http://togogenome.org/gene/866895:HBHAL_RS20090 ^@ http://purl.uniprot.org/uniprot/I0JTL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ParB family.|||Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage.|||nucleoid http://togogenome.org/gene/866895:HBHAL_RS08905 ^@ http://purl.uniprot.org/uniprot/I0JLY8 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS00600 ^@ http://purl.uniprot.org/uniprot/I0JH65 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/866895:HBHAL_RS13040 ^@ http://purl.uniprot.org/uniprot/I0JPE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A24 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12690 ^@ http://purl.uniprot.org/uniprot/I0JP75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00170 ^@ http://purl.uniprot.org/uniprot/I0JGZ9 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/866895:HBHAL_RS12035 ^@ http://purl.uniprot.org/uniprot/I0JNU5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS13510 ^@ http://purl.uniprot.org/uniprot/I0JPN7 ^@ Similarity ^@ Belongs to the pyruvate kinase family.|||In the C-terminal section; belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/866895:HBHAL_RS18445 ^@ http://purl.uniprot.org/uniprot/I0JSM8 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/866895:HBHAL_RS17475 ^@ http://purl.uniprot.org/uniprot/I0JS28 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/866895:HBHAL_RS07010 ^@ http://purl.uniprot.org/uniprot/I0JKU1 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/866895:HBHAL_RS15770 ^@ http://purl.uniprot.org/uniprot/I0JR03 ^@ Similarity ^@ Belongs to the CapA family. http://togogenome.org/gene/866895:HBHAL_RS14645 ^@ http://purl.uniprot.org/uniprot/I0JQC1 ^@ Similarity ^@ Belongs to the nitroreductase family. http://togogenome.org/gene/866895:HBHAL_RS04030 ^@ http://purl.uniprot.org/uniprot/I0JJ52 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/866895:HBHAL_RS06065 ^@ http://purl.uniprot.org/uniprot/I0JK91 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/866895:HBHAL_RS08580 ^@ http://purl.uniprot.org/uniprot/I0JLR8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS05445 ^@ http://purl.uniprot.org/uniprot/I0JJX2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueG family.|||Binds 2 [4Fe-4S] clusters per monomer.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS15390 ^@ http://purl.uniprot.org/uniprot/I0JQS1 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/866895:HBHAL_RS00475 ^@ http://purl.uniprot.org/uniprot/I0JH55 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/866895:HBHAL_RS09150 ^@ http://purl.uniprot.org/uniprot/I0JM42 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/866895:HBHAL_RS01555 ^@ http://purl.uniprot.org/uniprot/I0JHP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS01235 ^@ http://purl.uniprot.org/uniprot/I0JHH8 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/866895:HBHAL_RS10375 ^@ http://purl.uniprot.org/uniprot/I0JMU7 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/866895:HBHAL_RS09325 ^@ http://purl.uniprot.org/uniprot/I0JM79 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.|||Cytoplasm|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits. http://togogenome.org/gene/866895:HBHAL_RS13350 ^@ http://purl.uniprot.org/uniprot/I0JPK3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/866895:HBHAL_RS16060 ^@ http://purl.uniprot.org/uniprot/I0JR64 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/866895:HBHAL_RS01865 ^@ http://purl.uniprot.org/uniprot/I0JHW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09015 ^@ http://purl.uniprot.org/uniprot/I0JM13 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Cell membrane|||Membrane|||Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). http://togogenome.org/gene/866895:HBHAL_RS05890 ^@ http://purl.uniprot.org/uniprot/I0JK57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09865 ^@ http://purl.uniprot.org/uniprot/I0JMJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/866895:HBHAL_RS09860 ^@ http://purl.uniprot.org/uniprot/I0JMJ0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein uS19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein uS19. http://togogenome.org/gene/866895:HBHAL_RS10255 ^@ http://purl.uniprot.org/uniprot/I0JMS2 ^@ Similarity ^@ Belongs to the FtsK/SpoIIIE/SftA family. http://togogenome.org/gene/866895:HBHAL_RS20165 ^@ http://purl.uniprot.org/uniprot/I0JTN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/866895:HBHAL_RS14625 ^@ http://purl.uniprot.org/uniprot/I0JQB7 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10670 ^@ http://purl.uniprot.org/uniprot/I0JN09 ^@ Similarity ^@ Belongs to the CvfB family. http://togogenome.org/gene/866895:HBHAL_RS15310 ^@ http://purl.uniprot.org/uniprot/I0JQQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gas vesicle GvpF/GvpL family.|||Gas vesicle|||Vesicle http://togogenome.org/gene/866895:HBHAL_RS11375 ^@ http://purl.uniprot.org/uniprot/I0JNF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS17180 ^@ http://purl.uniprot.org/uniprot/I0JRW8 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/866895:HBHAL_RS10100 ^@ http://purl.uniprot.org/uniprot/I0JMP1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/866895:HBHAL_RS02000 ^@ http://purl.uniprot.org/uniprot/I0JHZ2 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/866895:HBHAL_RS10050 ^@ http://purl.uniprot.org/uniprot/I0JMM8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type III secretion exporter family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/866895:HBHAL_RS01025 ^@ http://purl.uniprot.org/uniprot/I0JHD7 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/866895:HBHAL_RS00605 ^@ http://purl.uniprot.org/uniprot/I0JH66 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/866895:HBHAL_RS13405 ^@ http://purl.uniprot.org/uniprot/I0JPL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS01040 ^@ http://purl.uniprot.org/uniprot/I0JHE1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the adenylate cyclase family. DacA/CdaA subfamily.|||Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably a homodimer. http://togogenome.org/gene/866895:HBHAL_RS01915 ^@ http://purl.uniprot.org/uniprot/I0JHX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS20055 ^@ http://purl.uniprot.org/uniprot/I0JTK8 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/866895:HBHAL_RS00285 ^@ http://purl.uniprot.org/uniprot/I0JH18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS19705 ^@ http://purl.uniprot.org/uniprot/I0JTD9 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/866895:HBHAL_RS13050 ^@ http://purl.uniprot.org/uniprot/I0JPE7 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/866895:HBHAL_RS14600 ^@ http://purl.uniprot.org/uniprot/I0JQB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS01610 ^@ http://purl.uniprot.org/uniprot/I0JHR4 ^@ Similarity ^@ Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family. http://togogenome.org/gene/866895:HBHAL_RS16260 ^@ http://purl.uniprot.org/uniprot/I0JRA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0053 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05000 ^@ http://purl.uniprot.org/uniprot/I0JJQ2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS00755 ^@ http://purl.uniprot.org/uniprot/I0JH97 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/866895:HBHAL_RS00720 ^@ http://purl.uniprot.org/uniprot/I0JH90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS11810 ^@ http://purl.uniprot.org/uniprot/I0JNP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS02640 ^@ http://purl.uniprot.org/uniprot/I0JIA7 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/866895:HBHAL_RS01225 ^@ http://purl.uniprot.org/uniprot/I0JHH6 ^@ Function|||Similarity ^@ Belongs to the uve1/UvsE family.|||Component in a DNA repair pathway. Removal of UV LIGHT damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion.|||Component in a DNA repair pathway. Removal of UV-light damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion. http://togogenome.org/gene/866895:HBHAL_RS19540 ^@ http://purl.uniprot.org/uniprot/I0JTA3 ^@ Similarity ^@ Belongs to the MQO family. http://togogenome.org/gene/866895:HBHAL_RS00740 ^@ http://purl.uniprot.org/uniprot/I0JH94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS13230 ^@ http://purl.uniprot.org/uniprot/I0JPH7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/866895:HBHAL_RS10845 ^@ http://purl.uniprot.org/uniprot/I0JN45 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MobA family.|||Cytoplasm|||The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.|||Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. http://togogenome.org/gene/866895:HBHAL_RS16715 ^@ http://purl.uniprot.org/uniprot/I0JRL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/866895:HBHAL_RS20175 ^@ http://purl.uniprot.org/uniprot/I0JTN3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpB RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpA.|||Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS04995 ^@ http://purl.uniprot.org/uniprot/I0JJQ1 ^@ Similarity ^@ Belongs to the PTPS family. QueD subfamily. http://togogenome.org/gene/866895:HBHAL_RS04180 ^@ http://purl.uniprot.org/uniprot/I0JJ83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS00790 ^@ http://purl.uniprot.org/uniprot/I0JHA4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS05090 ^@ http://purl.uniprot.org/uniprot/I0JJR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06825 ^@ http://purl.uniprot.org/uniprot/I0JKQ5 ^@ Similarity ^@ Belongs to the 4-oxalocrotonate tautomerase family. http://togogenome.org/gene/866895:HBHAL_RS17385 ^@ http://purl.uniprot.org/uniprot/I0JS09 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS00750 ^@ http://purl.uniprot.org/uniprot/I0JH96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/866895:HBHAL_RS04735 ^@ http://purl.uniprot.org/uniprot/I0JJJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS15325 ^@ http://purl.uniprot.org/uniprot/I0JQQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gas vesicle GvpA family.|||Gas vesicle shell|||Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.|||The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle. http://togogenome.org/gene/866895:HBHAL_RS19030 ^@ http://purl.uniprot.org/uniprot/I0JT01 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS07790 ^@ http://purl.uniprot.org/uniprot/I0JL95 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS07765 ^@ http://purl.uniprot.org/uniprot/I0JQV5 ^@ Similarity ^@ Belongs to the transposase 11 family. http://togogenome.org/gene/866895:HBHAL_RS08665 ^@ http://purl.uniprot.org/uniprot/I0JLT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11555 ^@ http://purl.uniprot.org/uniprot/I0JNJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13955 ^@ http://purl.uniprot.org/uniprot/I0JPX9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/866895:HBHAL_RS15295 ^@ http://purl.uniprot.org/uniprot/I0JQQ2 ^@ Similarity ^@ Belongs to the gas vesicle GvpA family. http://togogenome.org/gene/866895:HBHAL_RS10265 ^@ http://purl.uniprot.org/uniprot/I0JMS4 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/866895:HBHAL_RS05545 ^@ http://purl.uniprot.org/uniprot/I0JJZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS13875 ^@ http://purl.uniprot.org/uniprot/I0JPW2 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/866895:HBHAL_RS00460 ^@ http://purl.uniprot.org/uniprot/I0JH52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS00595 ^@ http://purl.uniprot.org/uniprot/I0JH64 ^@ Activity Regulation|||Function|||Similarity ^@ Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.|||Belongs to the ATP:guanido phosphotransferase family.|||Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. http://togogenome.org/gene/866895:HBHAL_RS12045 ^@ http://purl.uniprot.org/uniprot/I0JNU8 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/866895:HBHAL_RS01050 ^@ http://purl.uniprot.org/uniprot/I0JHE3 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/866895:HBHAL_RS10190 ^@ http://purl.uniprot.org/uniprot/I0JMQ8 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/866895:HBHAL_RS16560 ^@ http://purl.uniprot.org/uniprot/I0JRH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS19510 ^@ http://purl.uniprot.org/uniprot/I0JT97 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/866895:HBHAL_RS00375 ^@ http://purl.uniprot.org/uniprot/I0JH36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/866895:HBHAL_RS10570 ^@ http://purl.uniprot.org/uniprot/I0JMY8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS13135 ^@ http://purl.uniprot.org/uniprot/I0JPG4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/866895:HBHAL_RS19590 ^@ http://purl.uniprot.org/uniprot/I0JTB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS04245 ^@ http://purl.uniprot.org/uniprot/I0JJ97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00745 ^@ http://purl.uniprot.org/uniprot/I0JH95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/866895:HBHAL_RS15010 ^@ http://purl.uniprot.org/uniprot/I0JQJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/866895:HBHAL_RS05610 ^@ http://purl.uniprot.org/uniprot/I0JK02 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS11100 ^@ http://purl.uniprot.org/uniprot/I0JNA0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS12925 ^@ http://purl.uniprot.org/uniprot/I0JPC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS00895 ^@ http://purl.uniprot.org/uniprot/I0JHC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the energy-coupling factor EcfT family.|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).|||Membrane|||Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. http://togogenome.org/gene/866895:HBHAL_RS13330 ^@ http://purl.uniprot.org/uniprot/I0JPJ8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/866895:HBHAL_RS00025 ^@ http://purl.uniprot.org/uniprot/I0JGX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/866895:HBHAL_RS02500 ^@ http://purl.uniprot.org/uniprot/I0JI76 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13975 ^@ http://purl.uniprot.org/uniprot/I0JPY3 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.|||Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). http://togogenome.org/gene/866895:HBHAL_RS05950 ^@ http://purl.uniprot.org/uniprot/Q00213 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the alpha/beta-type SASP family.|||SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.|||SASP are degraded in the first minutes of spore germination and provide amino acids for both new protein synthesis and metabolism. http://togogenome.org/gene/866895:HBHAL_RS09330 ^@ http://purl.uniprot.org/uniprot/I0JM80 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS06800 ^@ http://purl.uniprot.org/uniprot/I0JKQ0 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS03610 ^@ http://purl.uniprot.org/uniprot/I0JIW3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12390 ^@ http://purl.uniprot.org/uniprot/I0JP12 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08730 ^@ http://purl.uniprot.org/uniprot/I0JLV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS03505 ^@ http://purl.uniprot.org/uniprot/I0JIU1 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/866895:HBHAL_RS07855 ^@ http://purl.uniprot.org/uniprot/I0JLB0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS19945 ^@ http://purl.uniprot.org/uniprot/I0JTI7 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/866895:HBHAL_RS00610 ^@ http://purl.uniprot.org/uniprot/I0JH67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DisA family.|||Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.|||Homooctamer.|||Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation. http://togogenome.org/gene/866895:HBHAL_RS03025 ^@ http://purl.uniprot.org/uniprot/I0JII7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0316 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05165 ^@ http://purl.uniprot.org/uniprot/I0JJT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/866895:HBHAL_RS04260 ^@ http://purl.uniprot.org/uniprot/I0JJA0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07285 ^@ http://purl.uniprot.org/uniprot/I0JL01 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/866895:HBHAL_RS09110 ^@ http://purl.uniprot.org/uniprot/I0JM33 ^@ Caution|||Similarity ^@ Belongs to the NTE family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS06335 ^@ http://purl.uniprot.org/uniprot/I0JKE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.|||Catalyzes the interconversion of ornithine to glutamate semialdehyde.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS00580 ^@ http://purl.uniprot.org/uniprot/I0JH61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09030 ^@ http://purl.uniprot.org/uniprot/I0JM16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase bacterial subunit 4 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS20445 ^@ http://purl.uniprot.org/uniprot/I0JQX9 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/866895:HBHAL_RS10560 ^@ http://purl.uniprot.org/uniprot/I0JMY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.|||Cell membrane|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/866895:HBHAL_RS04020 ^@ http://purl.uniprot.org/uniprot/I0JJ50 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/866895:HBHAL_RS13410 ^@ http://purl.uniprot.org/uniprot/I0JPL6 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS20100 ^@ http://purl.uniprot.org/uniprot/I0JTL7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS02775 ^@ http://purl.uniprot.org/uniprot/I0JID7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS09520 ^@ http://purl.uniprot.org/uniprot/I0JMB9 ^@ Function|||Similarity ^@ Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. http://togogenome.org/gene/866895:HBHAL_RS12870 ^@ http://purl.uniprot.org/uniprot/I0JPB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS10715 ^@ http://purl.uniprot.org/uniprot/I0JN19 ^@ Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/866895:HBHAL_RS01360 ^@ http://purl.uniprot.org/uniprot/I0JHK2 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/866895:HBHAL_RS18990 ^@ http://purl.uniprot.org/uniprot/I0JSZ3 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/866895:HBHAL_RS05205 ^@ http://purl.uniprot.org/uniprot/I0JJU1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS01510 ^@ http://purl.uniprot.org/uniprot/I0JHP1 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/866895:HBHAL_RS01085 ^@ http://purl.uniprot.org/uniprot/I0JHE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10055 ^@ http://purl.uniprot.org/uniprot/I0JMM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.|||Cell membrane|||Membrane|||Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. http://togogenome.org/gene/866895:HBHAL_RS14720 ^@ http://purl.uniprot.org/uniprot/I0JQD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gluconeogenesis factor family.|||Cytoplasm|||Required for morphogenesis under gluconeogenic growth conditions. http://togogenome.org/gene/866895:HBHAL_RS01285 ^@ http://purl.uniprot.org/uniprot/I0JHI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18525 ^@ http://purl.uniprot.org/uniprot/I0JSP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M4 family.|||Extracellular zinc metalloprotease.|||Secreted http://togogenome.org/gene/866895:HBHAL_RS03870 ^@ http://purl.uniprot.org/uniprot/I0JJ19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS14660 ^@ http://purl.uniprot.org/uniprot/I0JQC4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Essential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS12685 ^@ http://purl.uniprot.org/uniprot/I0JP74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16420 ^@ http://purl.uniprot.org/uniprot/I0JRE7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16895 ^@ http://purl.uniprot.org/uniprot/I0JRQ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16630 ^@ http://purl.uniprot.org/uniprot/I0JRJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS08475 ^@ http://purl.uniprot.org/uniprot/I0JLP4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/866895:HBHAL_RS12250 ^@ http://purl.uniprot.org/uniprot/I0JNY8 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/866895:HBHAL_RS01530 ^@ http://purl.uniprot.org/uniprot/I0JHP5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS06490 ^@ http://purl.uniprot.org/uniprot/I0JKI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS11030 ^@ http://purl.uniprot.org/uniprot/I0JN86 ^@ Function|||Similarity ^@ Belongs to the methylglyoxal synthase family.|||Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. http://togogenome.org/gene/866895:HBHAL_RS13495 ^@ http://purl.uniprot.org/uniprot/I0JPN4 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/866895:HBHAL_RS08170 ^@ http://purl.uniprot.org/uniprot/I0JLH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS04190 ^@ http://purl.uniprot.org/uniprot/I0JJ85 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/866895:HBHAL_RS09195 ^@ http://purl.uniprot.org/uniprot/I0JM51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/866895:HBHAL_RS05975 ^@ http://purl.uniprot.org/uniprot/I0JK75 ^@ Similarity ^@ Belongs to the UPF0754 family. http://togogenome.org/gene/866895:HBHAL_RS18075 ^@ http://purl.uniprot.org/uniprot/I0JSE8 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/866895:HBHAL_RS19520 ^@ http://purl.uniprot.org/uniprot/I0JT99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS00855 ^@ http://purl.uniprot.org/uniprot/I0JHB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/866895:HBHAL_RS04470 ^@ http://purl.uniprot.org/uniprot/I0JJE5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS06230 ^@ http://purl.uniprot.org/uniprot/I0JKC9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the helicase family. AddB/RexB type 1 subfamily.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of AddA and AddB.|||The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity. http://togogenome.org/gene/866895:HBHAL_RS19845 ^@ http://purl.uniprot.org/uniprot/I0JTG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbsD / FucU family. RbsD subfamily.|||Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.|||Cytoplasm|||Homodecamer. http://togogenome.org/gene/866895:HBHAL_RS15285 ^@ http://purl.uniprot.org/uniprot/I0JQQ0 ^@ Similarity ^@ Belongs to the gas vesicle GvpA family. http://togogenome.org/gene/866895:HBHAL_RS16695 ^@ http://purl.uniprot.org/uniprot/I0JRK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11140 ^@ http://purl.uniprot.org/uniprot/I0JNA8 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/866895:HBHAL_RS12530 ^@ http://purl.uniprot.org/uniprot/I0JP42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12495 ^@ http://purl.uniprot.org/uniprot/I0JP35 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Membrane|||Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents. http://togogenome.org/gene/866895:HBHAL_RS01310 ^@ http://purl.uniprot.org/uniprot/I0JHJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10235 ^@ http://purl.uniprot.org/uniprot/I0JMR7 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine. http://togogenome.org/gene/866895:HBHAL_RS01245 ^@ http://purl.uniprot.org/uniprot/I0JHI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09790 ^@ http://purl.uniprot.org/uniprot/I0JMH6 ^@ Function|||Similarity ^@ Belongs to the FapR family.|||Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism. http://togogenome.org/gene/866895:HBHAL_RS10325 ^@ http://purl.uniprot.org/uniprot/I0JMT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS10060 ^@ http://purl.uniprot.org/uniprot/I0JMN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Cell membrane|||Membrane|||Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum. http://togogenome.org/gene/866895:HBHAL_RS03560 ^@ http://purl.uniprot.org/uniprot/I0JIV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LTA synthase family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13395 ^@ http://purl.uniprot.org/uniprot/I0JPL3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/866895:HBHAL_RS13300 ^@ http://purl.uniprot.org/uniprot/I0JPJ2 ^@ Similarity ^@ Belongs to the ETF beta-subunit/FixA family. http://togogenome.org/gene/866895:HBHAL_RS18575 ^@ http://purl.uniprot.org/uniprot/I0JSQ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01630 ^@ http://purl.uniprot.org/uniprot/I0JHR8 ^@ Function|||Similarity ^@ Functions as a fatty acid monooxygenase.|||In the N-terminal section; belongs to the cytochrome P450 family. http://togogenome.org/gene/866895:HBHAL_RS02825 ^@ http://purl.uniprot.org/uniprot/I0JIE7 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/866895:HBHAL_RS09915 ^@ http://purl.uniprot.org/uniprot/I0JMK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/866895:HBHAL_RS14580 ^@ http://purl.uniprot.org/uniprot/I0JQA8 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subunit ^@ Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).|||Belongs to the FGGY kinase family.|||Homotetramer and homodimer (in equilibrium).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme. http://togogenome.org/gene/866895:HBHAL_RS04535 ^@ http://purl.uniprot.org/uniprot/I0JJF8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS14735 ^@ http://purl.uniprot.org/uniprot/I0JQD8 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS00195 ^@ http://purl.uniprot.org/uniprot/I0JH04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/866895:HBHAL_RS02040 ^@ http://purl.uniprot.org/uniprot/I0JI00 ^@ Function|||Similarity ^@ Belongs to the PemK/MazF family.|||Toxic component of a type II toxin-antitoxin (TA) system. http://togogenome.org/gene/866895:HBHAL_RS05980 ^@ http://purl.uniprot.org/uniprot/I0JK76 ^@ Similarity ^@ Belongs to the UPF0342 family. http://togogenome.org/gene/866895:HBHAL_RS00360 ^@ http://purl.uniprot.org/uniprot/I0JH33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/866895:HBHAL_RS03065 ^@ http://purl.uniprot.org/uniprot/I0JIJ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/866895:HBHAL_RS07640 ^@ http://purl.uniprot.org/uniprot/I0JL64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. http://togogenome.org/gene/866895:HBHAL_RS00710 ^@ http://purl.uniprot.org/uniprot/I0JH88 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/866895:HBHAL_RS09000 ^@ http://purl.uniprot.org/uniprot/I0JM09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS14365 ^@ http://purl.uniprot.org/uniprot/I0JQ66 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/866895:HBHAL_RS02685 ^@ http://purl.uniprot.org/uniprot/I0JIB6 ^@ Similarity ^@ Belongs to the transpeptidase family. http://togogenome.org/gene/866895:HBHAL_RS19970 ^@ http://purl.uniprot.org/uniprot/I0JTJ3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/866895:HBHAL_RS04265 ^@ http://purl.uniprot.org/uniprot/I0JJA1 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/866895:HBHAL_RS14745 ^@ http://purl.uniprot.org/uniprot/I0JQE0 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/866895:HBHAL_RS13475 ^@ http://purl.uniprot.org/uniprot/I0JPN0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS19685 ^@ http://purl.uniprot.org/uniprot/I0JTD5 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/866895:HBHAL_RS01750 ^@ http://purl.uniprot.org/uniprot/I0JHU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00095 ^@ http://purl.uniprot.org/uniprot/I0JGY5 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/866895:HBHAL_RS14305 ^@ http://purl.uniprot.org/uniprot/I0JQ53 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/866895:HBHAL_RS10835 ^@ http://purl.uniprot.org/uniprot/I0JN43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/866895:HBHAL_RS19820 ^@ http://purl.uniprot.org/uniprot/I0JTG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/866895:HBHAL_RS01550 ^@ http://purl.uniprot.org/uniprot/I0JHP7 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/866895:HBHAL_RS11490 ^@ http://purl.uniprot.org/uniprot/I0JNI0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS03020 ^@ http://purl.uniprot.org/uniprot/I0JII6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/866895:HBHAL_RS12740 ^@ http://purl.uniprot.org/uniprot/I0JP85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS13465 ^@ http://purl.uniprot.org/uniprot/I0JPM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.|||Single-chain monomer with multiple functions. http://togogenome.org/gene/866895:HBHAL_RS08135 ^@ http://purl.uniprot.org/uniprot/I0JLH2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family. IolA subfamily.|||Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS11960 ^@ http://purl.uniprot.org/uniprot/I0JNT1 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/866895:HBHAL_RS16825 ^@ http://purl.uniprot.org/uniprot/I0JRN7 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.|||Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. http://togogenome.org/gene/866895:HBHAL_RS00685 ^@ http://purl.uniprot.org/uniprot/I0JH83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/866895:HBHAL_RS09780 ^@ http://purl.uniprot.org/uniprot/I0JMH4 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/866895:HBHAL_RS17675 ^@ http://purl.uniprot.org/uniprot/I0JS71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS11890 ^@ http://purl.uniprot.org/uniprot/I0JNR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS17700 ^@ http://purl.uniprot.org/uniprot/I0JS76 ^@ Similarity ^@ Belongs to the ChdC family. Type 1 subfamily. http://togogenome.org/gene/866895:HBHAL_RS17105 ^@ http://purl.uniprot.org/uniprot/I0JRV3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 36 family. http://togogenome.org/gene/866895:HBHAL_RS00680 ^@ http://purl.uniprot.org/uniprot/I0JH82 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/866895:HBHAL_RS12855 ^@ http://purl.uniprot.org/uniprot/I0JPA8 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/866895:HBHAL_RS14530 ^@ http://purl.uniprot.org/uniprot/I0JQ98 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS01120 ^@ http://purl.uniprot.org/uniprot/I0JHF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS15110 ^@ http://purl.uniprot.org/uniprot/I0JQL6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS14460 ^@ http://purl.uniprot.org/uniprot/I0JQ83 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS15235 ^@ http://purl.uniprot.org/uniprot/I0JQP0 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/866895:HBHAL_RS13000 ^@ http://purl.uniprot.org/uniprot/I0JPD7 ^@ Function|||Similarity ^@ ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.|||Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/866895:HBHAL_RS05690 ^@ http://purl.uniprot.org/uniprot/I0JK18 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/866895:HBHAL_RS18170 ^@ http://purl.uniprot.org/uniprot/I0JSG8 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13705 ^@ http://purl.uniprot.org/uniprot/I0JPS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS03510 ^@ http://purl.uniprot.org/uniprot/I0JIU2 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/866895:HBHAL_RS14845 ^@ http://purl.uniprot.org/uniprot/I0JQF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS17600 ^@ http://purl.uniprot.org/uniprot/I0JS56 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS03635 ^@ http://purl.uniprot.org/uniprot/I0JIW8 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/866895:HBHAL_RS09920 ^@ http://purl.uniprot.org/uniprot/I0JMK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/866895:HBHAL_RS06500 ^@ http://purl.uniprot.org/uniprot/I0JKI5 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/866895:HBHAL_RS12695 ^@ http://purl.uniprot.org/uniprot/I0JP76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14715 ^@ http://purl.uniprot.org/uniprot/I0JQD4 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/866895:HBHAL_RS10350 ^@ http://purl.uniprot.org/uniprot/I0JMU2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.|||Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS12020 ^@ http://purl.uniprot.org/uniprot/I0JNU2 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/866895:HBHAL_RS15570 ^@ http://purl.uniprot.org/uniprot/I0JQW3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS02970 ^@ http://purl.uniprot.org/uniprot/I0JIH6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS06770 ^@ http://purl.uniprot.org/uniprot/I0JKP4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10040 ^@ http://purl.uniprot.org/uniprot/I0JMM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliQ/MopD/SpaQ family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/866895:HBHAL_RS08125 ^@ http://purl.uniprot.org/uniprot/I0JLH0 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/866895:HBHAL_RS09230 ^@ http://purl.uniprot.org/uniprot/I0JM58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase U4 family.|||Cell membrane|||Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.|||Self-associates. Interacts with SigE. Interacts with SpoIIR. http://togogenome.org/gene/866895:HBHAL_RS00465 ^@ http://purl.uniprot.org/uniprot/I0JH53 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/866895:HBHAL_RS13095 ^@ http://purl.uniprot.org/uniprot/I0JPF6 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/866895:HBHAL_RS15460 ^@ http://purl.uniprot.org/uniprot/I0JQT7 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/866895:HBHAL_RS12485 ^@ http://purl.uniprot.org/uniprot/I0JP31 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/866895:HBHAL_RS10985 ^@ http://purl.uniprot.org/uniprot/I0JN76 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS13400 ^@ http://purl.uniprot.org/uniprot/I0JPL4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/866895:HBHAL_RS10320 ^@ http://purl.uniprot.org/uniprot/I0JMT6 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/866895:HBHAL_RS10820 ^@ http://purl.uniprot.org/uniprot/I0JN40 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SbcD family.|||Heterodimer of SbcC and SbcD.|||SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. http://togogenome.org/gene/866895:HBHAL_RS03100 ^@ http://purl.uniprot.org/uniprot/I0JIK2 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/866895:HBHAL_RS00120 ^@ http://purl.uniprot.org/uniprot/I0JGY9 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein ModA family. http://togogenome.org/gene/866895:HBHAL_RS03010 ^@ http://purl.uniprot.org/uniprot/I0JII4 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS18790 ^@ http://purl.uniprot.org/uniprot/I0JSV2 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/866895:HBHAL_RS02880 ^@ http://purl.uniprot.org/uniprot/I0JIF7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS12330 ^@ http://purl.uniprot.org/uniprot/I0JP06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14300 ^@ http://purl.uniprot.org/uniprot/I0JQ52 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/866895:HBHAL_RS16955 ^@ http://purl.uniprot.org/uniprot/I0JRR9 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/866895:HBHAL_RS18285 ^@ http://purl.uniprot.org/uniprot/I0JSJ2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS09440 ^@ http://purl.uniprot.org/uniprot/I0JMA2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS01785 ^@ http://purl.uniprot.org/uniprot/I0JHU9 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/866895:HBHAL_RS12055 ^@ http://purl.uniprot.org/uniprot/I0JNV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/866895:HBHAL_RS00670 ^@ http://purl.uniprot.org/uniprot/I0JH80 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/866895:HBHAL_RS14775 ^@ http://purl.uniprot.org/uniprot/I0JQE6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/866895:HBHAL_RS04370 ^@ http://purl.uniprot.org/uniprot/I0JJC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11645 ^@ http://purl.uniprot.org/uniprot/I0JNL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS17415 ^@ http://purl.uniprot.org/uniprot/I0JS15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/866895:HBHAL_RS14360 ^@ http://purl.uniprot.org/uniprot/I0JQ65 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS16605 ^@ http://purl.uniprot.org/uniprot/I0JRI7 ^@ Similarity ^@ Belongs to the acyltransferase 3 family. http://togogenome.org/gene/866895:HBHAL_RS05110 ^@ http://purl.uniprot.org/uniprot/I0JJS3 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase subunit B family. http://togogenome.org/gene/866895:HBHAL_RS17690 ^@ http://purl.uniprot.org/uniprot/I0JS74 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the octanoyltransferase LipL family.|||Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.|||The reaction proceeds via a thioester-linked acyl-enzyme intermediate. http://togogenome.org/gene/866895:HBHAL_RS03445 ^@ http://purl.uniprot.org/uniprot/I0JIS9 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/866895:HBHAL_RS15035 ^@ http://purl.uniprot.org/uniprot/I0JQK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.|||Belongs to the CsrA/RsmA family.|||Cytoplasm|||Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core. http://togogenome.org/gene/866895:HBHAL_RS13325 ^@ http://purl.uniprot.org/uniprot/I0JPJ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS09700 ^@ http://purl.uniprot.org/uniprot/I0JMF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. EmrB family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS19035 ^@ http://purl.uniprot.org/uniprot/I0JT02 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/866895:HBHAL_RS10000 ^@ http://purl.uniprot.org/uniprot/I0JML8 ^@ Similarity ^@ Belongs to the flagella basal body rod proteins family. http://togogenome.org/gene/866895:HBHAL_RS18975 ^@ http://purl.uniprot.org/uniprot/I0JSZ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TenA family.|||Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS09360 ^@ http://purl.uniprot.org/uniprot/I0JM86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/866895:HBHAL_RS09800 ^@ http://purl.uniprot.org/uniprot/I0JMH8 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/866895:HBHAL_RS05015 ^@ http://purl.uniprot.org/uniprot/I0JJQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS07830 ^@ http://purl.uniprot.org/uniprot/I0JLA3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the serine/threonine dehydratase family.|||Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.|||In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers). http://togogenome.org/gene/866895:HBHAL_RS12545 ^@ http://purl.uniprot.org/uniprot/I0JP45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS07020 ^@ http://purl.uniprot.org/uniprot/I0JKU3 ^@ Similarity ^@ Belongs to the TelA family. http://togogenome.org/gene/866895:HBHAL_RS17610 ^@ http://purl.uniprot.org/uniprot/I0JS58 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS05260 ^@ http://purl.uniprot.org/uniprot/I0JJV5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS14265 ^@ http://purl.uniprot.org/uniprot/I0JQ45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13120 ^@ http://purl.uniprot.org/uniprot/I0JPG1 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/866895:HBHAL_RS12550 ^@ http://purl.uniprot.org/uniprot/I0JP46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS12310 ^@ http://purl.uniprot.org/uniprot/I0JP00 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/866895:HBHAL_RS10745 ^@ http://purl.uniprot.org/uniprot/I0JN25 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/866895:HBHAL_RS03085 ^@ http://purl.uniprot.org/uniprot/I0JIJ9 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/866895:HBHAL_RS17335 ^@ http://purl.uniprot.org/uniprot/I0JRZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/866895:HBHAL_RS15690 ^@ http://purl.uniprot.org/uniprot/I0JQY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS11125 ^@ http://purl.uniprot.org/uniprot/I0JNA5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/866895:HBHAL_RS14350 ^@ http://purl.uniprot.org/uniprot/I0JQ63 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/866895:HBHAL_RS08470 ^@ http://purl.uniprot.org/uniprot/I0JLP3 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/866895:HBHAL_RS13005 ^@ http://purl.uniprot.org/uniprot/I0JPD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MinC family.|||Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.|||Interacts with MinD and FtsZ. http://togogenome.org/gene/866895:HBHAL_RS20555 ^@ http://purl.uniprot.org/uniprot/I0JJP9 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/866895:HBHAL_RS03015 ^@ http://purl.uniprot.org/uniprot/I0JII5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09120 ^@ http://purl.uniprot.org/uniprot/I0JM35 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcAL family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS10535 ^@ http://purl.uniprot.org/uniprot/I0JMY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/866895:HBHAL_RS13805 ^@ http://purl.uniprot.org/uniprot/I0JPU8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/866895:HBHAL_RS09845 ^@ http://purl.uniprot.org/uniprot/I0JMI7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/866895:HBHAL_RS00795 ^@ http://purl.uniprot.org/uniprot/I0JHA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/866895:HBHAL_RS10970 ^@ http://purl.uniprot.org/uniprot/I0JN73 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/866895:HBHAL_RS11410 ^@ http://purl.uniprot.org/uniprot/I0JNG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ScpA family.|||Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.|||Cytoplasm|||Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. http://togogenome.org/gene/866895:HBHAL_RS00925 ^@ http://purl.uniprot.org/uniprot/I0JHD2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer.|||In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.|||In the N-terminal section; belongs to the MIP18 family. http://togogenome.org/gene/866895:HBHAL_RS04745 ^@ http://purl.uniprot.org/uniprot/I0JJJ9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS02250 ^@ http://purl.uniprot.org/uniprot/I0JI24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/866895:HBHAL_RS05280 ^@ http://purl.uniprot.org/uniprot/I0JJV8 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS11735 ^@ http://purl.uniprot.org/uniprot/I0JNN0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PhyH family. EctD subfamily.|||Homodimer.|||Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine. http://togogenome.org/gene/866895:HBHAL_RS07780 ^@ http://purl.uniprot.org/uniprot/I0JL93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.|||Cell membrane|||Membrane|||Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. http://togogenome.org/gene/866895:HBHAL_RS14315 ^@ http://purl.uniprot.org/uniprot/I0JQ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16950 ^@ http://purl.uniprot.org/uniprot/I0JRR8 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS18625 ^@ http://purl.uniprot.org/uniprot/I0JSR6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS05565 ^@ http://purl.uniprot.org/uniprot/I0JJZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GerABKA family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS20335 ^@ http://purl.uniprot.org/uniprot/I0JJM2 ^@ Similarity ^@ Belongs to the phosphoribulokinase family. http://togogenome.org/gene/866895:HBHAL_RS10485 ^@ http://purl.uniprot.org/uniprot/I0JMX0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS15685 ^@ http://purl.uniprot.org/uniprot/I0JQY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18290 ^@ http://purl.uniprot.org/uniprot/I0JSJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1C family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16535 ^@ http://purl.uniprot.org/uniprot/I0JRH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13920 ^@ http://purl.uniprot.org/uniprot/I0JPW9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS14755 ^@ http://purl.uniprot.org/uniprot/I0JQE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS01065 ^@ http://purl.uniprot.org/uniprot/I0JHE5 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS18760 ^@ http://purl.uniprot.org/uniprot/I0JSU5 ^@ Similarity ^@ Belongs to the IucA/IucC family. http://togogenome.org/gene/866895:HBHAL_RS08415 ^@ http://purl.uniprot.org/uniprot/I0JLN2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS08325 ^@ http://purl.uniprot.org/uniprot/I0JLL2 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 FMN per subunit. http://togogenome.org/gene/866895:HBHAL_RS09785 ^@ http://purl.uniprot.org/uniprot/I0JMH5 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/866895:HBHAL_RS00625 ^@ http://purl.uniprot.org/uniprot/I0JH70 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS10085 ^@ http://purl.uniprot.org/uniprot/I0JMN6 ^@ Function|||Similarity ^@ Belongs to the CheD family.|||Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis. http://togogenome.org/gene/866895:HBHAL_RS15650 ^@ http://purl.uniprot.org/uniprot/I0JQX8 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS12345 ^@ http://purl.uniprot.org/uniprot/I0JP09 ^@ Similarity ^@ Belongs to the transpeptidase family. http://togogenome.org/gene/866895:HBHAL_RS09770 ^@ http://purl.uniprot.org/uniprot/I0JMH2 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/866895:HBHAL_RS11005 ^@ http://purl.uniprot.org/uniprot/I0JN81 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/866895:HBHAL_RS12635 ^@ http://purl.uniprot.org/uniprot/I0JP63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS14110 ^@ http://purl.uniprot.org/uniprot/I0JQ12 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/866895:HBHAL_RS10205 ^@ http://purl.uniprot.org/uniprot/I0JMR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/866895:HBHAL_RS08845 ^@ http://purl.uniprot.org/uniprot/I0JLX6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13655 ^@ http://purl.uniprot.org/uniprot/I0JPR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS10200 ^@ http://purl.uniprot.org/uniprot/I0JMR0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/866895:HBHAL_RS04025 ^@ http://purl.uniprot.org/uniprot/I0JJ51 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS17550 ^@ http://purl.uniprot.org/uniprot/I0JS46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/866895:HBHAL_RS20150 ^@ http://purl.uniprot.org/uniprot/I0JTM7 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/866895:HBHAL_RS15055 ^@ http://purl.uniprot.org/uniprot/I0JQK5 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the flagella basal body rod proteins family.|||Secreted http://togogenome.org/gene/866895:HBHAL_RS08545 ^@ http://purl.uniprot.org/uniprot/I0JLQ9 ^@ Similarity ^@ Belongs to the flavin oxidoreductase frp family. http://togogenome.org/gene/866895:HBHAL_RS09255 ^@ http://purl.uniprot.org/uniprot/I0JM64 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/866895:HBHAL_RS18230 ^@ http://purl.uniprot.org/uniprot/I0JSI0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the Cyclase 1 superfamily. KynB family.|||Binds 2 zinc ions per subunit.|||Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS19275 ^@ http://purl.uniprot.org/uniprot/I0JT51 ^@ Similarity ^@ Belongs to the sigma-54 factor family. http://togogenome.org/gene/866895:HBHAL_RS11790 ^@ http://purl.uniprot.org/uniprot/I0JNP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThiG family.|||Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.|||Cytoplasm|||Homotetramer. Forms heterodimers with either ThiH or ThiS. http://togogenome.org/gene/866895:HBHAL_RS12980 ^@ http://purl.uniprot.org/uniprot/I0JPD3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/866895:HBHAL_RS00585 ^@ http://purl.uniprot.org/uniprot/I0JH62 ^@ Similarity ^@ Belongs to the CtsR family. http://togogenome.org/gene/866895:HBHAL_RS05855 ^@ http://purl.uniprot.org/uniprot/I0JK50 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/866895:HBHAL_RS05245 ^@ http://purl.uniprot.org/uniprot/I0JJV0 ^@ Similarity ^@ Belongs to the UPF0374 family. http://togogenome.org/gene/866895:HBHAL_RS00840 ^@ http://purl.uniprot.org/uniprot/I0JHB4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS19465 ^@ http://purl.uniprot.org/uniprot/I0JT87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07590 ^@ http://purl.uniprot.org/uniprot/I0JL56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13625 ^@ http://purl.uniprot.org/uniprot/I0JPR1 ^@ Function|||Similarity ^@ Belongs to the MoaB/Mog family.|||May be involved in the biosynthesis of molybdopterin. http://togogenome.org/gene/866895:HBHAL_RS12050 ^@ http://purl.uniprot.org/uniprot/I0JNU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/866895:HBHAL_RS17695 ^@ http://purl.uniprot.org/uniprot/I0JS75 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/866895:HBHAL_RS06910 ^@ http://purl.uniprot.org/uniprot/I0JKS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS03050 ^@ http://purl.uniprot.org/uniprot/I0JIJ2 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/866895:HBHAL_RS16925 ^@ http://purl.uniprot.org/uniprot/I0JRR3 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/866895:HBHAL_RS15025 ^@ http://purl.uniprot.org/uniprot/I0JQJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliS family.|||cytosol http://togogenome.org/gene/866895:HBHAL_RS06365 ^@ http://purl.uniprot.org/uniprot/I0JKF4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08725 ^@ http://purl.uniprot.org/uniprot/I0JQV5 ^@ Similarity ^@ Belongs to the transposase 11 family. http://togogenome.org/gene/866895:HBHAL_RS15730 ^@ http://purl.uniprot.org/uniprot/I0JQZ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArsB family.|||Cell membrane|||Involved in arsenical resistance. Thought to form the channel of an arsenite pump.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10960 ^@ http://purl.uniprot.org/uniprot/I0JN71 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecU family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. http://togogenome.org/gene/866895:HBHAL_RS01675 ^@ http://purl.uniprot.org/uniprot/I0JHS8 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/866895:HBHAL_RS08290 ^@ http://purl.uniprot.org/uniprot/I0JLK5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAPS reductase family. CysH subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS02200 ^@ http://purl.uniprot.org/uniprot/I0JI15 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/866895:HBHAL_RS04485 ^@ http://purl.uniprot.org/uniprot/I0JJE8 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/866895:HBHAL_RS12060 ^@ http://purl.uniprot.org/uniprot/I0JNV1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS08850 ^@ http://purl.uniprot.org/uniprot/I0JLX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS20050 ^@ http://purl.uniprot.org/uniprot/I0JTK7 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with bS18 to 16S ribosomal RNA. http://togogenome.org/gene/866895:HBHAL_RS11955 ^@ http://purl.uniprot.org/uniprot/I0JNT0 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/866895:HBHAL_RS00355 ^@ http://purl.uniprot.org/uniprot/I0JH32 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/866895:HBHAL_RS13010 ^@ http://purl.uniprot.org/uniprot/I0JPD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12065 ^@ http://purl.uniprot.org/uniprot/I0JNV2 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/866895:HBHAL_RS10870 ^@ http://purl.uniprot.org/uniprot/I0JN50 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/866895:HBHAL_RS11305 ^@ http://purl.uniprot.org/uniprot/I0JNE1 ^@ Similarity ^@ Belongs to the manganese catalase family. http://togogenome.org/gene/866895:HBHAL_RS13795 ^@ http://purl.uniprot.org/uniprot/I0JPU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS15495 ^@ http://purl.uniprot.org/uniprot/I0JQU7 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase subunit B family. http://togogenome.org/gene/866895:HBHAL_RS07100 ^@ http://purl.uniprot.org/uniprot/I0JKW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11855 ^@ http://purl.uniprot.org/uniprot/I0JNQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.|||Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS16190 ^@ http://purl.uniprot.org/uniprot/I0JR95 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease beta subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/866895:HBHAL_RS13850 ^@ http://purl.uniprot.org/uniprot/I0JPV8 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/866895:HBHAL_RS20180 ^@ http://purl.uniprot.org/uniprot/I0JTN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.|||Cell membrane|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. http://togogenome.org/gene/866895:HBHAL_RS04550 ^@ http://purl.uniprot.org/uniprot/I0JJG1 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/866895:HBHAL_RS01835 ^@ http://purl.uniprot.org/uniprot/I0JHV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12000 ^@ http://purl.uniprot.org/uniprot/I0JNT9 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine. http://togogenome.org/gene/866895:HBHAL_RS03125 ^@ http://purl.uniprot.org/uniprot/I0JIK7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the GGGP/HepGP synthase family. Group I subfamily.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. http://togogenome.org/gene/866895:HBHAL_RS00735 ^@ http://purl.uniprot.org/uniprot/I0JH93 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/866895:HBHAL_RS06225 ^@ http://purl.uniprot.org/uniprot/I0JKC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10445 ^@ http://purl.uniprot.org/uniprot/I0JMW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0291 family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS08920 ^@ http://purl.uniprot.org/uniprot/I0JLZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS15340 ^@ http://purl.uniprot.org/uniprot/I0JQR1 ^@ Similarity ^@ Belongs to the acyltransferase 3 family. http://togogenome.org/gene/866895:HBHAL_RS17075 ^@ http://purl.uniprot.org/uniprot/I0JRU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M4 family.|||Extracellular zinc metalloprotease.|||Secreted http://togogenome.org/gene/866895:HBHAL_RS17405 ^@ http://purl.uniprot.org/uniprot/I0JS13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/866895:HBHAL_RS07730 ^@ http://purl.uniprot.org/uniprot/I0JL84 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.|||Belongs to the azoreductase type 1 family.|||Binds 1 FMN per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones. http://togogenome.org/gene/866895:HBHAL_RS20430 ^@ http://purl.uniprot.org/uniprot/I0JQG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS18115 ^@ http://purl.uniprot.org/uniprot/I0JSF6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/866895:HBHAL_RS19270 ^@ http://purl.uniprot.org/uniprot/I0JT50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS17990 ^@ http://purl.uniprot.org/uniprot/I0JSD4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10755 ^@ http://purl.uniprot.org/uniprot/I0JN27 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/866895:HBHAL_RS09375 ^@ http://purl.uniprot.org/uniprot/I0JM89 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/866895:HBHAL_RS03830 ^@ http://purl.uniprot.org/uniprot/I0JJ10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0182 family.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS08950 ^@ http://purl.uniprot.org/uniprot/I0JLZ9 ^@ Similarity ^@ Belongs to the UPF0637 family. http://togogenome.org/gene/866895:HBHAL_RS11275 ^@ http://purl.uniprot.org/uniprot/I0JND6 ^@ Similarity|||Subunit ^@ Belongs to the MecA family.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS07810 ^@ http://purl.uniprot.org/uniprot/I0JL99 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS03825 ^@ http://purl.uniprot.org/uniprot/I0JJ08 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/866895:HBHAL_RS17465 ^@ http://purl.uniprot.org/uniprot/I0JS26 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS01900 ^@ http://purl.uniprot.org/uniprot/I0JHX1 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/866895:HBHAL_RS09670 ^@ http://purl.uniprot.org/uniprot/I0JMF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.|||Catalyzes the conversion of pyruvate to formate and acetyl-CoA.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS07825 ^@ http://purl.uniprot.org/uniprot/I0JLA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/866895:HBHAL_RS01650 ^@ http://purl.uniprot.org/uniprot/I0JHS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS01760 ^@ http://purl.uniprot.org/uniprot/I0JHU4 ^@ Similarity ^@ Belongs to the diacylglycerol/lipid kinase family. http://togogenome.org/gene/866895:HBHAL_RS08330 ^@ http://purl.uniprot.org/uniprot/I0JLL3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.|||Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Binds 1 siroheme per subunit.|||Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. http://togogenome.org/gene/866895:HBHAL_RS06070 ^@ http://purl.uniprot.org/uniprot/I0JK92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS17545 ^@ http://purl.uniprot.org/uniprot/I0JS45 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS02395 ^@ http://purl.uniprot.org/uniprot/I0JI51 ^@ Similarity ^@ Belongs to the GbsR family. http://togogenome.org/gene/866895:HBHAL_RS07650 ^@ http://purl.uniprot.org/uniprot/I0JL66 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/866895:HBHAL_RS04150 ^@ http://purl.uniprot.org/uniprot/I0JJ77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/866895:HBHAL_RS02630 ^@ http://purl.uniprot.org/uniprot/I0JIA5 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/866895:HBHAL_RS13775 ^@ http://purl.uniprot.org/uniprot/I0JPU1 ^@ Similarity ^@ Belongs to the FtsK/SpoIIIE/SftA family. http://togogenome.org/gene/866895:HBHAL_RS00350 ^@ http://purl.uniprot.org/uniprot/I0JH31 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS08875 ^@ http://purl.uniprot.org/uniprot/I0JLY2 ^@ Function|||Similarity|||Subunit ^@ A non-essential component of RNA polymerase (RNAP).|||Belongs to the RNA polymerase subunit epsilon family.|||RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/866895:HBHAL_RS15930 ^@ http://purl.uniprot.org/uniprot/I0JR34 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lactate permease family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate. http://togogenome.org/gene/866895:HBHAL_RS01475 ^@ http://purl.uniprot.org/uniprot/I0JHN1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS07050 ^@ http://purl.uniprot.org/uniprot/I0JKV0 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/866895:HBHAL_RS14680 ^@ http://purl.uniprot.org/uniprot/I0JQC8 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/866895:HBHAL_RS14630 ^@ http://purl.uniprot.org/uniprot/I0JQB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HPr family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. http://togogenome.org/gene/866895:HBHAL_RS20110 ^@ http://purl.uniprot.org/uniprot/I0JTL9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS01595 ^@ http://purl.uniprot.org/uniprot/I0JHR1 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/866895:HBHAL_RS17575 ^@ http://purl.uniprot.org/uniprot/I0JS51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RpoE family.|||Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.|||RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors. http://togogenome.org/gene/866895:HBHAL_RS03150 ^@ http://purl.uniprot.org/uniprot/I0JIL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Catalyzes the sodium-dependent uptake of extracellular L-proline.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS02535 ^@ http://purl.uniprot.org/uniprot/I0JI83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10980 ^@ http://purl.uniprot.org/uniprot/I0JN75 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS15230 ^@ http://purl.uniprot.org/uniprot/I0JQN9 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/866895:HBHAL_RS10595 ^@ http://purl.uniprot.org/uniprot/I0JMZ3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/866895:HBHAL_RS04055 ^@ http://purl.uniprot.org/uniprot/I0JJ57 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS03430 ^@ http://purl.uniprot.org/uniprot/I0JIS6 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/866895:HBHAL_RS02795 ^@ http://purl.uniprot.org/uniprot/I0JIE1 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/866895:HBHAL_RS13735 ^@ http://purl.uniprot.org/uniprot/I0JPT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MotA family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18955 ^@ http://purl.uniprot.org/uniprot/I0JSY6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS04980 ^@ http://purl.uniprot.org/uniprot/I0JJP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12575 ^@ http://purl.uniprot.org/uniprot/I0JP51 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/866895:HBHAL_RS04650 ^@ http://purl.uniprot.org/uniprot/I0JJI1 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/866895:HBHAL_RS09905 ^@ http://purl.uniprot.org/uniprot/I0JMJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/866895:HBHAL_RS18925 ^@ http://purl.uniprot.org/uniprot/I0JSY0 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/866895:HBHAL_RS02090 ^@ http://purl.uniprot.org/uniprot/I0JI10 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SprT family.|||Binds 1 zinc ion.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS18495 ^@ http://purl.uniprot.org/uniprot/I0JSN8 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/866895:HBHAL_RS11515 ^@ http://purl.uniprot.org/uniprot/I0JNI4 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/866895:HBHAL_RS06475 ^@ http://purl.uniprot.org/uniprot/I0JKI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS00165 ^@ http://purl.uniprot.org/uniprot/I0JGZ8 ^@ Similarity ^@ Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family. http://togogenome.org/gene/866895:HBHAL_RS05860 ^@ http://purl.uniprot.org/uniprot/I0JK51 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS20185 ^@ http://purl.uniprot.org/uniprot/I0JTN5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/866895:HBHAL_RS13785 ^@ http://purl.uniprot.org/uniprot/I0JPU3 ^@ Similarity ^@ Belongs to the UPF0354 family. http://togogenome.org/gene/866895:HBHAL_RS06345 ^@ http://purl.uniprot.org/uniprot/I0JKF0 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/866895:HBHAL_RS15900 ^@ http://purl.uniprot.org/uniprot/I0JR28 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16830 ^@ http://purl.uniprot.org/uniprot/I0JRN8 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS05420 ^@ http://purl.uniprot.org/uniprot/I0JJW8 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/866895:HBHAL_RS00145 ^@ http://purl.uniprot.org/uniprot/I0JGZ4 ^@ Similarity ^@ Belongs to the antibiotic N-acetyltransferase family. http://togogenome.org/gene/866895:HBHAL_RS04570 ^@ http://purl.uniprot.org/uniprot/I0JJG5 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/866895:HBHAL_RS14585 ^@ http://purl.uniprot.org/uniprot/I0JQA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00805 ^@ http://purl.uniprot.org/uniprot/I0JHA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/866895:HBHAL_RS13515 ^@ http://purl.uniprot.org/uniprot/I0JPN8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS17605 ^@ http://purl.uniprot.org/uniprot/I0JS57 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS02625 ^@ http://purl.uniprot.org/uniprot/I0JIA3 ^@ Function ^@ Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function. http://togogenome.org/gene/866895:HBHAL_RS01055 ^@ http://purl.uniprot.org/uniprot/I0JHE4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS04415 ^@ http://purl.uniprot.org/uniprot/I0JJD4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/866895:HBHAL_RS02740 ^@ http://purl.uniprot.org/uniprot/I0JID0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS11155 ^@ http://purl.uniprot.org/uniprot/I0JNB1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MtrB family.|||Oligomer of 11 identical subunits arranged in doughnut-like structure.|||Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. http://togogenome.org/gene/866895:HBHAL_RS06275 ^@ http://purl.uniprot.org/uniprot/I0JKD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS05055 ^@ http://purl.uniprot.org/uniprot/I0JJR3 ^@ Cofactor|||Function|||Induction|||Similarity|||Subunit ^@ Belongs to the LuxS family.|||Binds 1 Fe cation per subunit.|||Expression is growth phase-dependent, with maximal expression in the mid-exponential growth phase. Induced by high salt concentrations (at protein level).|||Homodimer.|||Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity). http://togogenome.org/gene/866895:HBHAL_RS12915 ^@ http://purl.uniprot.org/uniprot/I0JPC0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvA family.|||Cytoplasm|||Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.|||Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA. http://togogenome.org/gene/866895:HBHAL_RS05450 ^@ http://purl.uniprot.org/uniprot/I0JJX3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/866895:HBHAL_RS15450 ^@ http://purl.uniprot.org/uniprot/I0JQT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS17005 ^@ http://purl.uniprot.org/uniprot/D9ZZC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18845 ^@ http://purl.uniprot.org/uniprot/I0JSW4 ^@ Similarity ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. http://togogenome.org/gene/866895:HBHAL_RS12830 ^@ http://purl.uniprot.org/uniprot/I0JPA2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS13015 ^@ http://purl.uniprot.org/uniprot/I0JPE0 ^@ Function|||Similarity ^@ Belongs to the MreC family.|||Involved in formation and maintenance of cell shape. http://togogenome.org/gene/866895:HBHAL_RS02065 ^@ http://purl.uniprot.org/uniprot/I0JI05 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/866895:HBHAL_RS17505 ^@ http://purl.uniprot.org/uniprot/I0JS34 ^@ Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/866895:HBHAL_RS03790 ^@ http://purl.uniprot.org/uniprot/I0JJ00 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/866895:HBHAL_RS05660 ^@ http://purl.uniprot.org/uniprot/I0JK12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS16930 ^@ http://purl.uniprot.org/uniprot/I0JRR4 ^@ Cofactor|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/866895:HBHAL_RS13470 ^@ http://purl.uniprot.org/uniprot/I0JPM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS18385 ^@ http://purl.uniprot.org/uniprot/I0JSL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16180 ^@ http://purl.uniprot.org/uniprot/I0JR93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UreE family.|||Cytoplasm|||Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. http://togogenome.org/gene/866895:HBHAL_RS13615 ^@ http://purl.uniprot.org/uniprot/I0JPQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07250 ^@ http://purl.uniprot.org/uniprot/I0JKZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12970 ^@ http://purl.uniprot.org/uniprot/I0JPD1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/866895:HBHAL_RS20040 ^@ http://purl.uniprot.org/uniprot/I0JTK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6. http://togogenome.org/gene/866895:HBHAL_RS02015 ^@ http://purl.uniprot.org/uniprot/I0JHZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/866895:HBHAL_RS17140 ^@ http://purl.uniprot.org/uniprot/I0JRW0 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/866895:HBHAL_RS15380 ^@ http://purl.uniprot.org/uniprot/I0JQR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09765 ^@ http://purl.uniprot.org/uniprot/I0JMH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00630 ^@ http://purl.uniprot.org/uniprot/I0JH71 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/866895:HBHAL_RS11160 ^@ http://purl.uniprot.org/uniprot/I0JNB2 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/866895:HBHAL_RS18970 ^@ http://purl.uniprot.org/uniprot/I0JSY9 ^@ Similarity ^@ Belongs to the ThiD family. http://togogenome.org/gene/866895:HBHAL_RS00490 ^@ http://purl.uniprot.org/uniprot/I0JH58 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/866895:HBHAL_RS11485 ^@ http://purl.uniprot.org/uniprot/I0JNH8 ^@ Function|||Similarity ^@ Belongs to the peptidase S11 family.|||Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. http://togogenome.org/gene/866895:HBHAL_RS13270 ^@ http://purl.uniprot.org/uniprot/I0JPI6 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/866895:HBHAL_RS09005 ^@ http://purl.uniprot.org/uniprot/I0JM10 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/866895:HBHAL_RS08870 ^@ http://purl.uniprot.org/uniprot/I0JLY1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/866895:HBHAL_RS06535 ^@ http://purl.uniprot.org/uniprot/I0JKJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArsC family. Spx subfamily.|||Cytoplasm|||Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.|||Interacts with the C-terminal domain of the alpha subunit of the RNAP. http://togogenome.org/gene/866895:HBHAL_RS14765 ^@ http://purl.uniprot.org/uniprot/I0JQE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS12440 ^@ http://purl.uniprot.org/uniprot/I0JP22 ^@ PTM ^@ Binds 1 heme c group covalently per subunit. http://togogenome.org/gene/866895:HBHAL_RS16700 ^@ http://purl.uniprot.org/uniprot/I0JRK7 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/866895:HBHAL_RS16235 ^@ http://purl.uniprot.org/uniprot/I0JRA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/866895:HBHAL_RS09495 ^@ http://purl.uniprot.org/uniprot/I0JMB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS00675 ^@ http://purl.uniprot.org/uniprot/I0JH81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/866895:HBHAL_RS03820 ^@ http://purl.uniprot.org/uniprot/I0JJ07 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/866895:HBHAL_RS17160 ^@ http://purl.uniprot.org/uniprot/I0JRW4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/866895:HBHAL_RS09320 ^@ http://purl.uniprot.org/uniprot/I0JM78 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/866895:HBHAL_RS18150 ^@ http://purl.uniprot.org/uniprot/I0JSG4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20B family.|||Binds 2 Zn(2+) ions per subunit.|||Cleaves the N-terminal amino acid of tripeptides.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS05285 ^@ http://purl.uniprot.org/uniprot/I0JJV9 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/866895:HBHAL_RS04405 ^@ http://purl.uniprot.org/uniprot/I0JJD2 ^@ Similarity ^@ Belongs to the mannitol dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS15375 ^@ http://purl.uniprot.org/uniprot/I0JQR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18120 ^@ http://purl.uniprot.org/uniprot/I0JSF7 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/866895:HBHAL_RS13730 ^@ http://purl.uniprot.org/uniprot/I0JPT2 ^@ Similarity ^@ Belongs to the MotB family. http://togogenome.org/gene/866895:HBHAL_RS04460 ^@ http://purl.uniprot.org/uniprot/I0JJE3 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/866895:HBHAL_RS00045 ^@ http://purl.uniprot.org/uniprot/I0JGX6 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/866895:HBHAL_RS13125 ^@ http://purl.uniprot.org/uniprot/I0JPG2 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/866895:HBHAL_RS11520 ^@ http://purl.uniprot.org/uniprot/I0JNI5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Component of the MPD complex composed of SpoIIM, SpoIIP and SpoIID.|||Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane. http://togogenome.org/gene/866895:HBHAL_RS10875 ^@ http://purl.uniprot.org/uniprot/I0JN52 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS00615 ^@ http://purl.uniprot.org/uniprot/I0JH68 ^@ Similarity ^@ Belongs to the asparaginase 1 family.|||Belongs to the ycf81 family. http://togogenome.org/gene/866895:HBHAL_RS00825 ^@ http://purl.uniprot.org/uniprot/I0JHB1 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS11635 ^@ http://purl.uniprot.org/uniprot/I0JNK8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS12580 ^@ http://purl.uniprot.org/uniprot/I0JP52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/866895:HBHAL_RS17585 ^@ http://purl.uniprot.org/uniprot/I0JS53 ^@ Caution|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the IcmF family.|||Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.|||Homodimer.|||Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS08790 ^@ http://purl.uniprot.org/uniprot/I0JLW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0073 (Hly-III) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09225 ^@ http://purl.uniprot.org/uniprot/I0JM57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/866895:HBHAL_RS02410 ^@ http://purl.uniprot.org/uniprot/I0JI55 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS19050 ^@ http://purl.uniprot.org/uniprot/I0JT05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13290 ^@ http://purl.uniprot.org/uniprot/I0JPJ0 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/866895:HBHAL_RS11900 ^@ http://purl.uniprot.org/uniprot/I0JNR7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. http://togogenome.org/gene/866895:HBHAL_RS09775 ^@ http://purl.uniprot.org/uniprot/I0JMH3 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/866895:HBHAL_RS04990 ^@ http://purl.uniprot.org/uniprot/I0JJQ0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS13525 ^@ http://purl.uniprot.org/uniprot/I0JPP0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS13485 ^@ http://purl.uniprot.org/uniprot/I0JPN2 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Belongs to the LDH/MDH superfamily. MDH type 3 family.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/866895:HBHAL_RS08295 ^@ http://purl.uniprot.org/uniprot/I0JLK6 ^@ Similarity ^@ Belongs to the sulfate adenylyltransferase family. http://togogenome.org/gene/866895:HBHAL_RS02810 ^@ http://purl.uniprot.org/uniprot/I0JIE4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS10110 ^@ http://purl.uniprot.org/uniprot/I0JMP3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS09870 ^@ http://purl.uniprot.org/uniprot/I0JMJ2 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/866895:HBHAL_RS21905 ^@ http://purl.uniprot.org/uniprot/I0JHU6 ^@ Similarity ^@ Belongs to the transglycosylase Slt family. http://togogenome.org/gene/866895:HBHAL_RS10330 ^@ http://purl.uniprot.org/uniprot/I0JMT8 ^@ Function|||Similarity ^@ Belongs to the RNase Y family.|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/866895:HBHAL_RS19245 ^@ http://purl.uniprot.org/uniprot/I0JT46 ^@ Function|||Similarity ^@ Belongs to the catalase family. HPII subfamily.|||Serves to protect cells from the toxic effects of hydrogen peroxide. http://togogenome.org/gene/866895:HBHAL_RS15100 ^@ http://purl.uniprot.org/uniprot/I0JQL4 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/866895:HBHAL_RS04675 ^@ http://purl.uniprot.org/uniprot/I0JJI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS19055 ^@ http://purl.uniprot.org/uniprot/I0JT06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09810 ^@ http://purl.uniprot.org/uniprot/I0JMI0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS10590 ^@ http://purl.uniprot.org/uniprot/I0JMZ2 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/866895:HBHAL_RS17165 ^@ http://purl.uniprot.org/uniprot/I0JRW5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS01700 ^@ http://purl.uniprot.org/uniprot/I0JHT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS02915 ^@ http://purl.uniprot.org/uniprot/I0JIG5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/866895:HBHAL_RS18745 ^@ http://purl.uniprot.org/uniprot/I0JSU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12755 ^@ http://purl.uniprot.org/uniprot/I0JP88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS12480 ^@ http://purl.uniprot.org/uniprot/I0JP29 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/866895:HBHAL_RS12275 ^@ http://purl.uniprot.org/uniprot/I0JNZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LTA synthase family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS20170 ^@ http://purl.uniprot.org/uniprot/I0JTN1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS15215 ^@ http://purl.uniprot.org/uniprot/I0JQN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06160 ^@ http://purl.uniprot.org/uniprot/I0JKB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS13355 ^@ http://purl.uniprot.org/uniprot/I0JPK4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/866895:HBHAL_RS14320 ^@ http://purl.uniprot.org/uniprot/I0JQ57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13295 ^@ http://purl.uniprot.org/uniprot/I0JPJ1 ^@ Cofactor|||Similarity ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer. http://togogenome.org/gene/866895:HBHAL_RS16205 ^@ http://purl.uniprot.org/uniprot/I0JR98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14375 ^@ http://purl.uniprot.org/uniprot/D9ZZC4 ^@ Cofactor ^@ Binds 1 FAD per subunit. http://togogenome.org/gene/866895:HBHAL_RS06130 ^@ http://purl.uniprot.org/uniprot/I0JKA6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS00330 ^@ http://purl.uniprot.org/uniprot/I0JH27 ^@ Similarity ^@ Belongs to the alpha/beta-type SASP family. http://togogenome.org/gene/866895:HBHAL_RS09310 ^@ http://purl.uniprot.org/uniprot/I0JM76 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/866895:HBHAL_RS19335 ^@ http://purl.uniprot.org/uniprot/I0JT64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18400 ^@ http://purl.uniprot.org/uniprot/I0JSL8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/866895:HBHAL_RS07235 ^@ http://purl.uniprot.org/uniprot/I0JKZ0 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/866895:HBHAL_RS19805 ^@ http://purl.uniprot.org/uniprot/I0JTF8 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/866895:HBHAL_RS00875 ^@ http://purl.uniprot.org/uniprot/I0JHC1 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/866895:HBHAL_RS18275 ^@ http://purl.uniprot.org/uniprot/I0JSJ0 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/866895:HBHAL_RS03950 ^@ http://purl.uniprot.org/uniprot/I0JJ34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06040 ^@ http://purl.uniprot.org/uniprot/I0JK87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PrsA family.|||Cell membrane|||Membrane|||Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. http://togogenome.org/gene/866895:HBHAL_RS09415 ^@ http://purl.uniprot.org/uniprot/I0JM97 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/866895:HBHAL_RS16765 ^@ http://purl.uniprot.org/uniprot/I0JRM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS02400 ^@ http://purl.uniprot.org/uniprot/I0JI52 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS15725 ^@ http://purl.uniprot.org/uniprot/I0JQZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.|||Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS07635 ^@ http://purl.uniprot.org/uniprot/I0JL63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS09795 ^@ http://purl.uniprot.org/uniprot/I0JMH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/866895:HBHAL_RS10405 ^@ http://purl.uniprot.org/uniprot/I0JMV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS18395 ^@ http://purl.uniprot.org/uniprot/I0JSL7 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/866895:HBHAL_RS11195 ^@ http://purl.uniprot.org/uniprot/I0JNB9 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/866895:HBHAL_RS10125 ^@ http://purl.uniprot.org/uniprot/I0JMP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01490 ^@ http://purl.uniprot.org/uniprot/I0JHN5 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/866895:HBHAL_RS02530 ^@ http://purl.uniprot.org/uniprot/I0JI82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12540 ^@ http://purl.uniprot.org/uniprot/I0JP44 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/866895:HBHAL_RS12425 ^@ http://purl.uniprot.org/uniprot/I0JP19 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/866895:HBHAL_RS03175 ^@ http://purl.uniprot.org/uniprot/I0JIL8 ^@ Similarity ^@ Belongs to the diacylglycerol/lipid kinase family. http://togogenome.org/gene/866895:HBHAL_RS19915 ^@ http://purl.uniprot.org/uniprot/I0JTI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS09475 ^@ http://purl.uniprot.org/uniprot/I0JMB0 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/866895:HBHAL_RS12175 ^@ http://purl.uniprot.org/uniprot/I0JNX5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. C-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/866895:HBHAL_RS01480 ^@ http://purl.uniprot.org/uniprot/I0JHN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS17315 ^@ http://purl.uniprot.org/uniprot/I0JRZ5 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/866895:HBHAL_RS15805 ^@ http://purl.uniprot.org/uniprot/I0JR11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS02750 ^@ http://purl.uniprot.org/uniprot/I0JID2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/866895:HBHAL_RS18410 ^@ http://purl.uniprot.org/uniprot/I0JSM0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS16690 ^@ http://purl.uniprot.org/uniprot/I0JRK4 ^@ Similarity ^@ Belongs to the CpsD/CapB family. http://togogenome.org/gene/866895:HBHAL_RS00245 ^@ http://purl.uniprot.org/uniprot/I0JH10 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/866895:HBHAL_RS15000 ^@ http://purl.uniprot.org/uniprot/I0JQJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/866895:HBHAL_RS04720 ^@ http://purl.uniprot.org/uniprot/I0JJJ4 ^@ Function|||Similarity ^@ Belongs to the ROK (NagC/XylR) family.|||Transcriptional repressor of xylose-utilizing enzymes. http://togogenome.org/gene/866895:HBHAL_RS14620 ^@ http://purl.uniprot.org/uniprot/I0JQB6 ^@ Function|||Similarity ^@ Belongs to the carbohydrate kinase PfkB family. LacC subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate. http://togogenome.org/gene/866895:HBHAL_RS19370 ^@ http://purl.uniprot.org/uniprot/I0JT69 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/866895:HBHAL_RS09300 ^@ http://purl.uniprot.org/uniprot/I0JM74 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/866895:HBHAL_RS10450 ^@ http://purl.uniprot.org/uniprot/I0JMW3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS05035 ^@ http://purl.uniprot.org/uniprot/I0JJR0 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/866895:HBHAL_RS00190 ^@ http://purl.uniprot.org/uniprot/I0JH03 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS01600 ^@ http://purl.uniprot.org/uniprot/I0JHR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS20190 ^@ http://purl.uniprot.org/uniprot/I0JTN6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/866895:HBHAL_RS18325 ^@ http://purl.uniprot.org/uniprot/I0JSK1 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. L-methionine gamma-lyase subfamily. http://togogenome.org/gene/866895:HBHAL_RS01880 ^@ http://purl.uniprot.org/uniprot/I0JHW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00335 ^@ http://purl.uniprot.org/uniprot/I0JH28 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/866895:HBHAL_RS03845 ^@ http://purl.uniprot.org/uniprot/I0JJ14 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 1 family.|||Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS12960 ^@ http://purl.uniprot.org/uniprot/I0JPC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS09950 ^@ http://purl.uniprot.org/uniprot/I0JMK8 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliE family. http://togogenome.org/gene/866895:HBHAL_RS01315 ^@ http://purl.uniprot.org/uniprot/I0JHJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09205 ^@ http://purl.uniprot.org/uniprot/I0JM53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS08065 ^@ http://purl.uniprot.org/uniprot/I0JLF8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS09280 ^@ http://purl.uniprot.org/uniprot/I0JM70 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/866895:HBHAL_RS04730 ^@ http://purl.uniprot.org/uniprot/I0JJJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06235 ^@ http://purl.uniprot.org/uniprot/I0JKD0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. AddA subfamily.|||Heterodimer of AddA and AddB/RexB.|||The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities. http://togogenome.org/gene/866895:HBHAL_RS11585 ^@ http://purl.uniprot.org/uniprot/I0JNJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11010 ^@ http://purl.uniprot.org/uniprot/I0JN82 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/866895:HBHAL_RS07155 ^@ http://purl.uniprot.org/uniprot/I0JKX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10370 ^@ http://purl.uniprot.org/uniprot/I0JMU6 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/866895:HBHAL_RS09190 ^@ http://purl.uniprot.org/uniprot/I0JM50 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS18875 ^@ http://purl.uniprot.org/uniprot/I0JSX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11505 ^@ http://purl.uniprot.org/uniprot/I0JNI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/866895:HBHAL_RS14750 ^@ http://purl.uniprot.org/uniprot/I0JQE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/866895:HBHAL_RS10140 ^@ http://purl.uniprot.org/uniprot/I0JMP9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS12155 ^@ http://purl.uniprot.org/uniprot/I0JNX1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Central regulator of manganese homeostasis.|||Cytoplasm|||DNA binding is strongly activated by Mn(2+).|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS13835 ^@ http://purl.uniprot.org/uniprot/I0JPV5 ^@ Similarity ^@ Belongs to the diacylglycerol/lipid kinase family. http://togogenome.org/gene/866895:HBHAL_RS12150 ^@ http://purl.uniprot.org/uniprot/I0JNX0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS06495 ^@ http://purl.uniprot.org/uniprot/I0JKI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08815 ^@ http://purl.uniprot.org/uniprot/I0JLX0 ^@ Similarity ^@ Belongs to the UPF0180 family. http://togogenome.org/gene/866895:HBHAL_RS00140 ^@ http://purl.uniprot.org/uniprot/I0JGZ3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS03995 ^@ http://purl.uniprot.org/uniprot/I0JJ45 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS07740 ^@ http://purl.uniprot.org/uniprot/I0JL86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07805 ^@ http://purl.uniprot.org/uniprot/I0JL98 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS05700 ^@ http://purl.uniprot.org/uniprot/I0JK20 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/866895:HBHAL_RS14280 ^@ http://purl.uniprot.org/uniprot/I0JQ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS04775 ^@ http://purl.uniprot.org/uniprot/I0JJK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS18765 ^@ http://purl.uniprot.org/uniprot/I0JSU6 ^@ Similarity ^@ Belongs to the IucA/IucC family. http://togogenome.org/gene/866895:HBHAL_RS04135 ^@ http://purl.uniprot.org/uniprot/I0JJ74 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/866895:HBHAL_RS08155 ^@ http://purl.uniprot.org/uniprot/I0JLH6 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/866895:HBHAL_RS13335 ^@ http://purl.uniprot.org/uniprot/I0JPK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13810 ^@ http://purl.uniprot.org/uniprot/I0JPU9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/866895:HBHAL_RS09955 ^@ http://purl.uniprot.org/uniprot/I0JMK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliF family.|||Membrane|||The M ring may be actively involved in energy transduction. http://togogenome.org/gene/866895:HBHAL_RS11255 ^@ http://purl.uniprot.org/uniprot/I0JND2 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/866895:HBHAL_RS11565 ^@ http://purl.uniprot.org/uniprot/I0JNJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS18280 ^@ http://purl.uniprot.org/uniprot/I0JSJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS18860 ^@ http://purl.uniprot.org/uniprot/I0JSW7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/866895:HBHAL_RS14770 ^@ http://purl.uniprot.org/uniprot/I0JQE5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/866895:HBHAL_RS17100 ^@ http://purl.uniprot.org/uniprot/I0JRV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. GalK subfamily.|||Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS19200 ^@ http://purl.uniprot.org/uniprot/I0JT35 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/866895:HBHAL_RS05580 ^@ http://purl.uniprot.org/uniprot/I0JJZ6 ^@ Similarity ^@ Belongs to the GerABKC lipoprotein family. http://togogenome.org/gene/866895:HBHAL_RS19160 ^@ http://purl.uniprot.org/uniprot/I0JT27 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS11360 ^@ http://purl.uniprot.org/uniprot/I0JNF3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS19440 ^@ http://purl.uniprot.org/uniprot/I0JT83 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS12875 ^@ http://purl.uniprot.org/uniprot/I0JPB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18795 ^@ http://purl.uniprot.org/uniprot/I0JSV3 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/866895:HBHAL_RS11000 ^@ http://purl.uniprot.org/uniprot/I0JN80 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanD family.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.|||Cytoplasm|||Heterooctamer of four alpha and four beta subunits.|||Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus. http://togogenome.org/gene/866895:HBHAL_RS12555 ^@ http://purl.uniprot.org/uniprot/I0JP47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/866895:HBHAL_RS11930 ^@ http://purl.uniprot.org/uniprot/I0JNS4 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/866895:HBHAL_RS00865 ^@ http://purl.uniprot.org/uniprot/I0JHB9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/866895:HBHAL_RS10275 ^@ http://purl.uniprot.org/uniprot/I0JMS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS18300 ^@ http://purl.uniprot.org/uniprot/I0JSJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase D family. Cardiolipin synthase subfamily.|||Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12475 ^@ http://purl.uniprot.org/uniprot/I0JP28 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/866895:HBHAL_RS07135 ^@ http://purl.uniprot.org/uniprot/I0JKX0 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/866895:HBHAL_RS09435 ^@ http://purl.uniprot.org/uniprot/I0JMA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS20470 ^@ http://purl.uniprot.org/uniprot/I0JRM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the methyl-accepting chemotaxis (MCP) protein family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06985 ^@ http://purl.uniprot.org/uniprot/I0JKT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lactate permease family.|||Cell membrane|||Membrane|||Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate. http://togogenome.org/gene/866895:HBHAL_RS09215 ^@ http://purl.uniprot.org/uniprot/I0JM55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FtsQ/DivIB family. DivIB subfamily.|||Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS11015 ^@ http://purl.uniprot.org/uniprot/I0JN83 ^@ Caution|||Function|||Similarity ^@ Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.|||Belongs to the biotin--protein ligase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS02075 ^@ http://purl.uniprot.org/uniprot/I0JI07 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/866895:HBHAL_RS02910 ^@ http://purl.uniprot.org/uniprot/I0JIG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05050 ^@ http://purl.uniprot.org/uniprot/A1DZZ3 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. YrrT family.|||Could be a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/866895:HBHAL_RS07815 ^@ http://purl.uniprot.org/uniprot/I0JLA0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS17595 ^@ http://purl.uniprot.org/uniprot/I0JS55 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/866895:HBHAL_RS12825 ^@ http://purl.uniprot.org/uniprot/I0JPA1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS02710 ^@ http://purl.uniprot.org/uniprot/I0JIC2 ^@ Function|||Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate. http://togogenome.org/gene/866895:HBHAL_RS13980 ^@ http://purl.uniprot.org/uniprot/I0JPY4 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS17780 ^@ http://purl.uniprot.org/uniprot/I0JS91 ^@ Similarity ^@ Belongs to the acyltransferase 3 family. http://togogenome.org/gene/866895:HBHAL_RS13880 ^@ http://purl.uniprot.org/uniprot/I0JPW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS04665 ^@ http://purl.uniprot.org/uniprot/I0JJI4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/866895:HBHAL_RS03575 ^@ http://purl.uniprot.org/uniprot/I0JIV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08225 ^@ http://purl.uniprot.org/uniprot/I0JLI9 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/866895:HBHAL_RS09035 ^@ http://purl.uniprot.org/uniprot/I0JM17 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS20045 ^@ http://purl.uniprot.org/uniprot/I0JTK6 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/866895:HBHAL_RS09025 ^@ http://purl.uniprot.org/uniprot/I0JM15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01425 ^@ http://purl.uniprot.org/uniprot/I0JHL9 ^@ Similarity ^@ Belongs to the peptidase S51 family. http://togogenome.org/gene/866895:HBHAL_RS04750 ^@ http://purl.uniprot.org/uniprot/I0JJK0 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate. http://togogenome.org/gene/866895:HBHAL_RS05945 ^@ http://purl.uniprot.org/uniprot/I0JK68 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/866895:HBHAL_RS07840 ^@ http://purl.uniprot.org/uniprot/I0JLA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS03960 ^@ http://purl.uniprot.org/uniprot/I0JJ37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS05405 ^@ http://purl.uniprot.org/uniprot/I0JJW5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/866895:HBHAL_RS14675 ^@ http://purl.uniprot.org/uniprot/I0JQC7 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS09265 ^@ http://purl.uniprot.org/uniprot/I0JM66 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/866895:HBHAL_RS13990 ^@ http://purl.uniprot.org/uniprot/I0JPY6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family. MenD subfamily.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS06860 ^@ http://purl.uniprot.org/uniprot/I0JKR2 ^@ Similarity ^@ Belongs to the RibF family. http://togogenome.org/gene/866895:HBHAL_RS15990 ^@ http://purl.uniprot.org/uniprot/I0JR49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.|||Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS10400 ^@ http://purl.uniprot.org/uniprot/I0JMV1 ^@ Similarity ^@ Belongs to the CbxX/CfxQ family. http://togogenome.org/gene/866895:HBHAL_RS10390 ^@ http://purl.uniprot.org/uniprot/I0JMU9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS10520 ^@ http://purl.uniprot.org/uniprot/I0JMX8 ^@ Similarity ^@ Belongs to the HesB/IscA family. http://togogenome.org/gene/866895:HBHAL_RS12585 ^@ http://purl.uniprot.org/uniprot/I0JP53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/866895:HBHAL_RS11215 ^@ http://purl.uniprot.org/uniprot/I0JNC3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS19965 ^@ http://purl.uniprot.org/uniprot/I0JTJ2 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/866895:HBHAL_RS07210 ^@ http://purl.uniprot.org/uniprot/I0JKY5 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/866895:HBHAL_RS10995 ^@ http://purl.uniprot.org/uniprot/I0JN79 ^@ Function|||Similarity ^@ 3'-5' exonuclease.|||Belongs to the helicase family. DinG subfamily. Type 2 sub-subfamily. http://togogenome.org/gene/866895:HBHAL_RS18580 ^@ http://purl.uniprot.org/uniprot/I0JSQ7 ^@ Function|||Similarity ^@ Belongs to the TrhO family.|||Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. http://togogenome.org/gene/866895:HBHAL_RS09935 ^@ http://purl.uniprot.org/uniprot/I0JMK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CodY family.|||Cytoplasm|||DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion. http://togogenome.org/gene/866895:HBHAL_RS02720 ^@ http://purl.uniprot.org/uniprot/I0JIC6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS06425 ^@ http://purl.uniprot.org/uniprot/I0JKG8 ^@ Similarity ^@ Belongs to the MoaD family. http://togogenome.org/gene/866895:HBHAL_RS10065 ^@ http://purl.uniprot.org/uniprot/I0JMN1 ^@ Similarity ^@ Belongs to the ParA family. MinD subfamily. http://togogenome.org/gene/866895:HBHAL_RS12180 ^@ http://purl.uniprot.org/uniprot/I0JNX6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/866895:HBHAL_RS02070 ^@ http://purl.uniprot.org/uniprot/I0JI06 ^@ Function|||Similarity ^@ Belongs to the anti-sigma-factor family.|||Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). http://togogenome.org/gene/866895:HBHAL_RS16760 ^@ http://purl.uniprot.org/uniprot/I0JRM1 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.|||Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. http://togogenome.org/gene/866895:HBHAL_RS05770 ^@ http://purl.uniprot.org/uniprot/I0JK34 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/866895:HBHAL_RS08585 ^@ http://purl.uniprot.org/uniprot/I0JLR9 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/866895:HBHAL_RS06705 ^@ http://purl.uniprot.org/uniprot/I0JKN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14985 ^@ http://purl.uniprot.org/uniprot/I0JQJ0 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/866895:HBHAL_RS02425 ^@ http://purl.uniprot.org/uniprot/I0JI58 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS05820 ^@ http://purl.uniprot.org/uniprot/I0JK43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS16615 ^@ http://purl.uniprot.org/uniprot/I0JRI9 ^@ Similarity ^@ Belongs to the sulfate adenylyltransferase family. http://togogenome.org/gene/866895:HBHAL_RS06615 ^@ http://purl.uniprot.org/uniprot/I0JKK8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS04655 ^@ http://purl.uniprot.org/uniprot/I0JJI2 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/866895:HBHAL_RS14550 ^@ http://purl.uniprot.org/uniprot/I0JQA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CotF family.|||Spore coat http://togogenome.org/gene/866895:HBHAL_RS14635 ^@ http://purl.uniprot.org/uniprot/I0JQB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/866895:HBHAL_RS18430 ^@ http://purl.uniprot.org/uniprot/I0JSM5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS19040 ^@ http://purl.uniprot.org/uniprot/I0JT03 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS10855 ^@ http://purl.uniprot.org/uniprot/I0JN47 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS10525 ^@ http://purl.uniprot.org/uniprot/I0JMX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/866895:HBHAL_RS00775 ^@ http://purl.uniprot.org/uniprot/I0JHA1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/866895:HBHAL_RS18915 ^@ http://purl.uniprot.org/uniprot/I0JSX8 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS15575 ^@ http://purl.uniprot.org/uniprot/I0JQW4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS04575 ^@ http://purl.uniprot.org/uniprot/I0JJG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS03500 ^@ http://purl.uniprot.org/uniprot/I0JIU0 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/866895:HBHAL_RS10355 ^@ http://purl.uniprot.org/uniprot/I0JMU3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS12785 ^@ http://purl.uniprot.org/uniprot/I0JP93 ^@ Function|||Similarity ^@ Belongs to the RecD family. RecD-like subfamily.|||DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity. http://togogenome.org/gene/866895:HBHAL_RS12290 ^@ http://purl.uniprot.org/uniprot/I0JNZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GerABKA family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16620 ^@ http://purl.uniprot.org/uniprot/I0JRJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol monophosphatase superfamily. CysQ family.|||Cell membrane|||Converts adenosine-3',5'-bisphosphate (PAP) to AMP. http://togogenome.org/gene/866895:HBHAL_RS08855 ^@ http://purl.uniprot.org/uniprot/I0JLX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS11145 ^@ http://purl.uniprot.org/uniprot/I0JNA9 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/866895:HBHAL_RS05640 ^@ http://purl.uniprot.org/uniprot/I0JK08 ^@ Similarity ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family. http://togogenome.org/gene/866895:HBHAL_RS08910 ^@ http://purl.uniprot.org/uniprot/I0JLY9 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/866895:HBHAL_RS14505 ^@ http://purl.uniprot.org/uniprot/I0JQ93 ^@ Cofactor ^@ Can also use Mn(2+) ion. http://togogenome.org/gene/866895:HBHAL_RS08640 ^@ http://purl.uniprot.org/uniprot/I0JLT2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Monomer and homodimer. http://togogenome.org/gene/866895:HBHAL_RS02265 ^@ http://purl.uniprot.org/uniprot/I0JI27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12600 ^@ http://purl.uniprot.org/uniprot/I0JP56 ^@ Function|||PTM|||Similarity|||Subunit ^@ Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.|||Belongs to the peptidase A25 family.|||Homotetramer.|||Initiates the rapid degradation of small, acid-soluble proteins during spore germination. http://togogenome.org/gene/866895:HBHAL_RS18805 ^@ http://purl.uniprot.org/uniprot/I0JSV5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/866895:HBHAL_RS12840 ^@ http://purl.uniprot.org/uniprot/I0JPA5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS13995 ^@ http://purl.uniprot.org/uniprot/I0JPY7 ^@ Function|||Similarity ^@ Belongs to the isochorismate synthase family.|||Catalyzes the conversion of chorismate to isochorismate. http://togogenome.org/gene/866895:HBHAL_RS16840 ^@ http://purl.uniprot.org/uniprot/I0JRP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurJ/MviN family.|||Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18310 ^@ http://purl.uniprot.org/uniprot/I0JSJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 32 family.|||Cytoplasm|||Enables the bacterium to metabolize sucrose as a sole carbon source. http://togogenome.org/gene/866895:HBHAL_RS13030 ^@ http://purl.uniprot.org/uniprot/I0JPE3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/866895:HBHAL_RS00635 ^@ http://purl.uniprot.org/uniprot/I0JH72 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS12070 ^@ http://purl.uniprot.org/uniprot/I0JNV3 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/866895:HBHAL_RS14295 ^@ http://purl.uniprot.org/uniprot/I0JQ51 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. http://togogenome.org/gene/866895:HBHAL_RS19350 ^@ http://purl.uniprot.org/uniprot/I0JT66 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS00640 ^@ http://purl.uniprot.org/uniprot/I0JH73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MrnC RNase family.|||Cytoplasm|||Homodimer.|||Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors. http://togogenome.org/gene/866895:HBHAL_RS05250 ^@ http://purl.uniprot.org/uniprot/I0JJV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13825 ^@ http://purl.uniprot.org/uniprot/I0JPV2 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. http://togogenome.org/gene/866895:HBHAL_RS06595 ^@ http://purl.uniprot.org/uniprot/I0JKK4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS18870 ^@ http://purl.uniprot.org/uniprot/I0JSW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS09825 ^@ http://purl.uniprot.org/uniprot/I0JMI3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/866895:HBHAL_RS09290 ^@ http://purl.uniprot.org/uniprot/I0JM72 ^@ Function|||Similarity|||Subunit ^@ Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.|||Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.|||Homodimer and homohexamer; in equilibrium.|||Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. http://togogenome.org/gene/866895:HBHAL_RS17400 ^@ http://purl.uniprot.org/uniprot/I0JS12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/866895:HBHAL_RS00480 ^@ http://purl.uniprot.org/uniprot/I0JH56 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/866895:HBHAL_RS04290 ^@ http://purl.uniprot.org/uniprot/I0JJA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS04210 ^@ http://purl.uniprot.org/uniprot/I0JJ90 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/866895:HBHAL_RS02230 ^@ http://purl.uniprot.org/uniprot/I0JI20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. EmrB family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13320 ^@ http://purl.uniprot.org/uniprot/I0JPJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0719 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01260 ^@ http://purl.uniprot.org/uniprot/I0JHI3 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/866895:HBHAL_RS00700 ^@ http://purl.uniprot.org/uniprot/I0JH86 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/866895:HBHAL_RS13055 ^@ http://purl.uniprot.org/uniprot/I0JPE8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/866895:HBHAL_RS04480 ^@ http://purl.uniprot.org/uniprot/I0JJE7 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS00200 ^@ http://purl.uniprot.org/uniprot/I0JH05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/866895:HBHAL_RS17470 ^@ http://purl.uniprot.org/uniprot/I0JS27 ^@ Similarity ^@ Belongs to the UPF0340 family. http://togogenome.org/gene/866895:HBHAL_RS09350 ^@ http://purl.uniprot.org/uniprot/I0JM84 ^@ Similarity ^@ Belongs to the YicC/YloC family. http://togogenome.org/gene/866895:HBHAL_RS09880 ^@ http://purl.uniprot.org/uniprot/I0JMJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/866895:HBHAL_RS17045 ^@ http://purl.uniprot.org/uniprot/I0JRU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS04615 ^@ http://purl.uniprot.org/uniprot/I0JJH4 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/866895:HBHAL_RS05225 ^@ http://purl.uniprot.org/uniprot/I0JJU5 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs.|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/866895:HBHAL_RS10925 ^@ http://purl.uniprot.org/uniprot/I0JN63 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS04635 ^@ http://purl.uniprot.org/uniprot/I0JJH8 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/866895:HBHAL_RS12845 ^@ http://purl.uniprot.org/uniprot/I0JPA6 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/866895:HBHAL_RS12030 ^@ http://purl.uniprot.org/uniprot/I0JNU4 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/866895:HBHAL_RS02715 ^@ http://purl.uniprot.org/uniprot/I0JIC3 ^@ Function|||Similarity ^@ Belongs to the ectoine synthase family.|||Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant. http://togogenome.org/gene/866895:HBHAL_RS18435 ^@ http://purl.uniprot.org/uniprot/I0JSM6 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/866895:HBHAL_RS12335 ^@ http://purl.uniprot.org/uniprot/I0JP07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/866895:HBHAL_RS11035 ^@ http://purl.uniprot.org/uniprot/I0JN87 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/866895:HBHAL_RS14820 ^@ http://purl.uniprot.org/uniprot/I0JQF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07145 ^@ http://purl.uniprot.org/uniprot/I0JKX2 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/866895:HBHAL_RS19105 ^@ http://purl.uniprot.org/uniprot/I0JT15 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/866895:HBHAL_RS09380 ^@ http://purl.uniprot.org/uniprot/I0JM90 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/866895:HBHAL_RS17480 ^@ http://purl.uniprot.org/uniprot/I0JS29 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/866895:HBHAL_RS01505 ^@ http://purl.uniprot.org/uniprot/I0JHN8 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/866895:HBHAL_RS09535 ^@ http://purl.uniprot.org/uniprot/I0JMC2 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/866895:HBHAL_RS11970 ^@ http://purl.uniprot.org/uniprot/I0JNT3 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/866895:HBHAL_RS14810 ^@ http://purl.uniprot.org/uniprot/I0JQF2 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS18700 ^@ http://purl.uniprot.org/uniprot/I0JST2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS02495 ^@ http://purl.uniprot.org/uniprot/I0JI75 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 4 family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/866895:HBHAL_RS08825 ^@ http://purl.uniprot.org/uniprot/I0JLX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18520 ^@ http://purl.uniprot.org/uniprot/I0JSP4 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/866895:HBHAL_RS04825 ^@ http://purl.uniprot.org/uniprot/I0JJL5 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/866895:HBHAL_RS05645 ^@ http://purl.uniprot.org/uniprot/I0JK09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GerABKA family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS19425 ^@ http://purl.uniprot.org/uniprot/I0JT80 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/866895:HBHAL_RS12735 ^@ http://purl.uniprot.org/uniprot/I0JP84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS02815 ^@ http://purl.uniprot.org/uniprot/I0JIE5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/866895:HBHAL_RS00315 ^@ http://purl.uniprot.org/uniprot/I0JH24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/866895:HBHAL_RS09400 ^@ http://purl.uniprot.org/uniprot/I0JM94 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS09660 ^@ http://purl.uniprot.org/uniprot/I0JME8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS13170 ^@ http://purl.uniprot.org/uniprot/I0JPG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase bacterial subunit 4 family.|||Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09115 ^@ http://purl.uniprot.org/uniprot/I0JM34 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/866895:HBHAL_RS05680 ^@ http://purl.uniprot.org/uniprot/I0JK16 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08150 ^@ http://purl.uniprot.org/uniprot/I0JLH5 ^@ Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS17125 ^@ http://purl.uniprot.org/uniprot/I0JRV7 ^@ Function|||Similarity ^@ Belongs to the ROK (NagC/XylR) family.|||Transcriptional repressor of xylose-utilizing enzymes. http://togogenome.org/gene/866895:HBHAL_RS04065 ^@ http://purl.uniprot.org/uniprot/I0JJ59 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LamB/PxpA family.|||Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.|||Forms a complex composed of PxpA, PxpB and PxpC. http://togogenome.org/gene/866895:HBHAL_RS09170 ^@ http://purl.uniprot.org/uniprot/I0JM46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/866895:HBHAL_RS08085 ^@ http://purl.uniprot.org/uniprot/I0JLG2 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/866895:HBHAL_RS14135 ^@ http://purl.uniprot.org/uniprot/I0JQ17 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.|||Homohexamer; trimer of homodimers. http://togogenome.org/gene/866895:HBHAL_RS12890 ^@ http://purl.uniprot.org/uniprot/I0JPB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS11475 ^@ http://purl.uniprot.org/uniprot/I0JNH6 ^@ Function|||Similarity ^@ Belongs to the anti-sigma-factor family.|||Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. http://togogenome.org/gene/866895:HBHAL_RS14875 ^@ http://purl.uniprot.org/uniprot/I0JQG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/866895:HBHAL_RS02990 ^@ http://purl.uniprot.org/uniprot/I0JII0 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/866895:HBHAL_RS03145 ^@ http://purl.uniprot.org/uniprot/D9ZZC6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. RocA subfamily. http://togogenome.org/gene/866895:HBHAL_RS10115 ^@ http://purl.uniprot.org/uniprot/I0JMP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/866895:HBHAL_RS11165 ^@ http://purl.uniprot.org/uniprot/I0JNB3 ^@ Function|||Subcellular Location Annotation ^@ ATPase. Has a role at an early stage in the morphogenesis of the spore coat.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS00035 ^@ http://purl.uniprot.org/uniprot/I0JGX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/866895:HBHAL_RS06785 ^@ http://purl.uniprot.org/uniprot/I0JKP7 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS05500 ^@ http://purl.uniprot.org/uniprot/I0JJY1 ^@ Similarity ^@ Belongs to the GppA/Ppx family. http://togogenome.org/gene/866895:HBHAL_RS00830 ^@ http://purl.uniprot.org/uniprot/I0JHB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS02210 ^@ http://purl.uniprot.org/uniprot/I0JI17 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/866895:HBHAL_RS01365 ^@ http://purl.uniprot.org/uniprot/I0JHK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS01980 ^@ http://purl.uniprot.org/uniprot/I0JHY9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06060 ^@ http://purl.uniprot.org/uniprot/I0JK90 ^@ Similarity ^@ Belongs to the GbsR family. http://togogenome.org/gene/866895:HBHAL_RS05515 ^@ http://purl.uniprot.org/uniprot/I0JJY4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).|||Forms a 24-polypeptide structural core with octahedral symmetry. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3). http://togogenome.org/gene/866895:HBHAL_RS03160 ^@ http://purl.uniprot.org/uniprot/I0JIL5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/866895:HBHAL_RS13085 ^@ http://purl.uniprot.org/uniprot/I0JPF4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/866895:HBHAL_RS03055 ^@ http://purl.uniprot.org/uniprot/I0JIJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/866895:HBHAL_RS12795 ^@ http://purl.uniprot.org/uniprot/I0JP95 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS19310 ^@ http://purl.uniprot.org/uniprot/I0JT58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.|||Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS06505 ^@ http://purl.uniprot.org/uniprot/I0JKI6 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/866895:HBHAL_RS11975 ^@ http://purl.uniprot.org/uniprot/I0JNT4 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/866895:HBHAL_RS05825 ^@ http://purl.uniprot.org/uniprot/I0JK44 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/866895:HBHAL_RS04760 ^@ http://purl.uniprot.org/uniprot/I0JJK2 ^@ Similarity ^@ Belongs to the aldose epimerase family. http://togogenome.org/gene/866895:HBHAL_RS11545 ^@ http://purl.uniprot.org/uniprot/I0JNJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. EmrB family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14220 ^@ http://purl.uniprot.org/uniprot/I0JQ35 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily. NagD family.|||Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/866895:HBHAL_RS03075 ^@ http://purl.uniprot.org/uniprot/I0JIJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS12525 ^@ http://purl.uniprot.org/uniprot/I0JP41 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flotillin-like FloA family.|||Cell membrane|||Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.|||Homooligomerizes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/866895:HBHAL_RS04225 ^@ http://purl.uniprot.org/uniprot/I0JJ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS10035 ^@ http://purl.uniprot.org/uniprot/I0JMM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliP/MopC/SpaP family.|||Cell membrane|||Membrane|||Plays a role in the flagellum-specific transport system. http://togogenome.org/gene/866895:HBHAL_RS13670 ^@ http://purl.uniprot.org/uniprot/I0JPS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EzrA family.|||Cell membrane|||Membrane|||Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization. http://togogenome.org/gene/866895:HBHAL_RS04640 ^@ http://purl.uniprot.org/uniprot/I0JJH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the anthranilate synthase component I family.|||Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).|||Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. http://togogenome.org/gene/866895:HBHAL_RS03130 ^@ http://purl.uniprot.org/uniprot/I0JIK8 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/866895:HBHAL_RS14355 ^@ http://purl.uniprot.org/uniprot/I0JQ64 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/866895:HBHAL_RS12850 ^@ http://purl.uniprot.org/uniprot/I0JPA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS10155 ^@ http://purl.uniprot.org/uniprot/I0JMQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/866895:HBHAL_RS10020 ^@ http://purl.uniprot.org/uniprot/I0JMM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliN/MopA/SpaO family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01730 ^@ http://purl.uniprot.org/uniprot/I0JHT8 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the NOS family. Bacterial NOS oxygenase subfamily.|||Catalyzes the production of nitric oxide.|||Homodimer.|||This protein is similar to the oxygenase domain of eukaryotic nitric oxide synthases but lacks the reductase domain which, in eukaryotes, is responsible for transfer of electrons to the ferric heme during nitric oxide synthesis. http://togogenome.org/gene/866895:HBHAL_RS00080 ^@ http://purl.uniprot.org/uniprot/I0JGY3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/866895:HBHAL_RS20085 ^@ http://purl.uniprot.org/uniprot/I0JTL4 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/866895:HBHAL_RS06455 ^@ http://purl.uniprot.org/uniprot/I0JKH6 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/866895:HBHAL_RS12205 ^@ http://purl.uniprot.org/uniprot/I0JNY1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS10185 ^@ http://purl.uniprot.org/uniprot/I0JMQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/866895:HBHAL_RS13490 ^@ http://purl.uniprot.org/uniprot/I0JPN3 ^@ Cofactor ^@ Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/866895:HBHAL_RS13605 ^@ http://purl.uniprot.org/uniprot/I0JPQ6 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/866895:HBHAL_RS17760 ^@ http://purl.uniprot.org/uniprot/I0JS87 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/866895:HBHAL_RS13220 ^@ http://purl.uniprot.org/uniprot/I0JPH5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/866895:HBHAL_RS17225 ^@ http://purl.uniprot.org/uniprot/I0JRX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01570 ^@ http://purl.uniprot.org/uniprot/I0JHQ1 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/866895:HBHAL_RS16185 ^@ http://purl.uniprot.org/uniprot/I0JR94 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.|||Binds 2 nickel ions per subunit.|||Carbamylation allows a single lysine to coordinate two nickel ions.|||Carboxylation allows a single lysine to coordinate two nickel ions.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/866895:HBHAL_RS00295 ^@ http://purl.uniprot.org/uniprot/I0JH20 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS13225 ^@ http://purl.uniprot.org/uniprot/I0JPH6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/866895:HBHAL_RS00725 ^@ http://purl.uniprot.org/uniprot/I0JH91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/866895:HBHAL_RS15105 ^@ http://purl.uniprot.org/uniprot/I0JQL5 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/866895:HBHAL_RS06965 ^@ http://purl.uniprot.org/uniprot/I0JKT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the bacterial flagellin family.|||Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.|||Secreted http://togogenome.org/gene/866895:HBHAL_RS18595 ^@ http://purl.uniprot.org/uniprot/I0JSR0 ^@ Similarity ^@ Belongs to the ThiD family. http://togogenome.org/gene/866895:HBHAL_RS10015 ^@ http://purl.uniprot.org/uniprot/I0JMM1 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliM family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16935 ^@ http://purl.uniprot.org/uniprot/I0JRR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13385 ^@ http://purl.uniprot.org/uniprot/I0JPL1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13070 ^@ http://purl.uniprot.org/uniprot/I0JPF1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS09345 ^@ http://purl.uniprot.org/uniprot/I0JM83 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. http://togogenome.org/gene/866895:HBHAL_RS13365 ^@ http://purl.uniprot.org/uniprot/I0JPK6 ^@ Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SspI family.|||Expressed only in the forespore compartment of sporulating cells.|||Spore core http://togogenome.org/gene/866895:HBHAL_RS09305 ^@ http://purl.uniprot.org/uniprot/I0JM75 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/866895:HBHAL_RS00695 ^@ http://purl.uniprot.org/uniprot/I0JH85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/866895:HBHAL_RS12910 ^@ http://purl.uniprot.org/uniprot/I0JPB9 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Cytoplasm|||Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.|||Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA. http://togogenome.org/gene/866895:HBHAL_RS17155 ^@ http://purl.uniprot.org/uniprot/I0JRW3 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/866895:HBHAL_RS19120 ^@ http://purl.uniprot.org/uniprot/I0JT18 ^@ Similarity ^@ Belongs to the DinB family. http://togogenome.org/gene/866895:HBHAL_RS09990 ^@ http://purl.uniprot.org/uniprot/I0JML6 ^@ Similarity ^@ Belongs to the FlgD family. http://togogenome.org/gene/866895:HBHAL_RS01340 ^@ http://purl.uniprot.org/uniprot/I0JHJ8 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS10280 ^@ http://purl.uniprot.org/uniprot/I0JMS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12465 ^@ http://purl.uniprot.org/uniprot/I0JP26 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/866895:HBHAL_RS17365 ^@ http://purl.uniprot.org/uniprot/I0JS05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/866895:HBHAL_RS18835 ^@ http://purl.uniprot.org/uniprot/I0JSW2 ^@ Similarity ^@ Belongs to the GerABKC lipoprotein family. http://togogenome.org/gene/866895:HBHAL_RS13440 ^@ http://purl.uniprot.org/uniprot/I0JPM3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/866895:HBHAL_RS16210 ^@ http://purl.uniprot.org/uniprot/I0JR99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14535 ^@ http://purl.uniprot.org/uniprot/I0JQ99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS06140 ^@ http://purl.uniprot.org/uniprot/I0JKA9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DsbB family. BdbC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for disulfide bond formation in some proteins. http://togogenome.org/gene/866895:HBHAL_RS18950 ^@ http://purl.uniprot.org/uniprot/I0JSY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS14880 ^@ http://purl.uniprot.org/uniprot/I0JQG7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/866895:HBHAL_RS09930 ^@ http://purl.uniprot.org/uniprot/I0JMK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS00810 ^@ http://purl.uniprot.org/uniprot/I0JHA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/866895:HBHAL_RS03070 ^@ http://purl.uniprot.org/uniprot/I0JIJ6 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/866895:HBHAL_RS16595 ^@ http://purl.uniprot.org/uniprot/I0JRI6 ^@ Similarity ^@ Belongs to the acyltransferase 3 family. http://togogenome.org/gene/866895:HBHAL_RS06170 ^@ http://purl.uniprot.org/uniprot/I0JKB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III. http://togogenome.org/gene/866895:HBHAL_RS07705 ^@ http://purl.uniprot.org/uniprot/I0JL77 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01605 ^@ http://purl.uniprot.org/uniprot/I0JHR3 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/866895:HBHAL_RS12080 ^@ http://purl.uniprot.org/uniprot/I0JNV5 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/866895:HBHAL_RS15925 ^@ http://purl.uniprot.org/uniprot/I0JR33 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by fructose 1,6-bisphosphate (FBP).|||Belongs to the LDH/MDH superfamily. LDH family.|||Catalyzes the conversion of lactate to pyruvate.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS18810 ^@ http://purl.uniprot.org/uniprot/I0JSV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS10395 ^@ http://purl.uniprot.org/uniprot/I0JMV0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Hfq family.|||Homohexamer.|||RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. http://togogenome.org/gene/866895:HBHAL_RS17430 ^@ http://purl.uniprot.org/uniprot/I0JS18 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00470 ^@ http://purl.uniprot.org/uniprot/I0JH54 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS08100 ^@ http://purl.uniprot.org/uniprot/I0JLG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsuA/YedE (TC 9.B.102) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01940 ^@ http://purl.uniprot.org/uniprot/I0JHY0 ^@ Similarity ^@ Belongs to the diacylglycerol/lipid kinase family. http://togogenome.org/gene/866895:HBHAL_RS11405 ^@ http://purl.uniprot.org/uniprot/I0JNG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ScpB family.|||Cytoplasm|||Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.|||Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. http://togogenome.org/gene/866895:HBHAL_RS02275 ^@ http://purl.uniprot.org/uniprot/I0JI29 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 30 family. http://togogenome.org/gene/866895:HBHAL_RS04270 ^@ http://purl.uniprot.org/uniprot/I0JJA2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14165 ^@ http://purl.uniprot.org/uniprot/I0JQ24 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS15300 ^@ http://purl.uniprot.org/uniprot/I0JQQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gas vesicle GvpF/GvpL family.|||Gas vesicle|||Vesicle http://togogenome.org/gene/866895:HBHAL_RS03890 ^@ http://purl.uniprot.org/uniprot/I0JJ23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13080 ^@ http://purl.uniprot.org/uniprot/I0JPF3 ^@ Function|||Similarity ^@ Belongs to the uroporphyrinogen-III synthase family.|||Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. http://togogenome.org/gene/866895:HBHAL_RS05985 ^@ http://purl.uniprot.org/uniprot/I0JK77 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/866895:HBHAL_RS05505 ^@ http://purl.uniprot.org/uniprot/I0JJY2 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/866895:HBHAL_RS16685 ^@ http://purl.uniprot.org/uniprot/I0JRK3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family. http://togogenome.org/gene/866895:HBHAL_RS13645 ^@ http://purl.uniprot.org/uniprot/I0JPR5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS00050 ^@ http://purl.uniprot.org/uniprot/I0JGX7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/866895:HBHAL_RS06610 ^@ http://purl.uniprot.org/uniprot/I0JKK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13020 ^@ http://purl.uniprot.org/uniprot/I0JPE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/866895:HBHAL_RS15030 ^@ http://purl.uniprot.org/uniprot/I0JQJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum|||Belongs to the FliD family.|||Homopentamer.|||Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.|||Secreted http://togogenome.org/gene/866895:HBHAL_RS12865 ^@ http://purl.uniprot.org/uniprot/I0JPB0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/866895:HBHAL_RS11560 ^@ http://purl.uniprot.org/uniprot/I0JNJ4 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/866895:HBHAL_RS04230 ^@ http://purl.uniprot.org/uniprot/I0JJ94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09235 ^@ http://purl.uniprot.org/uniprot/I0JM59 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/866895:HBHAL_RS09050 ^@ http://purl.uniprot.org/uniprot/I0JM20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS02255 ^@ http://purl.uniprot.org/uniprot/I0JI25 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/866895:HBHAL_RS11370 ^@ http://purl.uniprot.org/uniprot/I0JNF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS08300 ^@ http://purl.uniprot.org/uniprot/I0JLK7 ^@ Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate. http://togogenome.org/gene/866895:HBHAL_RS00365 ^@ http://purl.uniprot.org/uniprot/I0JH34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/866895:HBHAL_RS09180 ^@ http://purl.uniprot.org/uniprot/I0JM48 ^@ Similarity ^@ Belongs to the transpeptidase family. http://togogenome.org/gene/866895:HBHAL_RS11965 ^@ http://purl.uniprot.org/uniprot/I0JNT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetokinase family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS02965 ^@ http://purl.uniprot.org/uniprot/I0JIH5 ^@ Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/866895:HBHAL_RS00400 ^@ http://purl.uniprot.org/uniprot/I0JQV5 ^@ Similarity ^@ Belongs to the transposase 11 family. http://togogenome.org/gene/866895:HBHAL_RS15350 ^@ http://purl.uniprot.org/uniprot/I0JQR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Homotetramer.|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/866895:HBHAL_RS00660 ^@ http://purl.uniprot.org/uniprot/I0JH78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/866895:HBHAL_RS18705 ^@ http://purl.uniprot.org/uniprot/I0JST4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/866895:HBHAL_RS14670 ^@ http://purl.uniprot.org/uniprot/I0JQC6 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS01390 ^@ http://purl.uniprot.org/uniprot/I0JHL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. TCR/Tet family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13535 ^@ http://purl.uniprot.org/uniprot/I0JPP2 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/866895:HBHAL_RS15520 ^@ http://purl.uniprot.org/uniprot/I0JQV2 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/866895:HBHAL_RS14000 ^@ http://purl.uniprot.org/uniprot/I0JPY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MenA family. Type 1 subfamily.|||Cell membrane|||Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).|||Membrane http://togogenome.org/gene/866895:HBHAL_RS04420 ^@ http://purl.uniprot.org/uniprot/I0JJD5 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/866895:HBHAL_RS04220 ^@ http://purl.uniprot.org/uniprot/I0JJ92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11865 ^@ http://purl.uniprot.org/uniprot/I0JNQ9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS17730 ^@ http://purl.uniprot.org/uniprot/I0JS82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS09740 ^@ http://purl.uniprot.org/uniprot/I0JMG6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS02020 ^@ http://purl.uniprot.org/uniprot/I0JHZ6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS04325 ^@ http://purl.uniprot.org/uniprot/I0JJB5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00100 ^@ http://purl.uniprot.org/uniprot/I0JGY6 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/866895:HBHAL_RS16455 ^@ http://purl.uniprot.org/uniprot/I0JRF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05675 ^@ http://purl.uniprot.org/uniprot/I0JK15 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. SigI subfamily.|||Cytoplasm|||Interacts with RsgI.|||Negatively regulated by the anti-sigma-I factor RsgI.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/866895:HBHAL_RS09570 ^@ http://purl.uniprot.org/uniprot/I0JMC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS04235 ^@ http://purl.uniprot.org/uniprot/I0JJ95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05235 ^@ http://purl.uniprot.org/uniprot/I0JJU7 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/866895:HBHAL_RS10160 ^@ http://purl.uniprot.org/uniprot/I0JMQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/866895:HBHAL_RS13090 ^@ http://purl.uniprot.org/uniprot/I0JPF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12605 ^@ http://purl.uniprot.org/uniprot/I0JP57 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/866895:HBHAL_RS14825 ^@ http://purl.uniprot.org/uniprot/I0JQF5 ^@ Function ^@ Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA. http://togogenome.org/gene/866895:HBHAL_RS08095 ^@ http://purl.uniprot.org/uniprot/I0JLG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS17455 ^@ http://purl.uniprot.org/uniprot/I0JS23 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/866895:HBHAL_RS09615 ^@ http://purl.uniprot.org/uniprot/I0JME0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/866895:HBHAL_RS19560 ^@ http://purl.uniprot.org/uniprot/I0JTA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase D family. Cardiolipin synthase subfamily.|||Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01420 ^@ http://purl.uniprot.org/uniprot/I0JHL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS04595 ^@ http://purl.uniprot.org/uniprot/I0JJH0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS06125 ^@ http://purl.uniprot.org/uniprot/I0JKA5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07215 ^@ http://purl.uniprot.org/uniprot/I0JKY6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS04945 ^@ http://purl.uniprot.org/uniprot/I0JJN7 ^@ Similarity ^@ Belongs to the bacterial reverse transcriptase family. http://togogenome.org/gene/866895:HBHAL_RS08130 ^@ http://purl.uniprot.org/uniprot/I0JLH1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates zinc uptake. May also transport other divalent cations.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14565 ^@ http://purl.uniprot.org/uniprot/I0JQA5 ^@ Function ^@ Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone. http://togogenome.org/gene/866895:HBHAL_RS08610 ^@ http://purl.uniprot.org/uniprot/I0JLS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13580 ^@ http://purl.uniprot.org/uniprot/I0JPQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0719 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00205 ^@ http://purl.uniprot.org/uniprot/I0JH06 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/866895:HBHAL_RS01035 ^@ http://purl.uniprot.org/uniprot/I0JHE0 ^@ Similarity ^@ Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family. http://togogenome.org/gene/866895:HBHAL_RS05655 ^@ http://purl.uniprot.org/uniprot/I0JK11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS08345 ^@ http://purl.uniprot.org/uniprot/I0JLL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS02905 ^@ http://purl.uniprot.org/uniprot/I0JIG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS15675 ^@ http://purl.uniprot.org/uniprot/I0JQY4 ^@ Function|||Similarity ^@ Belongs to the peptidase S51 family.|||Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides. http://togogenome.org/gene/866895:HBHAL_RS06920 ^@ http://purl.uniprot.org/uniprot/I0JKS3 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/866895:HBHAL_RS10880 ^@ http://purl.uniprot.org/uniprot/I0JN53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/866895:HBHAL_RS06580 ^@ http://purl.uniprot.org/uniprot/I0JKK1 ^@ Similarity ^@ Belongs to the truncated hemoglobin family. Group II subfamily. http://togogenome.org/gene/866895:HBHAL_RS05910 ^@ http://purl.uniprot.org/uniprot/I0JK61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS03045 ^@ http://purl.uniprot.org/uniprot/I0JIJ1 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/866895:HBHAL_RS12025 ^@ http://purl.uniprot.org/uniprot/I0JNU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/866895:HBHAL_RS19210 ^@ http://purl.uniprot.org/uniprot/I0JT37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Cell membrane|||Membrane|||Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. http://togogenome.org/gene/866895:HBHAL_RS17410 ^@ http://purl.uniprot.org/uniprot/I0JS14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/866895:HBHAL_RS08515 ^@ http://purl.uniprot.org/uniprot/I0JLQ2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase S45 family.|||Binds 1 Ca(2+) ion per dimer. http://togogenome.org/gene/866895:HBHAL_RS01325 ^@ http://purl.uniprot.org/uniprot/I0JHJ5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS09910 ^@ http://purl.uniprot.org/uniprot/I0JMK0 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/866895:HBHAL_RS08285 ^@ http://purl.uniprot.org/uniprot/I0JLK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00785 ^@ http://purl.uniprot.org/uniprot/I0JHA3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/866895:HBHAL_RS19015 ^@ http://purl.uniprot.org/uniprot/I0JSZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prokaryotic Ku family.|||Homodimer. Interacts with LigD.|||With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. http://togogenome.org/gene/866895:HBHAL_RS15125 ^@ http://purl.uniprot.org/uniprot/I0JQL9 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/866895:HBHAL_RS09835 ^@ http://purl.uniprot.org/uniprot/I0JMI5 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/866895:HBHAL_RS10795 ^@ http://purl.uniprot.org/uniprot/I0JN35 ^@ Caution|||Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Belongs to the MsrB Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS12565 ^@ http://purl.uniprot.org/uniprot/I0JP49 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/866895:HBHAL_RS06835 ^@ http://purl.uniprot.org/uniprot/I0JKQ7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/866895:HBHAL_RS09840 ^@ http://purl.uniprot.org/uniprot/I0JMI6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/866895:HBHAL_RS11655 ^@ http://purl.uniprot.org/uniprot/I0JNL2 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/866895:HBHAL_RS06840 ^@ http://purl.uniprot.org/uniprot/I0JKQ8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS11570 ^@ http://purl.uniprot.org/uniprot/I0JNJ6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/866895:HBHAL_RS13430 ^@ http://purl.uniprot.org/uniprot/I0JPM1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/866895:HBHAL_RS18755 ^@ http://purl.uniprot.org/uniprot/I0JSU4 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/866895:HBHAL_RS00730 ^@ http://purl.uniprot.org/uniprot/I0JH92 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS12895 ^@ http://purl.uniprot.org/uniprot/I0JPB6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/866895:HBHAL_RS09285 ^@ http://purl.uniprot.org/uniprot/I0JM71 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/866895:HBHAL_RS19255 ^@ http://purl.uniprot.org/uniprot/I0JT48 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/866895:HBHAL_RS14540 ^@ http://purl.uniprot.org/uniprot/I0JQA0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS10930 ^@ http://purl.uniprot.org/uniprot/I0JN64 ^@ Similarity ^@ Belongs to the UPF0398 family. http://togogenome.org/gene/866895:HBHAL_RS16885 ^@ http://purl.uniprot.org/uniprot/I0JRQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12570 ^@ http://purl.uniprot.org/uniprot/I0JP50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/866895:HBHAL_RS15765 ^@ http://purl.uniprot.org/uniprot/I0JR02 ^@ PTM|||Similarity|||Subunit ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaved by autocatalysis into a large and a small subunit.|||This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide. http://togogenome.org/gene/866895:HBHAL_RS00340 ^@ http://purl.uniprot.org/uniprot/I0JH29 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/866895:HBHAL_RS05065 ^@ http://purl.uniprot.org/uniprot/I0JJR5 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/866895:HBHAL_RS17360 ^@ http://purl.uniprot.org/uniprot/I0JS04 ^@ Similarity ^@ Belongs to the flagella basal body rod proteins family. http://togogenome.org/gene/866895:HBHAL_RS06975 ^@ http://purl.uniprot.org/uniprot/I0JKT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS17935 ^@ http://purl.uniprot.org/uniprot/I0JSC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VirD4/TraG family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS03785 ^@ http://purl.uniprot.org/uniprot/I0JIZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05850 ^@ http://purl.uniprot.org/uniprot/I0JK49 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/866895:HBHAL_RS05010 ^@ http://purl.uniprot.org/uniprot/I0JJQ4 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS17440 ^@ http://purl.uniprot.org/uniprot/I0JS20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13445 ^@ http://purl.uniprot.org/uniprot/I0JPM4 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS01715 ^@ http://purl.uniprot.org/uniprot/I0JHT5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS09750 ^@ http://purl.uniprot.org/uniprot/I0JMG9 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS01485 ^@ http://purl.uniprot.org/uniprot/I0JHN4 ^@ Similarity ^@ Belongs to the cysteine dioxygenase family. http://togogenome.org/gene/866895:HBHAL_RS02285 ^@ http://purl.uniprot.org/uniprot/I0JI31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GerABKA family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07280 ^@ http://purl.uniprot.org/uniprot/I0JL00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS17555 ^@ http://purl.uniprot.org/uniprot/I0JS47 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/866895:HBHAL_RS00815 ^@ http://purl.uniprot.org/uniprot/I0JHA9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/866895:HBHAL_RS03080 ^@ http://purl.uniprot.org/uniprot/I0JIJ8 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/866895:HBHAL_RS07205 ^@ http://purl.uniprot.org/uniprot/I0JKY4 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/866895:HBHAL_RS03885 ^@ http://purl.uniprot.org/uniprot/I0JJ22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07140 ^@ http://purl.uniprot.org/uniprot/I0JKX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12450 ^@ http://purl.uniprot.org/uniprot/I0JP23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/866895:HBHAL_RS09355 ^@ http://purl.uniprot.org/uniprot/I0JM85 ^@ Similarity ^@ Belongs to the RemA family. http://togogenome.org/gene/866895:HBHAL_RS15475 ^@ http://purl.uniprot.org/uniprot/I0JQU2 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/866895:HBHAL_RS09385 ^@ http://purl.uniprot.org/uniprot/I0JM91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Cytoplasm|||Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. http://togogenome.org/gene/866895:HBHAL_RS04700 ^@ http://purl.uniprot.org/uniprot/I0JJJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M4 family.|||Extracellular zinc metalloprotease.|||Secreted http://togogenome.org/gene/866895:HBHAL_RS13675 ^@ http://purl.uniprot.org/uniprot/I0JPS1 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/866895:HBHAL_RS08935 ^@ http://purl.uniprot.org/uniprot/I0JLZ6 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-I family. http://togogenome.org/gene/866895:HBHAL_RS04785 ^@ http://purl.uniprot.org/uniprot/I0JJK7 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/866895:HBHAL_RS13115 ^@ http://purl.uniprot.org/uniprot/I0JPG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01500 ^@ http://purl.uniprot.org/uniprot/I0JHN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0324 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS19095 ^@ http://purl.uniprot.org/uniprot/I0JT13 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/866895:HBHAL_RS18345 ^@ http://purl.uniprot.org/uniprot/I0JSK6 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/866895:HBHAL_RS11495 ^@ http://purl.uniprot.org/uniprot/I0JNI1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/866895:HBHAL_RS11330 ^@ http://purl.uniprot.org/uniprot/I0JNE6 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/866895:HBHAL_RS18195 ^@ http://purl.uniprot.org/uniprot/I0JSH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the branched chain amino acid transporter family.|||Cell membrane|||Component of the transport system for branched-chain amino acids.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12765 ^@ http://purl.uniprot.org/uniprot/I0JP90 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS10500 ^@ http://purl.uniprot.org/uniprot/I0JMX4 ^@ Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tlp family.|||Expressed only in the forespore compartment of sporulating cells.|||Spore core http://togogenome.org/gene/866895:HBHAL_RS01355 ^@ http://purl.uniprot.org/uniprot/I0JHK1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 3 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS18785 ^@ http://purl.uniprot.org/uniprot/I0JSV1 ^@ Similarity ^@ Belongs to the CarB family. http://togogenome.org/gene/866895:HBHAL_RS10850 ^@ http://purl.uniprot.org/uniprot/I0JN46 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/866895:HBHAL_RS09200 ^@ http://purl.uniprot.org/uniprot/I0JM52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05635 ^@ http://purl.uniprot.org/uniprot/I0JK07 ^@ Similarity ^@ Belongs to the GerABKC lipoprotein family. http://togogenome.org/gene/866895:HBHAL_RS13460 ^@ http://purl.uniprot.org/uniprot/I0JPM7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS13450 ^@ http://purl.uniprot.org/uniprot/I0JPM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS03090 ^@ http://purl.uniprot.org/uniprot/I0JIK0 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/866895:HBHAL_RS01030 ^@ http://purl.uniprot.org/uniprot/I0JHD9 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/866895:HBHAL_RS02615 ^@ http://purl.uniprot.org/uniprot/I0JIA1 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/866895:HBHAL_RS03170 ^@ http://purl.uniprot.org/uniprot/I0JIL7 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/866895:HBHAL_RS19300 ^@ http://purl.uniprot.org/uniprot/I0JT56 ^@ Similarity ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. http://togogenome.org/gene/866895:HBHAL_RS19775 ^@ http://purl.uniprot.org/uniprot/I0JTF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14815 ^@ http://purl.uniprot.org/uniprot/I0JQF3 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subunit ^@ Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).|||Belongs to the FGGY kinase family.|||Homotetramer and homodimer (in equilibrium).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme. http://togogenome.org/gene/866895:HBHAL_RS08185 ^@ http://purl.uniprot.org/uniprot/I0JLI1 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS13855 ^@ http://purl.uniprot.org/uniprot/I0JPV9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08480 ^@ http://purl.uniprot.org/uniprot/I0JLP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/866895:HBHAL_RS17535 ^@ http://purl.uniprot.org/uniprot/I0JS42 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS09335 ^@ http://purl.uniprot.org/uniprot/I0JM81 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS15525 ^@ http://purl.uniprot.org/uniprot/I0JQV3 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/866895:HBHAL_RS04205 ^@ http://purl.uniprot.org/uniprot/I0JJ89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS19000 ^@ http://purl.uniprot.org/uniprot/I0JSZ5 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/866895:HBHAL_RS03755 ^@ http://purl.uniprot.org/uniprot/I0JIZ2 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/866895:HBHAL_RS18710 ^@ http://purl.uniprot.org/uniprot/I0JST5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/866895:HBHAL_RS10750 ^@ http://purl.uniprot.org/uniprot/I0JN26 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS19220 ^@ http://purl.uniprot.org/uniprot/I0JT40 ^@ Similarity ^@ Belongs to the aspartate/glutamate racemases family. http://togogenome.org/gene/866895:HBHAL_RS17460 ^@ http://purl.uniprot.org/uniprot/I0JS24 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/866895:HBHAL_RS00485 ^@ http://purl.uniprot.org/uniprot/I0JH57 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/866895:HBHAL_RS03715 ^@ http://purl.uniprot.org/uniprot/I0JIY4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS15115 ^@ http://purl.uniprot.org/uniprot/I0JQL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS14225 ^@ http://purl.uniprot.org/uniprot/I0JQ36 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/866895:HBHAL_RS07820 ^@ http://purl.uniprot.org/uniprot/I0JLA1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/866895:HBHAL_RS14970 ^@ http://purl.uniprot.org/uniprot/I0JQI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/866895:HBHAL_RS15505 ^@ http://purl.uniprot.org/uniprot/I0JQU9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS09160 ^@ http://purl.uniprot.org/uniprot/I0JM44 ^@ Function|||Similarity ^@ Belongs to the BshC family.|||Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH. http://togogenome.org/gene/866895:HBHAL_RS03260 ^@ http://purl.uniprot.org/uniprot/I0JIN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VirD4/TraG family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS17655 ^@ http://purl.uniprot.org/uniprot/I0JS67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer. http://togogenome.org/gene/866895:HBHAL_RS13110 ^@ http://purl.uniprot.org/uniprot/I0JPF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09595 ^@ http://purl.uniprot.org/uniprot/I0JMD5 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily. http://togogenome.org/gene/866895:HBHAL_RS17810 ^@ http://purl.uniprot.org/uniprot/I0JS96 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/866895:HBHAL_RS15500 ^@ http://purl.uniprot.org/uniprot/I0JQU8 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase subunit A family. http://togogenome.org/gene/866895:HBHAL_RS01290 ^@ http://purl.uniprot.org/uniprot/I0JHI9 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS17805 ^@ http://purl.uniprot.org/uniprot/I0JS95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.|||Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers. http://togogenome.org/gene/866895:HBHAL_RS00065 ^@ http://purl.uniprot.org/uniprot/I0JGY0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/866895:HBHAL_RS04250 ^@ http://purl.uniprot.org/uniprot/I0JJ98 ^@ Cofactor|||Similarity ^@ Belongs to the Fur family.|||Binds 1 Mn(2+) or Fe(2+) ion per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/866895:HBHAL_RS08190 ^@ http://purl.uniprot.org/uniprot/I0JLI2 ^@ Similarity ^@ Belongs to the AlaDH/PNT family. http://togogenome.org/gene/866895:HBHAL_RS06665 ^@ http://purl.uniprot.org/uniprot/I0JKM2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/866895:HBHAL_RS08895 ^@ http://purl.uniprot.org/uniprot/I0JLY6 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/866895:HBHAL_RS02185 ^@ http://purl.uniprot.org/uniprot/I0JI12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS04305 ^@ http://purl.uniprot.org/uniprot/I0JJB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS01115 ^@ http://purl.uniprot.org/uniprot/I0JHF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS03640 ^@ http://purl.uniprot.org/uniprot/I0JIW9 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS03945 ^@ http://purl.uniprot.org/uniprot/I0JJ33 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS01515 ^@ http://purl.uniprot.org/uniprot/I0JHP2 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/866895:HBHAL_RS05120 ^@ http://purl.uniprot.org/uniprot/I0JJS5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/866895:HBHAL_RS14285 ^@ http://purl.uniprot.org/uniprot/I0JQ49 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/866895:HBHAL_RS14930 ^@ http://purl.uniprot.org/uniprot/I0JQH7 ^@ Similarity ^@ Belongs to the CapA family. http://togogenome.org/gene/866895:HBHAL_RS06440 ^@ http://purl.uniprot.org/uniprot/I0JKH2 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/866895:HBHAL_RS13105 ^@ http://purl.uniprot.org/uniprot/I0JPF8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/866895:HBHAL_RS00075 ^@ http://purl.uniprot.org/uniprot/I0JGY2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/866895:HBHAL_RS10545 ^@ http://purl.uniprot.org/uniprot/I0JMY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||In the C-terminal section; belongs to the OsmX family.|||In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS11105 ^@ http://purl.uniprot.org/uniprot/I0JNA1 ^@ Similarity ^@ Belongs to the prephenate/arogenate dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS17450 ^@ http://purl.uniprot.org/uniprot/I0JS22 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/866895:HBHAL_RS13695 ^@ http://purl.uniprot.org/uniprot/I0JPS5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/866895:HBHAL_RS01165 ^@ http://purl.uniprot.org/uniprot/I0JHG5 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS04295 ^@ http://purl.uniprot.org/uniprot/I0JJA7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS02955 ^@ http://purl.uniprot.org/uniprot/I0JIH3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS19800 ^@ http://purl.uniprot.org/uniprot/I0JTF7 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/866895:HBHAL_RS00715 ^@ http://purl.uniprot.org/uniprot/I0JH89 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/866895:HBHAL_RS15270 ^@ http://purl.uniprot.org/uniprot/I0JQP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00800 ^@ http://purl.uniprot.org/uniprot/I0JHA6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/866895:HBHAL_RS08735 ^@ http://purl.uniprot.org/uniprot/I0JLV2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS08810 ^@ http://purl.uniprot.org/uniprot/I0JLW9 ^@ Function|||Similarity ^@ Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.|||Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. http://togogenome.org/gene/866895:HBHAL_RS11265 ^@ http://purl.uniprot.org/uniprot/I0JND4 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/866895:HBHAL_RS13570 ^@ http://purl.uniprot.org/uniprot/I0JPP9 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/866895:HBHAL_RS17425 ^@ http://purl.uniprot.org/uniprot/I0JS17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS02875 ^@ http://purl.uniprot.org/uniprot/I0JIF6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS01410 ^@ http://purl.uniprot.org/uniprot/I0JHL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS13945 ^@ http://purl.uniprot.org/uniprot/I0JPX6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/866895:HBHAL_RS09850 ^@ http://purl.uniprot.org/uniprot/I0JMI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/866895:HBHAL_RS02705 ^@ http://purl.uniprot.org/uniprot/I0JIC1 ^@ Function|||Similarity ^@ Belongs to the acetyltransferase family. EctA subfamily.|||Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. http://togogenome.org/gene/866895:HBHAL_RS01670 ^@ http://purl.uniprot.org/uniprot/I0JHS7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/866895:HBHAL_RS14900 ^@ http://purl.uniprot.org/uniprot/I0JQH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.|||Cytoplasm|||Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. http://togogenome.org/gene/866895:HBHAL_RS11905 ^@ http://purl.uniprot.org/uniprot/I0JNR8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/866895:HBHAL_RS03165 ^@ http://purl.uniprot.org/uniprot/I0JIL6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/866895:HBHAL_RS16530 ^@ http://purl.uniprot.org/uniprot/I0JRH2 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00885 ^@ http://purl.uniprot.org/uniprot/I0JHC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS15225 ^@ http://purl.uniprot.org/uniprot/I0JQN8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/866895:HBHAL_RS04680 ^@ http://purl.uniprot.org/uniprot/I0JJI7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS00880 ^@ http://purl.uniprot.org/uniprot/I0JHC2 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/866895:HBHAL_RS02680 ^@ http://purl.uniprot.org/uniprot/I0JIB5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/866895:HBHAL_RS10105 ^@ http://purl.uniprot.org/uniprot/I0JMP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS05240 ^@ http://purl.uniprot.org/uniprot/I0JJU8 ^@ Similarity ^@ Belongs to the gamma-type SASP family. http://togogenome.org/gene/866895:HBHAL_RS13765 ^@ http://purl.uniprot.org/uniprot/I0JPT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS10135 ^@ http://purl.uniprot.org/uniprot/I0JMP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14610 ^@ http://purl.uniprot.org/uniprot/I0JQB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13240 ^@ http://purl.uniprot.org/uniprot/I0JPH9 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/866895:HBHAL_RS17290 ^@ http://purl.uniprot.org/uniprot/I0JRZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS00860 ^@ http://purl.uniprot.org/uniprot/I0JHB8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/866895:HBHAL_RS17235 ^@ http://purl.uniprot.org/uniprot/I0JRX9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/866895:HBHAL_RS20160 ^@ http://purl.uniprot.org/uniprot/I0JTM9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of guanine in position 535 of 16S rRNA. http://togogenome.org/gene/866895:HBHAL_RS13725 ^@ http://purl.uniprot.org/uniprot/I0JPT1 ^@ Similarity ^@ Belongs to the histone deacetylase family. http://togogenome.org/gene/866895:HBHAL_RS12710 ^@ http://purl.uniprot.org/uniprot/I0JP79 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/866895:HBHAL_RS10435 ^@ http://purl.uniprot.org/uniprot/I0JMV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/866895:HBHAL_RS10420 ^@ http://purl.uniprot.org/uniprot/I0JMV5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/866895:HBHAL_RS16170 ^@ http://purl.uniprot.org/uniprot/I0JR90 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.|||Cytoplasm|||Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.|||Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/866895:HBHAL_RS11500 ^@ http://purl.uniprot.org/uniprot/I0JNI2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/866895:HBHAL_RS12215 ^@ http://purl.uniprot.org/uniprot/I0JNY2 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/866895:HBHAL_RS09900 ^@ http://purl.uniprot.org/uniprot/I0JMJ8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/866895:HBHAL_RS14060 ^@ http://purl.uniprot.org/uniprot/I0JQ01 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/866895:HBHAL_RS14260 ^@ http://purl.uniprot.org/uniprot/I0JQ44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS04715 ^@ http://purl.uniprot.org/uniprot/I0JJJ3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/866895:HBHAL_RS06805 ^@ http://purl.uniprot.org/uniprot/I0JKQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS08205 ^@ http://purl.uniprot.org/uniprot/I0JLI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS12720 ^@ http://purl.uniprot.org/uniprot/I0JP81 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.|||Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. http://togogenome.org/gene/866895:HBHAL_RS16195 ^@ http://purl.uniprot.org/uniprot/I0JR96 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease gamma subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/866895:HBHAL_RS12760 ^@ http://purl.uniprot.org/uniprot/I0JP89 ^@ Similarity ^@ Belongs to the UPF0297 family. http://togogenome.org/gene/866895:HBHAL_RS11120 ^@ http://purl.uniprot.org/uniprot/I0JNA4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS18455 ^@ http://purl.uniprot.org/uniprot/I0JSN0 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/866895:HBHAL_RS02415 ^@ http://purl.uniprot.org/uniprot/I0JI56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Cytoplasm|||Homodimer.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/866895:HBHAL_RS09185 ^@ http://purl.uniprot.org/uniprot/I0JM49 ^@ Similarity ^@ Belongs to the transpeptidase family. http://togogenome.org/gene/866895:HBHAL_RS04645 ^@ http://purl.uniprot.org/uniprot/I0JJI0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS19850 ^@ http://purl.uniprot.org/uniprot/I0JTG7 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/866895:HBHAL_RS15050 ^@ http://purl.uniprot.org/uniprot/I0JQK4 ^@ Similarity ^@ Belongs to the bacterial flagellin family. http://togogenome.org/gene/866895:HBHAL_RS04705 ^@ http://purl.uniprot.org/uniprot/I0JJJ2 ^@ Similarity ^@ Belongs to the manganese catalase family. http://togogenome.org/gene/866895:HBHAL_RS17510 ^@ http://purl.uniprot.org/uniprot/I0JS35 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/866895:HBHAL_RS19950 ^@ http://purl.uniprot.org/uniprot/I0JTI8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/866895:HBHAL_RS18155 ^@ http://purl.uniprot.org/uniprot/I0JSG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06895 ^@ http://purl.uniprot.org/uniprot/I0JKR8 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS05705 ^@ http://purl.uniprot.org/uniprot/I0JK21 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS09220 ^@ http://purl.uniprot.org/uniprot/I0JM56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/866895:HBHAL_RS17420 ^@ http://purl.uniprot.org/uniprot/I0JS16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/866895:HBHAL_RS17820 ^@ http://purl.uniprot.org/uniprot/I0JS98 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/866895:HBHAL_RS17840 ^@ http://purl.uniprot.org/uniprot/I0JSA3 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/866895:HBHAL_RS12185 ^@ http://purl.uniprot.org/uniprot/I0JNX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/866895:HBHAL_RS19885 ^@ http://purl.uniprot.org/uniprot/I0JTH6 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/866895:HBHAL_RS10640 ^@ http://purl.uniprot.org/uniprot/I0JN03 ^@ Similarity ^@ Belongs to the nitroreductase family. http://togogenome.org/gene/866895:HBHAL_RS11945 ^@ http://purl.uniprot.org/uniprot/I0JNS8 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS03060 ^@ http://purl.uniprot.org/uniprot/I0JIJ4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/866895:HBHAL_RS10175 ^@ http://purl.uniprot.org/uniprot/I0JMQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/866895:HBHAL_RS14790 ^@ http://purl.uniprot.org/uniprot/I0JQE8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS12645 ^@ http://purl.uniprot.org/uniprot/I0JP65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein uL14 (rplN). http://togogenome.org/gene/866895:HBHAL_RS09100 ^@ http://purl.uniprot.org/uniprot/I0JM31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/866895:HBHAL_RS06865 ^@ http://purl.uniprot.org/uniprot/I0JKR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/866895:HBHAL_RS01875 ^@ http://purl.uniprot.org/uniprot/I0JHW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08560 ^@ http://purl.uniprot.org/uniprot/I0JLR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS19290 ^@ http://purl.uniprot.org/uniprot/I0JT54 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family.|||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. http://togogenome.org/gene/866895:HBHAL_RS12770 ^@ http://purl.uniprot.org/uniprot/I0JP91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00835 ^@ http://purl.uniprot.org/uniprot/I0JHB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/866895:HBHAL_RS15040 ^@ http://purl.uniprot.org/uniprot/I0JQK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.|||Belongs to the FliW family.|||Cytoplasm|||Interacts with translational regulator CsrA and flagellin(s). http://togogenome.org/gene/866895:HBHAL_RS17795 ^@ http://purl.uniprot.org/uniprot/I0JS94 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/866895:HBHAL_RS12730 ^@ http://purl.uniprot.org/uniprot/I0JP83 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/866895:HBHAL_RS11470 ^@ http://purl.uniprot.org/uniprot/I0JNH5 ^@ Similarity ^@ Belongs to the sigma-70 factor family. http://togogenome.org/gene/866895:HBHAL_RS09250 ^@ http://purl.uniprot.org/uniprot/I0JM63 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/866895:HBHAL_RS13600 ^@ http://purl.uniprot.org/uniprot/I0JPQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS00845 ^@ http://purl.uniprot.org/uniprot/I0JHB5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/866895:HBHAL_RS04600 ^@ http://purl.uniprot.org/uniprot/I0JJH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS05765 ^@ http://purl.uniprot.org/uniprot/I0JK33 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS12075 ^@ http://purl.uniprot.org/uniprot/I0JNV4 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/866895:HBHAL_RS02180 ^@ http://purl.uniprot.org/uniprot/I0JI11 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/866895:HBHAL_RS18220 ^@ http://purl.uniprot.org/uniprot/I0JSH8 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/866895:HBHAL_RS02215 ^@ http://purl.uniprot.org/uniprot/I0JI18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/866895:HBHAL_RS14955 ^@ http://purl.uniprot.org/uniprot/I0JQI4 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/866895:HBHAL_RS09470 ^@ http://purl.uniprot.org/uniprot/I0JMA8 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/866895:HBHAL_RS15090 ^@ http://purl.uniprot.org/uniprot/I0JQL2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS13175 ^@ http://purl.uniprot.org/uniprot/I0JPH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09805 ^@ http://purl.uniprot.org/uniprot/I0JMH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS12320 ^@ http://purl.uniprot.org/uniprot/I0JP04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/866895:HBHAL_RS11860 ^@ http://purl.uniprot.org/uniprot/I0JNQ8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/866895:HBHAL_RS09945 ^@ http://purl.uniprot.org/uniprot/I0JMK7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial flagellum basal body|||Belongs to the flagella basal body rod proteins family.|||The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. http://togogenome.org/gene/866895:HBHAL_RS11825 ^@ http://purl.uniprot.org/uniprot/I0JNQ0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/866895:HBHAL_RS06850 ^@ http://purl.uniprot.org/uniprot/I0JKR0 ^@ Similarity ^@ Belongs to the extradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/866895:HBHAL_RS13345 ^@ http://purl.uniprot.org/uniprot/I0JPK2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family. RnhC subfamily.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/866895:HBHAL_RS13620 ^@ http://purl.uniprot.org/uniprot/I0JPR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS01815 ^@ http://purl.uniprot.org/uniprot/I0JHV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS10675 ^@ http://purl.uniprot.org/uniprot/I0JN11 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/866895:HBHAL_RS10740 ^@ http://purl.uniprot.org/uniprot/I0JN24 ^@ Similarity ^@ Belongs to the peptidase S58 family. http://togogenome.org/gene/866895:HBHAL_RS19835 ^@ http://purl.uniprot.org/uniprot/I0JTG4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11135 ^@ http://purl.uniprot.org/uniprot/I0JNA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/866895:HBHAL_RS15480 ^@ http://purl.uniprot.org/uniprot/I0JQU3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/866895:HBHAL_RS16645 ^@ http://purl.uniprot.org/uniprot/I0JRJ5 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS00780 ^@ http://purl.uniprot.org/uniprot/I0JHA2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS13305 ^@ http://purl.uniprot.org/uniprot/I0JPJ3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/866895:HBHAL_RS17110 ^@ http://purl.uniprot.org/uniprot/I0JRV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00770 ^@ http://purl.uniprot.org/uniprot/I0JHA0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/866895:HBHAL_RS14850 ^@ http://purl.uniprot.org/uniprot/I0JQG0 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HPrK/P family.|||Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.|||Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue. Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.|||Homohexamer.|||The Walker A ATP-binding motif also binds Pi and PPi. http://togogenome.org/gene/866895:HBHAL_RS00905 ^@ http://purl.uniprot.org/uniprot/I0JHC7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/866895:HBHAL_RS18110 ^@ http://purl.uniprot.org/uniprot/I0JSF5 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/866895:HBHAL_RS00910 ^@ http://purl.uniprot.org/uniprot/I0JHC8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/866895:HBHAL_RS04390 ^@ http://purl.uniprot.org/uniprot/I0JJC9 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. http://togogenome.org/gene/866895:HBHAL_RS06015 ^@ http://purl.uniprot.org/uniprot/I0JK83 ^@ Similarity ^@ Belongs to the GbsR family. http://togogenome.org/gene/866895:HBHAL_RS16985 ^@ http://purl.uniprot.org/uniprot/I0JRS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06000 ^@ http://purl.uniprot.org/uniprot/I0JK80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12340 ^@ http://purl.uniprot.org/uniprot/I0JP08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PstS family.|||Cell membrane|||Involved in the system for phosphate transport across the cytoplasmic membrane.|||Membrane|||Part of the ABC transporter complex PstSACB involved in phosphate import.|||The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS). http://togogenome.org/gene/866895:HBHAL_RS20030 ^@ http://purl.uniprot.org/uniprot/I0JTK3 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity ^@ Belongs to the globin family. Two-domain flavohemoproteins subfamily.|||Binds 1 FAD per subunit.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Consists of two distinct domains; an N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS12490 ^@ http://purl.uniprot.org/uniprot/I0JP34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS07115 ^@ http://purl.uniprot.org/uniprot/I0JKW4 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family. http://togogenome.org/gene/866895:HBHAL_RS11480 ^@ http://purl.uniprot.org/uniprot/I0JNH7 ^@ Function|||Similarity ^@ Belongs to the anti-sigma-factor antagonist family.|||In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition. http://togogenome.org/gene/866895:HBHAL_RS10120 ^@ http://purl.uniprot.org/uniprot/I0JMP5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS08485 ^@ http://purl.uniprot.org/uniprot/I0JLP6 ^@ Similarity ^@ In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family. http://togogenome.org/gene/866895:HBHAL_RS14665 ^@ http://purl.uniprot.org/uniprot/I0JQC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/866895:HBHAL_RS01305 ^@ http://purl.uniprot.org/uniprot/I0JHJ1 ^@ Similarity|||Subunit ^@ Belongs to the glutaminase family.|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS13370 ^@ http://purl.uniprot.org/uniprot/I0JPK7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/866895:HBHAL_RS01385 ^@ http://purl.uniprot.org/uniprot/I0JHK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08710 ^@ http://purl.uniprot.org/uniprot/I0JLU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS19810 ^@ http://purl.uniprot.org/uniprot/I0JTF9 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/866895:HBHAL_RS18555 ^@ http://purl.uniprot.org/uniprot/I0JSQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS09020 ^@ http://purl.uniprot.org/uniprot/I0JM14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Cell membrane|||Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08680 ^@ http://purl.uniprot.org/uniprot/I0JLT9 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/866895:HBHAL_RS16165 ^@ http://purl.uniprot.org/uniprot/I0JR89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UreD family.|||Cytoplasm|||Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.|||UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/866895:HBHAL_RS19985 ^@ http://purl.uniprot.org/uniprot/I0JTJ6 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/866895:HBHAL_RS01160 ^@ http://purl.uniprot.org/uniprot/I0JHG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS11250 ^@ http://purl.uniprot.org/uniprot/I0JND0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protease PrsW family.|||Cell membrane|||Involved in the degradation of specific anti-sigma factors.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS01200 ^@ http://purl.uniprot.org/uniprot/I0JHH1 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/866895:HBHAL_RS05200 ^@ http://purl.uniprot.org/uniprot/I0JJU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HPr family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. http://togogenome.org/gene/866895:HBHAL_RS08240 ^@ http://purl.uniprot.org/uniprot/I0JLJ3 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/866895:HBHAL_RS15610 ^@ http://purl.uniprot.org/uniprot/I0JQX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M4 family.|||Extracellular zinc metalloprotease.|||Secreted http://togogenome.org/gene/866895:HBHAL_RS09960 ^@ http://purl.uniprot.org/uniprot/I0JML0 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliG family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16960 ^@ http://purl.uniprot.org/uniprot/I0JRS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS03705 ^@ http://purl.uniprot.org/uniprot/I0JIY2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/866895:HBHAL_RS02780 ^@ http://purl.uniprot.org/uniprot/I0JID8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS10530 ^@ http://purl.uniprot.org/uniprot/I0JMY0 ^@ Function|||Similarity ^@ Belongs to the GTP cyclohydrolase IV family.|||Converts GTP to 7,8-dihydroneopterin triphosphate. http://togogenome.org/gene/866895:HBHAL_RS16900 ^@ http://purl.uniprot.org/uniprot/I0JRQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS17065 ^@ http://purl.uniprot.org/uniprot/I0JRU5 ^@ Cofactor|||Function ^@ Binds 2 [4Fe-4S] clusters.|||Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. http://togogenome.org/gene/866895:HBHAL_RS05915 ^@ http://purl.uniprot.org/uniprot/I0JK62 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/866895:HBHAL_RS05560 ^@ http://purl.uniprot.org/uniprot/I0JJZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09875 ^@ http://purl.uniprot.org/uniprot/I0JMJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS02195 ^@ http://purl.uniprot.org/uniprot/I0JI14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acetylates the N-terminal alanine of ribosomal protein bS18.|||Belongs to the acetyltransferase family. RimI subfamily.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS03035 ^@ http://purl.uniprot.org/uniprot/I0JII9 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/866895:HBHAL_RS17435 ^@ http://purl.uniprot.org/uniprot/I0JS19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12800 ^@ http://purl.uniprot.org/uniprot/I0JP96 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS07925 ^@ http://purl.uniprot.org/uniprot/I0JLC8 ^@ Similarity ^@ Belongs to the FBPase class 3 family. http://togogenome.org/gene/866895:HBHAL_RS19260 ^@ http://purl.uniprot.org/uniprot/I0JT49 ^@ Similarity ^@ Belongs to the peptidase S58 family. http://togogenome.org/gene/866895:HBHAL_RS06575 ^@ http://purl.uniprot.org/uniprot/I0JKK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP.|||Belongs to the SpxH family.|||Cytoplasm|||Interacts with Spx. http://togogenome.org/gene/866895:HBHAL_RS12680 ^@ http://purl.uniprot.org/uniprot/I0JP73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07275 ^@ http://purl.uniprot.org/uniprot/I0JKZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS08070 ^@ http://purl.uniprot.org/uniprot/I0JLF9 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/866895:HBHAL_RS12455 ^@ http://purl.uniprot.org/uniprot/I0JP24 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/866895:HBHAL_RS16610 ^@ http://purl.uniprot.org/uniprot/I0JRI8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS10915 ^@ http://purl.uniprot.org/uniprot/I0JN61 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/866895:HBHAL_RS15700 ^@ http://purl.uniprot.org/uniprot/I0JQY9 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/866895:HBHAL_RS07885 ^@ http://purl.uniprot.org/uniprot/I0JLC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS14915 ^@ http://purl.uniprot.org/uniprot/I0JQH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS20295 ^@ http://purl.uniprot.org/uniprot/I0JTP7 ^@ Similarity ^@ Belongs to the Gram-positive plasmids replication protein type 1 family. http://togogenome.org/gene/866895:HBHAL_RS07125 ^@ http://purl.uniprot.org/uniprot/I0JKW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LTA synthase family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00765 ^@ http://purl.uniprot.org/uniprot/I0JH99 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/866895:HBHAL_RS03385 ^@ http://purl.uniprot.org/uniprot/I0JIR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS00870 ^@ http://purl.uniprot.org/uniprot/I0JHC0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/866895:HBHAL_RS07750 ^@ http://purl.uniprot.org/uniprot/I0JL88 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/866895:HBHAL_RS01145 ^@ http://purl.uniprot.org/uniprot/I0JHG1 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/866895:HBHAL_RS09295 ^@ http://purl.uniprot.org/uniprot/I0JM73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS15535 ^@ http://purl.uniprot.org/uniprot/I0JQV5 ^@ Similarity ^@ Belongs to the transposase 11 family. http://togogenome.org/gene/866895:HBHAL_RS13285 ^@ http://purl.uniprot.org/uniprot/I0JPI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/866895:HBHAL_RS10145 ^@ http://purl.uniprot.org/uniprot/I0JMQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-C family. PolC subfamily.|||Cytoplasm|||Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/866895:HBHAL_RS14655 ^@ http://purl.uniprot.org/uniprot/I0JQC3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/866895:HBHAL_RS00150 ^@ http://purl.uniprot.org/uniprot/I0JGZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS08840 ^@ http://purl.uniprot.org/uniprot/I0JLX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS05195 ^@ http://purl.uniprot.org/uniprot/I0JJT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS17635 ^@ http://purl.uniprot.org/uniprot/I0JS63 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS02010 ^@ http://purl.uniprot.org/uniprot/I0JHZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12560 ^@ http://purl.uniprot.org/uniprot/I0JP48 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/866895:HBHAL_RS14230 ^@ http://purl.uniprot.org/uniprot/I0JQ37 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/866895:HBHAL_RS18145 ^@ http://purl.uniprot.org/uniprot/I0JSG2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/866895:HBHAL_RS19415 ^@ http://purl.uniprot.org/uniprot/I0JT78 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS13985 ^@ http://purl.uniprot.org/uniprot/I0JPY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily. MenH family.|||Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS16625 ^@ http://purl.uniprot.org/uniprot/I0JRJ1 ^@ Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate. http://togogenome.org/gene/866895:HBHAL_RS00760 ^@ http://purl.uniprot.org/uniprot/I0JH98 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/866895:HBHAL_RS18470 ^@ http://purl.uniprot.org/uniprot/I0JSN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS00085 ^@ http://purl.uniprot.org/uniprot/I0JGY4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS18500 ^@ http://purl.uniprot.org/uniprot/I0JSN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13075 ^@ http://purl.uniprot.org/uniprot/I0JPF2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer. http://togogenome.org/gene/866895:HBHAL_RS12300 ^@ http://purl.uniprot.org/uniprot/I0JNZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS19460 ^@ http://purl.uniprot.org/uniprot/I0JT86 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/866895:HBHAL_RS19450 ^@ http://purl.uniprot.org/uniprot/I0JT84 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS14590 ^@ http://purl.uniprot.org/uniprot/I0JQB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/866895:HBHAL_RS00310 ^@ http://purl.uniprot.org/uniprot/I0JH23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease M5 family.|||Cytoplasm|||Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. http://togogenome.org/gene/866895:HBHAL_RS04300 ^@ http://purl.uniprot.org/uniprot/I0JJA8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12750 ^@ http://purl.uniprot.org/uniprot/I0JP87 ^@ Similarity ^@ Belongs to the UPF0473 family. http://togogenome.org/gene/866895:HBHAL_RS06450 ^@ http://purl.uniprot.org/uniprot/I0JKH5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/866895:HBHAL_RS10045 ^@ http://purl.uniprot.org/uniprot/I0JMM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum basal body|||Belongs to the FliR/MopE/SpaR family.|||Cell membrane|||Membrane|||Role in flagellar biosynthesis. http://togogenome.org/gene/866895:HBHAL_RS02550 ^@ http://purl.uniprot.org/uniprot/I0JI86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05480 ^@ http://purl.uniprot.org/uniprot/I0JJX8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS08530 ^@ http://purl.uniprot.org/uniprot/I0JLQ6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS18315 ^@ http://purl.uniprot.org/uniprot/I0JSJ9 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/866895:HBHAL_RS09715 ^@ http://purl.uniprot.org/uniprot/I0JMG1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS03905 ^@ http://purl.uniprot.org/uniprot/I0JJ25 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/866895:HBHAL_RS03115 ^@ http://purl.uniprot.org/uniprot/I0JIK5 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/866895:HBHAL_RS04455 ^@ http://purl.uniprot.org/uniprot/I0JJE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Bcr/CmlA family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05750 ^@ http://purl.uniprot.org/uniprot/I0JK30 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/866895:HBHAL_RS11020 ^@ http://purl.uniprot.org/uniprot/I0JN84 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS09815 ^@ http://purl.uniprot.org/uniprot/I0JMI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS12700 ^@ http://purl.uniprot.org/uniprot/I0JP77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS02555 ^@ http://purl.uniprot.org/uniprot/I0JI87 ^@ Function|||Similarity ^@ Belongs to the SELO family.|||Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). http://togogenome.org/gene/866895:HBHAL_RS14510 ^@ http://purl.uniprot.org/uniprot/I0JQ94 ^@ Similarity ^@ Belongs to the malate synthase family. http://togogenome.org/gene/866895:HBHAL_RS05535 ^@ http://purl.uniprot.org/uniprot/I0JJY8 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/866895:HBHAL_RS17095 ^@ http://purl.uniprot.org/uniprot/I0JRV1 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS19295 ^@ http://purl.uniprot.org/uniprot/I0JT55 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.|||Synthesizes alpha-1,4-glucan chains using ADP-glucose. http://togogenome.org/gene/866895:HBHAL_RS09925 ^@ http://purl.uniprot.org/uniprot/I0JMK3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/866895:HBHAL_RS06430 ^@ http://purl.uniprot.org/uniprot/I0JKG9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10505 ^@ http://purl.uniprot.org/uniprot/I0JMX5 ^@ Similarity ^@ Belongs to the CbxX/CfxQ family. http://togogenome.org/gene/866895:HBHAL_RS11270 ^@ http://purl.uniprot.org/uniprot/I0JND5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS18225 ^@ http://purl.uniprot.org/uniprot/I0JSH9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS09175 ^@ http://purl.uniprot.org/uniprot/I0JM47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FtsL family.|||Cell membrane|||Essential cell division protein.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS09165 ^@ http://purl.uniprot.org/uniprot/I0JM45 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/866895:HBHAL_RS02320 ^@ http://purl.uniprot.org/uniprot/I0JI36 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/866895:HBHAL_RS00665 ^@ http://purl.uniprot.org/uniprot/I0JH79 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/866895:HBHAL_RS05525 ^@ http://purl.uniprot.org/uniprot/I0JJY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.|||Cell membrane|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. http://togogenome.org/gene/866895:HBHAL_RS13255 ^@ http://purl.uniprot.org/uniprot/I0JPI2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS03685 ^@ http://purl.uniprot.org/uniprot/I0JIX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS16340 ^@ http://purl.uniprot.org/uniprot/I0JRC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS05460 ^@ http://purl.uniprot.org/uniprot/I0JJX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS18800 ^@ http://purl.uniprot.org/uniprot/I0JSV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS03970 ^@ http://purl.uniprot.org/uniprot/I0JJ39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS16555 ^@ http://purl.uniprot.org/uniprot/I0JRH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS07160 ^@ http://purl.uniprot.org/uniprot/I0JKX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS07795 ^@ http://purl.uniprot.org/uniprot/I0JL96 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/866895:HBHAL_RS16275 ^@ http://purl.uniprot.org/uniprot/I0JRB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS08060 ^@ http://purl.uniprot.org/uniprot/I0JLF7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/866895:HBHAL_RS19895 ^@ http://purl.uniprot.org/uniprot/I0JTH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1C family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS03200 ^@ http://purl.uniprot.org/uniprot/I0JIM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YejK family.|||nucleoid http://togogenome.org/gene/866895:HBHAL_RS16975 ^@ http://purl.uniprot.org/uniprot/I0JRS4 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/866895:HBHAL_RS11190 ^@ http://purl.uniprot.org/uniprot/I0JNB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS06165 ^@ http://purl.uniprot.org/uniprot/I0JKB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III. http://togogenome.org/gene/866895:HBHAL_RS12430 ^@ http://purl.uniprot.org/uniprot/I0JP20 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/866895:HBHAL_RS08690 ^@ http://purl.uniprot.org/uniprot/I0JLU1 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/866895:HBHAL_RS10940 ^@ http://purl.uniprot.org/uniprot/I0JN66 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/866895:HBHAL_RS08305 ^@ http://purl.uniprot.org/uniprot/I0JLK8 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/866895:HBHAL_RS17080 ^@ http://purl.uniprot.org/uniprot/I0JRU8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 42 family. http://togogenome.org/gene/866895:HBHAL_RS08990 ^@ http://purl.uniprot.org/uniprot/I0JM07 ^@ Similarity|||Subunit ^@ Belongs to the glutaminase family.|||Homotetramer. http://togogenome.org/gene/866895:HBHAL_RS07890 ^@ http://purl.uniprot.org/uniprot/I0JLC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS15160 ^@ http://purl.uniprot.org/uniprot/I0JQM5 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS09420 ^@ http://purl.uniprot.org/uniprot/I0JM98 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/866895:HBHAL_RS18965 ^@ http://purl.uniprot.org/uniprot/I0JSY8 ^@ Function|||Similarity ^@ Belongs to the Thz kinase family.|||Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). http://togogenome.org/gene/866895:HBHAL_RS10805 ^@ http://purl.uniprot.org/uniprot/I0JN37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/866895:HBHAL_RS06460 ^@ http://purl.uniprot.org/uniprot/I0JKH7 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/866895:HBHAL_RS15680 ^@ http://purl.uniprot.org/uniprot/I0JQY5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/866895:HBHAL_RS00820 ^@ http://purl.uniprot.org/uniprot/I0JHB0 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/866895:HBHAL_RS13500 ^@ http://purl.uniprot.org/uniprot/I0JPN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS04815 ^@ http://purl.uniprot.org/uniprot/I0JJL3 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/866895:HBHAL_RS13520 ^@ http://purl.uniprot.org/uniprot/I0JPN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS08820 ^@ http://purl.uniprot.org/uniprot/I0JLX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0053 family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12315 ^@ http://purl.uniprot.org/uniprot/I0JP02 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/866895:HBHAL_RS19135 ^@ http://purl.uniprot.org/uniprot/I0JT22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS18235 ^@ http://purl.uniprot.org/uniprot/I0JSI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS18340 ^@ http://purl.uniprot.org/uniprot/I0JSK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EamA transporter family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS10710 ^@ http://purl.uniprot.org/uniprot/I0JN18 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS15210 ^@ http://purl.uniprot.org/uniprot/I0JQN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS15315 ^@ http://purl.uniprot.org/uniprot/I0JQQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CbbQ/NirQ/NorQ/GpvN family.|||Cytoplasm|||Gas vesicle|||Vesicle http://togogenome.org/gene/866895:HBHAL_RS03490 ^@ http://purl.uniprot.org/uniprot/I0JIT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS00020 ^@ http://purl.uniprot.org/uniprot/I0JGX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/866895:HBHAL_RS11385 ^@ http://purl.uniprot.org/uniprot/I0JNF8 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/866895:HBHAL_RS07500 ^@ http://purl.uniprot.org/uniprot/I0JL38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11085 ^@ http://purl.uniprot.org/uniprot/I0JN97 ^@ Similarity ^@ Belongs to the UPF0302 family. http://togogenome.org/gene/866895:HBHAL_RS18160 ^@ http://purl.uniprot.org/uniprot/I0JSG6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS03595 ^@ http://purl.uniprot.org/uniprot/I0JIW0 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. DsdA subfamily. http://togogenome.org/gene/866895:HBHAL_RS15400 ^@ http://purl.uniprot.org/uniprot/I0JQS3 ^@ Similarity ^@ Belongs to the UPF0312 family. http://togogenome.org/gene/866895:HBHAL_RS02980 ^@ http://purl.uniprot.org/uniprot/I0JIH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fosfomycin resistance protein family. FosB subfamily.|||Cytoplasm|||Homodimer.|||Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. http://togogenome.org/gene/866895:HBHAL_RS05665 ^@ http://purl.uniprot.org/uniprot/I0JK13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS12280 ^@ http://purl.uniprot.org/uniprot/I0JNZ4 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/866895:HBHAL_RS12355 ^@ http://purl.uniprot.org/uniprot/I0JP11 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/866895:HBHAL_RS06655 ^@ http://purl.uniprot.org/uniprot/I0JKL9 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/866895:HBHAL_RS02005 ^@ http://purl.uniprot.org/uniprot/I0JHZ3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/866895:HBHAL_RS10195 ^@ http://purl.uniprot.org/uniprot/I0JMQ9 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/866895:HBHAL_RS12010 ^@ http://purl.uniprot.org/uniprot/I0JNU0 ^@ Cofactor|||Function|||Subcellular Location Annotation ^@ Binds 1 Ca(2+) ion per subunit.|||Cytoplasm|||May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box).|||May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. http://togogenome.org/gene/866895:HBHAL_RS12655 ^@ http://purl.uniprot.org/uniprot/I0JP67 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/866895:HBHAL_RS13950 ^@ http://purl.uniprot.org/uniprot/I0JPX8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS09315 ^@ http://purl.uniprot.org/uniprot/I0JM77 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS12225 ^@ http://purl.uniprot.org/uniprot/I0JNY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ComGC family.|||Cell membrane|||Homodimer.|||Required for transformation and DNA binding. http://togogenome.org/gene/866895:HBHAL_RS14760 ^@ http://purl.uniprot.org/uniprot/I0JQE3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/866895:HBHAL_RS15240 ^@ http://purl.uniprot.org/uniprot/D9ZZC7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS04435 ^@ http://purl.uniprot.org/uniprot/I0JJD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/866895:HBHAL_RS12815 ^@ http://purl.uniprot.org/uniprot/I0JP99 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/866895:HBHAL_RS08260 ^@ http://purl.uniprot.org/uniprot/I0JLJ7 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/866895:HBHAL_RS09975 ^@ http://purl.uniprot.org/uniprot/I0JML3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FliJ family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS13575 ^@ http://purl.uniprot.org/uniprot/I0JPQ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Cell membrane|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS00900 ^@ http://purl.uniprot.org/uniprot/I0JHC6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS19115 ^@ http://purl.uniprot.org/uniprot/I0JT17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LTA synthase family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS11230 ^@ http://purl.uniprot.org/uniprot/I0JNC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/866895:HBHAL_RS00160 ^@ http://purl.uniprot.org/uniprot/I0JGZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS09130 ^@ http://purl.uniprot.org/uniprot/I0JM38 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/866895:HBHAL_RS05885 ^@ http://purl.uniprot.org/uniprot/I0JK56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS17230 ^@ http://purl.uniprot.org/uniprot/I0JRX8 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. http://togogenome.org/gene/866895:HBHAL_RS02590 ^@ http://purl.uniprot.org/uniprot/I0JI96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11110 ^@ http://purl.uniprot.org/uniprot/I0JNA2 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS13590 ^@ http://purl.uniprot.org/uniprot/I0JPQ3 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/866895:HBHAL_RS19975 ^@ http://purl.uniprot.org/uniprot/I0JTJ4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GdpP/PdeA phosphodiesterase family.|||Cell membrane|||For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.|||Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP). http://togogenome.org/gene/866895:HBHAL_RS19860 ^@ http://purl.uniprot.org/uniprot/I0JTG9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/866895:HBHAL_RS05160 ^@ http://purl.uniprot.org/uniprot/I0JJT3 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. http://togogenome.org/gene/866895:HBHAL_RS09555 ^@ http://purl.uniprot.org/uniprot/I0JMC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06915 ^@ http://purl.uniprot.org/uniprot/I0JKS2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/866895:HBHAL_RS09210 ^@ http://purl.uniprot.org/uniprot/I0JM54 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS20015 ^@ http://purl.uniprot.org/uniprot/I0JTK0 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS19365 ^@ http://purl.uniprot.org/uniprot/I0JT68 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS17650 ^@ http://purl.uniprot.org/uniprot/I0JS66 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/866895:HBHAL_RS03040 ^@ http://purl.uniprot.org/uniprot/I0JIJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer. http://togogenome.org/gene/866895:HBHAL_RS16995 ^@ http://purl.uniprot.org/uniprot/I0JRT0 ^@ Similarity ^@ Belongs to the 6-phosphogluconate dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS04510 ^@ http://purl.uniprot.org/uniprot/I0JJF2 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/866895:HBHAL_RS09370 ^@ http://purl.uniprot.org/uniprot/I0JM88 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS14975 ^@ http://purl.uniprot.org/uniprot/I0JQI8 ^@ PTM ^@ Binds 1 heme c group covalently per subunit. http://togogenome.org/gene/866895:HBHAL_RS10900 ^@ http://purl.uniprot.org/uniprot/I0JN58 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. http://togogenome.org/gene/866895:HBHAL_RS19600 ^@ http://purl.uniprot.org/uniprot/I0JTB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS11345 ^@ http://purl.uniprot.org/uniprot/I0JNE9 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/866895:HBHAL_RS12880 ^@ http://purl.uniprot.org/uniprot/I0JPB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ArsB family.|||Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS07800 ^@ http://purl.uniprot.org/uniprot/I0JL97 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/866895:HBHAL_RS09575 ^@ http://purl.uniprot.org/uniprot/I0JMD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/866895:HBHAL_RS06545 ^@ http://purl.uniprot.org/uniprot/I0JKJ3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the MecA family.|||Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC.|||Homodimer.|||The N-terminal domain has binding sites for ComK and probably for unfolded/aggregated proteins; the C-terminal domain interacts with ClpC. http://togogenome.org/gene/866895:HBHAL_RS18175 ^@ http://purl.uniprot.org/uniprot/I0JSG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS17615 ^@ http://purl.uniprot.org/uniprot/I0JS59 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/866895:HBHAL_RS00385 ^@ http://purl.uniprot.org/uniprot/I0JH38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS09505 ^@ http://purl.uniprot.org/uniprot/I0JMB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/866895:HBHAL_RS14205 ^@ http://purl.uniprot.org/uniprot/I0JQ32 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/866895:HBHAL_RS19305 ^@ http://purl.uniprot.org/uniprot/I0JT57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. http://togogenome.org/gene/866895:HBHAL_RS09755 ^@ http://purl.uniprot.org/uniprot/I0JMH0 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/866895:HBHAL_RS13130 ^@ http://purl.uniprot.org/uniprot/I0JPG3 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/866895:HBHAL_RS12125 ^@ http://purl.uniprot.org/uniprot/I0JNW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/866895:HBHAL_RS09885 ^@ http://purl.uniprot.org/uniprot/I0JMJ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/866895:HBHAL_RS14080 ^@ http://purl.uniprot.org/uniprot/I0JQ05 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/866895:HBHAL_RS17220 ^@ http://purl.uniprot.org/uniprot/I0JRX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS20120 ^@ http://purl.uniprot.org/uniprot/I0JTM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/866895:HBHAL_RS10315 ^@ http://purl.uniprot.org/uniprot/I0JMT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane|||This protein catalyzes the committed step to the synthesis of the acidic phospholipids. http://togogenome.org/gene/866895:HBHAL_RS06715 ^@ http://purl.uniprot.org/uniprot/I0JKN4 ^@ Similarity ^@ Belongs to the 2H phosphoesterase superfamily. YjcG family. http://togogenome.org/gene/866895:HBHAL_RS12625 ^@ http://purl.uniprot.org/uniprot/I0JP61 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/866895:HBHAL_RS08675 ^@ http://purl.uniprot.org/uniprot/I0JLT8 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/866895:HBHAL_RS18830 ^@ http://purl.uniprot.org/uniprot/I0JSW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GerABKA family.|||Cell membrane|||Membrane http://togogenome.org/gene/866895:HBHAL_RS00890 ^@ http://purl.uniprot.org/uniprot/I0JHC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.|||Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).|||Membrane http://togogenome.org/gene/866895:HBHAL_RS12900 ^@ http://purl.uniprot.org/uniprot/I0JPB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).