.org/uniprot/A0A093FQN5 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/37040:F2 ^@ http://purl.uniprot.org/uniprot/A0A093FNR8 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/37040:DACT2 ^@ http://purl.uniprot.org/uniprot/A0A093GVF8 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/37040:GPC4 ^@ http://purl.uniprot.org/uniprot/A0A093HM11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/37040:HAPLN1 ^@ http://purl.uniprot.org/uniprot/A0A093FQ62 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/37040:OVOL2 ^@ http://purl.uniprot.org/uniprot/A0A093H2R7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A093FJM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/37040:TUBD1 ^@ http://purl.uniprot.org/uniprot/A0A093EVR7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/37040:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A093FKC3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/37040:KCNE1 ^@ http://purl.uniprot.org/uniprot/A0A093F7G6 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the potassium channel KCNE family.|||Cell membrane|||Membrane http://togogenome.org/gene/37040:MFSD10 ^@ http://purl.uniprot.org/uniprot/A0A093FGN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:SMC5 ^@ http://purl.uniprot.org/uniprot/A0A093GY23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/37040:SNU13 ^@ http://purl.uniprot.org/uniprot/A0A093FNS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/37040:MMGT1 ^@ http://purl.uniprot.org/uniprot/A0A093F599 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/37040:HS3ST6 ^@ http://purl.uniprot.org/uniprot/A0A093FKC0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/37040:RPS6 ^@ http://purl.uniprot.org/uniprot/A0A093F3T2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/37040:ZBED4 ^@ http://purl.uniprot.org/uniprot/A0A093H0P3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:GPHB5 ^@ http://purl.uniprot.org/uniprot/A0A093FCF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/37040:PCMTD2 ^@ http://purl.uniprot.org/uniprot/A0A093FLD6 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/37040:HAL ^@ http://purl.uniprot.org/uniprot/A0A093FYC4 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/37040:PRPH2 ^@ http://purl.uniprot.org/uniprot/A0A093F2L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/37040:DRAM2 ^@ http://purl.uniprot.org/uniprot/A0A093F492 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:AFF4 ^@ http://purl.uniprot.org/uniprot/A0A093HR25 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/37040:PEX12 ^@ http://purl.uniprot.org/uniprot/A0A093HGS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/37040:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/A0A093FEC3 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/37040:IP6K2 ^@ http://purl.uniprot.org/uniprot/A0A093HG14 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/37040:LACC1 ^@ http://purl.uniprot.org/uniprot/A0A093F4D8 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/37040:GNG4 ^@ http://purl.uniprot.org/uniprot/A0A093FEM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/37040:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A093FCL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/37040:GCLM ^@ http://purl.uniprot.org/uniprot/A0A093FKR2 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/37040:KPNA1 ^@ http://purl.uniprot.org/uniprot/A0A093F0R9 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/37040:RPS2 ^@ http://purl.uniprot.org/uniprot/A0A093F0H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS5 family.|||Nucleus http://togogenome.org/gene/37040:INTS9 ^@ http://purl.uniprot.org/uniprot/A0A093FC08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:MCM8 ^@ http://purl.uniprot.org/uniprot/A0A093FBH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/37040:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A093FWN5 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/37040:COPB1 ^@ http://purl.uniprot.org/uniprot/A0A093EMW8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/37040:SLC13A4 ^@ http://purl.uniprot.org/uniprot/A0A093HDP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/37040:NEUROD6 ^@ http://purl.uniprot.org/uniprot/A0A093FBU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:ERGIC1 ^@ http://purl.uniprot.org/uniprot/A0A093HBF4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/37040:LOC104254247 ^@ http://purl.uniprot.org/uniprot/A0A093H734 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/37040:TNIP2 ^@ http://purl.uniprot.org/uniprot/A0A093H407 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/37040:SLC16A14 ^@ http://purl.uniprot.org/uniprot/A0A093HP62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:GFOD2 ^@ http://purl.uniprot.org/uniprot/A0A093FWW2 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/37040:SGCD ^@ http://purl.uniprot.org/uniprot/A0A093G0J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/37040:CALHM2 ^@ http://purl.uniprot.org/uniprot/A0A093EX13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/37040:TM4SF18 ^@ http://purl.uniprot.org/uniprot/A0A093FQZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/37040:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A093HY80 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/37040:MTMR6 ^@ http://purl.uniprot.org/uniprot/A0A093F1G1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/37040:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/A0A093FCW4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/37040:LOC104254958 ^@ http://purl.uniprot.org/uniprot/A0A093F1A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/37040:IL7R ^@ http://purl.uniprot.org/uniprot/A0A093H3E6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. http://togogenome.org/gene/37040:KIN ^@ http://purl.uniprot.org/uniprot/A0A093FZ47 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/37040:EDNRA ^@ http://purl.uniprot.org/uniprot/A0A093HEA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/37040:LOC104260586 ^@ http://purl.uniprot.org/uniprot/A0A093FSD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/37040:MLLT11 ^@ http://purl.uniprot.org/uniprot/A0A093F4W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/37040:SLC24A3 ^@ http://purl.uniprot.org/uniprot/A0A093H3V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/37040:ERGIC2 ^@ http://purl.uniprot.org/uniprot/A0A093FPI1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/37040:FDFT1 ^@ http://purl.uniprot.org/uniprot/A0A093F238 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/37040:HVCN1 ^@ http://purl.uniprot.org/uniprot/A0A093H6L5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:REV1 ^@ http://purl.uniprot.org/uniprot/A0A093F548 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/37040:SLC25A20 ^@ http://purl.uniprot.org/uniprot/A0A093F7B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/37040:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A093F0U0 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/37040:MAPK8 ^@ http://purl.uniprot.org/uniprot/A0A093FVT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/37040:LOC104256103 ^@ http://purl.uniprot.org/uniprot/A0A093F7C8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/37040:CNR1 ^@ http://purl.uniprot.org/uniprot/A0A093F777 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Signaling typically involves reduction in cyclic AMP.|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/37040:ALDOB ^@ http://purl.uniprot.org/uniprot/A0A093F4M7 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/37040:TP53INP1 ^@ http://purl.uniprot.org/uniprot/A0A093F5E3 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/37040:APOD ^@ http://purl.uniprot.org/uniprot/A0A093FFH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/37040:ALG12 ^@ http://purl.uniprot.org/uniprot/A0A093F2C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/37040:BASP1 ^@ http://purl.uniprot.org/uniprot/A0A093EN09 ^@ Similarity ^@ Belongs to the BASP1 family. http://togogenome.org/gene/37040:FYN ^@ http://purl.uniprot.org/uniprot/A0A093FDT6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/37040:SLC6A15 ^@ http://purl.uniprot.org/uniprot/A0A093FKN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/37040:PRKCA ^@ http://purl.uniprot.org/uniprot/A0A093FJX9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.|||Cell membrane|||Cytoplasm|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/37040:IRF2 ^@ http://purl.uniprot.org/uniprot/A0A093FAY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/37040:LOC104262983 ^@ http://purl.uniprot.org/uniprot/A0A093FQK4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/37040:BOK ^@ http://purl.uniprot.org/uniprot/A0A093FRI3 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/37040:SPARC ^@ http://purl.uniprot.org/uniprot/A0A093FUA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/37040:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A093F893 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/37040:SORD ^@ http://purl.uniprot.org/uniprot/A0A093FUF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Mitochondrion membrane|||flagellum http://togogenome.org/gene/37040:GNB3 ^@ http://purl.uniprot.org/uniprot/A0A093HG52 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/37040:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A093F1N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/37040:C1GALT1 ^@ http://purl.uniprot.org/uniprot/A0A093FRI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/37040:IL12B ^@ http://purl.uniprot.org/uniprot/A0A093FR25 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-12B family.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/37040:TMEM41A ^@ http://purl.uniprot.org/uniprot/A0A093F2U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/37040:TRAF5 ^@ http://purl.uniprot.org/uniprot/A0A093H522 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/37040:BLCAP ^@ http://purl.uniprot.org/uniprot/A0A093FWM6 ^@ Similarity ^@ Belongs to the BLCAP family. http://togogenome.org/gene/37040:STX17 ^@ http://purl.uniprot.org/uniprot/A0A093F9Q9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/37040:CHRNA9 ^@ http://purl.uniprot.org/uniprot/A0A093F0E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/37040:MED7 ^@ http://purl.uniprot.org/uniprot/A0A093FFI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/37040:TARDBP ^@ http://purl.uniprot.org/uniprot/A0A093FJ08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/37040:GIMD1 ^@ http://purl.uniprot.org/uniprot/A0A093G0L5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/37040:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/A0A093FG01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/37040:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/A0A093HRR0 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/37040:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A093H624 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/37040:CHRM2 ^@ http://purl.uniprot.org/uniprot/A0A093F4P7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.