http://togogenome.org/gene/434131:NRI_RS00555 ^@ http://purl.uniprot.org/uniprot/C6V413 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/434131:NRI_RS04015 ^@ http://purl.uniprot.org/uniprot/C6V673 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS01785 ^@ http://purl.uniprot.org/uniprot/C6V4S4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/434131:NRI_RS02770 ^@ http://purl.uniprot.org/uniprot/C6V5F0 ^@ Similarity ^@ Belongs to the Skp family. http://togogenome.org/gene/434131:NRI_RS01770 ^@ http://purl.uniprot.org/uniprot/C6V4S1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell inner membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/434131:NRI_RS02925 ^@ http://purl.uniprot.org/uniprot/C6V5I4 ^@ Function ^@ Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/434131:NRI_RS00965 ^@ http://purl.uniprot.org/uniprot/C6V499 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/434131:NRI_RS01965 ^@ http://purl.uniprot.org/uniprot/C6V4W6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/434131:NRI_RS02310 ^@ http://purl.uniprot.org/uniprot/C6V541 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/434131:NRI_RS04040 ^@ http://purl.uniprot.org/uniprot/C6V678 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/434131:NRI_RS03185 ^@ http://purl.uniprot.org/uniprot/C6V5N9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/434131:NRI_RS03830 ^@ http://purl.uniprot.org/uniprot/C6V631 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/434131:NRI_RS02955 ^@ http://purl.uniprot.org/uniprot/C6V5J0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS03990 ^@ http://purl.uniprot.org/uniprot/C6V667 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/434131:NRI_RS01535 ^@ http://purl.uniprot.org/uniprot/C6V4L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/434131:NRI_RS02810 ^@ http://purl.uniprot.org/uniprot/C6V5G0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.|||Single-chain monomer with multiple functions. http://togogenome.org/gene/434131:NRI_RS02835 ^@ http://purl.uniprot.org/uniprot/C6V5G6 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. http://togogenome.org/gene/434131:NRI_RS03225 ^@ http://purl.uniprot.org/uniprot/C6V5P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS02880 ^@ http://purl.uniprot.org/uniprot/C6V5H4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/434131:NRI_RS01830 ^@ http://purl.uniprot.org/uniprot/C6V4T4 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS01185 ^@ http://purl.uniprot.org/uniprot/C6V4E3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/434131:NRI_RS02500 ^@ http://purl.uniprot.org/uniprot/C6V584 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein. http://togogenome.org/gene/434131:NRI_RS00045 ^@ http://purl.uniprot.org/uniprot/C6V3P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/434131:NRI_RS00290 ^@ http://purl.uniprot.org/uniprot/C6V3U8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS02245 ^@ http://purl.uniprot.org/uniprot/C6V528 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/434131:NRI_RS01710 ^@ http://purl.uniprot.org/uniprot/C6V4Q6 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/434131:NRI_RS03495 ^@ http://purl.uniprot.org/uniprot/C6V5V9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/434131:NRI_RS01220 ^@ http://purl.uniprot.org/uniprot/C6V4F0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/434131:NRI_RS00670 ^@ http://purl.uniprot.org/uniprot/C6V438 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. HflK subfamily.|||HflC and HflK could encode or regulate a protease.|||HflC and HflK may interact to form a multimeric complex.|||Membrane http://togogenome.org/gene/434131:NRI_RS03615 ^@ http://purl.uniprot.org/uniprot/C6V5Y4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS01660 ^@ http://purl.uniprot.org/uniprot/C6V4P6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/434131:NRI_RS00900 ^@ http://purl.uniprot.org/uniprot/C6V485 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/434131:NRI_RS01920 ^@ http://purl.uniprot.org/uniprot/C6V4V6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/434131:NRI_RS01115 ^@ http://purl.uniprot.org/uniprot/C6V4C9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/434131:NRI_RS01285 ^@ http://purl.uniprot.org/uniprot/C6V4G3 ^@ Similarity ^@ Belongs to the HesB/IscA family. http://togogenome.org/gene/434131:NRI_RS02935 ^@ http://purl.uniprot.org/uniprot/C6V5I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS01680 ^@ http://purl.uniprot.org/uniprot/C6V4Q0 ^@ Caution|||Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS00740 ^@ http://purl.uniprot.org/uniprot/C6V450 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|||Cell membrane http://togogenome.org/gene/434131:NRI_RS01190 ^@ http://purl.uniprot.org/uniprot/C6V4E4 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL6 family.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/434131:NRI_RS01715 ^@ http://purl.uniprot.org/uniprot/C6V4Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane|||Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/434131:NRI_RS01345 ^@ http://purl.uniprot.org/uniprot/C6V4H6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/434131:NRI_RS02875 ^@ http://purl.uniprot.org/uniprot/C6V5H3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/434131:NRI_RS00385 ^@ http://purl.uniprot.org/uniprot/C6V3X2 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/434131:NRI_RS02895 ^@ http://purl.uniprot.org/uniprot/C6V5H7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 2 family.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/434131:NRI_RS01655 ^@ http://purl.uniprot.org/uniprot/C6V4P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell inner membrane|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/434131:NRI_RS03965 ^@ http://purl.uniprot.org/uniprot/C6V660 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvC family.|||Binds 2 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/434131:NRI_RS00270 ^@ http://purl.uniprot.org/uniprot/C6V3U4 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/434131:NRI_RS00760 ^@ http://purl.uniprot.org/uniprot/C6V456 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/434131:NRI_RS03285 ^@ http://purl.uniprot.org/uniprot/C6V5R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS03415 ^@ http://purl.uniprot.org/uniprot/C6V5U0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/434131:NRI_RS03745 ^@ http://purl.uniprot.org/uniprot/C6V613 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/434131:NRI_RS02775 ^@ http://purl.uniprot.org/uniprot/C6V5F1 ^@ Function|||Subunit ^@ Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/434131:NRI_RS00850 ^@ http://purl.uniprot.org/uniprot/C6V475 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/434131:NRI_RS01840 ^@ http://purl.uniprot.org/uniprot/C6V4T8 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/434131:NRI_RS03950 ^@ http://purl.uniprot.org/uniprot/C6V657 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). http://togogenome.org/gene/434131:NRI_RS00895 ^@ http://purl.uniprot.org/uniprot/C6V484 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/434131:NRI_RS00725 ^@ http://purl.uniprot.org/uniprot/C6V447 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/434131:NRI_RS03755 ^@ http://purl.uniprot.org/uniprot/C6V615 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/434131:NRI_RS02535 ^@ http://purl.uniprot.org/uniprot/C6V592 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/434131:NRI_RS01015 ^@ http://purl.uniprot.org/uniprot/C6V4B2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/434131:NRI_RS03055 ^@ http://purl.uniprot.org/uniprot/C6V5L2 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/434131:NRI_RS02055 ^@ http://purl.uniprot.org/uniprot/C6V4Y5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell inner membrane|||Membrane http://togogenome.org/gene/434131:NRI_RS01170 ^@ http://purl.uniprot.org/uniprot/C6V4E0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/434131:NRI_RS01805 ^@ http://purl.uniprot.org/uniprot/C6V4S7 ^@ Similarity ^@ Belongs to the phosphoglycerate kinase family. http://togogenome.org/gene/434131:NRI_RS03080 ^@ http://purl.uniprot.org/uniprot/C6V5L8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/434131:NRI_RS02480 ^@ http://purl.uniprot.org/uniprot/C6V579 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/434131:NRI_RS03840 ^@ http://purl.uniprot.org/uniprot/C6V633 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/434131:NRI_RS03945 ^@ http://purl.uniprot.org/uniprot/C6V655 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/434131:NRI_RS03335 ^@ http://purl.uniprot.org/uniprot/C6V5S4 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/434131:NRI_RS03450 ^@ http://purl.uniprot.org/uniprot/C6V5V0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/434131:NRI_RS03555 ^@ http://purl.uniprot.org/uniprot/C6V5X1 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/434131:NRI_RS04020 ^@ http://purl.uniprot.org/uniprot/C6V674 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/434131:NRI_RS03040 ^@ http://purl.uniprot.org/uniprot/C6V5K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/434131:NRI_RS01215 ^@ http://purl.uniprot.org/uniprot/C6V4E9 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/434131:NRI_RS02230 ^@ http://purl.uniprot.org/uniprot/C6V525 ^@ Similarity|||Subunit ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein. http://togogenome.org/gene/434131:NRI_RS02905 ^@ http://purl.uniprot.org/uniprot/C6V5H9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/434131:NRI_RS01140 ^@ http://purl.uniprot.org/uniprot/C6V4D4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/434131:NRI_RS00920 ^@ http://purl.uniprot.org/uniprot/C6V489 ^@ Similarity ^@ Belongs to the CarB family. http://togogenome.org/gene/434131:NRI_RS01270 ^@ http://purl.uniprot.org/uniprot/C6V4F9 ^@ Function|||Similarity ^@ Belongs to the adrenodoxin/putidaredoxin family.|||Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/434131:NRI_RS01510 ^@ http://purl.uniprot.org/uniprot/C6V4L2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/434131:NRI_RS00865 ^@ http://purl.uniprot.org/uniprot/C6V478 ^@ Similarity ^@ Belongs to the TrbG/VirB9 family. http://togogenome.org/gene/434131:NRI_RS03165 ^@ http://purl.uniprot.org/uniprot/C6V5N5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/434131:NRI_RS00820 ^@ http://purl.uniprot.org/uniprot/C6V469 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/434131:NRI_RS01305 ^@ http://purl.uniprot.org/uniprot/C6V4G7 ^@ Subcellular Location Annotation ^@ Cell inner membrane http://togogenome.org/gene/434131:NRI_RS00700 ^@ http://purl.uniprot.org/uniprot/C6V443 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/434131:NRI_RS00225 ^@ http://purl.uniprot.org/uniprot/C6V3T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Cell inner membrane|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. http://togogenome.org/gene/434131:NRI_RS01055 ^@ http://purl.uniprot.org/uniprot/C6V4B9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/434131:NRI_RS00935 ^@ http://purl.uniprot.org/uniprot/C6V492 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/434131:NRI_RS02215 ^@ http://purl.uniprot.org/uniprot/C6V522 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS01200 ^@ http://purl.uniprot.org/uniprot/C6V4E6 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. http://togogenome.org/gene/434131:NRI_RS02130 ^@ http://purl.uniprot.org/uniprot/C6V500 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS01935 ^@ http://purl.uniprot.org/uniprot/C6V4V9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS02780 ^@ http://purl.uniprot.org/uniprot/C6V5F3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/434131:NRI_RS00080 ^@ http://purl.uniprot.org/uniprot/C6V3Q0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS01470 ^@ http://purl.uniprot.org/uniprot/C6V4K4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/434131:NRI_RS00890 ^@ http://purl.uniprot.org/uniprot/C6V483 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/434131:NRI_RS02555 ^@ http://purl.uniprot.org/uniprot/C6V598 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily.|||Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. http://togogenome.org/gene/434131:NRI_RS01695 ^@ http://purl.uniprot.org/uniprot/C6V4Q3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/434131:NRI_RS03510 ^@ http://purl.uniprot.org/uniprot/C6V5W2 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site. http://togogenome.org/gene/434131:NRI_RS00675 ^@ http://purl.uniprot.org/uniprot/C6V439 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/434131:NRI_RS02600 ^@ http://purl.uniprot.org/uniprot/C6V5A6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/434131:NRI_RS01230 ^@ http://purl.uniprot.org/uniprot/C6V4F2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/434131:NRI_RS02505 ^@ http://purl.uniprot.org/uniprot/C6V585 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/434131:NRI_RS00050 ^@ http://purl.uniprot.org/uniprot/C6V3P2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/434131:NRI_RS03650 ^@ http://purl.uniprot.org/uniprot/C6V5Z3 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS03360 ^@ http://purl.uniprot.org/uniprot/C6V5S9 ^@ Function ^@ Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/434131:NRI_RS02175 ^@ http://purl.uniprot.org/uniprot/C6V512 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/434131:NRI_RS00515 ^@ http://purl.uniprot.org/uniprot/C6V404 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/434131:NRI_RS02615 ^@ http://purl.uniprot.org/uniprot/C6V5A9 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. UbiG/COQ3 family.|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/434131:NRI_RS02510 ^@ http://purl.uniprot.org/uniprot/C6V586 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/434131:NRI_RS02815 ^@ http://purl.uniprot.org/uniprot/C6V5G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/434131:NRI_RS01810 ^@ http://purl.uniprot.org/uniprot/C6V4S8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/434131:NRI_RS02260 ^@ http://purl.uniprot.org/uniprot/C6V531 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Cell inner membrane|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS00980 ^@ http://purl.uniprot.org/uniprot/C6V4A3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/434131:NRI_RS00560 ^@ http://purl.uniprot.org/uniprot/C6V414 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/434131:NRI_RS03115 ^@ http://purl.uniprot.org/uniprot/C6V5M6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. http://togogenome.org/gene/434131:NRI_RS03935 ^@ http://purl.uniprot.org/uniprot/C6V653 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS03915 ^@ http://purl.uniprot.org/uniprot/C6V649 ^@ Similarity ^@ Belongs to the SdhE FAD assembly factor family. http://togogenome.org/gene/434131:NRI_RS01915 ^@ http://purl.uniprot.org/uniprot/C6V4V5 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/434131:NRI_RS03100 ^@ http://purl.uniprot.org/uniprot/C6V5M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TrbI/VirB10 family.|||Membrane http://togogenome.org/gene/434131:NRI_RS02005 ^@ http://purl.uniprot.org/uniprot/C6V4X4 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/434131:NRI_RS01205 ^@ http://purl.uniprot.org/uniprot/C6V4E7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/434131:NRI_RS02665 ^@ http://purl.uniprot.org/uniprot/C6V5C1 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/434131:NRI_RS02410 ^@ http://purl.uniprot.org/uniprot/C6V562 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/434131:NRI_RS03095 ^@ http://purl.uniprot.org/uniprot/C6V5M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP E family.|||Cytoplasm|||Part of the Type IV secretion system. http://togogenome.org/gene/434131:NRI_RS00255 ^@ http://purl.uniprot.org/uniprot/C6V3U1 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/434131:NRI_RS00735 ^@ http://purl.uniprot.org/uniprot/C6V449 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/434131:NRI_RS01130 ^@ http://purl.uniprot.org/uniprot/C6V4D2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/434131:NRI_RS03600 ^@ http://purl.uniprot.org/uniprot/C6V5Y1 ^@ Similarity ^@ Belongs to the TrbE/VirB4 family. http://togogenome.org/gene/434131:NRI_RS00025 ^@ http://purl.uniprot.org/uniprot/C6V3N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 1 family.|||Periplasm http://togogenome.org/gene/434131:NRI_RS04000 ^@ http://purl.uniprot.org/uniprot/C6V669 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/434131:NRI_RS00710 ^@ http://purl.uniprot.org/uniprot/C6V444 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/434131:NRI_RS03380 ^@ http://purl.uniprot.org/uniprot/C6V5T2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/434131:NRI_RS03065 ^@ http://purl.uniprot.org/uniprot/C6V5L4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/434131:NRI_RS03190 ^@ http://purl.uniprot.org/uniprot/C6V5P0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS01420 ^@ http://purl.uniprot.org/uniprot/C6V4J3 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/434131:NRI_RS03220 ^@ http://purl.uniprot.org/uniprot/C6V5P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell inner membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/434131:NRI_RS03800 ^@ http://purl.uniprot.org/uniprot/C6V625 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/434131:NRI_RS03070 ^@ http://purl.uniprot.org/uniprot/C6V5L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/434131:NRI_RS01125 ^@ http://purl.uniprot.org/uniprot/C6V4D1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/434131:NRI_RS00835 ^@ http://purl.uniprot.org/uniprot/C6V472 ^@ Similarity ^@ Belongs to the glutaredoxin family. Monothiol subfamily. http://togogenome.org/gene/434131:NRI_RS01150 ^@ http://purl.uniprot.org/uniprot/C6V4D6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/434131:NRI_RS02990 ^@ http://purl.uniprot.org/uniprot/C6V5J9 ^@ Function|||Similarity ^@ Belongs to the complex I 51 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/434131:NRI_RS00565 ^@ http://purl.uniprot.org/uniprot/C6V416 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/434131:NRI_RS00715 ^@ http://purl.uniprot.org/uniprot/C6V445 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS01165 ^@ http://purl.uniprot.org/uniprot/C6V4D9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/434131:NRI_RS03970 ^@ http://purl.uniprot.org/uniprot/C6V661 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 3 family.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/434131:NRI_RS00005 ^@ http://purl.uniprot.org/uniprot/C6V3N3 ^@ Function|||Similarity ^@ Belongs to the ParB family.|||Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication. http://togogenome.org/gene/434131:NRI_RS02795 ^@ http://purl.uniprot.org/uniprot/C6V5F7 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/434131:NRI_RS00570 ^@ http://purl.uniprot.org/uniprot/C6V417 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS01075 ^@ http://purl.uniprot.org/uniprot/C6V4C3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX11/CtaG family.|||Cell inner membrane|||Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. http://togogenome.org/gene/434131:NRI_RS03015 ^@ http://purl.uniprot.org/uniprot/C6V5K4 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/434131:NRI_RS02375 ^@ http://purl.uniprot.org/uniprot/C6V552 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 49 kDa subunit family.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/434131:NRI_RS02390 ^@ http://purl.uniprot.org/uniprot/C6V557 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/434131:NRI_RS03845 ^@ http://purl.uniprot.org/uniprot/C6V634 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS00840 ^@ http://purl.uniprot.org/uniprot/C6V473 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell inner membrane|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/434131:NRI_RS01210 ^@ http://purl.uniprot.org/uniprot/C6V4E8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/434131:NRI_RS02580 ^@ http://purl.uniprot.org/uniprot/C6V5A2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Cell membrane|||Membrane|||Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). http://togogenome.org/gene/434131:NRI_RS00830 ^@ http://purl.uniprot.org/uniprot/C6V471 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/434131:NRI_RS02000 ^@ http://purl.uniprot.org/uniprot/C6V4X3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/434131:NRI_RS00995 ^@ http://purl.uniprot.org/uniprot/C6V4A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/434131:NRI_RS02825 ^@ http://purl.uniprot.org/uniprot/C6V5G4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/434131:NRI_RS03010 ^@ http://purl.uniprot.org/uniprot/C6V5K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/434131:NRI_RS01645 ^@ http://purl.uniprot.org/uniprot/C6V4P3 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/434131:NRI_RS03805 ^@ http://purl.uniprot.org/uniprot/C6V626 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/434131:NRI_RS03390 ^@ http://purl.uniprot.org/uniprot/C6V5T4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS01245 ^@ http://purl.uniprot.org/uniprot/C6V4F5 ^@ Function|||Subcellular Location Annotation ^@ Cell inner membrane|||Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). http://togogenome.org/gene/434131:NRI_RS03350 ^@ http://purl.uniprot.org/uniprot/C6V5S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.|||Cell inner membrane http://togogenome.org/gene/434131:NRI_RS02270 ^@ http://purl.uniprot.org/uniprot/C6V533 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS00640 ^@ http://purl.uniprot.org/uniprot/C6V432 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS00055 ^@ http://purl.uniprot.org/uniprot/C6V3P3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell inner membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/434131:NRI_RS03690 ^@ http://purl.uniprot.org/uniprot/C6V602 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. http://togogenome.org/gene/434131:NRI_RS02865 ^@ http://purl.uniprot.org/uniprot/C6V5H1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/434131:NRI_RS01145 ^@ http://purl.uniprot.org/uniprot/C6V4D5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/434131:NRI_RS01500 ^@ http://purl.uniprot.org/uniprot/C6V4L0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HemJ family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/434131:NRI_RS00795 ^@ http://purl.uniprot.org/uniprot/C6V463 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/434131:NRI_RS02115 ^@ http://purl.uniprot.org/uniprot/C6V4Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmC/CycZ/HelC family.|||Membrane|||Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. http://togogenome.org/gene/434131:NRI_RS03300 ^@ http://purl.uniprot.org/uniprot/C6V5R6 ^@ Function|||Similarity ^@ Belongs to the OMP decarboxylase family.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). http://togogenome.org/gene/434131:NRI_RS03150 ^@ http://purl.uniprot.org/uniprot/C6V5N2 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/434131:NRI_RS03735 ^@ http://purl.uniprot.org/uniprot/C6V611 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/434131:NRI_RS03890 ^@ http://purl.uniprot.org/uniprot/C6V644 ^@ Similarity ^@ Belongs to the MlaA family. http://togogenome.org/gene/434131:NRI_RS01525 ^@ http://purl.uniprot.org/uniprot/C6V4L7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecB family.|||Cytoplasm|||Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.|||One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. http://togogenome.org/gene/434131:NRI_RS03995 ^@ http://purl.uniprot.org/uniprot/C6V668 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/434131:NRI_RS03645 ^@ http://purl.uniprot.org/uniprot/C6V5Z2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/434131:NRI_RS02585 ^@ http://purl.uniprot.org/uniprot/C6V5A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Cell membrane|||Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.|||Membrane http://togogenome.org/gene/434131:NRI_RS02300 ^@ http://purl.uniprot.org/uniprot/C6V539 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). http://togogenome.org/gene/434131:NRI_RS00115 ^@ http://purl.uniprot.org/uniprot/C6V3R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS01760 ^@ http://purl.uniprot.org/uniprot/C6V4R9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/434131:NRI_RS02120 ^@ http://purl.uniprot.org/uniprot/C6V4Z8 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/434131:NRI_RS01445 ^@ http://purl.uniprot.org/uniprot/C6V4J9 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS02415 ^@ http://purl.uniprot.org/uniprot/C6V563 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/434131:NRI_RS02625 ^@ http://purl.uniprot.org/uniprot/C6V5B2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/434131:NRI_RS01490 ^@ http://purl.uniprot.org/uniprot/C6V4K8 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/434131:NRI_RS00075 ^@ http://purl.uniprot.org/uniprot/C6V3P9 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/434131:NRI_RS01480 ^@ http://purl.uniprot.org/uniprot/C6V4K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/434131:NRI_RS03500 ^@ http://purl.uniprot.org/uniprot/C6V5W0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS03715 ^@ http://purl.uniprot.org/uniprot/C6V607 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/434131:NRI_RS01745 ^@ http://purl.uniprot.org/uniprot/C6V4R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/434131:NRI_RS03595 ^@ http://purl.uniprot.org/uniprot/C6V5Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TrbL/VirB6 family.|||Cell membrane|||Membrane http://togogenome.org/gene/434131:NRI_RS00125 ^@ http://purl.uniprot.org/uniprot/C6V3R4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/434131:NRI_RS01610 ^@ http://purl.uniprot.org/uniprot/C6V4N6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. http://togogenome.org/gene/434131:NRI_RS00250 ^@ http://purl.uniprot.org/uniprot/C6V3U0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/434131:NRI_RS03730 ^@ http://purl.uniprot.org/uniprot/C6V610 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/434131:NRI_RS03160 ^@ http://purl.uniprot.org/uniprot/C6V5N4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/434131:NRI_RS00930 ^@ http://purl.uniprot.org/uniprot/C6V491 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/434131:NRI_RS00265 ^@ http://purl.uniprot.org/uniprot/C6V3U3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/434131:NRI_RS01400 ^@ http://purl.uniprot.org/uniprot/C6V4I9 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/434131:NRI_RS03000 ^@ http://purl.uniprot.org/uniprot/C6V5K1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS01690 ^@ http://purl.uniprot.org/uniprot/C6V4Q2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS02640 ^@ http://purl.uniprot.org/uniprot/C6V5B4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/434131:NRI_RS01835 ^@ http://purl.uniprot.org/uniprot/C6V4T6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/434131:NRI_RS03975 ^@ http://purl.uniprot.org/uniprot/C6V663 ^@ Caution|||Function|||Similarity ^@ Belongs to the dUTPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/434131:NRI_RS02295 ^@ http://purl.uniprot.org/uniprot/C6V538 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/434131:NRI_RS02030 ^@ http://purl.uniprot.org/uniprot/C6V4Y0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/434131:NRI_RS00170 ^@ http://purl.uniprot.org/uniprot/C6V3S3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.|||Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism.|||Homotetramer. http://togogenome.org/gene/434131:NRI_RS01440 ^@ http://purl.uniprot.org/uniprot/C6V4J8 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/434131:NRI_RS02040 ^@ http://purl.uniprot.org/uniprot/C6V4Y2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/434131:NRI_RS02565 ^@ http://purl.uniprot.org/uniprot/C6V5A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/434131:NRI_RS03870 ^@ http://purl.uniprot.org/uniprot/C6V639 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/434131:NRI_RS02450 ^@ http://purl.uniprot.org/uniprot/C6V570 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/434131:NRI_RS03525 ^@ http://purl.uniprot.org/uniprot/C6V5W5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS02670 ^@ http://purl.uniprot.org/uniprot/C6V5C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS02840 ^@ http://purl.uniprot.org/uniprot/C6V5G7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/434131:NRI_RS01910 ^@ http://purl.uniprot.org/uniprot/C6V4V4 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/434131:NRI_RS02985 ^@ http://purl.uniprot.org/uniprot/C6V5J7 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/434131:NRI_RS02010 ^@ http://purl.uniprot.org/uniprot/C6V4X5 ^@ Function|||Similarity ^@ Belongs to the HPPK family.|||Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway. http://togogenome.org/gene/434131:NRI_RS03790 ^@ http://purl.uniprot.org/uniprot/C6V622 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/434131:NRI_RS00200 ^@ http://purl.uniprot.org/uniprot/C6V3S9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/434131:NRI_RS02080 ^@ http://purl.uniprot.org/uniprot/C6V4Z0 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/434131:NRI_RS02235 ^@ http://purl.uniprot.org/uniprot/C6V526 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/434131:NRI_RS02610 ^@ http://purl.uniprot.org/uniprot/C6V5A8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell inner membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/434131:NRI_RS02085 ^@ http://purl.uniprot.org/uniprot/C6V4Z1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/434131:NRI_RS01600 ^@ http://purl.uniprot.org/uniprot/C6V4N4 ^@ Function ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. http://togogenome.org/gene/434131:NRI_RS02650 ^@ http://purl.uniprot.org/uniprot/C6V5B6 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/434131:NRI_RS00815 ^@ http://purl.uniprot.org/uniprot/C6V468 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS01685 ^@ http://purl.uniprot.org/uniprot/C6V4Q1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell inner membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/434131:NRI_RS03170 ^@ http://purl.uniprot.org/uniprot/C6V5N6 ^@ Function|||Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes the reversible conversion of aspartate and 2-oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of glutamate. http://togogenome.org/gene/434131:NRI_RS01960 ^@ http://purl.uniprot.org/uniprot/C6V4W5 ^@ Caution|||Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS02170 ^@ http://purl.uniprot.org/uniprot/C6V511 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/434131:NRI_RS02335 ^@ http://purl.uniprot.org/uniprot/C6V545 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/434131:NRI_RS03175 ^@ http://purl.uniprot.org/uniprot/C6V5N7 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/434131:NRI_RS03140 ^@ http://purl.uniprot.org/uniprot/C6V5N0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/434131:NRI_RS01485 ^@ http://purl.uniprot.org/uniprot/C6V4K7 ^@ Function|||Similarity ^@ Belongs to the bacterioferritin family.|||Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. http://togogenome.org/gene/434131:NRI_RS03325 ^@ http://purl.uniprot.org/uniprot/C6V5S2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/434131:NRI_RS01275 ^@ http://purl.uniprot.org/uniprot/C6V4G0 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/434131:NRI_RS03445 ^@ http://purl.uniprot.org/uniprot/C6V5U9 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/434131:NRI_RS02950 ^@ http://purl.uniprot.org/uniprot/C6V5I9 ^@ Similarity ^@ Belongs to the transketolase family. http://togogenome.org/gene/434131:NRI_RS01290 ^@ http://purl.uniprot.org/uniprot/C6V4G4 ^@ Function|||Similarity ^@ A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.|||Belongs to the NifU family. http://togogenome.org/gene/434131:NRI_RS03610 ^@ http://purl.uniprot.org/uniprot/C6V5Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane|||Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/434131:NRI_RS02695 ^@ http://purl.uniprot.org/uniprot/C6V5C8 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/434131:NRI_RS03480 ^@ http://purl.uniprot.org/uniprot/C6V5V6 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/434131:NRI_RS01990 ^@ http://purl.uniprot.org/uniprot/C6V4X0 ^@ Function ^@ Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/434131:NRI_RS03860 ^@ http://purl.uniprot.org/uniprot/C6V637 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/434131:NRI_RS02675 ^@ http://purl.uniprot.org/uniprot/C6V5C3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/434131:NRI_RS02940 ^@ http://purl.uniprot.org/uniprot/C6V5I7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/434131:NRI_RS01035 ^@ http://purl.uniprot.org/uniprot/C6V4B6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/434131:NRI_RS01890 ^@ http://purl.uniprot.org/uniprot/C6V4U9 ^@ Similarity ^@ Belongs to the dGTPase family. Type 2 subfamily. http://togogenome.org/gene/434131:NRI_RS02330 ^@ http://purl.uniprot.org/uniprot/C6V544 ^@ Similarity ^@ Belongs to the pseudouridine synthase RluA family. http://togogenome.org/gene/434131:NRI_RS03455 ^@ http://purl.uniprot.org/uniprot/C6V5V1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CcmE/CycJ family.|||Cell inner membrane|||Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. http://togogenome.org/gene/434131:NRI_RS03885 ^@ http://purl.uniprot.org/uniprot/C6V643 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/434131:NRI_RS02460 ^@ http://purl.uniprot.org/uniprot/C6V573 ^@ Subunit ^@ Toroid-shaped homodecamer, composed of two pentamers of five dimers. http://togogenome.org/gene/434131:NRI_RS01040 ^@ http://purl.uniprot.org/uniprot/C6V4B7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/434131:NRI_RS03240 ^@ http://purl.uniprot.org/uniprot/C6V5Q2 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS01605 ^@ http://purl.uniprot.org/uniprot/C6V4N5 ^@ Similarity ^@ Belongs to the UbiH/COQ6 family. http://togogenome.org/gene/434131:NRI_RS00540 ^@ http://purl.uniprot.org/uniprot/C6V409 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/434131:NRI_RS00355 ^@ http://purl.uniprot.org/uniprot/C6V3W4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/434131:NRI_RS01175 ^@ http://purl.uniprot.org/uniprot/C6V4E1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/434131:NRI_RS03490 ^@ http://purl.uniprot.org/uniprot/C6V5V8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/434131:NRI_RS03250 ^@ http://purl.uniprot.org/uniprot/C6V5Q4 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/434131:NRI_RS01030 ^@ http://purl.uniprot.org/uniprot/C6V4B5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/434131:NRI_RS03700 ^@ http://purl.uniprot.org/uniprot/C6V604 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/434131:NRI_RS01390 ^@ http://purl.uniprot.org/uniprot/C6V4I7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS03090 ^@ http://purl.uniprot.org/uniprot/C6V5M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VirD4/TraG family.|||Membrane http://togogenome.org/gene/434131:NRI_RS00140 ^@ http://purl.uniprot.org/uniprot/C6V3R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/434131:NRI_RS00155 ^@ http://purl.uniprot.org/uniprot/C6V3S0 ^@ Function|||Similarity ^@ Belongs to the ribF family.|||Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. http://togogenome.org/gene/434131:NRI_RS02190 ^@ http://purl.uniprot.org/uniprot/C6V517 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/434131:NRI_RS01360 ^@ http://purl.uniprot.org/uniprot/C6V4H9 ^@ Function ^@ Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/434131:NRI_RS02545 ^@ http://purl.uniprot.org/uniprot/C6V596 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/434131:NRI_RS00765 ^@ http://purl.uniprot.org/uniprot/C6V457 ^@ Similarity ^@ Belongs to the prokaryotic GSH synthase family. http://togogenome.org/gene/434131:NRI_RS03195 ^@ http://purl.uniprot.org/uniprot/C6V5P1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/434131:NRI_RS01070 ^@ http://purl.uniprot.org/uniprot/C6V4C2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/434131:NRI_RS02605 ^@ http://purl.uniprot.org/uniprot/C6V5A7 ^@ Cofactor ^@ Binds 1 heme c group covalently per subunit. http://togogenome.org/gene/434131:NRI_RS00580 ^@ http://purl.uniprot.org/uniprot/C6V419 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.|||Membrane http://togogenome.org/gene/434131:NRI_RS01790 ^@ http://purl.uniprot.org/uniprot/C6V4S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 30 kDa subunit family.|||Cell inner membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/434131:NRI_RS02540 ^@ http://purl.uniprot.org/uniprot/C6V594 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/434131:NRI_RS01670 ^@ http://purl.uniprot.org/uniprot/C6V4P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase B chain family.|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Membrane http://togogenome.org/gene/434131:NRI_RS01765 ^@ http://purl.uniprot.org/uniprot/C6V4S0 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/434131:NRI_RS03925 ^@ http://purl.uniprot.org/uniprot/C6V651 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS02705 ^@ http://purl.uniprot.org/uniprot/C6V5D1 ^@ Function ^@ Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. http://togogenome.org/gene/434131:NRI_RS01995 ^@ http://purl.uniprot.org/uniprot/C6V4X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell inner membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/434131:NRI_RS02250 ^@ http://purl.uniprot.org/uniprot/C6V529 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/434131:NRI_RS01020 ^@ http://purl.uniprot.org/uniprot/C6V4B3 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/434131:NRI_RS00635 ^@ http://purl.uniprot.org/uniprot/C6V430 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/434131:NRI_RS02845 ^@ http://purl.uniprot.org/uniprot/C6V5G8 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/434131:NRI_RS01225 ^@ http://purl.uniprot.org/uniprot/C6V4F1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/434131:NRI_RS00165 ^@ http://purl.uniprot.org/uniprot/C6V3S2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Membrane|||Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/434131:NRI_RS02485 ^@ http://purl.uniprot.org/uniprot/C6V581 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/434131:NRI_RS00300 ^@ http://purl.uniprot.org/uniprot/C6V3V0 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/434131:NRI_RS03085 ^@ http://purl.uniprot.org/uniprot/C6V5L9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell inner membrane|||Probably interacts with PlsX. http://togogenome.org/gene/434131:NRI_RS01180 ^@ http://purl.uniprot.org/uniprot/C6V4E2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/434131:NRI_RS01650 ^@ http://purl.uniprot.org/uniprot/C6V4P4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS03255 ^@ http://purl.uniprot.org/uniprot/C6V5Q5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS01705 ^@ http://purl.uniprot.org/uniprot/C6V4Q5 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS1 family.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/434131:NRI_RS01560 ^@ http://purl.uniprot.org/uniprot/C6V4M4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the reversible phosphorylation of pyruvate and phosphate.|||Homodimer. http://togogenome.org/gene/434131:NRI_RS03295 ^@ http://purl.uniprot.org/uniprot/C6V5R4 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/434131:NRI_RS01675 ^@ http://purl.uniprot.org/uniprot/C6V4P9 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/434131:NRI_RS03030 ^@ http://purl.uniprot.org/uniprot/C6V5K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/434131:NRI_RS02595 ^@ http://purl.uniprot.org/uniprot/C6V5A5 ^@ Cofactor|||Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit ^@ Binds 1 [2Fe-2S] cluster per subunit.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.|||Membrane|||The Rieske protein is a high potential 2Fe-2S protein.|||The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. http://togogenome.org/gene/434131:NRI_RS02015 ^@ http://purl.uniprot.org/uniprot/C6V4X6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/434131:NRI_RS01395 ^@ http://purl.uniprot.org/uniprot/C6V4I8 ^@ Similarity ^@ Belongs to the ribosome association toxin RatA family. http://togogenome.org/gene/434131:NRI_RS01160 ^@ http://purl.uniprot.org/uniprot/C6V4D8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/434131:NRI_RS02360 ^@ http://purl.uniprot.org/uniprot/C6V549 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/434131:NRI_RS01295 ^@ http://purl.uniprot.org/uniprot/C6V4G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.|||Cytoplasm|||Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.|||Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. http://togogenome.org/gene/434131:NRI_RS03930 ^@ http://purl.uniprot.org/uniprot/C6V652 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/434131:NRI_RS03670 ^@ http://purl.uniprot.org/uniprot/C6V5Z7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/434131:NRI_RS00530 ^@ http://purl.uniprot.org/uniprot/C6V407 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/434131:NRI_RS00260 ^@ http://purl.uniprot.org/uniprot/C6V3U2 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/434131:NRI_RS03980 ^@ http://purl.uniprot.org/uniprot/C6V665 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/434131:NRI_RS01325 ^@ http://purl.uniprot.org/uniprot/C6V4H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS01310 ^@ http://purl.uniprot.org/uniprot/C6V4G8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/434131:NRI_RS03245 ^@ http://purl.uniprot.org/uniprot/C6V5Q3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/434131:NRI_RS01120 ^@ http://purl.uniprot.org/uniprot/C6V4D0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/434131:NRI_RS00990 ^@ http://purl.uniprot.org/uniprot/C6V4A6 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/434131:NRI_RS02070 ^@ http://purl.uniprot.org/uniprot/C6V4Y8 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/434131:NRI_RS00875 ^@ http://purl.uniprot.org/uniprot/C6V480 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/434131:NRI_RS00130 ^@ http://purl.uniprot.org/uniprot/C6V3R5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/434131:NRI_RS02790 ^@ http://purl.uniprot.org/uniprot/C6V5F5 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/434131:NRI_RS03940 ^@ http://purl.uniprot.org/uniprot/C6V654 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/434131:NRI_RS01565 ^@ http://purl.uniprot.org/uniprot/C6V4M5 ^@ Cofactor|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Binds 1 FMN per subunit. http://togogenome.org/gene/434131:NRI_RS03375 ^@ http://purl.uniprot.org/uniprot/C6V5T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/434131:NRI_RS01865 ^@ http://purl.uniprot.org/uniprot/C6V4U4 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.