http://togogenome.org/gene/70601:PH_RS00680 ^@ http://purl.uniprot.org/uniprot/O57882 ^@ Function|||Similarity ^@ Belongs to the 2-phosphoglycerate kinase family.|||Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. http://togogenome.org/gene/70601:PH_RS03215 ^@ http://purl.uniprot.org/uniprot/O58419 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/70601:PH_RS05020 ^@ http://purl.uniprot.org/uniprot/O58796 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/70601:PH_RS01055 ^@ http://purl.uniprot.org/uniprot/O57971 ^@ PTM|||Similarity|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity (By similarity).|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer (By similarity). http://togogenome.org/gene/70601:PH_RS08705 ^@ http://purl.uniprot.org/uniprot/O59511 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/70601:PH_RS08050 ^@ http://purl.uniprot.org/uniprot/O59410 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/70601:PH_RS07400 ^@ http://purl.uniprot.org/uniprot/O59209 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/70601:PH_RS06395 ^@ http://purl.uniprot.org/uniprot/O59073 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/70601:PH_RS08850 ^@ http://purl.uniprot.org/uniprot/O59545 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/70601:PH_RS01300 ^@ http://purl.uniprot.org/uniprot/O58028 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS07285 ^@ http://purl.uniprot.org/uniprot/O59229 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/70601:PH_RS09410 ^@ http://purl.uniprot.org/uniprot/O57711 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/70601:PH_RS01795 ^@ http://purl.uniprot.org/uniprot/O58134 ^@ Similarity ^@ Belongs to the CDP-glycerol glycerophosphotransferase family. http://togogenome.org/gene/70601:PH_RS09420 ^@ http://purl.uniprot.org/uniprot/O57709 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. C-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/70601:PH_RS09445 ^@ http://purl.uniprot.org/uniprot/O57705 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. The stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive P1 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric uL10/P0(P1)2(P1)2(P1)2 complex, where uL10/P0 forms an elongated spine to which the P1 dimers bind in a sequential fashion. http://togogenome.org/gene/70601:PH_RS08340 ^@ http://purl.uniprot.org/uniprot/O59429 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS08390 ^@ http://purl.uniprot.org/uniprot/O74095 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/70601:PH_RS00240 ^@ http://purl.uniprot.org/uniprot/O57812 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS08975 ^@ http://purl.uniprot.org/uniprot/O74104 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/70601:PH_RS07180 ^@ http://purl.uniprot.org/uniprot/O59188 ^@ Activity Regulation|||Function|||Subunit ^@ DNA-binding protein involved in the repression of transcription of a large number of genes, thereby arresting growth, in response to environmental changes (PubMed:14976242, PubMed:18073105). Binding sites are identified in promoters of approximately 200 transcription units, including genes involved in ATP synthesis, transmembrane transport, translation and DNA synthesis (PubMed:18073105).|||Homodimer (PubMed:14976242, PubMed:18073105, PubMed:19004003). Binds DNA as a dimer and an octamer (PubMed:18073105, PubMed:19004003). The octamer formed with lysine is stable in solution, but the octamer formed with arginine is unstable without DNA (PubMed:19004003). When crystallized in the absence of DNA, dimers are assembled into helical cylinders with six dimers per turn (PubMed:14976242). In solution, predominantly behaves as a dimer (PubMed:14976242).|||In the famine mode, FL11 forms dimers and acts as a repressor, leading to growth arrest (PubMed:18073105). In the feast mode, in the presence of high concentrations of lysine or arginine, four dimers assemble into an octamer and cover the fl11 and lysine biosynthesis promoters (PubMed:18073105, PubMed:19004003). This leads to the inhibition of fl11 expression and lysine biosynthesis, decrease of the FL11 concentration in the cell, derepression of the target genes and activation of the metabolism (PubMed:18073105). http://togogenome.org/gene/70601:PH_RS00565 ^@ http://purl.uniprot.org/uniprot/O57863 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). http://togogenome.org/gene/70601:PH_RS02060 ^@ http://purl.uniprot.org/uniprot/O73972 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/70601:PH_RS08090 ^@ http://purl.uniprot.org/uniprot/O59402 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family. LysK subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS08980 ^@ http://purl.uniprot.org/uniprot/O74105 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/70601:PH_RS09015 ^@ http://purl.uniprot.org/uniprot/O59570 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/70601:PH_RS00820 ^@ http://purl.uniprot.org/uniprot/O57920 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/70601:PH_RS04400 ^@ http://purl.uniprot.org/uniprot/O58686 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/70601:PH_RS08715 ^@ http://purl.uniprot.org/uniprot/O59508 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS06465 ^@ http://purl.uniprot.org/uniprot/O59086 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/70601:PH_RS05725 ^@ http://purl.uniprot.org/uniprot/O58964 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||In the N-terminal section; belongs to the MobA family. http://togogenome.org/gene/70601:PH_RS07530 ^@ http://purl.uniprot.org/uniprot/P0CL73 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/70601:PH_RS03805 ^@ http://purl.uniprot.org/uniprot/O58539 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS02095 ^@ http://purl.uniprot.org/uniprot/O58181 ^@ Similarity ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family. http://togogenome.org/gene/70601:PH_RS06770 ^@ http://purl.uniprot.org/uniprot/O59101 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS04175 ^@ http://purl.uniprot.org/uniprot/O58614 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/70601:PH_RS01665 ^@ http://purl.uniprot.org/uniprot/O58111 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. http://togogenome.org/gene/70601:PH_RS07295 ^@ http://purl.uniprot.org/uniprot/O74018 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/70601:PH_RS08655 ^@ http://purl.uniprot.org/uniprot/O59499 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/70601:PH_RS08285 ^@ http://purl.uniprot.org/uniprot/O59441 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS07810 ^@ http://purl.uniprot.org/uniprot/O59346 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro. http://togogenome.org/gene/70601:PH_RS09285 ^@ http://purl.uniprot.org/uniprot/O59613 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS02355 ^@ http://purl.uniprot.org/uniprot/O58240 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS07510 ^@ http://purl.uniprot.org/uniprot/O59259 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/70601:PH_RS09450 ^@ http://purl.uniprot.org/uniprot/O74109 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms the large subunit's ribosomal stalk, playing a central role in the interaction of the ribosome with elongation factors; the stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes, although the first site is the most stimulatory.|||Part of the 50S ribosomal subunit, binds large rRNA. Forms the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/70601:PH_RS01595 ^@ http://purl.uniprot.org/uniprot/O58096 ^@ Similarity ^@ Belongs to the UPF0216 family. http://togogenome.org/gene/70601:PH_RS08015 ^@ http://purl.uniprot.org/uniprot/O59361 ^@ Cofactor|||Similarity ^@ Belongs to the UPF0292 family.|||Binds two Mg(2+) per subunit. http://togogenome.org/gene/70601:PH_RS08065 ^@ http://purl.uniprot.org/uniprot/O59406 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS08555 ^@ http://purl.uniprot.org/uniprot/O59479 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/70601:PH_RS03400 ^@ http://purl.uniprot.org/uniprot/O58451 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/70601:PH_RS06060 ^@ http://purl.uniprot.org/uniprot/O59014 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/70601:PH_RS05270 ^@ http://purl.uniprot.org/uniprot/O58854 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/70601:PH_RS00155 ^@ http://purl.uniprot.org/uniprot/O57753 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/70601:PH_RS08425 ^@ http://purl.uniprot.org/uniprot/O74098 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal histone HMF family.|||Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (By similarity).|||Chromosome|||Cytoplasm|||Homodimer (PubMed:12527306). Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity). http://togogenome.org/gene/70601:PH_RS06840 ^@ http://purl.uniprot.org/uniprot/O59119 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS08915 ^@ http://purl.uniprot.org/uniprot/O59530 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS05855 ^@ http://purl.uniprot.org/uniprot/O58938 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/70601:PH_RS05275 ^@ http://purl.uniprot.org/uniprot/O74001 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/70601:PH_RS02075 ^@ http://purl.uniprot.org/uniprot/O58187 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/70601:PH_RS06020 ^@ http://purl.uniprot.org/uniprot/O59023 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the carbamate kinase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS08465 ^@ http://purl.uniprot.org/uniprot/O59456 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer. http://togogenome.org/gene/70601:PH_RS00795 ^@ http://purl.uniprot.org/uniprot/O57914 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/70601:PH_RS07745 ^@ http://purl.uniprot.org/uniprot/P62011 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS05330 ^@ http://purl.uniprot.org/uniprot/O58865 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/70601:PH_RS06990 ^@ http://purl.uniprot.org/uniprot/O59151 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/70601:PH_RS06650 ^@ http://purl.uniprot.org/uniprot/O50116 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP. http://togogenome.org/gene/70601:PH_RS07715 ^@ http://purl.uniprot.org/uniprot/O59298 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/70601:PH_RS06585 ^@ http://purl.uniprot.org/uniprot/O50097 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/70601:PH_RS05360 ^@ http://purl.uniprot.org/uniprot/O58891 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Homohexamer. Dimer of a homotrimer.|||Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. http://togogenome.org/gene/70601:PH_RS06015 ^@ http://purl.uniprot.org/uniprot/O59025 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/70601:PH_RS01320 ^@ http://purl.uniprot.org/uniprot/O58033 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers. http://togogenome.org/gene/70601:PH_RS00570 ^@ http://purl.uniprot.org/uniprot/O57864 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/70601:PH_RS09070 ^@ http://purl.uniprot.org/uniprot/O59580 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/70601:PH_RS00745 ^@ http://purl.uniprot.org/uniprot/O57903 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated Csm2 family.|||This subunit may be involved in monitoring complementarity of crRNA and target RNA. http://togogenome.org/gene/70601:PH_RS08320 ^@ http://purl.uniprot.org/uniprot/O59432 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS02805 ^@ http://purl.uniprot.org/uniprot/O58320 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS05155 ^@ http://purl.uniprot.org/uniprot/O58830 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS03075 ^@ http://purl.uniprot.org/uniprot/O73984 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/70601:PH_RS02450 ^@ http://purl.uniprot.org/uniprot/O58264 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/70601:PH_RS03730 ^@ http://purl.uniprot.org/uniprot/O58524 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/70601:PH_RS06390 ^@ http://purl.uniprot.org/uniprot/O59072 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/70601:PH_RS04920 ^@ http://purl.uniprot.org/uniprot/O58750 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS09440 ^@ http://purl.uniprot.org/uniprot/O57706 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer. http://togogenome.org/gene/70601:PH_RS09390 ^@ http://purl.uniprot.org/uniprot/O57716 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. http://togogenome.org/gene/70601:PH_RS08380 ^@ http://purl.uniprot.org/uniprot/O59422 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/70601:PH_RS09110 ^@ http://purl.uniprot.org/uniprot/O59588 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/70601:PH_RS00435 ^@ http://purl.uniprot.org/uniprot/O57832 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS04430 ^@ http://purl.uniprot.org/uniprot/O58679 ^@ Function|||Similarity|||Subunit ^@ Belongs to the group II decarboxylase family. MfnA subfamily.|||Catalyzes the decarboxylation of L-aspartate to produce beta-alanine, and the decarboxylation of L-glutamate to produce 4-aminobutanoate. Can also use cysteate and, to a lesser extent, cysteine sulfite (3-sulfino-L-alanine), but not L-tyrosine. Specific activities toward L-aspartate and cysteate are higher than toward L-glutamate.|||Monomer. http://togogenome.org/gene/70601:PH_RS08330 ^@ http://purl.uniprot.org/uniprot/O59431 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/70601:PH_RS08170 ^@ http://purl.uniprot.org/uniprot/O59384 ^@ Similarity ^@ Belongs to the aspartate/glutamate racemases family. http://togogenome.org/gene/70601:PH_RS04465 ^@ http://purl.uniprot.org/uniprot/O58674 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS05945 ^@ http://purl.uniprot.org/uniprot/O74006 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/70601:PH_RS09350 ^@ http://purl.uniprot.org/uniprot/O57726 ^@ Function|||Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/70601:PH_RS07000 ^@ http://purl.uniprot.org/uniprot/O59152 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS04075 ^@ http://purl.uniprot.org/uniprot/O58595 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS02570 ^@ http://purl.uniprot.org/uniprot/O58285 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/70601:PH_RS08505 ^@ http://purl.uniprot.org/uniprot/O59468 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/70601:PH_RS07795 ^@ http://purl.uniprot.org/uniprot/O59350 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/70601:PH_RS06570 ^@ http://purl.uniprot.org/uniprot/O50093 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/70601:PH_RS02950 ^@ http://purl.uniprot.org/uniprot/O58362 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/70601:PH_RS05690 ^@ http://purl.uniprot.org/uniprot/P59734 ^@ Similarity ^@ Belongs to the UPF0248 family. http://togogenome.org/gene/70601:PH_RS09215 ^@ http://purl.uniprot.org/uniprot/O59610 ^@ PTM|||Similarity ^@ Belongs to the DNA polymerase type-B family.|||This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation. http://togogenome.org/gene/70601:PH_RS05670 ^@ http://purl.uniprot.org/uniprot/O58974 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/70601:PH_RS09400 ^@ http://purl.uniprot.org/uniprot/O57713 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0104 family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS06615 ^@ http://purl.uniprot.org/uniprot/O50105 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/70601:PH_RS04395 ^@ http://purl.uniprot.org/uniprot/O58687 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/70601:PH_RS05700 ^@ http://purl.uniprot.org/uniprot/O58969 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 1 family.|||Cell membrane|||Probably part of a binding-protein-dependent transport system PH1214/15/16. http://togogenome.org/gene/70601:PH_RS07310 ^@ http://purl.uniprot.org/uniprot/O59226 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/70601:PH_RS07705 ^@ http://purl.uniprot.org/uniprot/P62015 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/70601:PH_RS06855 ^@ http://purl.uniprot.org/uniprot/O59122 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS07075 ^@ http://purl.uniprot.org/uniprot/P62009 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). When added to reconstituted ribonuclease P (RNase P) it increases the optimum temperature to that of the partially purified enzyme and causes a 5-fold increase in apparent Vmax. Binds the RNase P catalytic RNA.|||Part of the 50S ribosomal subunit (By similarity). May be part of the RNase P complex. Reconstituted enzyme missing individual protein subunits is suboptimally active, showing each subunit contributes to optimization of activity. http://togogenome.org/gene/70601:PH_RS07360 ^@ http://purl.uniprot.org/uniprot/O59219 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/70601:PH_RS03720 ^@ http://purl.uniprot.org/uniprot/O58522 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/70601:PH_RS07290 ^@ http://purl.uniprot.org/uniprot/O59228 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/70601:PH_RS04550 ^@ http://purl.uniprot.org/uniprot/O58698 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS08490 ^@ http://purl.uniprot.org/uniprot/O59465 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS02480 ^@ http://purl.uniprot.org/uniprot/O73978 ^@ Similarity ^@ Belongs to the UPF0440 family. http://togogenome.org/gene/70601:PH_RS00920 ^@ http://purl.uniprot.org/uniprot/O57943 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS07255 ^@ http://purl.uniprot.org/uniprot/O59206 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/70601:PH_RS03600 ^@ http://purl.uniprot.org/uniprot/O58491 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/70601:PH_RS07755 ^@ http://purl.uniprot.org/uniprot/O74021 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/70601:PH_RS05055 ^@ http://purl.uniprot.org/uniprot/O58805 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/70601:PH_RS00690 ^@ http://purl.uniprot.org/uniprot/O57890 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.|||Cell membrane|||Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate (By similarity).|||The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA). http://togogenome.org/gene/70601:PH_RS04405 ^@ http://purl.uniprot.org/uniprot/O58683 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/70601:PH_RS05835 ^@ http://purl.uniprot.org/uniprot/O58941 ^@ Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. http://togogenome.org/gene/70601:PH_RS07315 ^@ http://purl.uniprot.org/uniprot/O74019 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/70601:PH_RS03480 ^@ http://purl.uniprot.org/uniprot/O58470 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/70601:PH_RS03310 ^@ http://purl.uniprot.org/uniprot/O58433 ^@ Function|||Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/70601:PH_RS02900 ^@ http://purl.uniprot.org/uniprot/O58353 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/70601:PH_RS03580 ^@ http://purl.uniprot.org/uniprot/O58495 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/70601:PH_RS05010 ^@ http://purl.uniprot.org/uniprot/O58792 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/70601:PH_RS07555 ^@ http://purl.uniprot.org/uniprot/O59251 ^@ Function|||Similarity ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.|||Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. http://togogenome.org/gene/70601:PH_RS02440 ^@ http://purl.uniprot.org/uniprot/O58263 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity). http://togogenome.org/gene/70601:PH_RS03185 ^@ http://purl.uniprot.org/uniprot/O58413 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/70601:PH_RS07085 ^@ http://purl.uniprot.org/uniprot/O59167 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/70601:PH_RS02945 ^@ http://purl.uniprot.org/uniprot/O58361 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Homohexamer. http://togogenome.org/gene/70601:PH_RS00785 ^@ http://purl.uniprot.org/uniprot/O57912 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/70601:PH_RS05300 ^@ http://purl.uniprot.org/uniprot/O58858 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Potential transporter for phosphate. http://togogenome.org/gene/70601:PH_RS08070 ^@ http://purl.uniprot.org/uniprot/O59405 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS03205 ^@ http://purl.uniprot.org/uniprot/O58417 ^@ Cofactor|||Subunit ^@ Binds 1 [4Fe-4S] cluster per subunit.|||Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/70601:PH_RS00825 ^@ http://purl.uniprot.org/uniprot/O57921 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/70601:PH_RS09250 ^@ http://purl.uniprot.org/uniprot/O59619 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/70601:PH_RS07515 ^@ http://purl.uniprot.org/uniprot/O59258 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer. http://togogenome.org/gene/70601:PH_RS08040 ^@ http://purl.uniprot.org/uniprot/O59413 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C56 family.|||Cytoplasm|||Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (By similarity). Also displays proteolytic activity (PubMed:11114201).|||Homohexamer formed by a dimer of trimers that assemble into a hollow ring structure. http://togogenome.org/gene/70601:PH_RS01615 ^@ http://purl.uniprot.org/uniprot/O58099 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS05955 ^@ http://purl.uniprot.org/uniprot/P59937 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/70601:PH_RS04880 ^@ http://purl.uniprot.org/uniprot/O58759 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.|||Cell membrane|||Probably part of a binding-protein-dependent transport system PH1036/38/39. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/70601:PH_RS03555 ^@ http://purl.uniprot.org/uniprot/O58499 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS08025 ^@ http://purl.uniprot.org/uniprot/O74092 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal histone HMF family.|||Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (By similarity).|||Chromosome|||Cytoplasm|||Homodimer or heterodimer with another histone. Dimers then assemble into higher oligomers, with the DNA wrapped around the protein core (By similarity). http://togogenome.org/gene/70601:PH_RS02920 ^@ http://purl.uniprot.org/uniprot/O58356 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Binds two Mg(2+) per subunit.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/70601:PH_RS02340 ^@ http://purl.uniprot.org/uniprot/O58237 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/70601:PH_RS07500 ^@ http://purl.uniprot.org/uniprot/O59261 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/70601:PH_RS08325 ^@ http://purl.uniprot.org/uniprot/P62013 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS03570 ^@ http://purl.uniprot.org/uniprot/O58497 ^@ Function|||Similarity ^@ Belongs to the Tfx family.|||Putative transcriptional regulator. http://togogenome.org/gene/70601:PH_RS01400 ^@ http://purl.uniprot.org/uniprot/O58050 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS09425 ^@ http://purl.uniprot.org/uniprot/O57708 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/70601:PH_RS08630 ^@ http://purl.uniprot.org/uniprot/O74099 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/70601:PH_RS06590 ^@ http://purl.uniprot.org/uniprot/O50098 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS08270 ^@ http://purl.uniprot.org/uniprot/O59444 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS03130 ^@ http://purl.uniprot.org/uniprot/O58403 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the aspartate/glutamate racemases family.|||Homodimer. The existence of the interchain disulfide bond seen in the crystal structures is uncertain, but disulfide bonds have been reported for cytoplasmic proteins from thermophiles.|||Weakly inhibited by citrate, but not by asparagine. http://togogenome.org/gene/70601:PH_RS03470 ^@ http://purl.uniprot.org/uniprot/O58468 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/70601:PH_RS07405 ^@ http://purl.uniprot.org/uniprot/O74020 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/70601:PH_RS03945 ^@ http://purl.uniprot.org/uniprot/O58565 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/70601:PH_RS07695 ^@ http://purl.uniprot.org/uniprot/O59295 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/70601:PH_RS00100 ^@ http://purl.uniprot.org/uniprot/O57762 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Forms an oligomeric complex of eight-membered rings.|||Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity. http://togogenome.org/gene/70601:PH_RS00800 ^@ http://purl.uniprot.org/uniprot/O57915 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/70601:PH_RS01335 ^@ http://purl.uniprot.org/uniprot/O58035 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Edits incorrectly charged Ser-tRNA(Ala). Incorrectly charged amino acids occur because the of inherent physicochemical limitations on discrimination between closely related amino acids (Gly and Ser) in the charging step.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs (By similarity).|||Cytoplasm|||Homodimer.|||Unlike the case in Archaeoglobus fulgidus and some of the free-standing tRNA(Ala) AlaX editing proteins, His-721 does not bind zinc but forms a hydrogen bond with Cys-717 instead. http://togogenome.org/gene/70601:PH_RS04490 ^@ http://purl.uniprot.org/uniprot/O58669 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 2 residues (Tyr-64 and Arg-67) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.|||Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. http://togogenome.org/gene/70601:PH_RS03065 ^@ http://purl.uniprot.org/uniprot/O58388 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS00530 ^@ http://purl.uniprot.org/uniprot/O57854 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. http://togogenome.org/gene/70601:PH_RS02330 ^@ http://purl.uniprot.org/uniprot/O58236 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PINc/VapC protein family.|||Homodimer.|||Toxic component of a type II toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/70601:PH_RS02965 ^@ http://purl.uniprot.org/uniprot/O58366 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS08300 ^@ http://purl.uniprot.org/uniprot/O59438 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/70601:PH_RS03405 ^@ http://purl.uniprot.org/uniprot/O58452 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/70601:PH_RS04860 ^@ http://purl.uniprot.org/uniprot/O58764 ^@ Similarity ^@ Belongs to the UPF0310 family. http://togogenome.org/gene/70601:PH_RS06330 ^@ http://purl.uniprot.org/uniprot/O59060 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CetZ family.|||Cytoplasm|||Involved in cell shape control. http://togogenome.org/gene/70601:PH_RS07230 ^@ http://purl.uniprot.org/uniprot/O59200 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS08540 ^@ http://purl.uniprot.org/uniprot/O59475 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/70601:PH_RS00610 ^@ http://purl.uniprot.org/uniprot/O57872 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). http://togogenome.org/gene/70601:PH_RS08130 ^@ http://purl.uniprot.org/uniprot/O59391 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/70601:PH_RS06660 ^@ http://purl.uniprot.org/uniprot/O50118 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS03520 ^@ http://purl.uniprot.org/uniprot/O58509 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/70601:PH_RS07725 ^@ http://purl.uniprot.org/uniprot/O59300 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/70601:PH_RS00890 ^@ http://purl.uniprot.org/uniprot/O57935 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/70601:PH_RS06425 ^@ http://purl.uniprot.org/uniprot/O59080 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||Homohexamer. In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/70601:PH_RS07730 ^@ http://purl.uniprot.org/uniprot/O59302 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/70601:PH_RS06665 ^@ http://purl.uniprot.org/uniprot/O50119 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS08560 ^@ http://purl.uniprot.org/uniprot/O59480 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS05435 ^@ http://purl.uniprot.org/uniprot/O58875 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/70601:PH_RS00145 ^@ http://purl.uniprot.org/uniprot/P58748 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/70601:PH_RS06745 ^@ http://purl.uniprot.org/uniprot/O59098 ^@ Similarity ^@ Belongs to the UPF0091 family. http://togogenome.org/gene/70601:PH_RS06005 ^@ http://purl.uniprot.org/uniprot/O59028 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH2/MDH2 oxidoreductase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS01295 ^@ http://purl.uniprot.org/uniprot/O58027 ^@ Similarity ^@ Belongs to the GbsR family. http://togogenome.org/gene/70601:PH_RS08675 ^@ http://purl.uniprot.org/uniprot/O59517 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/70601:PH_RS04375 ^@ http://purl.uniprot.org/uniprot/O58690 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. MPGP family.|||Cytoplasm|||Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). The enzyme is absolutely specific for MPG. http://togogenome.org/gene/70601:PH_RS07300 ^@ http://purl.uniprot.org/uniprot/O93777 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/70601:PH_RS04725 ^@ http://purl.uniprot.org/uniprot/O58730 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/70601:PH_RS07340 ^@ http://purl.uniprot.org/uniprot/O59224 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/70601:PH_RS09365 ^@ http://purl.uniprot.org/uniprot/O57721 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/70601:PH_RS09240 ^@ http://purl.uniprot.org/uniprot/O59621 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/70601:PH_RS07415 ^@ http://purl.uniprot.org/uniprot/O59281 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/70601:PH_RS00725 ^@ http://purl.uniprot.org/uniprot/O57898 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane|||Probable biotin transporter. http://togogenome.org/gene/70601:PH_RS05900 ^@ http://purl.uniprot.org/uniprot/O58998 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/70601:PH_RS07605 ^@ http://purl.uniprot.org/uniprot/O59240 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/70601:PH_RS04955 ^@ http://purl.uniprot.org/uniprot/O58783 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/70601:PH_RS08105 ^@ http://purl.uniprot.org/uniprot/O59397 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. http://togogenome.org/gene/70601:PH_RS06310 ^@ http://purl.uniprot.org/uniprot/O59038 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/70601:PH_RS09190 ^@ http://purl.uniprot.org/uniprot/O59603 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS05715 ^@ http://purl.uniprot.org/uniprot/O58966 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.|||Up-regulated by exposure to oxygen (at protein level). http://togogenome.org/gene/70601:PH_RS01405 ^@ http://purl.uniprot.org/uniprot/O58052 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/70601:PH_RS07505 ^@ http://purl.uniprot.org/uniprot/O59260 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/70601:PH_RS03090 ^@ http://purl.uniprot.org/uniprot/O58394 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/70601:PH_RS02820 ^@ http://purl.uniprot.org/uniprot/O58316 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family.|||Binds 1 nickel ion per subunit.|||Transcriptional regulator. http://togogenome.org/gene/70601:PH_RS03290 ^@ http://purl.uniprot.org/uniprot/O58429 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/70601:PH_RS00810 ^@ http://purl.uniprot.org/uniprot/O57917 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/70601:PH_RS05105 ^@ http://purl.uniprot.org/uniprot/O58816 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal MetE family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. http://togogenome.org/gene/70601:PH_RS07220 ^@ http://purl.uniprot.org/uniprot/O59198 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).|||Cytoplasm http://togogenome.org/gene/70601:PH_RS07070 ^@ http://purl.uniprot.org/uniprot/P61030 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/70601:PH_RS09260 ^@ http://purl.uniprot.org/uniprot/O59618 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal-type GPI family.|||Binds 1 Fe cation per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS03540 ^@ http://purl.uniprot.org/uniprot/O58504 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS01440 ^@ http://purl.uniprot.org/uniprot/O58056 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. http://togogenome.org/gene/70601:PH_RS02155 ^@ http://purl.uniprot.org/uniprot/O58216 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro. http://togogenome.org/gene/70601:PH_RS01120 ^@ http://purl.uniprot.org/uniprot/O57983 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/70601:PH_RS08295 ^@ http://purl.uniprot.org/uniprot/O59439 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/70601:PH_RS03705 ^@ http://purl.uniprot.org/uniprot/O58518 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/70601:PH_RS05655 ^@ http://purl.uniprot.org/uniprot/O58977 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS08310 ^@ http://purl.uniprot.org/uniprot/O59435 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/70601:PH_RS00350 ^@ http://purl.uniprot.org/uniprot/O57792 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/70601:PH_RS07525 ^@ http://purl.uniprot.org/uniprot/O59256 ^@ Function|||Subunit ^@ DNA-binding protein that negatively regulates its own transcription. Interferes with RNA polymerase (RNAP) recruitment by inhibiting the association of RNAP with the TBP-TFB promoter complex.|||Homooctamer; tetramer of dimers. http://togogenome.org/gene/70601:PH_RS03110 ^@ http://purl.uniprot.org/uniprot/O58398 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/70601:PH_RS07630 ^@ http://purl.uniprot.org/uniprot/O59235 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm http://togogenome.org/gene/70601:PH_RS00650 ^@ http://purl.uniprot.org/uniprot/O57887 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/70601:PH_RS03140 ^@ http://purl.uniprot.org/uniprot/O58405 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0252 family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS03775 ^@ http://purl.uniprot.org/uniprot/O58533 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/70601:PH_RS03510 ^@ http://purl.uniprot.org/uniprot/O58512 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 65 family. http://togogenome.org/gene/70601:PH_RS05740 ^@ http://purl.uniprot.org/uniprot/O58960 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/70601:PH_RS03735 ^@ http://purl.uniprot.org/uniprot/O58525 ^@ Similarity ^@ Belongs to the UPF0148 family. http://togogenome.org/gene/70601:PH_RS07175 ^@ http://purl.uniprot.org/uniprot/O74016 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/70601:PH_RS02165 ^@ http://purl.uniprot.org/uniprot/O58214 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/70601:PH_RS01630 ^@ http://purl.uniprot.org/uniprot/O58104 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/70601:PH_RS00555 ^@ http://purl.uniprot.org/uniprot/O57860 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/70601:PH_RS02525 ^@ http://purl.uniprot.org/uniprot/O58275 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/70601:PH_RS08375 ^@ http://purl.uniprot.org/uniprot/O59423 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/70601:PH_RS03725 ^@ http://purl.uniprot.org/uniprot/O58523 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). http://togogenome.org/gene/70601:PH_RS07265 ^@ http://purl.uniprot.org/uniprot/O59207 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/70601:PH_RS00025 ^@ http://purl.uniprot.org/uniprot/O57776 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/70601:PH_RS08125 ^@ http://purl.uniprot.org/uniprot/O59393 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/70601:PH_RS04750 ^@ http://purl.uniprot.org/uniprot/O58736 ^@ Similarity ^@ Belongs to the UPF0200 family. http://togogenome.org/gene/70601:PH_RS07750 ^@ http://purl.uniprot.org/uniprot/O59306 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/70601:PH_RS07670 ^@ http://purl.uniprot.org/uniprot/O59288 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/70601:PH_RS01625 ^@ http://purl.uniprot.org/uniprot/O58103 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/70601:PH_RS06975 ^@ http://purl.uniprot.org/uniprot/O59147 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS08600 ^@ http://purl.uniprot.org/uniprot/O59488 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/70601:PH_RS02135 ^@ http://purl.uniprot.org/uniprot/O58221 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity).|||Belongs to the peptidase S16 family. Archaeal LonB subfamily.|||Cell membrane|||Homohexamer. Organized in a ring with a central cavity (By similarity).|||This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation. http://togogenome.org/gene/70601:PH_RS02300 ^@ http://purl.uniprot.org/uniprot/O58227 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/70601:PH_RS09345 ^@ http://purl.uniprot.org/uniprot/O57727 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/70601:PH_RS02350 ^@ http://purl.uniprot.org/uniprot/O58239 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS03435 ^@ http://purl.uniprot.org/uniprot/O58459 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the branched-chain polyamine synthase family.|||Cytoplasm|||Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine. http://togogenome.org/gene/70601:PH_RS02855 ^@ http://purl.uniprot.org/uniprot/O58310 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/70601:PH_RS07105 ^@ http://purl.uniprot.org/uniprot/O59172 ^@ Similarity ^@ Belongs to the UPF0166 family. http://togogenome.org/gene/70601:PH_RS00245 ^@ http://purl.uniprot.org/uniprot/O57811 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/70601:PH_RS01275 ^@ http://purl.uniprot.org/uniprot/O58022 ^@ Similarity ^@ Belongs to the UPF0273 family. http://togogenome.org/gene/70601:PH_RS05375 ^@ http://purl.uniprot.org/uniprot/O58888 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/70601:PH_RS00885 ^@ http://purl.uniprot.org/uniprot/O57934 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (PubMed:14750947). http://togogenome.org/gene/70601:PH_RS00870 ^@ http://purl.uniprot.org/uniprot/O57930 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/70601:PH_RS08545 ^@ http://purl.uniprot.org/uniprot/O59476 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS06705 ^@ http://purl.uniprot.org/uniprot/O50128 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/70601:PH_RS05450 ^@ http://purl.uniprot.org/uniprot/O58872 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS04240 ^@ http://purl.uniprot.org/uniprot/O58636 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/70601:PH_RS09185 ^@ http://purl.uniprot.org/uniprot/P58078 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/70601:PH_RS02685 ^@ http://purl.uniprot.org/uniprot/O58307 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Editing domain AlaX-S subfamily.|||Binds 1 zinc ion per subunit; the homodimer seems not to bind zinc. The zinc is probably not catalytic (PubMed:16087889). Another report suggests the zinc is catalytic (PubMed:16374837).|||Cytoplasm|||Functions in trans to edit the amino acid moiety from mischarged charged Ser-tRNA(Ala). Has little activity against Gly-tRNA(Ala).|||Monomer and homodimer; the dimer is less active in tRNA editing and does not have a zinc ion associated with it (PubMed:16087889). Another report shows only a monomeric form (PubMed:16374837). http://togogenome.org/gene/70601:PH_RS06085 ^@ http://purl.uniprot.org/uniprot/O59010 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Cell membrane|||Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, regions involved in trimerization do not move.|||Homotrimer.|||Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583). http://togogenome.org/gene/70601:PH_RS02410 ^@ http://purl.uniprot.org/uniprot/O58256 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/70601:PH_RS00080 ^@ http://purl.uniprot.org/uniprot/O57767 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the quinolinate synthase family. Type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Contains three domains displaying pseudo-three-fold symmetry that each contribute a cysteine residue for ligation to a centrally located [4Fe-4S] cluster.|||Cytoplasm|||Monomer (PubMed:15937336). Homodimer (PubMed:27224840). http://togogenome.org/gene/70601:PH_RS04475 ^@ http://purl.uniprot.org/uniprot/O58672 ^@ Similarity ^@ Belongs to the UPF0091 family. http://togogenome.org/gene/70601:PH_RS04685 ^@ http://purl.uniprot.org/uniprot/O58721 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/70601:PH_RS04370 ^@ http://purl.uniprot.org/uniprot/O58649 ^@ Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 2 family. http://togogenome.org/gene/70601:PH_RS08280 ^@ http://purl.uniprot.org/uniprot/O59442 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/70601:PH_RS08345 ^@ http://purl.uniprot.org/uniprot/O59427 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/70601:PH_RS09380 ^@ http://purl.uniprot.org/uniprot/O57718 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Involved in protein export.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the protein translocation apparatus. Forms a complex with SecF. http://togogenome.org/gene/70601:PH_RS04150 ^@ http://purl.uniprot.org/uniprot/O58609 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/70601:PH_RS00925 ^@ http://purl.uniprot.org/uniprot/O57944 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS07350 ^@ http://purl.uniprot.org/uniprot/O59221 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/70601:PH_RS07675 ^@ http://purl.uniprot.org/uniprot/O59289 ^@ Function|||Similarity|||Subunit ^@ Belongs to the isopentenyl phosphate kinase family.|||Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.|||Homodimer. http://togogenome.org/gene/70601:PH_RS06290 ^@ http://purl.uniprot.org/uniprot/O59041 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS00590 ^@ http://purl.uniprot.org/uniprot/O57868 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS01110 ^@ http://purl.uniprot.org/uniprot/O57981 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS04620 ^@ http://purl.uniprot.org/uniprot/O58708 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/70601:PH_RS02175 ^@ http://purl.uniprot.org/uniprot/O58212 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family.|||Catalyzes the hydrolysis of S-adenosyl-L-methionine (SAM) into adenosine and L-methionine (PubMed:18551689). Is likely stereoselective, specifically hydrolyzing (R)-S-adenosyl-L-methionine ((R)-SAM), the inactive form of the ubiquitous cofactor SAM, and not the active form of SAM, (S)-S-adenosyl-L-methionine (By similarity). Probaly plays a role in preventing accumulation of (R)-S-adenosyl-L-methionine in cells; maintenance of (S)-S-denosyl-L-methionine homochirality is important for cellular health given that the (R)-form is largely inactive as a methyl donor and can function as an inhibitor of methyltransferases (By similarity). Is unable to mediate a fluorination or chlorination reaction with SAM (PubMed:18551689).|||Homotrimer. http://togogenome.org/gene/70601:PH_RS01230 ^@ http://purl.uniprot.org/uniprot/O58012 ^@ Function|||Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.|||May have GTPase activity. May also bind and hydrolyze ATP. May function as chaperone (By similarity). http://togogenome.org/gene/70601:PH_RS06575 ^@ http://purl.uniprot.org/uniprot/O50094 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/70601:PH_RS04470 ^@ http://purl.uniprot.org/uniprot/O58673 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS04535 ^@ http://purl.uniprot.org/uniprot/O58655 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/70601:PH_RS04025 ^@ http://purl.uniprot.org/uniprot/O58586 ^@ Similarity ^@ Belongs to the flavoredoxin family. http://togogenome.org/gene/70601:PH_RS02145 ^@ http://purl.uniprot.org/uniprot/O58218 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/70601:PH_RS02180 ^@ http://purl.uniprot.org/uniprot/O58211 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS03910 ^@ http://purl.uniprot.org/uniprot/O58558 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Putative gamma-glutamylcyclotransferase. http://togogenome.org/gene/70601:PH_RS00310 ^@ http://purl.uniprot.org/uniprot/O57798 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS05905 ^@ http://purl.uniprot.org/uniprot/O58997 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane http://togogenome.org/gene/70601:PH_RS09200 ^@ http://purl.uniprot.org/uniprot/O59605 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/70601:PH_RS07940 ^@ http://purl.uniprot.org/uniprot/O59317 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/70601:PH_RS07065 ^@ http://purl.uniprot.org/uniprot/P61124 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/70601:PH_RS00415 ^@ http://purl.uniprot.org/uniprot/O57836 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/70601:PH_RS00405 ^@ http://purl.uniprot.org/uniprot/O57839 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the arginase family. Agmatinase subfamily.|||Binds 2 divalent metal cations per subunit (By similarity). Co(2+) is the most effection cation. Can also use Ca(2+), Mn(2+), Zn(2+) or Mg(2+) (PubMed:15752699).|||Catalyzes the formation of putrescine from agmatine. Cannot use arginine.|||Homotetramer.|||Inhibited by putrescine. Activity is not affected by arginine and ornithine. http://togogenome.org/gene/70601:PH_RS03340 ^@ http://purl.uniprot.org/uniprot/O58440 ^@ Cofactor|||Domain|||Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Binds 1 zinc ion per subunit.|||Has 2 structurally independent domains; the N-terminal PINc domain which binds Mn(2+), rRNA substrate and probably has endoribonuclease activity, and the C-terminal zinc ribbon domain which also binds rRNA substrate.|||Manganese; magnesium does not support nuclease activity.|||Toxic component of a type II toxin-antitoxin (TA) system (Potential). Processes pre-16S-rRNA at its 3' end (the D-site) to yield the mature 3' end. http://togogenome.org/gene/70601:PH_RS02560 ^@ http://purl.uniprot.org/uniprot/O58283 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/70601:PH_RS07805 ^@ http://purl.uniprot.org/uniprot/O59347 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS09165 ^@ http://purl.uniprot.org/uniprot/O59599 ^@ Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro. http://togogenome.org/gene/70601:PH_RS07345 ^@ http://purl.uniprot.org/uniprot/O59223 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS02530 ^@ http://purl.uniprot.org/uniprot/O58276 ^@ Similarity ^@ Belongs to the archaeal ATPase family. http://togogenome.org/gene/70601:PH_RS03685 ^@ http://purl.uniprot.org/uniprot/O58474 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS02970 ^@ http://purl.uniprot.org/uniprot/O58367 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/70601:PH_RS03530 ^@ http://purl.uniprot.org/uniprot/O58506 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS05805 ^@ http://purl.uniprot.org/uniprot/O58947 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/70601:PH_RS08615 ^@ http://purl.uniprot.org/uniprot/O59491 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/70601:PH_RS08150 ^@ http://purl.uniprot.org/uniprot/O59386 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/70601:PH_RS00210 ^@ http://purl.uniprot.org/uniprot/O57820 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/70601:PH_RS02980 ^@ http://purl.uniprot.org/uniprot/O58369 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/70601:PH_RS00750 ^@ http://purl.uniprot.org/uniprot/O57904 ^@ Similarity ^@ Belongs to the CRISPR-associated Csm3 family. http://togogenome.org/gene/70601:PH_RS08905 ^@ http://purl.uniprot.org/uniprot/O59533 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/70601:PH_RS03560 ^@ http://purl.uniprot.org/uniprot/O58498 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/70601:PH_RS05890 ^@ http://purl.uniprot.org/uniprot/O58930 ^@ Similarity ^@ Belongs to the NodU/CmcH family. http://togogenome.org/gene/70601:PH_RS03460 ^@ http://purl.uniprot.org/uniprot/O58466 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal FAD synthase family.|||Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.|||Homodimer. http://togogenome.org/gene/70601:PH_RS03345 ^@ http://purl.uniprot.org/uniprot/O58441 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/70601:PH_RS02880 ^@ http://purl.uniprot.org/uniprot/O58348 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS08385 ^@ http://purl.uniprot.org/uniprot/O59421 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/70601:PH_RS00975 ^@ http://purl.uniprot.org/uniprot/O57953 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS08485 ^@ http://purl.uniprot.org/uniprot/O59462 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/70601:PH_RS07445 ^@ http://purl.uniprot.org/uniprot/O59272 ^@ Activity Regulation|||Cofactor|||Domain|||Function|||Similarity ^@ Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+), Mn(2+), Ca(2+), Zn(2+) and Cu(2+) (PubMed:27322068). Activity is inhibited by EDTA (PubMed:27322068).|||Belongs to the damage-control phosphatase family. Nucleotides phosphatase I subfamily.|||Metal-dependent phosphatase with probable damage-control functions (PubMed:27322068). Shows phosphatase activity against p-nitrophenyl phosphate (pNPP), but natural substrates have not been identified yet (PubMed:27322068). Low phosphatase activity against 8-oxo nucleotides suggests that it could hydrolyze oxidatively damaged purine nucleotides or their biosynthetic intermediates (PubMed:27322068).|||Phosphatase activity is strongly promoted by several divalent cation ions but it is suggested that Mn(2+) and possibly Ni(2+) represent biologically relevant metal ion cofactors for damage-control phosphatase activity (PubMed:27322068).|||Subfamily I proteins are distinguished by three conserved motifs: the CxxC motif localized near the N-terminus, the GNFE motif localized about 40 residues from the C-terminus, and the KC motif localized about 25 residues from the C-terminus (Probable). In the crystal structures of the subfamily I proteins, the side chains of the cysteines in the CxxC and KC motifs face each other across the rim of the putative substrate-binding cleft, and the GNFE motif lies deep in the cleft close to the metal-binding aspartate and asparagine (Probable). the 3 conserved cysteines in motifs CxxC and KC play a key role in the interaction with the Fe-containing chromophore, which is not directly involved in catalysis (Probable).|||The [2Fe-2S] cluster does not seem to be directly involved in catalysis (PubMed:27322068). http://togogenome.org/gene/70601:PH_RS02400 ^@ http://purl.uniprot.org/uniprot/O58254 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS06760 ^@ http://purl.uniprot.org/uniprot/O59099 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS00560 ^@ http://purl.uniprot.org/uniprot/O57861 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the archaeal DNA polymerase II family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).|||This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation. http://togogenome.org/gene/70601:PH_RS05035 ^@ http://purl.uniprot.org/uniprot/O58799 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/70601:PH_RS06030 ^@ http://purl.uniprot.org/uniprot/O59022 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS07470 ^@ http://purl.uniprot.org/uniprot/O59267 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/70601:PH_RS03710 ^@ http://purl.uniprot.org/uniprot/O58520 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/70601:PH_RS01470 ^@ http://purl.uniprot.org/uniprot/O58063 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS00200 ^@ http://purl.uniprot.org/uniprot/P57671 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/70601:PH_RS05200 ^@ http://purl.uniprot.org/uniprot/O58839 ^@ Similarity ^@ Belongs to the UPF0127 family. http://togogenome.org/gene/70601:PH_RS06165 ^@ http://purl.uniprot.org/uniprot/P62007 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/70601:PH_RS09180 ^@ http://purl.uniprot.org/uniprot/O59602 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the PTPS family. QueD subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.|||The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity). http://togogenome.org/gene/70601:PH_RS08275 ^@ http://purl.uniprot.org/uniprot/O59443 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS04365 ^@ http://purl.uniprot.org/uniprot/O58651 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/70601:PH_RS09030 ^@ http://purl.uniprot.org/uniprot/O59572 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/70601:PH_RS03100 ^@ http://purl.uniprot.org/uniprot/O58397 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/70601:PH_RS00945 ^@ http://purl.uniprot.org/uniprot/O57948 ^@ Similarity ^@ Belongs to the UPF0146 family. http://togogenome.org/gene/70601:PH_RS04485 ^@ http://purl.uniprot.org/uniprot/O58670 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS01560 ^@ http://purl.uniprot.org/uniprot/O58088 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), also called psiRNA (prokaryotic silencing) in this organism (Potential).|||Monomer; homodimer when crystallized in the presence of crRNA. Varying the crRNA sequence varies degree of oligomerization and structure.|||No in vitro nuclease activity has been observed against crRNA for this protein. http://togogenome.org/gene/70601:PH_RS04010 ^@ http://purl.uniprot.org/uniprot/O58582 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site (By similarity). http://togogenome.org/gene/70601:PH_RS09090 ^@ http://purl.uniprot.org/uniprot/O59584 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS04865 ^@ http://purl.uniprot.org/uniprot/O58763 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/70601:PH_RS09300 ^@ http://purl.uniprot.org/uniprot/O57738 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/70601:PH_RS02275 ^@ http://purl.uniprot.org/uniprot/O58192 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CheB family.|||Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.|||Cytoplasm|||Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.|||Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity. http://togogenome.org/gene/70601:PH_RS03765 ^@ http://purl.uniprot.org/uniprot/O58530 ^@ Cofactor|||Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subunit ^@ Binds two Mg(2+) per subunit.|||Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain (By similarity).|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity).|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.|||This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation. http://togogenome.org/gene/70601:PH_RS04185 ^@ http://purl.uniprot.org/uniprot/O58647 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS06645 ^@ http://purl.uniprot.org/uniprot/O50114 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/70601:PH_RS05720 ^@ http://purl.uniprot.org/uniprot/O58965 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS04810 ^@ http://purl.uniprot.org/uniprot/O58776 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS02850 ^@ http://purl.uniprot.org/uniprot/O58312 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/70601:PH_RS06635 ^@ http://purl.uniprot.org/uniprot/O50110 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/70601:PH_RS06550 ^@ http://purl.uniprot.org/uniprot/O50089 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/70601:PH_RS08495 ^@ http://purl.uniprot.org/uniprot/O59466 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS07005 ^@ http://purl.uniprot.org/uniprot/O59153 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/70601:PH_RS05675 ^@ http://purl.uniprot.org/uniprot/O58973 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/70601:PH_RS00400 ^@ http://purl.uniprot.org/uniprot/O57840 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by citrate.|||Belongs to the DeoC/FbaB aldolase family.|||Cytoplasm|||Homooctamer. http://togogenome.org/gene/70601:PH_RS05710 ^@ http://purl.uniprot.org/uniprot/O58967 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.|||Cell membrane|||Probably part of a binding-protein-dependent transport system PH1214/15/16. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/70601:PH_RS04855 ^@ http://purl.uniprot.org/uniprot/O58765 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/70601:PH_RS01375 ^@ http://purl.uniprot.org/uniprot/O58045 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/70601:PH_RS03845 ^@ http://purl.uniprot.org/uniprot/O58546 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS01685 ^@ http://purl.uniprot.org/uniprot/O58114 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. http://togogenome.org/gene/70601:PH_RS05430 ^@ http://purl.uniprot.org/uniprot/O58877 ^@ Function|||Similarity ^@ Belongs to the Thz kinase family.|||Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). http://togogenome.org/gene/70601:PH_RS08710 ^@ http://purl.uniprot.org/uniprot/O59509 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS02475 ^@ http://purl.uniprot.org/uniprot/O58268 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity). http://togogenome.org/gene/70601:PH_RS08335 ^@ http://purl.uniprot.org/uniprot/O59430 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/70601:PH_RS08120 ^@ http://purl.uniprot.org/uniprot/O59394 ^@ Function|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Catalyzes the NAD(+)-dependent oxidative decarboxylation of homoisocitrate to 2-oxoadipate (alpha-ketoadipate), and of isocitrate to 2-oxoglutarate, at near equal efficiency. May thus play a dual role in glutamate and lysine biosynthesis in vivo. Preferentially uses NAD over NADP. http://togogenome.org/gene/70601:PH_RS06735 ^@ http://purl.uniprot.org/uniprot/O59097 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS07130 ^@ http://purl.uniprot.org/uniprot/O59179 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Homodimer.|||Inhibited by divalent metal cations, including Mg(2+), Mn(2+), Ca(2+) and Zn(2+). Mildly inhibited by 0.01 % SDS and 0.1% dodecyl-beta-D-maltoside. Activity is nearly abolished by 1 % SDS.|||Membrane|||Protease that cleaves its substrates preferentially near hydrophobic or aromatic amino acid residues. Can degrade casein and the stomatin homolog PH1511 (in vitro). http://togogenome.org/gene/70601:PH_RS03295 ^@ http://purl.uniprot.org/uniprot/O58430 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).|||Cytoplasm|||Homodimer.|||The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself. http://togogenome.org/gene/70601:PH_RS07775 ^@ http://purl.uniprot.org/uniprot/O59355 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carbohydrate kinase PfkC family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS09050 ^@ http://purl.uniprot.org/uniprot/O59575 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS00480 ^@ http://purl.uniprot.org/uniprot/O57823 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/70601:PH_RS08365 ^@ http://purl.uniprot.org/uniprot/O74094 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/70601:PH_RS09330 ^@ http://purl.uniprot.org/uniprot/O57731 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/70601:PH_RS00720 ^@ http://purl.uniprot.org/uniprot/O57896 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.|||Cell membrane|||Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA). http://togogenome.org/gene/70601:PH_RS00010 ^@ http://purl.uniprot.org/uniprot/O57779 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/70601:PH_RS08680 ^@ http://purl.uniprot.org/uniprot/O74101 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/70601:PH_RS08750 ^@ http://purl.uniprot.org/uniprot/O59500 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/70601:PH_RS01765 ^@ http://purl.uniprot.org/uniprot/O58127 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS06480 ^@ http://purl.uniprot.org/uniprot/O59090 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS08290 ^@ http://purl.uniprot.org/uniprot/O59440 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS06870 ^@ http://purl.uniprot.org/uniprot/O59124 ^@ Similarity ^@ Belongs to the UPF0091 family. http://togogenome.org/gene/70601:PH_RS03080 ^@ http://purl.uniprot.org/uniprot/O58391 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/70601:PH_RS07355 ^@ http://purl.uniprot.org/uniprot/O59220 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/70601:PH_RS06595 ^@ http://purl.uniprot.org/uniprot/O50099 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/70601:PH_RS09035 ^@ http://purl.uniprot.org/uniprot/P58746 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/70601:PH_RS05985 ^@ http://purl.uniprot.org/uniprot/O58981 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Cell membrane|||Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.|||Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (ManNAcXyl(2)GlcAMan(2)GalNAc in Pyrococcus) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. http://togogenome.org/gene/70601:PH_RS03450 ^@ http://purl.uniprot.org/uniprot/O58462 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/70601:PH_RS06420 ^@ http://purl.uniprot.org/uniprot/O59079 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/70601:PH_RS04805 ^@ http://purl.uniprot.org/uniprot/O58778 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the AOR/FOR family.|||Binds 1 W-bis(molybdopterin guanine dinucleotide) (W-bis-MGD) cofactor per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Homodimer. http://togogenome.org/gene/70601:PH_RS00875 ^@ http://purl.uniprot.org/uniprot/O57932 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/70601:PH_RS01345 ^@ http://purl.uniprot.org/uniprot/O58038 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the TtcA family. TtuA subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe with a free coordination site may bind a small ligand, such as exogenous sulfide, thus acting as a sulfur carrier.|||Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T) (PubMed:28655838). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro, which may be also the sulfur source in vivo (PubMed:28655838).|||Homodimer.|||In TtuA from T.thermophilus, the sulfur inserted into the nucleoside comes from the C-terminal thiocarboxylate of TtuB, but there is no TtuB ortholog in P.horikoshii. Free sulfide has been shown to be present at relatively high concentrations within thermophilic archaea, and may be the sulfur source in vivo.|||The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster. http://togogenome.org/gene/70601:PH_RS07995 ^@ http://purl.uniprot.org/uniprot/O59366 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/70601:PH_RS07100 ^@ http://purl.uniprot.org/uniprot/O59171 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.|||Cell membrane|||Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. http://togogenome.org/gene/70601:PH_RS02575 ^@ http://purl.uniprot.org/uniprot/O58286 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Archaeal flagellum|||Belongs to the archaeal flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella. http://togogenome.org/gene/70601:PH_RS04610 ^@ http://purl.uniprot.org/uniprot/O58706 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/70601:PH_RS06620 ^@ http://purl.uniprot.org/uniprot/O50107 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/70601:PH_RS05950 ^@ http://purl.uniprot.org/uniprot/O58988 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS06630 ^@ http://purl.uniprot.org/uniprot/O50109 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. http://togogenome.org/gene/70601:PH_RS01645 ^@ http://purl.uniprot.org/uniprot/O58107 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. GalK subfamily.|||Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).|||Cytoplasm http://togogenome.org/gene/70601:PH_RS08370 ^@ http://purl.uniprot.org/uniprot/O59424 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS07170 ^@ http://purl.uniprot.org/uniprot/P62005 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA. http://togogenome.org/gene/70601:PH_RS01410 ^@ http://purl.uniprot.org/uniprot/O58054 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS03200 ^@ http://purl.uniprot.org/uniprot/O73986 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/70601:PH_RS08185 ^@ http://purl.uniprot.org/uniprot/O59381 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS05080 ^@ http://purl.uniprot.org/uniprot/O58810 ^@ Function|||Similarity|||Subunit ^@ Belongs to the desulfoferrodoxin family.|||Homotetramer.|||Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide. http://togogenome.org/gene/70601:PH_RS05875 ^@ http://purl.uniprot.org/uniprot/O58933 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/70601:PH_RS08215 ^@ http://purl.uniprot.org/uniprot/O59374 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/70601:PH_RS06685 ^@ http://purl.uniprot.org/uniprot/O50123 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity). http://togogenome.org/gene/70601:PH_RS02885 ^@ http://purl.uniprot.org/uniprot/O58349 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/70601:PH_RS02975 ^@ http://purl.uniprot.org/uniprot/O58368 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/70601:PH_RS02160 ^@ http://purl.uniprot.org/uniprot/O58215 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Binds 2 Mg(2+) or Mn(2+) ions per subunit.|||Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.|||Cell membrane http://togogenome.org/gene/70601:PH_RS05395 ^@ http://purl.uniprot.org/uniprot/O58883 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/70601:PH_RS07990 ^@ http://purl.uniprot.org/uniprot/O59307 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/70601:PH_RS01570 ^@ http://purl.uniprot.org/uniprot/O58091 ^@ Similarity ^@ Belongs to the UPF0107 family. http://togogenome.org/gene/70601:PH_RS04030 ^@ http://purl.uniprot.org/uniprot/O58587 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/70601:PH_RS07845 ^@ http://purl.uniprot.org/uniprot/O59339 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/70601:PH_RS04755 ^@ http://purl.uniprot.org/uniprot/O58737 ^@ Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). http://togogenome.org/gene/70601:PH_RS06680 ^@ http://purl.uniprot.org/uniprot/O50122 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS04875 ^@ http://purl.uniprot.org/uniprot/O58760 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.|||Cell membrane|||Probably part of a binding-protein-dependent transport system PH1036/38/39. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/70601:PH_RS06435 ^@ http://purl.uniprot.org/uniprot/O59082 ^@ Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. http://togogenome.org/gene/70601:PH_RS04765 ^@ http://purl.uniprot.org/uniprot/O58739 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS04510 ^@ http://purl.uniprot.org/uniprot/O58665 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/70601:PH_RS06520 ^@ http://purl.uniprot.org/uniprot/O50083 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Homotetramer.|||Inhibited by D-4-phosphoerythronic acid.|||Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. http://togogenome.org/gene/70601:PH_RS08395 ^@ http://purl.uniprot.org/uniprot/O59420 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS09355 ^@ http://purl.uniprot.org/uniprot/O57724 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/70601:PH_RS09315 ^@ http://purl.uniprot.org/uniprot/O57734 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Editing domain AlaX-L subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Functions in trans to edit the amino acid moiety from mischarged charged tRNA(Ala). http://togogenome.org/gene/70601:PH_RS07650 ^@ http://purl.uniprot.org/uniprot/O59284 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).|||Homodimer.|||The protomer folds into three distinct domains: an N-terminal nucleotide binding domain, a central helical domain involved in dimerization and a C-terminal substrate binding domain. http://togogenome.org/gene/70601:PH_RS07575 ^@ http://purl.uniprot.org/uniprot/O59248 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 5 protein subunits. Forms a heterodimeric subcomplex with Rnp1. Reconstituted enzyme missing individual protein subunits is suboptimally active, showing each subunit contributes to optimization of activity.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Binds RNase P RNA. http://togogenome.org/gene/70601:PH_RS06380 ^@ http://purl.uniprot.org/uniprot/O59070 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/70601:PH_RS05705 ^@ http://purl.uniprot.org/uniprot/O58968 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.|||Cell membrane|||Probably part of a binding-protein-dependent transport system PH1214/15/16. Probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/70601:PH_RS03615 ^@ http://purl.uniprot.org/uniprot/O58489 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS06905 ^@ http://purl.uniprot.org/uniprot/O59132 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/70601:PH_RS00605 ^@ http://purl.uniprot.org/uniprot/O57871 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS02990 ^@ http://purl.uniprot.org/uniprot/O58370 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS06710 ^@ http://purl.uniprot.org/uniprot/O50129 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate (By similarity). Has phosphatase activity towards p-nitrophenylphosphate (in vitro).|||Homodimer. http://togogenome.org/gene/70601:PH_RS09375 ^@ http://purl.uniprot.org/uniprot/O57719 ^@ Domain|||Function ^@ Part of a potassium transport system.|||The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity). http://togogenome.org/gene/70601:PH_RS08080 ^@ http://purl.uniprot.org/uniprot/O59403 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BMP lipoprotein family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS02445 ^@ http://purl.uniprot.org/uniprot/O73977 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/70601:PH_RS07135 ^@ http://purl.uniprot.org/uniprot/O59180 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family.|||Homotrimer. Interacts with PH1510 and is cleaved by PH1510.|||Membrane http://togogenome.org/gene/70601:PH_RS08635 ^@ http://purl.uniprot.org/uniprot/O59494 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/70601:PH_RS05425 ^@ http://purl.uniprot.org/uniprot/O58878 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). http://togogenome.org/gene/70601:PH_RS05775 ^@ http://purl.uniprot.org/uniprot/O58954 ^@ Domain|||Function|||Similarity ^@ Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.|||Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).|||DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates. http://togogenome.org/gene/70601:PH_RS09340 ^@ http://purl.uniprot.org/uniprot/O57728 ^@ Function|||Miscellaneous|||PTM|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.|||The intein interrupts the ATP-binding site.|||This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation. http://togogenome.org/gene/70601:PH_RS07790 ^@ http://purl.uniprot.org/uniprot/O59351 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/70601:PH_RS06980 ^@ http://purl.uniprot.org/uniprot/O59148 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/70601:PH_RS04680 ^@ http://purl.uniprot.org/uniprot/O58720 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CutA family.|||Binds 1 copper ion in the interface between two trimers.|||Cytoplasm|||Homotrimer. The binding of the copper ion probably leads to oligomerization.|||Involved in resistance toward heavy metals. http://togogenome.org/gene/70601:PH_RS08985 ^@ http://purl.uniprot.org/uniprot/O74106 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS08315 ^@ http://purl.uniprot.org/uniprot/O59433 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/70601:PH_RS04655 ^@ http://purl.uniprot.org/uniprot/O58714 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LamB/PxpA family.|||Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.|||Forms a complex composed of PxpA, PxpB and PxpC. http://togogenome.org/gene/70601:PH_RS07880 ^@ http://purl.uniprot.org/uniprot/O59330 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/70601:PH_RS03420 ^@ http://purl.uniprot.org/uniprot/O58456 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.|||The diphthine intermediate is not stable in vitro and readily eliminates the trimethylamino group. It is not known whether the elimination reaction also occurs physiologically. http://togogenome.org/gene/70601:PH_RS05225 ^@ http://purl.uniprot.org/uniprot/O58844 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/70601:PH_RS07950 ^@ http://purl.uniprot.org/uniprot/O59314 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/70601:PH_RS05455 ^@ http://purl.uniprot.org/uniprot/O58871 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/70601:PH_RS03195 ^@ http://purl.uniprot.org/uniprot/O58415 ^@ Cofactor|||Subunit ^@ Binds 2 [4Fe-4S] clusters.|||Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/70601:PH_RS06260 ^@ http://purl.uniprot.org/uniprot/O59045 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0252 family.|||Membrane http://togogenome.org/gene/70601:PH_RS08610 ^@ http://purl.uniprot.org/uniprot/O59490 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 'phage' integrase family. XerA subfamily.|||Cytoplasm|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/70601:PH_RS06815 ^@ http://purl.uniprot.org/uniprot/O59114 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/70601:PH_RS00525 ^@ http://purl.uniprot.org/uniprot/O57853 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/70601:PH_RS03985 ^@ http://purl.uniprot.org/uniprot/O58577 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/70601:PH_RS00575 ^@ http://purl.uniprot.org/uniprot/O57865 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer. http://togogenome.org/gene/70601:PH_RS07680 ^@ http://purl.uniprot.org/uniprot/O59291 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS00485 ^@ http://purl.uniprot.org/uniprot/O74081 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.|||Homodimer. http://togogenome.org/gene/70601:PH_RS05640 ^@ http://purl.uniprot.org/uniprot/O58893 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/70601:PH_RS03170 ^@ http://purl.uniprot.org/uniprot/O58410 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/70601:PH_RS03180 ^@ http://purl.uniprot.org/uniprot/O58412 ^@ Cofactor|||Subunit ^@ Binds 2 [4Fe-4S] clusters.|||Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/70601:PH_RS06000 ^@ http://purl.uniprot.org/uniprot/O59029 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/70601:PH_RS02295 ^@ http://purl.uniprot.org/uniprot/O58226 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/70601:PH_RS09020 ^@ http://purl.uniprot.org/uniprot/O59571 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/70601:PH_RS05255 ^@ http://purl.uniprot.org/uniprot/O58851 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/70601:PH_RS06725 ^@ http://purl.uniprot.org/uniprot/O50131 ^@ Domain|||Function|||Similarity|||Subunit ^@ A 'Glu switch' mechanism prevents L-ornithine from binding in an orientation that would lead to transamination of the alpha-amino group (PubMed:35337912). The side-chain of Glu-236 forms a salt bridge with that of Arg-419, closing the 'Glu switch' and thus preventing unsuitable L-ornithine binding (PubMed:35337912).|||Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes the conversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate (PubMed:35337912). L-ornithine is the best substrate, but the enzyme also shows good activity toward L-lysine, and low activity toward D-ornithine, D-lysine, 5-aminovalerate, 6-aminohexanoate and GABA (PubMed:35337912). The enzyme activity is specific for 2-oxoglutarate (PubMed:35337912).|||Homotetramer; dimer of dimers. http://togogenome.org/gene/70601:PH_RS00545 ^@ http://purl.uniprot.org/uniprot/O57857 ^@ Function|||Similarity ^@ Belongs to the FAU-1 family.|||Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. http://togogenome.org/gene/70601:PH_RS03575 ^@ http://purl.uniprot.org/uniprot/O58496 ^@ Function|||Subunit ^@ Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/70601:PH_RS09175 ^@ http://purl.uniprot.org/uniprot/O59601 ^@ Similarity ^@ Belongs to the HPS/KGPDC family. HPS subfamily.|||Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/70601:PH_RS03190 ^@ http://purl.uniprot.org/uniprot/O58414 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/70601:PH_RS00255 ^@ http://purl.uniprot.org/uniprot/O57809 ^@ Similarity ^@ Belongs to the ACC deaminase/D-cysteine desulfhydrase family. http://togogenome.org/gene/70601:PH_RS03515 ^@ http://purl.uniprot.org/uniprot/O58510 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/70601:PH_RS06235 ^@ http://purl.uniprot.org/uniprot/P58503 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/70601:PH_RS03280 ^@ http://purl.uniprot.org/uniprot/O58428 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/70601:PH_RS08305 ^@ http://purl.uniprot.org/uniprot/O59437 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS07425 ^@ http://purl.uniprot.org/uniprot/O59279 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/70601:PH_RS08885 ^@ http://purl.uniprot.org/uniprot/O59536 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/70601:PH_RS04015 ^@ http://purl.uniprot.org/uniprot/O58584 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/70601:PH_RS07250 ^@ http://purl.uniprot.org/uniprot/O59205 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.|||Belongs to the archease family. http://togogenome.org/gene/70601:PH_RS00620 ^@ http://purl.uniprot.org/uniprot/O57875 ^@ Similarity ^@ Belongs to the archaeosine synthase type 1 family. http://togogenome.org/gene/70601:PH_RS01030 ^@ http://purl.uniprot.org/uniprot/O57966 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/70601:PH_RS06495 ^@ http://purl.uniprot.org/uniprot/O59094 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS04500 ^@ http://purl.uniprot.org/uniprot/O58667 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/70601:PH_RS00905 ^@ http://purl.uniprot.org/uniprot/O57939 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/70601:PH_RS07685 ^@ http://purl.uniprot.org/uniprot/O59292 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/70601:PH_RS04210 ^@ http://purl.uniprot.org/uniprot/O58642 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/70601:PH_RS09280 ^@ http://purl.uniprot.org/uniprot/O59614 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS02030 ^@ http://purl.uniprot.org/uniprot/O58166 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/70601:PH_RS07465 ^@ http://purl.uniprot.org/uniprot/O59268 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/70601:PH_RS08110 ^@ http://purl.uniprot.org/uniprot/O59396 ^@ Similarity ^@ Belongs to the RimK family. LysX subfamily. http://togogenome.org/gene/70601:PH_RS06915 ^@ http://purl.uniprot.org/uniprot/O59134 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation. http://togogenome.org/gene/70601:PH_RS08400 ^@ http://purl.uniprot.org/uniprot/O59418 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/70601:PH_RS00125 ^@ http://purl.uniprot.org/uniprot/O57757 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS01460 ^@ http://purl.uniprot.org/uniprot/O58061 ^@ Cofactor|||Similarity ^@ Belongs to the GARS family.|||Binds 2 magnesium or manganese ions per subunit. http://togogenome.org/gene/70601:PH_RS06500 ^@ http://purl.uniprot.org/uniprot/O59096 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/70601:PH_RS02085 ^@ http://purl.uniprot.org/uniprot/O58185 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of initiation factor 2-bound GDP for GTP.|||Complex of two different subunits. http://togogenome.org/gene/70601:PH_RS01365 ^@ http://purl.uniprot.org/uniprot/P84142 ^@ Similarity|||Subunit ^@ Belongs to the acylphosphatase family.|||Monomer. http://togogenome.org/gene/70601:PH_RS04745 ^@ http://purl.uniprot.org/uniprot/O58734 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/70601:PH_RS08965 ^@ http://purl.uniprot.org/uniprot/O59521 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).|||Cytoplasm http://togogenome.org/gene/70601:PH_RS00020 ^@ http://purl.uniprot.org/uniprot/P58199 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/70601:PH_RS04380 ^@ http://purl.uniprot.org/uniprot/O58689 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Cytoplasm|||Transfers a mannosyl group from GDP-mannose to phosphoglycerate to form mannosyl-3-phosphoglycerate (MPG). The enzyme is absolutely specific for GDP-mannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. http://togogenome.org/gene/70601:PH_RS08565 ^@ http://purl.uniprot.org/uniprot/O59482 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS00040 ^@ http://purl.uniprot.org/uniprot/O57774 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/70601:PH_RS01100 ^@ http://purl.uniprot.org/uniprot/O57980 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS05165 ^@ http://purl.uniprot.org/uniprot/O58832 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the DPH1/DPH2 family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).|||Homodimer.|||In contrast to eukaryotes that require four gene products (DPH1, DPH2, DPH3 and DPH4) to catalyze the first step of diphthamide biosynthesis, no other protein than Dph2 is required in P.horikoshii.|||Unlike the enzymes in the radical SAM superfamily, Dph2 does not form the canonical 5'-deoxyadenosyl radical. Instead, it breaks the C(gamma)-S bond of SAM and generates a 3-amino-3-carboxypropyl radical intermediate. Thus, the P.horikoshii Dph2 represents a previously unknown, SAM-dependent, [4Fe-4S]-containing enzyme that catalyzes unprecedented chemistry. Moreover, the chemistry requires only one [4Fe-4S] cluster to be present in the Dph2 dimer, although each monomer can bind a [4Fe-4S] cluster. http://togogenome.org/gene/70601:PH_RS00095 ^@ http://purl.uniprot.org/uniprot/O57764 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 2 family.|||Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/70601:PH_RS02090 ^@ http://purl.uniprot.org/uniprot/O58183 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.|||Has ATPase and non-specific DNA-binding activities. http://togogenome.org/gene/70601:PH_RS07700 ^@ http://purl.uniprot.org/uniprot/O59296 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/70601:PH_RS02100 ^@ http://purl.uniprot.org/uniprot/O58180 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/70601:PH_RS05325 ^@ http://purl.uniprot.org/uniprot/O58864 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in tRNA. http://togogenome.org/gene/70601:PH_RS00130 ^@ http://purl.uniprot.org/uniprot/O57756 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/70601:PH_RS00270 ^@ http://purl.uniprot.org/uniprot/O57805 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/70601:PH_RS02720 ^@ http://purl.uniprot.org/uniprot/O58336 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/70601:PH_RS01015 ^@ http://purl.uniprot.org/uniprot/O57963 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/70601:PH_RS02795 ^@ http://purl.uniprot.org/uniprot/O58323 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/70601:PH_RS07740 ^@ http://purl.uniprot.org/uniprot/O59303 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/70601:PH_RS07305 ^@ http://purl.uniprot.org/uniprot/O59227 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/70601:PH_RS03425 ^@ http://purl.uniprot.org/uniprot/O58457 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Homododecamer.|||Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. http://togogenome.org/gene/70601:PH_RS02460 ^@ http://purl.uniprot.org/uniprot/P59473 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/70601:PH_RS02000 ^@ http://purl.uniprot.org/uniprot/O58158 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS03070 ^@ http://purl.uniprot.org/uniprot/O58389 ^@ Activity Regulation|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Binds 2 Zn(2+) ions per subunit. Contains one structural ion and one catalytic ion that seems to be less tightly bound at the site (PubMed:16233775). Zn(2+) can be replaced by Mn(2+) or Co(2+) to some extent (PubMed:15902509).|||Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate (PubMed:16233775, PubMed:15902509). Is much less efficient when using NADP(+) instead of NAD(+) (PubMed:16233775). To a lesser extent, also catalyzes the oxidation of L-serine and DL-threo-3-phenylserine, but not that of L-allo-threonine, D-threonine and D-allo-threonine and many other L-amino acids (PubMed:15902509).|||Cytoplasm|||Homodimer (PubMed:16233775). Homotetramer; dimer of dimers (PubMed:17188300) (PubMed:15902509).|||Is totally inhibited by EDTA in vitro.|||The enzyme shows pro-R stereospecificity for hydrogen transfer at the C4 position of the nicotinamide moiety of NADH. http://togogenome.org/gene/70601:PH_RS04005 ^@ http://purl.uniprot.org/uniprot/O58581 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/70601:PH_RS07770 ^@ http://purl.uniprot.org/uniprot/O59357 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/70601:PH_RS08595 ^@ http://purl.uniprot.org/uniprot/O59487 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/70601:PH_RS08010 ^@ http://purl.uniprot.org/uniprot/O59362 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Binds two Mg(2+) per subunit.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/70601:PH_RS07720 ^@ http://purl.uniprot.org/uniprot/O59299 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/70601:PH_RS06970 ^@ http://purl.uniprot.org/uniprot/O59146 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/70601:PH_RS03085 ^@ http://purl.uniprot.org/uniprot/O58393 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). http://togogenome.org/gene/70601:PH_RS00915 ^@ http://purl.uniprot.org/uniprot/O57942 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS04780 ^@ http://purl.uniprot.org/uniprot/O58742 ^@ Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN. http://togogenome.org/gene/70601:PH_RS08945 ^@ http://purl.uniprot.org/uniprot/P60463 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC61-beta family.|||Cell membrane|||Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).|||Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity). http://togogenome.org/gene/70601:PH_RS06240 ^@ http://purl.uniprot.org/uniprot/O59049 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/70601:PH_RS03175 ^@ http://purl.uniprot.org/uniprot/O58411 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/70601:PH_RS08760 ^@ http://purl.uniprot.org/uniprot/O74102 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/70601:PH_RS06540 ^@ http://purl.uniprot.org/uniprot/O50087 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/70601:PH_RS07935 ^@ http://purl.uniprot.org/uniprot/O59318 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/70601:PH_RS06795 ^@ http://purl.uniprot.org/uniprot/O59109 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/70601:PH_RS05040 ^@ http://purl.uniprot.org/uniprot/O58801 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Homotetramer.|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates (GTP,UTP) as well as inorganic polyphosphate (poly(P)) as a source of phosphorus. NAD is the preferred substrate for the kinase, but NADH can also be used as phosphoryl acceptor. http://togogenome.org/gene/70601:PH_RS08235 ^@ http://purl.uniprot.org/uniprot/O59371 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family.