http://togogenome.org/gene/634498:MRU_RS09610 ^@ http://purl.uniprot.org/uniprot/D3E046 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrB family.|||Cell membrane|||Membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/634498:MRU_RS08400 ^@ http://purl.uniprot.org/uniprot/D3DYY0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/634498:MRU_RS03035 ^@ http://purl.uniprot.org/uniprot/D3E1N3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS01690 ^@ http://purl.uniprot.org/uniprot/D3E005 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/634498:MRU_RS08935 ^@ http://purl.uniprot.org/uniprot/D3DZG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS02455 ^@ http://purl.uniprot.org/uniprot/D3E151 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/634498:MRU_RS02450 ^@ http://purl.uniprot.org/uniprot/D3E150 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Membrane http://togogenome.org/gene/634498:MRU_RS00460 ^@ http://purl.uniprot.org/uniprot/D3DYM1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS09130 ^@ http://purl.uniprot.org/uniprot/D3DZJ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/634498:MRU_RS06710 ^@ http://purl.uniprot.org/uniprot/D3E3T0 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/634498:MRU_RS04675 ^@ http://purl.uniprot.org/uniprot/D3E2L7 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/634498:MRU_RS04175 ^@ http://purl.uniprot.org/uniprot/D3E2B7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS00635 ^@ http://purl.uniprot.org/uniprot/D3DYQ7 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/634498:MRU_RS01980 ^@ http://purl.uniprot.org/uniprot/D3E0J4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/634498:MRU_RS05490 ^@ http://purl.uniprot.org/uniprot/D3E331 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/634498:MRU_RS04965 ^@ http://purl.uniprot.org/uniprot/D3E2S6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS08425 ^@ http://purl.uniprot.org/uniprot/D3DYY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS08440 ^@ http://purl.uniprot.org/uniprot/D3DYY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS08475 ^@ http://purl.uniprot.org/uniprot/D3DYZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/634498:MRU_RS04820 ^@ http://purl.uniprot.org/uniprot/D3E2P6 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/634498:MRU_RS00640 ^@ http://purl.uniprot.org/uniprot/D3DYQ8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/634498:MRU_RS04655 ^@ http://purl.uniprot.org/uniprot/D3E2L3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/634498:MRU_RS09615 ^@ http://purl.uniprot.org/uniprot/D3E047 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrC family.|||Cell membrane|||Membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/634498:MRU_RS04645 ^@ http://purl.uniprot.org/uniprot/D3E2L1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS10100 ^@ http://purl.uniprot.org/uniprot/D3E0E3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS05100 ^@ http://purl.uniprot.org/uniprot/D3E2V4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS02740 ^@ http://purl.uniprot.org/uniprot/D3E1A9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS10305 ^@ http://purl.uniprot.org/uniprot/D3E0S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/634498:MRU_RS04970 ^@ http://purl.uniprot.org/uniprot/D3E2S7 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS10290 ^@ http://purl.uniprot.org/uniprot/D3E0S4 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS09595 ^@ http://purl.uniprot.org/uniprot/D3E043 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrG family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/634498:MRU_RS08095 ^@ http://purl.uniprot.org/uniprot/D3E4S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/634498:MRU_RS07380 ^@ http://purl.uniprot.org/uniprot/D3E465 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS02690 ^@ http://purl.uniprot.org/uniprot/D3E199 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/634498:MRU_RS06360 ^@ http://purl.uniprot.org/uniprot/D3E3L0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS05525 ^@ http://purl.uniprot.org/uniprot/D3E339 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS00645 ^@ http://purl.uniprot.org/uniprot/D3DYQ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/634498:MRU_RS06735 ^@ http://purl.uniprot.org/uniprot/D3E3T5 ^@ Similarity ^@ Belongs to the UPF0440 family. http://togogenome.org/gene/634498:MRU_RS10545 ^@ http://purl.uniprot.org/uniprot/D3E0X4 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS03415 ^@ http://purl.uniprot.org/uniprot/D3E1W2 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/634498:MRU_RS00075 ^@ http://purl.uniprot.org/uniprot/D3E4H1 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/634498:MRU_RS02470 ^@ http://purl.uniprot.org/uniprot/D3E154 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/634498:MRU_RS02020 ^@ http://purl.uniprot.org/uniprot/D3E0K2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS11120 ^@ http://purl.uniprot.org/uniprot/D3E1I0 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/634498:MRU_RS04835 ^@ http://purl.uniprot.org/uniprot/D3E2P9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/634498:MRU_RS10605 ^@ http://purl.uniprot.org/uniprot/D3E0Y5 ^@ Similarity ^@ Belongs to the UPF0285 family. http://togogenome.org/gene/634498:MRU_RS08360 ^@ http://purl.uniprot.org/uniprot/D3DYX2 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/634498:MRU_RS08600 ^@ http://purl.uniprot.org/uniprot/D3DZ19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS03315 ^@ http://purl.uniprot.org/uniprot/D3E1U2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.|||Homotrimer. http://togogenome.org/gene/634498:MRU_RS07610 ^@ http://purl.uniprot.org/uniprot/D3E4B1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS07085 ^@ http://purl.uniprot.org/uniprot/D3E407 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/634498:MRU_RS02380 ^@ http://purl.uniprot.org/uniprot/D3E137 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/634498:MRU_RS06740 ^@ http://purl.uniprot.org/uniprot/D3E3T6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/634498:MRU_RS02075 ^@ http://purl.uniprot.org/uniprot/D3E0L3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS08350 ^@ http://purl.uniprot.org/uniprot/D3DYX0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/634498:MRU_RS09770 ^@ http://purl.uniprot.org/uniprot/D3E078 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS09620 ^@ http://purl.uniprot.org/uniprot/D3E048 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrD family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/634498:MRU_RS04360 ^@ http://purl.uniprot.org/uniprot/D3E2F4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/634498:MRU_RS02280 ^@ http://purl.uniprot.org/uniprot/D3E0Q4 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/634498:MRU_RS00775 ^@ http://purl.uniprot.org/uniprot/D3DYT5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS00890 ^@ http://purl.uniprot.org/uniprot/D3DYV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/634498:MRU_RS07550 ^@ http://purl.uniprot.org/uniprot/D3E499 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS08730 ^@ http://purl.uniprot.org/uniprot/D3DZ46 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/634498:MRU_RS10140 ^@ http://purl.uniprot.org/uniprot/D3E0F1 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/634498:MRU_RS03435 ^@ http://purl.uniprot.org/uniprot/D3E1W6 ^@ Similarity ^@ Belongs to the tRNA(His) guanylyltransferase family. http://togogenome.org/gene/634498:MRU_RS09755 ^@ http://purl.uniprot.org/uniprot/D3E075 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/634498:MRU_RS02670 ^@ http://purl.uniprot.org/uniprot/D3E194 ^@ Function|||Similarity ^@ Belongs to the HMD family.|||Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. http://togogenome.org/gene/634498:MRU_RS10220 ^@ http://purl.uniprot.org/uniprot/D3E0G0 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/634498:MRU_RS08235 ^@ http://purl.uniprot.org/uniprot/D3E4V1 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/634498:MRU_RS04230 ^@ http://purl.uniprot.org/uniprot/D3E2C7 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation. http://togogenome.org/gene/634498:MRU_RS07105 ^@ http://purl.uniprot.org/uniprot/D3E411 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/634498:MRU_RS06340 ^@ http://purl.uniprot.org/uniprot/D3E3K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS03325 ^@ http://purl.uniprot.org/uniprot/D3E1U4 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/634498:MRU_RS03925 ^@ http://purl.uniprot.org/uniprot/D3E266 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/634498:MRU_RS07065 ^@ http://purl.uniprot.org/uniprot/D3E403 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS07790 ^@ http://purl.uniprot.org/uniprot/D3E4E9 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/634498:MRU_RS12055 ^@ http://purl.uniprot.org/uniprot/D3E2A6 ^@ Similarity ^@ Belongs to the HdrC family. http://togogenome.org/gene/634498:MRU_RS03405 ^@ http://purl.uniprot.org/uniprot/D3E1W0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS10410 ^@ http://purl.uniprot.org/uniprot/D3E0U5 ^@ Similarity ^@ Belongs to the UPF0305 family. http://togogenome.org/gene/634498:MRU_RS09550 ^@ http://purl.uniprot.org/uniprot/D3E034 ^@ Similarity ^@ Belongs to the MvhD/VhuD family. http://togogenome.org/gene/634498:MRU_RS05385 ^@ http://purl.uniprot.org/uniprot/D3E310 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS04415 ^@ http://purl.uniprot.org/uniprot/D3E2G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/634498:MRU_RS09445 ^@ http://purl.uniprot.org/uniprot/D3DZQ9 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/634498:MRU_RS02530 ^@ http://purl.uniprot.org/uniprot/D3E166 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/634498:MRU_RS09330 ^@ http://purl.uniprot.org/uniprot/D3DZN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/634498:MRU_RS00450 ^@ http://purl.uniprot.org/uniprot/D3DYL9 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent. http://togogenome.org/gene/634498:MRU_RS09640 ^@ http://purl.uniprot.org/uniprot/D3E052 ^@ Subunit ^@ MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known. http://togogenome.org/gene/634498:MRU_RS02325 ^@ http://purl.uniprot.org/uniprot/D3E127 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/634498:MRU_RS04320 ^@ http://purl.uniprot.org/uniprot/D3E2E6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/634498:MRU_RS02025 ^@ http://purl.uniprot.org/uniprot/D3E0K3 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/634498:MRU_RS03490 ^@ http://purl.uniprot.org/uniprot/D3E1X8 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/634498:MRU_RS10990 ^@ http://purl.uniprot.org/uniprot/D3E1F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS06365 ^@ http://purl.uniprot.org/uniprot/D3E3L1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS02335 ^@ http://purl.uniprot.org/uniprot/D3E129 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/634498:MRU_RS03565 ^@ http://purl.uniprot.org/uniprot/D3E1Z3 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/634498:MRU_RS09820 ^@ http://purl.uniprot.org/uniprot/D3E088 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase IV family.|||Binds 1 Fe(2+) ion per subunit.|||Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS08390 ^@ http://purl.uniprot.org/uniprot/D3DYX8 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/634498:MRU_RS07440 ^@ http://purl.uniprot.org/uniprot/D3E477 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/634498:MRU_RS05975 ^@ http://purl.uniprot.org/uniprot/D3E3D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/634498:MRU_RS10085 ^@ http://purl.uniprot.org/uniprot/D3E0E0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/634498:MRU_RS04530 ^@ http://purl.uniprot.org/uniprot/D3E2I8 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/634498:MRU_RS08740 ^@ http://purl.uniprot.org/uniprot/D3DZ48 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/634498:MRU_RS02410 ^@ http://purl.uniprot.org/uniprot/D3E143 ^@ Similarity ^@ Belongs to the archaeosine synthase type 1 family. http://togogenome.org/gene/634498:MRU_RS04365 ^@ http://purl.uniprot.org/uniprot/D3E2F5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/634498:MRU_RS01075 ^@ http://purl.uniprot.org/uniprot/D3DZB1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/634498:MRU_RS10365 ^@ http://purl.uniprot.org/uniprot/D3E0T8 ^@ Similarity ^@ Belongs to the FrhG family. http://togogenome.org/gene/634498:MRU_RS04745 ^@ http://purl.uniprot.org/uniprot/D3E2N1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.|||Homodimer.|||Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate. http://togogenome.org/gene/634498:MRU_RS02700 ^@ http://purl.uniprot.org/uniprot/D3E1A1 ^@ Similarity ^@ Belongs to the UPF0254 family. http://togogenome.org/gene/634498:MRU_RS01230 ^@ http://purl.uniprot.org/uniprot/D3DZC6 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/634498:MRU_RS04340 ^@ http://purl.uniprot.org/uniprot/D3E2F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/634498:MRU_RS02010 ^@ http://purl.uniprot.org/uniprot/D3E0K0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/634498:MRU_RS04355 ^@ http://purl.uniprot.org/uniprot/D3E2F3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS02085 ^@ http://purl.uniprot.org/uniprot/D3E0L5 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/634498:MRU_RS07275 ^@ http://purl.uniprot.org/uniprot/D3E445 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS01060 ^@ http://purl.uniprot.org/uniprot/D3DZA8 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/634498:MRU_RS09950 ^@ http://purl.uniprot.org/uniprot/D3E0B3 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/634498:MRU_RS00005 ^@ http://purl.uniprot.org/uniprot/D3E4F7 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/634498:MRU_RS07880 ^@ http://purl.uniprot.org/uniprot/D3E4M9 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/634498:MRU_RS04460 ^@ http://purl.uniprot.org/uniprot/D3E2H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiN family.|||Cell membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/634498:MRU_RS03915 ^@ http://purl.uniprot.org/uniprot/D3E264 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS02230 ^@ http://purl.uniprot.org/uniprot/D3E0P4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS10265 ^@ http://purl.uniprot.org/uniprot/D3E0R9 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS04335 ^@ http://purl.uniprot.org/uniprot/D3E2E9 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/634498:MRU_RS06350 ^@ http://purl.uniprot.org/uniprot/D3E3K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS00410 ^@ http://purl.uniprot.org/uniprot/D3DYL1 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS04450 ^@ http://purl.uniprot.org/uniprot/D3E2H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Part of an ABC transporter complex. Responsible for energy coupling to the transport system.|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/634498:MRU_RS10595 ^@ http://purl.uniprot.org/uniprot/D3E0Y3 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/634498:MRU_RS06525 ^@ http://purl.uniprot.org/uniprot/D3E3P4 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/634498:MRU_RS00770 ^@ http://purl.uniprot.org/uniprot/D3DYT4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/634498:MRU_RS00810 ^@ http://purl.uniprot.org/uniprot/D3DYU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/634498:MRU_RS09235 ^@ http://purl.uniprot.org/uniprot/D3DZL7 ^@ Function|||Similarity ^@ Belongs to the archaeal-type GTP cyclohydrolase family.|||Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. http://togogenome.org/gene/634498:MRU_RS05760 ^@ http://purl.uniprot.org/uniprot/D3E387 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/634498:MRU_RS01070 ^@ http://purl.uniprot.org/uniprot/D3DZB0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/634498:MRU_RS02830 ^@ http://purl.uniprot.org/uniprot/D3E1J6 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/634498:MRU_RS07095 ^@ http://purl.uniprot.org/uniprot/D3E409 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/634498:MRU_RS11115 ^@ http://purl.uniprot.org/uniprot/D3E1H9 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/634498:MRU_RS05070 ^@ http://purl.uniprot.org/uniprot/D3E2U7 ^@ Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS08805 ^@ http://purl.uniprot.org/uniprot/D3DZ61 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/634498:MRU_RS04310 ^@ http://purl.uniprot.org/uniprot/D3E2E4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/634498:MRU_RS09530 ^@ http://purl.uniprot.org/uniprot/D3DZS6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/634498:MRU_RS07390 ^@ http://purl.uniprot.org/uniprot/D3E467 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/634498:MRU_RS02555 ^@ http://purl.uniprot.org/uniprot/D3E171 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Binds 2 Mg(2+) or Mn(2+) ions per subunit.|||Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.|||Cell membrane http://togogenome.org/gene/634498:MRU_RS10750 ^@ http://purl.uniprot.org/uniprot/D3E113 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ModE family.|||Membrane http://togogenome.org/gene/634498:MRU_RS01885 ^@ http://purl.uniprot.org/uniprot/D3E0G4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS06190 ^@ http://purl.uniprot.org/uniprot/D3E3H6 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS08775 ^@ http://purl.uniprot.org/uniprot/D3DZ55 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/634498:MRU_RS04660 ^@ http://purl.uniprot.org/uniprot/D3E2L4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/634498:MRU_RS00870 ^@ http://purl.uniprot.org/uniprot/D3DYV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/634498:MRU_RS01795 ^@ http://purl.uniprot.org/uniprot/D3E026 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/634498:MRU_RS02720 ^@ http://purl.uniprot.org/uniprot/D3E1A5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS02240 ^@ http://purl.uniprot.org/uniprot/D3E0P6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrA family.|||Binds 1 5-hydroxybenzimidazolylcobamide group.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/634498:MRU_RS07750 ^@ http://purl.uniprot.org/uniprot/D3E4E1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS05660 ^@ http://purl.uniprot.org/uniprot/D3E367 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/634498:MRU_RS01955 ^@ http://purl.uniprot.org/uniprot/D3E0J0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/634498:MRU_RS11105 ^@ http://purl.uniprot.org/uniprot/D3E1H7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/634498:MRU_RS00815 ^@ http://purl.uniprot.org/uniprot/D3DYU4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/634498:MRU_RS00555 ^@ http://purl.uniprot.org/uniprot/D3DYP1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS10745 ^@ http://purl.uniprot.org/uniprot/D3E112 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS03350 ^@ http://purl.uniprot.org/uniprot/D3E1U9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS03610 ^@ http://purl.uniprot.org/uniprot/D3E201 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/634498:MRU_RS10485 ^@ http://purl.uniprot.org/uniprot/D3E0W2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dethiobiotin synthetase family.|||Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS05410 ^@ http://purl.uniprot.org/uniprot/D3E315 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/634498:MRU_RS03410 ^@ http://purl.uniprot.org/uniprot/D3E1W1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS03160 ^@ http://purl.uniprot.org/uniprot/D3E1Q8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/634498:MRU_RS00355 ^@ http://purl.uniprot.org/uniprot/D3DYK1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/634498:MRU_RS03150 ^@ http://purl.uniprot.org/uniprot/D3E1Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/634498:MRU_RS10670 ^@ http://purl.uniprot.org/uniprot/D3E0Z7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HCP family.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 hybrid [4Fe-2O-2S] cluster.|||Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS10660 ^@ http://purl.uniprot.org/uniprot/D3E0Z5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS05480 ^@ http://purl.uniprot.org/uniprot/D3E329 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS10650 ^@ http://purl.uniprot.org/uniprot/D3E0Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS05550 ^@ http://purl.uniprot.org/uniprot/D3E345 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/634498:MRU_RS05030 ^@ http://purl.uniprot.org/uniprot/D3E2T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS10515 ^@ http://purl.uniprot.org/uniprot/D3E0W8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/634498:MRU_RS09515 ^@ http://purl.uniprot.org/uniprot/D3DZS3 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/634498:MRU_RS00950 ^@ http://purl.uniprot.org/uniprot/D3DZ86 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS01040 ^@ http://purl.uniprot.org/uniprot/D3DZA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS05235 ^@ http://purl.uniprot.org/uniprot/D3E2Y1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS10475 ^@ http://purl.uniprot.org/uniprot/D3E0W0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.|||Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/634498:MRU_RS04880 ^@ http://purl.uniprot.org/uniprot/D3E2Q9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/634498:MRU_RS08255 ^@ http://purl.uniprot.org/uniprot/D3E4V6 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS04145 ^@ http://purl.uniprot.org/uniprot/D3E2B2 ^@ Function|||Similarity ^@ Belongs to the 2-phosphoglycerate kinase family.|||Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. http://togogenome.org/gene/634498:MRU_RS10560 ^@ http://purl.uniprot.org/uniprot/D3E0X7 ^@ Similarity ^@ Belongs to the UPF0284 family. http://togogenome.org/gene/634498:MRU_RS04255 ^@ http://purl.uniprot.org/uniprot/D3E2D2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/634498:MRU_RS03045 ^@ http://purl.uniprot.org/uniprot/D3E1N5 ^@ Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/634498:MRU_RS01705 ^@ http://purl.uniprot.org/uniprot/D3E008 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/634498:MRU_RS07545 ^@ http://purl.uniprot.org/uniprot/D3E498 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/634498:MRU_RS04400 ^@ http://purl.uniprot.org/uniprot/D3E2G2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/634498:MRU_RS09135 ^@ http://purl.uniprot.org/uniprot/D3DZJ6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/634498:MRU_RS07505 ^@ http://purl.uniprot.org/uniprot/D3E490 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/634498:MRU_RS06135 ^@ http://purl.uniprot.org/uniprot/D3E3G5 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/634498:MRU_RS10490 ^@ http://purl.uniprot.org/uniprot/D3E0W3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS08710 ^@ http://purl.uniprot.org/uniprot/D3DZ42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/634498:MRU_RS05715 ^@ http://purl.uniprot.org/uniprot/D3E378 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/634498:MRU_RS06380 ^@ http://purl.uniprot.org/uniprot/D3E3L4 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS02165 ^@ http://purl.uniprot.org/uniprot/D3E0N1 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/634498:MRU_RS04170 ^@ http://purl.uniprot.org/uniprot/D3E2B6 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/634498:MRU_RS01360 ^@ http://purl.uniprot.org/uniprot/D3DZT1 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS07280 ^@ http://purl.uniprot.org/uniprot/D3E446 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/634498:MRU_RS07690 ^@ http://purl.uniprot.org/uniprot/D3E4C9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/634498:MRU_RS03105 ^@ http://purl.uniprot.org/uniprot/D3E1P7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MntP (TC 9.B.29) family.|||Cell membrane|||Probably functions as a manganese efflux pump. http://togogenome.org/gene/634498:MRU_RS11265 ^@ http://purl.uniprot.org/uniprot/D3E0Y8 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/634498:MRU_RS03020 ^@ http://purl.uniprot.org/uniprot/D3E1N0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/634498:MRU_RS00845 ^@ http://purl.uniprot.org/uniprot/D3DYV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/634498:MRU_RS02055 ^@ http://purl.uniprot.org/uniprot/D3E0K9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/634498:MRU_RS01760 ^@ http://purl.uniprot.org/uniprot/D3E019 ^@ Function|||Similarity|||Subunit ^@ Belongs to the FwdB family.|||Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.|||This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG. http://togogenome.org/gene/634498:MRU_RS03235 ^@ http://purl.uniprot.org/uniprot/D3E1S5 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/634498:MRU_RS04570 ^@ http://purl.uniprot.org/uniprot/D3E2J6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/634498:MRU_RS09745 ^@ http://purl.uniprot.org/uniprot/D3E073 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/634498:MRU_RS08420 ^@ http://purl.uniprot.org/uniprot/D3DYY4 ^@ Cofactor|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/634498:MRU_RS05670 ^@ http://purl.uniprot.org/uniprot/D3E369 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/634498:MRU_RS09110 ^@ http://purl.uniprot.org/uniprot/D3DZJ1 ^@ Function|||Similarity ^@ Belongs to the Thz kinase family.|||Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). http://togogenome.org/gene/634498:MRU_RS09625 ^@ http://purl.uniprot.org/uniprot/D3E049 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrE family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/634498:MRU_RS06620 ^@ http://purl.uniprot.org/uniprot/D3E3R3 ^@ Function|||Similarity ^@ Belongs to the P(II) protein family.|||Could be involved in the regulation of nitrogen fixation. http://togogenome.org/gene/634498:MRU_RS03560 ^@ http://purl.uniprot.org/uniprot/D3E1Z2 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/634498:MRU_RS01990 ^@ http://purl.uniprot.org/uniprot/D3E0J6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/634498:MRU_RS02255 ^@ http://purl.uniprot.org/uniprot/D3E0P9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/634498:MRU_RS04120 ^@ http://purl.uniprot.org/uniprot/D3E2A7 ^@ Function|||Similarity ^@ Belongs to the HdrB family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). http://togogenome.org/gene/634498:MRU_RS06370 ^@ http://purl.uniprot.org/uniprot/D3E3L2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS02465 ^@ http://purl.uniprot.org/uniprot/D3E153 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/634498:MRU_RS05920 ^@ http://purl.uniprot.org/uniprot/D3E3C1 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm2 family.|||This subunit may be involved in monitoring complementarity of crRNA and target RNA. http://togogenome.org/gene/634498:MRU_RS08880 ^@ http://purl.uniprot.org/uniprot/D3DZE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/634498:MRU_RS09475 ^@ http://purl.uniprot.org/uniprot/D3DZR5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/634498:MRU_RS10125 ^@ http://purl.uniprot.org/uniprot/D3E0E8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FTR family.|||Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/634498:MRU_RS06105 ^@ http://purl.uniprot.org/uniprot/D3E3F9 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/634498:MRU_RS03665 ^@ http://purl.uniprot.org/uniprot/D3E212 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS09495 ^@ http://purl.uniprot.org/uniprot/D3DZR9 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/634498:MRU_RS04395 ^@ http://purl.uniprot.org/uniprot/D3E2G1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/634498:MRU_RS04465 ^@ http://purl.uniprot.org/uniprot/D3E2H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiM family.|||Cell membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Membrane|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/634498:MRU_RS09805 ^@ http://purl.uniprot.org/uniprot/D3E085 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/634498:MRU_RS05470 ^@ http://purl.uniprot.org/uniprot/D3E327 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/634498:MRU_RS00620 ^@ http://purl.uniprot.org/uniprot/D3DYQ4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS04410 ^@ http://purl.uniprot.org/uniprot/D3E2G4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS09930 ^@ http://purl.uniprot.org/uniprot/D3E0A9 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/634498:MRU_RS02210 ^@ http://purl.uniprot.org/uniprot/D3E0P0 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/634498:MRU_RS06550 ^@ http://purl.uniprot.org/uniprot/D3E3P9 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/634498:MRU_RS06600 ^@ http://purl.uniprot.org/uniprot/D3E3Q9 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/634498:MRU_RS07560 ^@ http://purl.uniprot.org/uniprot/D3E4A1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. http://togogenome.org/gene/634498:MRU_RS07070 ^@ http://purl.uniprot.org/uniprot/D3E404 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/634498:MRU_RS09070 ^@ http://purl.uniprot.org/uniprot/D3DZI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/634498:MRU_RS06780 ^@ http://purl.uniprot.org/uniprot/D3E3U4 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/634498:MRU_RS09245 ^@ http://purl.uniprot.org/uniprot/D3DZL9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/634498:MRU_RS10275 ^@ http://purl.uniprot.org/uniprot/D3E0S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/634498:MRU_RS02460 ^@ http://purl.uniprot.org/uniprot/D3E152 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/634498:MRU_RS05015 ^@ http://purl.uniprot.org/uniprot/D3E2T6 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/634498:MRU_RS00550 ^@ http://purl.uniprot.org/uniprot/D3DYP0 ^@ Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family. http://togogenome.org/gene/634498:MRU_RS01335 ^@ http://purl.uniprot.org/uniprot/D3DZE7 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/634498:MRU_RS08190 ^@ http://purl.uniprot.org/uniprot/D3E4U4 ^@ Caution|||Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS04300 ^@ http://purl.uniprot.org/uniprot/D3E2E2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS03000 ^@ http://purl.uniprot.org/uniprot/D3E1M6 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/634498:MRU_RS04610 ^@ http://purl.uniprot.org/uniprot/D3E2K4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/634498:MRU_RS08615 ^@ http://purl.uniprot.org/uniprot/D3DZ22 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Involved in protein export.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecF. http://togogenome.org/gene/634498:MRU_RS06875 ^@ http://purl.uniprot.org/uniprot/D3E3W4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS01295 ^@ http://purl.uniprot.org/uniprot/D3DZD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS10850 ^@ http://purl.uniprot.org/uniprot/D3E1C4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/634498:MRU_RS02675 ^@ http://purl.uniprot.org/uniprot/D3E195 ^@ Cofactor|||Similarity ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/634498:MRU_RS04020 ^@ http://purl.uniprot.org/uniprot/D3E286 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/634498:MRU_RS04240 ^@ http://purl.uniprot.org/uniprot/D3E2C9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/634498:MRU_RS06225 ^@ http://purl.uniprot.org/uniprot/D3E3I3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS10810 ^@ http://purl.uniprot.org/uniprot/D3E1B6 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/634498:MRU_RS02120 ^@ http://purl.uniprot.org/uniprot/D3E0M2 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS04140 ^@ http://purl.uniprot.org/uniprot/D3E2B1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS11010 ^@ http://purl.uniprot.org/uniprot/D3E1F7 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/634498:MRU_RS04325 ^@ http://purl.uniprot.org/uniprot/D3E2E7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS05595 ^@ http://purl.uniprot.org/uniprot/D3E354 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/634498:MRU_RS04565 ^@ http://purl.uniprot.org/uniprot/D3E2J5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/634498:MRU_RS02895 ^@ http://purl.uniprot.org/uniprot/D3E1K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mer family.|||Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS05885 ^@ http://purl.uniprot.org/uniprot/D3E3B3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/634498:MRU_RS02005 ^@ http://purl.uniprot.org/uniprot/D3E0J9 ^@ Caution|||Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS10240 ^@ http://purl.uniprot.org/uniprot/D3E0R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/634498:MRU_RS02170 ^@ http://purl.uniprot.org/uniprot/D3E0N2 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Homohexamer. Dimer of a homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Purine nucleoside phosphorylase involved in purine salvage. http://togogenome.org/gene/634498:MRU_RS03670 ^@ http://purl.uniprot.org/uniprot/D3E213 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS04595 ^@ http://purl.uniprot.org/uniprot/D3E2K1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/634498:MRU_RS00575 ^@ http://purl.uniprot.org/uniprot/D3DYP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS02035 ^@ http://purl.uniprot.org/uniprot/D3E0K5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/634498:MRU_RS05000 ^@ http://purl.uniprot.org/uniprot/D3E2T3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS03430 ^@ http://purl.uniprot.org/uniprot/D3E1W5 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the L-aspartate dehydrogenase family.|||Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.|||The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. http://togogenome.org/gene/634498:MRU_RS02985 ^@ http://purl.uniprot.org/uniprot/D3E1M3 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.|||Has ATPase and non-specific DNA-binding activities. http://togogenome.org/gene/634498:MRU_RS07740 ^@ http://purl.uniprot.org/uniprot/D3E4D9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS03155 ^@ http://purl.uniprot.org/uniprot/D3E1Q7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/634498:MRU_RS02260 ^@ http://purl.uniprot.org/uniprot/D3E0Q0 ^@ Caution|||Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS03310 ^@ http://purl.uniprot.org/uniprot/D3E1U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS10770 ^@ http://purl.uniprot.org/uniprot/D3E118 ^@ Function|||Similarity ^@ Belongs to the MTD family.|||Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. http://togogenome.org/gene/634498:MRU_RS10015 ^@ http://purl.uniprot.org/uniprot/D3E0C6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS08750 ^@ http://purl.uniprot.org/uniprot/D3DZ50 ^@ Similarity ^@ Belongs to the NAPRTase family. http://togogenome.org/gene/634498:MRU_RS04815 ^@ http://purl.uniprot.org/uniprot/D3E2P5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm|||Homooctamer. http://togogenome.org/gene/634498:MRU_RS00585 ^@ http://purl.uniprot.org/uniprot/D3DYP7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/634498:MRU_RS09955 ^@ http://purl.uniprot.org/uniprot/D3E0B4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/634498:MRU_RS06765 ^@ http://purl.uniprot.org/uniprot/D3E3U1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/634498:MRU_RS07395 ^@ http://purl.uniprot.org/uniprot/D3E468 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/634498:MRU_RS08660 ^@ http://purl.uniprot.org/uniprot/D3DZ31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS09280 ^@ http://purl.uniprot.org/uniprot/D3DZM6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/634498:MRU_RS10440 ^@ http://purl.uniprot.org/uniprot/D3E0V3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS06660 ^@ http://purl.uniprot.org/uniprot/D3E3S1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS08720 ^@ http://purl.uniprot.org/uniprot/D3DZ44 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS10715 ^@ http://purl.uniprot.org/uniprot/D3E106 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS00345 ^@ http://purl.uniprot.org/uniprot/D3E4M3 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/634498:MRU_RS06555 ^@ http://purl.uniprot.org/uniprot/D3E3Q0 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/634498:MRU_RS07795 ^@ http://purl.uniprot.org/uniprot/D3E4F0 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/634498:MRU_RS06245 ^@ http://purl.uniprot.org/uniprot/D3E3I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS00540 ^@ http://purl.uniprot.org/uniprot/D3DYN8 ^@ Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homotetramer; probably dimer of dimers. http://togogenome.org/gene/634498:MRU_RS07960 ^@ http://purl.uniprot.org/uniprot/D3E4P5 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/634498:MRU_RS07780 ^@ http://purl.uniprot.org/uniprot/D3E4E7 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/634498:MRU_RS09205 ^@ http://purl.uniprot.org/uniprot/D3DZL1 ^@ Function|||Similarity ^@ Belongs to the archaeal IMP cyclohydrolase family.|||Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP. http://togogenome.org/gene/634498:MRU_RS09075 ^@ http://purl.uniprot.org/uniprot/D3DZI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.|||Part of the RNA polymerase complex. http://togogenome.org/gene/634498:MRU_RS09685 ^@ http://purl.uniprot.org/uniprot/D3E061 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/634498:MRU_RS00920 ^@ http://purl.uniprot.org/uniprot/D3DZ80 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/634498:MRU_RS01095 ^@ http://purl.uniprot.org/uniprot/D3DZB5 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. http://togogenome.org/gene/634498:MRU_RS09775 ^@ http://purl.uniprot.org/uniprot/D3E079 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS03100 ^@ http://purl.uniprot.org/uniprot/D3E1P6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class U subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. http://togogenome.org/gene/634498:MRU_RS09290 ^@ http://purl.uniprot.org/uniprot/D3DZM8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/634498:MRU_RS06500 ^@ http://purl.uniprot.org/uniprot/D3E3N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS07055 ^@ http://purl.uniprot.org/uniprot/D3E401 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EhaA family.|||Cell membrane|||Membrane|||One of the integral membrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase eha. Eha is predicted to form large electron transfer complex and might catalyze energy-driven reduction of low-potential redox carriers.|||Putative multisubunit membrane-bound [NiFe]-hydrogenase eha is composed of at least 20 subunits. http://togogenome.org/gene/634498:MRU_RS01835 ^@ http://purl.uniprot.org/uniprot/D3E0G4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS07670 ^@ http://purl.uniprot.org/uniprot/D3E4C5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/634498:MRU_RS08715 ^@ http://purl.uniprot.org/uniprot/D3DZ43 ^@ Similarity ^@ Belongs to the PdaD family. http://togogenome.org/gene/634498:MRU_RS04825 ^@ http://purl.uniprot.org/uniprot/D3E2P7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS04650 ^@ http://purl.uniprot.org/uniprot/D3E2L2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS10710 ^@ http://purl.uniprot.org/uniprot/D3E105 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS09470 ^@ http://purl.uniprot.org/uniprot/D3DZR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/634498:MRU_RS06690 ^@ http://purl.uniprot.org/uniprot/D3E3S6 ^@ Similarity ^@ Belongs to the HisA/HisF family. http://togogenome.org/gene/634498:MRU_RS06250 ^@ http://purl.uniprot.org/uniprot/D3E3I8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/634498:MRU_RS00500 ^@ http://purl.uniprot.org/uniprot/D3DYN0 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/634498:MRU_RS04030 ^@ http://purl.uniprot.org/uniprot/D3E288 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/634498:MRU_RS03555 ^@ http://purl.uniprot.org/uniprot/D3E1Z1 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/634498:MRU_RS03595 ^@ http://purl.uniprot.org/uniprot/D3E1Z8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CobB/CobQ family. GatD subfamily.|||Forms a heterodimer with MurT.|||The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. http://togogenome.org/gene/634498:MRU_RS00365 ^@ http://purl.uniprot.org/uniprot/D3DYK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS12210 ^@ http://purl.uniprot.org/uniprot/D3E0S8 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS12060 ^@ http://purl.uniprot.org/uniprot/D3E2R8 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS00595 ^@ http://purl.uniprot.org/uniprot/D3DYP9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HdrA family.|||Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).|||The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC. http://togogenome.org/gene/634498:MRU_RS00440 ^@ http://purl.uniprot.org/uniprot/D3DYL7 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS03025 ^@ http://purl.uniprot.org/uniprot/D3E1N1 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/634498:MRU_RS09025 ^@ http://purl.uniprot.org/uniprot/D3DZH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS03550 ^@ http://purl.uniprot.org/uniprot/D3E1Z0 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/634498:MRU_RS04500 ^@ http://purl.uniprot.org/uniprot/D3E2I2 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.|||Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. http://togogenome.org/gene/634498:MRU_RS01475 ^@ http://purl.uniprot.org/uniprot/D3DZV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/634498:MRU_RS09630 ^@ http://purl.uniprot.org/uniprot/D3E050 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase alpha subunit family.|||Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.|||Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/634498:MRU_RS10555 ^@ http://purl.uniprot.org/uniprot/D3E0X6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. BUD32 family.|||Binds 1 Fe(2+) ion per subunit.|||Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Cytoplasm|||In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.|||In the N-terminal section; belongs to the KAE1 / TsaD family.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. http://togogenome.org/gene/634498:MRU_RS08250 ^@ http://purl.uniprot.org/uniprot/D3E4V5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/634498:MRU_RS08140 ^@ http://purl.uniprot.org/uniprot/D3E4T4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS01970 ^@ http://purl.uniprot.org/uniprot/D3E0J3 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. http://togogenome.org/gene/634498:MRU_RS04810 ^@ http://purl.uniprot.org/uniprot/D3E2P4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/634498:MRU_RS05445 ^@ http://purl.uniprot.org/uniprot/D3E322 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/634498:MRU_RS05295 ^@ http://purl.uniprot.org/uniprot/D3E2Z3 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/634498:MRU_RS04790 ^@ http://purl.uniprot.org/uniprot/D3E2P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/634498:MRU_RS04730 ^@ http://purl.uniprot.org/uniprot/D3E2M8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS05915 ^@ http://purl.uniprot.org/uniprot/D3E3C0 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm3 family. http://togogenome.org/gene/634498:MRU_RS09165 ^@ http://purl.uniprot.org/uniprot/D3DZK3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer. http://togogenome.org/gene/634498:MRU_RS02475 ^@ http://purl.uniprot.org/uniprot/D3E155 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/634498:MRU_RS08995 ^@ http://purl.uniprot.org/uniprot/D3DZH3 ^@ Similarity ^@ Belongs to the UPF0146 family. http://togogenome.org/gene/634498:MRU_RS02400 ^@ http://purl.uniprot.org/uniprot/D3E141 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/634498:MRU_RS09900 ^@ http://purl.uniprot.org/uniprot/D3E0A3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/634498:MRU_RS09255 ^@ http://purl.uniprot.org/uniprot/D3DZM1 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/634498:MRU_RS07445 ^@ http://purl.uniprot.org/uniprot/D3E478 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/634498:MRU_RS03450 ^@ http://purl.uniprot.org/uniprot/D3E1W9 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/634498:MRU_RS03590 ^@ http://purl.uniprot.org/uniprot/D3E1Z7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MurCDEF family. MurT subfamily.|||Forms a heterodimer with GatD.|||The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. http://togogenome.org/gene/634498:MRU_RS11155 ^@ http://purl.uniprot.org/uniprot/D3E4J5 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/634498:MRU_RS04620 ^@ http://purl.uniprot.org/uniprot/D3E2K6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/634498:MRU_RS06335 ^@ http://purl.uniprot.org/uniprot/D3E3K5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. CofH family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.|||The FO synthase complex consists of two subunits, CofG and CofH. http://togogenome.org/gene/634498:MRU_RS04425 ^@ http://purl.uniprot.org/uniprot/D3E2G7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS08170 ^@ http://purl.uniprot.org/uniprot/D3E4U0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS08345 ^@ http://purl.uniprot.org/uniprot/D3DYW9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS06795 ^@ http://purl.uniprot.org/uniprot/D3E3U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/634498:MRU_RS10110 ^@ http://purl.uniprot.org/uniprot/D3E0E5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS04430 ^@ http://purl.uniprot.org/uniprot/D3E2G8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/634498:MRU_RS06415 ^@ http://purl.uniprot.org/uniprot/D3E3M2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the creatininase superfamily. FAPy deformylase family.|||Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).|||Homodimer.|||Requires an additional second metal ion that could be Fe(2+) or Zn(2+).|||Requires one Fe(2+) ion for activity. http://togogenome.org/gene/634498:MRU_RS06585 ^@ http://purl.uniprot.org/uniprot/D3E3Q6 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/634498:MRU_RS02315 ^@ http://purl.uniprot.org/uniprot/D3E124 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/634498:MRU_RS03295 ^@ http://purl.uniprot.org/uniprot/D3E1T8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. http://togogenome.org/gene/634498:MRU_RS06050 ^@ http://purl.uniprot.org/uniprot/D3E3E8 ^@ Function|||Similarity ^@ Belongs to the MfnB family.|||Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). http://togogenome.org/gene/634498:MRU_RS07775 ^@ http://purl.uniprot.org/uniprot/D3E4E6 ^@ Cofactor|||Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/634498:MRU_RS09410 ^@ http://purl.uniprot.org/uniprot/D3DZQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS09650 ^@ http://purl.uniprot.org/uniprot/D3E054 ^@ Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase beta subunit family.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/634498:MRU_RS02225 ^@ http://purl.uniprot.org/uniprot/D3E0P3 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/634498:MRU_RS07405 ^@ http://purl.uniprot.org/uniprot/D3E470 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/634498:MRU_RS07760 ^@ http://purl.uniprot.org/uniprot/D3E4E3 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro. http://togogenome.org/gene/634498:MRU_RS03110 ^@ http://purl.uniprot.org/uniprot/D3E1P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS05535 ^@ http://purl.uniprot.org/uniprot/D3E342 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/634498:MRU_RS04600 ^@ http://purl.uniprot.org/uniprot/D3E2K2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/634498:MRU_RS09485 ^@ http://purl.uniprot.org/uniprot/D3DZR7 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/634498:MRU_RS01065 ^@ http://purl.uniprot.org/uniprot/D3DZA9 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/634498:MRU_RS06390 ^@ http://purl.uniprot.org/uniprot/D3E3L6 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/634498:MRU_RS06030 ^@ http://purl.uniprot.org/uniprot/D3E3E4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/634498:MRU_RS02140 ^@ http://purl.uniprot.org/uniprot/D3E0M6 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/634498:MRU_RS10195 ^@ http://purl.uniprot.org/uniprot/D3E0F5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/634498:MRU_RS09335 ^@ http://purl.uniprot.org/uniprot/D3DZN7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/634498:MRU_RS02040 ^@ http://purl.uniprot.org/uniprot/D3E0K6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/634498:MRU_RS06770 ^@ http://purl.uniprot.org/uniprot/D3E3U2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS09600 ^@ http://purl.uniprot.org/uniprot/D3E044 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrF family.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/634498:MRU_RS00895 ^@ http://purl.uniprot.org/uniprot/D3DYW0 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/634498:MRU_RS09460 ^@ http://purl.uniprot.org/uniprot/D3DZR2 ^@ Similarity ^@ Belongs to the LarC family. http://togogenome.org/gene/634498:MRU_RS03065 ^@ http://purl.uniprot.org/uniprot/D3E1N9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS10610 ^@ http://purl.uniprot.org/uniprot/D3E0Y6 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS11110 ^@ http://purl.uniprot.org/uniprot/D3E1H8 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/634498:MRU_RS08165 ^@ http://purl.uniprot.org/uniprot/D3E4T9 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/634498:MRU_RS04000 ^@ http://purl.uniprot.org/uniprot/D3E282 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/634498:MRU_RS00755 ^@ http://purl.uniprot.org/uniprot/D3DYT1 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/634498:MRU_RS07220 ^@ http://purl.uniprot.org/uniprot/D3E434 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/634498:MRU_RS01700 ^@ http://purl.uniprot.org/uniprot/D3E007 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS00140 ^@ http://purl.uniprot.org/uniprot/D3E4I3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/634498:MRU_RS01275 ^@ http://purl.uniprot.org/uniprot/D3DZD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/634498:MRU_RS04315 ^@ http://purl.uniprot.org/uniprot/D3E2E5 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/634498:MRU_RS08840 ^@ http://purl.uniprot.org/uniprot/D3DZ68 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/634498:MRU_RS08630 ^@ http://purl.uniprot.org/uniprot/D3DZ25 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/634498:MRU_RS09125 ^@ http://purl.uniprot.org/uniprot/D3DZJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/634498:MRU_RS08780 ^@ http://purl.uniprot.org/uniprot/D3DZ56 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/634498:MRU_RS03540 ^@ http://purl.uniprot.org/uniprot/D3E1Y8 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/634498:MRU_RS06425 ^@ http://purl.uniprot.org/uniprot/D3E3M4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS10435 ^@ http://purl.uniprot.org/uniprot/D3E0V2 ^@ Similarity ^@ Belongs to the MvhD/VhuD family. http://togogenome.org/gene/634498:MRU_RS00915 ^@ http://purl.uniprot.org/uniprot/D3DZ79 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/634498:MRU_RS06615 ^@ http://purl.uniprot.org/uniprot/D3E3R2 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/634498:MRU_RS10135 ^@ http://purl.uniprot.org/uniprot/D3E0F0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS07330 ^@ http://purl.uniprot.org/uniprot/D3E455 ^@ Similarity ^@ Belongs to the NifH/BchL/ChlL family. http://togogenome.org/gene/634498:MRU_RS08945 ^@ http://purl.uniprot.org/uniprot/D3DZG3 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS09490 ^@ http://purl.uniprot.org/uniprot/D3DZR8 ^@ Function|||Similarity ^@ Belongs to the group II decarboxylase family. MfnA subfamily.|||Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. http://togogenome.org/gene/634498:MRU_RS07890 ^@ http://purl.uniprot.org/uniprot/D3E4N1 ^@ Function ^@ Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/634498:MRU_RS00050 ^@ http://purl.uniprot.org/uniprot/D3E4G6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/634498:MRU_RS07455 ^@ http://purl.uniprot.org/uniprot/D3E480 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal histone HMF family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS09180 ^@ http://purl.uniprot.org/uniprot/D3DZK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/634498:MRU_RS00015 ^@ http://purl.uniprot.org/uniprot/D3E4F9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS04635 ^@ http://purl.uniprot.org/uniprot/D3E2K9 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/634498:MRU_RS04640 ^@ http://purl.uniprot.org/uniprot/D3E2L0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/634498:MRU_RS06850 ^@ http://purl.uniprot.org/uniprot/D3E3V9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS03445 ^@ http://purl.uniprot.org/uniprot/D3E1W8 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/634498:MRU_RS07810 ^@ http://purl.uniprot.org/uniprot/D3E4F3 ^@ Cofactor|||Similarity ^@ Belongs to the desulfoferrodoxin family.|||Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.|||Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues. http://togogenome.org/gene/634498:MRU_RS06965 ^@ http://purl.uniprot.org/uniprot/D3E3Y2 ^@ Similarity ^@ Belongs to the FTR family. http://togogenome.org/gene/634498:MRU_RS07470 ^@ http://purl.uniprot.org/uniprot/D3E483 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS09350 ^@ http://purl.uniprot.org/uniprot/D3DZP0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/634498:MRU_RS11270 ^@ http://purl.uniprot.org/uniprot/D3E1E7 ^@ Similarity ^@ Belongs to the CDP-glycerol glycerophosphotransferase family. http://togogenome.org/gene/634498:MRU_RS03145 ^@ http://purl.uniprot.org/uniprot/D3E1Q5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS05055 ^@ http://purl.uniprot.org/uniprot/D3E2U4 ^@ Similarity ^@ Belongs to the MtxX family. http://togogenome.org/gene/634498:MRU_RS03535 ^@ http://purl.uniprot.org/uniprot/D3E1Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane http://togogenome.org/gene/634498:MRU_RS09275 ^@ http://purl.uniprot.org/uniprot/D3DZM5 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/634498:MRU_RS08455 ^@ http://purl.uniprot.org/uniprot/D3DYY9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Heterotetramer of 2 HacA and 2 HacB proteins.|||Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B. http://togogenome.org/gene/634498:MRU_RS01995 ^@ http://purl.uniprot.org/uniprot/D3E0J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/634498:MRU_RS04330 ^@ http://purl.uniprot.org/uniprot/D3E2E8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/634498:MRU_RS06125 ^@ http://purl.uniprot.org/uniprot/D3E3G3 ^@ Similarity ^@ Belongs to the UPF0200 family. http://togogenome.org/gene/634498:MRU_RS06760 ^@ http://purl.uniprot.org/uniprot/D3E3U0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS03500 ^@ http://purl.uniprot.org/uniprot/D3E1Y0 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/634498:MRU_RS03010 ^@ http://purl.uniprot.org/uniprot/D3E1M8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/634498:MRU_RS11235 ^@ http://purl.uniprot.org/uniprot/D3DZN2 ^@ Similarity ^@ Belongs to the CbxX/CfxQ family. http://togogenome.org/gene/634498:MRU_RS00795 ^@ http://purl.uniprot.org/uniprot/D3DYU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/634498:MRU_RS08640 ^@ http://purl.uniprot.org/uniprot/D3DZ27 ^@ Similarity ^@ Belongs to the peptidase U62 family. http://togogenome.org/gene/634498:MRU_RS02775 ^@ http://purl.uniprot.org/uniprot/D3E1I6 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/634498:MRU_RS05105 ^@ http://purl.uniprot.org/uniprot/D3E2V5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/634498:MRU_RS10550 ^@ http://purl.uniprot.org/uniprot/D3E0X5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/634498:MRU_RS04480 ^@ http://purl.uniprot.org/uniprot/D3E2H8 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/634498:MRU_RS08905 ^@ http://purl.uniprot.org/uniprot/D3DZF4 ^@ Similarity ^@ Belongs to the MoaB/Mog family. http://togogenome.org/gene/634498:MRU_RS01960 ^@ http://purl.uniprot.org/uniprot/D3E0J1 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/634498:MRU_RS00690 ^@ http://purl.uniprot.org/uniprot/D3DYR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/634498:MRU_RS08520 ^@ http://purl.uniprot.org/uniprot/D3DZ02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS07900 ^@ http://purl.uniprot.org/uniprot/D3E4N3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/634498:MRU_RS01730 ^@ http://purl.uniprot.org/uniprot/D3E013 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS07615 ^@ http://purl.uniprot.org/uniprot/D3E4B3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS09500 ^@ http://purl.uniprot.org/uniprot/D3DZS0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/634498:MRU_RS09380 ^@ http://purl.uniprot.org/uniprot/D3DZP6 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/634498:MRU_RS06015 ^@ http://purl.uniprot.org/uniprot/D3E3E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS01945 ^@ http://purl.uniprot.org/uniprot/D3E0I8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/634498:MRU_RS06475 ^@ http://purl.uniprot.org/uniprot/D3E3N4 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/634498:MRU_RS02305 ^@ http://purl.uniprot.org/uniprot/D3E0Q9 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. http://togogenome.org/gene/634498:MRU_RS07460 ^@ http://purl.uniprot.org/uniprot/D3E481 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/634498:MRU_RS04390 ^@ http://purl.uniprot.org/uniprot/D3E2G0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS04770 ^@ http://purl.uniprot.org/uniprot/D3E2N6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/634498:MRU_RS08655 ^@ http://purl.uniprot.org/uniprot/D3DZ30 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/634498:MRU_RS04420 ^@ http://purl.uniprot.org/uniprot/D3E2G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS08525 ^@ http://purl.uniprot.org/uniprot/D3DZ03 ^@ Caution|||Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS06750 ^@ http://purl.uniprot.org/uniprot/D3E3T8 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/634498:MRU_RS02445 ^@ http://purl.uniprot.org/uniprot/D3E149 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/634498:MRU_RS07425 ^@ http://purl.uniprot.org/uniprot/D3E474 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/634498:MRU_RS02565 ^@ http://purl.uniprot.org/uniprot/D3E173 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family. RadB subfamily.|||Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. http://togogenome.org/gene/634498:MRU_RS10640 ^@ http://purl.uniprot.org/uniprot/D3E0Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS00535 ^@ http://purl.uniprot.org/uniprot/D3DYN7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/634498:MRU_RS10615 ^@ http://purl.uniprot.org/uniprot/D3E0Y7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/634498:MRU_RS09910 ^@ http://purl.uniprot.org/uniprot/D3E0A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS07835 ^@ http://purl.uniprot.org/uniprot/D3E4M5 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/634498:MRU_RS02045 ^@ http://purl.uniprot.org/uniprot/D3E0K7 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/634498:MRU_RS06860 ^@ http://purl.uniprot.org/uniprot/D3E3W1 ^@ Similarity ^@ Belongs to the UPRTase family. http://togogenome.org/gene/634498:MRU_RS09705 ^@ http://purl.uniprot.org/uniprot/D3E065 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/634498:MRU_RS05905 ^@ http://purl.uniprot.org/uniprot/D3E3B8 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm5 family.|||This subunit might be involved in maturation of a crRNA intermediate to its mature form. http://togogenome.org/gene/634498:MRU_RS07125 ^@ http://purl.uniprot.org/uniprot/D3E416 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/634498:MRU_RS07720 ^@ http://purl.uniprot.org/uniprot/D3E4D5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/634498:MRU_RS07745 ^@ http://purl.uniprot.org/uniprot/D3E4E0 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/634498:MRU_RS07695 ^@ http://purl.uniprot.org/uniprot/D3E4D0 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/634498:MRU_RS08090 ^@ http://purl.uniprot.org/uniprot/D3E4S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/634498:MRU_RS10345 ^@ http://purl.uniprot.org/uniprot/D3E0T4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/634498:MRU_RS07945 ^@ http://purl.uniprot.org/uniprot/D3E4P2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/634498:MRU_RS06120 ^@ http://purl.uniprot.org/uniprot/D3E3G2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/634498:MRU_RS04475 ^@ http://purl.uniprot.org/uniprot/D3E2H7 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/634498:MRU_RS09190 ^@ http://purl.uniprot.org/uniprot/D3DZK8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS05230 ^@ http://purl.uniprot.org/uniprot/D3E2Y0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the small carbamoyl-phosphate synthase family.|||Binds 2 magnesium or manganese ions per subunit.|||Catalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate. http://togogenome.org/gene/634498:MRU_RS05415 ^@ http://purl.uniprot.org/uniprot/D3E316 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS06130 ^@ http://purl.uniprot.org/uniprot/D3E3G4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS08590 ^@ http://purl.uniprot.org/uniprot/D3DZ17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS04470 ^@ http://purl.uniprot.org/uniprot/D3E2H6 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/634498:MRU_RS07630 ^@ http://purl.uniprot.org/uniprot/D3E4B6 ^@ Similarity ^@ Belongs to the glycosyltransferase 10 family. http://togogenome.org/gene/634498:MRU_RS00995 ^@ http://purl.uniprot.org/uniprot/D3DZ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/634498:MRU_RS02370 ^@ http://purl.uniprot.org/uniprot/D3E135 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS09010 ^@ http://purl.uniprot.org/uniprot/D3DZH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS04455 ^@ http://purl.uniprot.org/uniprot/D3E2H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS05545 ^@ http://purl.uniprot.org/uniprot/D3E344 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/634498:MRU_RS04345 ^@ http://purl.uniprot.org/uniprot/D3E2F1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS08635 ^@ http://purl.uniprot.org/uniprot/D3DZ26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intimin/invasin family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/634498:MRU_RS07685 ^@ http://purl.uniprot.org/uniprot/D3E4C8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/634498:MRU_RS09635 ^@ http://purl.uniprot.org/uniprot/D3E051 ^@ Similarity|||Subunit ^@ Belongs to the methyl-coenzyme M reductase gamma subunit family.|||Hexamer of two alpha, two beta, and two gamma chains.|||MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers. http://togogenome.org/gene/634498:MRU_RS00225 ^@ http://purl.uniprot.org/uniprot/D3E4K0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS03195 ^@ http://purl.uniprot.org/uniprot/D3E1R7 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/634498:MRU_RS07300 ^@ http://purl.uniprot.org/uniprot/D3E450 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/634498:MRU_RS03340 ^@ http://purl.uniprot.org/uniprot/D3E1U7 ^@ Function|||Subunit ^@ Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/634498:MRU_RS05175 ^@ http://purl.uniprot.org/uniprot/D3E2W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS08950 ^@ http://purl.uniprot.org/uniprot/D3DZG4 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/634498:MRU_RS00040 ^@ http://purl.uniprot.org/uniprot/D3E4G4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS02130 ^@ http://purl.uniprot.org/uniprot/D3E0M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intimin/invasin family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/634498:MRU_RS02790 ^@ http://purl.uniprot.org/uniprot/D3E1I9 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/634498:MRU_RS02135 ^@ http://purl.uniprot.org/uniprot/D3E0M5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/634498:MRU_RS00830 ^@ http://purl.uniprot.org/uniprot/D3DYU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.|||Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/634498:MRU_RS10700 ^@ http://purl.uniprot.org/uniprot/D3E103 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/634498:MRU_RS05195 ^@ http://purl.uniprot.org/uniprot/D3E2X3 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/634498:MRU_RS02050 ^@ http://purl.uniprot.org/uniprot/D3E0K8 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/634498:MRU_RS03575 ^@ http://purl.uniprot.org/uniprot/D3E1Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/634498:MRU_RS06625 ^@ http://purl.uniprot.org/uniprot/D3E3R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/634498:MRU_RS05080 ^@ http://purl.uniprot.org/uniprot/D3E2V0 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/634498:MRU_RS06355 ^@ http://purl.uniprot.org/uniprot/D3E3K9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS02065 ^@ http://purl.uniprot.org/uniprot/D3E0L1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS04905 ^@ http://purl.uniprot.org/uniprot/D3E2R4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/634498:MRU_RS04805 ^@ http://purl.uniprot.org/uniprot/D3E2P3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofC family.|||Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS03335 ^@ http://purl.uniprot.org/uniprot/D3E1U6 ^@ Cofactor ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP. http://togogenome.org/gene/634498:MRU_RS04575 ^@ http://purl.uniprot.org/uniprot/D3E2J7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS04250 ^@ http://purl.uniprot.org/uniprot/D3E2D1 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/634498:MRU_RS09215 ^@ http://purl.uniprot.org/uniprot/D3DZL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/634498:MRU_RS03690 ^@ http://purl.uniprot.org/uniprot/D3E218 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/634498:MRU_RS05345 ^@ http://purl.uniprot.org/uniprot/D3E302 ^@ Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family. http://togogenome.org/gene/634498:MRU_RS08135 ^@ http://purl.uniprot.org/uniprot/D3E4T3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS00335 ^@ http://purl.uniprot.org/uniprot/D3E4M1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/634498:MRU_RS07420 ^@ http://purl.uniprot.org/uniprot/D3E473 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/634498:MRU_RS07430 ^@ http://purl.uniprot.org/uniprot/D3E475 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/634498:MRU_RS04580 ^@ http://purl.uniprot.org/uniprot/D3E2J8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Binds 1 [3Fe-4S] cluster.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/634498:MRU_RS00525 ^@ http://purl.uniprot.org/uniprot/D3DYN5 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/634498:MRU_RS09015 ^@ http://purl.uniprot.org/uniprot/D3DZH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/634498:MRU_RS09940 ^@ http://purl.uniprot.org/uniprot/D3E0B1 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/634498:MRU_RS06705 ^@ http://purl.uniprot.org/uniprot/D3E3S9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS01320 ^@ http://purl.uniprot.org/uniprot/D3DZE4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS06985 ^@ http://purl.uniprot.org/uniprot/D3E3Y7 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/634498:MRU_RS04380 ^@ http://purl.uniprot.org/uniprot/D3E2F8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/634498:MRU_RS00835 ^@ http://purl.uniprot.org/uniprot/D3DYU8 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/634498:MRU_RS05495 ^@ http://purl.uniprot.org/uniprot/D3E332 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/634498:MRU_RS01015 ^@ http://purl.uniprot.org/uniprot/D3DZ99 ^@ Similarity ^@ Belongs to the UPF0107 family. http://togogenome.org/gene/634498:MRU_RS05420 ^@ http://purl.uniprot.org/uniprot/D3E317 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/634498:MRU_RS05925 ^@ http://purl.uniprot.org/uniprot/D3E3C2 ^@ Similarity ^@ Belongs to the CRISPR-associated Cas10/Csm1 family. http://togogenome.org/gene/634498:MRU_RS07385 ^@ http://purl.uniprot.org/uniprot/D3E466 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS00885 ^@ http://purl.uniprot.org/uniprot/D3DYV8 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/634498:MRU_RS10955 ^@ http://purl.uniprot.org/uniprot/D3E1E6 ^@ Similarity ^@ Belongs to the CDP-glycerol glycerophosphotransferase family. http://togogenome.org/gene/634498:MRU_RS02570 ^@ http://purl.uniprot.org/uniprot/D3E174 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/634498:MRU_RS09220 ^@ http://purl.uniprot.org/uniprot/D3DZL4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the CofE family.|||Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.|||Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.|||Homodimer.|||Monovalent cation. The ion could be potassium. http://togogenome.org/gene/634498:MRU_RS08020 ^@ http://purl.uniprot.org/uniprot/D3E4Q8 ^@ Similarity ^@ Belongs to the beta-class carbonic anhydrase family. http://togogenome.org/gene/634498:MRU_RS00485 ^@ http://purl.uniprot.org/uniprot/D3DYM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS00990 ^@ http://purl.uniprot.org/uniprot/D3DZ94 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/634498:MRU_RS08460 ^@ http://purl.uniprot.org/uniprot/D3DYZ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/634498:MRU_RS07355 ^@ http://purl.uniprot.org/uniprot/D3E460 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/634498:MRU_RS03240 ^@ http://purl.uniprot.org/uniprot/D3E1S6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS01935 ^@ http://purl.uniprot.org/uniprot/D3E0I6 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. http://togogenome.org/gene/634498:MRU_RS09230 ^@ http://purl.uniprot.org/uniprot/D3DZL6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CofD family.|||Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS02605 ^@ http://purl.uniprot.org/uniprot/D3E181 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/634498:MRU_RS06430 ^@ http://purl.uniprot.org/uniprot/D3E3M5 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/634498:MRU_RS05665 ^@ http://purl.uniprot.org/uniprot/D3E368 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/634498:MRU_RS10245 ^@ http://purl.uniprot.org/uniprot/D3E0R5 ^@ Function|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family. http://togogenome.org/gene/634498:MRU_RS08920 ^@ http://purl.uniprot.org/uniprot/D3DZF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/634498:MRU_RS05020 ^@ http://purl.uniprot.org/uniprot/D3E2T7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.|||Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.|||Homodecamer. http://togogenome.org/gene/634498:MRU_RS06080 ^@ http://purl.uniprot.org/uniprot/D3E3F4 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/634498:MRU_RS05305 ^@ http://purl.uniprot.org/uniprot/D3E2Z5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/634498:MRU_RS10600 ^@ http://purl.uniprot.org/uniprot/D3E0Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).|||Cell membrane|||Membrane http://togogenome.org/gene/634498:MRU_RS07340 ^@ http://purl.uniprot.org/uniprot/D3E457 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/634498:MRU_RS09895 ^@ http://purl.uniprot.org/uniprot/D3E0A2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). http://togogenome.org/gene/634498:MRU_RS06300 ^@ http://purl.uniprot.org/uniprot/D3E3J8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit.|||Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. http://togogenome.org/gene/634498:MRU_RS04305 ^@ http://purl.uniprot.org/uniprot/D3E2E3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/634498:MRU_RS06865 ^@ http://purl.uniprot.org/uniprot/D3E3W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/634498:MRU_RS04375 ^@ http://purl.uniprot.org/uniprot/D3E2F7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS01280 ^@ http://purl.uniprot.org/uniprot/D3DZD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.|||Membrane http://togogenome.org/gene/634498:MRU_RS08555 ^@ http://purl.uniprot.org/uniprot/D3DZ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/634498:MRU_RS08355 ^@ http://purl.uniprot.org/uniprot/D3DYX1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/634498:MRU_RS06785 ^@ http://purl.uniprot.org/uniprot/D3E3U6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/634498:MRU_RS07435 ^@ http://purl.uniprot.org/uniprot/D3E476 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/634498:MRU_RS09960 ^@ http://purl.uniprot.org/uniprot/D3E0B5 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS01055 ^@ http://purl.uniprot.org/uniprot/D3DZA7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS08365 ^@ http://purl.uniprot.org/uniprot/D3DYX3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/634498:MRU_RS04350 ^@ http://purl.uniprot.org/uniprot/D3E2F2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/634498:MRU_RS09435 ^@ http://purl.uniprot.org/uniprot/D3DZQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/634498:MRU_RS03650 ^@ http://purl.uniprot.org/uniprot/D3E209 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/634498:MRU_RS06410 ^@ http://purl.uniprot.org/uniprot/D3E3M1 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/634498:MRU_RS08105 ^@ http://purl.uniprot.org/uniprot/D3E4S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCH family.|||Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS08685 ^@ http://purl.uniprot.org/uniprot/D3DZ36 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/634498:MRU_RS01315 ^@ http://purl.uniprot.org/uniprot/D3DZE3 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/634498:MRU_RS08705 ^@ http://purl.uniprot.org/uniprot/D3DZ41 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/634498:MRU_RS04295 ^@ http://purl.uniprot.org/uniprot/D3E2E1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/634498:MRU_RS00700 ^@ http://purl.uniprot.org/uniprot/D3DYR9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/634498:MRU_RS05340 ^@ http://purl.uniprot.org/uniprot/D3E301 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/634498:MRU_RS03545 ^@ http://purl.uniprot.org/uniprot/D3E1Y9 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/634498:MRU_RS07010 ^@ http://purl.uniprot.org/uniprot/D3E3Z2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS09030 ^@ http://purl.uniprot.org/uniprot/D3DZI0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/634498:MRU_RS00490 ^@ http://purl.uniprot.org/uniprot/D3DYM8 ^@ Function ^@ Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/634498:MRU_RS08060 ^@ http://purl.uniprot.org/uniprot/D3E4R6 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/634498:MRU_RS09810 ^@ http://purl.uniprot.org/uniprot/D3E086 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/634498:MRU_RS04435 ^@ http://purl.uniprot.org/uniprot/D3E2G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/634498:MRU_RS02635 ^@ http://purl.uniprot.org/uniprot/D3E188 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/634498:MRU_RS00880 ^@ http://purl.uniprot.org/uniprot/D3DYV7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS02730 ^@ http://purl.uniprot.org/uniprot/D3E1A7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS11030 ^@ http://purl.uniprot.org/uniprot/D3E1G2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS04260 ^@ http://purl.uniprot.org/uniprot/D3E2D3 ^@ Similarity ^@ Belongs to the intimin/invasin family.|||Belongs to the peptidase C1 family. http://togogenome.org/gene/634498:MRU_RS04860 ^@ http://purl.uniprot.org/uniprot/D3E2Q4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS06755 ^@ http://purl.uniprot.org/uniprot/D3E3T9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/634498:MRU_RS09200 ^@ http://purl.uniprot.org/uniprot/D3DZL0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/634498:MRU_RS04210 ^@ http://purl.uniprot.org/uniprot/D3E2C4 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/634498:MRU_RS09605 ^@ http://purl.uniprot.org/uniprot/D3E045 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MtrA family.|||Binds 1 5-hydroxybenzimidazolylcobamide group.|||Cell membrane|||Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.|||The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. http://togogenome.org/gene/634498:MRU_RS05555 ^@ http://purl.uniprot.org/uniprot/D3E346 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/634498:MRU_RS00940 ^@ http://purl.uniprot.org/uniprot/D3DZ84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/634498:MRU_RS06280 ^@ http://purl.uniprot.org/uniprot/D3E3J4 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/634498:MRU_RS00530 ^@ http://purl.uniprot.org/uniprot/D3DYN6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/634498:MRU_RS03530 ^@ http://purl.uniprot.org/uniprot/D3E1Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/634498:MRU_RS06840 ^@ http://purl.uniprot.org/uniprot/D3E3V7 ^@ Similarity ^@ Belongs to the peptidase C59 family. http://togogenome.org/gene/634498:MRU_RS07895 ^@ http://purl.uniprot.org/uniprot/D3E4N2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/634498:MRU_RS08200 ^@ http://purl.uniprot.org/uniprot/D3E4U6 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/634498:MRU_RS04085 ^@ http://purl.uniprot.org/uniprot/D3E2A0 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/634498:MRU_RS06295 ^@ http://purl.uniprot.org/uniprot/D3E3J7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit.|||Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. http://togogenome.org/gene/634498:MRU_RS04585 ^@ http://purl.uniprot.org/uniprot/D3E2J9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/634498:MRU_RS04405 ^@ http://purl.uniprot.org/uniprot/D3E2G3 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/634498:MRU_RS09120 ^@ http://purl.uniprot.org/uniprot/D3DZJ3 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/634498:MRU_RS01345 ^@ http://purl.uniprot.org/uniprot/D3DZS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/634498:MRU_RS05285 ^@ http://purl.uniprot.org/uniprot/D3E2Z1 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/634498:MRU_RS10465 ^@ http://purl.uniprot.org/uniprot/D3E0V8 ^@ Similarity ^@ Belongs to the glutamate synthase family.