http://togogenome.org/gene/55661:CLCN4 ^@ http://purl.uniprot.org/uniprot/A0A091FTG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/55661:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A091FX10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/55661:CLDN20 ^@ http://purl.uniprot.org/uniprot/A0A091FP58 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/55661:MAPK6 ^@ http://purl.uniprot.org/uniprot/A0A091FT94 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/55661:EPYC ^@ http://purl.uniprot.org/uniprot/A0A091G2C6 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/55661:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A091G608 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/55661:LOC104058165 ^@ http://purl.uniprot.org/uniprot/A0A091G1D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/55661:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A091FS88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/55661:GNB3 ^@ http://purl.uniprot.org/uniprot/A0A091GDL1 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/55661:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/A0A091GVT4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/55661:CEP76 ^@ http://purl.uniprot.org/uniprot/A0A091GGB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/55661:SLC25A10 ^@ http://purl.uniprot.org/uniprot/A0A091FZV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/55661:STX7 ^@ http://purl.uniprot.org/uniprot/A0A091FZX0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/55661:AVPR1B ^@ http://purl.uniprot.org/uniprot/A0A091GWB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:LOC104056762 ^@ http://purl.uniprot.org/uniprot/A0A091FY17 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/55661:NID1 ^@ http://purl.uniprot.org/uniprot/A0A091G6Y3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/55661:GJA1 ^@ http://purl.uniprot.org/uniprot/A0A091FFB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/55661:SI ^@ http://purl.uniprot.org/uniprot/A0A091GJ02 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:CLP1 ^@ http://purl.uniprot.org/uniprot/A0A091G980 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/55661:POLR3D ^@ http://purl.uniprot.org/uniprot/A0A091FRD2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:MLH1 ^@ http://purl.uniprot.org/uniprot/A0A091FJK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/55661:LOC104061352 ^@ http://purl.uniprot.org/uniprot/A0A091G7L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/55661:DNAAF4 ^@ http://purl.uniprot.org/uniprot/A0A091G7B0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Dynein axonemal particle|||neuron projection http://togogenome.org/gene/55661:RPL27 ^@ http://purl.uniprot.org/uniprot/A0A091FSF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/55661:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A091GDS2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/55661:SLC39A3 ^@ http://purl.uniprot.org/uniprot/A0A091H5Q2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/55661:UTP23 ^@ http://purl.uniprot.org/uniprot/A0A091FM14 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/55661:CLRN1 ^@ http://purl.uniprot.org/uniprot/A0A091H4F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/55661:ISCA1 ^@ http://purl.uniprot.org/uniprot/A0A091G454 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/55661:AIDA ^@ http://purl.uniprot.org/uniprot/A0A091GN59 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/55661:BRINP1 ^@ http://purl.uniprot.org/uniprot/A0A091H834 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/55661:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A091FUD0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/55661:FN3K ^@ http://purl.uniprot.org/uniprot/A0A091G384 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/55661:MB ^@ http://purl.uniprot.org/uniprot/A0A091H5V9 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/55661:ASF1A ^@ http://purl.uniprot.org/uniprot/A0A091G7M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/55661:KIN ^@ http://purl.uniprot.org/uniprot/A0A091G8J5 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/55661:SERPINF1 ^@ http://purl.uniprot.org/uniprot/A0A091G109 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/55661:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A091FJS5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/55661:CALHM1 ^@ http://purl.uniprot.org/uniprot/A0A091FIS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/55661:SFRP2 ^@ http://purl.uniprot.org/uniprot/A0A091G879 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:KHDRBS3 ^@ http://purl.uniprot.org/uniprot/A0A091G0P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KHDRBS family.|||Cytoplasm http://togogenome.org/gene/55661:LOC104068952 ^@ http://purl.uniprot.org/uniprot/A0A091FRR3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/55661:CLRN3 ^@ http://purl.uniprot.org/uniprot/A0A091G806 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/55661:DLGAP1 ^@ http://purl.uniprot.org/uniprot/A0A091GG85 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/55661:BDNF ^@ http://purl.uniprot.org/uniprot/A0A091FT70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.|||Secreted http://togogenome.org/gene/55661:PTGS2 ^@ http://purl.uniprot.org/uniprot/A0A091GDT9 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:RUNX3 ^@ http://purl.uniprot.org/uniprot/A0A091GA44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:C3H6orf120 ^@ http://purl.uniprot.org/uniprot/A0A091H383 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||Secreted http://togogenome.org/gene/55661:LOC104065657 ^@ http://purl.uniprot.org/uniprot/A0A091GHR0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/55661:NUDT12 ^@ http://purl.uniprot.org/uniprot/A0A091GMT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/55661:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A091GBD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/55661:LOC104054910 ^@ http://purl.uniprot.org/uniprot/A0A091FSA6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/55661:MED13 ^@ http://purl.uniprot.org/uniprot/A0A091H3Q0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/55661:BCL2A1 ^@ http://purl.uniprot.org/uniprot/A0A091G4B2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/55661:IFT56 ^@ http://purl.uniprot.org/uniprot/A0A091FVK0 ^@ Similarity ^@ Belongs to the IFT56 family. http://togogenome.org/gene/55661:ST8SIA4 ^@ http://purl.uniprot.org/uniprot/A0A091G2T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/55661:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/A0A091FXU5 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/55661:LOC104061435 ^@ http://purl.uniprot.org/uniprot/A0A091G9G5 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/55661:PRPH2 ^@ http://purl.uniprot.org/uniprot/A0A091GLV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/55661:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A091GKH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/55661:ATF7IP ^@ http://purl.uniprot.org/uniprot/A0A091FTQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/55661:CLDN2 ^@ http://purl.uniprot.org/uniprot/A0A091FQQ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/55661:HSPA4L ^@ http://purl.uniprot.org/uniprot/A0A091GFD1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/55661:SLC34A2 ^@ http://purl.uniprot.org/uniprot/A0A091GZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:RAG1 ^@ http://purl.uniprot.org/uniprot/A0A091FX46 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/55661:SAP18 ^@ http://purl.uniprot.org/uniprot/A0A091GFH7 ^@ Function|||Similarity ^@ Belongs to the SAP18 family.|||Involved in the tethering of the SIN3 complex to core histone proteins. http://togogenome.org/gene/55661:TNFSF13B ^@ http://purl.uniprot.org/uniprot/A0A091GBJ6 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/55661:HDLBP ^@ http://purl.uniprot.org/uniprot/A0A091GFQ7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/55661:GNL2 ^@ http://purl.uniprot.org/uniprot/A0A091GCB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/55661:METTL16 ^@ http://purl.uniprot.org/uniprot/A0A091GGU6 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. http://togogenome.org/gene/55661:UNC93A ^@ http://purl.uniprot.org/uniprot/A0A091FTJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/55661:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A091GH21 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/55661:CRY1 ^@ http://purl.uniprot.org/uniprot/A0A091FX31 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/55661:TFIP11 ^@ http://purl.uniprot.org/uniprot/A0A091G3P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFP11/STIP family.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.|||Nucleus http://togogenome.org/gene/55661:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/A0A091FQL8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/55661:GGNBP2 ^@ http://purl.uniprot.org/uniprot/A0A091GG46 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/55661:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A091GRD6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:TLX1 ^@ http://purl.uniprot.org/uniprot/A0A091G244 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:SPC25 ^@ http://purl.uniprot.org/uniprot/A0A091FNY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/55661:ALDOB ^@ http://purl.uniprot.org/uniprot/A0A091GHX0 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/55661:UBE4A ^@ http://purl.uniprot.org/uniprot/A0A091FFQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/55661:CDPF1 ^@ http://purl.uniprot.org/uniprot/A0A091GCU3 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/55661:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A091FTS7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/55661:CDX1 ^@ http://purl.uniprot.org/uniprot/A0A091FLB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/55661:NDP ^@ http://purl.uniprot.org/uniprot/A0A091G4A0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/55661:MMP23B ^@ http://purl.uniprot.org/uniprot/A0A091FRI9 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:SCG2 ^@ http://purl.uniprot.org/uniprot/A0A091GNU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/55661:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A091FLF6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/55661:TPI1 ^@ http://purl.uniprot.org/uniprot/A0A091GH11 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/55661:TH ^@ http://purl.uniprot.org/uniprot/A0A091FQK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region http://togogenome.org/gene/55661:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A091FJG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/55661:GRPR ^@ http://purl.uniprot.org/uniprot/A0A091GE65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:HCRTR2 ^@ http://purl.uniprot.org/uniprot/A0A091GH07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:FGF6 ^@ http://purl.uniprot.org/uniprot/A0A091H7V5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/55661:CDK7 ^@ http://purl.uniprot.org/uniprot/A0A091GCQ4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/55661:RPLP1 ^@ http://purl.uniprot.org/uniprot/A0A091GFX3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/55661:CORT ^@ http://purl.uniprot.org/uniprot/A0A091G7Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/55661:GDPD2 ^@ http://purl.uniprot.org/uniprot/A0A091FIG9 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/55661:CCNL2 ^@ http://purl.uniprot.org/uniprot/A0A091FVU9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/55661:TRAPPC11 ^@ http://purl.uniprot.org/uniprot/A0A091GCM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPPC11 family.|||Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.|||cis-Golgi network http://togogenome.org/gene/55661:MOGAT2 ^@ http://purl.uniprot.org/uniprot/A0A091GGJ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:ACTR10 ^@ http://purl.uniprot.org/uniprot/A0A091FVS9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/55661:YAF2 ^@ http://purl.uniprot.org/uniprot/A0A091GBX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:LOC104056241 ^@ http://purl.uniprot.org/uniprot/A0A091FWZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/55661:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/A0A091GH91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/55661:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A091FMI8 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/55661:CHRM2 ^@ http://purl.uniprot.org/uniprot/A0A091G495 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/55661:GMPR ^@ http://purl.uniprot.org/uniprot/A0A091G9F3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/55661:ASIC4 ^@ http://purl.uniprot.org/uniprot/A0A091FNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/55661:IFNG ^@ http://purl.uniprot.org/uniprot/A0A091FLR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.|||Secreted http://togogenome.org/gene/55661:SPRING1 ^@ http://purl.uniprot.org/uniprot/A0A091FWR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/55661:LOC104064687 ^@ http://purl.uniprot.org/uniprot/A0A091GEC8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/55661:EPB41 ^@ http://purl.uniprot.org/uniprot/A0A091G5F5 ^@ Subcellular Location Annotation ^@ Nucleus|||cell cortex|||cytoskeleton http://togogenome.org/gene/55661:TDO2 ^@ http://purl.uniprot.org/uniprot/A0A091GEG2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:RFTN2 ^@ http://purl.uniprot.org/uniprot/A0A091GJC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:FSHB ^@ http://purl.uniprot.org/uniprot/A0A091GFP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/55661:TINAG ^@ http://purl.uniprot.org/uniprot/A0A091GFU1 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/55661:ACTG2 ^@ http://purl.uniprot.org/uniprot/A0A091FNA0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/55661:WLS ^@ http://purl.uniprot.org/uniprot/A0A091GLU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/55661:NR2E3 ^@ http://purl.uniprot.org/uniprot/A0A091GI68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/55661:HSPB7 ^@ http://purl.uniprot.org/uniprot/A0A091FQA0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/55661:NOX3 ^@ http://purl.uniprot.org/uniprot/A0A091FNQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/55661:CPB1 ^@ http://purl.uniprot.org/uniprot/A0A091GE76 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/55661:ITM2B ^@ http://purl.uniprot.org/uniprot/A0A091G232 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/55661:EEF1B2 ^@ http://purl.uniprot.org/uniprot/A0A091G2L2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/55661:MAB21L2 ^@ http://purl.uniprot.org/uniprot/A0A091G1T6 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/55661:TPH1 ^@ http://purl.uniprot.org/uniprot/A0A091FN07 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/55661:RTF2 ^@ http://purl.uniprot.org/uniprot/A0A091FVI8 ^@ Similarity ^@ Belongs to the rtf2 family. http://togogenome.org/gene/55661:CENPN ^@ http://purl.uniprot.org/uniprot/A0A091GQ60 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/55661:LOC104067255 ^@ http://purl.uniprot.org/uniprot/A0A091H9D6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/55661:SEMA6A ^@ http://purl.uniprot.org/uniprot/A0A091G6V5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:FTCD ^@ http://purl.uniprot.org/uniprot/A0A091H2Q8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds and promotes bundling of vimentin filaments originating from the Golgi.|||Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.|||Golgi apparatus|||Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.|||In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.|||In the N-terminal section; belongs to the formiminotransferase family.|||centriole http://togogenome.org/gene/55661:NEUROD6 ^@ http://purl.uniprot.org/uniprot/A0A091GHE6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A091FKV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/55661:SLC26A9 ^@ http://purl.uniprot.org/uniprot/A0A091G7P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.|||Membrane http://togogenome.org/gene/55661:MOS ^@ http://purl.uniprot.org/uniprot/A0A091FML3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/55661:MAT1A ^@ http://purl.uniprot.org/uniprot/A0A091GAH2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/55661:AMD1 ^@ http://purl.uniprot.org/uniprot/A0A091GY92 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. http://togogenome.org/gene/55661:BARX2 ^@ http://purl.uniprot.org/uniprot/A0A091GIU5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:CD9 ^@ http://purl.uniprot.org/uniprot/A0A091GM00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/55661:EPHB6 ^@ http://purl.uniprot.org/uniprot/A0A091GGG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/55661:TMEM230 ^@ http://purl.uniprot.org/uniprot/A0A091FIT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/55661:MED27 ^@ http://purl.uniprot.org/uniprot/A0A091GMD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 27 family.|||Nucleus http://togogenome.org/gene/55661:MAS1 ^@ http://purl.uniprot.org/uniprot/A0A091GI78 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/55661:GABRA4 ^@ http://purl.uniprot.org/uniprot/A0A091FZ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/55661:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A091GA58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/55661:SULT1C4 ^@ http://purl.uniprot.org/uniprot/A0A091FXQ6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/55661:CAV3 ^@ http://purl.uniprot.org/uniprot/A0A091GD03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/55661:TYMS ^@ http://purl.uniprot.org/uniprot/A0A091GBK7 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/55661:MYF6 ^@ http://purl.uniprot.org/uniprot/A0A091G8W9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:SGCG ^@ http://purl.uniprot.org/uniprot/A0A091GGP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/55661:TMEM35A ^@ http://purl.uniprot.org/uniprot/A0A091GCR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/55661:LOC104064097 ^@ http://purl.uniprot.org/uniprot/A0A091GFX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:LOC104066672 ^@ http://purl.uniprot.org/uniprot/A0A091FJ37 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/55661:MYADML2 ^@ http://purl.uniprot.org/uniprot/A0A091FW00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/55661:NAT10 ^@ http://purl.uniprot.org/uniprot/A0A091FI08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with THUMPD1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/55661:CDC20 ^@ http://purl.uniprot.org/uniprot/A0A091FYF8 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/55661:WNT7A ^@ http://purl.uniprot.org/uniprot/A0A091GE75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/55661:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A091FSH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/55661:FAM110B ^@ http://purl.uniprot.org/uniprot/A0A091G6D9 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/55661:ANKH ^@ http://purl.uniprot.org/uniprot/A0A091FM73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/55661:LOC104057226 ^@ http://purl.uniprot.org/uniprot/A0A091FV88 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/55661:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/A0A091FP41 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/55661:CKMT2 ^@ http://purl.uniprot.org/uniprot/A0A091G3K1 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/55661:GLUL ^@ http://purl.uniprot.org/uniprot/A0A091G1C5 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/55661:ATOH7 ^@ http://purl.uniprot.org/uniprot/A0A091GHT1 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/55661:MMP2 ^@ http://purl.uniprot.org/uniprot/A0A091FU85 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/55661:AK5 ^@ http://purl.uniprot.org/uniprot/A0A091FYF0 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/55661:LOC104067415 ^@ http://purl.uniprot.org/uniprot/A0A091G8T4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/55661:NUDC ^@ http://purl.uniprot.org/uniprot/A0A091GHR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudC family.|||Midbody|||spindle http://togogenome.org/gene/55661:OVOL2 ^@ http://purl.uniprot.org/uniprot/A0A091G4V1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:SSRP1 ^@ http://purl.uniprot.org/uniprot/A0A091G976 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/55661:SENP8 ^@ http://purl.uniprot.org/uniprot/A0A091GGM7 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/55661:TAGLN3 ^@ http://purl.uniprot.org/uniprot/A0A091GH12 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/55661:RPS3A ^@ http://purl.uniprot.org/uniprot/A0A091FLB4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).|||Cytoplasm|||nucleolus http://togogenome.org/gene/55661:AHSA1 ^@ http://purl.uniprot.org/uniprot/A0A091GEY6 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/55661:CLDN11 ^@ http://purl.uniprot.org/uniprot/A0A091FI71 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/55661:TALDO1 ^@ http://purl.uniprot.org/uniprot/A0A091GGN1 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/55661:LOC104068094 ^@ http://purl.uniprot.org/uniprot/A0A091FNL0 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/55661:LOC104068682 ^@ http://purl.uniprot.org/uniprot/A0A091FMD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/55661:SLC41A2 ^@ http://purl.uniprot.org/uniprot/A0A091G6K8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/55661:CCNK ^@ http://purl.uniprot.org/uniprot/A0A091GLB7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/55661:CACNG2 ^@ http://purl.uniprot.org/uniprot/A0A091H5W5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/55661:CRYAA ^@ http://purl.uniprot.org/uniprot/A0A091G0Y2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/55661:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/A0A091FSW4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:CRMP1 ^@ http://purl.uniprot.org/uniprot/A0A091GAG7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/55661:TMEM30A ^@ http://purl.uniprot.org/uniprot/A0A091GCY4 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/55661:NDUFS8 ^@ http://purl.uniprot.org/uniprot/A0A091H2F9 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/55661:KCNK5 ^@ http://purl.uniprot.org/uniprot/A0A091G8I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/55661:JUN ^@ http://purl.uniprot.org/uniprot/A0A091GJT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/55661:LYN ^@ http://purl.uniprot.org/uniprot/A0A091FK40 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/55661:EMP1 ^@ http://purl.uniprot.org/uniprot/A0A091FVJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/55661:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A091G4X0 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/55661:PPP1R1C ^@ http://purl.uniprot.org/uniprot/A0A091GDU4 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/55661:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A091FUM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/55661:TMEM47 ^@ http://purl.uniprot.org/uniprot/A0A091FJH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/55661:HOXA11 ^@ http://purl.uniprot.org/uniprot/A0A091G0R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/55661:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A091GQD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/55661:S100Z ^@ http://purl.uniprot.org/uniprot/A0A091FVS1 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/55661:ANXA1 ^@ http://purl.uniprot.org/uniprot/A0A091G7J8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasm|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium http://togogenome.org/gene/55661:LOC104058755 ^@ http://purl.uniprot.org/uniprot/A0A091FH35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/55661:ZNF706 ^@ http://purl.uniprot.org/uniprot/A0A091FU19 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/55661:RIC8A ^@ http://purl.uniprot.org/uniprot/A0A091FXR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/55661:CALHM2 ^@ http://purl.uniprot.org/uniprot/A0A091FK43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/55661:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/A0A091G938 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/55661:TFAP2D ^@ http://purl.uniprot.org/uniprot/A0A091FPE9 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/55661:IL7R ^@ http://purl.uniprot.org/uniprot/A0A091GC95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane http://togogenome.org/gene/55661:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A091FK63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/55661:HOXB9 ^@ http://purl.uniprot.org/uniprot/A0A091FP05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/55661:CRYBB1 ^@ http://purl.uniprot.org/uniprot/A0A091G1X1 ^@ Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/55661:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A091G320 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/55661:CDKN1B ^@ http://purl.uniprot.org/uniprot/A0A091H7T4 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/55661:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A091GGH7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:F2 ^@ http://purl.uniprot.org/uniprot/A0A091GNY2 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/55661:SS18L2 ^@ http://purl.uniprot.org/uniprot/A0A091GJ54 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/55661:USP35 ^@ http://purl.uniprot.org/uniprot/A0A091GGN7 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/55661:MC4R ^@ http://purl.uniprot.org/uniprot/A0A091FN23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/55661:SYNGR3 ^@ http://purl.uniprot.org/uniprot/A0A091GSK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/55661:AQP1 ^@ http://purl.uniprot.org/uniprot/A0A091FX60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/55661:VPS26B ^@ http://purl.uniprot.org/uniprot/A0A091GIV3 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/55661:OTC ^@ http://purl.uniprot.org/uniprot/A0A091FGQ7 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/55661:RHO ^@ http://purl.uniprot.org/uniprot/A0A091GD08 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/55661:KIFBP ^@ http://purl.uniprot.org/uniprot/A0A091GAL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KIF-binding protein family.|||cytoskeleton http://togogenome.org/gene/55661:WNT7B ^@ http://purl.uniprot.org/uniprot/A0A091GB14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/55661:CYGB ^@ http://purl.uniprot.org/uniprot/A0A091GBV6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/55661:LOC104065331 ^@ http://purl.uniprot.org/uniprot/A0A091GFV5 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/55661:HOXA6 ^@ http://purl.uniprot.org/uniprot/A0A091G401 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/55661:GPN3 ^@ http://purl.uniprot.org/uniprot/A0A091GC82 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/55661:WSCD1 ^@ http://purl.uniprot.org/uniprot/A0A091FVF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Golgi apparatus membrane|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/55661:APOD ^@ http://purl.uniprot.org/uniprot/A0A091GCF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/55661:LHFPL2 ^@ http://purl.uniprot.org/uniprot/A0A091GG32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/55661:BDKRB2 ^@ http://purl.uniprot.org/uniprot/A0A091G0P7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/55661:LOC104063758 ^@ http://purl.uniprot.org/uniprot/A0A091GF16 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/55661:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A091GAW8 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/55661:LOC104066913 ^@ http://purl.uniprot.org/uniprot/A0A091FI95 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/55661:LOC104067546 ^@ http://purl.uniprot.org/uniprot/A0A091FNM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/55661:LOC104067090 ^@ http://purl.uniprot.org/uniprot/A0A091GJZ2 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/55661:SCN3B ^@ http://purl.uniprot.org/uniprot/A0A091FT20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/55661:EPHA7 ^@ http://purl.uniprot.org/uniprot/A0A091FKZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/55661:MALL ^@ http://purl.uniprot.org/uniprot/A0A091G4U8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/55661:YIPF1 ^@ http://purl.uniprot.org/uniprot/A0A091G3V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/55661:GAB3 ^@ http://purl.uniprot.org/uniprot/A0A091G7C1 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/55661:COG2 ^@ http://purl.uniprot.org/uniprot/A0A091GED9 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/55661:CDC34 ^@ http://purl.uniprot.org/uniprot/A0A091FPI9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/55661:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A091GEI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/55661:CPLX4 ^@ http://purl.uniprot.org/uniprot/A0A091G9F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/55661:MEOX2 ^@ http://purl.uniprot.org/uniprot/A0A091FPK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:NSUN6 ^@ http://purl.uniprot.org/uniprot/A0A091G128 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/55661:LOC104059960 ^@ http://purl.uniprot.org/uniprot/A0A091GRM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/55661:MET ^@ http://purl.uniprot.org/uniprot/A0A091GDH7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/55661:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A091FYW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/55661:GPR6 ^@ http://purl.uniprot.org/uniprot/A0A091GYA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:TADA2A ^@ http://purl.uniprot.org/uniprot/A0A091H3R2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:TIMM10 ^@ http://purl.uniprot.org/uniprot/A0A091G810 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/55661:TJP2 ^@ http://purl.uniprot.org/uniprot/A0A091GE62 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/55661:BMP5 ^@ http://purl.uniprot.org/uniprot/A0A091GJ85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/55661:FERMT2 ^@ http://purl.uniprot.org/uniprot/A0A091FZI0 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/55661:NKX2-5 ^@ http://purl.uniprot.org/uniprot/A0A091GHI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:LOC104066411 ^@ http://purl.uniprot.org/uniprot/A0A091GIE2 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/55661:ARSI ^@ http://purl.uniprot.org/uniprot/A0A091FLY9 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/55661:DPH3 ^@ http://purl.uniprot.org/uniprot/A0A091GPN8 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/55661:RPL6 ^@ http://purl.uniprot.org/uniprot/A0A091G1U5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/55661:MRAP2 ^@ http://purl.uniprot.org/uniprot/A0A091GCH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/55661:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/A0A091FP60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/55661:PTP4A1 ^@ http://purl.uniprot.org/uniprot/A0A091FMP4 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/55661:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A091FKQ6 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/55661:PIGO ^@ http://purl.uniprot.org/uniprot/A0A091FXK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/55661:XKR9 ^@ http://purl.uniprot.org/uniprot/A0A091FPS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/55661:LOC104067122 ^@ http://purl.uniprot.org/uniprot/A0A091H904 ^@ Similarity ^@ Belongs to the TFIIE alpha subunit family. http://togogenome.org/gene/55661:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/A0A091GJ09 ^@ Caution|||Function|||Subunit ^@ Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:TPM4 ^@ http://purl.uniprot.org/uniprot/A0A091G8T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/55661:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A091G753 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/55661:GDF5 ^@ http://purl.uniprot.org/uniprot/A0A091GDR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/55661:LOC104055778 ^@ http://purl.uniprot.org/uniprot/A0A091FVN4 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/55661:LOC104057265 ^@ http://purl.uniprot.org/uniprot/A0A091FXS9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/55661:HOXD4 ^@ http://purl.uniprot.org/uniprot/A0A091GDP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/55661:DIABLO ^@ http://purl.uniprot.org/uniprot/A0A091G046 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/55661:GNG2 ^@ http://purl.uniprot.org/uniprot/A0A091G022 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/55661:NDST1 ^@ http://purl.uniprot.org/uniprot/A0A091FHA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/55661:MSTN ^@ http://purl.uniprot.org/uniprot/A0A091GMQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/55661:LOC104055104 ^@ http://purl.uniprot.org/uniprot/A0A091FU68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Cytoplasm http://togogenome.org/gene/55661:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A091FJD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/55661:INS ^@ http://purl.uniprot.org/uniprot/A0A091FRU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/55661:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A091GA53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/55661:LOC104059959 ^@ http://purl.uniprot.org/uniprot/A0A091G609 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/55661:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/A0A091FY86 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/55661:LOC104061436 ^@ http://purl.uniprot.org/uniprot/A0A091GV45 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/55661:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A091FX64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/55661:IAPP ^@ http://purl.uniprot.org/uniprot/A0A091GJH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcitonin family.|||Secreted http://togogenome.org/gene/55661:SLC24A1 ^@ http://purl.uniprot.org/uniprot/A0A091GIT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/55661:FUCA1 ^@ http://purl.uniprot.org/uniprot/A0A091GRY0 ^@ Function|||Similarity ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family. http://togogenome.org/gene/55661:SLC5A7 ^@ http://purl.uniprot.org/uniprot/A0A091FTV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/55661:PPARGC1A ^@ http://purl.uniprot.org/uniprot/A0A091GAY6 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/55661:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A091FW17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/55661:RBM15B ^@ http://purl.uniprot.org/uniprot/A0A091GPE6 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/55661:MED24 ^@ http://purl.uniprot.org/uniprot/A0A091FFJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/55661:ACSL5 ^@ http://purl.uniprot.org/uniprot/A0A091FMT8 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/55661:VPS18 ^@ http://purl.uniprot.org/uniprot/A0A091H9G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/55661:BRS3 ^@ http://purl.uniprot.org/uniprot/A0A091G4S8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with C6orf89.|||Membrane http://togogenome.org/gene/55661:LOC104059369 ^@ http://purl.uniprot.org/uniprot/A0A091FLX7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/55661:PCMTD2 ^@ http://purl.uniprot.org/uniprot/A0A091G6F0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/55661:HIGD1A ^@ http://purl.uniprot.org/uniprot/A0A091GJ89 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/55661:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A091FSL3 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/55661:PTH ^@ http://purl.uniprot.org/uniprot/A0A091GAJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.|||Secreted http://togogenome.org/gene/55661:AQP3 ^@ http://purl.uniprot.org/uniprot/A0A091GGW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:GEM ^@ http://purl.uniprot.org/uniprot/A0A091FXZ5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/55661:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A091FVE2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/55661:PDE6B ^@ http://purl.uniprot.org/uniprot/A0A091GCU6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/55661:EMX2 ^@ http://purl.uniprot.org/uniprot/A0A091G9R4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:LOC104065332 ^@ http://purl.uniprot.org/uniprot/A0A091H4Q2 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/55661:CDH19 ^@ http://purl.uniprot.org/uniprot/A0A091FSL4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/55661:SQLE ^@ http://purl.uniprot.org/uniprot/A0A091G309 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/55661:KDELR3 ^@ http://purl.uniprot.org/uniprot/A0A091GKL0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/55661:ATP23 ^@ http://purl.uniprot.org/uniprot/A0A091GH40 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/55661:alpha-D ^@ http://purl.uniprot.org/uniprot/Q7ZT86 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/55661:FUCA2 ^@ http://purl.uniprot.org/uniprot/A0A091FLG4 ^@ Function|||Similarity ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family. http://togogenome.org/gene/55661:SNX14 ^@ http://purl.uniprot.org/uniprot/A0A091G9K4 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/55661:ATP5F1E ^@ http://purl.uniprot.org/uniprot/A0A091FJQ8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/55661:LOC104060175 ^@ http://purl.uniprot.org/uniprot/A0A091G6J4 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/55661:ELOVL5 ^@ http://purl.uniprot.org/uniprot/A0A091GIU1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||dendrite http://togogenome.org/gene/55661:CLDN14 ^@ http://purl.uniprot.org/uniprot/A0A091GEH7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/55661:PCK1 ^@ http://purl.uniprot.org/uniprot/A0A091FI99 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/55661:CRYBA4 ^@ http://purl.uniprot.org/uniprot/A0A091G463 ^@ Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/55661:VEPH1 ^@ http://purl.uniprot.org/uniprot/A0A091FY99 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/55661:KLHL15 ^@ http://purl.uniprot.org/uniprot/A0A091GQA0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:RBM22 ^@ http://purl.uniprot.org/uniprot/A0A091G6Z1 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/55661:CCND1 ^@ http://purl.uniprot.org/uniprot/A0A091FHZ1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/55661:SLC13A4 ^@ http://purl.uniprot.org/uniprot/A0A091GP96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/55661:TAT ^@ http://purl.uniprot.org/uniprot/A0A091G9N3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/55661:LOC104055596 ^@ http://purl.uniprot.org/uniprot/A0A091FRI1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/55661:GYS2 ^@ http://purl.uniprot.org/uniprot/A0A091FNL4 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/55661:NMUR2 ^@ http://purl.uniprot.org/uniprot/A0A091FLD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/55661:FEN1 ^@ http://purl.uniprot.org/uniprot/A0A091GDP3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Mitochondrion|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/55661:SNF8 ^@ http://purl.uniprot.org/uniprot/A0A091FQV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/55661:DYM ^@ http://purl.uniprot.org/uniprot/A0A091GEM7 ^@ Similarity ^@ Belongs to the dymeclin family. http://togogenome.org/gene/55661:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A091FP98 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/55661:FAM135B ^@ http://purl.uniprot.org/uniprot/A0A091GCF7 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/55661:RHCE ^@ http://purl.uniprot.org/uniprot/A0A091G7X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/55661:DUS4L ^@ http://purl.uniprot.org/uniprot/A0A091FSM8 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/55661:GNAL ^@ http://purl.uniprot.org/uniprot/A0A091GGA6 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/55661:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A091GHC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/55661:AARS2 ^@ http://purl.uniprot.org/uniprot/A0A091FJP6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/55661:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A091FSW0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:IL12B ^@ http://purl.uniprot.org/uniprot/A0A091GD15 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-12B family.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/55661:QRFP ^@ http://purl.uniprot.org/uniprot/A0A091GJB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RFamide neuropeptide family.|||Secreted http://togogenome.org/gene/55661:NSG2 ^@ http://purl.uniprot.org/uniprot/A0A091GHI6 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/55661:PTPN4 ^@ http://purl.uniprot.org/uniprot/A0A091G9L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/55661:LOC104055955 ^@ http://purl.uniprot.org/uniprot/A0A091FGA7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/55661:PYGB ^@ http://purl.uniprot.org/uniprot/A0A091GTE7 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/55661:LOC104057257 ^@ http://purl.uniprot.org/uniprot/A0A091FZ48 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/55661:GPX7 ^@ http://purl.uniprot.org/uniprot/A0A091G4S0 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/55661:CRYAB ^@ http://purl.uniprot.org/uniprot/A0A091GNL6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/55661:CACNG1 ^@ http://purl.uniprot.org/uniprot/A0A091GB72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/55661:HTR2A ^@ http://purl.uniprot.org/uniprot/A0A091GI95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/55661:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A091FJT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/55661:GDF9 ^@ http://purl.uniprot.org/uniprot/A0A091FK85 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/55661:CA7 ^@ http://purl.uniprot.org/uniprot/A0A091GG48 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/55661:PHGDH ^@ http://purl.uniprot.org/uniprot/A0A091GZN1 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/55661:GAB1 ^@ http://purl.uniprot.org/uniprot/A0A091FJK1 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/55661:BOK ^@ http://purl.uniprot.org/uniprot/A0A091GIN5 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/55661:DMBX1 ^@ http://purl.uniprot.org/uniprot/A0A091G709 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:NDUFB6 ^@ http://purl.uniprot.org/uniprot/A0A091FQL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/55661:TRADD ^@ http://purl.uniprot.org/uniprot/A0A091FSA8 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/55661:EXOSC2 ^@ http://purl.uniprot.org/uniprot/A0A091GKF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/55661:HSPB1 ^@ http://purl.uniprot.org/uniprot/A0A091FZI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||spindle http://togogenome.org/gene/55661:SPARC ^@ http://purl.uniprot.org/uniprot/A0A091FHB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/55661:MAPK8 ^@ http://purl.uniprot.org/uniprot/A0A091FPX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/55661:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A091FUG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/55661:GPHB5 ^@ http://purl.uniprot.org/uniprot/A0A091GC96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/55661:TARDBP ^@ http://purl.uniprot.org/uniprot/A0A091GT35 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:SNX20 ^@ http://purl.uniprot.org/uniprot/A0A091FR36 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Membrane http://togogenome.org/gene/55661:ANXA8L1 ^@ http://purl.uniprot.org/uniprot/A0A091FPY8 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/55661:TMEM170B ^@ http://purl.uniprot.org/uniprot/A0A091G9D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/55661:SPTSSA ^@ http://purl.uniprot.org/uniprot/A0A091GVP6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/55661:HSPA2 ^@ http://purl.uniprot.org/uniprot/A0A091GA19 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/55661:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A091GHM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/55661:FABP7 ^@ http://purl.uniprot.org/uniprot/A0A091FWM5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/55661:DDO ^@ http://purl.uniprot.org/uniprot/A0A091GAV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/55661:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A091G991 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/55661:NIP7 ^@ http://purl.uniprot.org/uniprot/A0A091FSJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/55661:SEH1L ^@ http://purl.uniprot.org/uniprot/A0A091GHH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/55661:GDNF ^@ http://purl.uniprot.org/uniprot/A0A091G5Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/55661:ADORA2B ^@ http://purl.uniprot.org/uniprot/A0A091FYY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/55661:STAC ^@ http://purl.uniprot.org/uniprot/A0A091FV43 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/55661:FAM199X ^@ http://purl.uniprot.org/uniprot/A0A091GCS0 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/55661:TIPIN ^@ http://purl.uniprot.org/uniprot/A0A091GIT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/55661:LOC104057273 ^@ http://purl.uniprot.org/uniprot/A0A091FXS9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/55661:ADA2 ^@ http://purl.uniprot.org/uniprot/A0A091FWC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/55661:VEGFD ^@ http://purl.uniprot.org/uniprot/A0A091GB91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/55661:ITPA ^@ http://purl.uniprot.org/uniprot/A0A091GMT1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/55661:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/A0A091GGK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/55661:MAB21L1 ^@ http://purl.uniprot.org/uniprot/A0A091GHR2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/55661:CDKL1 ^@ http://purl.uniprot.org/uniprot/A0A091FVN6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/55661:ATP6V1F ^@ http://purl.uniprot.org/uniprot/A0A091G9X0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/55661:MYMK ^@ http://purl.uniprot.org/uniprot/A0A091GMU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:NPY1R ^@ http://purl.uniprot.org/uniprot/A0A091GBL4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/55661:LOC104060074 ^@ http://purl.uniprot.org/uniprot/A0A091G6V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/55661:ENOPH1 ^@ http://purl.uniprot.org/uniprot/A0A091G6S1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/55661:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A091FS22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/55661:POLR2D ^@ http://purl.uniprot.org/uniprot/A0A091H798 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/55661:PPP2CB ^@ http://purl.uniprot.org/uniprot/A0A091GDJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/55661:NUMB ^@ http://purl.uniprot.org/uniprot/A0A091G7F8 ^@ Function ^@ Plays a role in the process of neurogenesis. http://togogenome.org/gene/55661:CRHBP ^@ http://purl.uniprot.org/uniprot/A0A091FX86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/55661:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A091GF94 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/55661:GTF2H2 ^@ http://purl.uniprot.org/uniprot/A0A091G3D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/55661:SERINC1 ^@ http://purl.uniprot.org/uniprot/A0A091FWK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/55661:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/A0A091G0B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/55661:RHCG ^@ http://purl.uniprot.org/uniprot/A0A091G3R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/55661:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A091G7X7 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/55661:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A091GS43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/55661:UBE2R2 ^@ http://purl.uniprot.org/uniprot/A0A091GGE9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/55661:AGPAT3 ^@ http://purl.uniprot.org/uniprot/A0A091G0Y5 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/55661:TRAF5 ^@ http://purl.uniprot.org/uniprot/A0A091GLW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/55661:NPSR1 ^@ http://purl.uniprot.org/uniprot/A0A091GJH3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/55661:ORMDL1 ^@ http://purl.uniprot.org/uniprot/A0A091G2P6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/55661:TAF9B ^@ http://purl.uniprot.org/uniprot/A0A091GCX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/55661:PARK7 ^@ http://purl.uniprot.org/uniprot/A0A091GT06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/55661:HOXB6 ^@ http://purl.uniprot.org/uniprot/A0A091FQU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/55661:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/A0A091GN12 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/55661:MIEF1 ^@ http://purl.uniprot.org/uniprot/A0A091GFZ1 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/55661:NUDT3 ^@ http://purl.uniprot.org/uniprot/A0A091GG21 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/55661:OGN ^@ http://purl.uniprot.org/uniprot/A0A091FXP9 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/55661:LOC104055791 ^@ http://purl.uniprot.org/uniprot/A0A091GGQ2 ^@ Function|||Similarity ^@ Belongs to the apovitellenin family.|||Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes. http://togogenome.org/gene/55661:LOC104057269 ^@ http://purl.uniprot.org/uniprot/A0A091FZ60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/55661:SULT4A1 ^@ http://purl.uniprot.org/uniprot/A0A091G8S5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/55661:KLHL40 ^@ http://purl.uniprot.org/uniprot/A0A091FUI8 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/55661:CAPN15 ^@ http://purl.uniprot.org/uniprot/A0A091GAS6 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/55661:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/A0A091G973 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/55661:GJB1 ^@ http://purl.uniprot.org/uniprot/A0A091GCQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/55661:NDUFA6 ^@ http://purl.uniprot.org/uniprot/A0A091FR94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/55661:TLL1 ^@ http://purl.uniprot.org/uniprot/A0A091GDE0 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:FUT7 ^@ http://purl.uniprot.org/uniprot/A0A091G4F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/55661:LOC104055963 ^@ http://purl.uniprot.org/uniprot/A0A091FL20 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/55661:HSPA14 ^@ http://purl.uniprot.org/uniprot/A0A091FNE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||cytosol http://togogenome.org/gene/55661:POSTN ^@ http://purl.uniprot.org/uniprot/A0A091GHS0 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/55661:VPS54 ^@ http://purl.uniprot.org/uniprot/A0A091FTL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/55661:LOC104059153 ^@ http://purl.uniprot.org/uniprot/A0A091G4I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/55661:SKI ^@ http://purl.uniprot.org/uniprot/A0A091GR93 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/55661:POU1F1 ^@ http://purl.uniprot.org/uniprot/A0A091FSH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/55661:ITGB6 ^@ http://purl.uniprot.org/uniprot/A0A091GDE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:PDE6G ^@ http://purl.uniprot.org/uniprot/A0A091GQG7 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/55661:LOC104067897 ^@ http://purl.uniprot.org/uniprot/A0A091GA17 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/55661:RBP5 ^@ http://purl.uniprot.org/uniprot/A0A091GDK2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/55661:RAB38 ^@ http://purl.uniprot.org/uniprot/A0A091GFX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/55661:FGFBP2 ^@ http://purl.uniprot.org/uniprot/A0A091FJG6 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/55661:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A091FMV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/55661:COPG1 ^@ http://purl.uniprot.org/uniprot/A0A091FFN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/55661:PRL ^@ http://purl.uniprot.org/uniprot/A0A091G8C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/55661:DLX5 ^@ http://purl.uniprot.org/uniprot/A0A091GKI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/55661:LOC104062394 ^@ http://purl.uniprot.org/uniprot/A0A091G8Y8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/55661:CASQ2 ^@ http://purl.uniprot.org/uniprot/A0A091GGT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/55661:INHBA ^@ http://purl.uniprot.org/uniprot/A0A091H673 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/55661:KCNK9 ^@ http://purl.uniprot.org/uniprot/A0A091GDM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane|||pH-dependent, voltage-insensitive, background potassium channel protein. http://togogenome.org/gene/55661:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A091GAT4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||cytoskeleton http://togogenome.org/gene/55661:EHF ^@ http://purl.uniprot.org/uniprot/A0A091FQM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/55661:PSPH ^@ http://purl.uniprot.org/uniprot/A0A091GK59 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/55661:SLC6A6 ^@ http://purl.uniprot.org/uniprot/A0A091GFD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:NUP93 ^@ http://purl.uniprot.org/uniprot/A0A091FSB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/55661:CER1 ^@ http://purl.uniprot.org/uniprot/A0A091FUZ8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/55661:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A091FS30 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/55661:EHD3 ^@ http://purl.uniprot.org/uniprot/A0A091GJU2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/55661:RIOK2 ^@ http://purl.uniprot.org/uniprot/A0A091G5Y6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/55661:KRT222 ^@ http://purl.uniprot.org/uniprot/A0A091FNT5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/55661:SIX1 ^@ http://purl.uniprot.org/uniprot/A0A091G8Q9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:MTERF3 ^@ http://purl.uniprot.org/uniprot/A0A091FXY5 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/55661:RDM1 ^@ http://purl.uniprot.org/uniprot/A0A091GEW4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleolus http://togogenome.org/gene/55661:GNAS ^@ http://purl.uniprot.org/uniprot/A0A091FFH6 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/55661:CCNC ^@ http://purl.uniprot.org/uniprot/A0A091GC04 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/55661:CKS2 ^@ http://purl.uniprot.org/uniprot/A0A091H1L6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/55661:DAO ^@ http://purl.uniprot.org/uniprot/A0A091G080 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/55661:PPM1G ^@ http://purl.uniprot.org/uniprot/A0A091GLK5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/55661:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A091G8Y1 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/55661:HDAC3 ^@ http://purl.uniprot.org/uniprot/A0A091FNC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/55661:EML6 ^@ http://purl.uniprot.org/uniprot/A0A091G4C8 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/55661:HOXA7 ^@ http://purl.uniprot.org/uniprot/A0A091GPL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/55661:PSMA7 ^@ http://purl.uniprot.org/uniprot/A0A091G9J6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/55661:FGF9 ^@ http://purl.uniprot.org/uniprot/A0A091GFH2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/55661:IL2RG ^@ http://purl.uniprot.org/uniprot/A0A091FN82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/55661:UBA3 ^@ http://purl.uniprot.org/uniprot/A0A091G651 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/55661:MRPL12 ^@ http://purl.uniprot.org/uniprot/A0A091GKX4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/55661:HBA2 ^@ http://purl.uniprot.org/uniprot/Q7ZT87 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/55661:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/A0A091FND9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Cytoplasm http://togogenome.org/gene/55661:P2RX5 ^@ http://purl.uniprot.org/uniprot/A0A091FZX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/55661:LOC104060065 ^@ http://purl.uniprot.org/uniprot/A0A091G6T9 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/55661:ORAI2 ^@ http://purl.uniprot.org/uniprot/A0A091GNE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/55661:HOPX ^@ http://purl.uniprot.org/uniprot/A0A091FLC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/55661:TMED2 ^@ http://purl.uniprot.org/uniprot/A0A091FLU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/55661:WASHC1 ^@ http://purl.uniprot.org/uniprot/A0A091FX67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WASH1 family.|||Early endosome membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/55661:TXNL4A ^@ http://purl.uniprot.org/uniprot/A0A091FRU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/55661:TUBB6 ^@ http://purl.uniprot.org/uniprot/A0A091GGA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/55661:DRD1 ^@ http://purl.uniprot.org/uniprot/A0A091GGD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/55661:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A091FQ55 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/55661:LOC104057240 ^@ http://purl.uniprot.org/uniprot/A0A091FGQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/55661:MED30 ^@ http://purl.uniprot.org/uniprot/A0A091GHV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/55661:ZNF622 ^@ http://purl.uniprot.org/uniprot/A0A091FNZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/55661:LOC104065100 ^@ http://purl.uniprot.org/uniprot/A0A091GIM9 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/55661:LOC104059906 ^@ http://purl.uniprot.org/uniprot/A0A091G450 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/55661:CHST1 ^@ http://purl.uniprot.org/uniprot/A0A091GKG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/55661:SNRPE ^@ http://purl.uniprot.org/uniprot/A0A091G6Q9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/55661:PTGR2 ^@ http://purl.uniprot.org/uniprot/A0A091FMG5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/55661:GJA3 ^@ http://purl.uniprot.org/uniprot/A0A091FV75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction