http://togogenome.org/gene/59729:FUNDC1 ^@ http://purl.uniprot.org/uniprot/H0Z6V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/59729:TAF10 ^@ http://purl.uniprot.org/uniprot/B5G075 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Nucleus http://togogenome.org/gene/59729:GPN3 ^@ http://purl.uniprot.org/uniprot/B5FX60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/59729:MED27 ^@ http://purl.uniprot.org/uniprot/B5FXG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 27 family.|||Nucleus http://togogenome.org/gene/59729:ADORA1 ^@ http://purl.uniprot.org/uniprot/H0YT13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/59729:BTBD10 ^@ http://purl.uniprot.org/uniprot/B5FZS3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59729:LEPR ^@ http://purl.uniprot.org/uniprot/H0ZIF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/59729:RPS16 ^@ http://purl.uniprot.org/uniprot/B5FXQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS9 family.|||Nucleus http://togogenome.org/gene/59729:CER1 ^@ http://purl.uniprot.org/uniprot/H0Z2F5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59729:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A674GFN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/59729:PWP2 ^@ http://purl.uniprot.org/uniprot/H0Z6K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/59729:SDHD ^@ http://purl.uniprot.org/uniprot/B5FZ35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/59729:PSMB3 ^@ http://purl.uniprot.org/uniprot/B5G0S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:ISCA1 ^@ http://purl.uniprot.org/uniprot/H0YQT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/59729:SNRPA1 ^@ http://purl.uniprot.org/uniprot/B5FXA8|||http://purl.uniprot.org/uniprot/H0ZF70 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/59729:ATRNL1 ^@ http://purl.uniprot.org/uniprot/A0A674HPP4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:SLC6A20 ^@ http://purl.uniprot.org/uniprot/H0Z406 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59729:RPL31 ^@ http://purl.uniprot.org/uniprot/B5FX62 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/59729:RPS7 ^@ http://purl.uniprot.org/uniprot/B5FXQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/59729:LCMT1 ^@ http://purl.uniprot.org/uniprot/H0Z764 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/59729:GPN1 ^@ http://purl.uniprot.org/uniprot/H0ZWK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/59729:NIM1K ^@ http://purl.uniprot.org/uniprot/A0A674GGS9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:STMN1 ^@ http://purl.uniprot.org/uniprot/B5G2Z4 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/59729:PHACTR1 ^@ http://purl.uniprot.org/uniprot/A0A674HGZ9 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/59729:SERF1A ^@ http://purl.uniprot.org/uniprot/B5G2W3 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/59729:ATP6V0D2 ^@ http://purl.uniprot.org/uniprot/H0ZNC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59729:NDE1 ^@ http://purl.uniprot.org/uniprot/H0Z4N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/59729:BNIP1 ^@ http://purl.uniprot.org/uniprot/B5FXM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/H0Z662 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59729:CHD6 ^@ http://purl.uniprot.org/uniprot/H0YYE6 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/59729:H2AFV ^@ http://purl.uniprot.org/uniprot/B5G0I6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:DYNLL1 ^@ http://purl.uniprot.org/uniprot/B5G0P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/59729:PTS ^@ http://purl.uniprot.org/uniprot/B5G4P7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PTPS family.|||Binds 1 zinc ion per subunit.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/59729:MEOX1 ^@ http://purl.uniprot.org/uniprot/H0YXK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ERRFI1 ^@ http://purl.uniprot.org/uniprot/H0YWC1 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/59729:PGM1 ^@ http://purl.uniprot.org/uniprot/H0ZI36 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/59729:CRYAB ^@ http://purl.uniprot.org/uniprot/H0YPX8 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/59729:RDX ^@ http://purl.uniprot.org/uniprot/A0A674HAP8 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/59729:SMAD2 ^@ http://purl.uniprot.org/uniprot/A0A674HM63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:PRDM10 ^@ http://purl.uniprot.org/uniprot/H0YQJ9 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/59729:SLC25A34 ^@ http://purl.uniprot.org/uniprot/H0YV15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59729:BRD1 ^@ http://purl.uniprot.org/uniprot/A0A674HL82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:PALS1 ^@ http://purl.uniprot.org/uniprot/A0A674HS90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||tight junction http://togogenome.org/gene/59729:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/A0A674HDH6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:IST1 ^@ http://purl.uniprot.org/uniprot/H0ZD59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/59729:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A674GWT6|||http://purl.uniprot.org/uniprot/A0A674HI18|||http://purl.uniprot.org/uniprot/H0ZK35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/59729:PRDX6 ^@ http://purl.uniprot.org/uniprot/B5G0S1 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/59729:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/A0A674HAN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59729:PIGH ^@ http://purl.uniprot.org/uniprot/A0A674GX35 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/59729:PPP2CA ^@ http://purl.uniprot.org/uniprot/H0YSR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/59729:PARL ^@ http://purl.uniprot.org/uniprot/B5FYH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:MALL ^@ http://purl.uniprot.org/uniprot/H0ZAC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:PDCD5 ^@ http://purl.uniprot.org/uniprot/B5FZV5 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/59729:MINAR1 ^@ http://purl.uniprot.org/uniprot/H0ZCM9 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/59729:DNAJC25 ^@ http://purl.uniprot.org/uniprot/B5FXG7 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/59729:ATP5F1A ^@ http://purl.uniprot.org/uniprot/H0YTM0 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/59729:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A674H9T8|||http://purl.uniprot.org/uniprot/H0Z4E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/59729:LOC100221517 ^@ http://purl.uniprot.org/uniprot/H0YQM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/59729:POLR2J ^@ http://purl.uniprot.org/uniprot/B5G2R1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/59729:S100A1 ^@ http://purl.uniprot.org/uniprot/B5FX85 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/59729:APOD ^@ http://purl.uniprot.org/uniprot/A0A674H772 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/59729:PITX1 ^@ http://purl.uniprot.org/uniprot/H0YSN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/59729:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/H0ZEI0 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/59729:PENK ^@ http://purl.uniprot.org/uniprot/B5FXU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Secreted http://togogenome.org/gene/59729:YIPF1 ^@ http://purl.uniprot.org/uniprot/B5FZ76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/59729:IFT20 ^@ http://purl.uniprot.org/uniprot/B5G0K2 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/59729:ACADL ^@ http://purl.uniprot.org/uniprot/H0ZMD6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/59729:NPM1 ^@ http://purl.uniprot.org/uniprot/B5G0J3 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/59729:HMGN3 ^@ http://purl.uniprot.org/uniprot/B5G1B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/59729:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A674HBF9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:CHAC1 ^@ http://purl.uniprot.org/uniprot/A0A674GYK6 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/59729:CSNK1D ^@ http://purl.uniprot.org/uniprot/A0A674HSS6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:LOC100220008 ^@ http://purl.uniprot.org/uniprot/H0Z5N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/59729:TADA1 ^@ http://purl.uniprot.org/uniprot/A0A674GC23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TADA1 family.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/59729:PLCB1 ^@ http://purl.uniprot.org/uniprot/A0A674GHY6|||http://purl.uniprot.org/uniprot/A0A674GJH3 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/59729:TMEM30A ^@ http://purl.uniprot.org/uniprot/H0ZQX4 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/59729:TMA16 ^@ http://purl.uniprot.org/uniprot/A0A674H172 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/59729:LOC100189939 ^@ http://purl.uniprot.org/uniprot/B5FX51 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/59729:EVA1C ^@ http://purl.uniprot.org/uniprot/H0ZT96 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/59729:LOC100190340 ^@ http://purl.uniprot.org/uniprot/B5G0J1 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/59729:DGCR6L ^@ http://purl.uniprot.org/uniprot/B5KFS0 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/59729:UTP15 ^@ http://purl.uniprot.org/uniprot/H0Z690 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59729:LSM3 ^@ http://purl.uniprot.org/uniprot/B5FXE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/59729:LOC100190105 ^@ http://purl.uniprot.org/uniprot/B5FY49 ^@ Similarity ^@ Belongs to the peptidase S51 family. http://togogenome.org/gene/59729:CENPK ^@ http://purl.uniprot.org/uniprot/H0YX88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/59729:POLR2L ^@ http://purl.uniprot.org/uniprot/B5FYX6 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/59729:GPR89B ^@ http://purl.uniprot.org/uniprot/H0ZTI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/59729:LOC100190610 ^@ http://purl.uniprot.org/uniprot/B5G2X9 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/59729:BARX2 ^@ http://purl.uniprot.org/uniprot/H0YQM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ANTKMT ^@ http://purl.uniprot.org/uniprot/B5G043 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/59729:AK3 ^@ http://purl.uniprot.org/uniprot/B5FYH4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/59729:ABLIM2 ^@ http://purl.uniprot.org/uniprot/A0A674GNN9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59729:EPHA7 ^@ http://purl.uniprot.org/uniprot/A0A674GDN0|||http://purl.uniprot.org/uniprot/H0ZQ33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:HACD4 ^@ http://purl.uniprot.org/uniprot/H0Z1D9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:HIKESHI ^@ http://purl.uniprot.org/uniprot/B5FYG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/59729:ABI2 ^@ http://purl.uniprot.org/uniprot/H0ZHI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/59729:C5H11orf49 ^@ http://purl.uniprot.org/uniprot/A0A674GLT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/59729:LOC100220191 ^@ http://purl.uniprot.org/uniprot/H0ZSJ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59729:CALHM6 ^@ http://purl.uniprot.org/uniprot/H0ZNX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/59729:DPT ^@ http://purl.uniprot.org/uniprot/A0A674HDF4 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/59729:STK39 ^@ http://purl.uniprot.org/uniprot/H0ZB41 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/59729:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/H0ZJX2 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/59729:TSPAN14 ^@ http://purl.uniprot.org/uniprot/A0A674GAQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59729:CHRDL2 ^@ http://purl.uniprot.org/uniprot/H0ZTA5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59729:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/B5FY46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/59729:SOD1 ^@ http://purl.uniprot.org/uniprot/B5G2U2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/59729:MMD ^@ http://purl.uniprot.org/uniprot/H0ZGS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/59729:PSEN2 ^@ http://purl.uniprot.org/uniprot/H0Z1M3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/59729:LOC100219261 ^@ http://purl.uniprot.org/uniprot/B5FZH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:IRF2 ^@ http://purl.uniprot.org/uniprot/A0A674GA53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/59729:SCAMP1 ^@ http://purl.uniprot.org/uniprot/Q0VHR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/59729:RTN1 ^@ http://purl.uniprot.org/uniprot/B5G288 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:NPSR1 ^@ http://purl.uniprot.org/uniprot/H0Z4J9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:INTS2 ^@ http://purl.uniprot.org/uniprot/H0ZBN0 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/59729:RTCA ^@ http://purl.uniprot.org/uniprot/H0Z446 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/59729:LOC100220543 ^@ http://purl.uniprot.org/uniprot/H0ZG86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:MAPK9 ^@ http://purl.uniprot.org/uniprot/A0A674H119|||http://purl.uniprot.org/uniprot/A0A674HMU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/59729:TVP23A ^@ http://purl.uniprot.org/uniprot/B5G137 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/59729:SRP68 ^@ http://purl.uniprot.org/uniprot/H0ZCP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/59729:SIRT4 ^@ http://purl.uniprot.org/uniprot/H0ZGT9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Mitochondrion matrix|||NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. http://togogenome.org/gene/59729:RPS27A ^@ http://purl.uniprot.org/uniprot/H0Z9N6 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/59729:PITHD1 ^@ http://purl.uniprot.org/uniprot/B5FYE5 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/59729:ATP1B2 ^@ http://purl.uniprot.org/uniprot/B5G4P6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/59729:VKORC1L1 ^@ http://purl.uniprot.org/uniprot/H0Z4C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:MYB ^@ http://purl.uniprot.org/uniprot/A0A674HPV3|||http://purl.uniprot.org/uniprot/H0ZMN3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:MRPL15 ^@ http://purl.uniprot.org/uniprot/A0A674GT92 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/59729:RPL26L1 ^@ http://purl.uniprot.org/uniprot/B5G053 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/59729:AP2B1 ^@ http://purl.uniprot.org/uniprot/A0A674HTC3 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/59729:ASIP ^@ http://purl.uniprot.org/uniprot/A0A674GJ99 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59729:LOC100221986 ^@ http://purl.uniprot.org/uniprot/H0ZAD9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:LOC100231656 ^@ http://purl.uniprot.org/uniprot/H0Z1I9 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:CWC15 ^@ http://purl.uniprot.org/uniprot/B5G3N4 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/59729:GPRC6A ^@ http://purl.uniprot.org/uniprot/H0ZNV7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59729:KCNC1 ^@ http://purl.uniprot.org/uniprot/A0A674H3J5|||http://purl.uniprot.org/uniprot/H0ZES6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:LOC100227468 ^@ http://purl.uniprot.org/uniprot/A0A674HGC7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59729:VT1 ^@ http://purl.uniprot.org/uniprot/H0Z5C4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:LOC100218724 ^@ http://purl.uniprot.org/uniprot/A0A674HAK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59729:CERS4 ^@ http://purl.uniprot.org/uniprot/A0A674GKQ3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/59729:FGF2 ^@ http://purl.uniprot.org/uniprot/A0A674GPS1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59729:SLC25A27 ^@ http://purl.uniprot.org/uniprot/B5FXG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59729:GABRA6 ^@ http://purl.uniprot.org/uniprot/H0YT88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59729:INIP ^@ http://purl.uniprot.org/uniprot/B5KFM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Belongs to the multiprotein complex Integrator. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP (By similarity).|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity).|||Nucleus http://togogenome.org/gene/59729:CRH ^@ http://purl.uniprot.org/uniprot/B5FXS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/59729:HSPE1 ^@ http://purl.uniprot.org/uniprot/B5G465 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/59729:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/H0ZS48 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/59729:LOC100189978 ^@ http://purl.uniprot.org/uniprot/B5FXA3 ^@ Function|||Similarity ^@ Belongs to the janus family.|||Exhibits phosphohistidine phosphatase activity. http://togogenome.org/gene/59729:PSMA7 ^@ http://purl.uniprot.org/uniprot/B5G183 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/59729:QRFPR ^@ http://purl.uniprot.org/uniprot/F5HPR9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:ACOT13 ^@ http://purl.uniprot.org/uniprot/B5FXY0 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/59729:TRUB2 ^@ http://purl.uniprot.org/uniprot/B5FZ44 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/59729:MTR ^@ http://purl.uniprot.org/uniprot/H0ZJP8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.|||Cytoplasm|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/59729:GRPEL2 ^@ http://purl.uniprot.org/uniprot/A0A674HRK7 ^@ Similarity ^@ Belongs to the GrpE family. http://togogenome.org/gene/59729:LOC105759119 ^@ http://purl.uniprot.org/uniprot/H0ZSM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/59729:MAP7 ^@ http://purl.uniprot.org/uniprot/A0A674HGF3 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/59729:TIMM22 ^@ http://purl.uniprot.org/uniprot/B5FZU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:PSMA4 ^@ http://purl.uniprot.org/uniprot/B5FXX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/59729:SERPINA10 ^@ http://purl.uniprot.org/uniprot/H1A5K6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59729:CTNNB1 ^@ http://purl.uniprot.org/uniprot/H0Z303 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/59729:TMSB15B ^@ http://purl.uniprot.org/uniprot/B5G1J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/59729:LOC100224417 ^@ http://purl.uniprot.org/uniprot/H0ZG44 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:LOC100231862 ^@ http://purl.uniprot.org/uniprot/H0ZDW2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59729:LOC100221351 ^@ http://purl.uniprot.org/uniprot/A0A674HTI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/59729:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/H0ZQT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:USP15 ^@ http://purl.uniprot.org/uniprot/A0A674H961 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:SOST ^@ http://purl.uniprot.org/uniprot/H0YXK3 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A674GVA5 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/59729:RPL30 ^@ http://purl.uniprot.org/uniprot/B5FYY0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/59729:LOC100218765 ^@ http://purl.uniprot.org/uniprot/H0Z348 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/59729:SVBP ^@ http://purl.uniprot.org/uniprot/B5FZ42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Cytoplasm|||Enhances the tyrosine carboxypeptidase activity of vash1 and vash2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of vash1 and vash2. May play a role in axon and excitatory synapse formation (By similarity).|||Secreted|||cytoskeleton http://togogenome.org/gene/59729:NEUROD6 ^@ http://purl.uniprot.org/uniprot/H0YUK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:PFDN1 ^@ http://purl.uniprot.org/uniprot/B5G1I3 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/59729:SEC23B ^@ http://purl.uniprot.org/uniprot/A0A674HM95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/59729:UBLCP1 ^@ http://purl.uniprot.org/uniprot/H0YQN3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/B5FYY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.|||Belongs to the GAMAD family.|||Late endosome membrane|||Lysosome membrane|||Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC). http://togogenome.org/gene/59729:DLX6 ^@ http://purl.uniprot.org/uniprot/H0YTS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:CPOX ^@ http://purl.uniprot.org/uniprot/H0ZT91 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/59729:KCND2 ^@ http://purl.uniprot.org/uniprot/H0Z2N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/59729:HMX2 ^@ http://purl.uniprot.org/uniprot/H0ZMA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:LOC100227127 ^@ http://purl.uniprot.org/uniprot/H0YUS5 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:PARN ^@ http://purl.uniprot.org/uniprot/H0Z3M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm http://togogenome.org/gene/59729:NSMCE1 ^@ http://purl.uniprot.org/uniprot/B5FYL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/59729:LOC100227340 ^@ http://purl.uniprot.org/uniprot/H0ZN92 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:SDAD1 ^@ http://purl.uniprot.org/uniprot/H0YTV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/59729:TPRG1L ^@ http://purl.uniprot.org/uniprot/H0YX21 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/59729:ZRANB1 ^@ http://purl.uniprot.org/uniprot/H0ZMI9 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/59729:LOC100222235 ^@ http://purl.uniprot.org/uniprot/H0Z817 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/59729:POLR3A ^@ http://purl.uniprot.org/uniprot/H0Z7T8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/59729:LOC101234126 ^@ http://purl.uniprot.org/uniprot/H1A1X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/59729:ATIC ^@ http://purl.uniprot.org/uniprot/H0YXN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PurH family.|||cytosol http://togogenome.org/gene/59729:IL12B ^@ http://purl.uniprot.org/uniprot/H0YPL2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-12B family.|||Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Secreted http://togogenome.org/gene/59729:PISD ^@ http://purl.uniprot.org/uniprot/A0A674HU15 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:LOC100228369 ^@ http://purl.uniprot.org/uniprot/B5FXY4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:MED13 ^@ http://purl.uniprot.org/uniprot/H0ZBK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59729:LAMP5 ^@ http://purl.uniprot.org/uniprot/A0A674GQU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/59729:LOC100226875 ^@ http://purl.uniprot.org/uniprot/H0ZQQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:ADSS2 ^@ http://purl.uniprot.org/uniprot/A0A674HAV6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/59729:TPI1 ^@ http://purl.uniprot.org/uniprot/B5KFL8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer.|||It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.|||Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. http://togogenome.org/gene/59729:SLC2A13 ^@ http://purl.uniprot.org/uniprot/A0A674HAZ7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59729:CLTA ^@ http://purl.uniprot.org/uniprot/A0A674GRU1|||http://purl.uniprot.org/uniprot/B5FYI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/59729:DDX5 ^@ http://purl.uniprot.org/uniprot/A0A674GR94 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/59729:KCNMB1 ^@ http://purl.uniprot.org/uniprot/A0A674HHC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:PPIL1 ^@ http://purl.uniprot.org/uniprot/B5FXA7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59729:CMTR1 ^@ http://purl.uniprot.org/uniprot/H0ZC72 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1). http://togogenome.org/gene/59729:MRPL17 ^@ http://purl.uniprot.org/uniprot/B5FYN0|||http://purl.uniprot.org/uniprot/B5FYN4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/59729:HBAP ^@ http://purl.uniprot.org/uniprot/H0Z1T1 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59729:LOC100230245 ^@ http://purl.uniprot.org/uniprot/A0A674HT40 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/59729:EBF2 ^@ http://purl.uniprot.org/uniprot/H0Z1M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/59729:PIP4P2 ^@ http://purl.uniprot.org/uniprot/H0ZNL6 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/59729:CNOT7 ^@ http://purl.uniprot.org/uniprot/H0ZA68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/59729:PSIP1 ^@ http://purl.uniprot.org/uniprot/H0Z283 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/59729:PFDN2 ^@ http://purl.uniprot.org/uniprot/B5FXU2 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/59729:YWHAG ^@ http://purl.uniprot.org/uniprot/B5G028 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/59729:ST6GALNAC3 ^@ http://purl.uniprot.org/uniprot/A0A674GPF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59729:ERLEC1 ^@ http://purl.uniprot.org/uniprot/H0ZA92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/59729:SPC25 ^@ http://purl.uniprot.org/uniprot/A0A674H6M8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/59729:KLC1 ^@ http://purl.uniprot.org/uniprot/A0A674HGD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/59729:TMEM267 ^@ http://purl.uniprot.org/uniprot/A0A674HSI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:HADH ^@ http://purl.uniprot.org/uniprot/H0Z0N4 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/59729:TMEM167A ^@ http://purl.uniprot.org/uniprot/B5G2S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway. http://togogenome.org/gene/59729:LHPP ^@ http://purl.uniprot.org/uniprot/B5G164 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/59729:DPCD ^@ http://purl.uniprot.org/uniprot/B5FXE0 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/59729:NSFL1C ^@ http://purl.uniprot.org/uniprot/B5KFR1 ^@ Subcellular Location Annotation ^@ Golgi stack http://togogenome.org/gene/59729:ESF1 ^@ http://purl.uniprot.org/uniprot/H0YW48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/59729:WNT7A ^@ http://purl.uniprot.org/uniprot/H0YZX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59729:SF3B1 ^@ http://purl.uniprot.org/uniprot/A0A674GB95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/59729:WT1 ^@ http://purl.uniprot.org/uniprot/A0A674GAA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/59729:ANKRD13A ^@ http://purl.uniprot.org/uniprot/H0ZAW2 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/59729:RPS6KB1 ^@ http://purl.uniprot.org/uniprot/H0ZBF2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/59729:ATP5F1E ^@ http://purl.uniprot.org/uniprot/B5G0S9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/59729:HOXA6 ^@ http://purl.uniprot.org/uniprot/H0YXH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/59729:SLC22A4 ^@ http://purl.uniprot.org/uniprot/A0A674H847 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Basal cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/59729:EIF1 ^@ http://purl.uniprot.org/uniprot/B5G1X8 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/59729:PPP2R5C ^@ http://purl.uniprot.org/uniprot/H0ZRC7 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/59729:EVL ^@ http://purl.uniprot.org/uniprot/H0ZR82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||cytoskeleton http://togogenome.org/gene/59729:RSPO1 ^@ http://purl.uniprot.org/uniprot/H0YTH5 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/59729:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A674G9U9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/59729:REEP3 ^@ http://purl.uniprot.org/uniprot/A0A674H7I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/59729:EEF2K ^@ http://purl.uniprot.org/uniprot/A0A674GAV1|||http://purl.uniprot.org/uniprot/A0A674GPZ9|||http://purl.uniprot.org/uniprot/A0A674HKW0 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. Alpha-type protein kinase family.|||Monomer or homodimer.|||Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. http://togogenome.org/gene/59729:GNB1 ^@ http://purl.uniprot.org/uniprot/H0YXS3 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/59729:TMEM50A ^@ http://purl.uniprot.org/uniprot/B5G2J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/59729:EEF1AKMT2 ^@ http://purl.uniprot.org/uniprot/H0ZMH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||Nucleus|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. http://togogenome.org/gene/59729:DR1 ^@ http://purl.uniprot.org/uniprot/H0Z693 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/59729:AHSA2P ^@ http://purl.uniprot.org/uniprot/B5FYC5 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/59729:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/E4ZFH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59729:CIRBP ^@ http://purl.uniprot.org/uniprot/B5G1F8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm http://togogenome.org/gene/59729:RRAGC ^@ http://purl.uniprot.org/uniprot/A0A674GKM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/59729:PITX3 ^@ http://purl.uniprot.org/uniprot/H0ZAM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/59729:ITGB6 ^@ http://purl.uniprot.org/uniprot/H0Z879 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:FKTN ^@ http://purl.uniprot.org/uniprot/H0Z7E9 ^@ Similarity ^@ Belongs to the LicD transferase family. http://togogenome.org/gene/59729:MTNR1B ^@ http://purl.uniprot.org/uniprot/Q3LTL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:SCARB2 ^@ http://purl.uniprot.org/uniprot/B5FY06 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/59729:JAGN1 ^@ http://purl.uniprot.org/uniprot/B5G4P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:FOXP2 ^@ http://purl.uniprot.org/uniprot/Q6QBA5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:RPS9 ^@ http://purl.uniprot.org/uniprot/B5FX48 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/59729:ARF6 ^@ http://purl.uniprot.org/uniprot/B5G0L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/59729:LOC100218976 ^@ http://purl.uniprot.org/uniprot/H0ZHC5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59729:LOC100230612 ^@ http://purl.uniprot.org/uniprot/A0A674GJB7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/59729:OTULINL ^@ http://purl.uniprot.org/uniprot/H0ZAQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/59729:PIGO ^@ http://purl.uniprot.org/uniprot/H0YU60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:ATP2A2 ^@ http://purl.uniprot.org/uniprot/H0Z5X4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/59729:SNX5 ^@ http://purl.uniprot.org/uniprot/H0Z6C1 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/59729:FABP7 ^@ http://purl.uniprot.org/uniprot/H0ZNK7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59729:CHST10 ^@ http://purl.uniprot.org/uniprot/H0ZIF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:IFNG ^@ http://purl.uniprot.org/uniprot/A0A674HE98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.|||Secreted http://togogenome.org/gene/59729:GRIN2B ^@ http://purl.uniprot.org/uniprot/H0ZGP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/59729:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A674H6D9|||http://purl.uniprot.org/uniprot/H0Z8X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/59729:APRT ^@ http://purl.uniprot.org/uniprot/B5FX92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm http://togogenome.org/gene/59729:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/A0A674H5W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/59729:LOC100228825 ^@ http://purl.uniprot.org/uniprot/H0ZP91 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59729:SYNPR ^@ http://purl.uniprot.org/uniprot/A0A674H1P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/59729:MRPL28 ^@ http://purl.uniprot.org/uniprot/B5G132 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/59729:IGF2 ^@ http://purl.uniprot.org/uniprot/O57687 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/59729:LOC100227575 ^@ http://purl.uniprot.org/uniprot/B5FYB1 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/59729:FYN ^@ http://purl.uniprot.org/uniprot/H0ZP43 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59729:B3GNT2 ^@ http://purl.uniprot.org/uniprot/H0YVG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:SLC39A3 ^@ http://purl.uniprot.org/uniprot/A0A674HEH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:FGG ^@ http://purl.uniprot.org/uniprot/H0Z4E6 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/59729:NDUFB4 ^@ http://purl.uniprot.org/uniprot/B5G2C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:ETFRF1 ^@ http://purl.uniprot.org/uniprot/B5FXA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB).|||Belongs to the complex I LYR family.|||Mitochondrion http://togogenome.org/gene/59729:RO60 ^@ http://purl.uniprot.org/uniprot/H0Z128 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/59729:LDHB ^@ http://purl.uniprot.org/uniprot/B5G2G0 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/59729:NCDN ^@ http://purl.uniprot.org/uniprot/H0YTW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/59729:TSHZ1 ^@ http://purl.uniprot.org/uniprot/A0A674H6E4 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/59729:EIF5 ^@ http://purl.uniprot.org/uniprot/H0ZRI5 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/59729:MFSD14A ^@ http://purl.uniprot.org/uniprot/H0Z4G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/59729:LAMP1 ^@ http://purl.uniprot.org/uniprot/H0ZFX0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/59729:LOC100232209 ^@ http://purl.uniprot.org/uniprot/H0ZG86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:COPS4 ^@ http://purl.uniprot.org/uniprot/H0YX45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/59729:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/H0ZES1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/59729:CIAO2A ^@ http://purl.uniprot.org/uniprot/B5FXS7 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/59729:RNF121 ^@ http://purl.uniprot.org/uniprot/B5FY54 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:CDC73 ^@ http://purl.uniprot.org/uniprot/A0A674GIB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC73 family.|||Nucleus http://togogenome.org/gene/59729:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A674HQ78|||http://purl.uniprot.org/uniprot/A0A674HU73 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/59729:FAM72A ^@ http://purl.uniprot.org/uniprot/A0A674HG84 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/59729:LOC100227529 ^@ http://purl.uniprot.org/uniprot/H0ZT85 ^@ Similarity ^@ Belongs to the intercrine gamma family. http://togogenome.org/gene/59729:TMEM230 ^@ http://purl.uniprot.org/uniprot/B5FZ43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/59729:LOC100228872 ^@ http://purl.uniprot.org/uniprot/H0ZA72 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59729:UTS2B ^@ http://purl.uniprot.org/uniprot/H0ZG50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/59729:LOC100190592 ^@ http://purl.uniprot.org/uniprot/B5KFR9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59729:TMEM50B ^@ http://purl.uniprot.org/uniprot/B5FYJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/59729:SERPINI1 ^@ http://purl.uniprot.org/uniprot/B5G464 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59729:DNAJA1 ^@ http://purl.uniprot.org/uniprot/B5G121 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/B5FXF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/59729:RORA ^@ http://purl.uniprot.org/uniprot/H0Z4K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59729:WIF1 ^@ http://purl.uniprot.org/uniprot/H0Z857 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59729:PDCD4 ^@ http://purl.uniprot.org/uniprot/H0ZZ88 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/59729:RPL22L1 ^@ http://purl.uniprot.org/uniprot/B5FYE7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/59729:TBC1D24 ^@ http://purl.uniprot.org/uniprot/A0A674H1J1|||http://purl.uniprot.org/uniprot/A0A674HF88 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/59729:SLC25A5 ^@ http://purl.uniprot.org/uniprot/B5FYE2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/59729:NDUFA12 ^@ http://purl.uniprot.org/uniprot/B5G168 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:INTS14 ^@ http://purl.uniprot.org/uniprot/H0ZVU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/59729:RAB21 ^@ http://purl.uniprot.org/uniprot/H0ZA75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cleavage furrow|||Early endosome membrane|||Endoplasmic reticulum membrane|||trans-Golgi network http://togogenome.org/gene/59729:PDPR ^@ http://purl.uniprot.org/uniprot/H0Z783 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/59729:LSM6 ^@ http://purl.uniprot.org/uniprot/B5FY51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/59729:IFITM10 ^@ http://purl.uniprot.org/uniprot/H0ZGM3 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/59729:ATG101 ^@ http://purl.uniprot.org/uniprot/B5G0T4 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/59729:SNU13 ^@ http://purl.uniprot.org/uniprot/B5FZ04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/59729:SERF2 ^@ http://purl.uniprot.org/uniprot/B5G4D4 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/59729:KCNG3 ^@ http://purl.uniprot.org/uniprot/A0A674HSX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:DPM1 ^@ http://purl.uniprot.org/uniprot/B5FZV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/59729:DERL3 ^@ http://purl.uniprot.org/uniprot/B5FZE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/59729:GJB1 ^@ http://purl.uniprot.org/uniprot/B5KFG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59729:ASF1A ^@ http://purl.uniprot.org/uniprot/A0A674HJ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/59729:CALHM2 ^@ http://purl.uniprot.org/uniprot/H0ZJ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/59729:LOC100222284 ^@ http://purl.uniprot.org/uniprot/A0A674H4G9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/59729:ZFYVE27 ^@ http://purl.uniprot.org/uniprot/H0ZH27|||http://purl.uniprot.org/uniprot/H0ZH30 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||growth cone membrane http://togogenome.org/gene/59729:CD28 ^@ http://purl.uniprot.org/uniprot/H1A2C2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:ABHD2 ^@ http://purl.uniprot.org/uniprot/H0ZD64 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/59729:GEMIN2 ^@ http://purl.uniprot.org/uniprot/H0ZP71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gemin-2 family.|||Cytoplasm|||Part of the core SMN complex.|||The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. http://togogenome.org/gene/59729:HTR5A ^@ http://purl.uniprot.org/uniprot/H0YQZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:PCNA ^@ http://purl.uniprot.org/uniprot/B5KFN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/59729:SLC6A14 ^@ http://purl.uniprot.org/uniprot/A0A674HIJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59729:PSME3 ^@ http://purl.uniprot.org/uniprot/B5FZN7 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/59729:GALNT4 ^@ http://purl.uniprot.org/uniprot/A0A674GAP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:ACSL4 ^@ http://purl.uniprot.org/uniprot/A0A674GDY0|||http://purl.uniprot.org/uniprot/A0A674H646 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59729:LOC100226496 ^@ http://purl.uniprot.org/uniprot/A0A674GCG6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:NDUFA3 ^@ http://purl.uniprot.org/uniprot/B5G0G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA3 subunit family.|||Complex I is composed of 45 different subunits.|||Membrane http://togogenome.org/gene/59729:CD38 ^@ http://purl.uniprot.org/uniprot/H0ZHK5 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/59729:FUCA2 ^@ http://purl.uniprot.org/uniprot/H0ZL71 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/59729:SMU1 ^@ http://purl.uniprot.org/uniprot/H0YT94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/59729:PTPA ^@ http://purl.uniprot.org/uniprot/A0A674HRX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59729:TECRL ^@ http://purl.uniprot.org/uniprot/H0YXI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/59729:MAP3K5 ^@ http://purl.uniprot.org/uniprot/H0ZKT1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/59729:ARV1 ^@ http://purl.uniprot.org/uniprot/A0A674GEA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/59729:TBL1X ^@ http://purl.uniprot.org/uniprot/A0A674HKW1 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/59729:NDUFB9 ^@ http://purl.uniprot.org/uniprot/B5FZL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:SEM1 ^@ http://purl.uniprot.org/uniprot/B5G0H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/59729:CKS2 ^@ http://purl.uniprot.org/uniprot/H0YQA1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/59729:PRDX1 ^@ http://purl.uniprot.org/uniprot/B5G0L9|||http://purl.uniprot.org/uniprot/B5G0N0 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/59729:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/B5FXD8 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/59729:SLC16A7 ^@ http://purl.uniprot.org/uniprot/A0A674HNK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/59729:HSPA4 ^@ http://purl.uniprot.org/uniprot/H0YPI8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/59729:FAM162A ^@ http://purl.uniprot.org/uniprot/A0A674HMM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/59729:HTR1D ^@ http://purl.uniprot.org/uniprot/H0YT67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:LOC100225066 ^@ http://purl.uniprot.org/uniprot/A0A674HPM4 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/59729:PPIA ^@ http://purl.uniprot.org/uniprot/B5G3G3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59729:MRPL2 ^@ http://purl.uniprot.org/uniprot/B5FYM2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/59729:SCRN1 ^@ http://purl.uniprot.org/uniprot/A0A674GR34 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/59729:NFRKB ^@ http://purl.uniprot.org/uniprot/A0A674GWM7|||http://purl.uniprot.org/uniprot/A0A674HHU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A674HE10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/59729:CLCN3 ^@ http://purl.uniprot.org/uniprot/H0Z719 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/59729:LOC100219012 ^@ http://purl.uniprot.org/uniprot/H0YQP8 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/59729:ATG16L1 ^@ http://purl.uniprot.org/uniprot/H0ZAN7 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/59729:MRPS36 ^@ http://purl.uniprot.org/uniprot/B5FX64 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/59729:LOC100222674 ^@ http://purl.uniprot.org/uniprot/H0YXV3 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:HOXC9 ^@ http://purl.uniprot.org/uniprot/H0ZVN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/59729:HEXIM1 ^@ http://purl.uniprot.org/uniprot/B5FXM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/59729:MTIF2 ^@ http://purl.uniprot.org/uniprot/H0Z9N2 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/59729:CTSD ^@ http://purl.uniprot.org/uniprot/A0A674HIU5 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/59729:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A674HTG2 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/59729:SLC7A2 ^@ http://purl.uniprot.org/uniprot/A0A674GP60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:MBTPS1 ^@ http://purl.uniprot.org/uniprot/H0Z8L6 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/59729:PHETA2 ^@ http://purl.uniprot.org/uniprot/A0A674HE44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sesquipedalian family.|||Early endosome|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/59729:MTNR1A ^@ http://purl.uniprot.org/uniprot/Q0ZAL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:SGSM3 ^@ http://purl.uniprot.org/uniprot/A0A674GVM6 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/59729:LOC100222004 ^@ http://purl.uniprot.org/uniprot/H0Z1I4 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:NDUFV2 ^@ http://purl.uniprot.org/uniprot/B5G0Q5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/59729:ATP5F1C ^@ http://purl.uniprot.org/uniprot/B5G252 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/59729:LOC100226754 ^@ http://purl.uniprot.org/uniprot/H0YUV2 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/59729:HPCAL1 ^@ http://purl.uniprot.org/uniprot/B5FZ84 ^@ Miscellaneous|||Similarity ^@ Belongs to the recoverin family.|||Probably binds two or three calcium ions. http://togogenome.org/gene/59729:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/B5KFM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/59729:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A674GPV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/59729:MRPL32 ^@ http://purl.uniprot.org/uniprot/B5G050 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/59729:GPT2 ^@ http://purl.uniprot.org/uniprot/H0ZEU3 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/59729:LPAR3 ^@ http://purl.uniprot.org/uniprot/H0Z7Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:WNT2 ^@ http://purl.uniprot.org/uniprot/H0Z3P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59729:APLP2 ^@ http://purl.uniprot.org/uniprot/H0YQL6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:PDE6G ^@ http://purl.uniprot.org/uniprot/A0A674GI71 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/59729:FMR1 ^@ http://purl.uniprot.org/uniprot/B6CVD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Stress granule|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/59729:METAP1 ^@ http://purl.uniprot.org/uniprot/H0YYQ8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/59729:NDUFB6 ^@ http://purl.uniprot.org/uniprot/B5FXY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:NDUFB2 ^@ http://purl.uniprot.org/uniprot/B5G0G6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:SLC17A6 ^@ http://purl.uniprot.org/uniprot/V9XYM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:CDC42 ^@ http://purl.uniprot.org/uniprot/A0A674HL77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/59729:COX7C ^@ http://purl.uniprot.org/uniprot/B5FZB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:LOC100225385 ^@ http://purl.uniprot.org/uniprot/H0ZFM3 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/59729:DGKB ^@ http://purl.uniprot.org/uniprot/A0A674G776|||http://purl.uniprot.org/uniprot/A0A674GN14 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/59729:CHD1W ^@ http://purl.uniprot.org/uniprot/Q7ZT34 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:TFB1M ^@ http://purl.uniprot.org/uniprot/H0ZLK5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/59729:CYBASC3 ^@ http://purl.uniprot.org/uniprot/B5FX86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:PAX5 ^@ http://purl.uniprot.org/uniprot/A0A674GVC1|||http://purl.uniprot.org/uniprot/A0A674HPM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:NACC2 ^@ http://purl.uniprot.org/uniprot/A0A674GS50 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:GPR20 ^@ http://purl.uniprot.org/uniprot/H0ZR29 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:CDR2 ^@ http://purl.uniprot.org/uniprot/A0A674HRF6 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/59729:LOC100228379 ^@ http://purl.uniprot.org/uniprot/H0Z1C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Has antiviral activities.|||Secreted http://togogenome.org/gene/59729:HSPD1 ^@ http://purl.uniprot.org/uniprot/H0ZJV4 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/59729:RARB ^@ http://purl.uniprot.org/uniprot/A0A674GGN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/59729:LAPTM5 ^@ http://purl.uniprot.org/uniprot/H0YRB1 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/59729:PDRG1 ^@ http://purl.uniprot.org/uniprot/B5FYS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/59729:LOC100224175 ^@ http://purl.uniprot.org/uniprot/A0A674GGT7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59729:PSEN1 ^@ http://purl.uniprot.org/uniprot/A0A674GY85 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/59729:YEATS4 ^@ http://purl.uniprot.org/uniprot/H0Z946|||http://purl.uniprot.org/uniprot/H0ZVE5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:TBC1D7 ^@ http://purl.uniprot.org/uniprot/H0Z636 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/59729:CMPK1 ^@ http://purl.uniprot.org/uniprot/A0A674GJ51 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/59729:LRP12 ^@ http://purl.uniprot.org/uniprot/H0ZPL9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:LOC100190507 ^@ http://purl.uniprot.org/uniprot/B5G401 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59729:DCTN4 ^@ http://purl.uniprot.org/uniprot/A0A674HCV9|||http://purl.uniprot.org/uniprot/H0YRF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/59729:SLC25A6 ^@ http://purl.uniprot.org/uniprot/B5FYE3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/59729:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/B5FYZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/59729:BZW1 ^@ http://purl.uniprot.org/uniprot/H0ZJG2 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/59729:OSGEP ^@ http://purl.uniprot.org/uniprot/B5FXN3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:NT5C2 ^@ http://purl.uniprot.org/uniprot/A0A674GKN4 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/59729:NDFIP1 ^@ http://purl.uniprot.org/uniprot/B5FYV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:CHMP5 ^@ http://purl.uniprot.org/uniprot/B5G281 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/59729:STAC ^@ http://purl.uniprot.org/uniprot/H0YTX9 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/59729:ENPP3 ^@ http://purl.uniprot.org/uniprot/H0ZN45 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59729:CFAP206 ^@ http://purl.uniprot.org/uniprot/H0ZQD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme http://togogenome.org/gene/59729:PSME3IP1 ^@ http://purl.uniprot.org/uniprot/B5G2E8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A674HHL6|||http://purl.uniprot.org/uniprot/H0YSY6 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/59729:LIPI ^@ http://purl.uniprot.org/uniprot/H0ZTJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/59729:FGF8 ^@ http://purl.uniprot.org/uniprot/H0ZI62 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59729:PRR5L ^@ http://purl.uniprot.org/uniprot/H0ZIN6 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/59729:GPR183 ^@ http://purl.uniprot.org/uniprot/H0ZL26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:OPN1SW ^@ http://purl.uniprot.org/uniprot/Q9I8R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/59729:ORC3 ^@ http://purl.uniprot.org/uniprot/H0ZQB9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/59729:AURKAIP1 ^@ http://purl.uniprot.org/uniprot/B5G3E7 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mS38 family. http://togogenome.org/gene/59729:ADCY5 ^@ http://purl.uniprot.org/uniprot/H0Z1K3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/59729:CCNK ^@ http://purl.uniprot.org/uniprot/H0ZR50 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/59729:LOC100231703 ^@ http://purl.uniprot.org/uniprot/H0YT41 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/59729:MRPL30 ^@ http://purl.uniprot.org/uniprot/B5FZK5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/59729:RPL11 ^@ http://purl.uniprot.org/uniprot/H0YSI9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/59729:TOMM7 ^@ http://purl.uniprot.org/uniprot/B5G498 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59729:RPS13 ^@ http://purl.uniprot.org/uniprot/B5FZH6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/59729:GET4 ^@ http://purl.uniprot.org/uniprot/B5KFI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.|||Belongs to the GET4 family.|||Component of the BAG6/BAT3 complex.|||cytosol http://togogenome.org/gene/59729:SLC7A3 ^@ http://purl.uniprot.org/uniprot/A0A674GPY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:OST4 ^@ http://purl.uniprot.org/uniprot/B5G114 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/B5FZN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||cytoskeleton http://togogenome.org/gene/59729:EZH2 ^@ http://purl.uniprot.org/uniprot/A0A674H2E7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:LTA4H ^@ http://purl.uniprot.org/uniprot/H0ZE27 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/59729:LOC100231893 ^@ http://purl.uniprot.org/uniprot/H0YPJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:LOC100190349 ^@ http://purl.uniprot.org/uniprot/B5G0N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/59729:CTNNA2 ^@ http://purl.uniprot.org/uniprot/H0ZKY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/59729:GPX4 ^@ http://purl.uniprot.org/uniprot/B5G1Z5 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/59729:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/H0YX46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Cytoplasm http://togogenome.org/gene/59729:RAD52 ^@ http://purl.uniprot.org/uniprot/H0ZQU2 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/59729:LOC100220117 ^@ http://purl.uniprot.org/uniprot/A0A674H483 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59729:CDH12 ^@ http://purl.uniprot.org/uniprot/H0YUL2 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/59729:FAM83B ^@ http://purl.uniprot.org/uniprot/H0ZRI3 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/59729:MB ^@ http://purl.uniprot.org/uniprot/H0ZKN4 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/59729:PPT1 ^@ http://purl.uniprot.org/uniprot/B5FZ59 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/59729:CSF1R ^@ http://purl.uniprot.org/uniprot/D8UWE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A674GKU0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59729:NEU2 ^@ http://purl.uniprot.org/uniprot/K0Q564 ^@ Miscellaneous|||Similarity ^@ Belongs to the glycosyl hydrolase 33 family.|||The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry. http://togogenome.org/gene/59729:ELOVL2 ^@ http://purl.uniprot.org/uniprot/B5G3Z3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL2 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/59729:GPNMB ^@ http://purl.uniprot.org/uniprot/H0YX20 ^@ Similarity ^@ Belongs to the PMEL/NMB family. http://togogenome.org/gene/59729:CZH18orf32 ^@ http://purl.uniprot.org/uniprot/B5G0I2 ^@ Similarity ^@ Belongs to the UPF0729 family. http://togogenome.org/gene/59729:EXOC7 ^@ http://purl.uniprot.org/uniprot/H0ZCL0 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/59729:RTCB ^@ http://purl.uniprot.org/uniprot/H0ZL18 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/59729:PRIM2 ^@ http://purl.uniprot.org/uniprot/H0ZRC8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. http://togogenome.org/gene/59729:ARPP19 ^@ http://purl.uniprot.org/uniprot/B5G1C4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the endosulfine family.|||Cytoplasm|||Interacts (when phosphorylated at Ser-62) with PPP2R2D.|||Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A.|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). http://togogenome.org/gene/59729:TAGLN3 ^@ http://purl.uniprot.org/uniprot/B5FZX6|||http://purl.uniprot.org/uniprot/B5FZX7 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/59729:CX3CR1 ^@ http://purl.uniprot.org/uniprot/H1A5U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/59729:RPP14 ^@ http://purl.uniprot.org/uniprot/B5FXA5 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/59729:CENPN ^@ http://purl.uniprot.org/uniprot/H0Z2C2 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/59729:UGP2 ^@ http://purl.uniprot.org/uniprot/H0YVL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/59729:VOPP1 ^@ http://purl.uniprot.org/uniprot/B5G0C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/59729:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A674H7X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/59729:MAB21L2 ^@ http://purl.uniprot.org/uniprot/H0YWF2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/59729:OGN ^@ http://purl.uniprot.org/uniprot/A0A674GB69 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/59729:NDUFC2 ^@ http://purl.uniprot.org/uniprot/B5FXS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:SLC6A17 ^@ http://purl.uniprot.org/uniprot/A0A674HE88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59729:POLR2H ^@ http://purl.uniprot.org/uniprot/B5FXF5 ^@ Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family. http://togogenome.org/gene/59729:RPL27 ^@ http://purl.uniprot.org/uniprot/B5FZY2|||http://purl.uniprot.org/uniprot/B5FZY5|||http://purl.uniprot.org/uniprot/B5FZY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/59729:COPS5 ^@ http://purl.uniprot.org/uniprot/B5FYR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/59729:COPS9 ^@ http://purl.uniprot.org/uniprot/B5FZI1 ^@ Similarity ^@ Belongs to the CSN9 family. http://togogenome.org/gene/59729:GEM ^@ http://purl.uniprot.org/uniprot/H0ZNR0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/59729:MTM1 ^@ http://purl.uniprot.org/uniprot/A0A674H098 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/59729:LOC100224299 ^@ http://purl.uniprot.org/uniprot/H0YP39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/59729:LOC100220807 ^@ http://purl.uniprot.org/uniprot/A0A674GMJ5 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/59729:TNFSF15 ^@ http://purl.uniprot.org/uniprot/H0YYA7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/59729:BASP1 ^@ http://purl.uniprot.org/uniprot/B5G2C2 ^@ Similarity ^@ Belongs to the BASP1 family. http://togogenome.org/gene/59729:AQP1 ^@ http://purl.uniprot.org/uniprot/A0A674HCV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/59729:DMBX1 ^@ http://purl.uniprot.org/uniprot/H0ZDE1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:NDUFA1 ^@ http://purl.uniprot.org/uniprot/B5G1H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:LOC100229375 ^@ http://purl.uniprot.org/uniprot/H0Z3C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Membrane http://togogenome.org/gene/59729:MOV10 ^@ http://purl.uniprot.org/uniprot/H1A4J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/59729:C17H9orf78 ^@ http://purl.uniprot.org/uniprot/H0Z236 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/59729:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A674HFQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/59729:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A674GRS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59729:FAM133B ^@ http://purl.uniprot.org/uniprot/B5G0R6 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/59729:KEG28_p01 ^@ http://purl.uniprot.org/uniprot/Q27GV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/59729:TMEM39A ^@ http://purl.uniprot.org/uniprot/H0ZT45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/59729:CPN1 ^@ http://purl.uniprot.org/uniprot/H0ZFU2 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/59729:CDKN1B ^@ http://purl.uniprot.org/uniprot/B5FXL7 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/59729:MANF ^@ http://purl.uniprot.org/uniprot/B5FZV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/59729:CLTB ^@ http://purl.uniprot.org/uniprot/A0A674GU09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/59729:TBK1 ^@ http://purl.uniprot.org/uniprot/H0Z7Z2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59729:LOC100189940 ^@ http://purl.uniprot.org/uniprot/B5FX53 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/59729:MDH2 ^@ http://purl.uniprot.org/uniprot/B5G3E2 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/59729:AGPAT5 ^@ http://purl.uniprot.org/uniprot/B5FXF9 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59729:ASCC3 ^@ http://purl.uniprot.org/uniprot/H0ZPV5 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/59729:OPN5 ^@ http://purl.uniprot.org/uniprot/A0A674HDZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59729:DDX17 ^@ http://purl.uniprot.org/uniprot/H0ZJG0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/59729:CSTF3 ^@ http://purl.uniprot.org/uniprot/H0Z3Q7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:MSRA ^@ http://purl.uniprot.org/uniprot/H0ZSW6 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/59729:MOXD1 ^@ http://purl.uniprot.org/uniprot/H0ZN04 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/59729:GIMD1 ^@ http://purl.uniprot.org/uniprot/H0Z0F0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/59729:B3GNT4 ^@ http://purl.uniprot.org/uniprot/H0Z6Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:LOC100190710 ^@ http://purl.uniprot.org/uniprot/B5G1B6 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/59729:TJAP1 ^@ http://purl.uniprot.org/uniprot/A0A674HCI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:TINAG ^@ http://purl.uniprot.org/uniprot/H0ZRI4 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/59729:FGF10 ^@ http://purl.uniprot.org/uniprot/A0A674H506 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59729:ZFPM2 ^@ http://purl.uniprot.org/uniprot/A0A674HC26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A674GDV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:RAD1 ^@ http://purl.uniprot.org/uniprot/H0YUP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/59729:TCEA3 ^@ http://purl.uniprot.org/uniprot/H0YRP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/59729:PDE9A ^@ http://purl.uniprot.org/uniprot/H0Z5P0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59729:SEC61B ^@ http://purl.uniprot.org/uniprot/B5FZ77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/59729:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A674GX41|||http://purl.uniprot.org/uniprot/B5KFS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59729:STMN3 ^@ http://purl.uniprot.org/uniprot/B5FXL5 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/59729:GADD45G ^@ http://purl.uniprot.org/uniprot/A0A674GTY1 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/59729:MRPS11 ^@ http://purl.uniprot.org/uniprot/B5G490 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/59729:MPPED2 ^@ http://purl.uniprot.org/uniprot/A0A674H9Y6 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/59729:AP3S1 ^@ http://purl.uniprot.org/uniprot/A0A674GSQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/59729:IL6ST ^@ http://purl.uniprot.org/uniprot/A0A674HAB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/59729:RPL35A ^@ http://purl.uniprot.org/uniprot/B5FYA0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/59729:LOC100228347 ^@ http://purl.uniprot.org/uniprot/H0Z925 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59729:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A674GLN1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59729:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/B5G1P2 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/59729:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A674HUW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:LOC100229710 ^@ http://purl.uniprot.org/uniprot/B5G3N2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59729:TMEM138 ^@ http://purl.uniprot.org/uniprot/B5FZ91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/59729:CCND1 ^@ http://purl.uniprot.org/uniprot/H0Z4M3 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/59729:GNA12 ^@ http://purl.uniprot.org/uniprot/A0A674G7Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/59729:LACC1 ^@ http://purl.uniprot.org/uniprot/H0ZQ31 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/59729:LOC105758723 ^@ http://purl.uniprot.org/uniprot/H0ZDM6 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:CYRIB ^@ http://purl.uniprot.org/uniprot/A0A674HDP9|||http://purl.uniprot.org/uniprot/H0ZQJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/59729:KPNA5 ^@ http://purl.uniprot.org/uniprot/H0ZNW0 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/59729:EMP1 ^@ http://purl.uniprot.org/uniprot/A0A674HBQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/59729:TXN ^@ http://purl.uniprot.org/uniprot/B5G117 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/59729:TSPAN13 ^@ http://purl.uniprot.org/uniprot/B5FY97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:CCN2 ^@ http://purl.uniprot.org/uniprot/H0ZN06 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59729:TK1 ^@ http://purl.uniprot.org/uniprot/H0YYT9 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/59729:LOC100218258 ^@ http://purl.uniprot.org/uniprot/H0ZRL7 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/59729:MYADML2 ^@ http://purl.uniprot.org/uniprot/A0A674GXV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/59729:UNC50 ^@ http://purl.uniprot.org/uniprot/H0ZIU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/59729:HSPB1 ^@ http://purl.uniprot.org/uniprot/H0Z2A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||spindle http://togogenome.org/gene/59729:PEX12 ^@ http://purl.uniprot.org/uniprot/H0Z341 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/59729:IMP4 ^@ http://purl.uniprot.org/uniprot/B5FXR7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59729:ACTR10 ^@ http://purl.uniprot.org/uniprot/A0A674G9H4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/59729:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A674H6E8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/59729:VAPB ^@ http://purl.uniprot.org/uniprot/B5G1M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:IL15 ^@ http://purl.uniprot.org/uniprot/H0YVW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/59729:ATP6V0C ^@ http://purl.uniprot.org/uniprot/B5G238 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/59729:TBCE ^@ http://purl.uniprot.org/uniprot/H0ZJ32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Cytoplasm http://togogenome.org/gene/59729:LOC100225149 ^@ http://purl.uniprot.org/uniprot/H0Z8X7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:HSPB8 ^@ http://purl.uniprot.org/uniprot/H0ZG07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity. http://togogenome.org/gene/59729:RRN3 ^@ http://purl.uniprot.org/uniprot/A0A674HS41 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/59729:LOC100228043 ^@ http://purl.uniprot.org/uniprot/H0Z3W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Secreted http://togogenome.org/gene/59729:CD9 ^@ http://purl.uniprot.org/uniprot/B5FXC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59729:REEP5 ^@ http://purl.uniprot.org/uniprot/B5G1U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/59729:STAR ^@ http://purl.uniprot.org/uniprot/Q6RCE2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/59729:IMPA1 ^@ http://purl.uniprot.org/uniprot/H0ZN52 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/59729:COPS7A ^@ http://purl.uniprot.org/uniprot/B5G2R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:NDUFAF4 ^@ http://purl.uniprot.org/uniprot/B5KFM8 ^@ Similarity|||Subunit ^@ Belongs to the NDUFAF4 family.|||Binds calmodulin. Interacts with NDUFAF3. http://togogenome.org/gene/59729:SNRPG ^@ http://purl.uniprot.org/uniprot/B5FZB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/59729:LOC105758848 ^@ http://purl.uniprot.org/uniprot/A0A674GJT7 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:PACC1 ^@ http://purl.uniprot.org/uniprot/A0A674GZW6|||http://purl.uniprot.org/uniprot/H0YXX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:BRMS1L ^@ http://purl.uniprot.org/uniprot/H0ZP36 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:LOC100220068 ^@ http://purl.uniprot.org/uniprot/H0ZA73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/59729:ORC6 ^@ http://purl.uniprot.org/uniprot/B5G1W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/59729:MED10 ^@ http://purl.uniprot.org/uniprot/B5FYB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59729:SRD5A2 ^@ http://purl.uniprot.org/uniprot/H0ZDP3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Microsome membrane http://togogenome.org/gene/59729:BDNF ^@ http://purl.uniprot.org/uniprot/A0A674GHV5|||http://purl.uniprot.org/uniprot/Q4JHT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.|||Secreted http://togogenome.org/gene/59729:PDE6B ^@ http://purl.uniprot.org/uniprot/H0YPK4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59729:NDUFS7 ^@ http://purl.uniprot.org/uniprot/B5G1Z9 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/59729:PSMA2 ^@ http://purl.uniprot.org/uniprot/B5G154 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/59729:UCHL3 ^@ http://purl.uniprot.org/uniprot/H0ZQL5 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/59729:ALG2 ^@ http://purl.uniprot.org/uniprot/B5FYC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/59729:CSTB ^@ http://purl.uniprot.org/uniprot/B5G158 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/59729:TUSC3 ^@ http://purl.uniprot.org/uniprot/B5G2V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:MTFR1 ^@ http://purl.uniprot.org/uniprot/A0A674GNV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/59729:IER3IP1 ^@ http://purl.uniprot.org/uniprot/B5FXY2 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/59729:TOP2B ^@ http://purl.uniprot.org/uniprot/A0A674HNR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/59729:MTX2 ^@ http://purl.uniprot.org/uniprot/B5FXM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59729:CALHM5 ^@ http://purl.uniprot.org/uniprot/H0ZNX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/59729:RHAG ^@ http://purl.uniprot.org/uniprot/H0ZSQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/59729:FLCN ^@ http://purl.uniprot.org/uniprot/A0A674GGP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/59729:SOAT1 ^@ http://purl.uniprot.org/uniprot/A0A674GMA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/H0ZHM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/59729:CAST ^@ http://purl.uniprot.org/uniprot/A0A674GF67 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/59729:LOC751972 ^@ http://purl.uniprot.org/uniprot/Q9IA35 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/59729:CYFIP1 ^@ http://purl.uniprot.org/uniprot/A0A674GP98 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/59729:TAF13 ^@ http://purl.uniprot.org/uniprot/B5FYP3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ENY2 ^@ http://purl.uniprot.org/uniprot/B5FZ63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates in a subcomplex of SAGA called the DUB module (deubiquitination module) (By similarity).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).|||nucleoplasm http://togogenome.org/gene/59729:SCAMP4 ^@ http://purl.uniprot.org/uniprot/A0A674H7J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/59729:KIF20A ^@ http://purl.uniprot.org/uniprot/H0ZTX3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59729:MC4R ^@ http://purl.uniprot.org/uniprot/A0A674GHA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/59729:RNF146 ^@ http://purl.uniprot.org/uniprot/H0ZNF0 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/59729:SLC34A2 ^@ http://purl.uniprot.org/uniprot/H0ZG96 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:CNKSR2 ^@ http://purl.uniprot.org/uniprot/H0ZAS6 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/59729:OAZ2 ^@ http://purl.uniprot.org/uniprot/H0Z2Q7 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/59729:CCKAR ^@ http://purl.uniprot.org/uniprot/H0ZG11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/59729:PPP1R14C ^@ http://purl.uniprot.org/uniprot/A0A674GQB4 ^@ Similarity ^@ Belongs to the PP1 inhibitor family. http://togogenome.org/gene/59729:SLC17A8 ^@ http://purl.uniprot.org/uniprot/H0ZF76 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:FBLN5 ^@ http://purl.uniprot.org/uniprot/H0ZQN6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:LTV1 ^@ http://purl.uniprot.org/uniprot/A0A674H4M8 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/59729:ATP5PO ^@ http://purl.uniprot.org/uniprot/B5G4C5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:ZGPAT ^@ http://purl.uniprot.org/uniprot/A0A674H806 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:RSAD2 ^@ http://purl.uniprot.org/uniprot/H0ZRY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RSAD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:KEG28_p07 ^@ http://purl.uniprot.org/uniprot/Q27GW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/59729:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A674GY84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/59729:PTPN21 ^@ http://purl.uniprot.org/uniprot/H0ZQ90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/59729:SDC1 ^@ http://purl.uniprot.org/uniprot/H0ZSE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/59729:RIMKLB ^@ http://purl.uniprot.org/uniprot/H0ZSA7 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/59729:PSENEN ^@ http://purl.uniprot.org/uniprot/B5KFN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/59729:KEG28_p10 ^@ http://purl.uniprot.org/uniprot/Q27GW5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:SHOX ^@ http://purl.uniprot.org/uniprot/H0ZKA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:RPL27A ^@ http://purl.uniprot.org/uniprot/B5G0Y3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/59729:PDHB ^@ http://purl.uniprot.org/uniprot/B5G1H2 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/59729:MMP2 ^@ http://purl.uniprot.org/uniprot/H0ZAJ9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/59729:NDUFA2 ^@ http://purl.uniprot.org/uniprot/B5FZL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:TSPAN8 ^@ http://purl.uniprot.org/uniprot/H0Z9X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59729:GABRA1 ^@ http://purl.uniprot.org/uniprot/H0YT92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59729:ODC1 ^@ http://purl.uniprot.org/uniprot/H0ZS38 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/59729:YIPF6 ^@ http://purl.uniprot.org/uniprot/B5FZB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:CBWD1 ^@ http://purl.uniprot.org/uniprot/H0Z5F1 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/59729:SNRPD3 ^@ http://purl.uniprot.org/uniprot/B5G3H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/59729:EIF4E ^@ http://purl.uniprot.org/uniprot/B5FX97 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/59729:IDH3A ^@ http://purl.uniprot.org/uniprot/B5FZM6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/59729:COPB1 ^@ http://purl.uniprot.org/uniprot/A0A674GIG4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/59729:DLK2 ^@ http://purl.uniprot.org/uniprot/A0A674H6C9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:GRB2 ^@ http://purl.uniprot.org/uniprot/B5FZR7 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/59729:LOC105758694 ^@ http://purl.uniprot.org/uniprot/A0A674GDY1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59729:CUL4B ^@ http://purl.uniprot.org/uniprot/H0YZC4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/59729:MC5R ^@ http://purl.uniprot.org/uniprot/A0A674H3T8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. http://togogenome.org/gene/59729:HTATSF1 ^@ http://purl.uniprot.org/uniprot/A0A674GGT0 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/59729:TPRA1 ^@ http://purl.uniprot.org/uniprot/A0A674H332 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/59729:POLB ^@ http://purl.uniprot.org/uniprot/H0Z558 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/59729:TEC ^@ http://purl.uniprot.org/uniprot/H0ZCS7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59729:MAPK8IP1 ^@ http://purl.uniprot.org/uniprot/H0ZKC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JIP scaffold family.|||Cytoplasm http://togogenome.org/gene/59729:BLOC1S5 ^@ http://purl.uniprot.org/uniprot/A0A674GQ93 ^@ Function|||Similarity ^@ Belongs to the BLOC1S5 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). http://togogenome.org/gene/59729:RGR ^@ http://purl.uniprot.org/uniprot/H0Z6G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:PPFIBP1 ^@ http://purl.uniprot.org/uniprot/A0A674HJ85 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/59729:KEG28_p04 ^@ http://purl.uniprot.org/uniprot/Q27GV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59729:PRKX ^@ http://purl.uniprot.org/uniprot/H0ZE73 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:TAF1B ^@ http://purl.uniprot.org/uniprot/H0ZS29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||nucleolus http://togogenome.org/gene/59729:IFT43 ^@ http://purl.uniprot.org/uniprot/B5G1P1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.|||Belongs to the IFT43 family.|||Component of the IFT complex A (IFT-A) complex.|||cilium|||cytoskeleton http://togogenome.org/gene/59729:ARPC3 ^@ http://purl.uniprot.org/uniprot/B5FZ67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/59729:MTX3 ^@ http://purl.uniprot.org/uniprot/H0YZJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59729:IMPACT ^@ http://purl.uniprot.org/uniprot/H0ZJW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/59729:NDST2 ^@ http://purl.uniprot.org/uniprot/A0A674GC42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/59729:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/H0Z8C1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/59729:LOC100190440 ^@ http://purl.uniprot.org/uniprot/B5G293 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/59729:MRPL12 ^@ http://purl.uniprot.org/uniprot/B5FZ07 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/59729:ALYREF ^@ http://purl.uniprot.org/uniprot/B5FXN8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.|||Belongs to the ALYREF family.|||Cytoplasm|||Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability (By similarity).|||Homomultimer. Is part of several complexes involved in mRNA processing and export. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have a dynamic structure involving ATP-dependent remodeling (By similarity).|||Nucleus|||Nucleus speckle http://togogenome.org/gene/59729:KCNA10 ^@ http://purl.uniprot.org/uniprot/H0YRH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:NEIL2 ^@ http://purl.uniprot.org/uniprot/H0ZSU3 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/59729:CDH20 ^@ http://purl.uniprot.org/uniprot/H0YUS1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/59729:PPP1CC ^@ http://purl.uniprot.org/uniprot/B5KFI8 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/59729:UBE4A ^@ http://purl.uniprot.org/uniprot/H0YPA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/59729:BET1 ^@ http://purl.uniprot.org/uniprot/A0A674H1G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:PSMC2 ^@ http://purl.uniprot.org/uniprot/B5G2S7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/59729:RPL14 ^@ http://purl.uniprot.org/uniprot/B5FXD9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/59729:TMEM80 ^@ http://purl.uniprot.org/uniprot/B5FYL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:TOMM20 ^@ http://purl.uniprot.org/uniprot/B5FY80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59729:NMB ^@ http://purl.uniprot.org/uniprot/H0Z347 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted http://togogenome.org/gene/59729:DTX3L ^@ http://purl.uniprot.org/uniprot/H0Z099 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/59729:ARPC2 ^@ http://purl.uniprot.org/uniprot/B5G418 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/59729:RPF1 ^@ http://purl.uniprot.org/uniprot/H0Z878 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59729:PTAFR ^@ http://purl.uniprot.org/uniprot/A0A674H035 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/59729:DLL4 ^@ http://purl.uniprot.org/uniprot/H0ZKJ0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/59729:BMP5 ^@ http://purl.uniprot.org/uniprot/H0ZRG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/59729:LOC100230278 ^@ http://purl.uniprot.org/uniprot/A0A674GYD0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59729:GOLM2 ^@ http://purl.uniprot.org/uniprot/H0ZI19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/59729:LOC100222067 ^@ http://purl.uniprot.org/uniprot/H0ZRV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:RPL7A ^@ http://purl.uniprot.org/uniprot/B5FYM8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/59729:GPM6A ^@ http://purl.uniprot.org/uniprot/H0Z7K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/59729:DHDDS ^@ http://purl.uniprot.org/uniprot/H0YRZ9 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/59729:MICOS10 ^@ http://purl.uniprot.org/uniprot/B5G172 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:OXTR ^@ http://purl.uniprot.org/uniprot/A0A674GUK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:CREB1 ^@ http://purl.uniprot.org/uniprot/Q9W618 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:PLAGL1 ^@ http://purl.uniprot.org/uniprot/A0A674H1C7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:SLC44A1 ^@ http://purl.uniprot.org/uniprot/A0A674H469 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/59729:NUDT21 ^@ http://purl.uniprot.org/uniprot/B5G2F4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/59729:EGR1 ^@ http://purl.uniprot.org/uniprot/A0MWD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/59729:SNRPC ^@ http://purl.uniprot.org/uniprot/H0YU62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/59729:ATP8A1 ^@ http://purl.uniprot.org/uniprot/A0A674GH95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/59729:TMEM63C ^@ http://purl.uniprot.org/uniprot/A0A674GHT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/59729:YBEY ^@ http://purl.uniprot.org/uniprot/H0YZ61 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/59729:SOD2 ^@ http://purl.uniprot.org/uniprot/B5G0D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/59729:CD44 ^@ http://purl.uniprot.org/uniprot/A0A674H0E7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/59729:LITAF ^@ http://purl.uniprot.org/uniprot/A0A674H5B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/59729:A1CF ^@ http://purl.uniprot.org/uniprot/H0Z3W9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59729:ANAPC13 ^@ http://purl.uniprot.org/uniprot/B5G2E3 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/59729:SLC1A3 ^@ http://purl.uniprot.org/uniprot/H0YUY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/59729:RPS27L ^@ http://purl.uniprot.org/uniprot/B5FYJ9 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/59729:SEC22B ^@ http://purl.uniprot.org/uniprot/A0A674G831 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/59729:EEF1A2 ^@ http://purl.uniprot.org/uniprot/H0ZAP0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/59729:RPS18 ^@ http://purl.uniprot.org/uniprot/B5FXB5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/59729:CORT ^@ http://purl.uniprot.org/uniprot/B5FXX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/59729:GALNT14 ^@ http://purl.uniprot.org/uniprot/H0Z2K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:ACTC1 ^@ http://purl.uniprot.org/uniprot/H0ZNH2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/59729:TRIM32 ^@ http://purl.uniprot.org/uniprot/H0YYP5 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/59729:DTD1 ^@ http://purl.uniprot.org/uniprot/B5G2B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/59729:SYS1 ^@ http://purl.uniprot.org/uniprot/B5FX68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/59729:TENT5D ^@ http://purl.uniprot.org/uniprot/H0ZXU6 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/59729:NFU1 ^@ http://purl.uniprot.org/uniprot/B5FZQ4 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/59729:APOH ^@ http://purl.uniprot.org/uniprot/H0Z1D4 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59729:ADRM1 ^@ http://purl.uniprot.org/uniprot/B5G2V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:LOC100222320 ^@ http://purl.uniprot.org/uniprot/H1A2P8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/59729:CCR4 ^@ http://purl.uniprot.org/uniprot/H1A5S3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:AP1S3 ^@ http://purl.uniprot.org/uniprot/H0ZC35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/59729:POLR3F ^@ http://purl.uniprot.org/uniprot/H0Z623 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/59729:MED30 ^@ http://purl.uniprot.org/uniprot/B5FY99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/59729:CALB2 ^@ http://purl.uniprot.org/uniprot/B5FYS1 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/59729:RBM22 ^@ http://purl.uniprot.org/uniprot/H0YRG9 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/59729:NUS1 ^@ http://purl.uniprot.org/uniprot/B5FXN7 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/59729:ARL1 ^@ http://purl.uniprot.org/uniprot/B5FY69 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/59729:MITF ^@ http://purl.uniprot.org/uniprot/H0ZHV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/59729:ACAA1 ^@ http://purl.uniprot.org/uniprot/H0YQ62 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/59729:MRPL42 ^@ http://purl.uniprot.org/uniprot/B5FXK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/59729:PAQR3 ^@ http://purl.uniprot.org/uniprot/H0YTF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/59729:HIGD2A ^@ http://purl.uniprot.org/uniprot/B5FY22 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/59729:P2RY8 ^@ http://purl.uniprot.org/uniprot/H0ZKD3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:LOC100225627 ^@ http://purl.uniprot.org/uniprot/F2Y9D5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59729:GLDC ^@ http://purl.uniprot.org/uniprot/H0Z3D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/59729:SLC12A2 ^@ http://purl.uniprot.org/uniprot/H0Z8B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/59729:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A674HN74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/59729:ARPC4 ^@ http://purl.uniprot.org/uniprot/B5FYW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/59729:FERMT1 ^@ http://purl.uniprot.org/uniprot/A0A674GWM6 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/59729:MAP1LC3B ^@ http://purl.uniprot.org/uniprot/B5G485 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/59729:NPVF ^@ http://purl.uniprot.org/uniprot/D3KX45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/59729:POLR2F ^@ http://purl.uniprot.org/uniprot/B5G123 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/59729:COPS8 ^@ http://purl.uniprot.org/uniprot/A0A674GLB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:ATG12 ^@ http://purl.uniprot.org/uniprot/B5FX55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/59729:LOC105759190 ^@ http://purl.uniprot.org/uniprot/H0YVE4 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/59729:FAM131B ^@ http://purl.uniprot.org/uniprot/A0A674GDT3 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/59729:BCL2 ^@ http://purl.uniprot.org/uniprot/A0A674GNG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion outer membrane|||Nucleus membrane http://togogenome.org/gene/59729:MFSD10 ^@ http://purl.uniprot.org/uniprot/H0ZJM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:FOXP4 ^@ http://purl.uniprot.org/uniprot/K4EN27 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:PPIH ^@ http://purl.uniprot.org/uniprot/H1A3T3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59729:KCNJ6 ^@ http://purl.uniprot.org/uniprot/H0Z3J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/59729:GATA4 ^@ http://purl.uniprot.org/uniprot/A0A674GCP6|||http://purl.uniprot.org/uniprot/A0A674HPU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:MND1 ^@ http://purl.uniprot.org/uniprot/H0Z3X5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/59729:TMEM87A ^@ http://purl.uniprot.org/uniprot/H0ZLE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:VPS35L ^@ http://purl.uniprot.org/uniprot/A0A674H4W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS35L family.|||Endosome http://togogenome.org/gene/59729:YWHAH ^@ http://purl.uniprot.org/uniprot/B5G4A6 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/59729:LYRM1 ^@ http://purl.uniprot.org/uniprot/B5FYC7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/59729:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A674HCH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/59729:LOC100226705 ^@ http://purl.uniprot.org/uniprot/H0YSF2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59729:LMNB2 ^@ http://purl.uniprot.org/uniprot/H0YP57 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59729:EFNB2 ^@ http://purl.uniprot.org/uniprot/A0A674GMS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:EIF4E2 ^@ http://purl.uniprot.org/uniprot/H0ZI64 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/59729:SMCO4 ^@ http://purl.uniprot.org/uniprot/B5FXC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMCO4 family.|||Membrane http://togogenome.org/gene/59729:PPP1CA ^@ http://purl.uniprot.org/uniprot/B5FXE9 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily. http://togogenome.org/gene/59729:UFD1 ^@ http://purl.uniprot.org/uniprot/H0ZDX0 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/59729:MINDY2 ^@ http://purl.uniprot.org/uniprot/H0Z6P1 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/59729:LOC100218405 ^@ http://purl.uniprot.org/uniprot/D8FT03 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/59729:XPO1 ^@ http://purl.uniprot.org/uniprot/H0Z824 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/59729:LOC100224950 ^@ http://purl.uniprot.org/uniprot/A0A674GI06 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59729:PIGU ^@ http://purl.uniprot.org/uniprot/H0YYQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:DNASE2B ^@ http://purl.uniprot.org/uniprot/H0Z889 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/59729:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/H0ZPL7 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/59729:RPS29 ^@ http://purl.uniprot.org/uniprot/B5FZD5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/59729:LOC100190380 ^@ http://purl.uniprot.org/uniprot/Q8AYA7 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/59729:SLC18A2 ^@ http://purl.uniprot.org/uniprot/H0ZLD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:LOC105759110 ^@ http://purl.uniprot.org/uniprot/A0A674GLD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/59729:CYP19A1 ^@ http://purl.uniprot.org/uniprot/Q92112 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Catalyzes the formation of aromatic C18 estrogens from C19 androgens.|||Membrane http://togogenome.org/gene/59729:GPATCH11 ^@ http://purl.uniprot.org/uniprot/H0ZEN2 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/59729:CCN4 ^@ http://purl.uniprot.org/uniprot/H0ZQQ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59729:B3GALT2 ^@ http://purl.uniprot.org/uniprot/A0A674HQQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:PTGR2 ^@ http://purl.uniprot.org/uniprot/B5FYK7 ^@ Similarity ^@ Belongs to the NADP-dependent oxidoreductase L4BD family. http://togogenome.org/gene/59729:PRRC1 ^@ http://purl.uniprot.org/uniprot/A0A674GUP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/59729:RPS8 ^@ http://purl.uniprot.org/uniprot/B5FZC2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/59729:STAG2 ^@ http://purl.uniprot.org/uniprot/H0Z009 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/59729:OSBPL5 ^@ http://purl.uniprot.org/uniprot/A0A674GLX7 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59729:PYCR1 ^@ http://purl.uniprot.org/uniprot/B5FZ50|||http://purl.uniprot.org/uniprot/H0YZE9 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/59729:SSBP1 ^@ http://purl.uniprot.org/uniprot/B5FZJ9 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/59729:UBE2F ^@ http://purl.uniprot.org/uniprot/A0A674H8W5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59729:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A674GFR2|||http://purl.uniprot.org/uniprot/A0A674HL18 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:NAXE ^@ http://purl.uniprot.org/uniprot/B5G185 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||Secreted http://togogenome.org/gene/59729:LOC105759120 ^@ http://purl.uniprot.org/uniprot/H1A4M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/59729:MAB21L1 ^@ http://purl.uniprot.org/uniprot/H0ZNN6 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/59729:C30H19orf53 ^@ http://purl.uniprot.org/uniprot/B5FXD2 ^@ Similarity ^@ Belongs to the UPF0390 family. http://togogenome.org/gene/59729:SMARCB1 ^@ http://purl.uniprot.org/uniprot/H0ZJ65 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF5 family.|||Component of the multiprotein chromatin-remodeling complexes SWI/SNF.|||Nucleus http://togogenome.org/gene/59729:CYP11A1 ^@ http://purl.uniprot.org/uniprot/Q6GVK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:PRR5 ^@ http://purl.uniprot.org/uniprot/H0ZNE0 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/59729:LOC100228221 ^@ http://purl.uniprot.org/uniprot/A0A674HFR6 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/59729:CCNG2 ^@ http://purl.uniprot.org/uniprot/H0YU20 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/59729:GRPR ^@ http://purl.uniprot.org/uniprot/H0ZC68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:NDUFA6 ^@ http://purl.uniprot.org/uniprot/B5G1U3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:NCALD ^@ http://purl.uniprot.org/uniprot/P62759 ^@ Function|||Similarity ^@ Belongs to the recoverin family.|||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). http://togogenome.org/gene/59729:DLC1 ^@ http://purl.uniprot.org/uniprot/H0ZAI1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59729:DSTN ^@ http://purl.uniprot.org/uniprot/B5G1W5 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/59729:FABP3 ^@ http://purl.uniprot.org/uniprot/B5FX90 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59729:PRKAA1 ^@ http://purl.uniprot.org/uniprot/A0A674HEW4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/59729:SGMS2 ^@ http://purl.uniprot.org/uniprot/H0Z0K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/59729:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/B5FXH5 ^@ Caution|||Similarity ^@ Belongs to the ATPase C chain family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A674GNK1 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/59729:KEG28_p02 ^@ http://purl.uniprot.org/uniprot/Q6RUP7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:CD40LG ^@ http://purl.uniprot.org/uniprot/H0YV53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface http://togogenome.org/gene/59729:LPAR4 ^@ http://purl.uniprot.org/uniprot/H0YWI6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:GNG5 ^@ http://purl.uniprot.org/uniprot/A0A674GVY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/59729:EPC2 ^@ http://purl.uniprot.org/uniprot/H0ZNY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/59729:TMEM177 ^@ http://purl.uniprot.org/uniprot/H0Z2R3 ^@ Function|||Similarity ^@ Belongs to the TMEM177 family.|||Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. http://togogenome.org/gene/59729:NSG1 ^@ http://purl.uniprot.org/uniprot/B5G0R0 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/59729:MRPL33 ^@ http://purl.uniprot.org/uniprot/B5FZ89 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/59729:RXRG ^@ http://purl.uniprot.org/uniprot/F2Y9D4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/59729:LOC100229276 ^@ http://purl.uniprot.org/uniprot/B5FYW5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:UTS2 ^@ http://purl.uniprot.org/uniprot/A0A385LVL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/59729:LOC100220507 ^@ http://purl.uniprot.org/uniprot/H0ZDG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59729:NFS1 ^@ http://purl.uniprot.org/uniprot/H0YXW1 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/59729:TMEM17 ^@ http://purl.uniprot.org/uniprot/B5FXH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:NDUFS6 ^@ http://purl.uniprot.org/uniprot/B5FZT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS6 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:SPCS1 ^@ http://purl.uniprot.org/uniprot/B5KFM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:PPIL3 ^@ http://purl.uniprot.org/uniprot/H0ZJF1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59729:RPL7 ^@ http://purl.uniprot.org/uniprot/B5G3W2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/59729:PPIP5K1 ^@ http://purl.uniprot.org/uniprot/A0A674HEL6|||http://purl.uniprot.org/uniprot/A0A674HJQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/59729:ATP6V1A ^@ http://purl.uniprot.org/uniprot/A0A674GTZ4 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/59729:MCTS1 ^@ http://purl.uniprot.org/uniprot/B5FXH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/59729:KCTD20 ^@ http://purl.uniprot.org/uniprot/A0A674G8X3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59729:LHFPL5 ^@ http://purl.uniprot.org/uniprot/B5FXX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:H3F3A ^@ http://purl.uniprot.org/uniprot/B5FZ57 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:LOC100225836 ^@ http://purl.uniprot.org/uniprot/A0A674HFR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 7B2 family.|||Secreted http://togogenome.org/gene/59729:ISCA2 ^@ http://purl.uniprot.org/uniprot/B5FY25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/59729:RPS21 ^@ http://purl.uniprot.org/uniprot/B5FYM5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/59729:NOP16 ^@ http://purl.uniprot.org/uniprot/H0YQK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/59729:CENPS ^@ http://purl.uniprot.org/uniprot/B5FYL8 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/59729:HBAD ^@ http://purl.uniprot.org/uniprot/B5FXM1 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59729:MMUT ^@ http://purl.uniprot.org/uniprot/A0A674H6C5 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/59729:RPL24 ^@ http://purl.uniprot.org/uniprot/B5FYC4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/59729:EIF2S1 ^@ http://purl.uniprot.org/uniprot/B5FYU5|||http://purl.uniprot.org/uniprot/H0ZMS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/59729:WASHC5 ^@ http://purl.uniprot.org/uniprot/H0ZQI1 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/59729:VPS26C ^@ http://purl.uniprot.org/uniprot/A0A674HU40 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/59729:SRP19 ^@ http://purl.uniprot.org/uniprot/B5FY28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/59729:NR1H4 ^@ http://purl.uniprot.org/uniprot/H0ZFA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.|||Nucleus http://togogenome.org/gene/59729:SFT2D1 ^@ http://purl.uniprot.org/uniprot/B5FY39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/59729:LOC100224495 ^@ http://purl.uniprot.org/uniprot/H0Z5A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:CAPN9 ^@ http://purl.uniprot.org/uniprot/H0ZI51 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/59729:MRPS25 ^@ http://purl.uniprot.org/uniprot/B5G277 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/59729:UBE2A ^@ http://purl.uniprot.org/uniprot/H0YYS2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59729:HAAO ^@ http://purl.uniprot.org/uniprot/H0YZ81 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/59729:CD40 ^@ http://purl.uniprot.org/uniprot/H0Z5Z9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:CAMK2N1 ^@ http://purl.uniprot.org/uniprot/B5G2Q7 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/59729:AQP3 ^@ http://purl.uniprot.org/uniprot/H0YTV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:BTF3 ^@ http://purl.uniprot.org/uniprot/B5FXB9 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/59729:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A674H3K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59729:GNG12 ^@ http://purl.uniprot.org/uniprot/B5KFK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/59729:LOC100218414 ^@ http://purl.uniprot.org/uniprot/H0YYI1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:MSTN ^@ http://purl.uniprot.org/uniprot/H0ZKS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/59729:CNOT10 ^@ http://purl.uniprot.org/uniprot/H0Z002 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:DIABLO ^@ http://purl.uniprot.org/uniprot/B5FY41 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/59729:HOXA9 ^@ http://purl.uniprot.org/uniprot/H0YXI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/59729:SEPHS1 ^@ http://purl.uniprot.org/uniprot/A0A674HNH9 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/59729:FAM168A ^@ http://purl.uniprot.org/uniprot/B5FX98 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/59729:FLNB ^@ http://purl.uniprot.org/uniprot/H0ZAR1 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/59729:LOC100232533 ^@ http://purl.uniprot.org/uniprot/A0A674HCE2 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/59729:SGCG ^@ http://purl.uniprot.org/uniprot/A0A674GYI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/59729:CDK3 ^@ http://purl.uniprot.org/uniprot/H0ZCU2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:SEC61G ^@ http://purl.uniprot.org/uniprot/A0A674H217 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:BCLAF1 ^@ http://purl.uniprot.org/uniprot/A0A674HFV1 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/59729:SAP18 ^@ http://purl.uniprot.org/uniprot/B5G450 ^@ Function|||Similarity ^@ Belongs to the SAP18 family.|||Involved in the tethering of the SIN3 complex to core histone proteins. http://togogenome.org/gene/59729:EMC4 ^@ http://purl.uniprot.org/uniprot/B5G207 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:PTH ^@ http://purl.uniprot.org/uniprot/H1A031 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.|||Secreted http://togogenome.org/gene/59729:SUMO1 ^@ http://purl.uniprot.org/uniprot/B5FZ54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/59729:CMC2 ^@ http://purl.uniprot.org/uniprot/B5FXK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||May be involved in cytochrome c oxidase biogenesis.|||Mitochondrion http://togogenome.org/gene/59729:VEGFD ^@ http://purl.uniprot.org/uniprot/H0ZCM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/59729:CHCHD4 ^@ http://purl.uniprot.org/uniprot/H0ZD63 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/59729:RPL8 ^@ http://purl.uniprot.org/uniprot/B5KFK9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/59729:NKX2-5 ^@ http://purl.uniprot.org/uniprot/A0A674GFR9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:KIN ^@ http://purl.uniprot.org/uniprot/H0YV65 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/59729:RPL36 ^@ http://purl.uniprot.org/uniprot/B5FXV8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/59729:LOC100224389 ^@ http://purl.uniprot.org/uniprot/H0Z839 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/59729:STEEP1 ^@ http://purl.uniprot.org/uniprot/B5FZ01 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/59729:AKR1A1 ^@ http://purl.uniprot.org/uniprot/H0ZCF8 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/59729:LOC100221073 ^@ http://purl.uniprot.org/uniprot/H0ZSP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59729:GAP43 ^@ http://purl.uniprot.org/uniprot/A0A674HU46 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Cell membrane|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/59729:PRKAR2A ^@ http://purl.uniprot.org/uniprot/H0ZFR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:RPL34 ^@ http://purl.uniprot.org/uniprot/B5FY45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/59729:HSDL2 ^@ http://purl.uniprot.org/uniprot/H0YSN7 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/59729:PSMB7 ^@ http://purl.uniprot.org/uniprot/H0Z9V3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:MRPS27 ^@ http://purl.uniprot.org/uniprot/A0A674H958 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/59729:FBXO9 ^@ http://purl.uniprot.org/uniprot/H0ZRL1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9).|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling. http://togogenome.org/gene/59729:MRPL23 ^@ http://purl.uniprot.org/uniprot/B5G200 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/59729:TP53INP1 ^@ http://purl.uniprot.org/uniprot/A0A674H047 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/59729:SLC35F4 ^@ http://purl.uniprot.org/uniprot/H0ZS41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/59729:TMEM178B ^@ http://purl.uniprot.org/uniprot/A0A674HJA1 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/59729:MBP ^@ http://purl.uniprot.org/uniprot/B5G2D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin basic protein family.|||Myelin membrane http://togogenome.org/gene/59729:RPS17 ^@ http://purl.uniprot.org/uniprot/B5FYG2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/59729:ZNF503 ^@ http://purl.uniprot.org/uniprot/H0Z837 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/59729:TMEM41A ^@ http://purl.uniprot.org/uniprot/B5G1B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/59729:MLF2 ^@ http://purl.uniprot.org/uniprot/B5G497 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/59729:PDE6H ^@ http://purl.uniprot.org/uniprot/A0A674H0X6 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/59729:QRFP ^@ http://purl.uniprot.org/uniprot/F5HPR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RFamide neuropeptide family.|||Secreted http://togogenome.org/gene/59729:ATP6V1F ^@ http://purl.uniprot.org/uniprot/B5G4A4 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/59729:CAVIN4 ^@ http://purl.uniprot.org/uniprot/A0A674H1D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/59729:ATAD1 ^@ http://purl.uniprot.org/uniprot/A0A674HLB2 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/59729:F2 ^@ http://purl.uniprot.org/uniprot/H0ZJZ8 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/59729:OPRL1 ^@ http://purl.uniprot.org/uniprot/A0A674H9F1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/59729:SNX20 ^@ http://purl.uniprot.org/uniprot/A0A674GBN1 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Membrane http://togogenome.org/gene/59729:GABBR2 ^@ http://purl.uniprot.org/uniprot/A0A674HEN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:WNT8A ^@ http://purl.uniprot.org/uniprot/H0YSE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59729:PNPLA4 ^@ http://purl.uniprot.org/uniprot/H0ZE01 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:FOXP1 ^@ http://purl.uniprot.org/uniprot/Q6QBA1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:RPS6KA2 ^@ http://purl.uniprot.org/uniprot/A0A674GI56 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/59729:LOC100220427 ^@ http://purl.uniprot.org/uniprot/A0A674GDN7 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/59729:P2RX1 ^@ http://purl.uniprot.org/uniprot/H0ZZW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/59729:ID2 ^@ http://purl.uniprot.org/uniprot/H0ZRZ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:PLLP ^@ http://purl.uniprot.org/uniprot/B5FXB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:LOC100221272 ^@ http://purl.uniprot.org/uniprot/H0YZU7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:COPG1 ^@ http://purl.uniprot.org/uniprot/H0ZBU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/59729:TUBB1 ^@ http://purl.uniprot.org/uniprot/H0ZCG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59729:RMI1 ^@ http://purl.uniprot.org/uniprot/H0YY49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/59729:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A674GW16 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59729:CKS1B ^@ http://purl.uniprot.org/uniprot/B5FXN4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/59729:SLC25A19 ^@ http://purl.uniprot.org/uniprot/A0A674H2J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59729:HSBP1 ^@ http://purl.uniprot.org/uniprot/B5G3X1 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/59729:USE1 ^@ http://purl.uniprot.org/uniprot/A0A674GAT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:ALAS1 ^@ http://purl.uniprot.org/uniprot/H0Z6Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:UBE2B ^@ http://purl.uniprot.org/uniprot/B5FZH8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59729:LHFPL2 ^@ http://purl.uniprot.org/uniprot/H0Z065 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:NR5A1 ^@ http://purl.uniprot.org/uniprot/Q90XC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/59729:DDO ^@ http://purl.uniprot.org/uniprot/H0ZP98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/59729:RTRAF ^@ http://purl.uniprot.org/uniprot/B5G0L3 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/59729:LOC100223260 ^@ http://purl.uniprot.org/uniprot/H0YSG9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A674HCB7|||http://purl.uniprot.org/uniprot/A0A674HN10|||http://purl.uniprot.org/uniprot/A0A674HTF0|||http://purl.uniprot.org/uniprot/B5KFH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/59729:LOC100222345 ^@ http://purl.uniprot.org/uniprot/H0YTH8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/59729:LOC100190722 ^@ http://purl.uniprot.org/uniprot/B5G279 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By similarity).|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A674GIH4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||cytoskeleton http://togogenome.org/gene/59729:ANAPC16 ^@ http://purl.uniprot.org/uniprot/B5G162 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/59729:WSCD1 ^@ http://purl.uniprot.org/uniprot/H0ZF03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WSCD family.|||Golgi apparatus membrane|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/59729:RNASET2 ^@ http://purl.uniprot.org/uniprot/A0A674GW21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Lysosome lumen http://togogenome.org/gene/59729:RAB32 ^@ http://purl.uniprot.org/uniprot/H0ZKG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/59729:NPY5R ^@ http://purl.uniprot.org/uniprot/A0A674GZ65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. http://togogenome.org/gene/59729:JPT1 ^@ http://purl.uniprot.org/uniprot/B5FZM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:UQCR10 ^@ http://purl.uniprot.org/uniprot/B5G1I4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:RPS4X ^@ http://purl.uniprot.org/uniprot/B5FXF0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/59729:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A674GAZ9|||http://purl.uniprot.org/uniprot/H0ZTF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/59729:TAF1 ^@ http://purl.uniprot.org/uniprot/A0A674GS99|||http://purl.uniprot.org/uniprot/H0Z9H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/59729:RAB27A ^@ http://purl.uniprot.org/uniprot/A0A674GLG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/59729:MRPL27 ^@ http://purl.uniprot.org/uniprot/H0ZF26 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/59729:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/H0ZT16 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:TFRC ^@ http://purl.uniprot.org/uniprot/A0A674GYL2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/59729:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A674GWR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/59729:PLP1 ^@ http://purl.uniprot.org/uniprot/P47790 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Cell membrane|||This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. http://togogenome.org/gene/59729:CPSF4 ^@ http://purl.uniprot.org/uniprot/H0ZB24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/59729:PPIL2 ^@ http://purl.uniprot.org/uniprot/H0ZE38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||Nucleus http://togogenome.org/gene/59729:NOL12 ^@ http://purl.uniprot.org/uniprot/B5FY85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/59729:UBE2R2 ^@ http://purl.uniprot.org/uniprot/B5FYL2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59729:CHST1 ^@ http://purl.uniprot.org/uniprot/H0ZKF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/59729:SIAH1 ^@ http://purl.uniprot.org/uniprot/H0ZEA6 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/59729:CDH7 ^@ http://purl.uniprot.org/uniprot/A0A674GM13 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/59729:CCT5 ^@ http://purl.uniprot.org/uniprot/A0A674HGJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/59729:AQP9 ^@ http://purl.uniprot.org/uniprot/H0Z6Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/59729:CFAP36 ^@ http://purl.uniprot.org/uniprot/A0A674H2X7|||http://purl.uniprot.org/uniprot/B5FZW2 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/59729:KEG28_p09 ^@ http://purl.uniprot.org/uniprot/Q27GW4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59729:DKK3 ^@ http://purl.uniprot.org/uniprot/B5FYS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/59729:MED9 ^@ http://purl.uniprot.org/uniprot/B5G4A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59729:GPR52 ^@ http://purl.uniprot.org/uniprot/A0A674HBK4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:IMPDH2 ^@ http://purl.uniprot.org/uniprot/H0ZFC1 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/59729:ALDOB ^@ http://purl.uniprot.org/uniprot/H0YQW0 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/59729:KCNAB2 ^@ http://purl.uniprot.org/uniprot/H0YWU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Membrane|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/59729:LOC100190109 ^@ http://purl.uniprot.org/uniprot/B5FY56 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/59729:HMOX2 ^@ http://purl.uniprot.org/uniprot/B5G0B5 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/59729:NXT2 ^@ http://purl.uniprot.org/uniprot/A0A674GSW1|||http://purl.uniprot.org/uniprot/A0A674HCV4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/59729:SLC12A4 ^@ http://purl.uniprot.org/uniprot/H0ZA22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/59729:RPS19 ^@ http://purl.uniprot.org/uniprot/B5FYU1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/59729:SSR3 ^@ http://purl.uniprot.org/uniprot/B5FYQ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/59729:CEP43 ^@ http://purl.uniprot.org/uniprot/A0A674GU77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||cilium basal body http://togogenome.org/gene/59729:LOC100225375 ^@ http://purl.uniprot.org/uniprot/H0ZG71 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:LOC100189937 ^@ http://purl.uniprot.org/uniprot/B5FX49 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/59729:ITIH2 ^@ http://purl.uniprot.org/uniprot/H0YV61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/59729:LUC7L3 ^@ http://purl.uniprot.org/uniprot/H0ZFZ6 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/59729:SLC20A1 ^@ http://purl.uniprot.org/uniprot/H0YZ07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/59729:GOLM1 ^@ http://purl.uniprot.org/uniprot/H0YXU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/59729:SCNN1A ^@ http://purl.uniprot.org/uniprot/H0ZSY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:LOC100221179 ^@ http://purl.uniprot.org/uniprot/H0ZEI2 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/59729:LLPH ^@ http://purl.uniprot.org/uniprot/A0A674GIQ4 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/59729:MRPS16 ^@ http://purl.uniprot.org/uniprot/B5FXE4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/59729:FGF6 ^@ http://purl.uniprot.org/uniprot/H0ZPU7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59729:KHDRBS3 ^@ http://purl.uniprot.org/uniprot/H0ZQU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KHDRBS family.|||Cytoplasm http://togogenome.org/gene/59729:FAM53A ^@ http://purl.uniprot.org/uniprot/H0ZK48 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/59729:CD81 ^@ http://purl.uniprot.org/uniprot/A0A674GNI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59729:ARL5A ^@ http://purl.uniprot.org/uniprot/A0A674HNE5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/59729:KATNB1 ^@ http://purl.uniprot.org/uniprot/H0Z3A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/59729:PEX13 ^@ http://purl.uniprot.org/uniprot/H0Z8K3 ^@ Similarity ^@ Belongs to the peroxin-13 family. http://togogenome.org/gene/59729:GRPEL1 ^@ http://purl.uniprot.org/uniprot/B5FXT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/59729:ROMO1 ^@ http://purl.uniprot.org/uniprot/B5G4G3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:ELK3 ^@ http://purl.uniprot.org/uniprot/A0A674H9W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59729:AACS ^@ http://purl.uniprot.org/uniprot/H0Z3E1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||cytosol http://togogenome.org/gene/59729:RAN ^@ http://purl.uniprot.org/uniprot/B5FYI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/59729:CRYL1 ^@ http://purl.uniprot.org/uniprot/H0ZM40 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/59729:RPL13A ^@ http://purl.uniprot.org/uniprot/B5G289 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/59729:PRKAB2 ^@ http://purl.uniprot.org/uniprot/A0A674HGM8 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/59729:TDO2 ^@ http://purl.uniprot.org/uniprot/H0Z4T4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:LOC100219971 ^@ http://purl.uniprot.org/uniprot/B5FYJ7 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/59729:CKB ^@ http://purl.uniprot.org/uniprot/B5G2T1 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/59729:NUDT2 ^@ http://purl.uniprot.org/uniprot/A0A674G7I2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/59729:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A674GB06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ATP5PD ^@ http://purl.uniprot.org/uniprot/B5G0V6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:CNTNAP2 ^@ http://purl.uniprot.org/uniprot/D8WUA6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||paranodal septate junction http://togogenome.org/gene/59729:CD93 ^@ http://purl.uniprot.org/uniprot/H0ZAY1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:HOXA10 ^@ http://purl.uniprot.org/uniprot/H0YXI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/59729:MESD ^@ http://purl.uniprot.org/uniprot/A0A674GHE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MESD family.|||Endoplasmic reticulum http://togogenome.org/gene/59729:NUBP2 ^@ http://purl.uniprot.org/uniprot/H0YZE4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. http://togogenome.org/gene/59729:BVES ^@ http://purl.uniprot.org/uniprot/H0ZPQ5 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/59729:SLC25A33 ^@ http://purl.uniprot.org/uniprot/B5FZ80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59729:COG6 ^@ http://purl.uniprot.org/uniprot/A0A674HA20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/59729:RBM8A ^@ http://purl.uniprot.org/uniprot/B5FZD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/59729:SDHA ^@ http://purl.uniprot.org/uniprot/H0ZD78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/59729:HOXA4 ^@ http://purl.uniprot.org/uniprot/H0YXG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/59729:TUBGCP3 ^@ http://purl.uniprot.org/uniprot/H0ZF74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/59729:SLC10A2 ^@ http://purl.uniprot.org/uniprot/H0ZKM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/59729:LOC100219265 ^@ http://purl.uniprot.org/uniprot/H0ZRL9 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/59729:MADCAM1 ^@ http://purl.uniprot.org/uniprot/A0A674H5V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/59729:DDT ^@ http://purl.uniprot.org/uniprot/B5G0R9 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/59729:TMEM170A ^@ http://purl.uniprot.org/uniprot/H0Z7U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/59729:BCCIP ^@ http://purl.uniprot.org/uniprot/B5FXE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||spindle pole http://togogenome.org/gene/59729:GTF2H5 ^@ http://purl.uniprot.org/uniprot/B5G1G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/59729:LRRC8A ^@ http://purl.uniprot.org/uniprot/A0A674GWT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:RHO ^@ http://purl.uniprot.org/uniprot/Q9IA36 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Contains one covalently linked retinal chromophore.|||Membrane http://togogenome.org/gene/59729:MIX23 ^@ http://purl.uniprot.org/uniprot/B5FX56 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/59729:RPL15 ^@ http://purl.uniprot.org/uniprot/B5KFM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Cytoplasm http://togogenome.org/gene/59729:MPC1 ^@ http://purl.uniprot.org/uniprot/B5FZS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:LOC100224677 ^@ http://purl.uniprot.org/uniprot/H0Z0M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/59729:TES ^@ http://purl.uniprot.org/uniprot/H0Z4D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prickle / espinas / testin family.|||focal adhesion http://togogenome.org/gene/59729:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A674H1T0|||http://purl.uniprot.org/uniprot/H0Z906 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/59729:PCID2 ^@ http://purl.uniprot.org/uniprot/H0ZFR6 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/59729:CEP20 ^@ http://purl.uniprot.org/uniprot/A0A674HPP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||cilium basal body http://togogenome.org/gene/59729:LOC100222525 ^@ http://purl.uniprot.org/uniprot/A0A674H2G8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59729:RPL5 ^@ http://purl.uniprot.org/uniprot/B5G1T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/59729:DYNLT1 ^@ http://purl.uniprot.org/uniprot/B5FXR4 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/59729:NDRG1 ^@ http://purl.uniprot.org/uniprot/A0A674G7R1 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/59729:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/A0A674GIJ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle http://togogenome.org/gene/59729:CCDC181 ^@ http://purl.uniprot.org/uniprot/A0A674G8H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton http://togogenome.org/gene/59729:EIF3H ^@ http://purl.uniprot.org/uniprot/B5FY35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/59729:NEU4 ^@ http://purl.uniprot.org/uniprot/A0A674GVS9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/59729:LYRM4 ^@ http://purl.uniprot.org/uniprot/B5FZA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I LYR family.|||Mitochondrion|||Nucleus|||Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. http://togogenome.org/gene/59729:MOCS2 ^@ http://purl.uniprot.org/uniprot/B5FXU9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).|||cytosol http://togogenome.org/gene/59729:RPL35 ^@ http://purl.uniprot.org/uniprot/B5G3L9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/59729:LOC100231339 ^@ http://purl.uniprot.org/uniprot/H0ZBH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/59729:FAM32A ^@ http://purl.uniprot.org/uniprot/B5G3E9 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/59729:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A674HRG8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59729:LOC100221884 ^@ http://purl.uniprot.org/uniprot/A0A674G968 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/59729:PNRC2 ^@ http://purl.uniprot.org/uniprot/A0A674GAY6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:SPIN1 ^@ http://purl.uniprot.org/uniprot/H0YQC0 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/59729:GRB10 ^@ http://purl.uniprot.org/uniprot/H0ZCA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/59729:PIN4 ^@ http://purl.uniprot.org/uniprot/B5KFL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.|||Cytoplasm|||May be involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to DNA (By similarity).|||nucleolus|||spindle http://togogenome.org/gene/59729:EXT2 ^@ http://purl.uniprot.org/uniprot/A0A674HKN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59729:FTH1 ^@ http://purl.uniprot.org/uniprot/B5G472 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/59729:HNRNPDL ^@ http://purl.uniprot.org/uniprot/B5G3X0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59729:RARS2 ^@ http://purl.uniprot.org/uniprot/A0A674H7E7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/59729:HOXD11 ^@ http://purl.uniprot.org/uniprot/H0ZF41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/59729:NQO2 ^@ http://purl.uniprot.org/uniprot/H0YVB6 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/59729:CTNNBIP1 ^@ http://purl.uniprot.org/uniprot/H0YZH4 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/59729:TEX10 ^@ http://purl.uniprot.org/uniprot/H0ZEN1 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/59729:PRPF18 ^@ http://purl.uniprot.org/uniprot/H0YVP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/59729:MAGI3 ^@ http://purl.uniprot.org/uniprot/A0A674GHV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:ARL14 ^@ http://purl.uniprot.org/uniprot/H0ZLM4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/59729:MAPRE1 ^@ http://purl.uniprot.org/uniprot/H0Z7M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/59729:LOC100228204 ^@ http://purl.uniprot.org/uniprot/B5FXC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:SEC24A ^@ http://purl.uniprot.org/uniprot/A0A674GBL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/59729:NRDC ^@ http://purl.uniprot.org/uniprot/H0ZEY8 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/59729:PSMD7 ^@ http://purl.uniprot.org/uniprot/B5KFF3 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/59729:GRIA2 ^@ http://purl.uniprot.org/uniprot/Q76MR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/59729:LOC101233328 ^@ http://purl.uniprot.org/uniprot/H0YW88 ^@ Similarity|||Subcellular Location Annotation ^@ In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/59729:ST8SIA4 ^@ http://purl.uniprot.org/uniprot/H0YRL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59729:TMEM184C ^@ http://purl.uniprot.org/uniprot/H0YWM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:CCDC47 ^@ http://purl.uniprot.org/uniprot/H0YUM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/59729:LPAR6 ^@ http://purl.uniprot.org/uniprot/H0ZPQ3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:RAB4A ^@ http://purl.uniprot.org/uniprot/A0A674H2S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/59729:DIPK1B ^@ http://purl.uniprot.org/uniprot/H0Z6J3 ^@ Similarity ^@ Belongs to the DIPK family. http://togogenome.org/gene/59729:SPRING1 ^@ http://purl.uniprot.org/uniprot/H0ZJ92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:ACVR2B ^@ http://purl.uniprot.org/uniprot/H0YQK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/59729:AR ^@ http://purl.uniprot.org/uniprot/Q2VP86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/59729:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/H0YX80 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/59729:NINJ1 ^@ http://purl.uniprot.org/uniprot/B5FYG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/59729:DICER1 ^@ http://purl.uniprot.org/uniprot/A0A674HKR2 ^@ Function|||Similarity ^@ Belongs to the helicase family. Dicer subfamily.|||Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. http://togogenome.org/gene/59729:GREM1 ^@ http://purl.uniprot.org/uniprot/A0A674G9W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/59729:LOC100225542 ^@ http://purl.uniprot.org/uniprot/A0A674HD88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59729:SLC35B1 ^@ http://purl.uniprot.org/uniprot/B5FZN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/59729:TCEA2 ^@ http://purl.uniprot.org/uniprot/B5G3L7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:GMPR ^@ http://purl.uniprot.org/uniprot/A0A674HNY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/59729:SPON1 ^@ http://purl.uniprot.org/uniprot/A0A674H999 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/59729:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A674H3H0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59729:SNRNP27 ^@ http://purl.uniprot.org/uniprot/B5G3D9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/59729:LOC100227541 ^@ http://purl.uniprot.org/uniprot/H0ZT64 ^@ Function|||Similarity ^@ Belongs to the apovitellenin family.|||Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes. http://togogenome.org/gene/59729:TOR1B ^@ http://purl.uniprot.org/uniprot/A0A674GJD6|||http://purl.uniprot.org/uniprot/H0Z1Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/59729:RANBP10 ^@ http://purl.uniprot.org/uniprot/H0Z4E2 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/59729:CRHR1 ^@ http://purl.uniprot.org/uniprot/A0A2D1CIG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:LOC100190137 ^@ http://purl.uniprot.org/uniprot/B5FYB8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/59729:KCNV1 ^@ http://purl.uniprot.org/uniprot/H0ZPV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/59729:SCD ^@ http://purl.uniprot.org/uniprot/A0A674H3V0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/59729:GABRD ^@ http://purl.uniprot.org/uniprot/H0YXP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59729:MICOS13 ^@ http://purl.uniprot.org/uniprot/H0YQG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:LYN ^@ http://purl.uniprot.org/uniprot/A0A674GFE5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59729:CAPZB ^@ http://purl.uniprot.org/uniprot/B5G462 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/59729:RBM47 ^@ http://purl.uniprot.org/uniprot/H0ZEF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:TIMM10B ^@ http://purl.uniprot.org/uniprot/B5FX88 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/59729:FOXL2 ^@ http://purl.uniprot.org/uniprot/H0Z4D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:MZT1 ^@ http://purl.uniprot.org/uniprot/B5FXZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MOZART1 family.|||Part of the gamma-tubulin complex.|||Required for gamma-tubulin complex recruitment to the centrosome.|||centrosome|||spindle http://togogenome.org/gene/59729:LECT2 ^@ http://purl.uniprot.org/uniprot/H0YSK8 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/59729:CLCN4 ^@ http://purl.uniprot.org/uniprot/H0ZDM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/59729:RPL3 ^@ http://purl.uniprot.org/uniprot/H0ZJ17 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/59729:NUDT12 ^@ http://purl.uniprot.org/uniprot/H0YRR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/59729:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/H0YRB4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59729:NPY1R ^@ http://purl.uniprot.org/uniprot/H0Z5W9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:DCT ^@ http://purl.uniprot.org/uniprot/H0ZLV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane|||Membrane http://togogenome.org/gene/59729:DDOST ^@ http://purl.uniprot.org/uniprot/H0YV45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/59729:MYOD1 ^@ http://purl.uniprot.org/uniprot/H0ZER5 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/59729:LOC100190622 ^@ http://purl.uniprot.org/uniprot/B5FX87 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:C1H12orf57 ^@ http://purl.uniprot.org/uniprot/B5FZA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/59729:MRPL22 ^@ http://purl.uniprot.org/uniprot/B5FXB1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/59729:RBX1 ^@ http://purl.uniprot.org/uniprot/B5FY05 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/59729:LOC100189957 ^@ http://purl.uniprot.org/uniprot/B5FX73 ^@ Similarity ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family. http://togogenome.org/gene/59729:POLR3H ^@ http://purl.uniprot.org/uniprot/H0ZHZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/59729:MOSPD1 ^@ http://purl.uniprot.org/uniprot/B5FYF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:HMGN5 ^@ http://purl.uniprot.org/uniprot/B5FY60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/59729:TMEM35A ^@ http://purl.uniprot.org/uniprot/A0A674GZM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/59729:LOC100190094 ^@ http://purl.uniprot.org/uniprot/B5FY13 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/59729:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A674H7N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/59729:LOC100218088 ^@ http://purl.uniprot.org/uniprot/H0ZAM6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59729:C3H6orf120 ^@ http://purl.uniprot.org/uniprot/A0A674H696 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||Secreted http://togogenome.org/gene/59729:CDK7 ^@ http://purl.uniprot.org/uniprot/H0ZVE4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/59729:SNCB ^@ http://purl.uniprot.org/uniprot/B5FYR9 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/59729:LPGAT1 ^@ http://purl.uniprot.org/uniprot/A0A674G8J3 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59729:SAR1B ^@ http://purl.uniprot.org/uniprot/A0A674HIJ7|||http://purl.uniprot.org/uniprot/B5G3P5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/59729:SF3B5 ^@ http://purl.uniprot.org/uniprot/H0ZKL9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/59729:GHITM ^@ http://purl.uniprot.org/uniprot/B5G2G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/59729:MRPL47 ^@ http://purl.uniprot.org/uniprot/B5FYD9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/59729:SLC25A47 ^@ http://purl.uniprot.org/uniprot/A0A674HUG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59729:PSAT1 ^@ http://purl.uniprot.org/uniprot/H0YYW7 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/59729:SLC30A6 ^@ http://purl.uniprot.org/uniprot/H0ZDW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/59729:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A674HGM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/59729:CELF1 ^@ http://purl.uniprot.org/uniprot/A0A674GZ56|||http://purl.uniprot.org/uniprot/A0A674HQ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:FHL5 ^@ http://purl.uniprot.org/uniprot/H0ZPZ6 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/59729:TSPAN15 ^@ http://purl.uniprot.org/uniprot/H0Z0P9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:LOC100232117 ^@ http://purl.uniprot.org/uniprot/H0ZH38 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59729:SLC25A17 ^@ http://purl.uniprot.org/uniprot/H0ZII0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59729:C1H11orf54 ^@ http://purl.uniprot.org/uniprot/H0ZRI8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/59729:LSM5 ^@ http://purl.uniprot.org/uniprot/B5G480 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/59729:JAK2 ^@ http://purl.uniprot.org/uniprot/H0Z3Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system|||Nucleus http://togogenome.org/gene/59729:EPHX1 ^@ http://purl.uniprot.org/uniprot/H0Z131 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/59729:ANO3 ^@ http://purl.uniprot.org/uniprot/A0A674GNK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A674GQ40 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/59729:LOC100219437 ^@ http://purl.uniprot.org/uniprot/A0A674GW07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/59729:TFAP2D ^@ http://purl.uniprot.org/uniprot/A0A674HP36 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/59729:DDC ^@ http://purl.uniprot.org/uniprot/H0ZC61 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/59729:PKD2L1 ^@ http://purl.uniprot.org/uniprot/A0A674H1E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Cell membrane|||Membrane|||cilium membrane http://togogenome.org/gene/59729:DCN ^@ http://purl.uniprot.org/uniprot/A0A674GNM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/59729:CPLX2 ^@ http://purl.uniprot.org/uniprot/B5G052 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/59729:POLR2E ^@ http://purl.uniprot.org/uniprot/B5FX59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.|||Nucleus http://togogenome.org/gene/59729:KEG28_p06 ^@ http://purl.uniprot.org/uniprot/Q27GW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/59729:CPLX1 ^@ http://purl.uniprot.org/uniprot/B5FXE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/59729:UTP25 ^@ http://purl.uniprot.org/uniprot/H0YYG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/59729:CACNG5 ^@ http://purl.uniprot.org/uniprot/A0A674GRG1 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/59729:HSPA2 ^@ http://purl.uniprot.org/uniprot/H0ZRS0 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/59729:NME2 ^@ http://purl.uniprot.org/uniprot/B5G0H9 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/59729:CNIH1 ^@ http://purl.uniprot.org/uniprot/B5FX71|||http://purl.uniprot.org/uniprot/H0ZS87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/59729:TUBB4B ^@ http://purl.uniprot.org/uniprot/B5G4G7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59729:MRPL20 ^@ http://purl.uniprot.org/uniprot/B5G0D8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family. http://togogenome.org/gene/59729:NUP35 ^@ http://purl.uniprot.org/uniprot/B5FXW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/59729:LOC100231060 ^@ http://purl.uniprot.org/uniprot/H0ZGA9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:KLHL40 ^@ http://purl.uniprot.org/uniprot/H0YPS4 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/59729:ATP5MG ^@ http://purl.uniprot.org/uniprot/B5G3Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/59729:LOC105758846 ^@ http://purl.uniprot.org/uniprot/A0A674H6Y7 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:RPLP1 ^@ http://purl.uniprot.org/uniprot/B5FYY2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/59729:LIN28B ^@ http://purl.uniprot.org/uniprot/A0A674GMH5 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/59729:MED17 ^@ http://purl.uniprot.org/uniprot/H0ZRI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59729:LOC100220586 ^@ http://purl.uniprot.org/uniprot/B5FYF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/59729:SWS2 ^@ http://purl.uniprot.org/uniprot/Q9IA34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/59729:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/H0ZP73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/59729:GLYR1 ^@ http://purl.uniprot.org/uniprot/A0A674GYC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/59729:MTFR2 ^@ http://purl.uniprot.org/uniprot/H0ZKP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/59729:SCG2 ^@ http://purl.uniprot.org/uniprot/H0ZC27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/59729:PDK1 ^@ http://purl.uniprot.org/uniprot/H0ZDY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/59729:PDE7A ^@ http://purl.uniprot.org/uniprot/A0A674HNZ5|||http://purl.uniprot.org/uniprot/H0ZLY6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59729:NFIA ^@ http://purl.uniprot.org/uniprot/A0A674H003 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/59729:CACNG1 ^@ http://purl.uniprot.org/uniprot/H0Z1T0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/59729:SDF4 ^@ http://purl.uniprot.org/uniprot/A0A674GP65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Golgi apparatus lumen http://togogenome.org/gene/59729:PPIC ^@ http://purl.uniprot.org/uniprot/B5KFI6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59729:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A674GVX0|||http://purl.uniprot.org/uniprot/A0A674HD38|||http://purl.uniprot.org/uniprot/H0ZE51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/59729:ATP5F1D ^@ http://purl.uniprot.org/uniprot/B5FZC5 ^@ Similarity ^@ Belongs to the ATPase epsilon chain family. http://togogenome.org/gene/59729:COQ9 ^@ http://purl.uniprot.org/uniprot/B5FZ62|||http://purl.uniprot.org/uniprot/H0Z3N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/59729:GNPDA2 ^@ http://purl.uniprot.org/uniprot/H0ZDN6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/59729:INSIG2 ^@ http://purl.uniprot.org/uniprot/A0A674HPT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/59729:ESR1 ^@ http://purl.uniprot.org/uniprot/Q91250 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).|||Nucleus|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/59729:AGT ^@ http://purl.uniprot.org/uniprot/H0ZI58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/59729:MDFIC ^@ http://purl.uniprot.org/uniprot/H0Z4G4 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/59729:C1GALT1 ^@ http://purl.uniprot.org/uniprot/H0YTV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.|||Membrane http://togogenome.org/gene/59729:ATP5PB ^@ http://purl.uniprot.org/uniprot/B5FZ05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/59729:MED21 ^@ http://purl.uniprot.org/uniprot/B5G0X4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59729:PGK1 ^@ http://purl.uniprot.org/uniprot/H0Z6P7 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/59729:LSM1 ^@ http://purl.uniprot.org/uniprot/B5FZU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||LSm subunits form a heteromer with a donut shape.|||P-body|||Probably involved with other LSm subunits in the general process of degradation of mRNAs. http://togogenome.org/gene/59729:LOC100229427 ^@ http://purl.uniprot.org/uniprot/H0ZKJ1 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/59729:CAND1 ^@ http://purl.uniprot.org/uniprot/H0Z8J5 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/59729:MRPL9 ^@ http://purl.uniprot.org/uniprot/B5FXJ0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/59729:MYOZ2 ^@ http://purl.uniprot.org/uniprot/H0YUH7 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/59729:ARRDC2 ^@ http://purl.uniprot.org/uniprot/H0YQ68 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/59729:JUN ^@ http://purl.uniprot.org/uniprot/H0ZHC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/59729:ARL3 ^@ http://purl.uniprot.org/uniprot/B5FYQ4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/59729:KEG28_p03 ^@ http://purl.uniprot.org/uniprot/Q27GV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:IGF1R ^@ http://purl.uniprot.org/uniprot/H0ZEE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/59729:SCAMP2 ^@ http://purl.uniprot.org/uniprot/H0Z0I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/59729:TPH2 ^@ http://purl.uniprot.org/uniprot/H0ZAE3 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/59729:GMFB ^@ http://purl.uniprot.org/uniprot/A0A674HSE9 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/59729:DAD1 ^@ http://purl.uniprot.org/uniprot/B5FXK7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/59729:KDELR3 ^@ http://purl.uniprot.org/uniprot/H0ZJG5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/H0ZPM1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/59729:MPG ^@ http://purl.uniprot.org/uniprot/H0Z1V7 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/59729:GTF2A2 ^@ http://purl.uniprot.org/uniprot/B5FXF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/59729:HMCES ^@ http://purl.uniprot.org/uniprot/H0ZBV0 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/59729:ITM2A ^@ http://purl.uniprot.org/uniprot/B5KFF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/59729:SYT1 ^@ http://purl.uniprot.org/uniprot/Q2XQH2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/59729:SERINC1 ^@ http://purl.uniprot.org/uniprot/H0ZNL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/59729:LOC100223404 ^@ http://purl.uniprot.org/uniprot/H0ZDE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59729:LOC100222254 ^@ http://purl.uniprot.org/uniprot/B5FXR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:NTNG2 ^@ http://purl.uniprot.org/uniprot/A0A674HP05 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:CDC26 ^@ http://purl.uniprot.org/uniprot/B5FXX3 ^@ Similarity ^@ Belongs to the CDC26 family. http://togogenome.org/gene/59729:LYZ ^@ http://purl.uniprot.org/uniprot/B5KFT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 22 family.|||Secreted http://togogenome.org/gene/59729:TSSC4 ^@ http://purl.uniprot.org/uniprot/H0ZG26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:IPO5 ^@ http://purl.uniprot.org/uniprot/A0A674GMR7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59729:NAA35 ^@ http://purl.uniprot.org/uniprot/A0A674HHI3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/59729:SPTBN1 ^@ http://purl.uniprot.org/uniprot/A0A674GV67 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/59729:BCR ^@ http://purl.uniprot.org/uniprot/A0A674GR37 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/59729:LOC100221856 ^@ http://purl.uniprot.org/uniprot/H0ZMC6 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/59729:SELENOK ^@ http://purl.uniprot.org/uniprot/B5G034 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein K family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59729:PRKCQ ^@ http://purl.uniprot.org/uniprot/H0YUY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/59729:UBALD1 ^@ http://purl.uniprot.org/uniprot/H0Z100 ^@ Similarity ^@ Belongs to the UBALD family. http://togogenome.org/gene/59729:ABCD2 ^@ http://purl.uniprot.org/uniprot/H0YZ21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:ELOVL4 ^@ http://purl.uniprot.org/uniprot/A0A674GJ08 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||Oligomer.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/59729:SEPTIN3 ^@ http://purl.uniprot.org/uniprot/A0A674H815 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm http://togogenome.org/gene/59729:SGCD ^@ http://purl.uniprot.org/uniprot/A0A674HNL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/59729:RPL38 ^@ http://purl.uniprot.org/uniprot/B5FYZ2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/59729:TTR ^@ http://purl.uniprot.org/uniprot/B5G260 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/59729:EIF4A3 ^@ http://purl.uniprot.org/uniprot/B5FZY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity). Involved in craniofacial development (By similarity).|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||Cytoplasm|||Identified in the spliceosome C complex. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains casc3, eif4a3, magoh and rbm8a.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/59729:LPAR1 ^@ http://purl.uniprot.org/uniprot/A0A674GJ60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/59729:EMP2 ^@ http://purl.uniprot.org/uniprot/H0Z2Z6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/59729:LOC100226305 ^@ http://purl.uniprot.org/uniprot/B5FYW5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:NDUFS4 ^@ http://purl.uniprot.org/uniprot/B5FZK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:ANP32A ^@ http://purl.uniprot.org/uniprot/A0A674GQF9|||http://purl.uniprot.org/uniprot/B5FYC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/59729:SLC1A7 ^@ http://purl.uniprot.org/uniprot/A0A674HI47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/59729:LOC100190143 ^@ http://purl.uniprot.org/uniprot/B5FYD5 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/59729:BOLA1 ^@ http://purl.uniprot.org/uniprot/B5G4P4 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/59729:LOC100222183 ^@ http://purl.uniprot.org/uniprot/D8FT02 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/59729:LOC100226437 ^@ http://purl.uniprot.org/uniprot/B5G1W9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:TIMM10 ^@ http://purl.uniprot.org/uniprot/B5FXH3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/59729:ERG ^@ http://purl.uniprot.org/uniprot/A0A674G9K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59729:CCK ^@ http://purl.uniprot.org/uniprot/B5FZ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/59729:SEC22A ^@ http://purl.uniprot.org/uniprot/H0Z1M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/59729:SYT17 ^@ http://purl.uniprot.org/uniprot/H0ZGL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Membrane http://togogenome.org/gene/59729:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A674GYB2|||http://purl.uniprot.org/uniprot/H0Z087 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/59729:TMSB4X ^@ http://purl.uniprot.org/uniprot/B5G0T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/59729:ING1 ^@ http://purl.uniprot.org/uniprot/A0A674H5S7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/59729:TIMM9 ^@ http://purl.uniprot.org/uniprot/B5FY66 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/59729:LEP ^@ http://purl.uniprot.org/uniprot/A0A023GUT0 ^@ Similarity ^@ Belongs to the leptin family. http://togogenome.org/gene/59729:ACO2 ^@ http://purl.uniprot.org/uniprot/H0ZI30 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/59729:SMIM8 ^@ http://purl.uniprot.org/uniprot/H0ZQE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/59729:CNR1 ^@ http://purl.uniprot.org/uniprot/P56971 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids (By similarity). Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues (By similarity). Regulates cellular respiration and energy production in response to cannabinoids (By similarity). Signaling typically involves reduction in cyclic AMP (By similarity).|||Mitochondrion outer membrane|||Palmitoylation at Cys-417 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits.|||Presynapse|||axon http://togogenome.org/gene/59729:NPY2R ^@ http://purl.uniprot.org/uniprot/A0A674GEW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:RPL17 ^@ http://purl.uniprot.org/uniprot/Q563Y0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/59729:LHX8 ^@ http://purl.uniprot.org/uniprot/H0ZJH3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:PPP2R5E ^@ http://purl.uniprot.org/uniprot/A0A674HKN2 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/59729:LOC100230788 ^@ http://purl.uniprot.org/uniprot/H0ZDD6 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/59729:POLR2K ^@ http://purl.uniprot.org/uniprot/B5FYP8 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/59729:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A674G8J0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/59729:UQCRH ^@ http://purl.uniprot.org/uniprot/B5G1C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:MED6 ^@ http://purl.uniprot.org/uniprot/B5FYR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59729:ATP5MK ^@ http://purl.uniprot.org/uniprot/B5FZ09 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/59729:USP44 ^@ http://purl.uniprot.org/uniprot/A0A674GD34 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59729:CREBL2 ^@ http://purl.uniprot.org/uniprot/B5G0C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/59729:DUT ^@ http://purl.uniprot.org/uniprot/B5FY95 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/59729:CFAP298 ^@ http://purl.uniprot.org/uniprot/B5FXS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/59729:NUP50 ^@ http://purl.uniprot.org/uniprot/H0ZNQ1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/59729:MRPS17 ^@ http://purl.uniprot.org/uniprot/B5G022 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/59729:AIFM2 ^@ http://purl.uniprot.org/uniprot/B5FXE5 ^@ Activity Regulation|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms. Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death.|||Belongs to the FAD-dependent oxidoreductase family.|||Binds 6-hydroxy-FAD non-covalently.|||Cell membrane|||Cytoplasm|||Lipid droplet|||Mitochondrion membrane|||N-myristoylation at Gly-2 mediates the recruitment to lipid droplets and plasma membrane.|||Nucleus|||The modification by 4-hydroxy-2-nonenal (HNE) adduction in mitochondria results in loss of the oxidoreductase activity and activation of a novel function in mitochondrial oxidative stress signaling. http://togogenome.org/gene/59729:RND3 ^@ http://purl.uniprot.org/uniprot/H0ZP24 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/59729:OLFM1 ^@ http://purl.uniprot.org/uniprot/A0A674GQ86|||http://purl.uniprot.org/uniprot/A0A674GUN1 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/59729:DPH5 ^@ http://purl.uniprot.org/uniprot/H0Z3P0 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/59729:NDUFA8 ^@ http://purl.uniprot.org/uniprot/B5FYB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion intermembrane space http://togogenome.org/gene/59729:VXN ^@ http://purl.uniprot.org/uniprot/A0A674GV03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vexin family.|||Cell membrane|||Membrane|||Nucleus http://togogenome.org/gene/59729:LOC100190585 ^@ http://purl.uniprot.org/uniprot/B5G106 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59729:LOC100218635 ^@ http://purl.uniprot.org/uniprot/H0ZG86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:XRCC3 ^@ http://purl.uniprot.org/uniprot/H0ZRL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Cytoplasm|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.|||Nucleus http://togogenome.org/gene/59729:LOC100230571 ^@ http://purl.uniprot.org/uniprot/A0A674G9K1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with UHRF2/NIRF.|||May be involved in cell cycle regulation.|||Nucleus http://togogenome.org/gene/59729:PGS1 ^@ http://purl.uniprot.org/uniprot/H0YYR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/59729:MMAB ^@ http://purl.uniprot.org/uniprot/B5FZU3 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/59729:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A674HDZ1|||http://purl.uniprot.org/uniprot/H0YPY7 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/59729:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/A0A674G711 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:CSNK2A2 ^@ http://purl.uniprot.org/uniprot/A0A674HFG3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:CENPI ^@ http://purl.uniprot.org/uniprot/A0A674GK53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-I/CTF3 family.|||Nucleus|||centromere http://togogenome.org/gene/59729:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/H0ZF04 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59729:VPS26A ^@ http://purl.uniprot.org/uniprot/B5FYY8 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/59729:LOC100217789 ^@ http://purl.uniprot.org/uniprot/H0Z2B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/59729:LOC100190204 ^@ http://purl.uniprot.org/uniprot/B5FYW2 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/59729:PPFIA1 ^@ http://purl.uniprot.org/uniprot/A0A674GXR5|||http://purl.uniprot.org/uniprot/A0A674HTK9 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/59729:SERPINB5 ^@ http://purl.uniprot.org/uniprot/H0YV05 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/59729:PRKCD ^@ http://purl.uniprot.org/uniprot/H0Z2C3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.|||Cytoplasm|||Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||perinuclear region http://togogenome.org/gene/59729:SEC11A ^@ http://purl.uniprot.org/uniprot/B5G294 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:VPS4B ^@ http://purl.uniprot.org/uniprot/H0YUZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/59729:CEBPZ ^@ http://purl.uniprot.org/uniprot/H0ZE57 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/59729:CMBL ^@ http://purl.uniprot.org/uniprot/H0ZB89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/59729:SLC16A3 ^@ http://purl.uniprot.org/uniprot/A0A674GM39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/59729:TGFB2 ^@ http://purl.uniprot.org/uniprot/H0YX95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/59729:NDUFAF2 ^@ http://purl.uniprot.org/uniprot/H0YWW4 ^@ Similarity ^@ Belongs to the complex I NDUFA12 subunit family. http://togogenome.org/gene/59729:C7H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A674HR33 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/59729:ISCU ^@ http://purl.uniprot.org/uniprot/B5FYX1 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/59729:LOC100189947 ^@ http://purl.uniprot.org/uniprot/B5FX61 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/59729:RFX3 ^@ http://purl.uniprot.org/uniprot/A0A674HN21|||http://purl.uniprot.org/uniprot/H0Z4H7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ITPA ^@ http://purl.uniprot.org/uniprot/B5FZM9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/59729:ACSL5 ^@ http://purl.uniprot.org/uniprot/H0ZKJ7 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/59729:RPS3 ^@ http://purl.uniprot.org/uniprot/B5FZR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||spindle http://togogenome.org/gene/59729:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A674GF37 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/59729:PCYT1B ^@ http://purl.uniprot.org/uniprot/B5FXG8 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/59729:ATPAF1 ^@ http://purl.uniprot.org/uniprot/B5FZC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/59729:SMPX ^@ http://purl.uniprot.org/uniprot/A0A674HVT1 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/59729:SYNGR1 ^@ http://purl.uniprot.org/uniprot/A0A674H9K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/59729:KCNE4 ^@ http://purl.uniprot.org/uniprot/A0A674GBP9 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/59729:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A674GHC7|||http://purl.uniprot.org/uniprot/B5FX99 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/59729:EMC7 ^@ http://purl.uniprot.org/uniprot/B5FZG9 ^@ Similarity|||Subunit ^@ Belongs to the EMC7 family.|||Component of the ER membrane protein complex (EMC). http://togogenome.org/gene/59729:NTS ^@ http://purl.uniprot.org/uniprot/B5G1S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/59729:LOC100219615 ^@ http://purl.uniprot.org/uniprot/A0A674GY87|||http://purl.uniprot.org/uniprot/H0ZH32 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/59729:NLGN1 ^@ http://purl.uniprot.org/uniprot/A0A674G931|||http://purl.uniprot.org/uniprot/A0A674HJX5|||http://purl.uniprot.org/uniprot/A0A674HQA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:PYCR3 ^@ http://purl.uniprot.org/uniprot/B5G1C0 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/59729:EIF2B2 ^@ http://purl.uniprot.org/uniprot/B5FYM1 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/59729:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/H0YP37 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/59729:DHFR ^@ http://purl.uniprot.org/uniprot/H0Z9R7 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/59729:KEG28_p05 ^@ http://purl.uniprot.org/uniprot/Q27GW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4L family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:HMGA2 ^@ http://purl.uniprot.org/uniprot/A0A674HW74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/59729:ZIC1 ^@ http://purl.uniprot.org/uniprot/H0ZET7 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/59729:GTF2E2 ^@ http://purl.uniprot.org/uniprot/A0A674GLB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/59729:LOC101233594 ^@ http://purl.uniprot.org/uniprot/B5FYW5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:NDUFB5 ^@ http://purl.uniprot.org/uniprot/B5G0I5 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/59729:ISOC1 ^@ http://purl.uniprot.org/uniprot/H0YQ18 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/59729:RAX2 ^@ http://purl.uniprot.org/uniprot/H0YPE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/59729:RPS3A ^@ http://purl.uniprot.org/uniprot/B5FZS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis (By similarity).|||Cytoplasm|||Nucleus|||nucleolus http://togogenome.org/gene/59729:MMGT1 ^@ http://purl.uniprot.org/uniprot/A0A674HMY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/59729:PSMA5 ^@ http://purl.uniprot.org/uniprot/B5FYJ2|||http://purl.uniprot.org/uniprot/B5KFM6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/59729:LOC100217958 ^@ http://purl.uniprot.org/uniprot/A0A674GG33 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59729:SLC25A21 ^@ http://purl.uniprot.org/uniprot/H0ZP51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59729:RPL23A ^@ http://purl.uniprot.org/uniprot/B5FZ39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/59729:PHPT1 ^@ http://purl.uniprot.org/uniprot/B5FXN1 ^@ Function|||Similarity ^@ Belongs to the janus family.|||Exhibits phosphohistidine phosphatase activity. http://togogenome.org/gene/59729:FSCN1 ^@ http://purl.uniprot.org/uniprot/B5FYS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/59729:PSMC1 ^@ http://purl.uniprot.org/uniprot/B5FZJ3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/59729:SLC24A2 ^@ http://purl.uniprot.org/uniprot/H0Z1L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/59729:CCT8 ^@ http://purl.uniprot.org/uniprot/H0ZTP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/59729:HSD3B1 ^@ http://purl.uniprot.org/uniprot/Q6SYC3 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/59729:LOC100221958 ^@ http://purl.uniprot.org/uniprot/H0ZAG2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/59729:COX6A1 ^@ http://purl.uniprot.org/uniprot/B5G2I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:FAM234A ^@ http://purl.uniprot.org/uniprot/H0Z1G1 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/59729:ANKH ^@ http://purl.uniprot.org/uniprot/A0A674GXC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/59729:LYRM7 ^@ http://purl.uniprot.org/uniprot/H0YQ52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/59729:PHETA1 ^@ http://purl.uniprot.org/uniprot/H0Z7W3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sesquipedalian family.|||Early endosome|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/59729:FGF14 ^@ http://purl.uniprot.org/uniprot/H0ZKS7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59729:KEG28_p11 ^@ http://purl.uniprot.org/uniprot/Q27GW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:FZD7 ^@ http://purl.uniprot.org/uniprot/H0ZIP9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:FBLN7 ^@ http://purl.uniprot.org/uniprot/H0ZAS7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:PLN ^@ http://purl.uniprot.org/uniprot/A0A674GSS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/59729:RAB14 ^@ http://purl.uniprot.org/uniprot/B5G1Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/59729:ADAM23 ^@ http://purl.uniprot.org/uniprot/A0A674HP74 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:NME1 ^@ http://purl.uniprot.org/uniprot/A0A674H9E8 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/59729:GREB1 ^@ http://purl.uniprot.org/uniprot/H0ZS76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GREB1 family.|||Membrane http://togogenome.org/gene/59729:NDUFA11 ^@ http://purl.uniprot.org/uniprot/B5G3M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA11 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:MRPL14 ^@ http://purl.uniprot.org/uniprot/B5G3W8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/59729:NMUR1 ^@ http://purl.uniprot.org/uniprot/H0ZHN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/59729:LOC100227828 ^@ http://purl.uniprot.org/uniprot/A0A674GMT5 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/59729:CRKL ^@ http://purl.uniprot.org/uniprot/A0A674H0B5 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/59729:PVALB ^@ http://purl.uniprot.org/uniprot/B5G1U4 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/59729:HMGN1 ^@ http://purl.uniprot.org/uniprot/B5FZ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/59729:MGST1 ^@ http://purl.uniprot.org/uniprot/B5G0B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/59729:ACBD5 ^@ http://purl.uniprot.org/uniprot/A0A674H6W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane http://togogenome.org/gene/59729:PGM3 ^@ http://purl.uniprot.org/uniprot/H0ZQN0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/59729:TCEA1 ^@ http://purl.uniprot.org/uniprot/A0A674H0E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/59729:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/Q9I8W8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the aldehyde dehydrogenase family.|||Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:10985355). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Lacks activity with benzaldehyde, acetaldehyde and octanal (PubMed:10985355). Displays complete lack of activity with citral (PubMed:10985355). Plays a significant role in the acquisition and production of learned songs (PubMed:10985355).|||Cytoplasm|||Expressed in the high vocal center (HVC) which integrates auditory and motor activities and constitutes a nodal nucleus on the song system.|||Homotetramer. http://togogenome.org/gene/59729:FABP6 ^@ http://purl.uniprot.org/uniprot/H0YPK0 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59729:NDUFB1 ^@ http://purl.uniprot.org/uniprot/B5FY01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:CLDN12 ^@ http://purl.uniprot.org/uniprot/A0A674GTI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/59729:TIMM17A ^@ http://purl.uniprot.org/uniprot/B5G2C9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:STX16 ^@ http://purl.uniprot.org/uniprot/A0A674GIK0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/59729:MRPL19 ^@ http://purl.uniprot.org/uniprot/B5FYH2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/59729:HTR1F ^@ http://purl.uniprot.org/uniprot/H0ZTI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/59729:RPS6 ^@ http://purl.uniprot.org/uniprot/B5FYB2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/59729:MED18 ^@ http://purl.uniprot.org/uniprot/H0Z6U5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59729:OSTC ^@ http://purl.uniprot.org/uniprot/H0Z0U1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/59729:DRD1 ^@ http://purl.uniprot.org/uniprot/H0YPZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:LOC100190084 ^@ http://purl.uniprot.org/uniprot/B5FXY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/59729:MED31 ^@ http://purl.uniprot.org/uniprot/B5G1M8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59729:TYR ^@ http://purl.uniprot.org/uniprot/H0ZRN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane|||Membrane http://togogenome.org/gene/59729:PSMC5 ^@ http://purl.uniprot.org/uniprot/B5G0X8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/59729:MEA1 ^@ http://purl.uniprot.org/uniprot/H0Z3D2 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/59729:BAMBI ^@ http://purl.uniprot.org/uniprot/B5G0B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/59729:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A674HKU7|||http://purl.uniprot.org/uniprot/H0YT72 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:RPL37 ^@ http://purl.uniprot.org/uniprot/Q563Y1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/59729:WDFY2 ^@ http://purl.uniprot.org/uniprot/A0A674GMQ3 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/59729:MAP2K3 ^@ http://purl.uniprot.org/uniprot/A0A674HQ61 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:MFAP1 ^@ http://purl.uniprot.org/uniprot/H0ZIT3 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/59729:LOC100228770 ^@ http://purl.uniprot.org/uniprot/H0Z1H9 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:CDC37L1 ^@ http://purl.uniprot.org/uniprot/H0Z449 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/59729:CHCHD6 ^@ http://purl.uniprot.org/uniprot/B5FXG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:GNRH1 ^@ http://purl.uniprot.org/uniprot/B7TCA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted http://togogenome.org/gene/59729:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/H0YZP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/59729:BCAS2 ^@ http://purl.uniprot.org/uniprot/B5G466|||http://purl.uniprot.org/uniprot/B5G470 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/59729:LOC100228336 ^@ http://purl.uniprot.org/uniprot/A0A674GRH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/59729:LWS ^@ http://purl.uniprot.org/uniprot/Q9IA33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/59729:BUD31 ^@ http://purl.uniprot.org/uniprot/B5FY87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/59729:ATP5MF ^@ http://purl.uniprot.org/uniprot/B5FY90 ^@ Function|||Similarity ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/59729:PTGES3L ^@ http://purl.uniprot.org/uniprot/B5G0B0 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/59729:LZIC ^@ http://purl.uniprot.org/uniprot/A0A674GVQ5 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/59729:RPL6 ^@ http://purl.uniprot.org/uniprot/A0A674GMD7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/59729:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A674GAN9 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/59729:BEND6 ^@ http://purl.uniprot.org/uniprot/A0A674G8W6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:NRXN3 ^@ http://purl.uniprot.org/uniprot/H0ZQ41 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:HOXB8 ^@ http://purl.uniprot.org/uniprot/H0YZ13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:CTSB ^@ http://purl.uniprot.org/uniprot/B5G358 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/59729:HS3ST5 ^@ http://purl.uniprot.org/uniprot/H0ZNZ3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59729:PPIB ^@ http://purl.uniprot.org/uniprot/B5G4N8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59729:S100B ^@ http://purl.uniprot.org/uniprot/B5FXV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/59729:CCR5 ^@ http://purl.uniprot.org/uniprot/A0A674GFP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59729:ALDH3A2 ^@ http://purl.uniprot.org/uniprot/B5FYG0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59729:APOA1 ^@ http://purl.uniprot.org/uniprot/B5G356 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/59729:HOXA7 ^@ http://purl.uniprot.org/uniprot/H0YXH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/59729:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/B5G0H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/59729:SETD3 ^@ http://purl.uniprot.org/uniprot/A0A674GWN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm http://togogenome.org/gene/59729:TMBIM4 ^@ http://purl.uniprot.org/uniprot/B5FXA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/59729:NGF ^@ http://purl.uniprot.org/uniprot/H0YRS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted http://togogenome.org/gene/59729:VAMP7 ^@ http://purl.uniprot.org/uniprot/H0Z4X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/59729:PSMA6 ^@ http://purl.uniprot.org/uniprot/B5FXD0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/59729:SCTR ^@ http://purl.uniprot.org/uniprot/H0ZMS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:KCNJ2 ^@ http://purl.uniprot.org/uniprot/H0YXD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/59729:HAGH ^@ http://purl.uniprot.org/uniprot/B5FYT6 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/59729:LOC100231622 ^@ http://purl.uniprot.org/uniprot/A0A674GN47 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/59729:RPA1 ^@ http://purl.uniprot.org/uniprot/H0Z5X0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/59729:CZIB ^@ http://purl.uniprot.org/uniprot/B5G1B4 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/59729:EIF3K ^@ http://purl.uniprot.org/uniprot/B5FYY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:COX6C ^@ http://purl.uniprot.org/uniprot/B5FZE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:ANXA4 ^@ http://purl.uniprot.org/uniprot/B5FXE8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/59729:PFKFB3 ^@ http://purl.uniprot.org/uniprot/H0YUX4 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/59729:GNAL ^@ http://purl.uniprot.org/uniprot/A0A674GS32 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/59729:BMP10 ^@ http://purl.uniprot.org/uniprot/A0A674HRA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/59729:HEXB ^@ http://purl.uniprot.org/uniprot/H0Z6E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/59729:PDCD10 ^@ http://purl.uniprot.org/uniprot/H0ZLF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:YAF2 ^@ http://purl.uniprot.org/uniprot/A0A674HML7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:LOC100190442 ^@ http://purl.uniprot.org/uniprot/B5G297 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59729:TOM1L2 ^@ http://purl.uniprot.org/uniprot/A0A674HRP7|||http://purl.uniprot.org/uniprot/H0ZAC1 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/59729:DHRS7 ^@ http://purl.uniprot.org/uniprot/H0ZRZ3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59729:OCIAD1 ^@ http://purl.uniprot.org/uniprot/B5G016 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/59729:TAF15 ^@ http://purl.uniprot.org/uniprot/H0Z2T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/59729:CLN8 ^@ http://purl.uniprot.org/uniprot/A0A674G832 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:GANC ^@ http://purl.uniprot.org/uniprot/H0ZLE6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/59729:IFI6 ^@ http://purl.uniprot.org/uniprot/B5G1Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/59729:MAN1B1 ^@ http://purl.uniprot.org/uniprot/H0YVR2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/59729:IAH1 ^@ http://purl.uniprot.org/uniprot/H0ZS19 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/59729:BTG1 ^@ http://purl.uniprot.org/uniprot/H0ZCZ0 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/59729:RUNX2 ^@ http://purl.uniprot.org/uniprot/H0ZSP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:LOC100218573 ^@ http://purl.uniprot.org/uniprot/H0YP10 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:ANXA1 ^@ http://purl.uniprot.org/uniprot/A0A674GDT8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasm|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium http://togogenome.org/gene/59729:LOC100189956 ^@ http://purl.uniprot.org/uniprot/B5FX72 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/59729:PANK4 ^@ http://purl.uniprot.org/uniprot/H0YXF9 ^@ Similarity|||Subunit ^@ Belongs to the type II pantothenate kinase family.|||Homodimer. Interacts with PKM.|||In the N-terminal section; belongs to the type II pantothenate kinase family. http://togogenome.org/gene/59729:LOC100218354 ^@ http://purl.uniprot.org/uniprot/B5G047 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:PPCS ^@ http://purl.uniprot.org/uniprot/B5FXZ6 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/59729:RNF170 ^@ http://purl.uniprot.org/uniprot/A0A674H4J4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:AFF4 ^@ http://purl.uniprot.org/uniprot/A0A674GNB8 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/59729:NDUFB3 ^@ http://purl.uniprot.org/uniprot/B5FYG8|||http://purl.uniprot.org/uniprot/B5FYH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:LIMK2 ^@ http://purl.uniprot.org/uniprot/H0ZHI5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/59729:WNT7B ^@ http://purl.uniprot.org/uniprot/A0A674HNV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59729:HBE1 ^@ http://purl.uniprot.org/uniprot/B5FX70 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59729:CLTCL1 ^@ http://purl.uniprot.org/uniprot/A0A674GN64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/59729:LOC100190001 ^@ http://purl.uniprot.org/uniprot/B5FXD3 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/59729:FAM241A ^@ http://purl.uniprot.org/uniprot/A0A674H8W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/59729:KATNAL1 ^@ http://purl.uniprot.org/uniprot/A0A674GK57 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/59729:BCL2A1 ^@ http://purl.uniprot.org/uniprot/H0ZCL9 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/59729:FMC1 ^@ http://purl.uniprot.org/uniprot/B5FXE7 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/59729:CHMP6 ^@ http://purl.uniprot.org/uniprot/H0YXU4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/59729:RAB33B ^@ http://purl.uniprot.org/uniprot/A0A674H5L7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/59729:TPT1 ^@ http://purl.uniprot.org/uniprot/B5FZD8 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/59729:POU6F2 ^@ http://purl.uniprot.org/uniprot/H0YUE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/59729:LOC100190229 ^@ http://purl.uniprot.org/uniprot/B5FZ51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space|||Required for assembly of mitochondrial respiratory chain complexes. http://togogenome.org/gene/59729:LOC100231234 ^@ http://purl.uniprot.org/uniprot/A0A674GFS1|||http://purl.uniprot.org/uniprot/H0YXV7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/59729:NRN1 ^@ http://purl.uniprot.org/uniprot/D2KZY5 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/59729:SH3GL2 ^@ http://purl.uniprot.org/uniprot/H0Z210 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/59729:ASRGL1 ^@ http://purl.uniprot.org/uniprot/H0ZR41 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/59729:TM9SF2 ^@ http://purl.uniprot.org/uniprot/H0ZL20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/59729:HDAC2 ^@ http://purl.uniprot.org/uniprot/A0A674GYU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/59729:PGLS ^@ http://purl.uniprot.org/uniprot/B5FXQ4 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/59729:DHCR7 ^@ http://purl.uniprot.org/uniprot/A0A674GDI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/59729:PICK1 ^@ http://purl.uniprot.org/uniprot/A0A674HR02 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.|||cytoskeleton|||perinuclear region|||synaptosome http://togogenome.org/gene/59729:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A674HCA5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:HBAA ^@ http://purl.uniprot.org/uniprot/B5G3P7 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59729:KDM5A ^@ http://purl.uniprot.org/uniprot/H0ZQX3 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/59729:TSNAX ^@ http://purl.uniprot.org/uniprot/H0ZIJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/59729:SMC3 ^@ http://purl.uniprot.org/uniprot/H0ZK71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/59729:CHD1 ^@ http://purl.uniprot.org/uniprot/Q800S6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:SNAPIN ^@ http://purl.uniprot.org/uniprot/B5G4H7 ^@ Similarity ^@ Belongs to the SNAPIN family. http://togogenome.org/gene/59729:PRKRIP1 ^@ http://purl.uniprot.org/uniprot/B5G201 ^@ Similarity ^@ Belongs to the PRKRIP1 family. http://togogenome.org/gene/59729:BBS5 ^@ http://purl.uniprot.org/uniprot/H0ZBX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS5 family.|||Membrane|||Required for ciliogenesis.|||centriolar satellite|||cilium membrane http://togogenome.org/gene/59729:PPARA ^@ http://purl.uniprot.org/uniprot/H0ZNI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/59729:LDB3 ^@ http://purl.uniprot.org/uniprot/H0Z5L0 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/59729:SNRPD1 ^@ http://purl.uniprot.org/uniprot/B5FY37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/59729:POLR2C ^@ http://purl.uniprot.org/uniprot/B5FZ64 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/59729:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A674GJB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:LOC100223312 ^@ http://purl.uniprot.org/uniprot/H0YQL7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59729:DPM3 ^@ http://purl.uniprot.org/uniprot/B5FX58 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/59729:LOC100217677 ^@ http://purl.uniprot.org/uniprot/H0ZJR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the noggin family.|||Secreted http://togogenome.org/gene/59729:NFE2L2 ^@ http://purl.uniprot.org/uniprot/H0ZFD5 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/59729:LOC100223994 ^@ http://purl.uniprot.org/uniprot/H0ZN48 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59729:SUB1 ^@ http://purl.uniprot.org/uniprot/B5FYR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Nucleus http://togogenome.org/gene/59729:PMVK ^@ http://purl.uniprot.org/uniprot/B5G1H5 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/59729:MRRF ^@ http://purl.uniprot.org/uniprot/B5FXB2 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/59729:PTCH1 ^@ http://purl.uniprot.org/uniprot/H0YQK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/59729:PSMB2 ^@ http://purl.uniprot.org/uniprot/H0YTV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:SNCA ^@ http://purl.uniprot.org/uniprot/Q4JHT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synuclein family.|||Membrane|||Nucleus|||Secreted|||Synapse http://togogenome.org/gene/59729:CEL ^@ http://purl.uniprot.org/uniprot/H0Z4H9 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/59729:RORB ^@ http://purl.uniprot.org/uniprot/A0A674GCR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59729:SYF2 ^@ http://purl.uniprot.org/uniprot/B5FYV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/59729:MDH1 ^@ http://purl.uniprot.org/uniprot/B5G179 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer. http://togogenome.org/gene/59729:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A674GTM4|||http://purl.uniprot.org/uniprot/A0A674HJF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/59729:LOC100221944 ^@ http://purl.uniprot.org/uniprot/B5FXC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:UCHL1 ^@ http://purl.uniprot.org/uniprot/Q4ZIS0 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/59729:SELENOS ^@ http://purl.uniprot.org/uniprot/B5FZK0|||http://purl.uniprot.org/uniprot/B5FZK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein S family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:PSMB1 ^@ http://purl.uniprot.org/uniprot/B5G4R1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:MED7 ^@ http://purl.uniprot.org/uniprot/B5FX93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59729:AHSA1 ^@ http://purl.uniprot.org/uniprot/B5FYT0 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/59729:MGME1 ^@ http://purl.uniprot.org/uniprot/H0Z676 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGME1 family.|||Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair.|||Mitochondrion http://togogenome.org/gene/59729:EPN2 ^@ http://purl.uniprot.org/uniprot/A0A674GLN6|||http://purl.uniprot.org/uniprot/H0Z9I7 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/59729:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A674H4Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/59729:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/H0Z6M1 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/59729:UBE2N ^@ http://purl.uniprot.org/uniprot/B5G4T1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59729:NMUR2 ^@ http://purl.uniprot.org/uniprot/H0YR51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/59729:NDUFA5 ^@ http://purl.uniprot.org/uniprot/B5FYU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:FGB ^@ http://purl.uniprot.org/uniprot/H0Z4C6 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/59729:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/B5FXJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||Endoplasmic reticulum|||Golgi apparatus|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||perinuclear region http://togogenome.org/gene/59729:NCAPG ^@ http://purl.uniprot.org/uniprot/A0A674H9G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/59729:KEG28_p13 ^@ http://purl.uniprot.org/uniprot/Q27GW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:MIS12 ^@ http://purl.uniprot.org/uniprot/H0Z198 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mis12 family.|||kinetochore http://togogenome.org/gene/59729:TMEM208 ^@ http://purl.uniprot.org/uniprot/B5G1U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/59729:NKX6-3 ^@ http://purl.uniprot.org/uniprot/H0Z4B1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:TATDN3 ^@ http://purl.uniprot.org/uniprot/B5KFT5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/59729:TMEM170B ^@ http://purl.uniprot.org/uniprot/A0A674G9S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/59729:SULT4A1 ^@ http://purl.uniprot.org/uniprot/B5G2M5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59729:SEMA3C ^@ http://purl.uniprot.org/uniprot/A0A674GDI4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59729:SLC13A3 ^@ http://purl.uniprot.org/uniprot/H0Z4Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/59729:ANXA5 ^@ http://purl.uniprot.org/uniprot/A0A674H3S5 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/59729:LOC100221480 ^@ http://purl.uniprot.org/uniprot/H0ZG86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:CHST12 ^@ http://purl.uniprot.org/uniprot/H0ZCS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:OTOP1 ^@ http://purl.uniprot.org/uniprot/H0ZI05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:NDUFB8 ^@ http://purl.uniprot.org/uniprot/B5G3W6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:LOC100229913 ^@ http://purl.uniprot.org/uniprot/H0Z677 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:AIG1 ^@ http://purl.uniprot.org/uniprot/A0A674GQV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/59729:LOC100190115 ^@ http://purl.uniprot.org/uniprot/B5FY74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/59729:SLC7A1 ^@ http://purl.uniprot.org/uniprot/H0ZN67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:SNX9 ^@ http://purl.uniprot.org/uniprot/H0ZLH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/59729:HEBP2 ^@ http://purl.uniprot.org/uniprot/A0A674HKQ2 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/59729:RPL18A ^@ http://purl.uniprot.org/uniprot/H0Z7S1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/59729:ANAPC4 ^@ http://purl.uniprot.org/uniprot/H1A1Y0 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/59729:CHMP2B ^@ http://purl.uniprot.org/uniprot/H0ZTI7 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/59729:LOC100223570 ^@ http://purl.uniprot.org/uniprot/A0A674H3X3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:CXCL12 ^@ http://purl.uniprot.org/uniprot/B5FX95 ^@ Similarity ^@ Belongs to the intercrine alpha (chemokine CxC) family. http://togogenome.org/gene/59729:RPS28 ^@ http://purl.uniprot.org/uniprot/B5FY09 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/59729:ARRDC3 ^@ http://purl.uniprot.org/uniprot/H0YR15 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/59729:GGA1 ^@ http://purl.uniprot.org/uniprot/H0ZJY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/59729:SLC16A6 ^@ http://purl.uniprot.org/uniprot/H0Z123 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:EBNA1BP2 ^@ http://purl.uniprot.org/uniprot/B5FZW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||Required for the processing of the 27S pre-rRNA.|||nucleolus http://togogenome.org/gene/59729:EGFR ^@ http://purl.uniprot.org/uniprot/H0YU95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/59729:DEGS2 ^@ http://purl.uniprot.org/uniprot/H0ZR84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:LYPLA1 ^@ http://purl.uniprot.org/uniprot/A0A674HNX0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/59729:UBR2 ^@ http://purl.uniprot.org/uniprot/A0A674HL50 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/59729:LOC100220663 ^@ http://purl.uniprot.org/uniprot/B5G139 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MOZART2 family.|||centrosome|||spindle http://togogenome.org/gene/59729:GGPS1 ^@ http://purl.uniprot.org/uniprot/A0A674HVI1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/59729:RBP2 ^@ http://purl.uniprot.org/uniprot/H0Z426 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59729:EMC6 ^@ http://purl.uniprot.org/uniprot/H0Z950 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:ACYP1 ^@ http://purl.uniprot.org/uniprot/B5G0Y5|||http://purl.uniprot.org/uniprot/B5G0Y6 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/59729:SKAP2 ^@ http://purl.uniprot.org/uniprot/H0YXF4 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/59729:RARRES2 ^@ http://purl.uniprot.org/uniprot/B5FX76 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59729:SNRPB ^@ http://purl.uniprot.org/uniprot/B5G4G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/59729:IDUA ^@ http://purl.uniprot.org/uniprot/A0A674GVN9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 39 family. http://togogenome.org/gene/59729:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/H0YP47 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/59729:UFM1 ^@ http://purl.uniprot.org/uniprot/A0A674H1L9 ^@ Similarity ^@ Belongs to the UFM1 family. http://togogenome.org/gene/59729:LOC101234123 ^@ http://purl.uniprot.org/uniprot/A0A674GYA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/59729:TEKT3 ^@ http://purl.uniprot.org/uniprot/H0Z3R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/59729:MC1R ^@ http://purl.uniprot.org/uniprot/H0ZCF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/59729:ABCG5 ^@ http://purl.uniprot.org/uniprot/A0A674HR94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/59729:MRPS33 ^@ http://purl.uniprot.org/uniprot/B5G224 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/59729:MAP3K21 ^@ http://purl.uniprot.org/uniprot/H0ZIV1 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/59729:NIPSNAP1 ^@ http://purl.uniprot.org/uniprot/B5FXC1 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/59729:ANAPC2 ^@ http://purl.uniprot.org/uniprot/A0A674GLH7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/59729:ATP6AP1L ^@ http://purl.uniprot.org/uniprot/H0Z985 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/59729:LOC100224234 ^@ http://purl.uniprot.org/uniprot/A0A674HDM1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59729:RUNX3 ^@ http://purl.uniprot.org/uniprot/H0YSA1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ABCC10 ^@ http://purl.uniprot.org/uniprot/H0ZFL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:TALDO1 ^@ http://purl.uniprot.org/uniprot/H0ZBV9 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/59729:NAA60 ^@ http://purl.uniprot.org/uniprot/H0Z146 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/59729:USP35 ^@ http://purl.uniprot.org/uniprot/H0ZS03 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59729:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/B5FXT2 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/59729:HCRTR2 ^@ http://purl.uniprot.org/uniprot/H0ZRI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:PKIG ^@ http://purl.uniprot.org/uniprot/B5FY16 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/59729:EXOC8 ^@ http://purl.uniprot.org/uniprot/H1A530 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/59729:ZADH2 ^@ http://purl.uniprot.org/uniprot/A0A674HAV8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/59729:MADD ^@ http://purl.uniprot.org/uniprot/H0ZJM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MADD family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/59729:NOP58 ^@ http://purl.uniprot.org/uniprot/H0ZIN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/59729:LOC100223320 ^@ http://purl.uniprot.org/uniprot/A0A674GHD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/59729:ST6GALNAC1 ^@ http://purl.uniprot.org/uniprot/H0ZBX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59729:NAPG ^@ http://purl.uniprot.org/uniprot/A0A674HKS1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/59729:DNAL4 ^@ http://purl.uniprot.org/uniprot/A0A674GA88|||http://purl.uniprot.org/uniprot/B5G3W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/59729:FCF1 ^@ http://purl.uniprot.org/uniprot/A0A674HJ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/59729:PIGN ^@ http://purl.uniprot.org/uniprot/H0YUT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/59729:VWC2L ^@ http://purl.uniprot.org/uniprot/H0YXF0 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/59729:CYRIA ^@ http://purl.uniprot.org/uniprot/A0A674GPW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/59729:HPGD ^@ http://purl.uniprot.org/uniprot/H0Z7D9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59729:LOC105759428 ^@ http://purl.uniprot.org/uniprot/H0ZKC7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:LOC100190731 ^@ http://purl.uniprot.org/uniprot/B5G2T6 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/59729:LOC100219720 ^@ http://purl.uniprot.org/uniprot/H0Z182 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/59729:BBLN ^@ http://purl.uniprot.org/uniprot/B5FY93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0184 (EST00098) family.|||Cell junction|||Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology.|||cytoskeleton http://togogenome.org/gene/59729:EIF3I ^@ http://purl.uniprot.org/uniprot/B5FZ19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/59729:SFMBT2 ^@ http://purl.uniprot.org/uniprot/A0A674GT18 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/A0A674H8M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59729:WNT5A ^@ http://purl.uniprot.org/uniprot/H0Z9G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59729:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A674H1L5|||http://purl.uniprot.org/uniprot/H0ZT29 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/59729:PUS3 ^@ http://purl.uniprot.org/uniprot/A0A674GFE4 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/59729:LOC100224416 ^@ http://purl.uniprot.org/uniprot/B5FYW5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:FRK ^@ http://purl.uniprot.org/uniprot/H0ZNZ2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59729:AHCY ^@ http://purl.uniprot.org/uniprot/A0A674HNW8 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/59729:NOL6 ^@ http://purl.uniprot.org/uniprot/H0YTW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||nucleolus http://togogenome.org/gene/59729:PDIK1L ^@ http://purl.uniprot.org/uniprot/A0A674GU31 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59729:PKNOX1 ^@ http://purl.uniprot.org/uniprot/A0A674HJG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/59729:TOB1 ^@ http://purl.uniprot.org/uniprot/H0ZG06 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/59729:GLO1 ^@ http://purl.uniprot.org/uniprot/B5FYL6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/59729:GRIN1 ^@ http://purl.uniprot.org/uniprot/Q6DUV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/59729:LOC121468025 ^@ http://purl.uniprot.org/uniprot/A0A674GU45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59729:TMEM189 ^@ http://purl.uniprot.org/uniprot/B5FY07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase CarF family.|||Membrane http://togogenome.org/gene/59729:MRPS6 ^@ http://purl.uniprot.org/uniprot/B5FYX3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/59729:RBP1 ^@ http://purl.uniprot.org/uniprot/H0Z405 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59729:KCNK2 ^@ http://purl.uniprot.org/uniprot/A0A674H2Z8|||http://purl.uniprot.org/uniprot/A0A674HAW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/59729:C4H20orf27 ^@ http://purl.uniprot.org/uniprot/B5FX50 ^@ Function|||Similarity ^@ Belongs to the ADISSP family.|||May be involved in thermogenesis and glucose homeostasis. http://togogenome.org/gene/59729:POLR2D ^@ http://purl.uniprot.org/uniprot/B5FZ31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/59729:EIF2B5 ^@ http://purl.uniprot.org/uniprot/H0ZIK9 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/59729:COX7B ^@ http://purl.uniprot.org/uniprot/B5G416 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:AFF2 ^@ http://purl.uniprot.org/uniprot/A0A674G973 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/59729:GABPA ^@ http://purl.uniprot.org/uniprot/H0ZTL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59729:RPL37A ^@ http://purl.uniprot.org/uniprot/H0Z3V9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/59729:N6AMT1 ^@ http://purl.uniprot.org/uniprot/A0A674H854 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/59729:LOC100228865 ^@ http://purl.uniprot.org/uniprot/H1A527 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59729:PPA1 ^@ http://purl.uniprot.org/uniprot/B5KFF6 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/59729:TSPO ^@ http://purl.uniprot.org/uniprot/H0ZP63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/59729:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A674GDA7|||http://purl.uniprot.org/uniprot/A0A674H3P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/59729:TRMT6 ^@ http://purl.uniprot.org/uniprot/H0YVE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/59729:SEC13 ^@ http://purl.uniprot.org/uniprot/H0ZJL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/59729:KIF11 ^@ http://purl.uniprot.org/uniprot/H0ZF48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.|||spindle pole http://togogenome.org/gene/59729:NSG2 ^@ http://purl.uniprot.org/uniprot/B5G2X4 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/59729:CZH9orf64 ^@ http://purl.uniprot.org/uniprot/H0YY71 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/59729:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/A0A674GXM7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59729:LOC751995 ^@ http://purl.uniprot.org/uniprot/H0Z779 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A674H3I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/59729:SEMA6A ^@ http://purl.uniprot.org/uniprot/H1A4L4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:NDUFA10 ^@ http://purl.uniprot.org/uniprot/B5G1H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix http://togogenome.org/gene/59729:LOC100220412 ^@ http://purl.uniprot.org/uniprot/H0YUD8 ^@ Similarity ^@ Belongs to the avidin/streptavidin family. http://togogenome.org/gene/59729:KEG28_p12 ^@ http://purl.uniprot.org/uniprot/Q27GW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:PKIB ^@ http://purl.uniprot.org/uniprot/A0A674H8D2 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/59729:TPM4 ^@ http://purl.uniprot.org/uniprot/B5FYX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/59729:UBE2D1 ^@ http://purl.uniprot.org/uniprot/H0Z408 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59729:RPSA ^@ http://purl.uniprot.org/uniprot/B5FXT6 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/59729:TAAR1 ^@ http://purl.uniprot.org/uniprot/H0ZMX8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:ADRA1D ^@ http://purl.uniprot.org/uniprot/A0A674GXD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/59729:ATP5ME ^@ http://purl.uniprot.org/uniprot/B5FYN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase e subunit family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:PYROXD1 ^@ http://purl.uniprot.org/uniprot/A0A674GDI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.|||sarcomere http://togogenome.org/gene/59729:LOC100217866 ^@ http://purl.uniprot.org/uniprot/H0Z576 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:HGD ^@ http://purl.uniprot.org/uniprot/H0ZT23 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/59729:LOC100225898 ^@ http://purl.uniprot.org/uniprot/A0A674H7C0 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A674HC91|||http://purl.uniprot.org/uniprot/A0A674HUY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.|||synaptosome http://togogenome.org/gene/59729:ORAI2 ^@ http://purl.uniprot.org/uniprot/A0A674GJE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/59729:SLC5A7 ^@ http://purl.uniprot.org/uniprot/H0ZHD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/59729:ARPC1A ^@ http://purl.uniprot.org/uniprot/H0ZB85 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/59729:HINT1 ^@ http://purl.uniprot.org/uniprot/B5G2K2 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/59729:C3H6orf58 ^@ http://purl.uniprot.org/uniprot/H0ZND9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/59729:NSA2 ^@ http://purl.uniprot.org/uniprot/B5FXH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/59729:EPS8 ^@ http://purl.uniprot.org/uniprot/A0A674H4H1 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/59729:LAPTM4A ^@ http://purl.uniprot.org/uniprot/B5G1Q1|||http://purl.uniprot.org/uniprot/B5G1Q5 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/59729:DUS4L ^@ http://purl.uniprot.org/uniprot/H0YY40 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/59729:TMEM200C ^@ http://purl.uniprot.org/uniprot/A0A674HDU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/59729:ACOX2 ^@ http://purl.uniprot.org/uniprot/H0ZG19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/59729:KLHL15 ^@ http://purl.uniprot.org/uniprot/A0A674HNR2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ARHGDIG ^@ http://purl.uniprot.org/uniprot/B5G151 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/59729:CACNG2 ^@ http://purl.uniprot.org/uniprot/H0ZKD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/59729:UGDH ^@ http://purl.uniprot.org/uniprot/H0ZET5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/59729:LSM4 ^@ http://purl.uniprot.org/uniprot/B5KFU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/59729:CASQ2 ^@ http://purl.uniprot.org/uniprot/H0ZT41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/59729:CAB39L ^@ http://purl.uniprot.org/uniprot/H0ZPJ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/59729:RPS26 ^@ http://purl.uniprot.org/uniprot/B5FYD8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/59729:DUSP6 ^@ http://purl.uniprot.org/uniprot/H0ZCI9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/59729:TMEM120B ^@ http://purl.uniprot.org/uniprot/B5KFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM120 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/59729:LOC100222415 ^@ http://purl.uniprot.org/uniprot/H0ZHD0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59729:KARS1 ^@ http://purl.uniprot.org/uniprot/A0A674H7G9|||http://purl.uniprot.org/uniprot/H0ZDN2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/59729:CEBPA ^@ http://purl.uniprot.org/uniprot/H0ZGP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/59729:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A674HBW7 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/59729:DDRGK1 ^@ http://purl.uniprot.org/uniprot/H0ZL58 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/59729:RPL39 ^@ http://purl.uniprot.org/uniprot/B5FY19 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/59729:BBS2 ^@ http://purl.uniprot.org/uniprot/H0Z855 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/59729:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A674GJD3 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/59729:CRYBB1 ^@ http://purl.uniprot.org/uniprot/H0ZBN7 ^@ Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/59729:SOX14 ^@ http://purl.uniprot.org/uniprot/H0Z8W5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:LOC105758847 ^@ http://purl.uniprot.org/uniprot/A0A674H6Y7 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:PROC ^@ http://purl.uniprot.org/uniprot/H0ZAX9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59729:PLA2G12A ^@ http://purl.uniprot.org/uniprot/H0Z147 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59729:PSMB4 ^@ http://purl.uniprot.org/uniprot/B5G4G8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/59729:HMGB3 ^@ http://purl.uniprot.org/uniprot/A0A674GRJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/59729:RPS11 ^@ http://purl.uniprot.org/uniprot/B5FX82 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/59729:LOC101233192 ^@ http://purl.uniprot.org/uniprot/H0Z5X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/59729:LOC100232776 ^@ http://purl.uniprot.org/uniprot/H0Z842 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59729:SLCO2A1 ^@ http://purl.uniprot.org/uniprot/H0Z8E7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59729:MLEC ^@ http://purl.uniprot.org/uniprot/B5FXH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the malectin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:RPS25 ^@ http://purl.uniprot.org/uniprot/B5FX78 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS25 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/59729:HOXA13 ^@ http://purl.uniprot.org/uniprot/H0YXI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/59729:DBX2 ^@ http://purl.uniprot.org/uniprot/B5FX96 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:TP53RK ^@ http://purl.uniprot.org/uniprot/B5G025 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/59729:CDC34 ^@ http://purl.uniprot.org/uniprot/H0YQR3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59729:PDCL ^@ http://purl.uniprot.org/uniprot/H0Z924 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/59729:RIOK2 ^@ http://purl.uniprot.org/uniprot/H0YSK4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/59729:CA7 ^@ http://purl.uniprot.org/uniprot/H0ZHF2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59729:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A674GGR1 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/59729:MAFF ^@ http://purl.uniprot.org/uniprot/A0A674HER0 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/59729:ECHS1 ^@ http://purl.uniprot.org/uniprot/B5FXI3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/59729:ZDHHC14 ^@ http://purl.uniprot.org/uniprot/A0A674HU90|||http://purl.uniprot.org/uniprot/H0ZLH6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59729:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A674H2G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:MAGOH ^@ http://purl.uniprot.org/uniprot/B5KFL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/59729:PPP4R3A ^@ http://purl.uniprot.org/uniprot/A0A674GCU8 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/59729:RPS14 ^@ http://purl.uniprot.org/uniprot/B5G2V9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/59729:NDUFAB1 ^@ http://purl.uniprot.org/uniprot/B5G0K6 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/59729:TFAP2C ^@ http://purl.uniprot.org/uniprot/H0ZDH9 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/59729:CRYAA ^@ http://purl.uniprot.org/uniprot/A0A674HC43 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/59729:NMBR ^@ http://purl.uniprot.org/uniprot/H0ZL07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59729:RPL9 ^@ http://purl.uniprot.org/uniprot/B5FYQ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/59729:LOC100190505 ^@ http://purl.uniprot.org/uniprot/B5G3Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||cytoskeleton http://togogenome.org/gene/59729:CCDC126 ^@ http://purl.uniprot.org/uniprot/A0A674GUD3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59729:NDRG3 ^@ http://purl.uniprot.org/uniprot/A0A674HPF7 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/59729:UTP11 ^@ http://purl.uniprot.org/uniprot/B5FZT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/59729:CSTF2 ^@ http://purl.uniprot.org/uniprot/A0A674G7F3|||http://purl.uniprot.org/uniprot/A0A674GKM5|||http://purl.uniprot.org/uniprot/A0A674H008 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:CSRNP1 ^@ http://purl.uniprot.org/uniprot/A0A674HNM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/59729:MID1IP1 ^@ http://purl.uniprot.org/uniprot/B5FZW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59729:LOC100226706 ^@ http://purl.uniprot.org/uniprot/A0A674H9I1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:KCNJ4 ^@ http://purl.uniprot.org/uniprot/A0A674HE84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/59729:MAFK ^@ http://purl.uniprot.org/uniprot/A0A674HV58 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/59729:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/A0A674GCR5|||http://purl.uniprot.org/uniprot/A0A674HP77 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/59729:TUBB6 ^@ http://purl.uniprot.org/uniprot/A0A674GUH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59729:ASCC1 ^@ http://purl.uniprot.org/uniprot/A0A674HCG5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59729:LOC105758845 ^@ http://purl.uniprot.org/uniprot/A0A674GDG2 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:GDNF ^@ http://purl.uniprot.org/uniprot/A0A674GT80|||http://purl.uniprot.org/uniprot/A0A674H3U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/59729:VPS29 ^@ http://purl.uniprot.org/uniprot/B5G2X5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/59729:DCTN5 ^@ http://purl.uniprot.org/uniprot/B5G4S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/59729:HOMER1 ^@ http://purl.uniprot.org/uniprot/H0YZU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/59729:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A674HJA5 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/59729:MRPL51 ^@ http://purl.uniprot.org/uniprot/B5G129 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family.|||Mitochondrion http://togogenome.org/gene/59729:UCK2 ^@ http://purl.uniprot.org/uniprot/B5FYF5 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/59729:PARK7 ^@ http://purl.uniprot.org/uniprot/B5G3Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/59729:LOC100190429 ^@ http://purl.uniprot.org/uniprot/B5G208 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/59729:KEG28_p08 ^@ http://purl.uniprot.org/uniprot/Q27GW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:LOC100223493 ^@ http://purl.uniprot.org/uniprot/H0ZG86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:PFDN4 ^@ http://purl.uniprot.org/uniprot/B5FYT2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/59729:IMMP1L ^@ http://purl.uniprot.org/uniprot/B5FZA7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/59729:NPY4R2 ^@ http://purl.uniprot.org/uniprot/H0ZC49 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:LOC100221679 ^@ http://purl.uniprot.org/uniprot/A0A674HLL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/59729:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A674GAG8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59729:RPF2 ^@ http://purl.uniprot.org/uniprot/B5FY82|||http://purl.uniprot.org/uniprot/H0ZP68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/59729:B3GNT7 ^@ http://purl.uniprot.org/uniprot/B5FXB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59729:ORC4 ^@ http://purl.uniprot.org/uniprot/A0A674GGH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/59729:KRT222 ^@ http://purl.uniprot.org/uniprot/H0YVW4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59729:RPS20 ^@ http://purl.uniprot.org/uniprot/H0ZLG5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/59729:SCAMP5 ^@ http://purl.uniprot.org/uniprot/B5G477 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/59729:MAD1L1 ^@ http://purl.uniprot.org/uniprot/A0A674HL44|||http://purl.uniprot.org/uniprot/H0ZCY8 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/59729:FRG1 ^@ http://purl.uniprot.org/uniprot/B5G1N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/59729:LDAF1 ^@ http://purl.uniprot.org/uniprot/B5G2Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/59729:RPS23 ^@ http://purl.uniprot.org/uniprot/B5FZK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/59729:TBCA ^@ http://purl.uniprot.org/uniprot/B5G0F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/59729:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A674HVI8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/59729:VDAC3 ^@ http://purl.uniprot.org/uniprot/B5G3N8 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/59729:SLC25A48 ^@ http://purl.uniprot.org/uniprot/H0YSM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59729:LOC100222166 ^@ http://purl.uniprot.org/uniprot/H0Z5Y4 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/59729:NAPB ^@ http://purl.uniprot.org/uniprot/H0ZAV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/59729:H3F3B ^@ http://purl.uniprot.org/uniprot/B5FZ57 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59729:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A674GY35 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ERG28 ^@ http://purl.uniprot.org/uniprot/B5G3Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:SNW1 ^@ http://purl.uniprot.org/uniprot/A0A674H4B1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/59729:TLR4 ^@ http://purl.uniprot.org/uniprot/B6D4V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/59729:IL1R1 ^@ http://purl.uniprot.org/uniprot/H0ZHY3 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/59729:PPIL4 ^@ http://purl.uniprot.org/uniprot/H0ZK72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59729:HTRA3 ^@ http://purl.uniprot.org/uniprot/H0ZJ14 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/59729:EFEMP1 ^@ http://purl.uniprot.org/uniprot/H0Z947 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:SCT ^@ http://purl.uniprot.org/uniprot/F2YI30 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/59729:LOC100219287 ^@ http://purl.uniprot.org/uniprot/H0ZNA7 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59729:UBE2I ^@ http://purl.uniprot.org/uniprot/B5FZW7|||http://purl.uniprot.org/uniprot/H0ZH10 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59729:POP5 ^@ http://purl.uniprot.org/uniprot/A0A674HMU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/59729:LCA5 ^@ http://purl.uniprot.org/uniprot/H0ZQR6 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/59729:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A674GVC9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/59729:FDFT1 ^@ http://purl.uniprot.org/uniprot/A0A674HU74 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/59729:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A674GYF5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59729:POLR2I ^@ http://purl.uniprot.org/uniprot/B5FX75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/59729:RPL32 ^@ http://purl.uniprot.org/uniprot/B5G0L6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/59729:GMPPA ^@ http://purl.uniprot.org/uniprot/A0A674GRC0|||http://purl.uniprot.org/uniprot/A0A674HLF9 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/59729:EIF3J ^@ http://purl.uniprot.org/uniprot/B5G0D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit J family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/59729:ATP6V0B ^@ http://purl.uniprot.org/uniprot/B5G4H9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||clathrin-coated vesicle membrane http://togogenome.org/gene/59729:GTF2E1 ^@ http://purl.uniprot.org/uniprot/A0A674H399 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/59729:DGCR2 ^@ http://purl.uniprot.org/uniprot/H0ZF22 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59729:ATP5PF ^@ http://purl.uniprot.org/uniprot/B5G0F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/59729:GJA1 ^@ http://purl.uniprot.org/uniprot/H0ZNN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59729:INTS7 ^@ http://purl.uniprot.org/uniprot/H0YY53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/59729:ADCYAP1 ^@ http://purl.uniprot.org/uniprot/A0A674GJE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/59729:AP3S2 ^@ http://purl.uniprot.org/uniprot/B5G417 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/59729:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A674HDN1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/59729:SRP14 ^@ http://purl.uniprot.org/uniprot/B5FYF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/59729:TH ^@ http://purl.uniprot.org/uniprot/H0ZG94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region http://togogenome.org/gene/59729:RC3H2 ^@ http://purl.uniprot.org/uniprot/H0Z973 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/59729:TAT ^@ http://purl.uniprot.org/uniprot/A0A674G907 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/59729:AARS2 ^@ http://purl.uniprot.org/uniprot/H0ZC41 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/59729:RPLP0 ^@ http://purl.uniprot.org/uniprot/H0ZGQ3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/59729:ANXA6 ^@ http://purl.uniprot.org/uniprot/H0YRC2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome http://togogenome.org/gene/59729:LOC100225918 ^@ http://purl.uniprot.org/uniprot/K9J9P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/59729:IDI1 ^@ http://purl.uniprot.org/uniprot/B5G0X6 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/59729:PRPH2 ^@ http://purl.uniprot.org/uniprot/A0A674H5M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/59729:STEAP2 ^@ http://purl.uniprot.org/uniprot/A0A674GY24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/59729:RPL21 ^@ http://purl.uniprot.org/uniprot/B5FY47 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/59729:PSMC3IP ^@ http://purl.uniprot.org/uniprot/B5FZP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/59729:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/B5FXZ3 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/59729:SIX6 ^@ http://purl.uniprot.org/uniprot/H0ZRY7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:ADI1 ^@ http://purl.uniprot.org/uniprot/H0ZRX0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Cell membrane|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/59729:UBE3A ^@ http://purl.uniprot.org/uniprot/H0ZJ61 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/59729:DEGS1 ^@ http://purl.uniprot.org/uniprot/A0A674GIG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:WDFY1 ^@ http://purl.uniprot.org/uniprot/H0ZC67 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/59729:POLR3B ^@ http://purl.uniprot.org/uniprot/A0A674GK25 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/59729:PHKB ^@ http://purl.uniprot.org/uniprot/A0A674HQQ4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/59729:LOC100226912 ^@ http://purl.uniprot.org/uniprot/A0A674GKX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/59729:LOC100219548 ^@ http://purl.uniprot.org/uniprot/H0ZM34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59729:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/B5G3I3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59729:LOC100223776 ^@ http://purl.uniprot.org/uniprot/A0A674GYF4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59729:PHYKPL ^@ http://purl.uniprot.org/uniprot/H1A1R5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/59729:MEAF6 ^@ http://purl.uniprot.org/uniprot/B5FZP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.|||Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.|||kinetochore|||nucleolus http://togogenome.org/gene/59729:ATP5MC3 ^@ http://purl.uniprot.org/uniprot/H0ZF13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/59729:LOC100228523 ^@ http://purl.uniprot.org/uniprot/B5G1T5 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/59729:AQR ^@ http://purl.uniprot.org/uniprot/A0A674H803 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWF11 family.|||Nucleus http://togogenome.org/gene/59729:LOC100221212 ^@ http://purl.uniprot.org/uniprot/A0A674HL91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/59729:MTMR12 ^@ http://purl.uniprot.org/uniprot/A0A674GG04 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/59729:LOC100223925 ^@ http://purl.uniprot.org/uniprot/A0A674GQN3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane http://togogenome.org/gene/59729:FGF9 ^@ http://purl.uniprot.org/uniprot/A0A674GK86 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59729:LOC100218025 ^@ http://purl.uniprot.org/uniprot/H0ZDP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/59729:ITGAV ^@ http://purl.uniprot.org/uniprot/H0ZLJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/59729:MID1 ^@ http://purl.uniprot.org/uniprot/A0A674GF72 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59729:ONECUT1 ^@ http://purl.uniprot.org/uniprot/H0Z8B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/59729:LOC100221285 ^@ http://purl.uniprot.org/uniprot/H0ZGH6 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/59729:LOC105758849 ^@ http://purl.uniprot.org/uniprot/H1A5Q2 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59729:COX7A2 ^@ http://purl.uniprot.org/uniprot/B5FXU7|||http://purl.uniprot.org/uniprot/B5FXU8 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/59729:GGACT ^@ http://purl.uniprot.org/uniprot/A0A674HVZ4 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. http://togogenome.org/gene/59729:SH3RF1 ^@ http://purl.uniprot.org/uniprot/H0Z6T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3RF family.|||lamellipodium|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/59729:CYFIP2 ^@ http://purl.uniprot.org/uniprot/H0YQV5 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/59729:CYCS ^@ http://purl.uniprot.org/uniprot/B5FZX0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/59729:GPR18 ^@ http://purl.uniprot.org/uniprot/H1A584 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59729:FGFBP2 ^@ http://purl.uniprot.org/uniprot/H0ZHK0 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/59729:NR1H3 ^@ http://purl.uniprot.org/uniprot/A0A674GLK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/59729:LOC100230549 ^@ http://purl.uniprot.org/uniprot/H0Z9L0 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/59729:SATB1 ^@ http://purl.uniprot.org/uniprot/H0YYC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/59729:RAP2C ^@ http://purl.uniprot.org/uniprot/H0YXT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/59729:SNTG1 ^@ http://purl.uniprot.org/uniprot/H0ZKZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/59729:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A674HBJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/59729:TIMM21 ^@ http://purl.uniprot.org/uniprot/A0A674HQG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/59729:NECAP1 ^@ http://purl.uniprot.org/uniprot/A0A674GM92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/59729:PACSIN2 ^@ http://purl.uniprot.org/uniprot/A0A674HKS7|||http://purl.uniprot.org/uniprot/A0A674HP48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/59729:STMN2 ^@ http://purl.uniprot.org/uniprot/B5KFG0 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/59729:NDUFS5 ^@ http://purl.uniprot.org/uniprot/B5G0Z7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59729:GCLC ^@ http://purl.uniprot.org/uniprot/H0ZRK0 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/59729:MYF6 ^@ http://purl.uniprot.org/uniprot/H0ZBL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:SEC11C ^@ http://purl.uniprot.org/uniprot/B5FZU1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59729:OPTN ^@ http://purl.uniprot.org/uniprot/A0A674GG47|||http://purl.uniprot.org/uniprot/A0A674GM34 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/59729:CHUK ^@ http://purl.uniprot.org/uniprot/H0Z2P4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59729:RPS15 ^@ http://purl.uniprot.org/uniprot/B5FXX7 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS19 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/59729:GOLPH3 ^@ http://purl.uniprot.org/uniprot/H0YUJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/59729:FGF20 ^@ http://purl.uniprot.org/uniprot/H0ZAB7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59729:SCOC ^@ http://purl.uniprot.org/uniprot/A0A674HBG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/59729:RAMP3 ^@ http://purl.uniprot.org/uniprot/A0A674GA25 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/59729:HHATL ^@ http://purl.uniprot.org/uniprot/H0YPS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59729:SMYD2 ^@ http://purl.uniprot.org/uniprot/H0YXN3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.|||cytosol http://togogenome.org/gene/59729:PJVK ^@ http://purl.uniprot.org/uniprot/H0ZFV2 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/59729:FABP5 ^@ http://purl.uniprot.org/uniprot/B5FXG2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59729:SIX2 ^@ http://purl.uniprot.org/uniprot/H0Z093 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59729:TPM2 ^@ http://purl.uniprot.org/uniprot/B5FZA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/59729:CALHM1 ^@ http://purl.uniprot.org/uniprot/H0ZJ78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane