http://togogenome.org/gene/9541:PPM1F ^@ http://purl.uniprot.org/uniprot/A0A7N9D1S3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:RPS13 ^@ http://purl.uniprot.org/uniprot/A0A2K5V043 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/9541:TMEM265 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDS6 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:CFHR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEE7|||http://purl.uniprot.org/uniprot/G8F5N7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DYNC1I1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPG5|||http://purl.uniprot.org/uniprot/A0A2K5TSB8|||http://purl.uniprot.org/uniprot/A0A2K5TSF5|||http://purl.uniprot.org/uniprot/A0A8J8XIW1 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/9541:GTF2H2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6X1|||http://purl.uniprot.org/uniprot/G7P7P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/9541:ANP32A ^@ http://purl.uniprot.org/uniprot/I7GHD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9541:TSPAN5 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCS4|||http://purl.uniprot.org/uniprot/A0A8J8Y6H9|||http://purl.uniprot.org/uniprot/G7P5Y5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:RIOK1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEB8|||http://purl.uniprot.org/uniprot/G7P4D1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/9541:CYRIA ^@ http://purl.uniprot.org/uniprot/A0A8J8XXW2|||http://purl.uniprot.org/uniprot/G7PLN0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9541:SSBP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9C9N4|||http://purl.uniprot.org/uniprot/A0A8J8XDD0|||http://purl.uniprot.org/uniprot/G7P1E9 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9541:MPV17 ^@ http://purl.uniprot.org/uniprot/A0A2K5W873|||http://purl.uniprot.org/uniprot/G7PLV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9541:ACAD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP11 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:FZD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U727|||http://purl.uniprot.org/uniprot/A0A8J8YDW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:FDFT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W905 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/9541:ACVRL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:GRIA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF45|||http://purl.uniprot.org/uniprot/A0A2K5UFB7|||http://purl.uniprot.org/uniprot/A0A8J8YCD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:EXOC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO84 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||growth cone|||perinuclear region http://togogenome.org/gene/9541:ZFPM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLG1|||http://purl.uniprot.org/uniprot/A0A2K5TLG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102145217 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9B8 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:AQP2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:MMAA ^@ http://purl.uniprot.org/uniprot/A0A2K5V0N3 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/9541:ISOC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIT7 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/9541:WEE1 ^@ http://purl.uniprot.org/uniprot/Q95JK5 ^@ Cofactor|||Similarity ^@ Belongs to the protein kinase superfamily.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/9541:SLITRK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMT4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:TMEM176A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9M3|||http://purl.uniprot.org/uniprot/G7P209 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9541:ZEB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W193|||http://purl.uniprot.org/uniprot/A0A2K5W1B1 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9541:PPP2R2B ^@ http://purl.uniprot.org/uniprot/A0A158SIQ6|||http://purl.uniprot.org/uniprot/A0A2K5U1Q0|||http://purl.uniprot.org/uniprot/A0A2K5U1Q5|||http://purl.uniprot.org/uniprot/A0A2K5U1U5|||http://purl.uniprot.org/uniprot/G7P8L1|||http://purl.uniprot.org/uniprot/Q4R8L3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase 2A regulatory subunit B family.|||Cytoplasm|||Membrane|||PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions) (By similarity).|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.|||cytoskeleton http://togogenome.org/gene/9541:HECTD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKG5 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/9541:LSM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3J7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/9541:GNG10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:LOC102133286 ^@ http://purl.uniprot.org/uniprot/A0A8J8XD17|||http://purl.uniprot.org/uniprot/G7Q3A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9541:KRT81 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWC1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:MRPL52 ^@ http://purl.uniprot.org/uniprot/A0A2K5X932 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL52 family.|||Mitochondrion http://togogenome.org/gene/9541:MMP12 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBR3|||http://purl.uniprot.org/uniprot/G7PNK7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9541:BEX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X340|||http://purl.uniprot.org/uniprot/G7Q3C0 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9541:PPARGC1A ^@ http://purl.uniprot.org/uniprot/A0A2K5X8F0|||http://purl.uniprot.org/uniprot/A0A2K5X8W4 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/9541:PARP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7T5 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:SRPX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS42 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SCUBE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBW0|||http://purl.uniprot.org/uniprot/A0A7N9DF80 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:SLC35E3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:BECN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V238|||http://purl.uniprot.org/uniprot/A0A2K5V263|||http://purl.uniprot.org/uniprot/A0A2K5V2A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/9541:MRPS18C ^@ http://purl.uniprot.org/uniprot/A0A2K5WDE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/9541:PFKFB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V967 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9541:ENTPD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC94|||http://purl.uniprot.org/uniprot/A0A2K5VCB1|||http://purl.uniprot.org/uniprot/G7NYI6 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:CNOT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W640|||http://purl.uniprot.org/uniprot/A0A8J8YH65|||http://purl.uniprot.org/uniprot/G7P6Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9541:B3GALNT1 ^@ http://purl.uniprot.org/uniprot/A0A7N9ICJ4|||http://purl.uniprot.org/uniprot/A0A8J8XWK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:C19H19orf12 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/9541:PRTFDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY00|||http://purl.uniprot.org/uniprot/A0A2K5WYI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/9541:PDK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:HYLS1 ^@ http://purl.uniprot.org/uniprot/G7PPM8|||http://purl.uniprot.org/uniprot/Q4R2Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HYLS1 family.|||Cytoplasm|||Plays a role in ciliogenesis.|||centriole|||cilium http://togogenome.org/gene/9541:POLR1B ^@ http://purl.uniprot.org/uniprot/A0A2K5V5H3 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. http://togogenome.org/gene/9541:BMPR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0S9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/9541:SLC35A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:EMSY ^@ http://purl.uniprot.org/uniprot/A0A2K5VWJ6|||http://purl.uniprot.org/uniprot/A0A2K5VWT6|||http://purl.uniprot.org/uniprot/A0A8J8YMX9|||http://purl.uniprot.org/uniprot/G7PNA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RPS12 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCC6|||http://purl.uniprot.org/uniprot/G7P346 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/9541:MFSD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAW8|||http://purl.uniprot.org/uniprot/A0A2K5VB08|||http://purl.uniprot.org/uniprot/G8F4L8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MOB3B ^@ http://purl.uniprot.org/uniprot/A0A8J8YK25|||http://purl.uniprot.org/uniprot/G7PS66 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:SBDS ^@ http://purl.uniprot.org/uniprot/A0A2K5V3B1 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/9541:LOC102126915 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK87 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:BTG1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIC1 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:RBBP4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D3U8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:API5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH3 ^@ Similarity ^@ Belongs to the API5 family. http://togogenome.org/gene/9541:CARMIL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9541:PFKFB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VX43|||http://purl.uniprot.org/uniprot/G7NUP7 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9541:TP53I11 ^@ http://purl.uniprot.org/uniprot/A0A7N9CI61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TPMT ^@ http://purl.uniprot.org/uniprot/A0A2K5V568 ^@ Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Monomer. http://togogenome.org/gene/9541:RPLP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6Z8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9541:MDK ^@ http://purl.uniprot.org/uniprot/A0A2K5UAU4 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9541:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A2K5V537|||http://purl.uniprot.org/uniprot/A0A2K5V567 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:VEGFD ^@ http://purl.uniprot.org/uniprot/A0A8J8Y018|||http://purl.uniprot.org/uniprot/G7Q297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9541:SPOPL ^@ http://purl.uniprot.org/uniprot/A0A2K5TT09|||http://purl.uniprot.org/uniprot/A0A8J8YI43 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/9541:NME7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5S7|||http://purl.uniprot.org/uniprot/A0A7N9CSI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/9541:VWC2L ^@ http://purl.uniprot.org/uniprot/A0A2K5UC09|||http://purl.uniprot.org/uniprot/A0A8J8YL83 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/9541:SAR1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WYE8 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9541:LOC102145245 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:ABCB8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL14|||http://purl.uniprot.org/uniprot/A0A8J8Y2Y8|||http://purl.uniprot.org/uniprot/G7P213 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NFE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKY3|||http://purl.uniprot.org/uniprot/G8F5B9 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9541:GALNT14 ^@ http://purl.uniprot.org/uniprot/A0A7N9C9A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:LOC102133222 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5I7 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9541:CXCR6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6U6|||http://purl.uniprot.org/uniprot/A0A7N9DCG8 ^@ Function|||Similarity ^@ Belongs to the G-protein coupled receptor 1 family.|||Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. http://togogenome.org/gene/9541:LOC102123623 ^@ http://purl.uniprot.org/uniprot/A0A2K5URR0|||http://purl.uniprot.org/uniprot/A0A7N9CR01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/9541:LOC102127733 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DNAI7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZS8 ^@ Similarity ^@ Belongs to the DNAI7 family. http://togogenome.org/gene/9541:NXT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHH8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9541:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKM8|||http://purl.uniprot.org/uniprot/G7PSC3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:POU5F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9541:LOC102127391 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCG6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:PRR15L ^@ http://purl.uniprot.org/uniprot/A0A2K5UP02 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9541:SHCBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEF9 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/9541:ANXA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7S4|||http://purl.uniprot.org/uniprot/A0A8J8XSE0|||http://purl.uniprot.org/uniprot/G7P536 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9541:IL2RB ^@ http://purl.uniprot.org/uniprot/Q38J85 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Cell surface|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation (By similarity).|||Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation. http://togogenome.org/gene/9541:LALBA ^@ http://purl.uniprot.org/uniprot/A0A8J8YQW7|||http://purl.uniprot.org/uniprot/G7PHQ9 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/9541:RNF7 ^@ http://purl.uniprot.org/uniprot/A0A7N9CCY2 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/9541:MEP1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TPQ3 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PPP4R3A ^@ http://purl.uniprot.org/uniprot/A0A2K5UC63 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9541:PAH ^@ http://purl.uniprot.org/uniprot/A0A2K5W2M4 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9541:PPIL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V405 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:HIGD1A ^@ http://purl.uniprot.org/uniprot/A0A8J8YGQ2|||http://purl.uniprot.org/uniprot/G7NY64 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9541:PGPEP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CFL0|||http://purl.uniprot.org/uniprot/A0A8J8Y4Q6|||http://purl.uniprot.org/uniprot/G7PWZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/9541:CCSER2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYN7|||http://purl.uniprot.org/uniprot/A0A2K5VYP3|||http://purl.uniprot.org/uniprot/A0A2K5VYQ5|||http://purl.uniprot.org/uniprot/A0A8J8XAJ5 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9541:MLC1 ^@ http://purl.uniprot.org/uniprot/Q60HE7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Endoplasmic reticulum|||Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM.|||Membrane|||Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.|||perinuclear region http://togogenome.org/gene/9541:MAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBY9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:DUSP10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XX38|||http://purl.uniprot.org/uniprot/G7NTY0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:AZIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2C9 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9541:MAPK10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUM6|||http://purl.uniprot.org/uniprot/A0A2K5TVL4|||http://purl.uniprot.org/uniprot/G7P5U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/9541:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAR9|||http://purl.uniprot.org/uniprot/A0A2K5UAV8|||http://purl.uniprot.org/uniprot/A0A2K5UB16|||http://purl.uniprot.org/uniprot/A0A2K5UB38 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9541:TNPO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSA9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:ANKRD34B ^@ http://purl.uniprot.org/uniprot/A0A8J8XFW9|||http://purl.uniprot.org/uniprot/G7P7V3 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/9541:CACFD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel flower family.|||Membrane http://togogenome.org/gene/9541:CHMP2A ^@ http://purl.uniprot.org/uniprot/A0A8J8XJE1|||http://purl.uniprot.org/uniprot/G7PZC8 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:ZNF174 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK10 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CBLL1 ^@ http://purl.uniprot.org/uniprot/Q4R7I8 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Hakai family.|||Cytoplasm|||E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.|||Homodimer. Interacts with tyrosine-phosphorylated SRC substrates. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of METTL3 and METTL14. The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (By similarity). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (By similarity).|||Nucleus speckle|||Phosphorylated on tyrosine residues.|||The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.|||nucleoplasm http://togogenome.org/gene/9541:UNC45A ^@ http://purl.uniprot.org/uniprot/A0A2K5W2E7 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/9541:ZSCAN21 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYU1|||http://purl.uniprot.org/uniprot/G7P0C2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC27A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2A2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:STAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CCND2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNL4|||http://purl.uniprot.org/uniprot/G7PJL4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:ASZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3L9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. http://togogenome.org/gene/9541:FAM199X ^@ http://purl.uniprot.org/uniprot/A0A2K5X7I9 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/9541:KCTD20 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6B5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SLC2A5 ^@ http://purl.uniprot.org/uniprot/A0A7N9IEN2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane|||Membrane|||sarcolemma http://togogenome.org/gene/9541:SLC24A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9541:CDK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3E5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:CCR8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XUI3|||http://purl.uniprot.org/uniprot/G7NYJ2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A2K5TVV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/9541:LZIC ^@ http://purl.uniprot.org/uniprot/A0A2K5WIK2|||http://purl.uniprot.org/uniprot/G7NU54 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/9541:PJVK ^@ http://purl.uniprot.org/uniprot/A0A8J8YQB6|||http://purl.uniprot.org/uniprot/G7PKX8 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/9541:DLX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFH5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:S100A11 ^@ http://purl.uniprot.org/uniprot/A0A7N9CR25 ^@ Function|||Similarity|||Subunit ^@ Belongs to the S-100 family.|||Facilitates the differentiation and the cornification of keratinocytes.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9541:URM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBC9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm http://togogenome.org/gene/9541:MMP20 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT27 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9541:CORT ^@ http://purl.uniprot.org/uniprot/A0A2K5V9I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9541:RPL36 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFN5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/9541:DKK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9541:CPT2 ^@ http://purl.uniprot.org/uniprot/Q60HG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/G7P0H6 ^@ Subcellular Location Annotation ^@ trans-Golgi network membrane http://togogenome.org/gene/9541:LOC101926433 ^@ http://purl.uniprot.org/uniprot/A0A2K5U698|||http://purl.uniprot.org/uniprot/A0A2K5U6B3|||http://purl.uniprot.org/uniprot/A0A2K5U6L3|||http://purl.uniprot.org/uniprot/P53601 ^@ Caution|||Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Amyloid-beta peptides are degraded by IDE.|||Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron (By similarity).|||Belongs to the APP family.|||Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and NUMB and DAB1 (By similarity). Binding to DAB1 inhibits its serine phosphorylation (By similarity). Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Also interacts with GPCR-like protein BPP, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1. Amyloid-beta protein 42 binds CHRNA7 in hippocampal neurons (By similarity). Amyloid-beta associates with HADH2 (By similarity). Interacts with CPEB1, ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; dimerization is enhanced in the presence of Cu(2+) ions. Can form homodimers; this is promoted by heparin binding (By similarity). Amyloid-beta protein 40 interacts with S100A9 (By similarity). CTF-alpha product of APP interacts with GSAP (By similarity). Isoform APP695 interacts with SORL1 (via N-terminal ectodomain); this interaction retains APP in the trans-Golgi network and reduces processing into soluble APP-alpha and amyloid-beta peptides (By similarity). Isoform APP770 interacts with SORL1 (By similarity). The C99 fragment also interacts with SORL1 (By similarity). Interacts with PLD3 (By similarity). Interacts with VDAC1 (By similarity). Interacts with NSG1; could regulate APP processing (By similarity). Amyloid-beta protein 42 interacts with FPR2 (By similarity). Interacts (via transmembrane region) with PSEN1; the interaction is direct (By similarity). Interacts with LRRK2 (By similarity). Interacts (via cytoplasmic domain) with KIF5B (By similarity). Interacts (via C-terminus) with APBB2/FE65L1 (via C-terminus) (By similarity). Interacts (via intracellular domain) with APBB3 (By similarity).|||Cell membrane|||Cell surface|||Chelation of metal ions, notably copper, iron and zinc, can induce histidine-bridging between amyloid-beta molecules resulting in amyloid-beta-metal aggregates. Extracellular zinc-binding increases binding of heparin to APP and inhibits collagen-binding.|||Cytoplasm|||Cytoplasmic vesicle|||Early endosome|||Endoplasmic reticulum|||Endosome|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.|||Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP (By similarity). Inhibits G(o)-alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction (By similarity). In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation (By similarity). Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).|||Golgi apparatus|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N- and O-glycosylated.|||N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).|||Nucleus|||Perikaryon|||Phosphorylation in the C-terminal on tyrosine, threonine and serine residues is neuron-specific. Phosphorylation can affect APP processing, neuronal differentiation and interaction with other proteins. Phosphorylated on Thr-743 in neuronal cells by Cdc5 kinase and Mapk10, in dividing cells by Cdc2 kinase in a cell-cycle dependent manner with maximal levels at the G2/M phase and, in vitro, by GSK-3-beta. The Thr-743 phosphorylated form causes a conformational change which reduces binding of Fe65 family members. In dopaminergic (DA) neurons, phosphorylation on Thr-743 by LRKK2 promotes the production and the nuclear translocation of the APP intracellular domain (AICD) which induces DA neuron apoptosis. Phosphorylation on Tyr-757 is required for SHC binding. Phosphorylated in the extracellular domain by casein kinases on both soluble and membrane-bound APP. This phosphorylation is inhibited by heparin.|||Proteolytically cleaved by caspases during neuronal apoptosis. Cleavage at Asp-739 by either caspase-3, -8 or -9 results in the production of the neurotoxic C31 peptide and the increased production of amyloid-beta peptides.|||Proteolytically processed under normal cellular conditions. Cleavage either by alpha-secretase, beta-secretase or theta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, and the retention of corresponding membrane-anchored C-terminal fragments, C80, C83 and C99. Subsequent processing of C80 and C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is non-amyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid-beta proteins, amyloid-beta protein 40 and amyloid-beta protein 42, major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59). PSEN1 cleavage is more efficient with C83 than with C99 as substrate (in vitro). Amyloid-beta protein 40 and Amyloid-beta protein 42 are cleaved by ACE. Many other minor amyloid-beta peptides, amyloid-beta 1-X peptides, are found in cerebral spinal fluid (CSF) including the amyloid-beta X-15 peptides, produced from the cleavage by alpha-secretase.|||Secreted|||Sulfated on tyrosine residues.|||The C-terminal region can bind zinc ions; this favors dimerization and formation of higher oligomers.|||The GFLD subdomain binds Cu(2+) ions; this promotes homodimerization.|||The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The PID domain-containing proteins which bind APP require the YENPTY motif for full interaction. These interactions are independent of phosphorylation on the terminal tyrosine residue. The YENPXY site is also involved in clathrin-mediated endocytosis.|||The OX-2 motif shows some similarity to a region in the N-terminus of CD200/MOX2.|||The basolateral sorting signal (BaSS) is required for sorting of membrane proteins to the basolateral surface of epithelial cells.|||The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.|||The transmembrane helix undergoes a conformation change and unravels partially when bound to PSEN1, facilitating cleavage by PSEN1.|||Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP).|||Vesicle|||clathrin-coated pit|||growth cone http://togogenome.org/gene/9541:RNF170 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWH0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TBCC ^@ http://purl.uniprot.org/uniprot/A0A2K5W8E9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCC family.|||Cytoplasm|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. http://togogenome.org/gene/9541:IGF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VND9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.|||Secreted http://togogenome.org/gene/9541:PICALM ^@ http://purl.uniprot.org/uniprot/A0A2K5WE69|||http://purl.uniprot.org/uniprot/A0A2K5WEB3|||http://purl.uniprot.org/uniprot/A0A2K5WEK1|||http://purl.uniprot.org/uniprot/A0A2K5WES9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PICALM/SNAP91 family.|||Membrane http://togogenome.org/gene/9541:SDE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:POLR1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WRU9 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9541:CD164 ^@ http://purl.uniprot.org/uniprot/A0A2K5U496|||http://purl.uniprot.org/uniprot/A0A7N9C9R9|||http://purl.uniprot.org/uniprot/A0A7N9ID13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/9541:LOC102128132 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPI1|||http://purl.uniprot.org/uniprot/G7P1L2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:LIPG ^@ http://purl.uniprot.org/uniprot/A0A2K5TPF3|||http://purl.uniprot.org/uniprot/G8F3E1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:LOXL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWM8 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9541:UCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3M5 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9541:SPATA20 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMY6 ^@ Function|||Subcellular Location Annotation ^@ May play a role in fertility regulation.|||Secreted http://togogenome.org/gene/9541:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/9541:NFU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7D5 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/9541:SPECC1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/9541:NKAIN3 ^@ http://purl.uniprot.org/uniprot/I7GNL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DKK3 ^@ http://purl.uniprot.org/uniprot/Q4R4I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9541:ELK4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ43|||http://purl.uniprot.org/uniprot/G7NVC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:KCTD6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEU1|||http://purl.uniprot.org/uniprot/G7NZB5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:MTMR12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJS6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9541:INSIG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V608 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/9541:TUB ^@ http://purl.uniprot.org/uniprot/A0A2K5UYI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/9541:FOXN2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI45|||http://purl.uniprot.org/uniprot/G7PM65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:IL12RB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/9541:HDAC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/9541:CALHM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/A0A2K5V6L5 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/9541:SNRNP200 ^@ http://purl.uniprot.org/uniprot/A0A2K5X457 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/9541:LOC102122521 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2C7|||http://purl.uniprot.org/uniprot/G7PWD9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9541:FHL5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGZ4|||http://purl.uniprot.org/uniprot/G7P427|||http://purl.uniprot.org/uniprot/Q4R7A4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.|||May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity).|||May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/9541:GDPD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDT2|||http://purl.uniprot.org/uniprot/A0A8J8YKA5|||http://purl.uniprot.org/uniprot/G7PN97 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:CCL20 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:TEX261 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/9541:TPM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9541:PARVA ^@ http://purl.uniprot.org/uniprot/A0A2K5TN80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CASP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1I1 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:PFN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVF5|||http://purl.uniprot.org/uniprot/G7PLR1 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9541:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM88|||http://purl.uniprot.org/uniprot/A0A7N9D5S5|||http://purl.uniprot.org/uniprot/G7NTL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Golgi apparatus membrane|||Midbody|||Mitochondrion outer membrane|||autophagosome membrane http://togogenome.org/gene/9541:CHMP1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WKS4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:CLDN20 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJE1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:ARF6 ^@ http://purl.uniprot.org/uniprot/G7PA78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/9541:GINS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9541:TIMM9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX31 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9541:LOC102133993 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTV2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:SLC16A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9541:DUSP12 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMK3|||http://purl.uniprot.org/uniprot/G7NXC0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:CD200R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLW2 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/9541:SERPINI1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5L9|||http://purl.uniprot.org/uniprot/G7NZG9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XG87|||http://purl.uniprot.org/uniprot/G7P1A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9541:MSN ^@ http://purl.uniprot.org/uniprot/A0A2K5WCE4 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9541:MT3 ^@ http://purl.uniprot.org/uniprot/G7Q160|||http://purl.uniprot.org/uniprot/Q2PFZ0 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity).|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9541:HOXC10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9541:GPR68 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC27 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:GATA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1K4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:S100G ^@ http://purl.uniprot.org/uniprot/A0A2K5V3E4 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:STX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:LOC102124284 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:PPAT ^@ http://purl.uniprot.org/uniprot/A0A8J8YHF4|||http://purl.uniprot.org/uniprot/G7P5S2 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9541:ACTL8 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4N5|||http://purl.uniprot.org/uniprot/G7NUR7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:TIPRL ^@ http://purl.uniprot.org/uniprot/A0A2K5VUG0 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/9541:PTP4A1 ^@ http://purl.uniprot.org/uniprot/Q9TSM6 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the protein-tyrosine phosphatase family.|||Cell membrane|||Cytoplasm|||Early endosome|||Endoplasmic reticulum|||Farnesylated. Farnesylation is required for membrane targeting (By similarity).|||Homotrimer. Interacts with ATF5 and tubulin (By similarity).|||In the retina, expressed by red/green- but not blue-sensitive cone photoreceptor cells, and by rod bipolar cells (at protein level).|||Inhibited by sodium orthovanadate and pentamidine.|||Nucleus|||Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).|||spindle http://togogenome.org/gene/9541:VPS26B ^@ http://purl.uniprot.org/uniprot/A0A8J8XCF9|||http://purl.uniprot.org/uniprot/G7PPW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9541:LOC102125581 ^@ http://purl.uniprot.org/uniprot/G7P1K7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:BSX ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ41 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PPIB ^@ http://purl.uniprot.org/uniprot/A0A2K5UAH0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:ATP5PF ^@ http://purl.uniprot.org/uniprot/Q8SPH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CEP19 ^@ http://purl.uniprot.org/uniprot/A0A7N9IDV7|||http://purl.uniprot.org/uniprot/A0A8J8XSK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/9541:MRPL35 ^@ http://purl.uniprot.org/uniprot/A0A7N9D929|||http://purl.uniprot.org/uniprot/G8F3R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/9541:GCNT3 ^@ http://purl.uniprot.org/uniprot/G7PBK8 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SLC25A44 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAQ3|||http://purl.uniprot.org/uniprot/G7NV80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:SERPINA11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTE5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:SPTAN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKZ4|||http://purl.uniprot.org/uniprot/A0A2K5VL04|||http://purl.uniprot.org/uniprot/A0A2K5VL65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9541:CSRNP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9541:ACADSB ^@ http://purl.uniprot.org/uniprot/Q4R4S2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:CDK11B ^@ http://purl.uniprot.org/uniprot/A0A2K5VNP7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9541:EVA1A ^@ http://purl.uniprot.org/uniprot/A0A2K5UI30 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/9541:YIPF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:BRINP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQM2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9541:BABAM1 ^@ http://purl.uniprot.org/uniprot/I7G8X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BABAM1 family.|||Nucleus http://togogenome.org/gene/9541:FAM133A ^@ http://purl.uniprot.org/uniprot/A0A2K5UK81 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/9541:HEBP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGT6|||http://purl.uniprot.org/uniprot/G7PJW7 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/9541:BOLA2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WT49 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9541:HSDL2 ^@ http://purl.uniprot.org/uniprot/G7PRN7 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9541:ARSH ^@ http://purl.uniprot.org/uniprot/A0A8J8XL05|||http://purl.uniprot.org/uniprot/G7Q249 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9541:ABCA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PPIH ^@ http://purl.uniprot.org/uniprot/A0A2K5WFR7|||http://purl.uniprot.org/uniprot/A0A2K5WFS1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:LOC102122620 ^@ http://purl.uniprot.org/uniprot/G8F5H6 ^@ Function|||Subunit ^@ In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:PKN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ73|||http://purl.uniprot.org/uniprot/A0A8J8YH34|||http://purl.uniprot.org/uniprot/G7NTM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/9541:AKR1D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT14|||http://purl.uniprot.org/uniprot/G8F421 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9541:LOC102125224 ^@ http://purl.uniprot.org/uniprot/G7Q2M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:GRPR ^@ http://purl.uniprot.org/uniprot/A0A2K5U3F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/9541:TBX19 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:SLC25A40 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGN4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TMEM98 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y645|||http://purl.uniprot.org/uniprot/G7PU17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9541:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY08|||http://purl.uniprot.org/uniprot/A0A2K5WY84 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9541:LMX1A ^@ http://purl.uniprot.org/uniprot/A0A8J8YD50|||http://purl.uniprot.org/uniprot/G7NU26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CHD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6Y8 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/9541:MRFAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UET2 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9541:DCN ^@ http://purl.uniprot.org/uniprot/A0A8J8Y354|||http://purl.uniprot.org/uniprot/Q4R5D2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/9541:KRT38 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNE6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:NFIX ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ42|||http://purl.uniprot.org/uniprot/I7GMK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9541:PIGO ^@ http://purl.uniprot.org/uniprot/A0A2K5W6E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:NR4A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEP2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/9541:NAA11 ^@ http://purl.uniprot.org/uniprot/G7P533 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9541:SRD5A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDR0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/9541:INHBE ^@ http://purl.uniprot.org/uniprot/A0A8J8YNK9|||http://purl.uniprot.org/uniprot/G7PIV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9541:NAP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUU8|||http://purl.uniprot.org/uniprot/A0A2K5TUV1 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9541:MFF ^@ http://purl.uniprot.org/uniprot/A0A2K5X6A5|||http://purl.uniprot.org/uniprot/A0A2K5X6D5|||http://purl.uniprot.org/uniprot/A0A2K5X6D8|||http://purl.uniprot.org/uniprot/A0A2K5X6U7|||http://purl.uniprot.org/uniprot/A0A7N9I9D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.|||synaptic vesicle http://togogenome.org/gene/9541:PTPRK ^@ http://purl.uniprot.org/uniprot/A0A2K5WV32|||http://purl.uniprot.org/uniprot/A0A7N9CLR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9541:BAG6 ^@ http://purl.uniprot.org/uniprot/G7P4P8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).|||cytosol|||extracellular exosome http://togogenome.org/gene/9541:LOC102121923 ^@ http://purl.uniprot.org/uniprot/A0A7N9D2F1 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:MYF6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFV7|||http://purl.uniprot.org/uniprot/G7PIK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102145093 ^@ http://purl.uniprot.org/uniprot/Q4R9D1 ^@ Function|||PTM|||Similarity|||Subunit ^@ Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.|||Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.|||Belongs to the ubiquitin-conjugating enzyme family.|||Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2. http://togogenome.org/gene/9541:ERGIC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJC9|||http://purl.uniprot.org/uniprot/A0A2K5WJF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9541:TNFSF15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA22 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:PNPLA4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D1X4|||http://purl.uniprot.org/uniprot/A0A8J8XB00|||http://purl.uniprot.org/uniprot/G7Q263 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MRPL24 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEQ1|||http://purl.uniprot.org/uniprot/G8F6F0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9541:EIF3G ^@ http://purl.uniprot.org/uniprot/A0A2K5WAN0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.|||perinuclear region http://togogenome.org/gene/9541:SF3A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ38 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102122063 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102115347 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRZ2 ^@ Cofactor|||Similarity ^@ Belongs to the HAD-like hydrolase superfamily.|||Divalent metal ions. Mg(2+) is the most effective. http://togogenome.org/gene/9541:TSACC ^@ http://purl.uniprot.org/uniprot/Q4R7E8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TSACC family.|||Co-chaperone that facilitates HSP-mediated activation of TSSK6.|||Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90 (By similarity). http://togogenome.org/gene/9541:MFN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRH2|||http://purl.uniprot.org/uniprot/A0A8J8YMS9 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:AHCYL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMN0 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/9541:LOC101864872 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNF2 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:TGIF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U881 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NAB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7H0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9541:SERINC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9541:CTBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/9541:KPNA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYJ5|||http://purl.uniprot.org/uniprot/G7NXS0 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:IL1RAPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||axon|||dendrite http://togogenome.org/gene/9541:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSA6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:MTX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAE1|||http://purl.uniprot.org/uniprot/A0A8J8Y6Z0|||http://purl.uniprot.org/uniprot/G7P7U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:TRMT2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WNL5 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LAMP5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGG8|||http://purl.uniprot.org/uniprot/G7PGY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:TEKT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9541:HOXB8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ82 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9541:ABCG5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9541:YPEL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W800 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9541:PDE4B ^@ http://purl.uniprot.org/uniprot/A0A2K5U5Z5|||http://purl.uniprot.org/uniprot/A0A8J8YHZ4|||http://purl.uniprot.org/uniprot/G7NW27 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:ACP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKD7|||http://purl.uniprot.org/uniprot/A0A7N9IEE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/9541:KDSR ^@ http://purl.uniprot.org/uniprot/A0A7N9IDX9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:MOS ^@ http://purl.uniprot.org/uniprot/A0A2K5UF73 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:C4H6orf120 ^@ http://purl.uniprot.org/uniprot/Q9BGQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.|||Secreted http://togogenome.org/gene/9541:CETN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDL5 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/9541:SLC28A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9541:CHCHD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XW51|||http://purl.uniprot.org/uniprot/G7PIL3 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/9541:HMGA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEY0|||http://purl.uniprot.org/uniprot/A0A2K5VF57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/9541:CKAP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOG/XMAP215 family.|||kinetochore http://togogenome.org/gene/9541:CCNG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7D5 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:SLITRK2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCU9|||http://purl.uniprot.org/uniprot/G7Q1V4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:GLYR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/9541:SPAM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CRYGN ^@ http://purl.uniprot.org/uniprot/A0A2K5VIL8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:ASB10 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULT4|||http://purl.uniprot.org/uniprot/A0A2K5ULT9 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:PPP4C ^@ http://purl.uniprot.org/uniprot/A0A2K5U642 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9541:CHST9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFQ8|||http://purl.uniprot.org/uniprot/G7PWJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:NRP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5B8 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYX9|||http://purl.uniprot.org/uniprot/A0A2K5UYY2|||http://purl.uniprot.org/uniprot/A0A2K5UZ16|||http://purl.uniprot.org/uniprot/A0A2K5UZ21|||http://purl.uniprot.org/uniprot/A0A2K5UZ55|||http://purl.uniprot.org/uniprot/Q2PFU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9541:HSPB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UR85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9541:H1-4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8N7|||http://purl.uniprot.org/uniprot/G7P2M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:SUFU ^@ http://purl.uniprot.org/uniprot/G7PDV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).|||Nucleus http://togogenome.org/gene/9541:PHOSPHO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V191 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/9541:ANAPC10 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8L7|||http://purl.uniprot.org/uniprot/A0A7N9IH85|||http://purl.uniprot.org/uniprot/I7GEV9 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9541:CNR1 ^@ http://purl.uniprot.org/uniprot/G7P3K6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.|||Interacts (via C-terminus) with CNRIP1.|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/9541:TMEM14A ^@ http://purl.uniprot.org/uniprot/A0A2K5UQD5 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9541:CA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U255 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:LOC102138082 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCMBP family.|||Nucleus http://togogenome.org/gene/9541:TSPAN12 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYI1|||http://purl.uniprot.org/uniprot/G7P0I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:GALNT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:BRPF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVC2|||http://purl.uniprot.org/uniprot/A0A8J8XYP3|||http://purl.uniprot.org/uniprot/G7NYU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FIS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPZ8|||http://purl.uniprot.org/uniprot/G7P145 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/9541:USE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X308 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102144965 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULV2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:CASP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYW8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A8J8YGP1|||http://purl.uniprot.org/uniprot/G7PLY1 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/9541:KCNJ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/9541:DCTN2 ^@ http://purl.uniprot.org/uniprot/I7GHC5 ^@ Similarity ^@ Belongs to the dynactin subunit 2 family. http://togogenome.org/gene/9541:PLD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPG7 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9541:TMEM245 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKF6|||http://purl.uniprot.org/uniprot/A0A7N9IC78|||http://purl.uniprot.org/uniprot/A0A7N9ICT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/9541:NFYA ^@ http://purl.uniprot.org/uniprot/A0A2K5WQS6|||http://purl.uniprot.org/uniprot/A0A7N9DA59|||http://purl.uniprot.org/uniprot/A0A8J8XVK6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/9541:PSMG2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8Q2|||http://purl.uniprot.org/uniprot/G7PWB8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/9541:TAS2R41 ^@ http://purl.uniprot.org/uniprot/G7P1I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:ATF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPW8|||http://purl.uniprot.org/uniprot/G7PIA6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:UTP11 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJG7|||http://purl.uniprot.org/uniprot/G7NUB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/9541:DUSP29 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMM7 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9541:SDR9C7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WES2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:LACTB2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH33|||http://purl.uniprot.org/uniprot/G7PC06 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/9541:ELOVL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9541:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDJ4 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9541:CAPN11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3S1 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/9541:APOBEC3G ^@ http://purl.uniprot.org/uniprot/Q05JX4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm|||DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.|||Homodimer.|||Nucleus|||P-body|||The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity. http://togogenome.org/gene/9541:RAD23A ^@ http://purl.uniprot.org/uniprot/A0A2K5W9S8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/9541:CAPZA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/9541:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8E2|||http://purl.uniprot.org/uniprot/A0A2K5W8K0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:ELOVL3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4P6|||http://purl.uniprot.org/uniprot/G7PDU3 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL3 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/9541:CRIPT ^@ http://purl.uniprot.org/uniprot/A0A2K5U226 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/9541:POLR2I ^@ http://purl.uniprot.org/uniprot/A0A8J8XYY8|||http://purl.uniprot.org/uniprot/G7PXC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9541:NDUFC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:GTF2F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. http://togogenome.org/gene/9541:TAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/9541:MAGT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:ORC2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQH4|||http://purl.uniprot.org/uniprot/Q4R797 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/9541:SETD6 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0A5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.|||Nucleus|||Protein-lysine N-methyltransferase. http://togogenome.org/gene/9541:GAST ^@ http://purl.uniprot.org/uniprot/A0A2K5V138 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.|||Secreted http://togogenome.org/gene/9541:B3GAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:ATP5F1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TVD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/9541:LIM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6W6|||http://purl.uniprot.org/uniprot/G7PYH7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. http://togogenome.org/gene/9541:PPP1R2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWF8|||http://purl.uniprot.org/uniprot/G7NYS0 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 2 family. http://togogenome.org/gene/9541:TEF ^@ http://purl.uniprot.org/uniprot/A0A2K5V8M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9541:EDNRA ^@ http://purl.uniprot.org/uniprot/A0A2K5TPJ0|||http://purl.uniprot.org/uniprot/A0A8J8YQK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/9541:PPP2R3C ^@ http://purl.uniprot.org/uniprot/A0A8J8YFJ9|||http://purl.uniprot.org/uniprot/G7PA30 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:BPNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD40|||http://purl.uniprot.org/uniprot/A0A2K5WD73 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/9541:MYMK ^@ http://purl.uniprot.org/uniprot/A0A2K5TN97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:POLR2E ^@ http://purl.uniprot.org/uniprot/A0A8J8Y181|||http://purl.uniprot.org/uniprot/G7PYA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.|||Nucleus http://togogenome.org/gene/9541:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A2K5TPT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.|||Nucleus http://togogenome.org/gene/9541:CRHR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/9541:GDE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ26 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:GCSH ^@ http://purl.uniprot.org/uniprot/A0A8J8YM65|||http://purl.uniprot.org/uniprot/G7PZT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9541:LOC102122055 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Endoplasmic reticulum|||In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.|||Membrane|||Mitochondrion inner membrane|||Monomer. Also occurs as a complex with tryptase in mast cells.|||Nucleus membrane|||cytosol|||extracellular matrix http://togogenome.org/gene/9541:NSG2 ^@ http://purl.uniprot.org/uniprot/Q4R4W7 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/9541:PC ^@ http://purl.uniprot.org/uniprot/A0A2K5VMP7 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/9541:PTK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SMIM19 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIJ5|||http://purl.uniprot.org/uniprot/G7PBS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/9541:ERLIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URK3|||http://purl.uniprot.org/uniprot/A0A7N9CRK4|||http://purl.uniprot.org/uniprot/A0A8J8YHC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9541:C3H7orf25 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKP3|||http://purl.uniprot.org/uniprot/A0A7N9D8R8 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/9541:RFX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4G0|||http://purl.uniprot.org/uniprot/A0A2K5U4L9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MRPS26 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS26 family.|||Mitochondrion http://togogenome.org/gene/9541:PSIP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF26|||http://purl.uniprot.org/uniprot/G7PSB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HDGF family.|||Nucleus http://togogenome.org/gene/9541:ERGIC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJ70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/9541:FDPS ^@ http://purl.uniprot.org/uniprot/I7GHV0 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9541:PDP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJS8|||http://purl.uniprot.org/uniprot/G7Q1C0 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:STK17B ^@ http://purl.uniprot.org/uniprot/A0A2K5UTS2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:VANGL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RPP30 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTP1 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/9541:PCSK2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YR00|||http://purl.uniprot.org/uniprot/G7PH08 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9541:POLR2J ^@ http://purl.uniprot.org/uniprot/A0A2K5X258 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/9541:ORMDL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9541:DENR ^@ http://purl.uniprot.org/uniprot/A0A2K5TSX6 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/9541:HOXB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:SRP9 ^@ http://purl.uniprot.org/uniprot/G8F5S9|||http://purl.uniprot.org/uniprot/Q4R6I6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP14; binds RNA as heterodimer (By similarity). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). http://togogenome.org/gene/9541:GADL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCW0|||http://purl.uniprot.org/uniprot/G7NYB1 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9541:VAC14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Endosome membrane|||Microsome membrane http://togogenome.org/gene/9541:RNF141 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWB7 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/9541:LOC102144634 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHJ7 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:QPCTL ^@ http://purl.uniprot.org/uniprot/G8F4B6|||http://purl.uniprot.org/uniprot/Q4R942 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutaminyl-peptide cyclotransferase family.|||Golgi apparatus membrane|||It is unclear whether this protein requires a metal cofactor for catalysis. It was originally proposed to be a Zn(2+)-dependent metalloenzyme based on structural similarities to bacterial aminopeptidases and the observation that it can bind Zn(2+) ions, typically in a 1:1 stoichiometry (By similarity). However, a recent study suggests a Zn(2+)-independent catalytic mechanism (By similarity).|||Responsible for the biosynthesis of pyroglutamyl peptides. http://togogenome.org/gene/9541:PUF60 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFX0|||http://purl.uniprot.org/uniprot/A0A2K5VG32|||http://purl.uniprot.org/uniprot/A0A2K5VG43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/9541:INTS14 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/9541:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRA3|||http://purl.uniprot.org/uniprot/A0A7N9DC80 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:PFDN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPQ5|||http://purl.uniprot.org/uniprot/G7PFU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9541:SFXN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:COLGALT2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJM5 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/9541:DNAL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9541:SLC17A3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYE1|||http://purl.uniprot.org/uniprot/G7P2K7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TFE3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBY1|||http://purl.uniprot.org/uniprot/G7Q2P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9541:SNX1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IGR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/9541:RIPPLY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9541:CMTM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5K3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC25A51 ^@ http://purl.uniprot.org/uniprot/A0A7N9CMS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:PSD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVK8 ^@ Subcellular Location Annotation ^@ Membrane|||ruffle membrane http://togogenome.org/gene/9541:MRPL28 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD28 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/9541:PRPF38B ^@ http://purl.uniprot.org/uniprot/A0A2K5UDD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/9541:GNG2 ^@ http://purl.uniprot.org/uniprot/G7PA91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:PRKAB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCL8|||http://purl.uniprot.org/uniprot/G7PIT4 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9541:STEAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W645 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:ALDOB ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5A0|||http://purl.uniprot.org/uniprot/G7PRT5 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/9541:FOXO4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHY7|||http://purl.uniprot.org/uniprot/G7Q2Z4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102119787 ^@ http://purl.uniprot.org/uniprot/G7PCH4|||http://purl.uniprot.org/uniprot/Q4R5B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DPCD ^@ http://purl.uniprot.org/uniprot/A0A2K5TMH4 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/9541:PACSIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/9541:HORMAD1 ^@ http://purl.uniprot.org/uniprot/Q4R8B9 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Interacts with HORMAD2. Interacts with IHO1.|||Nucleus|||Phosphorylated at Ser-377 in a SPO11-dependent manner.|||Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. http://togogenome.org/gene/9541:SSR2 ^@ http://purl.uniprot.org/uniprot/G7NV73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9541:FAM149B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD96 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/9541:SOX30 ^@ http://purl.uniprot.org/uniprot/Q8WNV5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as both a transcriptional activator and repressor (By similarity). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (By similarity). Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (By similarity). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity).|||Cytoplasm|||Interacts with CTNNB1, competitively inhibiting CTNNB1-TCF7L2/TCF4 interaction.|||Nucleus http://togogenome.org/gene/9541:SLITRK3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAS2|||http://purl.uniprot.org/uniprot/G7NZH4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:OGT ^@ http://purl.uniprot.org/uniprot/A0A2K5TWY1|||http://purl.uniprot.org/uniprot/A0A8J8XT42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/9541:TFDP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5US80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:SULF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH45 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:GTPBP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHT5 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/9541:C5AR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IEK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:UBL3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZA0|||http://purl.uniprot.org/uniprot/G7PVY1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:FGF17 ^@ http://purl.uniprot.org/uniprot/A0A2K5V360 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:HARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7T9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:TYR ^@ http://purl.uniprot.org/uniprot/A0A2K5VT29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9541:S100A9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRV3 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:YTHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ42|||http://purl.uniprot.org/uniprot/A0A2K5UZA9|||http://purl.uniprot.org/uniprot/G7P5Q2 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9541:STAC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2G2 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9541:CPA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY88 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:LOC102120647 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0X6 ^@ Similarity ^@ Belongs to the DNAJC25 family. http://togogenome.org/gene/9541:IREB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X545 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Cytoplasm http://togogenome.org/gene/9541:LOC102140281 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVK2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/9541:LPAR1 ^@ http://purl.uniprot.org/uniprot/I7GN66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/9541:FOXJ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAZ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RPL13A ^@ http://purl.uniprot.org/uniprot/I7GKG8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/9541:GRIK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2V7|||http://purl.uniprot.org/uniprot/A0A2K5X344|||http://purl.uniprot.org/uniprot/A0A2K5X351 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:LYN ^@ http://purl.uniprot.org/uniprot/A0A2K5VF55 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:ODR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8C2|||http://purl.uniprot.org/uniprot/A0A2K5V8C9 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/9541:ECRG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2S1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/9541:SERPINE1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4W5|||http://purl.uniprot.org/uniprot/G7P138 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:IDI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKE6 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/9541:PICK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCA7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.|||cytoskeleton|||perinuclear region|||synaptosome http://togogenome.org/gene/9541:GNB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XKZ3|||http://purl.uniprot.org/uniprot/G7PJN5 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9541:LOC101926677 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NECTIN3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGE7 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9541:FAM32A ^@ http://purl.uniprot.org/uniprot/A0A8J8XI49|||http://purl.uniprot.org/uniprot/G7PZQ2 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/9541:PTGES ^@ http://purl.uniprot.org/uniprot/G7PRD3|||http://purl.uniprot.org/uniprot/Q6PWL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAPEG family.|||Homotrimer.|||Membrane|||Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity).|||perinuclear region http://togogenome.org/gene/9541:GRIN2B ^@ http://purl.uniprot.org/uniprot/A0A8J8YJG1|||http://purl.uniprot.org/uniprot/G7PJX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:PSMD9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFE0|||http://purl.uniprot.org/uniprot/G7PJ73 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/9541:HK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U647 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9541:LOC102129291 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8V5|||http://purl.uniprot.org/uniprot/A7XEI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hepcidin family.|||Secreted http://togogenome.org/gene/9541:WASL ^@ http://purl.uniprot.org/uniprot/A0A2K5VG25 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:AQP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:DESI2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2W7 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9541:RIC8B ^@ http://purl.uniprot.org/uniprot/A0A2K5WDJ4|||http://purl.uniprot.org/uniprot/A0A2K5WDN6|||http://purl.uniprot.org/uniprot/A0A2K5WDW8|||http://purl.uniprot.org/uniprot/A0A7N9CPF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/9541:VCAM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UM33 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:PACC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0N5|||http://purl.uniprot.org/uniprot/G7NUL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CA22 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/9541:PDRG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/9541:BLVRA ^@ http://purl.uniprot.org/uniprot/A0A2K5X5P8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.|||Monomer.|||Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.|||cytosol http://togogenome.org/gene/9541:MAT1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WMF0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/9541:SMAD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:POSTN ^@ http://purl.uniprot.org/uniprot/A0A2K5VW02|||http://purl.uniprot.org/uniprot/A0A2K5VW23|||http://purl.uniprot.org/uniprot/A0A2K5VW96|||http://purl.uniprot.org/uniprot/A0A2K5VWG9|||http://purl.uniprot.org/uniprot/G7PW19 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9541:LANCL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVY4|||http://purl.uniprot.org/uniprot/A0A2K5VWA1|||http://purl.uniprot.org/uniprot/A0A979HLA0 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9541:BGN ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ10|||http://purl.uniprot.org/uniprot/G7Q1Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||May be involved in collagen fiber assembly.|||extracellular matrix http://togogenome.org/gene/9541:ZNF449 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPM8|||http://purl.uniprot.org/uniprot/A0A8J8XYN0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:BARX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102117998 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CCN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJS4|||http://purl.uniprot.org/uniprot/G7PD02 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:MPC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT03|||http://purl.uniprot.org/uniprot/G8F4T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DCST2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:THG1L ^@ http://purl.uniprot.org/uniprot/A0A2K5VWY9|||http://purl.uniprot.org/uniprot/A0A8J8XA90 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/9541:LOC102131133 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE79|||http://purl.uniprot.org/uniprot/G7P6C8 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TNFRSF14 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0R1|||http://purl.uniprot.org/uniprot/A0A7N9CGR4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:EGFL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CENPH ^@ http://purl.uniprot.org/uniprot/A0A2K5W8L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/9541:GPR52 ^@ http://purl.uniprot.org/uniprot/G8F2R8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:STX3 ^@ http://purl.uniprot.org/uniprot/A0A7N9C9E6 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:CA8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8M9 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/9541:DLD ^@ http://purl.uniprot.org/uniprot/A0A2K5TZW4|||http://purl.uniprot.org/uniprot/Q60HG3 ^@ Cofactor|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2) and DLD (dihydrolipoamide dehydrogenase; E3). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX.|||Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity).|||Mitochondrion matrix|||Nucleus|||The active site is a redox-active disulfide bond.|||Tyrosine phosphorylated.|||acrosome|||flagellum http://togogenome.org/gene/9541:LOC101925125 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin basic protein family.|||Myelin membrane http://togogenome.org/gene/9541:WNT7A ^@ http://purl.uniprot.org/uniprot/G7NYG1|||http://purl.uniprot.org/uniprot/Q1KYK9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Wnt family.|||Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD5. Interacts with PORCN (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity).|||Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity).|||Ligand for members of the frizzled family of seven transmembrane receptors.|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.|||extracellular matrix http://togogenome.org/gene/9541:TMEM39A ^@ http://purl.uniprot.org/uniprot/A0A2K5WRG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9541:LOC101866572 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUS6|||http://purl.uniprot.org/uniprot/G8F5P9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PSMC5 ^@ http://purl.uniprot.org/uniprot/I7G7U1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:TSPAN6 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y336|||http://purl.uniprot.org/uniprot/G7Q377 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:PIK3R3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJZ8 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9541:MYADM ^@ http://purl.uniprot.org/uniprot/A0A2K5UNG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAL family.|||Membrane http://togogenome.org/gene/9541:CLCN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMS8|||http://purl.uniprot.org/uniprot/G7Q273 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/9541:CEBPE ^@ http://purl.uniprot.org/uniprot/A0A7N9D2L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/9541:TMEM229B ^@ http://purl.uniprot.org/uniprot/A0A2K5UEI4|||http://purl.uniprot.org/uniprot/A0A7N9D440 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/9541:IFITM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3Q2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:YIPF5 ^@ http://purl.uniprot.org/uniprot/Q4R5M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YIP1 family.|||COPII-coated vesicle|||Endoplasmic reticulum membrane|||Interacts with the COPII coat components Sec23 (SEC23A and/or SEC23B) and Sec24 (SEC24A and/or SEC24B) (By similarity). Interacts with YIF1A (By similarity). May interact with RAB1A (By similarity). Interacts with YIPF3 and YIPF4 (By similarity).|||Plays a role in transport between endoplasmic reticulum and Golgi. In pancreatic beta cells, required to transport proinsulin from endoplasmic reticulum into the Golgi.|||cis-Golgi network membrane http://togogenome.org/gene/9541:IGBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIE3 ^@ Similarity ^@ Belongs to the IGBP1/TAP42 family. http://togogenome.org/gene/9541:BCOR ^@ http://purl.uniprot.org/uniprot/A0A2K5W0P1 ^@ Similarity ^@ Belongs to the BCOR family. http://togogenome.org/gene/9541:ESR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2L5|||http://purl.uniprot.org/uniprot/A0A8J8Y5F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9541:AGPAT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YED8|||http://purl.uniprot.org/uniprot/G7P2Q6 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9541:TNFSF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTN0|||http://purl.uniprot.org/uniprot/A0A7N9CLL2 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:RIOX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVK1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family. MINA53 subfamily.|||Binds 1 Fe(2+) ion per subunit.|||Nucleus|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. http://togogenome.org/gene/9541:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/9541:DPEP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YK92|||http://purl.uniprot.org/uniprot/G7PZZ9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9541:LRRC8A ^@ http://purl.uniprot.org/uniprot/A0A2K5VRD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZK5|||http://purl.uniprot.org/uniprot/G7NZQ2 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9541:NPY ^@ http://purl.uniprot.org/uniprot/A0A2K5VHQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9541:ANKRD13B ^@ http://purl.uniprot.org/uniprot/A0A2K5TXT8 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/9541:LOC102129218 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQC6|||http://purl.uniprot.org/uniprot/G7P6I7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:UPF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ20 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:EPHB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V953 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:BTG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJW1 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:SERPINB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAJ6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:GHRL ^@ http://purl.uniprot.org/uniprot/A0A2K5VHC7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the motilin family.|||Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.|||O-octanoylation is essential for ghrelin activity.|||Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.|||Secreted http://togogenome.org/gene/9541:LOC102121958 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:FAM163A ^@ http://purl.uniprot.org/uniprot/A0A8J8YA09|||http://purl.uniprot.org/uniprot/G7NU05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/9541:LMBR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYG8 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/9541:AGPAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF11 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/9541:IFNGR1 ^@ http://purl.uniprot.org/uniprot/G7P327 ^@ Similarity ^@ Belongs to the type II cytokine receptor family. http://togogenome.org/gene/9541:CERT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6D8|||http://purl.uniprot.org/uniprot/G7P7R6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/9541:CLDN16 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:TMEM106B ^@ http://purl.uniprot.org/uniprot/A0A2K5W4F7 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9541:SLITRK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPB1 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/9541:CA11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZV3|||http://purl.uniprot.org/uniprot/G7PY41 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/9541:NDUFS2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CR31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 49 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SLC17A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WED2|||http://purl.uniprot.org/uniprot/G8F4T4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102137997 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN85 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:MYC ^@ http://purl.uniprot.org/uniprot/G7PCT8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:LHFPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8R0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RGS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7U7 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/9541:SLC5A7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YA03|||http://purl.uniprot.org/uniprot/G7PMW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PTGR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQJ4|||http://purl.uniprot.org/uniprot/A0A7N9DCK9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9541:LOC102141626 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIP2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CA12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSA5|||http://purl.uniprot.org/uniprot/A0A2K5TSB2|||http://purl.uniprot.org/uniprot/A0A7N9IEH5 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:HDHD3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNL2|||http://purl.uniprot.org/uniprot/G7PRM3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/9541:TMEM135 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane http://togogenome.org/gene/9541:ACTN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIN2 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9541:POLR3A ^@ http://purl.uniprot.org/uniprot/A0A8J8YMI0|||http://purl.uniprot.org/uniprot/G7PEY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9541:UNC5D ^@ http://purl.uniprot.org/uniprot/A0A2K5X484|||http://purl.uniprot.org/uniprot/A0A2K5X486 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9541:HNRNPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0Q6 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/9541:LOC101865922 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0B2|||http://purl.uniprot.org/uniprot/I7GLL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9541:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYQ9|||http://purl.uniprot.org/uniprot/A0A2K5WYZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/9541:CHN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZQ2 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/9541:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:CPB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX20 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:DEFB119 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG20|||http://purl.uniprot.org/uniprot/A0A2K5VG64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:AQP9 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8Y4|||http://purl.uniprot.org/uniprot/G7PBK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:BRF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y646|||http://purl.uniprot.org/uniprot/G7PD66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:USO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH1|||http://purl.uniprot.org/uniprot/A0A2K5WJK0|||http://purl.uniprot.org/uniprot/A0A7N9CYF0|||http://purl.uniprot.org/uniprot/G7P562 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VDP/USO1/EDE1 family.|||Membrane http://togogenome.org/gene/9541:MRPL27 ^@ http://purl.uniprot.org/uniprot/A0A7N9CWB8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/9541:FAM174A ^@ http://purl.uniprot.org/uniprot/A0A2K5V3R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9541:PEX5 ^@ http://purl.uniprot.org/uniprot/G7PJP8 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9541:PAFAH1B1 ^@ http://purl.uniprot.org/uniprot/Q8HXX0 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity. Interacts with the catalytic dimer of PAF-AH (I) heterotetrameric enzyme: interacts with PAFAH1B2 homodimer (alpha2/alpha2 homodimer), PAFAH1B3 homodimer (alpha1/alpha1 homodimer) and PAFAH1B2-PAFAH1B3 heterodimer (alpha2/alpha1 heterodimer) (By similarity). Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Interacts with INTS13. Interacts with DCDC1.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Nucleus membrane|||Originally the subunits of the type I platelet-activating factor (PAF) acetylhydrolase was named alpha (PAFAH1B1), beta (PAFAH1B2) and gamma (PAFAH1B3) (By similarity). Now these subunits have been renamed beta (PAFAH1B1), alpha2 (PAFAH1B2) and alpha1 (PAFAH1B3) respectively (By similarity).|||Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity).|||centrosome|||cytoskeleton|||spindle http://togogenome.org/gene/9541:SLC45A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQN9|||http://purl.uniprot.org/uniprot/Q95KI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.|||Membrane|||Proton-associated sucrose transporter. May be able to transport also glucose and fructose. http://togogenome.org/gene/9541:HOXB13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9541:FOXN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWB7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FUT9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZV7|||http://purl.uniprot.org/uniprot/G7P425 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:FOXR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQV5|||http://purl.uniprot.org/uniprot/G8F4L6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ATP5MG ^@ http://purl.uniprot.org/uniprot/A0A7N9DCI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/9541:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W121 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9541:TLR2 ^@ http://purl.uniprot.org/uniprot/Q95M53 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).|||Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.|||Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.|||In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.|||Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).|||Membrane|||Membrane raft|||The ATG16L1-binding motif mediates interaction with ATG16L1.|||Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.|||phagosome membrane http://togogenome.org/gene/9541:TFR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PLPPR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:CYSTM1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIF1|||http://purl.uniprot.org/uniprot/A0A8J8XDV0|||http://purl.uniprot.org/uniprot/G7P8G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYSTM1 family.|||Membrane http://togogenome.org/gene/9541:LSM14B ^@ http://purl.uniprot.org/uniprot/A0A2K5WW67|||http://purl.uniprot.org/uniprot/A0A2K5WWR6 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/9541:BDKRB1 ^@ http://purl.uniprot.org/uniprot/Q3BCU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.|||Cell membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/9541:B3GNT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEF2|||http://purl.uniprot.org/uniprot/G7PMA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:LOC102124950 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9541:FLNB ^@ http://purl.uniprot.org/uniprot/A0A2K5WH26|||http://purl.uniprot.org/uniprot/A0A2K5WHB3 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/9541:ZER1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPV2|||http://purl.uniprot.org/uniprot/G7PRE8 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/9541:NUP93 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1A6|||http://purl.uniprot.org/uniprot/G7Q166|||http://purl.uniprot.org/uniprot/Q4R8S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/9541:MEGF8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIM4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NGDN ^@ http://purl.uniprot.org/uniprot/A0A2K5V852 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:CMTR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZK3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with POLR2A (via C-terminus).|||Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/9541:ANAPC15 ^@ http://purl.uniprot.org/uniprot/G7PR12 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/9541:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL09 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZG2|||http://purl.uniprot.org/uniprot/A0A2K5TZH0|||http://purl.uniprot.org/uniprot/A0A2K5TZL5|||http://purl.uniprot.org/uniprot/A0A2K5TZN3|||http://purl.uniprot.org/uniprot/A0A7N9IBX7|||http://purl.uniprot.org/uniprot/A0A7N9IEM6|||http://purl.uniprot.org/uniprot/G8F3J7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/9541:HOXA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:TMEM41A ^@ http://purl.uniprot.org/uniprot/A0A2K5WJR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM41 family.|||Membrane http://togogenome.org/gene/9541:ECHDC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0C9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:RAG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/9541:SEPTIN10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSH9|||http://purl.uniprot.org/uniprot/A0A2K5VSK9|||http://purl.uniprot.org/uniprot/A0A2K5VSL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:THTPA ^@ http://purl.uniprot.org/uniprot/A0A2K5VF89 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Hydrolase highly specific for thiamine triphosphate (ThTP).|||Monomer. http://togogenome.org/gene/9541:EBAG9 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB51 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/9541:AK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/9541:CDIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9541:MARK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4F5|||http://purl.uniprot.org/uniprot/A0A2K5V4G4|||http://purl.uniprot.org/uniprot/A0A2K5V4J1|||http://purl.uniprot.org/uniprot/A0A2K5V4L6|||http://purl.uniprot.org/uniprot/A0A7N9DD34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9541:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN47 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9541:KLC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9541:STN1 ^@ http://purl.uniprot.org/uniprot/G7PDW8|||http://purl.uniprot.org/uniprot/Q4R804 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity).|||Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with TEN1 and CTC1. Interacts with ACD/TPP1, POT1 and POLA1.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/9541:SPATS2L ^@ http://purl.uniprot.org/uniprot/A0A2K5WAB6 ^@ Similarity ^@ Belongs to the SPATS2 family. http://togogenome.org/gene/9541:NRBP1 ^@ http://purl.uniprot.org/uniprot/Q4R8X0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Endomembrane system|||Homodimer (By similarity). Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1 (By similarity). Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity). Interacts with ELOC/TCEB1, ELOB/TCEB2, TSC22D2 and TSC22D4 (By similarity). Interacts with the Elongin BC E3 ubiquitin ligase complex via its interaction with ELOB/TCEB2 and ELOC/TCEB1 (By similarity). Interacts with SALL4 (By similarity).|||Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (By similarity).|||The protein kinase domain is predicted to be catalytically inactive.|||cell cortex|||lamellipodium http://togogenome.org/gene/9541:SPTBN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAC7 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/9541:GALNTL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:MTFP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHQ5|||http://purl.uniprot.org/uniprot/G7PF69 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/9541:KCNJ16 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCS8|||http://purl.uniprot.org/uniprot/A0A8J8XNL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:TXLNA ^@ http://purl.uniprot.org/uniprot/A0A2K5U644|||http://purl.uniprot.org/uniprot/G8F3T7 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9541:PHACTR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D260 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9541:DEFB132 ^@ http://purl.uniprot.org/uniprot/A4H265|||http://purl.uniprot.org/uniprot/G7PGQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:PLAC8L1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRF4|||http://purl.uniprot.org/uniprot/G7P8K5 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/9541:SYPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:FGF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF43|||http://purl.uniprot.org/uniprot/A0A8J8Y8K5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:LOC102128529 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPI1|||http://purl.uniprot.org/uniprot/G7P1L2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:TNR ^@ http://purl.uniprot.org/uniprot/A0A2K5TRR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/9541:TSSK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPA4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:HMBOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9Z2|||http://purl.uniprot.org/uniprot/A0A2K5V9Z7|||http://purl.uniprot.org/uniprot/A0A7N9D4V8|||http://purl.uniprot.org/uniprot/G7PD48 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TMEM19 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/9541:ENTPD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSX2 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:SLC35A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U963 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:GAP43 ^@ http://purl.uniprot.org/uniprot/Q25G41|||http://purl.uniprot.org/uniprot/Q95K78 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Cell membrane|||Cytoplasm|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts (via IQ domain) with calmodulin (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Membrane|||Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity).|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Perikaryon|||Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||axon|||dendrite|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/9541:WDR82 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/9541:TCTA ^@ http://purl.uniprot.org/uniprot/A0A2K5W833|||http://purl.uniprot.org/uniprot/G8F3M0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane http://togogenome.org/gene/9541:HNRNPK ^@ http://purl.uniprot.org/uniprot/A0A2K5TNW0|||http://purl.uniprot.org/uniprot/Q4R4M6 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Identified in the spliceosome C complex. Interacts with ANKRD28, RBM42 and ZIK1. Interacts with DDX1. Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with p53/TP53. Interacts with BRDT (By similarity). Interacts with IVNS1ABP (By similarity). Interacts with PPIA/CYPA (By similarity). Part of a transcription inhibitory ribonucleoprotein complex composed at least of the circular RNA circZNF827, ZNF827 and HNRNPL (By similarity).|||O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.|||One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).|||Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions (By similarity).|||Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination (By similarity).|||nucleoplasm|||podosome http://togogenome.org/gene/9541:ADGB ^@ http://purl.uniprot.org/uniprot/A0A2K5V9S6 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SAMD4B ^@ http://purl.uniprot.org/uniprot/A0A8J8YSU4|||http://purl.uniprot.org/uniprot/G7PXJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm http://togogenome.org/gene/9541:GLIPR1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUU6 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/9541:CALHM5 ^@ http://purl.uniprot.org/uniprot/A0A7N9CK87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:EIF5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WME8|||http://purl.uniprot.org/uniprot/A0A2K5WMF8|||http://purl.uniprot.org/uniprot/G8F5Y2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/9541:TRIM25 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9541:CYSLTR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9C8W6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9A9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:HOXC8 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y903|||http://purl.uniprot.org/uniprot/G7PHW1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:NDUFAF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBD3 ^@ Similarity ^@ Belongs to the complex I NDUFA12 subunit family. http://togogenome.org/gene/9541:ADPRM ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5L1|||http://purl.uniprot.org/uniprot/G7PTN6 ^@ Similarity|||Subunit ^@ Belongs to the ADPRibase-Mn family.|||Monomer. http://togogenome.org/gene/9541:AQP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:PPP4R3B ^@ http://purl.uniprot.org/uniprot/A0A2K5WJE9|||http://purl.uniprot.org/uniprot/A0A2K5WJI2|||http://purl.uniprot.org/uniprot/A0A8J8XJ84|||http://purl.uniprot.org/uniprot/G7PM87 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9541:NOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF08|||http://purl.uniprot.org/uniprot/A0A8J8XXT4|||http://purl.uniprot.org/uniprot/G7Q381 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NDUFV2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2C7|||http://purl.uniprot.org/uniprot/G7PWD9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/9541:IRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9541:LOC102137003 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCC3 family.|||Membrane|||Mitochondrion inner membrane|||Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. http://togogenome.org/gene/9541:PLG ^@ http://purl.uniprot.org/uniprot/A0A2K5TJJ6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.|||Secreted http://togogenome.org/gene/9541:RPS26 ^@ http://purl.uniprot.org/uniprot/P61251 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS26 family.|||Component of the 40S small ribosomal subunit.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9541:FAM118A ^@ http://purl.uniprot.org/uniprot/A0A2K5V3F1|||http://purl.uniprot.org/uniprot/A0A7N9CQ53 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9541:NOP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB95 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/9541:DCLRE1C ^@ http://purl.uniprot.org/uniprot/A0A2K5X8W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/9541:LOC102117971 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG48 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:HMCES ^@ http://purl.uniprot.org/uniprot/A0A2K5V147 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/9541:OXCT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/9541:SLC35A3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CEN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/9541:TOP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1H4 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/9541:CMC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQX3 ^@ Similarity ^@ Belongs to the CMC4 family. http://togogenome.org/gene/9541:C19H19orf54 ^@ http://purl.uniprot.org/uniprot/A0A2K5W917|||http://purl.uniprot.org/uniprot/A0A7N9CGI7 ^@ Similarity ^@ Belongs to the ACTMAP family. http://togogenome.org/gene/9541:AIFM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6Q3|||http://purl.uniprot.org/uniprot/A0A7N9CDH0|||http://purl.uniprot.org/uniprot/A0A8J8YM33 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase family. http://togogenome.org/gene/9541:RXFP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN45 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102137625 ^@ http://purl.uniprot.org/uniprot/G7P2L6|||http://purl.uniprot.org/uniprot/G7P2P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:EXOC6B ^@ http://purl.uniprot.org/uniprot/A0A2K5V5C6|||http://purl.uniprot.org/uniprot/A0A7N9CB83 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9541:LYPD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0X5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:GPR33 ^@ http://purl.uniprot.org/uniprot/A0A7N9CK82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:IP6K3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQF7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9541:EIF4G3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAD7 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9541:TRPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8P8|||http://purl.uniprot.org/uniprot/G7P008 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.|||Membrane|||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. http://togogenome.org/gene/9541:LOC102125088 ^@ http://purl.uniprot.org/uniprot/A0A2K5UME9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/9541:DEFB1 ^@ http://purl.uniprot.org/uniprot/P61261 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-defensin family.|||Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.|||Membrane|||Monomer. Homodimer.|||Secreted http://togogenome.org/gene/9541:DHDDS ^@ http://purl.uniprot.org/uniprot/A0A2K5TPV3|||http://purl.uniprot.org/uniprot/A0A2K5TPX8 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/9541:BTK ^@ http://purl.uniprot.org/uniprot/A0A2K5VDZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9541:LOC102134014 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBG0|||http://purl.uniprot.org/uniprot/A0A2K5UH45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9541:CEBPG ^@ http://purl.uniprot.org/uniprot/A0A2K5UNS1 ^@ Similarity ^@ Belongs to the bZIP family. C/EBP subfamily. http://togogenome.org/gene/9541:LOC102123677 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7N1|||http://purl.uniprot.org/uniprot/A0A2K5W7P1|||http://purl.uniprot.org/uniprot/A0A7N9DHH8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/9541:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5D7 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:THOC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7V1|||http://purl.uniprot.org/uniprot/A0A2K5U7V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/9541:NFYB ^@ http://purl.uniprot.org/uniprot/A0A2K5TK75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/9541:PPY ^@ http://purl.uniprot.org/uniprot/A0A2K5TNU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/9541:LOC102134628 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS51 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9541:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9H7|||http://purl.uniprot.org/uniprot/G7P0P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9541:KIN ^@ http://purl.uniprot.org/uniprot/A0A2K5U197 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/9541:PLK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9E4 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||centriole http://togogenome.org/gene/9541:IL13RA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily.|||Membrane http://togogenome.org/gene/9541:PPARA ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0L9|||http://purl.uniprot.org/uniprot/G7PFY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.|||Nucleus http://togogenome.org/gene/9541:LOC102146966 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJM6|||http://purl.uniprot.org/uniprot/A0A7N9CDA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PHKG2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CTB8 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/9541:MLF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V446 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/9541:IFT20 ^@ http://purl.uniprot.org/uniprot/G7PTW5 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/9541:FAM234B ^@ http://purl.uniprot.org/uniprot/A0A2K5TQD1 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/9541:PIK3CD ^@ http://purl.uniprot.org/uniprot/A0A7N9CY41 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:LOC102120132 ^@ http://purl.uniprot.org/uniprot/A0A0S4XKM2|||http://purl.uniprot.org/uniprot/Q4W7C7 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9541:RIC8A ^@ http://purl.uniprot.org/uniprot/Q4R720 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cell membrane|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).|||Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1. Interacts with NCS1; interaction is favored in the absence of Ca(2+) and myristoylation of NCS1 is not required (By similarity). http://togogenome.org/gene/9541:SRM ^@ http://purl.uniprot.org/uniprot/A0A2K5WDB1 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9541:RTBDN ^@ http://purl.uniprot.org/uniprot/A0A7N9IFF7 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9541:RHOT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGS5|||http://purl.uniprot.org/uniprot/A0A2K5WGS8|||http://purl.uniprot.org/uniprot/A0A2K5WGT8|||http://purl.uniprot.org/uniprot/A0A7N9CW05|||http://purl.uniprot.org/uniprot/A0A8J8Y5N8|||http://purl.uniprot.org/uniprot/G7PU10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:FCF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/9541:NUP107 ^@ http://purl.uniprot.org/uniprot/A0A2K5V237 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/9541:LOC102124022 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TYROBP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HNRNPD ^@ http://purl.uniprot.org/uniprot/A0A2K5UXA5|||http://purl.uniprot.org/uniprot/A0A2K5UXI0|||http://purl.uniprot.org/uniprot/A0A7N9DEU8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ATG3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPG7|||http://purl.uniprot.org/uniprot/G7NZS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG3 family.|||Cytoplasm http://togogenome.org/gene/9541:ATL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X807 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9541:ODF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBQ3|||http://purl.uniprot.org/uniprot/G8F3R8 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/9541:RPE ^@ http://purl.uniprot.org/uniprot/A0A7N9CE89 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/9541:JAKMIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCL5 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9541:CCKAR ^@ http://purl.uniprot.org/uniprot/A0A2K5WAE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9541:TMEM255A ^@ http://purl.uniprot.org/uniprot/A0A2K5TMD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/9541:CAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TRAPPC6B ^@ http://purl.uniprot.org/uniprot/A0A2K5TTI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||cis-Golgi network http://togogenome.org/gene/9541:NKX2-2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EPHA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6J5|||http://purl.uniprot.org/uniprot/A0A2K5W6J6|||http://purl.uniprot.org/uniprot/A0A2K5W6M9|||http://purl.uniprot.org/uniprot/A0A7N9D0P2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:IDH3A ^@ http://purl.uniprot.org/uniprot/A0A2K5TMV7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/9541:SLC25A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:ANP32B ^@ http://purl.uniprot.org/uniprot/A0A2K5V4N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANP32 family.|||Multifunctional protein that is involved in the regulation of many processes.|||Nucleus http://togogenome.org/gene/9541:EPHX1 ^@ http://purl.uniprot.org/uniprot/G8F5S8|||http://purl.uniprot.org/uniprot/Q2PG24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/9541:PROK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9541:LOC102145248 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5X5 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/9541:SLC52A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSG3|||http://purl.uniprot.org/uniprot/G8F5V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/9541:KAT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9541:KCNH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X943|||http://purl.uniprot.org/uniprot/A0A2K5X9I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:BTF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8X8 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9541:CD40 ^@ http://purl.uniprot.org/uniprot/A0A2K5V585 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN28|||http://purl.uniprot.org/uniprot/A0A2K5UN41 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:STEAP4 ^@ http://purl.uniprot.org/uniprot/G7P1V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:GDI1 ^@ http://purl.uniprot.org/uniprot/A0A158SIP6|||http://purl.uniprot.org/uniprot/Q8HXX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Interacts with RHOH (By similarity). Interacts with the non-phosphorylated forms of RAB1A, RAB3A, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (By similarity).|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.|||Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes (By similarity).|||trans-Golgi network http://togogenome.org/gene/9541:NSG1 ^@ http://purl.uniprot.org/uniprot/Q4R5Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSG family.|||Cytoplasmic vesicle membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Forms a complex with GRIP1, GRIA2 and STX12 through direct interaction with GRIP1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. Interacts with STX12 (By similarity). Interacts with APP; could regulate APP processing (By similarity). Interacts with FAM171A1 (By similarity).|||Golgi stack membrane|||Late endosome membrane|||Lysosome lumen|||Membrane|||Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity).|||Recycling endosome membrane|||dendrite|||multivesicular body membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:SNAPIN ^@ http://purl.uniprot.org/uniprot/A0A2K5W620 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPIN family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.|||synaptic vesicle membrane http://togogenome.org/gene/9541:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D8M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:APOC3 ^@ http://purl.uniprot.org/uniprot/P18659 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C3 family.|||Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.|||Secreted|||The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. http://togogenome.org/gene/9541:UPF3B ^@ http://purl.uniprot.org/uniprot/A0A2K5VTM2|||http://purl.uniprot.org/uniprot/A0A2K5VTM6 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/9541:GKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYX9 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/9541:ARGLU1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9C1|||http://purl.uniprot.org/uniprot/G7PVP8 ^@ Similarity ^@ Belongs to the UPF0430 family. http://togogenome.org/gene/9541:CNIH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9541:FOXP3 ^@ http://purl.uniprot.org/uniprot/Q6U8D7 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Acetylation is mediated by a coordinated action of KAT5 and EP300/p300 acetyltransferases: EP300/p300 is required to enhance KAT5 autoacetylation, promoting acetylation of FOXP3 by KAT5. Deacetylated by SIRT1.|||Cytoplasm|||Homodimer. Dimerization is essential for its transcriptional regulator activity. Interacts with IKZF3. Interacts (via LXXLL motif) with RORA (via AF-2 motif). Interacts with HDAC9 in the absence of T-cell stimulation. Interacts with PPP1CA, PPP1CB, PPP1CG, KAT5, HDAC7, HSPA8, USP7, STUB1, HSPA1A/B, RUNX1, RUNX2, RUNX3, RELA, NFATC2, IKFZ4 and RORC.|||Nucleus|||Phosphorylation at Ser-418 regulates its transcriptional repressor activity and consequently, regulatory T-cells (Treg) suppressive function. Phosphorylation by CDK2 negatively regulates its transcriptional activity and protein stability.|||Polyubiquitinated, leading to its proteasomal degradation in regulatory T-cells (Treg) which is mediated by STUB1 in a HSPA1A/B-dependent manner. Deubiquitinated by USP7 and USP44 leading to increase in protein stability.|||The fork-head DNA-binding domain is essential for its dimerization and interaction with NFATC2.|||Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7. Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development. Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).|||Undergoes proteolytic cleavage in activated regulatory T-cells (Treg), and can be cleaved at either the N- or C-terminal site, or at both sites. http://togogenome.org/gene/9541:AP3M1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTF2|||http://purl.uniprot.org/uniprot/A0A8J8YQP0|||http://purl.uniprot.org/uniprot/G7PEZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/9541:IPO11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA88 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:MAGOH ^@ http://purl.uniprot.org/uniprot/A0A8J8XPY4|||http://purl.uniprot.org/uniprot/G7NVQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9541:GPR89A ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/9541:ACP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSQ4 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/9541:CLCN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX41 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:EXOC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2F7 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9541:GHSR ^@ http://purl.uniprot.org/uniprot/A0A2K5WND3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ITGA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXK0|||http://purl.uniprot.org/uniprot/G8F2Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:SNRPE ^@ http://purl.uniprot.org/uniprot/A0A2K5WYY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9541:KRT20 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4V1|||http://purl.uniprot.org/uniprot/G7PUQ1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC102134935 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGF4|||http://purl.uniprot.org/uniprot/A0A2K5VGH4 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9541:CDC26 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAK7|||http://purl.uniprot.org/uniprot/G7PRM8 ^@ Function|||Similarity ^@ Belongs to the CDC26 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. http://togogenome.org/gene/9541:DYNLT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8A7 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9541:LYRM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA91 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9541:BCKDHA ^@ http://purl.uniprot.org/uniprot/Q8HXY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BCKDHA family.|||Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.|||Mitochondrion matrix|||Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. http://togogenome.org/gene/9541:SERBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0J0|||http://purl.uniprot.org/uniprot/A0A7N9CX01|||http://purl.uniprot.org/uniprot/Q4R9B2 ^@ Similarity ^@ Belongs to the SERBP1-HABP4 family. http://togogenome.org/gene/9541:CASQ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/9541:COQ9 ^@ http://purl.uniprot.org/uniprot/A0A7N9D679 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/9541:WASF3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIG2|||http://purl.uniprot.org/uniprot/G7PVW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9541:EIF4H ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ19 ^@ Function|||Subcellular Location Annotation ^@ Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.|||perinuclear region http://togogenome.org/gene/9541:GGPS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIY0|||http://purl.uniprot.org/uniprot/G7NXI9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9541:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHD1|||http://purl.uniprot.org/uniprot/A0A2K5WHI5|||http://purl.uniprot.org/uniprot/A0A2K5WHL3|||http://purl.uniprot.org/uniprot/A0A2K5WHN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9541:ARSI ^@ http://purl.uniprot.org/uniprot/A0A2K5WH83 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9541:C9 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2W7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/9541:NAT1 ^@ http://purl.uniprot.org/uniprot/A0A4Y1K7V2 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/9541:RAP2C ^@ http://purl.uniprot.org/uniprot/A0A2K5V0X8|||http://purl.uniprot.org/uniprot/G8F3L7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9541:NTRK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS06|||http://purl.uniprot.org/uniprot/A0A2K5VS28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9541:HDAC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGF8|||http://purl.uniprot.org/uniprot/A0A2K5VGP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/9541:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7W9|||http://purl.uniprot.org/uniprot/A0A2K5U7X0|||http://purl.uniprot.org/uniprot/A0A2K5U820 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:DEUP1 ^@ http://purl.uniprot.org/uniprot/G7PNG4|||http://purl.uniprot.org/uniprot/Q95JK1 ^@ Function|||Sequence Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CEP63 family.|||Contaminating sequence. Potential poly-A sequence. The C-terminus was extended based on orthologous sequences.|||Cytoplasm|||Interacts with CEP152; the interaction is mutually exclusive with CEP63.|||Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). http://togogenome.org/gene/9541:FAM13B ^@ http://purl.uniprot.org/uniprot/A0A2K5X739|||http://purl.uniprot.org/uniprot/A0A2K5X7D0|||http://purl.uniprot.org/uniprot/G7P8D3 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9541:PAQR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CAMSAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVP2|||http://purl.uniprot.org/uniprot/A0A2K5WVP7 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/9541:DLX3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFU8|||http://purl.uniprot.org/uniprot/G7PU96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9541:ERRFI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNH5 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/9541:ITPR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W261|||http://purl.uniprot.org/uniprot/A0A2K5W2H1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/9541:AARS1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CCE8 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/9541:GRID2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:LOC102126012 ^@ http://purl.uniprot.org/uniprot/A0A2K5U824 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:DRD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEQ4|||http://purl.uniprot.org/uniprot/G7P6Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|||Membrane|||dendritic spine http://togogenome.org/gene/9541:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A7N9ICC4|||http://purl.uniprot.org/uniprot/A0A8J8XW05|||http://purl.uniprot.org/uniprot/G7P8J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/9541:RHOXF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM98 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPA7 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9541:HSPA8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNF9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9541:MSMB ^@ http://purl.uniprot.org/uniprot/A0A2K5WFL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9541:IL17F ^@ http://purl.uniprot.org/uniprot/A0A8J8XMV3|||http://purl.uniprot.org/uniprot/G7P4V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9541:LOC102127751 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYJ1|||http://purl.uniprot.org/uniprot/A0A2K5VYL2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9541:SUPT16H ^@ http://purl.uniprot.org/uniprot/A0A2K5VAC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/9541:DGKA ^@ http://purl.uniprot.org/uniprot/A0A8J8XJW0|||http://purl.uniprot.org/uniprot/G7PIF8 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic diacylglycerol kinase family.|||Monomer. http://togogenome.org/gene/9541:LOC102130423 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDR5|||http://purl.uniprot.org/uniprot/G8F456 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/9541:LOC102117077 ^@ http://purl.uniprot.org/uniprot/Q8MHW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/9541:MAD1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQN7|||http://purl.uniprot.org/uniprot/A0A2K5WQR5 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/9541:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWA3 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9541:EDIL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYU3|||http://purl.uniprot.org/uniprot/A0A2K5WYV1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DPF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8E9 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/9541:PPIL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSL3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:ARL3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/9541:RNF13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PRKAR2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WX89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TMEM43 ^@ http://purl.uniprot.org/uniprot/A0A7N9I9H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/9541:RHBDD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HOXB7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEE4|||http://purl.uniprot.org/uniprot/G7PU75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:EFHC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ25 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9541:ATP6V1D ^@ http://purl.uniprot.org/uniprot/Q4R702 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||cilium|||clathrin-coated vesicle membrane http://togogenome.org/gene/9541:RHBDD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7I5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GALNT10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SPATS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZX1 ^@ Similarity ^@ Belongs to the SPATS2 family. http://togogenome.org/gene/9541:PTGFR ^@ http://purl.uniprot.org/uniprot/A0A7N9D088 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:UBA52 ^@ http://purl.uniprot.org/uniprot/P0C273 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.|||Cytoplasm|||Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.|||Nucleus|||Part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).|||Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.|||Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins eL40 and eS31, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. http://togogenome.org/gene/9541:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5USQ3|||http://purl.uniprot.org/uniprot/A0A2K5USX5|||http://purl.uniprot.org/uniprot/A0A2K5UT06|||http://purl.uniprot.org/uniprot/A0A2K5UT88|||http://purl.uniprot.org/uniprot/I7GK41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9541:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5R5|||http://purl.uniprot.org/uniprot/A0A2K5W5V0|||http://purl.uniprot.org/uniprot/A0A8J8YCL6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:LETM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XD20|||http://purl.uniprot.org/uniprot/G7PD74 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:GTF2B ^@ http://purl.uniprot.org/uniprot/A0A805PTU9|||http://purl.uniprot.org/uniprot/Q4R3J5 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation.|||Belongs to the TFIIB family.|||Chromosome|||Found in a ternary complex with TATA box-bound TBP. Part of a TFIID-containing RNA polymerase II pre-initiation complex (PIC) that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Associates with TFIID-TFIIA (DA complex) to form TFIID-TFIIA-TFIIB (DAB complex), which is then recognized by RNA polymerase II (Pol II). Found in a RNA polymerase II initiation complex. Interacts (via C-terminus) with TBP; this interaction with TATA box-bound TBP guides Pol II into the PIC. Interacts (via N-terminus) with Pol II. Interacts (via C-terminus) with SSU72; this interaction is inhibited by SYMPK. Interacts with NR2F1; this interaction is direct. Interacts with PGR. Interacts with ESR1. Interacts with GTF2F1 (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2. Interacts with GTF2F2 (via N-terminus); this interaction is inhibited in presence of GTF2F1. Interacts with the transcription elongation factor TCEA2. Interacts with HSF1 (via transactivation domain) (By similarity). Interacts with GPBP1 (By similarity).|||General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Exhibits also autoacetyltransferase activity that contributes to the activated transcription.|||Nucleus|||The TFIIB-type zinc-binding domain is necessary for the interaction and recruitment of RNA polymerase II to the core promoter, the formation of a fully competent pre-initiation complex (PIC) assembly and basal transcription initiation. The C-terminus is necessary and sufficient for interaction with the TATA box-bound TBP complex and for the formation of PIC. http://togogenome.org/gene/9541:MEIS2 ^@ http://purl.uniprot.org/uniprot/I7GEN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9541:SLC27A4 ^@ http://purl.uniprot.org/uniprot/Q4R3Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Endoplasmic reticulum membrane|||Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (By similarity). Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis (By similarity). Probably involved in fatty acid transport across the blood barrier (By similarity). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). http://togogenome.org/gene/9541:GRN ^@ http://purl.uniprot.org/uniprot/A0A2K5TL59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/9541:GNPDA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5J5|||http://purl.uniprot.org/uniprot/A0A2K5V5N2|||http://purl.uniprot.org/uniprot/G7P8I9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9541:DNTTIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA80 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:FER ^@ http://purl.uniprot.org/uniprot/A0A2K5W0H6|||http://purl.uniprot.org/uniprot/A0A2K5W0I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/9541:NANOS3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CX74 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/9541:NEURL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5N2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:XRCC6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAA5|||http://purl.uniprot.org/uniprot/Q4R673 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus http://togogenome.org/gene/9541:MED18 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:CCNL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPJ8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:ETHE1 ^@ http://purl.uniprot.org/uniprot/G7PXS4 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9541:STXBP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXA1|||http://purl.uniprot.org/uniprot/A0A2K5TXC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:EIF3H ^@ http://purl.uniprot.org/uniprot/A0A2K5UCA2|||http://purl.uniprot.org/uniprot/A0A8J8Y043 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9541:MBL2 ^@ http://purl.uniprot.org/uniprot/Q66S50 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).|||Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.|||Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity (By similarity).|||Secreted|||The coiled-coil domain mediates trimerization. http://togogenome.org/gene/9541:DAND5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X611 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9541:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:CCNJ ^@ http://purl.uniprot.org/uniprot/A0A2K5WK04 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:CACNG7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAN9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. http://togogenome.org/gene/9541:CYP2R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ19 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:SGMS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSC0|||http://purl.uniprot.org/uniprot/G7P620 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9541:FAM13C ^@ http://purl.uniprot.org/uniprot/A0A2K5VNU4 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9541:CHRM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/9541:BOLA3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CWH0 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9541:LOC102134053 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWN3 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9541:RPA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/9541:MOGAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V109 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TAAR2 ^@ http://purl.uniprot.org/uniprot/G7P352 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:VEGFA ^@ http://purl.uniprot.org/uniprot/A0A7N9IDA9|||http://purl.uniprot.org/uniprot/Q95NE5 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9541:GABPA ^@ http://purl.uniprot.org/uniprot/A0A8J8XLW7|||http://purl.uniprot.org/uniprot/G7P1M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:ISCA1 ^@ http://purl.uniprot.org/uniprot/Q4R5F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HesB/IscA family.|||Interacts with CRY2, but not with CRY1 (in vitro).|||Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.|||Mitochondrion http://togogenome.org/gene/9541:LOC102131329 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5Z9 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/9541:NBN ^@ http://purl.uniprot.org/uniprot/E5FGN1 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/9541:NFKB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPZ9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:DEFB114 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4F6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:SERPINB8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7F4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:RAB4A ^@ http://purl.uniprot.org/uniprot/A0A2K5WPN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/9541:TTC39A ^@ http://purl.uniprot.org/uniprot/A0A2K5WJ45 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9541:SOHLH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:VGLL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/9541:LOC102139875 ^@ http://purl.uniprot.org/uniprot/P61251 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS26 family.|||Component of the 40S small ribosomal subunit.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9541:CLN8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFP0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:APOE ^@ http://purl.uniprot.org/uniprot/A2V9Z3 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/9541:ASF1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VAE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9541:TP53INP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V686 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/9541:UGT3A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:NCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8W2|||http://purl.uniprot.org/uniprot/A0A8J8YD01|||http://purl.uniprot.org/uniprot/G7PMW0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/9541:DHRS9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPG0|||http://purl.uniprot.org/uniprot/G7PKR5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:CCL11 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:GPCPD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5R1 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:DEFB121 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8S5|||http://purl.uniprot.org/uniprot/G7PGP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:CDCA8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFX2|||http://purl.uniprot.org/uniprot/G7NUA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the borealin family.|||centromere http://togogenome.org/gene/9541:VAMP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IGI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:RNF146 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVL0|||http://purl.uniprot.org/uniprot/A0A8J8YER2|||http://purl.uniprot.org/uniprot/Q2PFU6 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation (By similarity).|||Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.|||E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein (By similarity). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity). Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity). Does not affect PARP1 activation. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity). Promotes cell survival after gamma-irradiation. Facilitates DNA repair (By similarity).|||E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||Nucleus|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||Ubiquitinated; autoubiquitinated. Autoubiquitination is enhanced upon poly(ADP-ribose)-binding (By similarity).|||cytosol http://togogenome.org/gene/9541:RAD9A ^@ http://purl.uniprot.org/uniprot/A0A2K5WVB6 ^@ Similarity ^@ Belongs to the rad9 family. http://togogenome.org/gene/9541:TRIM46 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMA3 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/9541:EIF5B ^@ http://purl.uniprot.org/uniprot/A0A2K5WL63 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. http://togogenome.org/gene/9541:ZNF274 ^@ http://purl.uniprot.org/uniprot/Q4R8H9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Cytoplasm|||Interacts with SETDB1 and TRIM28/KAP1. Interacts with ATRX. Forms a complex with ATRX, SETDB1 and TRIM28.|||Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity).|||nucleolus http://togogenome.org/gene/9541:FGF18 ^@ http://purl.uniprot.org/uniprot/A0A7N9IA32 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:GNL1 ^@ http://purl.uniprot.org/uniprot/Q4R8D2 ^@ Domain|||Function|||Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family.|||In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.|||Possible regulatory or functional link with the histocompatibility cluster. http://togogenome.org/gene/9541:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRJ7|||http://purl.uniprot.org/uniprot/G7P454 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9541:CHPF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQU6|||http://purl.uniprot.org/uniprot/A0A2K5WQY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:DGAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCM0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/9541:ESD ^@ http://purl.uniprot.org/uniprot/A0A2K5V990 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/9541:PFKM ^@ http://purl.uniprot.org/uniprot/A0A7N9CDZ6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homo- and heterotetramers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RNPS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYG9|||http://purl.uniprot.org/uniprot/G7Q091|||http://purl.uniprot.org/uniprot/Q4R5N1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Cytoplasm|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10 (By similarity).|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus|||Nucleus speckle|||Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions (By similarity).|||Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro (By similarity).|||The RRM domain is required for the formation of the ASAP complex. http://togogenome.org/gene/9541:PRPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9541:KEG98_p06 ^@ http://purl.uniprot.org/uniprot/C3W4Z2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/9541:PARN ^@ http://purl.uniprot.org/uniprot/A0A7N9DBD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Cytoplasm http://togogenome.org/gene/9541:PDE1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WGG4|||http://purl.uniprot.org/uniprot/A0A2K5WGQ6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:VEPH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFK4 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/9541:LTC4S ^@ http://purl.uniprot.org/uniprot/A0A7N9D4G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CAV3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9541:ACTA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYP0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:PNPO ^@ http://purl.uniprot.org/uniprot/A0A2K5X2W4 ^@ Function|||Similarity ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). http://togogenome.org/gene/9541:ARL5A ^@ http://purl.uniprot.org/uniprot/A0A2K5W621 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:S100A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBB8|||http://purl.uniprot.org/uniprot/A0A8J8Y4J9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:ZNF711 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5G0|||http://purl.uniprot.org/uniprot/A0A8J8YJG0|||http://purl.uniprot.org/uniprot/G7Q360 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GTF2A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/9541:ETF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/9541:MFSD11 ^@ http://purl.uniprot.org/uniprot/G7PSW8|||http://purl.uniprot.org/uniprot/Q4R495 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Despite its name it is related to the unc-93 family and not to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:FFAR1 ^@ http://purl.uniprot.org/uniprot/Q76JV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. http://togogenome.org/gene/9541:FBXO48 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y3S8|||http://purl.uniprot.org/uniprot/G7PMC8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.|||Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. http://togogenome.org/gene/9541:PAQR5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRD9|||http://purl.uniprot.org/uniprot/G7P902 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:MRPL47 ^@ http://purl.uniprot.org/uniprot/A0A7N9DBX8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9541:PDE6H ^@ http://purl.uniprot.org/uniprot/A0A8J8YH66|||http://purl.uniprot.org/uniprot/G7PJY4 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/9541:MAPRE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9541:MFSD14B ^@ http://purl.uniprot.org/uniprot/A0A2K5VC27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:LOC102131262 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:LYRM2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHI7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9541:TLL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8M4|||http://purl.uniprot.org/uniprot/A0A2K5U8R3 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:XRN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKV6|||http://purl.uniprot.org/uniprot/A0A8J8YIF4 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/9541:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6I4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/9541:KCNS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQH5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:ACAD9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRB8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:CAPN12 ^@ http://purl.uniprot.org/uniprot/Q4R721 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GORASP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X944 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/9541:OGDH ^@ http://purl.uniprot.org/uniprot/A0A2K5VYI5|||http://purl.uniprot.org/uniprot/A0A2K5VYM0 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9541:LIN28A ^@ http://purl.uniprot.org/uniprot/A0A7N9IH37 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9541:GNAO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3X8|||http://purl.uniprot.org/uniprot/A0A2K5V415 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:ANAPC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3D1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/9541:IMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE45|||http://purl.uniprot.org/uniprot/G8F2V1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9541:PTGES3 ^@ http://purl.uniprot.org/uniprot/I7GKX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p23/wos2 family.|||Cytoplasm|||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.|||Forms a complex with HSP70, HSP90 and other chaperones. http://togogenome.org/gene/9541:EPN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRE9|||http://purl.uniprot.org/uniprot/A0A2K5WRF8 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/9541:LOC102125186 ^@ http://purl.uniprot.org/uniprot/Q4R882 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:DKK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMC3|||http://purl.uniprot.org/uniprot/A0A7N9IE82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9541:CHRNA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:MS4A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ04 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:LARP7 ^@ http://purl.uniprot.org/uniprot/Q4R627 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LARP7 family.|||Core component of the 7SK RNP complex, at least composed of 7SK RNA, LARP7, MEPCE, HEXIM1 (or HEXIM2) and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1). Interacts with METTL16. Interacts with RBM7; upon genotoxic stress this interaction is enhanced, triggering the release of inactive P-TEFb complex from the core, yielding to P-TEFb complex activation. Associates with box C/D small nucleolar ribonucleoprotein (snoRNP) complexes.|||RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (By similarity). U6 snRNA processing is required for spermatogenesis (By similarity).|||The xRRM domain binds the 3' end of 7SK snRNA (7SK RNA) at the top of stem-loop 4.|||nucleoplasm http://togogenome.org/gene/9541:MRPL16 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZC6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9541:CCL13 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKY5|||http://purl.uniprot.org/uniprot/G7PU25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:APH1A ^@ http://purl.uniprot.org/uniprot/A0A2K5U529 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/9541:CIBAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CIBAR family.|||centriole|||cilium basal body http://togogenome.org/gene/9541:C2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0I4|||http://purl.uniprot.org/uniprot/G8F3W0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:ABRAXAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM175 family. Abraxas subfamily.|||Nucleus http://togogenome.org/gene/9541:TIMM22 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ESR1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH51|||http://purl.uniprot.org/uniprot/G7P4Y2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer.|||Nucleus|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/9541:SLC25A17 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:LOC102136362 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4L0 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/9541:VPS33B ^@ http://purl.uniprot.org/uniprot/A0A2K5V6T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Early endosome|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/9541:LMNA ^@ http://purl.uniprot.org/uniprot/A0A8J8YBF0|||http://purl.uniprot.org/uniprot/G7NV78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/9541:CD99L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGR7|||http://purl.uniprot.org/uniprot/A0A2K5VGY7 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/9541:ARHGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCY5 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Golgi apparatus|||Vesicle|||spindle|||tight junction http://togogenome.org/gene/9541:CEPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL08|||http://purl.uniprot.org/uniprot/A0A2K5VL10|||http://purl.uniprot.org/uniprot/A0A8J8YNT5 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/9541:ITGB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PRKG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ44|||http://purl.uniprot.org/uniprot/A0A2K5VZ60 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9541:FCGRT ^@ http://purl.uniprot.org/uniprot/Q8SPV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.|||Endosome membrane|||FcRn complex consists of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity). Interacts with albumin/ALB; this interaction regulates ALB homeostasis (By similarity). http://togogenome.org/gene/9541:IL22 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHW8|||http://purl.uniprot.org/uniprot/G7PHZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Secreted http://togogenome.org/gene/9541:TMEM126A ^@ http://purl.uniprot.org/uniprot/A0A8J8YQX2|||http://purl.uniprot.org/uniprot/G7PND4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:FBXO15 ^@ http://purl.uniprot.org/uniprot/Q9GKV7 ^@ Function|||Subunit ^@ Directly interacts with SKP1 and CUL1.|||Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9541:HMOX2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHX2|||http://purl.uniprot.org/uniprot/G7Q0E3 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/9541:KCNJ10 ^@ http://purl.uniprot.org/uniprot/G7NWC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||cilium basal body http://togogenome.org/gene/9541:TRIM69 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0Q5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:RPRD1B ^@ http://purl.uniprot.org/uniprot/A0A8J8YRX8|||http://purl.uniprot.org/uniprot/G7PGE9 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/9541:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1J5|||http://purl.uniprot.org/uniprot/A0A2K5U1K1 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9541:MT1E ^@ http://purl.uniprot.org/uniprot/G7Q165 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9541:IQCD ^@ http://purl.uniprot.org/uniprot/A0A2K5TTU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/9541:DEDD ^@ http://purl.uniprot.org/uniprot/A0A8J8XXP3|||http://purl.uniprot.org/uniprot/G7NXA0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:RNASEH2A ^@ http://purl.uniprot.org/uniprot/A0A7N9IAX6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/9541:TINAG ^@ http://purl.uniprot.org/uniprot/A0A2K5VFX9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9541:ARL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB91|||http://purl.uniprot.org/uniprot/A0A8J8XKV2|||http://purl.uniprot.org/uniprot/G7NZ67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/9541:MS4A13 ^@ http://purl.uniprot.org/uniprot/G7PPZ9 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:GPATCH11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEM5 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/9541:CCR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5W1 ^@ Similarity|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis. http://togogenome.org/gene/9541:ITM2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WKG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/9541:RELL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7N4 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/9541:VPS28 ^@ http://purl.uniprot.org/uniprot/A0A7N9CK83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.|||Membrane http://togogenome.org/gene/9541:SDR42E1 ^@ http://purl.uniprot.org/uniprot/G7PZU6|||http://purl.uniprot.org/uniprot/Q4R7R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-beta-HSD family.|||Membrane http://togogenome.org/gene/9541:LOC102143165 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAT7|||http://purl.uniprot.org/uniprot/G7PQY2 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:TRAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9541:ABRACL ^@ http://purl.uniprot.org/uniprot/A0A2K5WRC0 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/9541:IDE ^@ http://purl.uniprot.org/uniprot/A0A2K5TUD2 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9541:LPL ^@ http://purl.uniprot.org/uniprot/A0A7N9D851|||http://purl.uniprot.org/uniprot/I7GCW6 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/9541:TBPL1 ^@ http://purl.uniprot.org/uniprot/Q4R848 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB.|||Cytoplasm|||Nucleus|||Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity). http://togogenome.org/gene/9541:RAB3C ^@ http://purl.uniprot.org/uniprot/A0A7N9CIY2|||http://purl.uniprot.org/uniprot/A0A8J8XFS3|||http://purl.uniprot.org/uniprot/G7P7K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9541:NUDT4 ^@ http://purl.uniprot.org/uniprot/A0A7N9I9E1 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9541:SEC11A ^@ http://purl.uniprot.org/uniprot/A0A2K5TS20|||http://purl.uniprot.org/uniprot/A0A2K5TS29|||http://purl.uniprot.org/uniprot/A0A2K5TS41 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:COPG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U893|||http://purl.uniprot.org/uniprot/A0A7N9IBS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9541:IRF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Nucleus http://togogenome.org/gene/9541:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A2K5V7B1|||http://purl.uniprot.org/uniprot/A0A8J8Y9P5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:RPL26L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0P7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/9541:GPAM ^@ http://purl.uniprot.org/uniprot/A0A2K5V1Q6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:SLC7A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XU70|||http://purl.uniprot.org/uniprot/G7PVY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DCTN6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.|||cytoskeleton http://togogenome.org/gene/9541:CBR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW11 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9541:DPT ^@ http://purl.uniprot.org/uniprot/A0A2K5VRK7 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/9541:RARS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGN1|||http://purl.uniprot.org/uniprot/G7P6U6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:NOTCH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7P6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/9541:SFMBT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W642 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MLST8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.|||Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA. http://togogenome.org/gene/9541:CNIH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9541:ATP2A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URR3|||http://purl.uniprot.org/uniprot/A0A2K5URW4|||http://purl.uniprot.org/uniprot/A0A7N9D608 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/9541:SLC13A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9541:SH3BP5L ^@ http://purl.uniprot.org/uniprot/A0A2K5WLD2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/9541:HMGN4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CUD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:LOC102145605 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:CENPK ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6U8|||http://purl.uniprot.org/uniprot/G7P7M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/9541:GLA ^@ http://purl.uniprot.org/uniprot/A0A2K5V2Q7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9541:PTCD2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CFC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTCD2 family.|||Mitochondrion http://togogenome.org/gene/9541:TMBIM6 ^@ http://purl.uniprot.org/uniprot/I7GKH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/9541:PDCD10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRK1|||http://purl.uniprot.org/uniprot/A0A979HKW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:IL6 ^@ http://purl.uniprot.org/uniprot/G7P0R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9541:PAX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK65|||http://purl.uniprot.org/uniprot/I7G9J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9541:PSMB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGD3|||http://purl.uniprot.org/uniprot/G7P4A9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TMEM161B ^@ http://purl.uniprot.org/uniprot/A0A2K5VDR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/9541:LOC102146235 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/9541:TSPAN31 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP83|||http://purl.uniprot.org/uniprot/A0A8J8Y0F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:HYAL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGW3|||http://purl.uniprot.org/uniprot/A0A2K5VH22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Early endosome|||Endoplasmic reticulum|||Endosome|||Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage.|||Membrane|||acrosome http://togogenome.org/gene/9541:SEC24C ^@ http://purl.uniprot.org/uniprot/A0A2K5U7M0|||http://purl.uniprot.org/uniprot/A0A7N9D9T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:BST1 ^@ http://purl.uniprot.org/uniprot/E5G6H5 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/9541:KIF9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ68|||http://purl.uniprot.org/uniprot/A0A8J8YN76|||http://purl.uniprot.org/uniprot/G7NXW4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:DDIT4L ^@ http://purl.uniprot.org/uniprot/A0A8J8XRQ5|||http://purl.uniprot.org/uniprot/G7P5Z9 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9541:ATG101 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC85|||http://purl.uniprot.org/uniprot/G7PIC2 ^@ Similarity ^@ Belongs to the ATG101 family. http://togogenome.org/gene/9541:KCNJ6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5N4|||http://purl.uniprot.org/uniprot/A0A8J8XP04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/9541:LOC102133077 ^@ http://purl.uniprot.org/uniprot/G8F3F9 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:GABBR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNP9|||http://purl.uniprot.org/uniprot/A0A7N9DEY1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ZDHHC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3H3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:LSM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9H6|||http://purl.uniprot.org/uniprot/G8F3W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/9541:MBTD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRD0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CX3CR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJQ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.|||Membrane http://togogenome.org/gene/9541:EPHA7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWR7|||http://purl.uniprot.org/uniprot/G7P422 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ZHX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9541:UBE2D3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W840|||http://purl.uniprot.org/uniprot/Q4R5N4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production. Together with ZNF598, catalyzes ubiquitination of 40S ribosomal proteins in response to ribosome collisions. In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2.|||Belongs to the ubiquitin-conjugating enzyme family.|||Cell membrane|||Endosome membrane|||Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC. Interacts with UBTD1 (By similarity). Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation (By similarity).|||Phosphorylated by AURKB. http://togogenome.org/gene/9541:FXYD4 ^@ http://purl.uniprot.org/uniprot/A0A7N9DEE3|||http://purl.uniprot.org/uniprot/A0A8J8YJX1|||http://purl.uniprot.org/uniprot/G7PER3 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9541:TNPO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCI7|||http://purl.uniprot.org/uniprot/A0A2K5WCL6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:RNF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7H0 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9541:STAC ^@ http://purl.uniprot.org/uniprot/A0A7N9CCB6 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9541:SCGB1A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH17|||http://purl.uniprot.org/uniprot/G7PPU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the secretoglobin family.|||Secreted http://togogenome.org/gene/9541:ART3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMJ0 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9541:PON3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNZ3 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9541:ETV4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W122 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:ESRRA ^@ http://purl.uniprot.org/uniprot/A0A2K5VB75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9541:SMG8 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4H0|||http://purl.uniprot.org/uniprot/G7PUG9 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. http://togogenome.org/gene/9541:KEG98_p12 ^@ http://purl.uniprot.org/uniprot/C3W4Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DCTN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W558|||http://purl.uniprot.org/uniprot/A0A8J8YS99|||http://purl.uniprot.org/uniprot/G7P8Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunit 4 family.|||cell cortex|||centrosome|||sarcomere|||stress fiber http://togogenome.org/gene/9541:RFC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKM6|||http://purl.uniprot.org/uniprot/G8F2Q2 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9541:HCAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULI6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:LOC102146577 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:NDUFA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:F10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHK1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:LOC102136791 ^@ http://purl.uniprot.org/uniprot/A0A2K5V173|||http://purl.uniprot.org/uniprot/A0A2K5V183|||http://purl.uniprot.org/uniprot/A0A2K5V186 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9541:FGF20 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCR8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:ZC3H12A ^@ http://purl.uniprot.org/uniprot/A0A2K5V3E9 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/9541:LBX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFD2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PEX13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCM6 ^@ Similarity ^@ Belongs to the peroxin-13 family. http://togogenome.org/gene/9541:RPSA ^@ http://purl.uniprot.org/uniprot/I7G7S3 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/9541:EIF2A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y686|||http://purl.uniprot.org/uniprot/G7NZM4 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/9541:LOC102122931 ^@ http://purl.uniprot.org/uniprot/A0A7N9D2E9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HDAC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0C9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9541:LOC102144583 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCN9|||http://purl.uniprot.org/uniprot/G7NTR6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SS18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBW7 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9541:DLST ^@ http://purl.uniprot.org/uniprot/A0A2K5UP28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:CORO2A ^@ http://purl.uniprot.org/uniprot/A0A2K5UKF1 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9541:CPSF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIL5|||http://purl.uniprot.org/uniprot/G7PBB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/9541:TSG101 ^@ http://purl.uniprot.org/uniprot/A0A8J8YL06|||http://purl.uniprot.org/uniprot/G7PQL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.|||Membrane http://togogenome.org/gene/9541:PGM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRN8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9541:PEX3 ^@ http://purl.uniprot.org/uniprot/G7P307|||http://purl.uniprot.org/uniprot/Q60HE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-3 family.|||Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (By similarity).|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/9541:MGAT4D ^@ http://purl.uniprot.org/uniprot/A0A2K5W3K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:TPD52L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0K9|||http://purl.uniprot.org/uniprot/A0A2K5X0T1|||http://purl.uniprot.org/uniprot/A0A2K5X0W8|||http://purl.uniprot.org/uniprot/A0A2K5X164|||http://purl.uniprot.org/uniprot/A0A8J8XXK1 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/9541:CEP170 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0P2 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/9541:LOC107129595 ^@ http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:LOC102116377 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:NUDT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U315 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9541:DEGS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102131576 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9541:DCP1A ^@ http://purl.uniprot.org/uniprot/A0A2K5WI42 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/9541:SGMS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/9541:LOC102118097 ^@ http://purl.uniprot.org/uniprot/A0A8U0WQ25|||http://purl.uniprot.org/uniprot/G8F3V0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:ANAPC16 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/9541:PABPC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWH5|||http://purl.uniprot.org/uniprot/A0A2K5WWI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/9541:TMSB15B ^@ http://purl.uniprot.org/uniprot/A0A8J8XD17|||http://purl.uniprot.org/uniprot/G7Q3A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9541:SSTR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEB0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:AMT ^@ http://purl.uniprot.org/uniprot/A0A2K5WBL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9541:PIGS ^@ http://purl.uniprot.org/uniprot/A0A8J8YJ93|||http://purl.uniprot.org/uniprot/G7PTX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PRKACA ^@ http://purl.uniprot.org/uniprot/A0A2K5UC31 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9541:OGDHL ^@ http://purl.uniprot.org/uniprot/A0A2K5UXT3 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/9541:GLRA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH11|||http://purl.uniprot.org/uniprot/A0A2K5WH44|||http://purl.uniprot.org/uniprot/A0A8J8Y2D0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9541:DUXA ^@ http://purl.uniprot.org/uniprot/A0A2K5VE58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TNS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/9541:PCK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9M9 ^@ Similarity|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Monomer. http://togogenome.org/gene/9541:CLIC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP59 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/9541:MC1R ^@ http://purl.uniprot.org/uniprot/A3KF54|||http://purl.uniprot.org/uniprot/A3KF60 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with OPN3; the interaction results in a decrease in MC1R-mediated cAMP signaling and ultimately a decrease in melanin production in melanocytes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. http://togogenome.org/gene/9541:WASHC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU23 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/9541:EFNB3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSQ9 ^@ Caution|||Similarity ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:OTULIN ^@ http://purl.uniprot.org/uniprot/A0A2K5WJB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/9541:LOC102124421 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7N0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. TRA1 subfamily. http://togogenome.org/gene/9541:TUBA1C ^@ http://purl.uniprot.org/uniprot/A0A805QYG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1Z4|||http://purl.uniprot.org/uniprot/A0A2K5W200|||http://purl.uniprot.org/uniprot/A0A2K5W202|||http://purl.uniprot.org/uniprot/A0A2K5W211 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/9541:DDX43 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDJ5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:TSHB ^@ http://purl.uniprot.org/uniprot/A0A2K5X6T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9541:RPL10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDM4|||http://purl.uniprot.org/uniprot/G7Q3B3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9541:IMPG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0I2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||interphotoreceptor matrix http://togogenome.org/gene/9541:SLC25A26 ^@ http://purl.uniprot.org/uniprot/I7GN77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:C7 ^@ http://purl.uniprot.org/uniprot/A0A7N9IA03 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:PCBD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U618 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/9541:NR1D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:NXF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/9541:RAB39A ^@ http://purl.uniprot.org/uniprot/A0A2K5VG96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:STK32A ^@ http://purl.uniprot.org/uniprot/A0A2K5UD14 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:HSPA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cell surface|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9541:RDH11 ^@ http://purl.uniprot.org/uniprot/G8F2I0|||http://purl.uniprot.org/uniprot/Q4JK72 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:SCMH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3S2|||http://purl.uniprot.org/uniprot/A0A2K5W3U6|||http://purl.uniprot.org/uniprot/A0A2K5W3U7|||http://purl.uniprot.org/uniprot/A0A8J8YP52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9541:LOC102144275 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3P5 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/9541:PAGE2B ^@ http://purl.uniprot.org/uniprot/A0A2K5W4M5 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:LOC102120633 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1W8|||http://purl.uniprot.org/uniprot/A0A7N9CB00 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9541:RSPO2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y480|||http://purl.uniprot.org/uniprot/G7PCH9 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9541:PAQR8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:RPL22L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVQ1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/9541:SFXN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2P2|||http://purl.uniprot.org/uniprot/A0A8J8XHZ4|||http://purl.uniprot.org/uniprot/G7P6Y2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:SDHAF4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBD7|||http://purl.uniprot.org/uniprot/G7P2Z8 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/9541:IGF2BP3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CA49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9541:RANGRF ^@ http://purl.uniprot.org/uniprot/A0A2K5VH47|||http://purl.uniprot.org/uniprot/A0A2K5VHA4 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/9541:WARS2 ^@ http://purl.uniprot.org/uniprot/G7NX63 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:TMEM106A ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ61|||http://purl.uniprot.org/uniprot/A0A8J8Y5F0|||http://purl.uniprot.org/uniprot/G7PUX6 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9541:DYNLT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPL7 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/9541:APLP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNL8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LOC102115969 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAJ5|||http://purl.uniprot.org/uniprot/G7NXM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:MARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UET5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:IP6K2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWS7 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9541:LOC102120369 ^@ http://purl.uniprot.org/uniprot/A0A2K5V493 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102136862 ^@ http://purl.uniprot.org/uniprot/A4L264|||http://purl.uniprot.org/uniprot/S6E293 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9541:MPDU1 ^@ http://purl.uniprot.org/uniprot/G7PTI3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CDH4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYM4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GPR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:VAMP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:HSPA13 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTB4|||http://purl.uniprot.org/uniprot/G7P242 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/9541:ATG16L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQA7 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/9541:CLDN2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF99|||http://purl.uniprot.org/uniprot/G7Q3E1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:TXNL4A ^@ http://purl.uniprot.org/uniprot/A0A2K5U5Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9541:SNX32 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB75 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9541:ESCO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W278|||http://purl.uniprot.org/uniprot/A0A7N9CRD6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC123566751 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9541:G2E3 ^@ http://purl.uniprot.org/uniprot/Q4R9C4 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.|||Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity.|||nucleolus http://togogenome.org/gene/9541:DEFB118 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:FAM166C ^@ http://purl.uniprot.org/uniprot/A0A2K5TMN1 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9541:PROX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MSRB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWU1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit.|||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. http://togogenome.org/gene/9541:STX11 ^@ http://purl.uniprot.org/uniprot/A0A8J8YD53|||http://purl.uniprot.org/uniprot/G7P509 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:OSBPL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF67|||http://purl.uniprot.org/uniprot/A0A2K5WF76|||http://purl.uniprot.org/uniprot/A0A2K5WFF0|||http://purl.uniprot.org/uniprot/A0A8J8YEW8|||http://purl.uniprot.org/uniprot/G7PKX7 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:LOC101867486 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLZ9|||http://purl.uniprot.org/uniprot/G7P4F8 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/9541:ERBB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0D3|||http://purl.uniprot.org/uniprot/A0A2K5W0D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9541:CXCL11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWC3|||http://purl.uniprot.org/uniprot/G7P556 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:PCMTD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCP9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/9541:COPA ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ52|||http://purl.uniprot.org/uniprot/G7NWD0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/9541:MST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCZ4 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SEM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZN6|||http://purl.uniprot.org/uniprot/G7P1B4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/9541:NDRG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQV9|||http://purl.uniprot.org/uniprot/A0A2K5VQZ6 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/9541:SLC7A9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMC4|||http://purl.uniprot.org/uniprot/G7PX58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:INPP4B ^@ http://purl.uniprot.org/uniprot/A0A2K5UC87|||http://purl.uniprot.org/uniprot/A0A2K5UC97 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/9541:KRT36 ^@ http://purl.uniprot.org/uniprot/A0A2K5WK83 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:HJV ^@ http://purl.uniprot.org/uniprot/A0A2K5TJX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PGAP3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CNG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Membrane http://togogenome.org/gene/9541:VAMP7 ^@ http://purl.uniprot.org/uniprot/A0A7N9D129 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:MTCP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7K1 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9541:MEOX2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4L1|||http://purl.uniprot.org/uniprot/G7P192 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102137032 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ02 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9541:DEFB113 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:CDH10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCU9|||http://purl.uniprot.org/uniprot/G7P7A7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RBP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W172 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Interacts with TTR.|||Retinol-binding protein that mediates retinol transport in blood plasma.|||Secreted http://togogenome.org/gene/9541:DCT ^@ http://purl.uniprot.org/uniprot/A0A2K5VPR3|||http://purl.uniprot.org/uniprot/A0A8J8XD96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/9541:RO60 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFB4|||http://purl.uniprot.org/uniprot/G7NXD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/9541:OSBPL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP32 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:APOC1 ^@ http://purl.uniprot.org/uniprot/P18657 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.|||Belongs to the apolipoprotein C1 family.|||Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.|||Secreted http://togogenome.org/gene/9541:TIPIN ^@ http://purl.uniprot.org/uniprot/A0A2K5UYX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/9541:B3GNT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:CCM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWM1|||http://purl.uniprot.org/uniprot/A0A2K5TWQ3 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/9541:CAPN1 ^@ http://purl.uniprot.org/uniprot/Q9GLG2 ^@ Activity Regulation|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Activated by micromolar concentrations of calcium and inhibited by calpastatin.|||Belongs to the peptidase C2 family.|||Binds 4 Ca(2+) ions.|||Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Cleaves and activates caspase-7 (CASP7).|||Cell membrane|||Cytoplasm|||Forms a heterodimer with a small (regulatory) subunit (CAPNS1).|||Ubiquitous.|||Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity). http://togogenome.org/gene/9541:PPARG ^@ http://purl.uniprot.org/uniprot/A0A2K5WFM9|||http://purl.uniprot.org/uniprot/A0A2K5WFQ0|||http://purl.uniprot.org/uniprot/A0A8J8YEQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/9541:SLC66A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPR6|||http://purl.uniprot.org/uniprot/A0A2K5WPV1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:FPR1 ^@ http://purl.uniprot.org/uniprot/G7PYI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RAD51 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/9541:MFSD10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DOCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQR8 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:TMEM168 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIL0|||http://purl.uniprot.org/uniprot/A0A8J8XBZ6|||http://purl.uniprot.org/uniprot/G7P2H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9541:USP15 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK24|||http://purl.uniprot.org/uniprot/A0A2K5TK29|||http://purl.uniprot.org/uniprot/A0A8J8YA73|||http://purl.uniprot.org/uniprot/G7PIX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/9541:ACTR8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YT00|||http://purl.uniprot.org/uniprot/G7NZU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/9541:XPO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNY6|||http://purl.uniprot.org/uniprot/A0A7N9CMG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/9541:GCHFR ^@ http://purl.uniprot.org/uniprot/A0A8J8YET9|||http://purl.uniprot.org/uniprot/G7PAX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GFRP family.|||Membrane|||Nucleus membrane|||cytosol http://togogenome.org/gene/9541:LOC102120481 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9N2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PIP family.|||Monomer. Interacts with AZGP1.|||Secreted http://togogenome.org/gene/9541:SLC30A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:LRRC51 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTJ8|||http://purl.uniprot.org/uniprot/A0A8J8XIN6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:HSPH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIW1|||http://purl.uniprot.org/uniprot/A0A7N9CYX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm http://togogenome.org/gene/9541:PSMF1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CTK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/9541:CLDN14 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGB7|||http://purl.uniprot.org/uniprot/G7P110 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:C2H3orf70 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6P6 ^@ Similarity ^@ Belongs to the UPF0524 family. http://togogenome.org/gene/9541:PMM2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5M6|||http://purl.uniprot.org/uniprot/Q60HD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/9541:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPW4 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/9541:SMG6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9N0 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.|||Plays a role in nonsense-mediated mRNA decay.|||The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.|||cytosol|||nucleolus|||telomere http://togogenome.org/gene/9541:LOC102117721 ^@ http://purl.uniprot.org/uniprot/G7P2L6|||http://purl.uniprot.org/uniprot/G7P2P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CCL23 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:NKX6-3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X268 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RPS23 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS12 family.|||Rough endoplasmic reticulum http://togogenome.org/gene/9541:HNRNPF ^@ http://purl.uniprot.org/uniprot/A0A8J8YQZ5|||http://purl.uniprot.org/uniprot/G7PER4|||http://purl.uniprot.org/uniprot/Q60HC3 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).|||Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1 (By similarity).|||Sumoylated.|||The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.|||nucleoplasm http://togogenome.org/gene/9541:LOC102124658 ^@ http://purl.uniprot.org/uniprot/I7GPH0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/9541:CASTOR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZC7 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/9541:PHKA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLC1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/9541:PDIK1L ^@ http://purl.uniprot.org/uniprot/A0A2K5VL47|||http://purl.uniprot.org/uniprot/A0A7N9CFE3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:TBX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U947 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:ARHGDIB ^@ http://purl.uniprot.org/uniprot/A0A2K5X5E9 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/9541:LOC102129682 ^@ http://purl.uniprot.org/uniprot/Q4R4K6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS6 family.|||Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.|||Component of the small ribosomal subunit.|||Cytoplasm|||Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.|||Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.|||Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8. http://togogenome.org/gene/9541:CHEK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAE9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/9541:ARSL ^@ http://purl.uniprot.org/uniprot/A0A2K5WPD0|||http://purl.uniprot.org/uniprot/A0A2K5WPF2 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9541:PDYN ^@ http://purl.uniprot.org/uniprot/A0A7N9I981 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opioid activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/9541:GPC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9541:SNX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/9541:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVU3 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9541:TNFRSF9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDS9|||http://purl.uniprot.org/uniprot/A9YYE7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PLP1 ^@ http://purl.uniprot.org/uniprot/I7G2D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9541:CLDN19 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHK0|||http://purl.uniprot.org/uniprot/A0A7N9C8X1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIZ2 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/9541:ITPA ^@ http://purl.uniprot.org/uniprot/A0A2K5X2C2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/9541:NPRL2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVQ8|||http://purl.uniprot.org/uniprot/G7NXS3 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/9541:KEG98_p09 ^@ http://purl.uniprot.org/uniprot/C3W4Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/9541:KIF17 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJL7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:BMT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9541:GPC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan. http://togogenome.org/gene/9541:TIGD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULI2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:KPNA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9F2 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:MARVELD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9541:LOC102133777 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNB8|||http://purl.uniprot.org/uniprot/G7PII2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:LOC102123177 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FXYD family.|||May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.|||Membrane|||Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. http://togogenome.org/gene/9541:DRD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:THUMPD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ92 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/9541:TAF5L ^@ http://purl.uniprot.org/uniprot/A0A2K5U671 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/9541:KRR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/9541:SLC6A13 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN47|||http://purl.uniprot.org/uniprot/Q2PG55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Lateral cell membrane|||Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (By similarity). Can also mediate transport of beta-alanine, taurine and hypotaurine (By similarity).|||Membrane http://togogenome.org/gene/9541:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8J0|||http://purl.uniprot.org/uniprot/A0A8J8XTV6|||http://purl.uniprot.org/uniprot/G7PEE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/9541:IFT46 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPG7|||http://purl.uniprot.org/uniprot/G8F447 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/9541:CPLX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X485 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9541:CDC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLB1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/9541:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5X3|||http://purl.uniprot.org/uniprot/G7NZP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9541:RPS20 ^@ http://purl.uniprot.org/uniprot/G7Q2E4|||http://purl.uniprot.org/uniprot/Q4R5D0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Polyubiquitinated by ZNF598 via 'Lys-63'-linked ubiquitin chains when a ribosome has stalled, initiating the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide. Deubiquitinated by OTUD3 and USP21, antagonizing ZNF598 activity.|||Ufmylated by UFL1. http://togogenome.org/gene/9541:PLCG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W153 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/9541:LOC102140245 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1M2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9541:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9541:KCNA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKT9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:SH3RF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZW3 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/9541:ATP13A3 ^@ http://purl.uniprot.org/uniprot/Q95JN5 ^@ Function|||Sequence Caution|||Similarity|||Subcellular Location Annotation ^@ ATP-driven pump involved in endocytosis-dependent polyamine transport. Uses ATP as an energy source to transfer polyamine precursor putrescine from the endosomal compartment to the cytosol.|||Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Contaminating sequence. Potential poly-A sequence.|||Early endosome membrane|||Late endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9541:TLN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGA4|||http://purl.uniprot.org/uniprot/A0A8J8XB34|||http://purl.uniprot.org/uniprot/G7PRZ9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:TMEM39B ^@ http://purl.uniprot.org/uniprot/A0A2K5TPN6|||http://purl.uniprot.org/uniprot/A0A2K5TPQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/9541:LSM6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V611|||http://purl.uniprot.org/uniprot/G8F3L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/9541:MRPS16 ^@ http://purl.uniprot.org/uniprot/G7PF15 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/9541:BABAM2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CLQ8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/9541:IL1RN ^@ http://purl.uniprot.org/uniprot/A0A7N9DF26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9541:UBE4B ^@ http://purl.uniprot.org/uniprot/A0A2K5W1H3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm|||The U-box domain is required for the ubiquitin protein ligase activity.|||Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. http://togogenome.org/gene/9541:C12H2orf88 ^@ http://purl.uniprot.org/uniprot/A0A7N9CPM8|||http://purl.uniprot.org/uniprot/A0A8J8XQP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small membrane AKAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SYBU ^@ http://purl.uniprot.org/uniprot/A0A2K5WIU6|||http://purl.uniprot.org/uniprot/A0A2K5WIV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ACVR2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WUB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:MMP19 ^@ http://purl.uniprot.org/uniprot/A0A2K5U112 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9541:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A2K5UL93 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:GNRHR ^@ http://purl.uniprot.org/uniprot/A0A2K5WH82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102134028 ^@ http://purl.uniprot.org/uniprot/A0A7N9CRH6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. http://togogenome.org/gene/9541:MTX2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y183|||http://purl.uniprot.org/uniprot/G7PKW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:ATF7IP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ39|||http://purl.uniprot.org/uniprot/A0A2K5UZ50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/9541:HSA3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZM3|||http://purl.uniprot.org/uniprot/G7PIE1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Odorant receptor. http://togogenome.org/gene/9541:E2F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:STMN1 ^@ http://purl.uniprot.org/uniprot/A0A805RLD7|||http://purl.uniprot.org/uniprot/Q25QD1|||http://purl.uniprot.org/uniprot/Q4R712 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the stathmin family.|||Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST (By similarity).|||Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).|||Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity (By similarity).|||cytoskeleton http://togogenome.org/gene/9541:SH2D1A ^@ http://purl.uniprot.org/uniprot/A0A2K5U0G4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. http://togogenome.org/gene/9541:GADD45B ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6A9|||http://purl.uniprot.org/uniprot/G7PYD1 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9541:NLN ^@ http://purl.uniprot.org/uniprot/A0A2K5UXD0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/9541:GPR6 ^@ http://purl.uniprot.org/uniprot/G8F545 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:FLAD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYE5|||http://purl.uniprot.org/uniprot/G7NUJ8 ^@ Function|||Similarity ^@ Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.|||In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9541:LOC102128952 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Membrane http://togogenome.org/gene/9541:MINDY3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXL7|||http://purl.uniprot.org/uniprot/G7PEF7|||http://purl.uniprot.org/uniprot/Q4R528 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.|||Interacts with COPS5.|||Nucleus http://togogenome.org/gene/9541:AP1S2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTY7|||http://purl.uniprot.org/uniprot/A0A2K5TU05|||http://purl.uniprot.org/uniprot/A0A7N9DB11|||http://purl.uniprot.org/uniprot/A0A8J8XS11|||http://purl.uniprot.org/uniprot/G7Q2A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9541:ZFX ^@ http://purl.uniprot.org/uniprot/A0A2K5UW34|||http://purl.uniprot.org/uniprot/A0A2K5UW70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:THBS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V619 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:POMGNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKS6|||http://purl.uniprot.org/uniprot/A0A7N9CN01|||http://purl.uniprot.org/uniprot/G7NV04 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The cofactor is mostly bound to the substrate.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/9541:FGB ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ55|||http://purl.uniprot.org/uniprot/G7P6F7 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/9541:TMEM256 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPW7|||http://purl.uniprot.org/uniprot/G7PTH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM256 family.|||Membrane http://togogenome.org/gene/9541:GPR155 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HDX ^@ http://purl.uniprot.org/uniprot/A0A2K5W8Y0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102138546 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQA3|||http://purl.uniprot.org/uniprot/G7NTQ1 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:CDKAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9T0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:SLC24A5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5C6|||http://purl.uniprot.org/uniprot/G7PV94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9541:CACNA2D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRT5|||http://purl.uniprot.org/uniprot/A0A2K5VRW1|||http://purl.uniprot.org/uniprot/A0A7N9ICS8 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9541:NDST2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9541:VAMP4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDD2|||http://purl.uniprot.org/uniprot/G7NVH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:DGKE ^@ http://purl.uniprot.org/uniprot/A0A7N9CLX3 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/9541:LOC102129860 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUY6 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9541:NIPSNAP3A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y936|||http://purl.uniprot.org/uniprot/G7PRS1 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/9541:CTNNA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE01|||http://purl.uniprot.org/uniprot/A0A8J8XE84|||http://purl.uniprot.org/uniprot/G7PML1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction http://togogenome.org/gene/9541:FOXA3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CHB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TREX1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D4U6 ^@ Similarity ^@ Belongs to the exonuclease superfamily. TREX family. http://togogenome.org/gene/9541:ANKH ^@ http://purl.uniprot.org/uniprot/A0A2K5WPU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/9541:BLCAP ^@ http://purl.uniprot.org/uniprot/A0A7N9CIA7|||http://purl.uniprot.org/uniprot/A0A8J8Y731 ^@ Function|||Similarity ^@ Belongs to the BLCAP family.|||May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. http://togogenome.org/gene/9541:TMEM165 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/9541:GNGT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:ENO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9541:CD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YDH1|||http://purl.uniprot.org/uniprot/G7PJN3 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs. http://togogenome.org/gene/9541:CCS ^@ http://purl.uniprot.org/uniprot/A0A2K5X1C8 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/9541:GNG3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIX8|||http://purl.uniprot.org/uniprot/I7GMQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKF4|||http://purl.uniprot.org/uniprot/A0A2K5TKK1|||http://purl.uniprot.org/uniprot/A0A2K5TKK3|||http://purl.uniprot.org/uniprot/A0A8J8XM37 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:PEMT ^@ http://purl.uniprot.org/uniprot/A0A2K5WQG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:S100A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB64 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:LITAF ^@ http://purl.uniprot.org/uniprot/A0A7N9IFP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane http://togogenome.org/gene/9541:RLN2 ^@ http://purl.uniprot.org/uniprot/G7PSF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.|||Secreted http://togogenome.org/gene/9541:MEA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7N4|||http://purl.uniprot.org/uniprot/G7P3Y9 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/9541:TM9SF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9541:C9H10orf53 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMA8 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/9541:PIERCE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEM4 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9541:TMEM186 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM186 family.|||Membrane http://togogenome.org/gene/9541:GPR50 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PAPOLA ^@ http://purl.uniprot.org/uniprot/A0A2K5TXG9|||http://purl.uniprot.org/uniprot/A0A2K5TXH2|||http://purl.uniprot.org/uniprot/A0A2K5TXL7|||http://purl.uniprot.org/uniprot/A0A2K5TXP6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/9541:TRIM17 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV96|||http://purl.uniprot.org/uniprot/A0A7N9D4A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:MMP16 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC73|||http://purl.uniprot.org/uniprot/G7PC63 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9541:POFUT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 65 family.|||Endoplasmic reticulum http://togogenome.org/gene/9541:DZIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UR24|||http://purl.uniprot.org/uniprot/A0A2K5UR64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||cilium basal body http://togogenome.org/gene/9541:MGAT5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XC29|||http://purl.uniprot.org/uniprot/G7PN39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/9541:GPD1L ^@ http://purl.uniprot.org/uniprot/A0A2K5V4P5|||http://purl.uniprot.org/uniprot/A0A8J8XJW7 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9541:ARHGEF9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8X3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|||Cytoplasm|||Interacts with GPHN.|||Postsynaptic density http://togogenome.org/gene/9541:LOC102144671 ^@ http://purl.uniprot.org/uniprot/G7PKU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS2 family.|||Cytoplasm http://togogenome.org/gene/9541:SLC2A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5URC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Endomembrane system|||Membrane|||perinuclear region http://togogenome.org/gene/9541:LOC102117210 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3K9|||http://purl.uniprot.org/uniprot/A0A2K5U3L6|||http://purl.uniprot.org/uniprot/A0A2K5U3S4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102138406 ^@ http://purl.uniprot.org/uniprot/G7P2Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TRMT2B ^@ http://purl.uniprot.org/uniprot/A0A2K5VUK1|||http://purl.uniprot.org/uniprot/A0A2K5VUK7 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102135688 ^@ http://purl.uniprot.org/uniprot/A0A2K5UM27 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/9541:PRKD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5R6|||http://purl.uniprot.org/uniprot/A0A8J8Y978 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:CCNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0G8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:LOC102127229 ^@ http://purl.uniprot.org/uniprot/P67992|||http://purl.uniprot.org/uniprot/Q25CR9 ^@ Disease Annotation|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prion family.|||Cell membrane|||Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization.|||Golgi apparatus|||Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).|||Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.|||Membrane|||Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization. Interacts with GRB2, APP, ERI3/PRNPIP and SYN1. Mislocalized cytosolically exposed PrP interacts with MGRN1; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement. Interacts with KIAA1191.|||PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.|||The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization. http://togogenome.org/gene/9541:ITGB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SCAMP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9541:LOC102126703 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9541:ST7L ^@ http://purl.uniprot.org/uniprot/A0A2K5U4M1|||http://purl.uniprot.org/uniprot/A0A7N9IG89|||http://purl.uniprot.org/uniprot/G7NW64|||http://purl.uniprot.org/uniprot/Q4R346 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9541:PSMB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRQ2|||http://purl.uniprot.org/uniprot/G7PUK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RBPMS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT66 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:NDUFS3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XXC2|||http://purl.uniprot.org/uniprot/G7PQ90 ^@ Similarity ^@ Belongs to the complex I 30 kDa subunit family. http://togogenome.org/gene/9541:PBX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9541:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDE4|||http://purl.uniprot.org/uniprot/G8F668 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:VAMP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:MARCHF4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS02|||http://purl.uniprot.org/uniprot/G7PLD9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:BMP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUA8 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:TMEM115 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPV1|||http://purl.uniprot.org/uniprot/G7NZZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PSMC2 ^@ http://purl.uniprot.org/uniprot/Q4R4R0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AAA ATPase family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components. Interacts with NDC80/HEC; this interaction is detected only during M phase. Interacts and SQSTM1. Interacts with PAAF1. Directly interacts with TRIM5.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.|||Cytoplasm|||Monoubiquitinated by RNF181.|||Nucleus|||Phosphorylated. Dephosphorylated by UBLCP1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. http://togogenome.org/gene/9541:SLC25A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4N3|||http://purl.uniprot.org/uniprot/A0A2K5W4N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A2K5VK60|||http://purl.uniprot.org/uniprot/A0A2K5VKF1|||http://purl.uniprot.org/uniprot/A0A2K5VKF2|||http://purl.uniprot.org/uniprot/A0A2K5VKH9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9541:SLC6A17 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9541:VIPAS39 ^@ http://purl.uniprot.org/uniprot/G7PB33 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Early endosome|||Endosome|||Late endosome|||Vesicle http://togogenome.org/gene/9541:OTUD7B ^@ http://purl.uniprot.org/uniprot/A0A2K5TTA1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:UBE2D4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D203|||http://purl.uniprot.org/uniprot/A0A7N9D2F9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYY3|||http://purl.uniprot.org/uniprot/G7NVN7 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/9541:LOC102122033 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9H0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/9541:KCNC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4K9|||http://purl.uniprot.org/uniprot/A0A2K5V4M9|||http://purl.uniprot.org/uniprot/A0A2K5V4V6|||http://purl.uniprot.org/uniprot/A0A2K5V4W3|||http://purl.uniprot.org/uniprot/A0A7N9CRZ4|||http://purl.uniprot.org/uniprot/A0A7N9IBK4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:PDCD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM63 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/9541:ACE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X283 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/9541:CAPN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/9541:MFSD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0Q1|||http://purl.uniprot.org/uniprot/G7PHU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Cell membrane|||Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.|||Membrane http://togogenome.org/gene/9541:SMIM14 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAY3|||http://purl.uniprot.org/uniprot/G7P5F8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9541:SLC35F4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9541:PHF20L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4N7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ALDH3A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDK6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:SMPD2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLY1|||http://purl.uniprot.org/uniprot/G7P3P3 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/9541:KCND3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXA6|||http://purl.uniprot.org/uniprot/A0A8J8XCK3|||http://purl.uniprot.org/uniprot/G7NW61 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9541:KEG98_p07 ^@ http://purl.uniprot.org/uniprot/C3W4Z1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/9541:EFHB ^@ http://purl.uniprot.org/uniprot/A0A2K5UL59 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/9541:INHBA ^@ http://purl.uniprot.org/uniprot/A0A2K5WK99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/9541:KDM5C ^@ http://purl.uniprot.org/uniprot/A0A2K5X0F4 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/9541:S100A10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQE4|||http://purl.uniprot.org/uniprot/G7NTU2 ^@ Function ^@ Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. http://togogenome.org/gene/9541:HCRTR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GMFB ^@ http://purl.uniprot.org/uniprot/A0A2K5W225 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9541:IL17RB ^@ http://purl.uniprot.org/uniprot/A0A2K5TUM4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102117012 ^@ http://purl.uniprot.org/uniprot/A0A7N9D238 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W828|||http://purl.uniprot.org/uniprot/A0A2K5W834|||http://purl.uniprot.org/uniprot/A0A8J8XCI2|||http://purl.uniprot.org/uniprot/G7P6X8 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/9541:KRT18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDB4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC102144039 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSB1|||http://purl.uniprot.org/uniprot/A4L283 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9541:GATA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:THAP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/9541:GRK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTN2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9541:LOC102116103 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4B5 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:SRPRB ^@ http://purl.uniprot.org/uniprot/I7GK96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:UPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8D7|||http://purl.uniprot.org/uniprot/A0A8J8XDU8|||http://purl.uniprot.org/uniprot/G7P1S6 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/9541:KIF2A ^@ http://purl.uniprot.org/uniprot/A0A2K5U740|||http://purl.uniprot.org/uniprot/A0A2K5U772 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:PGD ^@ http://purl.uniprot.org/uniprot/A0A2K5WBE9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/9541:LRRFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V262|||http://purl.uniprot.org/uniprot/A0A8J8Y1V3|||http://purl.uniprot.org/uniprot/G7NYL4 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/9541:LOC102137734 ^@ http://purl.uniprot.org/uniprot/A0A2K5V565|||http://purl.uniprot.org/uniprot/A0A8J8YNK8|||http://purl.uniprot.org/uniprot/G7Q1B2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CDK20 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||cilium http://togogenome.org/gene/9541:CD79B ^@ http://purl.uniprot.org/uniprot/G8F5R6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:TENT5D ^@ http://purl.uniprot.org/uniprot/A0A7N9DC55|||http://purl.uniprot.org/uniprot/G8F374 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9541:TBP ^@ http://purl.uniprot.org/uniprot/G7P4B0|||http://purl.uniprot.org/uniprot/Q4R4F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBP family.|||Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with UTF1. Interacts with BRF2; this interaction promotes recruitment of BRF2 to TATA box-containing promoters. Interacts with UBTF. Interacts with GPBP1. Interacts with CITED2. Interacts with ATF7IP. Interacts with LLPH. Interacts with HSF1 (via transactivation domain). Interacts with GTF2B (via C-terminus); this interaction with promoter-bound TBP guides RNA polymerase II into the pre-initiation complex (PIC). Interacts with PAX5 (By similarity). Interacts with MSX1; the interaction may inhibit MSX1 autoinactivation (By similarity).|||General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.|||Nucleus http://togogenome.org/gene/9541:TUBD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/9541:ACADS ^@ http://purl.uniprot.org/uniprot/A0A2K5U8K3|||http://purl.uniprot.org/uniprot/A0A7N9DAV7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:VANGL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ83|||http://purl.uniprot.org/uniprot/A0A8J8YP28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RPS27 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4U7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:SHTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W164|||http://purl.uniprot.org/uniprot/A0A2K5W1E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shootin family.|||Perikaryon|||axon|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9541:KPNA3 ^@ http://purl.uniprot.org/uniprot/I7GIR2 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:LETMD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAU8 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CALB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV88 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/9541:GPI ^@ http://purl.uniprot.org/uniprot/Q4R591 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPI family.|||Cytoplasm|||Homodimer; in the catalytically active form. Monomer in the secreted form.|||ISGylated.|||In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).|||Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.|||Secreted http://togogenome.org/gene/9541:TPRG1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CF06 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/9541:CCNE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJW9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKN4 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9541:ARL11 ^@ http://purl.uniprot.org/uniprot/G7PVF1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:EXOSC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR67 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SLC35E1 ^@ http://purl.uniprot.org/uniprot/G7PZQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXZ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/9541:ALAS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CHRDL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1H9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:TDO2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YL40|||http://purl.uniprot.org/uniprot/G7P6G7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102138187 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQN6|||http://purl.uniprot.org/uniprot/A0A2K5TQP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/9541:ACVR1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XB86|||http://purl.uniprot.org/uniprot/G7PKM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:NCBP2L ^@ http://purl.uniprot.org/uniprot/G7Q3F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/9541:MCM8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VML5|||http://purl.uniprot.org/uniprot/A0A2K5VMP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:PTEN ^@ http://purl.uniprot.org/uniprot/A0A2K5WAG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.|||Belongs to the PTEN phosphatase protein family.|||Cytoplasm|||Nucleus|||PML body|||Postsynaptic density|||dendritic spine http://togogenome.org/gene/9541:TMTC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7C9|||http://purl.uniprot.org/uniprot/A0A2K5V7E7|||http://purl.uniprot.org/uniprot/A0A7N9IGR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9541:LOC107129805 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBE1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9541:CACHD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIQ0 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/9541:DOCK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5M7|||http://purl.uniprot.org/uniprot/A0A2K5V671 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:LOC101865522 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZZ1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. http://togogenome.org/gene/9541:PIPOX ^@ http://purl.uniprot.org/uniprot/A0A2K5UKU2|||http://purl.uniprot.org/uniprot/A0A7N9CUM7 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/9541:RFC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPQ0 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9541:IFNK ^@ http://purl.uniprot.org/uniprot/G7PS65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9541:ILK ^@ http://purl.uniprot.org/uniprot/A0A2K5WGD3 ^@ Subcellular Location Annotation ^@ focal adhesion|||lamellipodium|||sarcomere http://togogenome.org/gene/9541:ABHD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRR1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/9541:DSTN ^@ http://purl.uniprot.org/uniprot/A0A2K5U939 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9541:SUPT6H ^@ http://purl.uniprot.org/uniprot/A0A8J8XF45|||http://purl.uniprot.org/uniprot/G7PTX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/9541:LOC102120655 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:LOC102120366 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBY3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:ZMYM5 ^@ http://purl.uniprot.org/uniprot/Q4R3D6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Functions as a transcriptional regulator.|||Interacts (via N-terminal 120 amino acid region) with ETV5 (via C-terminal).|||Nucleus http://togogenome.org/gene/9541:C14H11orf54 ^@ http://purl.uniprot.org/uniprot/A0A2K5X568 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/9541:TIGD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH83|||http://purl.uniprot.org/uniprot/G7P6F2|||http://purl.uniprot.org/uniprot/Q4R3E3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EIF2AK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXF2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9541:COPB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMC7|||http://purl.uniprot.org/uniprot/G7PQN7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Endoplasmic reticulum-Golgi intermediate compartment|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9541:HYOU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVL3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9541:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WER1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/9541:HACL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFK0 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/9541:NR2C2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DFG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:L1CAM ^@ http://purl.uniprot.org/uniprot/A0A2K5UR71|||http://purl.uniprot.org/uniprot/A0A2K5URA1|||http://purl.uniprot.org/uniprot/A0A2K5URB5 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9541:GRIK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6H7|||http://purl.uniprot.org/uniprot/A0A2K5X6J9|||http://purl.uniprot.org/uniprot/A0A2K5X6L2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:ETFA ^@ http://purl.uniprot.org/uniprot/A0A2K5UHW7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/9541:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:TIMM17A ^@ http://purl.uniprot.org/uniprot/A0A8J8XC83|||http://purl.uniprot.org/uniprot/G7NWE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ARG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUD1 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/9541:TRAM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W093 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/9541:LOC102136267 ^@ http://purl.uniprot.org/uniprot/Q8SPH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZI2|||http://purl.uniprot.org/uniprot/A0A2K5UZR6|||http://purl.uniprot.org/uniprot/A0A8J8XZT4|||http://purl.uniprot.org/uniprot/G7PHK8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:ATG7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y178|||http://purl.uniprot.org/uniprot/G7NYH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.|||Homodimer.|||Preautophagosomal structure http://togogenome.org/gene/9541:CRBN ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ62|||http://purl.uniprot.org/uniprot/G7NYW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/9541:AP3S2 ^@ http://purl.uniprot.org/uniprot/G7P9F6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/9541:SNCB ^@ http://purl.uniprot.org/uniprot/A0A2K5TQK0 ^@ Similarity ^@ Belongs to the synuclein family. http://togogenome.org/gene/9541:PEBP1 ^@ http://purl.uniprot.org/uniprot/P48737 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylethanolamine-binding protein family.|||Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).|||Cytoplasm|||HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity).|||Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade (By similarity). http://togogenome.org/gene/9541:LOC102118592 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWH6 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/9541:VEGFC ^@ http://purl.uniprot.org/uniprot/A0A2K5WBI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/9541:LOC102133037 ^@ http://purl.uniprot.org/uniprot/Q4R4D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm http://togogenome.org/gene/9541:NF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBX3|||http://purl.uniprot.org/uniprot/A0A2K5WC34|||http://purl.uniprot.org/uniprot/A0A2K5WC39 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9541:KEG98_p05 ^@ http://purl.uniprot.org/uniprot/C3W4Z3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:HIBCH ^@ http://purl.uniprot.org/uniprot/A0A2K5VSZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/9541:POLR1C ^@ http://purl.uniprot.org/uniprot/A0A2K5WSZ6|||http://purl.uniprot.org/uniprot/A0A7N9DE58 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/9541:STEAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTN5|||http://purl.uniprot.org/uniprot/A0A8J8YG83|||http://purl.uniprot.org/uniprot/G7P1U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:CENPM ^@ http://purl.uniprot.org/uniprot/A0A8J8XLD2|||http://purl.uniprot.org/uniprot/G7PFP3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SULT1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZW5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:PORCN ^@ http://purl.uniprot.org/uniprot/A0A2K5VCC3|||http://purl.uniprot.org/uniprot/A0A2K5VCF0|||http://purl.uniprot.org/uniprot/A0A2K5VCF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:STARD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9541:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQ66 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:LOC102120735 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMY4 ^@ Similarity ^@ Belongs to the SSX family. http://togogenome.org/gene/9541:LOC102119755 ^@ http://purl.uniprot.org/uniprot/A0A7N9D958 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9541:LOC102118223 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:GABRA6 ^@ http://purl.uniprot.org/uniprot/G7P6T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:TIMM21 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/9541:TTC30A ^@ http://purl.uniprot.org/uniprot/A0A2K5UG69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/9541:SLC7A7 ^@ http://purl.uniprot.org/uniprot/A0A7N9CP17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MMP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY24 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9541:LOC102134311 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRW3|||http://purl.uniprot.org/uniprot/G7PG07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:AKAP4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D580 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/9541:SCRN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDH9 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9541:ME2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDY8 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/9541:PRKAA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNP6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/9541:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/9541:METTL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8T9|||http://purl.uniprot.org/uniprot/A0A2K5X8U1 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/9541:MTF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIX9|||http://purl.uniprot.org/uniprot/I7G9R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9541:DUSP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/9541:SHMT2 ^@ http://purl.uniprot.org/uniprot/G7PIU7 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9541:AMOTL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4D9|||http://purl.uniprot.org/uniprot/A0A7N9CZ16|||http://purl.uniprot.org/uniprot/A0A7N9DDM7 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/9541:LOC102114898 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GLRA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBP3|||http://purl.uniprot.org/uniprot/G7P8R5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9541:FABP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YM21|||http://purl.uniprot.org/uniprot/G7P666 ^@ Function|||Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. http://togogenome.org/gene/9541:POLL ^@ http://purl.uniprot.org/uniprot/A0A8J8Y921|||http://purl.uniprot.org/uniprot/E5FGI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/9541:OVOL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IB29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CHAC2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D068|||http://purl.uniprot.org/uniprot/A0A8J8XXV5|||http://purl.uniprot.org/uniprot/G7PM72 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9541:LOC102124195 ^@ http://purl.uniprot.org/uniprot/A0A2K5X511 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/9541:SLC10A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBR1|||http://purl.uniprot.org/uniprot/A0A2K5VBV0|||http://purl.uniprot.org/uniprot/A0A8J8XN72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/9541:SULT1E1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSM8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:LOC102117755 ^@ http://purl.uniprot.org/uniprot/A0A7N9CEQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CREB3L4 ^@ http://purl.uniprot.org/uniprot/Q5UEM8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family. ATF subfamily.|||Binds DNA as a dimer.|||Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).|||Endoplasmic reticulum membrane|||Nucleus|||Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). http://togogenome.org/gene/9541:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Q8|||http://purl.uniprot.org/uniprot/G7Q3N2 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/9541:PEX2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9541:KCNH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ71 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HDAC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/9541:IGF2BP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Nucleus|||P-body|||Stress granule|||filopodium|||growth cone|||lamellipodium|||perinuclear region http://togogenome.org/gene/9541:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNA5|||http://purl.uniprot.org/uniprot/Q9N0A8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm|||Interacts with RHOA and RHOB. http://togogenome.org/gene/9541:ETFDH ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4W4|||http://purl.uniprot.org/uniprot/G7P6H5 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/9541:UBE2T ^@ http://purl.uniprot.org/uniprot/A0A2K5U653 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:UMPS ^@ http://purl.uniprot.org/uniprot/A0A2K5TYP5 ^@ Similarity ^@ In the C-terminal section; belongs to the OMP decarboxylase family.|||In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/9541:BRCA1 ^@ http://purl.uniprot.org/uniprot/A0A075VSV1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Cytoplasm|||E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.|||Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.|||Nucleus http://togogenome.org/gene/9541:AVIL ^@ http://purl.uniprot.org/uniprot/A0A2K5US22 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/9541:AOC2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2F1|||http://purl.uniprot.org/uniprot/G7PUW5 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/9541:KRT222 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLD5|||http://purl.uniprot.org/uniprot/G7PUP3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:GJD2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLU2|||http://purl.uniprot.org/uniprot/G7PAP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:CANT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTK9|||http://purl.uniprot.org/uniprot/G7PT20 ^@ Similarity ^@ Belongs to the apyrase family. http://togogenome.org/gene/9541:EZR ^@ http://purl.uniprot.org/uniprot/A0A2K5W6F0 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/9541:PHC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF17 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:JPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RASGRP2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIC2 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/9541:UBE2D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRH8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:A1CF ^@ http://purl.uniprot.org/uniprot/A0A2K5VBN3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:LOC102133117 ^@ http://purl.uniprot.org/uniprot/A0A7N9D7R8 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/9541:MED31 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGZ2|||http://purl.uniprot.org/uniprot/G7PTE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9541:LOC102141409 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG65|||http://purl.uniprot.org/uniprot/A0A2K5WUP0|||http://purl.uniprot.org/uniprot/A0A7N9CCJ9 ^@ Similarity ^@ Belongs to the peptidase M17 family.|||Belongs to the syntaxin family. http://togogenome.org/gene/9541:SLC29A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/9541:MARF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUD8 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/9541:PTGDR ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1H0|||http://purl.uniprot.org/uniprot/G7PA94 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:PRKCH ^@ http://purl.uniprot.org/uniprot/A0A2K5UP58 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation. http://togogenome.org/gene/9541:RHCG ^@ http://purl.uniprot.org/uniprot/A0A8J8XKZ0|||http://purl.uniprot.org/uniprot/G7P9E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/9541:ALDOC ^@ http://purl.uniprot.org/uniprot/A0A805Q5V7|||http://purl.uniprot.org/uniprot/G7PTX4|||http://purl.uniprot.org/uniprot/Q9GKW3 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class I fructose-bisphosphate aldolase family.|||Homotetramer. Interacts with ATP6V1E1.|||In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain. http://togogenome.org/gene/9541:GPRC5A ^@ http://purl.uniprot.org/uniprot/A0A2K5V8R6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:MYO1D ^@ http://purl.uniprot.org/uniprot/A0A2K5V6Z7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:HBS1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WCP7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TRIAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDY0 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/9541:ACMSD ^@ http://purl.uniprot.org/uniprot/A0A7N9CFZ9|||http://purl.uniprot.org/uniprot/A0A7N9IB17|||http://purl.uniprot.org/uniprot/A0A8J8YBQ4|||http://purl.uniprot.org/uniprot/G7PN37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/9541:NKG7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9541:USP30 ^@ http://purl.uniprot.org/uniprot/A0A8J8XM81|||http://purl.uniprot.org/uniprot/G7PI60 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:GABRG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W162 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:SLC6A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.|||Cell membrane|||Interacts with LIN7C.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9541:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X956 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:DYNLRB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UM23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9541:DDIT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSM5|||http://purl.uniprot.org/uniprot/G7PIV4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Cytoplasm|||Heterodimer.|||Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.|||Nucleus|||Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.|||Ubiquitinated, leading to its degradation by the proteasome. http://togogenome.org/gene/9541:KCNK17 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:PLA2G15 ^@ http://purl.uniprot.org/uniprot/A0A2K5X057 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9541:HIKESHI ^@ http://purl.uniprot.org/uniprot/A0A2K5V9R3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/9541:TM9SF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9541:EEF1A1 ^@ http://purl.uniprot.org/uniprot/Q4R5K0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/9541:TENM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2F0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:STX5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XE24|||http://purl.uniprot.org/uniprot/G7PPS5 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:SLC39A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0P7|||http://purl.uniprot.org/uniprot/A0A7N9CFY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GJA4 ^@ http://purl.uniprot.org/uniprot/G7NTG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:STXBP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X901 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:LOC102147203 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYP0 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9541:NSFL1C ^@ http://purl.uniprot.org/uniprot/A0A2K5VJE4|||http://purl.uniprot.org/uniprot/A0A2K5VJS2 ^@ Subcellular Location Annotation|||Subunit ^@ Golgi stack|||Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP. http://togogenome.org/gene/9541:RFC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN91 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/9541:CD52 ^@ http://purl.uniprot.org/uniprot/P32763 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||May play a role in carrying and orienting carbohydrate, as well as having a more specific role. http://togogenome.org/gene/9541:EIF1AD ^@ http://purl.uniprot.org/uniprot/Q4R354 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Nucleus|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity). http://togogenome.org/gene/9541:LOC102141103 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH18 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family.|||Monomer. http://togogenome.org/gene/9541:CIAO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. http://togogenome.org/gene/9541:TFF2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9T8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:THRB ^@ http://purl.uniprot.org/uniprot/A0A2K5UEL1|||http://purl.uniprot.org/uniprot/A0A2K5V0F5|||http://purl.uniprot.org/uniprot/A0A8J8XIM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:NEK6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIW9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:NNT ^@ http://purl.uniprot.org/uniprot/A0A2K5WQE6 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/9541:ATP1A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV79 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:GNAS ^@ http://purl.uniprot.org/uniprot/Q2PFZ8 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/9541:LLPH ^@ http://purl.uniprot.org/uniprot/A0A2K5X0J3 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/9541:POU2F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6C1|||http://purl.uniprot.org/uniprot/A0A2K5W6C9|||http://purl.uniprot.org/uniprot/A0A8J8XNY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus|||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. http://togogenome.org/gene/9541:CSRNP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8N7|||http://purl.uniprot.org/uniprot/A0A7N9CWX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9541:DGUOK ^@ http://purl.uniprot.org/uniprot/A0A2K5VPR5|||http://purl.uniprot.org/uniprot/A0A8J8Y974|||http://purl.uniprot.org/uniprot/G7PMI3 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/9541:TMEM70 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGT8 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/9541:SERPINB13 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAP2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A2K5U9A3|||http://purl.uniprot.org/uniprot/A0A2K5U9C5 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/9541:PRPS1L1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CH96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/9541:LOC102136630 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI22 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/9541:DPYSL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTE7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9541:RP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:COQ8A ^@ http://purl.uniprot.org/uniprot/A0A2K5VRC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane http://togogenome.org/gene/9541:HS3ST2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNA8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:PPP1CC ^@ http://purl.uniprot.org/uniprot/A0A2K5WK94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:WAS ^@ http://purl.uniprot.org/uniprot/A0A2K5U1L0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HTR1D ^@ http://purl.uniprot.org/uniprot/A0A2K5UMI0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homodimer. Heterodimer with HTR1B.|||Membrane http://togogenome.org/gene/9541:CA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCT8 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:CCDC89 ^@ http://purl.uniprot.org/uniprot/Q95JI9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC89 family.|||Cytoplasm|||Interacts with HEY1.|||Nucleus http://togogenome.org/gene/9541:APTX ^@ http://purl.uniprot.org/uniprot/Q9BGQ0 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).|||Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT/PARP1 and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).|||The C2H2-type zinc finger mediates DNA-binding.|||The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4.|||The HIT domain is required for enzymatic activity.|||The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:NMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEF7 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/9541:BCL2L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPG2|||http://purl.uniprot.org/uniprot/A0A7N9D351 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/9541:HNRNPC ^@ http://purl.uniprot.org/uniprot/A0A2K5U148 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/9541:GET3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/9541:FOXH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EPC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEL3|||http://purl.uniprot.org/uniprot/A0A2K5WEN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9541:YAF2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQ30 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:KCNMB4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CUG2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/9541:P4HA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:MRPL40 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSK4|||http://purl.uniprot.org/uniprot/G7PH82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/9541:PDGFB ^@ http://purl.uniprot.org/uniprot/A0A2K5UX81 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9541:LOC102146887 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystatin family.|||Secreted http://togogenome.org/gene/9541:EIF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX53 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/9541:AMIGO1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XXM3|||http://purl.uniprot.org/uniprot/G7NV59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9541:CCL28 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBT9|||http://purl.uniprot.org/uniprot/G7P7G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:SLC10A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCL6|||http://purl.uniprot.org/uniprot/A0A2K5UCM4|||http://purl.uniprot.org/uniprot/A0A2K5UCN6|||http://purl.uniprot.org/uniprot/A0A2K5UCN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Cell membrane|||Does not show transport activity towards bile acids or steroid sulfates.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/9541:DOCK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVL2 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:RNF182 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJU3|||http://purl.uniprot.org/uniprot/G7P4G4 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/9541:BAZ2A ^@ http://purl.uniprot.org/uniprot/A0A2K5UPU3|||http://purl.uniprot.org/uniprot/A0A2K5UPV6 ^@ Similarity ^@ Belongs to the WAL family. http://togogenome.org/gene/9541:USP20 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/9541:LOC102126513 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9541:GTF2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/9541:LOC102128296 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBG0|||http://purl.uniprot.org/uniprot/A0A2K5UH45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9541:HEPH ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ73|||http://purl.uniprot.org/uniprot/G7Q2X1 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/9541:LOC102120368 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN85 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SPIN4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5W0|||http://purl.uniprot.org/uniprot/G7Q2W1 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9541:PRRX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9541:IFNA8 ^@ http://purl.uniprot.org/uniprot/G7PS89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/9541:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY45 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:MAU2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC4/mau-2 family.|||nucleoplasm http://togogenome.org/gene/9541:EIF3M ^@ http://purl.uniprot.org/uniprot/A0A2K5TRB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/9541:TLCD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUC6|||http://purl.uniprot.org/uniprot/A0A7N9IBL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A2K5VXR6|||http://purl.uniprot.org/uniprot/A0A2K5VXV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EMC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5W141 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9541:SPINK2 ^@ http://purl.uniprot.org/uniprot/P34953 ^@ Function|||Subcellular Location Annotation|||Tissue Specificity ^@ As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (By similarity). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin (By similarity).|||More abundant in epididymis than in testis.|||Secreted|||Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin (By similarity).|||acrosome http://togogenome.org/gene/9541:LOC102144154 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9A2|||http://purl.uniprot.org/uniprot/G8F4K7 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:SYT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJ11|||http://purl.uniprot.org/uniprot/G7NWD9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||synaptic vesicle membrane http://togogenome.org/gene/9541:F11R ^@ http://purl.uniprot.org/uniprot/I7GN79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/9541:LOC102121277 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG77 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9541:NR0B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RTRAF ^@ http://purl.uniprot.org/uniprot/A0A8J8XBC5|||http://purl.uniprot.org/uniprot/G7PA92 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/9541:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ99|||http://purl.uniprot.org/uniprot/A0A2K5VQF2|||http://purl.uniprot.org/uniprot/A0A7N9IBE8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TMEM234 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/9541:PPP1R10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGH1|||http://purl.uniprot.org/uniprot/G7P4L7 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/9541:PROC ^@ http://purl.uniprot.org/uniprot/A0A2K5VQK4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:RIBC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKB8|||http://purl.uniprot.org/uniprot/G7Q2T0 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/9541:GPR12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TP16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CEMIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3E0|||http://purl.uniprot.org/uniprot/A0A2K5W3F2 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/9541:BRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U738 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIB family.|||Nucleus http://togogenome.org/gene/9541:HSD11B1L ^@ http://purl.uniprot.org/uniprot/Q6Q7D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Secreted http://togogenome.org/gene/9541:LOC102120741 ^@ http://purl.uniprot.org/uniprot/G7P2L6|||http://purl.uniprot.org/uniprot/G7P2P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:INSL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ81 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:RPS21 ^@ http://purl.uniprot.org/uniprot/A0A2K5U026 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/9541:LOC101866303 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZS8|||http://purl.uniprot.org/uniprot/A0A8J8XJ50 ^@ Similarity ^@ Belongs to the PRAME family. http://togogenome.org/gene/9541:TKTL1 ^@ http://purl.uniprot.org/uniprot/Q4R6M8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/9541:IFT43 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSQ0 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/9541:FSHB ^@ http://purl.uniprot.org/uniprot/G7PQH7|||http://purl.uniprot.org/uniprot/Q6EV79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.|||Secreted|||Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:10612425). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (By similarity). http://togogenome.org/gene/9541:NFE2L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9I7 ^@ Similarity ^@ Belongs to the bZIP family. CNC subfamily. http://togogenome.org/gene/9541:MTIF2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CHK0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/9541:NAV2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYX2|||http://purl.uniprot.org/uniprot/A0A2K5TYZ0 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/9541:ERLEC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBT2|||http://purl.uniprot.org/uniprot/G7PM73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9541:EP300 ^@ http://purl.uniprot.org/uniprot/A0A8J8XI68|||http://purl.uniprot.org/uniprot/G7PFM4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:CAMK2N1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVX6 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/9541:PKLR ^@ http://purl.uniprot.org/uniprot/A0A2K5WL75 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9541:INSL5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP35|||http://purl.uniprot.org/uniprot/G7NW30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9541:MED9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:SCD ^@ http://purl.uniprot.org/uniprot/A0A2K5TPH0|||http://purl.uniprot.org/uniprot/G7PDR3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9541:MFSD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQX5|||http://purl.uniprot.org/uniprot/A0A7N9CQR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/9541:LOC102141433 ^@ http://purl.uniprot.org/uniprot/A0A7N9DET8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ARV1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFP4|||http://purl.uniprot.org/uniprot/G7NXK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/9541:HEXIM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBN7|||http://purl.uniprot.org/uniprot/G7PV18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9541:LY6G5C ^@ http://purl.uniprot.org/uniprot/A0A7N9CQK9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Forms oligomers.|||May have a role in hematopoietic cell differentiation.|||Secreted http://togogenome.org/gene/9541:TBX15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLD0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:CERS6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS77|||http://purl.uniprot.org/uniprot/A0A7N9DG37|||http://purl.uniprot.org/uniprot/A0A8J8YJ84 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:SERPINB7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBF3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:H1-2 ^@ http://purl.uniprot.org/uniprot/G7P2L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:ATP2B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4W6|||http://purl.uniprot.org/uniprot/A0A2K5U4Y2|||http://purl.uniprot.org/uniprot/A0A2K5U4Y5|||http://purl.uniprot.org/uniprot/A0A2K5U535 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:HHIPL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2J6 ^@ Similarity ^@ Belongs to the HHIP family. http://togogenome.org/gene/9541:NIF3L1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNX5|||http://purl.uniprot.org/uniprot/G7PL60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/9541:AURKA ^@ http://purl.uniprot.org/uniprot/A0A2K5TW98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/9541:DDX3X ^@ http://purl.uniprot.org/uniprot/A0A2K5UCB3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:PARP11 ^@ http://purl.uniprot.org/uniprot/A0A2K5U101|||http://purl.uniprot.org/uniprot/A0A2K5U114|||http://purl.uniprot.org/uniprot/A0A2K5U124 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:GANAB ^@ http://purl.uniprot.org/uniprot/A0A2K5VUH9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/9541:PLA2G5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7P1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:HOOK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/9541:GJC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:AFG1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WWA7|||http://purl.uniprot.org/uniprot/A0A7N9DCI3 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/9541:GSTCD ^@ http://purl.uniprot.org/uniprot/A0A2K5X8G8 ^@ Similarity ^@ Belongs to the GSTCD family. http://togogenome.org/gene/9541:RAB9B ^@ http://purl.uniprot.org/uniprot/A0A8J8YIR9|||http://purl.uniprot.org/uniprot/G7Q3C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9541:N4BP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Vesicle|||dendrite http://togogenome.org/gene/9541:CNOT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFT7|||http://purl.uniprot.org/uniprot/G7PI14 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/9541:EMC8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFV4|||http://purl.uniprot.org/uniprot/A0A8J8YKW4|||http://purl.uniprot.org/uniprot/G7PZW7 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/9541:ELOVL6 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0S2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/9541:LOC102121500 ^@ http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:GCAT ^@ http://purl.uniprot.org/uniprot/I7GL53 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:CIT ^@ http://purl.uniprot.org/uniprot/A0A2K5U1S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Plays a role in cytokinesis. Displays serine/threonine protein kinase activity. http://togogenome.org/gene/9541:CD81 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:RFPL4B ^@ http://purl.uniprot.org/uniprot/G7P3M3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SNCA ^@ http://purl.uniprot.org/uniprot/G7P5X2|||http://purl.uniprot.org/uniprot/P61142 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.|||Belongs to the synuclein family.|||Cytoplasm|||Membrane|||Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity).|||Nucleus|||Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress.|||Secreted|||Soluble monomer. Homotetramer. A dynamic intracellular population of tetramers and monomers coexists normally and the tetramer plays an essential role in maintaining homeostasis (By similarity). Interacts with UCHL1 (By similarity). Interacts with phospholipase D and histones. Interacts (via N-terminus) with synphilin-1/SNCAIP; this interaction promotes formation of SNCA inclusions in the cytoplasm. Interacts with CALM1. Interacts with STXBP1; this interaction controls SNCA self-replicating aggregation. Interacts with SNARE components VAMP2 and SNAP25; these interactions allows SNARE complex assembly and integrity (By similarity). Interacts with RPH3A and RAB3A (By similarity). Interacts with SERF1A; this interaction promotes the aggregation of SNCA (By similarity). Interacts with SEPTIN4 (By similarity).|||Synapse|||Ubiquitinated. The predominant conjugate is the diubiquitinated form.|||axon http://togogenome.org/gene/9541:LOC107126377 ^@ http://purl.uniprot.org/uniprot/A0A8U0WQ25|||http://purl.uniprot.org/uniprot/G8F3V0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:NDUFS8 ^@ http://purl.uniprot.org/uniprot/G7PP61|||http://purl.uniprot.org/uniprot/Q60HE3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] cluster.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Interacts with RAB5IF (By similarity).|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for the catalytic activity and assembly of complex I (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC101867156 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCF7|||http://purl.uniprot.org/uniprot/G7P9V7 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9541:RORB ^@ http://purl.uniprot.org/uniprot/A0A2K5WSZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:SEPTIN1 ^@ http://purl.uniprot.org/uniprot/G7Q0X5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:DCLK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP49|||http://purl.uniprot.org/uniprot/A0A2K5UP70|||http://purl.uniprot.org/uniprot/A0A8J8XX00 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:GC ^@ http://purl.uniprot.org/uniprot/A0A2K5V1W9 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/9541:LOC101867207 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2K7 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M18 family.|||Tetrahedron-shaped homododecamer built from six homodimers. http://togogenome.org/gene/9541:KCNA10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGF0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6A3|||http://purl.uniprot.org/uniprot/A0A2K5U6B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/9541:BLOC1S1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BLOC1S1 family.|||Lysosome membrane|||May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:SCN3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VS58|||http://purl.uniprot.org/uniprot/A0A2K5VS92 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9541:KRT37 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGF7|||http://purl.uniprot.org/uniprot/G7PUR8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:DPH5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5Q4|||http://purl.uniprot.org/uniprot/G7NV35 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/9541:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXY5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:EID2B ^@ http://purl.uniprot.org/uniprot/G7PXK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SMC1A ^@ http://purl.uniprot.org/uniprot/A0A8J8XR42|||http://purl.uniprot.org/uniprot/G7Q2S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:ZKSCAN1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CR92 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TMCC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTR9|||http://purl.uniprot.org/uniprot/G7PIM5 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9541:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6M7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A2K5W8T8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.|||Cell membrane|||Cytoplasm|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||cytoskeleton|||perinuclear region http://togogenome.org/gene/9541:NSDHL ^@ http://purl.uniprot.org/uniprot/A0A2K5UDV0 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9541:SBNO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZM4|||http://purl.uniprot.org/uniprot/A0A2K5UZV1 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/9541:EXOSC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/9541:LOC102123651 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRE9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:MNAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA85|||http://purl.uniprot.org/uniprot/A0A2K5UA91 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/9541:IAH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY2|||http://purl.uniprot.org/uniprot/A0A7N9DFY3 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/9541:TMEM47 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/9541:CD93 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH53 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/G7P190 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ACTN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVV0|||http://purl.uniprot.org/uniprot/A0A2K5VVZ5 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9541:LOC102133014 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8U4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.|||Belongs to the osteocalcin/matrix Gla protein family.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Requires vitamin K-dependent gamma-carboxylation for its function.|||Secreted http://togogenome.org/gene/9541:LOC102144907 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGW3 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/9541:SMU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W168 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/9541:LOC102143204 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHA3|||http://purl.uniprot.org/uniprot/G7PET2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CSTF2T ^@ http://purl.uniprot.org/uniprot/G8F2J6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:B4GALT3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVR9|||http://purl.uniprot.org/uniprot/G7NXA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9541:CDK8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7E0|||http://purl.uniprot.org/uniprot/G7PVW1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN99|||http://purl.uniprot.org/uniprot/A0A2K5VNE6|||http://purl.uniprot.org/uniprot/A0A7N9ID98 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:NDUFAF7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/9541:GPSM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYJ0|||http://purl.uniprot.org/uniprot/G7NV46 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/9541:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTM8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9541:HSPB7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE10|||http://purl.uniprot.org/uniprot/A0A7N9IBP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/9541:C18H18orf32 ^@ http://purl.uniprot.org/uniprot/I7G4M0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UPF0729 family.|||Interacts with DERL1 and AMFR.|||Lipid droplet|||May activate the NF-kappa-B signaling pathway. http://togogenome.org/gene/9541:KDELR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZJ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:MAPT ^@ http://purl.uniprot.org/uniprot/A0A2K5WB83 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||axon|||cytoskeleton|||cytosol|||dendrite http://togogenome.org/gene/9541:GPHN ^@ http://purl.uniprot.org/uniprot/A0A2K5TLW2|||http://purl.uniprot.org/uniprot/A0A2K5TLW8|||http://purl.uniprot.org/uniprot/A0A2K5TLX8|||http://purl.uniprot.org/uniprot/A0A2K5TLY1 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.|||In the C-terminal section; belongs to the MoeA family.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/9541:CCR4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLQ0|||http://purl.uniprot.org/uniprot/G7NYB7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:IFIT1 ^@ http://purl.uniprot.org/uniprot/Q4R5F5 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IFIT family.|||Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT2 and IFIT3 (By similarity). Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts (via TPR repeats 1-4) with RPL15 (By similarity). Interacts with STING1/MITA and disrupts its interaction with MAVS or TBK1 (By similarity). Interacts with EIF3C and EIF3E (By similarity).|||Cytoplasm|||ISGylated.|||Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism) (By similarity).|||Phosphorylated.|||RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft. http://togogenome.org/gene/9541:OSBPL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIC3|||http://purl.uniprot.org/uniprot/A0A2K5VII1|||http://purl.uniprot.org/uniprot/A0A2K5VIN8 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:NCF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U677 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/9541:ALKBH5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU23 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkB family.|||Monomer.|||Nucleus speckle http://togogenome.org/gene/9541:UBA5 ^@ http://purl.uniprot.org/uniprot/A0A7N9CUJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.|||Endoplasmic reticulum membrane|||Golgi apparatus http://togogenome.org/gene/9541:NOL10 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFH0|||http://purl.uniprot.org/uniprot/G7PLL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/9541:CBX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FAM3C ^@ http://purl.uniprot.org/uniprot/A0A2K5VE88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9541:AKTIP ^@ http://purl.uniprot.org/uniprot/Q4R5E1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.|||Cell membrane|||Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FHIP1B, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. Interacts directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1. May interact with FHIP1A.|||Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.|||Cytoplasm|||Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity. http://togogenome.org/gene/9541:CASD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PC-esterase family. CASD1 subfamily.|||Membrane http://togogenome.org/gene/9541:PSMD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0W1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/9541:G6PC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:CLIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIR8|||http://purl.uniprot.org/uniprot/A0A2K5VIS5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:ZDHHC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWE7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:ING2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZX0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9541:VTA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMP1|||http://purl.uniprot.org/uniprot/G7P314 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:VPS35 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXX7 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/9541:EDN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9541:KARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZR2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:TMEM182 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3P3|||http://purl.uniprot.org/uniprot/A0A7N9CPH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102145938 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4K0 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:AWAT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTH0|||http://purl.uniprot.org/uniprot/G7Q2Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:LOC102140788 ^@ http://purl.uniprot.org/uniprot/G7P624|||http://purl.uniprot.org/uniprot/P61256 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Component of the large ribosomal subunit. Interacts with DHX33.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets. http://togogenome.org/gene/9541:TWSG1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIC6|||http://purl.uniprot.org/uniprot/G7PWD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/9541:MGAT4C ^@ http://purl.uniprot.org/uniprot/Q4R4A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).|||Golgi apparatus membrane http://togogenome.org/gene/9541:SIKE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V835|||http://purl.uniprot.org/uniprot/A0A7N9CJ40 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/9541:ASB11 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1E1|||http://purl.uniprot.org/uniprot/A0A2K5W1E6 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:DLK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMQ6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MAPK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXF6 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||caveola|||focal adhesion http://togogenome.org/gene/9541:GPR161 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLY0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:RHBDL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5G2|||http://purl.uniprot.org/uniprot/A0A2K5U5J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9541:TADA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y822|||http://purl.uniprot.org/uniprot/G7NU37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/9541:YPEL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCK4 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9541:LOC102141746 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PHKB ^@ http://purl.uniprot.org/uniprot/A0A2K5VG98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/9541:CLSTN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calsyntenin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Postsynaptic cell membrane http://togogenome.org/gene/9541:DNAJC18 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS89 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:INTS12 ^@ http://purl.uniprot.org/uniprot/G7P614|||http://purl.uniprot.org/uniprot/Q8WNV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Integrator subunit 12 family.|||Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.|||Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.|||Nucleus http://togogenome.org/gene/9541:CPNE8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YL94|||http://purl.uniprot.org/uniprot/G7PHL3 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:SUB1 ^@ http://purl.uniprot.org/uniprot/Q25NQ4|||http://purl.uniprot.org/uniprot/Q4R947 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA (By similarity).|||Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity).|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Homodimer. Interacts with CSTF2 (By similarity).|||Homodimer. Interacts with CSTF2.|||Nucleus http://togogenome.org/gene/9541:STAG1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEF3|||http://purl.uniprot.org/uniprot/G7NXX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9541:ELK3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAT6|||http://purl.uniprot.org/uniprot/G7PJ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:KEG98_p04 ^@ http://purl.uniprot.org/uniprot/C3W4Z4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:ACADL ^@ http://purl.uniprot.org/uniprot/A0A7N9D315 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/9541:EIF4G1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFX9 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4G family. http://togogenome.org/gene/9541:EHD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6F2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:TCTN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYQ3 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/9541:MRPS18B ^@ http://purl.uniprot.org/uniprot/A0A7N9CYI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.|||Mitochondrion http://togogenome.org/gene/9541:ZSCAN12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PRRT2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DDH4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/9541:UGCG ^@ http://purl.uniprot.org/uniprot/A0A2K5WQV5 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9541:DDX50 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK31 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/9541:PIP4P2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN62 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9541:LOC102124556 ^@ http://purl.uniprot.org/uniprot/G7P1K9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:SNTG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/9541:CCL27 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9R6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTC8|||http://purl.uniprot.org/uniprot/A0A2K5VTE3|||http://purl.uniprot.org/uniprot/A0A8J8YLN9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9541:LOC102140676 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CABIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWI8|||http://purl.uniprot.org/uniprot/A0A2K5VWX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RPL12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBV0|||http://purl.uniprot.org/uniprot/G8F4M8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/9541:MMP14 ^@ http://purl.uniprot.org/uniprot/A0A8J8XW92|||http://purl.uniprot.org/uniprot/G7P9U2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||Cytoplasm|||Melanosome http://togogenome.org/gene/9541:NDUFA4 ^@ http://purl.uniprot.org/uniprot/Q4R542 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex IV NDUFA4 subunit family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Interacts with RAB5IF (By similarity). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. NDUFA4 is required for complex IV maintenance.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:RDH8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHB7|||http://purl.uniprot.org/uniprot/G7PZ59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/9541:TIMM8B ^@ http://purl.uniprot.org/uniprot/G7PNT5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9541:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/I7G790 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9541:USP45 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNX1 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:LOC102134176 ^@ http://purl.uniprot.org/uniprot/Q9TSM6 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the protein-tyrosine phosphatase family.|||Cell membrane|||Cytoplasm|||Early endosome|||Endoplasmic reticulum|||Farnesylated. Farnesylation is required for membrane targeting (By similarity).|||Homotrimer. Interacts with ATF5 and tubulin (By similarity).|||In the retina, expressed by red/green- but not blue-sensitive cone photoreceptor cells, and by rod bipolar cells (at protein level).|||Inhibited by sodium orthovanadate and pentamidine.|||Nucleus|||Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).|||spindle http://togogenome.org/gene/9541:MEIG1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDF9|||http://purl.uniprot.org/uniprot/G7PEF2 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/9541:MED30 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9541:COPG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/9541:RDH5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRR1|||http://purl.uniprot.org/uniprot/G7PIF1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:MMP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5A4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit.|||extracellular matrix http://togogenome.org/gene/9541:AK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMF2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/9541:SLC35F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VES8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9541:YKT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBW3|||http://purl.uniprot.org/uniprot/A0A7N9IDJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/9541:STAT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W338 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:INKA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR15|||http://purl.uniprot.org/uniprot/A0A7N9D0M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/9541:IDNK ^@ http://purl.uniprot.org/uniprot/A0A2K5UJQ4 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/9541:NEU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS75 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/9541:PDE7A ^@ http://purl.uniprot.org/uniprot/A0A2K5WGM8|||http://purl.uniprot.org/uniprot/A0A8J8XNN1|||http://purl.uniprot.org/uniprot/G7PBY0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:SARM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SARM1 family.|||axon http://togogenome.org/gene/9541:LOC102122186 ^@ http://purl.uniprot.org/uniprot/G7P0E5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SCD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2B7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/9541:LOC102127157 ^@ http://purl.uniprot.org/uniprot/G8F5F7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NSMCE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/9541:NLK ^@ http://purl.uniprot.org/uniprot/A0A7N9IE49|||http://purl.uniprot.org/uniprot/A0A8J8Y4V7|||http://purl.uniprot.org/uniprot/G7PTW3 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9541:NMI ^@ http://purl.uniprot.org/uniprot/A0A2K5VU13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9541:GK5 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBB2 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9541:CDA ^@ http://purl.uniprot.org/uniprot/A0A2K5TSB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Cytoplasm|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/9541:RORC ^@ http://purl.uniprot.org/uniprot/A0A2K5UAQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:TMEM54 ^@ http://purl.uniprot.org/uniprot/A0A2K5U810 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/9541:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V402 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/9541:CLDN12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UH12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/9541:NTSR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102134374 ^@ http://purl.uniprot.org/uniprot/G7P6T4|||http://purl.uniprot.org/uniprot/Q4R6P8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Component of the small ribosomal subunit. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.|||Cytoplasm|||Membrane|||nucleolus http://togogenome.org/gene/9541:IL2RG ^@ http://purl.uniprot.org/uniprot/A0A2K5VGJ6|||http://purl.uniprot.org/uniprot/A0A8J8XHR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SERPIND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTW1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:ATP5MC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Z4|||http://purl.uniprot.org/uniprot/G7P524 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9541:LOC102120351 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5F7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:CRYBB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY4 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:SEPSECS ^@ http://purl.uniprot.org/uniprot/A0A2K5WAA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/9541:PIK3CG ^@ http://purl.uniprot.org/uniprot/A0A2K5V7M8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:SLC35E2B ^@ http://purl.uniprot.org/uniprot/A0A2K5TL70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102143578 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKJ2|||http://purl.uniprot.org/uniprot/A0A8J8YDL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/9541:TAF6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMH2|||http://purl.uniprot.org/uniprot/G7P0C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/9541:FLOT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNG8|||http://purl.uniprot.org/uniprot/G7P4M4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/9541:USP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA78 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:TMEM147 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM147 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane|||Nucleus membrane http://togogenome.org/gene/9541:CTSW ^@ http://purl.uniprot.org/uniprot/A0A2K5TYS6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9541:SERPINA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSD9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKS8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/9541:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A2K5VI33 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/9541:CRK ^@ http://purl.uniprot.org/uniprot/A0A2K5X7X9 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9541:CLCN2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAS7|||http://purl.uniprot.org/uniprot/G7NYZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RPS9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSV3|||http://purl.uniprot.org/uniprot/G7PYS4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/9541:NPPB ^@ http://purl.uniprot.org/uniprot/A0A2K5V0K8|||http://purl.uniprot.org/uniprot/G8F4Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9541:NR2E1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:PIR ^@ http://purl.uniprot.org/uniprot/A0A2K5V2H4|||http://purl.uniprot.org/uniprot/G7Q298 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/9541:RPN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UST6|||http://purl.uniprot.org/uniprot/A0A2K5USU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9541:NGB ^@ http://purl.uniprot.org/uniprot/A0A7N9CWQ6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:LOC102147033 ^@ http://purl.uniprot.org/uniprot/A0A7N9CD12 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:STAC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQY8 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/9541:SULT1C4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X358 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:CAVIN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/9541:TNNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBC9|||http://purl.uniprot.org/uniprot/A0A2K5WBT9 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/9541:OSBPL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT73|||http://purl.uniprot.org/uniprot/A0A2K5U737 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:GGCX ^@ http://purl.uniprot.org/uniprot/A0A8J8XEH1|||http://purl.uniprot.org/uniprot/G7PMM1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LRRC8C ^@ http://purl.uniprot.org/uniprot/A0A8J8YIA7|||http://purl.uniprot.org/uniprot/G7NTM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ABAT ^@ http://purl.uniprot.org/uniprot/A0A2K5UZZ0 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9541:TMEM266 ^@ http://purl.uniprot.org/uniprot/Q9N0B5 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Homodimer; disulfide-linked.|||Perikaryon|||The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Transplantation of the transmembrane segment S4 into HVCN1, generates a functional voltage-activated proton channel.|||Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.|||dendrite http://togogenome.org/gene/9541:SKAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5C8|||http://purl.uniprot.org/uniprot/A0A979HKE4 ^@ Similarity ^@ Belongs to the SKAP family. http://togogenome.org/gene/9541:VAPB ^@ http://purl.uniprot.org/uniprot/A0A2K5WHF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:MFNG ^@ http://purl.uniprot.org/uniprot/A0A7N9I9E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6X7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9541:NKAPL ^@ http://purl.uniprot.org/uniprot/A0A7N9CJD0 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/9541:CRB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN44|||http://purl.uniprot.org/uniprot/A0A8J8Y5Q7|||http://purl.uniprot.org/uniprot/G7NWI2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TAS2R10 ^@ http://purl.uniprot.org/uniprot/A0A7N9CV58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:RCAN3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCU2|||http://purl.uniprot.org/uniprot/G7NVW0 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/9541:LOC102123081 ^@ http://purl.uniprot.org/uniprot/Q4R3H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||Tubulin-folding protein; involved in the early step of the tubulin folding pathway.|||cytoskeleton http://togogenome.org/gene/9541:PDE3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VAH0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:PDC ^@ http://purl.uniprot.org/uniprot/A0A2K5U750 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9541:PLAC1 ^@ http://purl.uniprot.org/uniprot/G7Q1Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PLAC1 family.|||Secreted http://togogenome.org/gene/9541:RPL26 ^@ http://purl.uniprot.org/uniprot/G7P624|||http://purl.uniprot.org/uniprot/P61256 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Component of the large ribosomal subunit. Interacts with DHX33.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets. http://togogenome.org/gene/9541:MAF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHI8|||http://purl.uniprot.org/uniprot/G7PDA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/9541:GCNT2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CM24|||http://purl.uniprot.org/uniprot/A0A8J8Y4A2|||http://purl.uniprot.org/uniprot/G7P4D9 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:TMCC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6U3 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/9541:STING1 ^@ http://purl.uniprot.org/uniprot/A0A2R3XZA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STING family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Mitochondrion outer membrane|||autophagosome membrane|||perinuclear region http://togogenome.org/gene/9541:LOC102121015 ^@ http://purl.uniprot.org/uniprot/A0A7N9CR08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:DLAT ^@ http://purl.uniprot.org/uniprot/A0A2K5UNA0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Mitochondrion matrix|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/9541:RDH10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW13 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:SNRPN ^@ http://purl.uniprot.org/uniprot/Q25QJ5|||http://purl.uniprot.org/uniprot/Q60HD3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP SmB/SmN family.|||Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.|||Interacts with TDRD3.|||May be involved in tissue-specific alternative RNA processing events.|||Nucleus http://togogenome.org/gene/9541:E2F7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X799 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:ANAPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X245 ^@ Similarity ^@ Belongs to the APC1 family. http://togogenome.org/gene/9541:MPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSK7 ^@ Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||stereocilium http://togogenome.org/gene/9541:CD37 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5D2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:TRIM54 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLK1 ^@ Function|||Subcellular Location Annotation ^@ May bind and stabilize microtubules during myotubes formation.|||Z line http://togogenome.org/gene/9541:LXN ^@ http://purl.uniprot.org/uniprot/A0A2K5WLX9 ^@ Similarity ^@ Belongs to the protease inhibitor I47 (latexin) family. http://togogenome.org/gene/9541:TNFSF10 ^@ http://purl.uniprot.org/uniprot/I7GIW0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9541:CBX2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZ26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RBBP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ72 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:BRCC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU36 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/9541:RRM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSY5 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/9541:TULP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U007|||http://purl.uniprot.org/uniprot/A0A2K5U043 ^@ Similarity ^@ Belongs to the TUB family. http://togogenome.org/gene/9541:LOC101867505 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3W6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm http://togogenome.org/gene/9541:SERPINA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSY1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:INTS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIL5 ^@ Similarity ^@ Belongs to the Integrator subunit 3 family. http://togogenome.org/gene/9541:RPL13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UL98 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/9541:ING3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMH5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9541:TMEM138 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ93|||http://purl.uniprot.org/uniprot/G7PPY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/9541:NPY5R ^@ http://purl.uniprot.org/uniprot/G8F2E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. http://togogenome.org/gene/9541:GRIA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLX4|||http://purl.uniprot.org/uniprot/A0A2K5TLY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMZ2 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9541:KCNB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X219 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon|||dendrite http://togogenome.org/gene/9541:EML1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFJ1 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/9541:SPATA18 ^@ http://purl.uniprot.org/uniprot/Q95K37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MIEAP family.|||Cytoplasm|||Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain).|||Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).|||Mitochondrion outer membrane http://togogenome.org/gene/9541:LOC102115394 ^@ http://purl.uniprot.org/uniprot/A0A7N9CNV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJX0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ACO2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0G3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/9541:FOXJ3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHE4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102124180 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHN0|||http://purl.uniprot.org/uniprot/G7Q335 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DCLK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVN1|||http://purl.uniprot.org/uniprot/A0A2K5TVQ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/Q4R4T5 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cell membrane|||Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.|||Cytoplasm|||Dynein axonemal particle|||ISGylated.|||In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.|||Melanosome|||Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.|||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10.|||Monomer. Homodimer (By similarity). Forms a complex with CDK6 and CDC37. Interacts with UNC45A; binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer (By similarity). Interacts with CHORDC1 (By similarity). Interacts with DNAJC7. Interacts with FKBP4. May interact with NWD1. Interacts with SGTA. Interacts with HSF1 in an ATP-dependent manner. Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2. Interacts with STUB1 and SMAD3. Interacts with XPO1 and AHSA1. Interacts with BIRC2. Interacts with KCNQ4; promotes cell surface expression of KCNQ4. Interacts with BIRC2; prevents auto-ubiquitination and degradation of its client protein BIRC2. Interacts with NOS3. Interacts with AHR; interaction is inhibited by HSP90AB1 phosphorylation on Ser-226 and Ser-255. Interacts with STIP1 and CDC37; upon SMYD2-dependent methylation. Interacts with JAK2 and PRKCE; promotes functional activation in a heat shock-dependent manner. Interacts with HSP90AA1; interaction is constitutive. HSP90AB1-CDC37 chaperone complex interacts with inactive MAPK7 (via N-terminal half) in resting cells; the interaction is MAP2K5-independent and prevents from ubiquitination and proteasomal degradation. Interacts with CDC25A; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression. Interacts with TP53 (via DNA binding domain); suppresses TP53 aggregation and prevents from irreversible thermal inactivation. Interacts with TGFB1 processed form (LAP); inhibits latent TGFB1 activation (By similarity). Interacts with TRIM8; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1 (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with PDCL3 (By similarity). Interacts with TTC4 (via TPR repeats) (By similarity). Interacts with IL1B; the interaction facilitates cargo translocation into the ERGIC (By similarity).|||Nucleus|||Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide. Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.|||S-nitrosylated; negatively regulates the ATPase activity.|||Secreted|||The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.|||Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro). http://togogenome.org/gene/9541:H1-5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:PGM2L1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAA4 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/9541:PRKG2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ94|||http://purl.uniprot.org/uniprot/G7P527 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/9541:OTOP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CAV1 ^@ http://purl.uniprot.org/uniprot/I7GJT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/9541:PRDM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1G2|||http://purl.uniprot.org/uniprot/A0A2K5U1I4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PNOC ^@ http://purl.uniprot.org/uniprot/A0A2K5VPQ6|||http://purl.uniprot.org/uniprot/G7PCZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Secreted http://togogenome.org/gene/9541:MITF ^@ http://purl.uniprot.org/uniprot/A0A2K5WMF9|||http://purl.uniprot.org/uniprot/G7NZ88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9541:MPV17L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/9541:LOC101925699 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A7N9IA00|||http://purl.uniprot.org/uniprot/A0A8J8YJA8|||http://purl.uniprot.org/uniprot/G7Q1J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/9541:APOA2 ^@ http://purl.uniprot.org/uniprot/G7NXA8|||http://purl.uniprot.org/uniprot/P18656 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the apolipoprotein A2 family.|||May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.|||Monomer. Interacts with NAXE and NDRG1 (By similarity).|||Plasma.|||Secreted http://togogenome.org/gene/9541:BPGM ^@ http://purl.uniprot.org/uniprot/Q4R6L7 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ At alkaline pH BPGM favors the synthase reaction; however, at lower pH the phosphatase reaction is dominant. Inhibited by citrate.|||Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Homodimer.|||Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. http://togogenome.org/gene/9541:GUCA2A ^@ http://purl.uniprot.org/uniprot/A0A2K5UVW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9541:COG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V650 ^@ Function|||Similarity ^@ Belongs to the COG3 family.|||Involved in ER-Golgi transport. http://togogenome.org/gene/9541:CXCL10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:RPL24 ^@ http://purl.uniprot.org/uniprot/P61122 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm|||Mono-ADP-ribosylation at Glu-4 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation. http://togogenome.org/gene/9541:ADAM5 ^@ http://purl.uniprot.org/uniprot/Q28483 ^@ Caution|||Developmental Stage|||Function|||PTM|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Detected in elongate spermatids, and in caput and cauda epididymal spermatozoa (at protein level).|||Detected in testis (at protein level). Detected in adult and prepubertal testis. Detected at very low levels in heart, kidney, brain, muscle ovary and uterus.|||Interacts with TEX101.|||Membrane|||Not expected to have protease activity.|||Subject to proteolytic processing during epididymal transit of spermatozoa.|||This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). http://togogenome.org/gene/9541:PDE6C ^@ http://purl.uniprot.org/uniprot/A0A2K5TRP4|||http://purl.uniprot.org/uniprot/A0A8J8XK22 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:TRAPPC2B ^@ http://purl.uniprot.org/uniprot/I7G790 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/9541:ACSS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIE2|||http://purl.uniprot.org/uniprot/A0A7N9CN34 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:SCGN ^@ http://purl.uniprot.org/uniprot/A0A8J8YES1|||http://purl.uniprot.org/uniprot/G7P4K7 ^@ Subcellular Location Annotation ^@ secretory vesicle membrane http://togogenome.org/gene/9541:SLC7A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U070 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/9541:CHD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6M5 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.|||DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.|||Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Sumoylated. http://togogenome.org/gene/9541:LOC102118042 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC99|||http://purl.uniprot.org/uniprot/G7NZQ6 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/9541:POLD2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHG8|||http://purl.uniprot.org/uniprot/Q4R5Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Nucleus http://togogenome.org/gene/9541:RARS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQB1|||http://purl.uniprot.org/uniprot/G7P3K3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:YWHAQ ^@ http://purl.uniprot.org/uniprot/A0A7N9DCE6 ^@ Function|||Similarity ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|||Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:GABRQ ^@ http://purl.uniprot.org/uniprot/A0A2K5WU49 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:RSPO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTQ7 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9541:PARP12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHU5 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:B9D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKM2 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9541:CSF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GM-CSF family.|||Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.|||Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.|||Secreted http://togogenome.org/gene/9541:MANBAL ^@ http://purl.uniprot.org/uniprot/A0A8J8XIZ4|||http://purl.uniprot.org/uniprot/G7PGF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/9541:SELENOS ^@ http://purl.uniprot.org/uniprot/A0A2K5U765 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein S family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.|||Membrane http://togogenome.org/gene/9541:FAXC ^@ http://purl.uniprot.org/uniprot/A0A2K5WWM2 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/9541:NCR3 ^@ http://purl.uniprot.org/uniprot/P61483 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natural cytotoxicity receptor (NCR) family.|||Cell membrane|||Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation.|||Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6. http://togogenome.org/gene/9541:SPR ^@ http://purl.uniprot.org/uniprot/A0A8J8YLX2|||http://purl.uniprot.org/uniprot/G7PMG9 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/9541:SLC25A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6E8|||http://purl.uniprot.org/uniprot/I7G9S2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:FLCN ^@ http://purl.uniprot.org/uniprot/A0A7N9DCK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/9541:CDK6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XB64|||http://purl.uniprot.org/uniprot/G7P1D7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:SGCG ^@ http://purl.uniprot.org/uniprot/A0A2K5W3M6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9541:PLRG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWH6 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/9541:RSPH3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMF0|||http://purl.uniprot.org/uniprot/Q4R672 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flagellar radial spoke RSP3 family.|||flagellum axoneme http://togogenome.org/gene/9541:CTNNBL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1L3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:BMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V439 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/9541:ELF5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0W6|||http://purl.uniprot.org/uniprot/G7PQE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:PRR5L ^@ http://purl.uniprot.org/uniprot/A0A7N9DDG5 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/9541:GPR34 ^@ http://purl.uniprot.org/uniprot/Q2ACI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Orphan receptor. http://togogenome.org/gene/9541:TRAF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9541:OTX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL55|||http://purl.uniprot.org/uniprot/G7PAC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9541:SLC16A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GLRX ^@ http://purl.uniprot.org/uniprot/Q25N99 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/9541:ACTR10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFH8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:RTN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0A3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102132662 ^@ http://purl.uniprot.org/uniprot/F8RBU3 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9541:KXD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/9541:ALG5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEI8|||http://purl.uniprot.org/uniprot/G7PW14 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/9541:MB ^@ http://purl.uniprot.org/uniprot/G7PFA9|||http://purl.uniprot.org/uniprot/P02150 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/9541:KCTD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KCTD3 family.|||Cell membrane http://togogenome.org/gene/9541:SLC26A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sodium-independent transporter of chloride and iodide. http://togogenome.org/gene/9541:CYP27B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTY3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:PPT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI68 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/9541:ERBB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9541:CUZD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5M7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SCN2A ^@ http://purl.uniprot.org/uniprot/A0A2K5TT06|||http://purl.uniprot.org/uniprot/A0A2K5TT46 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/9541:TM4SF18 ^@ http://purl.uniprot.org/uniprot/A0A7N9CA86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/9541:SEH1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UCH9|||http://purl.uniprot.org/uniprot/A0A7N9D3S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/9541:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ71|||http://purl.uniprot.org/uniprot/A0A2K5VZC3|||http://purl.uniprot.org/uniprot/A0A2K5VZD7 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with KCNJ11.|||Membrane http://togogenome.org/gene/9541:LOC102124095 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQY2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:THOC6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWH0|||http://purl.uniprot.org/uniprot/G7Q0B3 ^@ Similarity ^@ Belongs to the WD repeat THOC6 family. http://togogenome.org/gene/9541:GPKOW ^@ http://purl.uniprot.org/uniprot/A0A8J8XSZ1|||http://purl.uniprot.org/uniprot/G7Q2P7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MOS2 family.|||Nucleus|||RNA-binding protein involved in pre-mRNA splicing. http://togogenome.org/gene/9541:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CBN5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9541:PPP2R5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WHQ3 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9541:SGIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU08 ^@ Function|||Subcellular Location Annotation ^@ May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.|||clathrin-coated pit http://togogenome.org/gene/9541:FAM72A ^@ http://purl.uniprot.org/uniprot/A0A8J8XC11|||http://purl.uniprot.org/uniprot/G7NVB7 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/9541:PLPP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:RAB29 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/9541:IFITM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMX3 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:HBEGF ^@ http://purl.uniprot.org/uniprot/A0A2K5VHS5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:MFAP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XU30|||http://purl.uniprot.org/uniprot/Q4R7A1 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/9541:CCL25 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSD9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:REM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W106 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9541:TFDP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZQ7|||http://purl.uniprot.org/uniprot/A0A2K5WZQ9|||http://purl.uniprot.org/uniprot/A0A2K5WZR4|||http://purl.uniprot.org/uniprot/A0A7N9CWX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:PGC ^@ http://purl.uniprot.org/uniprot/A0A2K5U1R3|||http://purl.uniprot.org/uniprot/A0A8J8Y3M3|||http://purl.uniprot.org/uniprot/G7P3W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Secreted http://togogenome.org/gene/9541:POU4F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9541:LOC102139187 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.|||Secreted http://togogenome.org/gene/9541:KEG98_p11 ^@ http://purl.uniprot.org/uniprot/C3W4Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SUV39H2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW32|||http://purl.uniprot.org/uniprot/Q4R3E0 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).|||Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity).|||In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.|||Interacts with SMAD5. The large PER complex involved in the histone methylation is composed of at least PER2, CBX3, TRIM28, SUV39H1 and/or SUV39H2; CBX3 mediates the formation of the complex (By similarity).|||Nucleus|||Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation.|||centromere http://togogenome.org/gene/9541:BCL2L13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXX2 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9541:LYG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZA1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9541:EZH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0B8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MYO5A ^@ http://purl.uniprot.org/uniprot/A0A2K5W139|||http://purl.uniprot.org/uniprot/A0A2K5W143|||http://purl.uniprot.org/uniprot/A0A2K5W1G4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:CD55 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1V4|||http://purl.uniprot.org/uniprot/A0A2K5X1Z0|||http://purl.uniprot.org/uniprot/A0A7N9CFZ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PPP2CB ^@ http://purl.uniprot.org/uniprot/A0A2K5X5X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family.|||Cytoplasm http://togogenome.org/gene/9541:GPR87 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBA8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:SH2B3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CRG6 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/9541:CACNG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. http://togogenome.org/gene/9541:LOC102125235 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGG3 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/9541:ARRDC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXR4|||http://purl.uniprot.org/uniprot/A0A8J8YAC8 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:SIVA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBT5 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus|||Phosphorylated by ABL2/ARG in response to oxidative stress. http://togogenome.org/gene/9541:CUL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cullin family.|||Cytoplasm http://togogenome.org/gene/9541:GNPDA2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YT43|||http://purl.uniprot.org/uniprot/G7P5I3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/9541:SLC4A10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSS1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9541:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W012 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:C8B ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ42 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:FAAH2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRN5|||http://purl.uniprot.org/uniprot/G7Q2V7 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/9541:TFDP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/9541:CFL2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPP2|||http://purl.uniprot.org/uniprot/G7PA25 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/9541:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7W0 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/9541:MARK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X332|||http://purl.uniprot.org/uniprot/A0A2K5X387 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9541:IKBKE ^@ http://purl.uniprot.org/uniprot/A0A2K5W1S9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:CTPS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3G0 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/9541:JRKL ^@ http://purl.uniprot.org/uniprot/A0A8J8XV97|||http://purl.uniprot.org/uniprot/G7PNI8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ENO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9541:SLC2A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane http://togogenome.org/gene/9541:SPOUT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGR3 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/9541:SLC12A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGV2|||http://purl.uniprot.org/uniprot/A0A2K5UH02|||http://purl.uniprot.org/uniprot/A0A8J8Y5I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:PDE10A ^@ http://purl.uniprot.org/uniprot/A0A2K5WS86|||http://purl.uniprot.org/uniprot/A0A2K5WSA7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVV4|||http://purl.uniprot.org/uniprot/A0A2K5WW04|||http://purl.uniprot.org/uniprot/A0A8J8Y5J4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/9541:GALNT11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:CHRNA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:LOC102126587 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ91 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:NPPC ^@ http://purl.uniprot.org/uniprot/A0A2K5WT12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/9541:KPNA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMW1|||http://purl.uniprot.org/uniprot/A0A2K5TMX7|||http://purl.uniprot.org/uniprot/A0A7N9CCA9 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:KHDC4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYR8|||http://purl.uniprot.org/uniprot/G7NV70 ^@ Similarity ^@ Belongs to the KHDC4 family. http://togogenome.org/gene/9541:LOC102132235 ^@ http://purl.uniprot.org/uniprot/G7PVY6|||http://purl.uniprot.org/uniprot/Q2PG08 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Homotrimer. Interacts with LTC4S and ALOX5 (By similarity).|||Membrane|||Nucleus membrane|||Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity).|||The C-terminal part after residue 140 is mostly disordered. http://togogenome.org/gene/9541:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:UBE3A ^@ http://purl.uniprot.org/uniprot/A0A2K5TLG4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/9541:MAPK14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJV8|||http://purl.uniprot.org/uniprot/A0A2K5WJW8|||http://purl.uniprot.org/uniprot/A0A8J8Y992 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/9541:ABCB9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U078|||http://purl.uniprot.org/uniprot/G8F535 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CSTA ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6Z8|||http://purl.uniprot.org/uniprot/G7NXR6 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/9541:LOC102136728 ^@ http://purl.uniprot.org/uniprot/A0A2K5TN42 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9541:SNX11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAR5|||http://purl.uniprot.org/uniprot/G7PU67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/9541:LIN28B ^@ http://purl.uniprot.org/uniprot/A0A7N9ICV0 ^@ Similarity ^@ Belongs to the lin-28 family. http://togogenome.org/gene/9541:BCL2A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMD8 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9541:RPS27L ^@ http://purl.uniprot.org/uniprot/A0A2K5X425 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:PRL ^@ http://purl.uniprot.org/uniprot/G7P4J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/9541:RPL39L ^@ http://purl.uniprot.org/uniprot/A0A2K5UF67 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:GMPPA ^@ http://purl.uniprot.org/uniprot/A0A2K5VWY8|||http://purl.uniprot.org/uniprot/G7PK50 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9541:LOC102142787 ^@ http://purl.uniprot.org/uniprot/Q2PFP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9541:VDAC2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CYU8 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9541:CFAP45 ^@ http://purl.uniprot.org/uniprot/Q4R8K2 ^@ Similarity ^@ Belongs to the CFAP45 family. http://togogenome.org/gene/9541:PTPRT ^@ http://purl.uniprot.org/uniprot/A0A2K5U0K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/9541:TUBA1A ^@ http://purl.uniprot.org/uniprot/I7G2D1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:GPR141 ^@ http://purl.uniprot.org/uniprot/A0A7N9DDA8|||http://purl.uniprot.org/uniprot/A0A8J8XWZ1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V041|||http://purl.uniprot.org/uniprot/A0A2K5V083|||http://purl.uniprot.org/uniprot/A0A7N9CHI2 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/9541:FUZ ^@ http://purl.uniprot.org/uniprot/A0A2K5W9A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fuzzy family.|||cytoskeleton http://togogenome.org/gene/9541:PABIR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CUL9|||http://purl.uniprot.org/uniprot/A0A7N9D5Q1|||http://purl.uniprot.org/uniprot/G7Q1R0 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/9541:DPAGT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1S0|||http://purl.uniprot.org/uniprot/G7PPA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:MS4A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXS6 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:BCL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/9541:CPSF4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y521|||http://purl.uniprot.org/uniprot/G7P0A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/9541:OSTN ^@ http://purl.uniprot.org/uniprot/G7NYP9 ^@ Caution|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Osteocrin family.|||Expression is induced by neuronal activity in the developing cerebral cortex: expression is driven by the presence of a enhancer sequence only present in primates that binds the MEF2 transcription factors (PubMed:27830782).|||Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience. Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (By similarity). Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).|||Interacts with NPR3.|||Secreted|||This protein-coding gene has been repurposed in primates, with the presence of a new enhancer sequence that drives expression in brain in response to sensory experience, leading to restrict dendritic growth in the developing cortex (PubMed:27830782). http://togogenome.org/gene/9541:FZD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLJ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:HHATL ^@ http://purl.uniprot.org/uniprot/A0A8J8YIJ7|||http://purl.uniprot.org/uniprot/G7NY66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:METAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW41 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/9541:OXER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ10 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:MPP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||adherens junction|||tight junction http://togogenome.org/gene/9541:ZNF383 ^@ http://purl.uniprot.org/uniprot/Q4R6C2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Cytoplasm|||May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.|||Nucleus|||The KRAB domain is responsible for the transcriptional repressor activity. http://togogenome.org/gene/9541:LOC102146935 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHJ6 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:LOC102146005 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMQ0|||http://purl.uniprot.org/uniprot/Q4R5L7 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with EIF4G1. Associates with ribosomes.|||nucleoplasm http://togogenome.org/gene/9541:SLC37A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYE4|||http://purl.uniprot.org/uniprot/A0A2K5TYF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/9541:ZNF706 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS81 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PIM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2N0 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.|||Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. http://togogenome.org/gene/9541:CRISP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4E5 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:USP9X ^@ http://purl.uniprot.org/uniprot/A0A2K5V070 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9541:FAH ^@ http://purl.uniprot.org/uniprot/A0A2K5U3A1 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/9541:PTAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4L5|||http://purl.uniprot.org/uniprot/A0A2K5U4M3 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/9541:LOC102133057 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102116269 ^@ http://purl.uniprot.org/uniprot/A0A8J8YET7|||http://purl.uniprot.org/uniprot/G7PMI1 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9541:B3GALNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U945 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:DOCK11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X856 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/9541:ATP5PB ^@ http://purl.uniprot.org/uniprot/A0A2K5TRC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/9541:HACD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8W6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:SLC35F6 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2N0|||http://purl.uniprot.org/uniprot/G7PLU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLC35F solute transporter family.|||Interacts with SLC25A5.|||May play a role as a nucleotide-sugar transporter.|||Membrane|||Mitochondrion http://togogenome.org/gene/9541:SLC15A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V056 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/9541:WNT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZH3|||http://purl.uniprot.org/uniprot/G7PHR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:CEP43 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9541:LOC102133455 ^@ http://purl.uniprot.org/uniprot/A0A7N9CRV9 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:IMMP2L ^@ http://purl.uniprot.org/uniprot/A0A2K5X380 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ARFGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVR7 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9541:KITLG ^@ http://purl.uniprot.org/uniprot/A0A7N9CAX5|||http://purl.uniprot.org/uniprot/A0A7N9DG76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/9541:DOP1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V0M3|||http://purl.uniprot.org/uniprot/A0A2K5V0S2 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/9541:ITM2B ^@ http://purl.uniprot.org/uniprot/Q60HC1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ITM2 family.|||Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.|||Cell membrane|||Endosome membrane|||Glycosylation at Asn-170 is important for cell surface localization, but doesn't affect furin- and ADAM10-induced proteolytic processing.|||Golgi apparatus membrane|||Homodimer; disulfide-linked. Interacts with SPPL2A and SPPL2B. Interacts with APP. Mature BRI2 (mBRI2) interacts with the APP amyloid-beta A4 protein; the interaction occurs at the cell surface and in the endocytic compartments and enable alpha- and beta-secretase-induced APP cleavage inhibition. Mature BRI2 (mBRI2) interacts with the APP C99; the interaction occurs in the endocytic compartments and enable gamma-secretase-induced C99 cleavage inhibition. May form heterodimers with Bri23 peptide and APP amyloid-beta protein 40 (By similarity). Interacts with ADAM7 in sperm; the interaction increases following capacitation (By similarity).|||Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.|||Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity).|||Secreted|||The ectodomain C-terminal part of the imBRI2 is processed by furin producing a secreted Bri23 peptide and a mature BRI2, membrane form (mBRI2). The remaining part of the ectodomain of mBRI2 containing the BRICHOS domain is cleaved by ADAM10 and is secreted (BRI2C, soluble form). The membrane-bound N-terminal fragment (BRI2C, membrane form) is further proteolytically processed by SPPL2A and SPPL2B through regulated intramembrane proteolysis producing a secreted C-peptide and a BRI2 intracellular domain (BRI2 ICD) released in the cytosol. Shedding by ADAM10 facilitates intramembrane cleavage but is not absolutely required for BRI2 ICD generation (By similarity). http://togogenome.org/gene/9541:EXOSC7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTH2|||http://purl.uniprot.org/uniprot/G7NY47 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SMIM15 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQD8|||http://purl.uniprot.org/uniprot/G7P7K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/9541:LOC102125892 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1X0 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/9541:SPTLC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQA1 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:SLC39A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/9541:KCNJ3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:RPL23A ^@ http://purl.uniprot.org/uniprot/A0A2K5UIT1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9541:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1P6 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9541:LOC102138227 ^@ http://purl.uniprot.org/uniprot/M9ZR32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lambda interferon family.|||Secreted http://togogenome.org/gene/9541:SEMA3B ^@ http://purl.uniprot.org/uniprot/A0A2K5VF98 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LRRC8B ^@ http://purl.uniprot.org/uniprot/A0A2K5UKE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ABCB1 ^@ http://purl.uniprot.org/uniprot/Q8HZQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ADM ^@ http://purl.uniprot.org/uniprot/A0A2K5TTY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adrenomedullin family.|||Secreted http://togogenome.org/gene/9541:CXCR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP76|||http://purl.uniprot.org/uniprot/G8F5K4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/9541:CD53 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:TENT5C ^@ http://purl.uniprot.org/uniprot/A0A7N9D571|||http://purl.uniprot.org/uniprot/A0A8J8Y3K3 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/9541:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRZ8|||http://purl.uniprot.org/uniprot/A0A2K5TS08|||http://purl.uniprot.org/uniprot/A0A7N9I9D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/9541:PSME4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB62|||http://purl.uniprot.org/uniprot/A0A2K5WBG2 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/9541:PLPPR2 ^@ http://purl.uniprot.org/uniprot/G7PZE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:DCST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SOD2 ^@ http://purl.uniprot.org/uniprot/Q8HXP3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).|||Belongs to the iron/manganese superoxide dismutase family.|||Binds 1 Mn(2+) ion per subunit.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix|||Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.|||Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. http://togogenome.org/gene/9541:CUL4B ^@ http://purl.uniprot.org/uniprot/A0A2K5W089 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:LOC102141871 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CL43|||http://purl.uniprot.org/uniprot/A0A7N9CVN4 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/9541:RPS6KA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR69 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/9541:RAD1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/9541:PVALB ^@ http://purl.uniprot.org/uniprot/A0A2K5VH89 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/9541:LOC102141029 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG77 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9541:VSIG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULF2|||http://purl.uniprot.org/uniprot/A0A8J8YS04|||http://purl.uniprot.org/uniprot/G7Q3F3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HTR2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WA17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/9541:KCNK13 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPH6|||http://purl.uniprot.org/uniprot/G7PB58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:LOC101925710 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMW9|||http://purl.uniprot.org/uniprot/G7NZK0 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/9541:TIMM10 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0Z3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9541:UGT8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XN91|||http://purl.uniprot.org/uniprot/G7P652 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:IL10 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH31|||http://purl.uniprot.org/uniprot/G7NVB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/9541:PRIMPOL ^@ http://purl.uniprot.org/uniprot/A0A2K5X7L5 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/9541:CLEC16A ^@ http://purl.uniprot.org/uniprot/A0A2K5TX46 ^@ Similarity ^@ Belongs to the CLEC16A/gop-1 family. http://togogenome.org/gene/9541:FAM102B ^@ http://purl.uniprot.org/uniprot/A0A2K5X5M4|||http://purl.uniprot.org/uniprot/G8F4J1 ^@ Similarity ^@ Belongs to the EEIG family. http://togogenome.org/gene/9541:EIF4E ^@ http://purl.uniprot.org/uniprot/A0A2K5WU58|||http://purl.uniprot.org/uniprot/I7GAS4 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9541:ISL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC35B4 ^@ http://purl.uniprot.org/uniprot/Q95KB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for another nucleotide sugar. May couple UDP-alpha-D-glucuronate (UDP-GlcA) or UDP-alpha-D-xylose (UDP-Xyl) efflux to UDP-alpha-D-glucuronate (UDP-GlcA) influx into the ER lumen, which in turn stimulates glucuronidation and excretion of endobiotics and xenobiotics.|||Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:SPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the osteopontin family.|||Secreted http://togogenome.org/gene/9541:TRAF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W360 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/9541:CD47 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4H8|||http://purl.uniprot.org/uniprot/A0A2K5X523 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:CLU ^@ http://purl.uniprot.org/uniprot/A0A2K5VV75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clusterin family.|||Endoplasmic reticulum|||Membrane|||Microsome|||Mitochondrion membrane|||Nucleus|||Secreted|||chromaffin granule|||cytosol|||perinuclear region http://togogenome.org/gene/9541:LHX9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRT2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ACTR3B ^@ http://purl.uniprot.org/uniprot/A0A2K5WHL6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:CFTR ^@ http://purl.uniprot.org/uniprot/A0A2K5U4G6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|||Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.|||Membrane|||Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and NHERF1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through NHERF1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.|||Recycling endosome membrane http://togogenome.org/gene/9541:IL18 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ84|||http://purl.uniprot.org/uniprot/A0A2K5TJ87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Cytoplasm|||Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted http://togogenome.org/gene/9541:CSTF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIP5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FAM98A ^@ http://purl.uniprot.org/uniprot/A0A2K5UTV3 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/9541:SERP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/9541:SRP19 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPZ7|||http://purl.uniprot.org/uniprot/A0A7N9CAU8|||http://purl.uniprot.org/uniprot/G8F2L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP19 family.|||Cytoplasm http://togogenome.org/gene/9541:FABP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5TX64 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:ARHGEF7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W795|||http://purl.uniprot.org/uniprot/A0A2K5W7F8 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9541:BORCS8 ^@ http://purl.uniprot.org/uniprot/A0A2K5V483 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS8 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:LOC102131403 ^@ http://purl.uniprot.org/uniprot/A0A7N9CW39 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:GRK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYY3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9541:CYP26B1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IG73 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:GRK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TV47 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/9541:TSN ^@ http://purl.uniprot.org/uniprot/A0A2K5VL45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/9541:LOC102122319 ^@ http://purl.uniprot.org/uniprot/Q4W8A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Basolateral cell membrane|||Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Expressed (at protein level) in the kidney.|||Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient. Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:15846473). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:15846473) (By similarity). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (By similarity). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule. Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside. May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (PubMed:15846473) (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (By similarity). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (By similarity). http://togogenome.org/gene/9541:RHBDL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V670 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/9541:HGF ^@ http://purl.uniprot.org/uniprot/C9E9X6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. http://togogenome.org/gene/9541:CEP70 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLP6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.|||centrosome http://togogenome.org/gene/9541:HBE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIW1 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:IFI27 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/9541:GNAT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XU61|||http://purl.uniprot.org/uniprot/G7NXT3 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:TM9SF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJG6|||http://purl.uniprot.org/uniprot/G7P9Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9541:CDC45 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/9541:ING4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7V5|||http://purl.uniprot.org/uniprot/G8F3S4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9541:HNRNPR ^@ http://purl.uniprot.org/uniprot/A0A2K5WY29 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:AGTR1 ^@ http://purl.uniprot.org/uniprot/G7NZZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/9541:SCML2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/9541:PTAFR ^@ http://purl.uniprot.org/uniprot/A0A2K5UPJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane|||Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/9541:KCTD21 ^@ http://purl.uniprot.org/uniprot/A0A7N9CEL6|||http://purl.uniprot.org/uniprot/A0A8J8XEA7 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:IFNAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGY1|||http://purl.uniprot.org/uniprot/A0A7N9D7J0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II cytokine receptor family.|||Cell membrane|||Endosome|||Heterodimer with IFNAR2.|||Late endosome|||Lysosome|||Membrane|||Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. http://togogenome.org/gene/9541:EFNB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNA1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:MFAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR60 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:CDK9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDZ1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:LOC102128774 ^@ http://purl.uniprot.org/uniprot/G7P6U9|||http://purl.uniprot.org/uniprot/Q76KA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL32 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:SCRN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4I0 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9541:EBF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U465|||http://purl.uniprot.org/uniprot/A0A2K5U4D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9541:KPNA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXA0 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:SEPTIN11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXY1|||http://purl.uniprot.org/uniprot/A0A2K5VY70|||http://purl.uniprot.org/uniprot/A0A7N9D789 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:LOC102125690 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).|||Nucleus|||spindle pole http://togogenome.org/gene/9541:SGF29 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKH8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ATP5IF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQQ0|||http://purl.uniprot.org/uniprot/G7NWV6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase inhibitor family.|||Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.|||Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.|||Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.|||Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.|||Mitochondrion http://togogenome.org/gene/9541:LRRC8D ^@ http://purl.uniprot.org/uniprot/A0A7N9CFD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SRRD ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Y7 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/9541:DNAJA2 ^@ http://purl.uniprot.org/uniprot/I7GPI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TMEM14C ^@ http://purl.uniprot.org/uniprot/A0A2K5VEW3 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9541:CORO6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD52 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/9541:MUL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGR6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:EXOSC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U584 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:BMPR1B ^@ http://purl.uniprot.org/uniprot/A0A2K5W4R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:STC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7H0 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9541:FAM166A ^@ http://purl.uniprot.org/uniprot/A0A2K5U1M7 ^@ Similarity ^@ Belongs to the CIMIP2 family. http://togogenome.org/gene/9541:NPR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQF7|||http://purl.uniprot.org/uniprot/A0A2K5WQM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/9541:KRT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMJ9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:PRKCQ ^@ http://purl.uniprot.org/uniprot/A0A2K5WLP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/9541:CLRN3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJZ2|||http://purl.uniprot.org/uniprot/G7PEC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/9541:CNIH4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YII1|||http://purl.uniprot.org/uniprot/G7NTW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/9541:CRY2 ^@ http://purl.uniprot.org/uniprot/G7PQC1 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9541:PATL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ26|||http://purl.uniprot.org/uniprot/A0A2K5WQH7 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/9541:LRRC42 ^@ http://purl.uniprot.org/uniprot/A0A7N9IFT9 ^@ Similarity ^@ Belongs to the LRRC42 family. http://togogenome.org/gene/9541:S100A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRQ8 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:ATP6V1B1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XV71|||http://purl.uniprot.org/uniprot/G7PMF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/9541:UCP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLM4|||http://purl.uniprot.org/uniprot/G7PN78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:CZIB ^@ http://purl.uniprot.org/uniprot/A0A2K5U234 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/9541:NAA60 ^@ http://purl.uniprot.org/uniprot/I7GHY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA60 subfamily.|||Golgi apparatus membrane http://togogenome.org/gene/9541:RBM8A ^@ http://purl.uniprot.org/uniprot/A0A8J8YI94|||http://purl.uniprot.org/uniprot/G7NTP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/9541:SPDEF ^@ http://purl.uniprot.org/uniprot/A0A8J8XPV0|||http://purl.uniprot.org/uniprot/G7P2U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:BBS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5J4 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/9541:GGA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:SLC51A ^@ http://purl.uniprot.org/uniprot/A0A7N9DE93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:VAX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMN6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ZRANB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9B9|||http://purl.uniprot.org/uniprot/A0A2K5W9D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/9541:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBP1 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/9541:VMA21 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/9541:EOMES ^@ http://purl.uniprot.org/uniprot/A0A2K5TX18 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:DAD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJ59|||http://purl.uniprot.org/uniprot/G7P9T9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9541:PHETA2 ^@ http://purl.uniprot.org/uniprot/G7PFP6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sesquipedalian family.|||Early endosome|||Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/9541:LAMP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKF4|||http://purl.uniprot.org/uniprot/A0A8J8YC93|||http://purl.uniprot.org/uniprot/G7Q3L7|||http://purl.uniprot.org/uniprot/Q4R5B5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:NXT2 ^@ http://purl.uniprot.org/uniprot/I7GLF0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/9541:PIGH ^@ http://purl.uniprot.org/uniprot/A0A2K5TS98 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/9541:IMPDH2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y817|||http://purl.uniprot.org/uniprot/G7NXU9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/9541:MDM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM1 family.|||Nucleus|||centriole http://togogenome.org/gene/9541:BRIX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBZ9|||http://purl.uniprot.org/uniprot/G7P7C2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9541:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX81|||http://purl.uniprot.org/uniprot/A0A2K5WX93|||http://purl.uniprot.org/uniprot/A0A2K5WXT7 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9541:FNTB ^@ http://purl.uniprot.org/uniprot/A0A2K5WSQ5|||http://purl.uniprot.org/uniprot/A0A2K5WSS2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.|||Heterodimer of FNTA and FNTB. http://togogenome.org/gene/9541:CNOT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/9541:MBTPS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1G2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9541:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/A0A7N9D7C5|||http://purl.uniprot.org/uniprot/A0A8J8XE62|||http://purl.uniprot.org/uniprot/G7Q1T5 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/9541:PROM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VE89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/9541:POLR2G ^@ http://purl.uniprot.org/uniprot/A0A2K5U485 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9541:RPL34 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBG0|||http://purl.uniprot.org/uniprot/A0A2K5UH45 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/9541:PIGN ^@ http://purl.uniprot.org/uniprot/A0A2K5VN51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/9541:SGK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2R8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:NPC2 ^@ http://purl.uniprot.org/uniprot/P61918 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the NPC2 family.|||Binds cholesterol in a hydrophobic pocket; there are no hydrogen bonds between the sterol and the protein.|||Detected in epididymis.|||Endoplasmic reticulum|||Interacts with NPC1 (via the second lumenal domain) in a cholestrol-dependent manner. Interacts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking. Interacts with DHDDS. Interacts with NEDD4L (via C2 domain). Interacts with NPC1L1.|||Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).|||Lysosome|||Secreted http://togogenome.org/gene/9541:GPR183 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SMDT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLW1|||http://purl.uniprot.org/uniprot/G7PFP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102132704 ^@ http://purl.uniprot.org/uniprot/A0A7N9CS21 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:MANEA ^@ http://purl.uniprot.org/uniprot/A0A8J8YEI5|||http://purl.uniprot.org/uniprot/G7P424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:GNG11 ^@ http://purl.uniprot.org/uniprot/G7P1D1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:NSMCE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/9541:LOC102120590 ^@ http://purl.uniprot.org/uniprot/A0A2K5VX05 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9541:KRT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9Q7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:TAF12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVK9|||http://purl.uniprot.org/uniprot/A0A7N9DG10|||http://purl.uniprot.org/uniprot/G8F4R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/9541:PDSS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1G8 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/9541:TMED3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9541:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGF1|||http://purl.uniprot.org/uniprot/A0A7N9DEP1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:FOXP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC107126432 ^@ http://purl.uniprot.org/uniprot/A0A2K5USP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/9541:LOC102124577 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9541:ALDH1L1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFN1|||http://purl.uniprot.org/uniprot/G7NYF0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/9541:RRS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TP91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/9541:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVG7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:DAG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM36 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/9541:MRPL43 ^@ http://purl.uniprot.org/uniprot/A0A2K5W456 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/9541:POGLUT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVB9 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/9541:SEC23B ^@ http://purl.uniprot.org/uniprot/A0A8J8XJI6|||http://purl.uniprot.org/uniprot/Q9BE95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:MED22 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI95|||http://purl.uniprot.org/uniprot/G7PR93 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/9541:ATP6V1G2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V321 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:TPX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VME8|||http://purl.uniprot.org/uniprot/G7PGN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/9541:PCYOX1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WXH5 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9541:PCSK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5J1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/9541:GEM ^@ http://purl.uniprot.org/uniprot/A0A8J8YSC9|||http://purl.uniprot.org/uniprot/G7PC82 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/9541:NR1H4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYF5|||http://purl.uniprot.org/uniprot/A0A2K5TYG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:GCK ^@ http://purl.uniprot.org/uniprot/A0A2K5VIQ1 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/9541:KRT2 ^@ http://purl.uniprot.org/uniprot/G7PID3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:EMC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM52|||http://purl.uniprot.org/uniprot/A0A8J8YRR3|||http://purl.uniprot.org/uniprot/G7PAP1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CUTC ^@ http://purl.uniprot.org/uniprot/A0A8J8XRE7|||http://purl.uniprot.org/uniprot/G7PDQ4 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/9541:HEATR5B ^@ http://purl.uniprot.org/uniprot/A0A2K5V267|||http://purl.uniprot.org/uniprot/A0A8J8XGY1 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/9541:AMACR ^@ http://purl.uniprot.org/uniprot/A0A2K5V1A6 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/9541:GPR101 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDN8|||http://purl.uniprot.org/uniprot/G7Q1T8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:SPRYD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDH4|||http://purl.uniprot.org/uniprot/G7PII3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:BBOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJL2 ^@ Function|||Similarity ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine. http://togogenome.org/gene/9541:ADORA2A ^@ http://purl.uniprot.org/uniprot/G7PHD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/9541:BLMH ^@ http://purl.uniprot.org/uniprot/A0A2K5TUG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/9541:ESRRB ^@ http://purl.uniprot.org/uniprot/A0A7N9IF67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9541:TMEM63B ^@ http://purl.uniprot.org/uniprot/A0A7N9ICI8|||http://purl.uniprot.org/uniprot/A0A8J8YDD7|||http://purl.uniprot.org/uniprot/G7P403 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9541:PDCD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWN0 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/9541:ALKBH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAK3 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9541:TLCD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS27|||http://purl.uniprot.org/uniprot/G7NV14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:S1PR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UC89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:IFI35 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NMI family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9541:MRPL22 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTD7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9541:IL33 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family. Highly divergent.|||Chromosome|||Nucleus|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9541:NMD3 ^@ http://purl.uniprot.org/uniprot/A0A7N9DFA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SLC30A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W895 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9541:TRIQK ^@ http://purl.uniprot.org/uniprot/A0A2K5UNC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TMEM170B ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/9541:PRPSAP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCF7|||http://purl.uniprot.org/uniprot/A0A7N9IDC8 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/9541:DARS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7F9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/9541:UCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCT6 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/9541:UBXN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTT1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:MINDY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6J1 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/9541:UFM1 ^@ http://purl.uniprot.org/uniprot/Q4R4I2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UFM1 family.|||Cytoplasm|||Interacts with UBA5. Interacts with UFC1.|||Nucleus|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription. http://togogenome.org/gene/9541:EXOSC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9541:CSE1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WF48|||http://purl.uniprot.org/uniprot/A0A8J8YQ05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/9541:ST8SIA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:LOC102131547 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:KIF15 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily.|||spindle http://togogenome.org/gene/9541:ATP5F1C ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ24|||http://purl.uniprot.org/uniprot/A0A8J8YNN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9541:VEZT ^@ http://purl.uniprot.org/uniprot/A0A7N9CKC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/9541:SEC61B ^@ http://purl.uniprot.org/uniprot/A0A2K5TY58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/9541:KAT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8L4|||http://purl.uniprot.org/uniprot/A0A2K5U8P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/9541:LOC102144088 ^@ http://purl.uniprot.org/uniprot/A0A7N9CH16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Odorant receptor. http://togogenome.org/gene/9541:CEP20 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP43 family.|||centriole|||cilium basal body http://togogenome.org/gene/9541:VDAC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWZ7 ^@ Similarity ^@ Belongs to the eukaryotic mitochondrial porin family. http://togogenome.org/gene/9541:SNPH ^@ http://purl.uniprot.org/uniprot/A0A2K5V0S5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXD8 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:SERF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR10 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/9541:CLDND2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9541:ZEB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URR5 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/9541:PDS5B ^@ http://purl.uniprot.org/uniprot/A0A2K5WHF0|||http://purl.uniprot.org/uniprot/A0A2K5WHL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDS5 family.|||Nucleus http://togogenome.org/gene/9541:LOC102116507 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE54 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:YWHAZ ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Q2|||http://purl.uniprot.org/uniprot/G7PCF6 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:CNTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCR7|||http://purl.uniprot.org/uniprot/A0A2K5VCW8 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/9541:UNC5C ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ14|||http://purl.uniprot.org/uniprot/G7P5Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9541:RNMT ^@ http://purl.uniprot.org/uniprot/Q4R7K1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.|||Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. Interacts with RAMAC, this interaction significantly enhances RNA-binding and cap methyltransferase activity.|||Methyltransferase activity is activated by RAMAC.|||Nucleus http://togogenome.org/gene/9541:RPLP2 ^@ http://purl.uniprot.org/uniprot/I7GJM4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/9541:ARL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXT6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:ISY1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CWY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/9541:LIG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9541:HGD ^@ http://purl.uniprot.org/uniprot/A0A2K5VXD4 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/9541:LOC102144252 ^@ http://purl.uniprot.org/uniprot/A0A2K5W993|||http://purl.uniprot.org/uniprot/A0A2K5W9F1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:MTFR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9541:WNK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTA2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9541:TUBB ^@ http://purl.uniprot.org/uniprot/A0A2K5WBU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:NMNAT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKW6 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9541:PPFIA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXP8|||http://purl.uniprot.org/uniprot/A0A2K5UXX5 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9541:RAB14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WS33|||http://purl.uniprot.org/uniprot/A0A8J8XWB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/9541:CDKN1A ^@ http://purl.uniprot.org/uniprot/A0A8J8XAP2|||http://purl.uniprot.org/uniprot/G7P3C1 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9541:CAMK1G ^@ http://purl.uniprot.org/uniprot/A0A2K5U137 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:MED15 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNG5|||http://purl.uniprot.org/uniprot/A0A2K5TNH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 15 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:C14H11orf58 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVN6|||http://purl.uniprot.org/uniprot/A0A8J8YED3 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/9541:KEG98_p03 ^@ http://purl.uniprot.org/uniprot/C3W4Z5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 5 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DPEP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8R4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/9541:COG8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U545 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG8 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:CNR2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAP5|||http://purl.uniprot.org/uniprot/G7NVV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PLPPR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:NEIL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0A2 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/9541:NR2C1 ^@ http://purl.uniprot.org/uniprot/G8F430|||http://purl.uniprot.org/uniprot/Q95K90 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C2 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain). Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression (By similarity).|||Nucleus|||Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity).|||PML body|||Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-220, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity).|||Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity). http://togogenome.org/gene/9541:BAZ1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VE62 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SERPINH1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CCH8 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/9541:WNT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZG3|||http://purl.uniprot.org/uniprot/G7P2I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:GMPPB ^@ http://purl.uniprot.org/uniprot/A0A2K5UBH2|||http://purl.uniprot.org/uniprot/G8F4N3 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/9541:ATR ^@ http://purl.uniprot.org/uniprot/A0A2K5U8D7|||http://purl.uniprot.org/uniprot/A0A7N9D8L4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily. http://togogenome.org/gene/9541:CORO1A ^@ http://purl.uniprot.org/uniprot/A0A2K5URY2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat coronin family.|||Binds actin.|||Membrane|||cell cortex|||cytoskeleton|||phagosome membrane http://togogenome.org/gene/9541:RUNDC3B ^@ http://purl.uniprot.org/uniprot/A0A2K5TXD1|||http://purl.uniprot.org/uniprot/A0A7N9CLF4|||http://purl.uniprot.org/uniprot/A0A8J8Y7Q4 ^@ Similarity|||Subunit ^@ Belongs to the RUNDC3 family.|||Interacts with RAP2A. http://togogenome.org/gene/9541:MMP7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XW62|||http://purl.uniprot.org/uniprot/G7PNJ9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9541:GRM4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGS8|||http://purl.uniprot.org/uniprot/A0A2K5VGV9|||http://purl.uniprot.org/uniprot/A0A2K5VGY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NUDT5 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQS9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/9541:PDE6A ^@ http://purl.uniprot.org/uniprot/A0A2K5X2J2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:FAM3D ^@ http://purl.uniprot.org/uniprot/A0A7N9CBG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9541:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLT6|||http://purl.uniprot.org/uniprot/A0A2K5VLU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLC13A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2D1|||http://purl.uniprot.org/uniprot/G7P0J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9541:ALG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Belongs to the glycosyltransferase 58 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LONP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNH6|||http://purl.uniprot.org/uniprot/G7Q128 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.|||Belongs to the peptidase S16 family.|||Interacts with PEX5. Interacts with TYSND1.|||Peroxisome matrix http://togogenome.org/gene/9541:NDUFB7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:POLR3D ^@ http://purl.uniprot.org/uniprot/A0A2K5UM89 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TRIM36 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUQ5|||http://purl.uniprot.org/uniprot/A0A7N9DBA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:RXFP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSE7|||http://purl.uniprot.org/uniprot/A0A2K5VSF6|||http://purl.uniprot.org/uniprot/A0A8J8XFC7 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A2K5W6Y9|||http://purl.uniprot.org/uniprot/A0A2K5W705|||http://purl.uniprot.org/uniprot/A0A2K5W740|||http://purl.uniprot.org/uniprot/A0A8J8YAI2|||http://purl.uniprot.org/uniprot/G7NZ25 ^@ Similarity ^@ Belongs to the peroxisomal targeting signal receptor family. http://togogenome.org/gene/9541:TRIP12 ^@ http://purl.uniprot.org/uniprot/A0A2K5W101|||http://purl.uniprot.org/uniprot/A0A7N9CWS4|||http://purl.uniprot.org/uniprot/G7PK88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||nucleoplasm http://togogenome.org/gene/9541:WARS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZ21|||http://purl.uniprot.org/uniprot/G7PBM3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/9541:CAMK2A ^@ http://purl.uniprot.org/uniprot/A0A2K5VDJ3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:GRPEL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/9541:CASC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASC3 family.|||Nucleus speckle|||dendrite|||perinuclear region http://togogenome.org/gene/9541:FGF14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQR6|||http://purl.uniprot.org/uniprot/A0A7N9CAT2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:BCL7B ^@ http://purl.uniprot.org/uniprot/A0A2K5WN28 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9541:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3L0|||http://purl.uniprot.org/uniprot/A0A2K5V3Q6|||http://purl.uniprot.org/uniprot/G8F3Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIN1 family.|||Cytoplasmic vesicle http://togogenome.org/gene/9541:LOC102142266 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGR2 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/9541:RPL29 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPR9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/9541:CHDH ^@ http://purl.uniprot.org/uniprot/A0A2K5U1B5 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/9541:P4HA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5USE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/9541:TPRKB ^@ http://purl.uniprot.org/uniprot/A0A2K5VHW0 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/9541:ELMO1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CBV5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9541:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVJ1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:PRKAB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0G4 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/9541:CD63 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Cell surface|||Endosome membrane|||Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.|||Late endosome membrane|||Lysosome membrane|||Melanosome|||Membrane|||extracellular exosome|||multivesicular body http://togogenome.org/gene/9541:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIV1|||http://purl.uniprot.org/uniprot/G7PKK5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:KEG98_p02 ^@ http://purl.uniprot.org/uniprot/C3W4Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:AIDA ^@ http://purl.uniprot.org/uniprot/A0A7N9CRW4 ^@ Similarity ^@ Belongs to the AIDA family. http://togogenome.org/gene/9541:LPAR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102134263 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDT1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL28 family. http://togogenome.org/gene/9541:MDM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:MIGA1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CBP6 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/9541:PARG ^@ http://purl.uniprot.org/uniprot/A0A2K5VGN9 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/9541:PSMB2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DA15|||http://purl.uniprot.org/uniprot/A0A8J8XJ00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TNFSF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2X5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/9541:FGF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9Z0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:LOC102114868 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5C2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:NFX1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CVF7 ^@ Similarity ^@ Belongs to the NFX1 family. http://togogenome.org/gene/9541:TBX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPI4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:ST7 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULV5|||http://purl.uniprot.org/uniprot/Q2PG42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/9541:EHD4 ^@ http://purl.uniprot.org/uniprot/A0A7N9DAY1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/9541:ATP5PD ^@ http://purl.uniprot.org/uniprot/A0A2K5U1U7|||http://purl.uniprot.org/uniprot/A0A2K5U1V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ZKSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPZ5 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:CMTM8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SPSB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8G1|||http://purl.uniprot.org/uniprot/G7NTE0 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/9541:CCT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/9541:EFTUD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W206 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MRPL17 ^@ http://purl.uniprot.org/uniprot/A0A7N9CCT5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/9541:B3GAT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:NTAQ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NTAQ1 family.|||Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.|||Monomer. http://togogenome.org/gene/9541:ELK1 ^@ http://purl.uniprot.org/uniprot/I7G4D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:SV2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:PDIA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKB0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Part of a large chaperone multiprotein complex. http://togogenome.org/gene/9541:ST6GALNAC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:MPPED2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKL0|||http://purl.uniprot.org/uniprot/G7PQH5 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/9541:SMUG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.|||Nucleus http://togogenome.org/gene/9541:CDKN1B ^@ http://purl.uniprot.org/uniprot/A0A2K5V146|||http://purl.uniprot.org/uniprot/G7PJW2 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/9541:ZSCAN25 ^@ http://purl.uniprot.org/uniprot/A0A7N9IAK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ASB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDT3 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:LHX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM87|||http://purl.uniprot.org/uniprot/A0A2K5VMC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ATP9B ^@ http://purl.uniprot.org/uniprot/A0A2K5VBZ6|||http://purl.uniprot.org/uniprot/A0A2K5VC06|||http://purl.uniprot.org/uniprot/A0A7N9CZH0|||http://purl.uniprot.org/uniprot/A0A7N9D7E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/9541:RAB27B ^@ http://purl.uniprot.org/uniprot/A0A8J8YNG2|||http://purl.uniprot.org/uniprot/G7PWU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9541:P2RX3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XY24|||http://purl.uniprot.org/uniprot/G7PQ42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9541:DGAT2L6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0C2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:OPTN ^@ http://purl.uniprot.org/uniprot/Q95KA2 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle|||Golgi apparatus|||Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection.|||Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.|||Recycling endosome|||Self-associates (By similarity). Interacts with HD, GTF3A, TRAF3, TBK1 and MYO6. Interacts (via UBAN) with ubiquitinated TFRC. Interacts with active GTP-bound Rab8 (RAB8A and/or RAB8B). Interacts with TBC1D17. Binds to linear ubiquitin chains. Interacts with LC3 family members MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2; OPTN phosphorylation increases the association (at least with MAP1LC3B). Interacts with RAB12; the interaction may be indirect (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction does not lead to palmitoylation of OPTN (By similarity). Interacts with CYLD (By similarity). Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and OPTN (By similarity).|||The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.|||Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/9541:LOC101866861 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/9541:TMEM184C ^@ http://purl.uniprot.org/uniprot/A0A2K5U2Y7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:EIF2S2 ^@ http://purl.uniprot.org/uniprot/Q4R5G5 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/9541:FAM118B ^@ http://purl.uniprot.org/uniprot/A0A7N9CHQ2|||http://purl.uniprot.org/uniprot/A0A805R453 ^@ Similarity ^@ Belongs to the FAM118 family. http://togogenome.org/gene/9541:DEFB128 ^@ http://purl.uniprot.org/uniprot/A4H255 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:USP39 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUF9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FAM167B ^@ http://purl.uniprot.org/uniprot/A0A2K5TR07 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/9541:XPO6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CLP1 ^@ http://purl.uniprot.org/uniprot/G7PQ31|||http://purl.uniprot.org/uniprot/Q4R7R3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity). http://togogenome.org/gene/9541:SUSD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGW4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RIC3 ^@ http://purl.uniprot.org/uniprot/G7PQS9 ^@ Similarity ^@ Belongs to the ric-3 family. http://togogenome.org/gene/9541:YIPF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMJ1|||http://purl.uniprot.org/uniprot/A0A8J8YRQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Golgi apparatus membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:GAREM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4S9 ^@ Similarity ^@ Belongs to the GAREM family. http://togogenome.org/gene/9541:CLCN6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8D9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:MAP2K3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJP6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:GJB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFL8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:MTIF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR16 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/9541:CGA ^@ http://purl.uniprot.org/uniprot/G7P3J5|||http://purl.uniprot.org/uniprot/Q9BEH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin.|||Secreted|||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. http://togogenome.org/gene/9541:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:THYN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X461 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/9541:HOXD10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/9541:LOC102130773 ^@ http://purl.uniprot.org/uniprot/A0A8J8YM65|||http://purl.uniprot.org/uniprot/G7PZT7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/9541:OTX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YA87|||http://purl.uniprot.org/uniprot/G7PMB0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DDB2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDL2|||http://purl.uniprot.org/uniprot/G7PQA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/9541:PSMB10 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQ77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ARPC5L ^@ http://purl.uniprot.org/uniprot/A0A2K5V8A3 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/9541:LPAR3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRY6|||http://purl.uniprot.org/uniprot/G7NTK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:S1PR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TSPYL4 ^@ http://purl.uniprot.org/uniprot/Q9BDD7 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9541:CMBL ^@ http://purl.uniprot.org/uniprot/A0A8J8YI23|||http://purl.uniprot.org/uniprot/G7P784 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/9541:SLC18B1 ^@ http://purl.uniprot.org/uniprot/G7P347 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ZNF75A ^@ http://purl.uniprot.org/uniprot/G7Q0C4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:COL4A5 ^@ http://purl.uniprot.org/uniprot/A0A7N9D7T3 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/9541:LOC102139510 ^@ http://purl.uniprot.org/uniprot/A0A158SIQ0|||http://purl.uniprot.org/uniprot/Q8SPI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIII family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SRFBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUQ8 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/9541:MTURN ^@ http://purl.uniprot.org/uniprot/A0A7N9C985 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTURN family.|||Cytoplasm http://togogenome.org/gene/9541:SLAIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZE0 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9541:CYRIB ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ03|||http://purl.uniprot.org/uniprot/A0A2K5VZ07 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/9541:ATAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U312|||http://purl.uniprot.org/uniprot/A0A8J8XCG1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:ASPDH ^@ http://purl.uniprot.org/uniprot/A0A7N9C8S5 ^@ Similarity ^@ Belongs to the L-aspartate dehydrogenase family. http://togogenome.org/gene/9541:SERPINA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCH9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:ATP5F1E ^@ http://purl.uniprot.org/uniprot/A0A2K5UDE9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/9541:ACOT13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB63 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/9541:TPT1 ^@ http://purl.uniprot.org/uniprot/I7G286 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/9541:B9D2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y908|||http://purl.uniprot.org/uniprot/G7PXN5 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9541:LOC102123927 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAA9 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/9541:DDR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ56|||http://purl.uniprot.org/uniprot/A0A2K5VJE9|||http://purl.uniprot.org/uniprot/A0A7N9CTX2|||http://purl.uniprot.org/uniprot/A0A7N9CY37|||http://purl.uniprot.org/uniprot/G8F2H7 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/9541:KCNE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULE3 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/9541:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYE2 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9541:POLR3H ^@ http://purl.uniprot.org/uniprot/A0A8J8YFK6|||http://purl.uniprot.org/uniprot/G7PFN5|||http://purl.uniprot.org/uniprot/I7GKA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/9541:PRM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIC9|||http://purl.uniprot.org/uniprot/G7Q0H9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protamine P1 family.|||Chromosome|||Nucleus|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. http://togogenome.org/gene/9541:MS4A1 ^@ http://purl.uniprot.org/uniprot/M4ZHZ6 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:EXOG ^@ http://purl.uniprot.org/uniprot/A0A2K5U5P2 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/9541:CFB ^@ http://purl.uniprot.org/uniprot/A0A2K5TZY3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:ATP5PO ^@ http://purl.uniprot.org/uniprot/A0A7N9IET0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:HOXC12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FLOT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXI8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex.|||Membrane|||caveola http://togogenome.org/gene/9541:ORC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/9541:UTP23 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9E8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:NUF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YDP9|||http://purl.uniprot.org/uniprot/G7NU22 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/9541:SLC31A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZ70|||http://purl.uniprot.org/uniprot/G7PRM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/9541:APOM ^@ http://purl.uniprot.org/uniprot/G7P4P9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/9541:LOC102119500 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MECOM ^@ http://purl.uniprot.org/uniprot/A0A2K5V7G1|||http://purl.uniprot.org/uniprot/A0A7N9DAM4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PROKR1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIK3|||http://purl.uniprot.org/uniprot/G7PMD0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:CHRM4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XC81|||http://purl.uniprot.org/uniprot/G7PQB4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9541:STRADA ^@ http://purl.uniprot.org/uniprot/A0A2K5U873|||http://purl.uniprot.org/uniprot/A0A8J8YRS4 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9541:NEFL ^@ http://purl.uniprot.org/uniprot/A0A2K5UWG6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:ALG6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TAGLN3 ^@ http://purl.uniprot.org/uniprot/G8F2A6|||http://purl.uniprot.org/uniprot/Q4R5J4 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9541:ZNF280C ^@ http://purl.uniprot.org/uniprot/A0A2K5VYK8 ^@ Function|||Subcellular Location Annotation ^@ May function as a transcription factor.|||Nucleus http://togogenome.org/gene/9541:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYR3|||http://purl.uniprot.org/uniprot/A0A2K5UYS6|||http://purl.uniprot.org/uniprot/A0A2K5UYT7|||http://purl.uniprot.org/uniprot/A0A2K5UYV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||sarcolemma http://togogenome.org/gene/9541:SLC25A21 ^@ http://purl.uniprot.org/uniprot/A0A8J8YS57|||http://purl.uniprot.org/uniprot/G7PA42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:MCEE ^@ http://purl.uniprot.org/uniprot/A0A2K5WLL5 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/9541:TIGD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIV0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SYT14 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3H5 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9541:ACTG2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMV4|||http://purl.uniprot.org/uniprot/G7PMI2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:RBP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0J2|||http://purl.uniprot.org/uniprot/A0A8J8Y0E2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:PLPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URB3|||http://purl.uniprot.org/uniprot/A0A7N9IE10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:NUDT11 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4Y1|||http://purl.uniprot.org/uniprot/G8F3J0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DIPP subfamily. http://togogenome.org/gene/9541:PLCB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG05|||http://purl.uniprot.org/uniprot/A0A2K5VG07 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9541:PYCR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMQ2|||http://purl.uniprot.org/uniprot/A0A8J8YL72 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/9541:CAB39 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGX5|||http://purl.uniprot.org/uniprot/G7PK94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9541:SMG9 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1U7 ^@ Similarity ^@ Belongs to the SMG9 family. http://togogenome.org/gene/9541:NDUFA8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH60|||http://purl.uniprot.org/uniprot/G7PRI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHD3|||http://purl.uniprot.org/uniprot/A0A2K5UHD7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:TPR ^@ http://purl.uniprot.org/uniprot/A0A2K5V4Q4 ^@ Similarity ^@ Belongs to the TPR family. http://togogenome.org/gene/9541:ERLIN1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBL7|||http://purl.uniprot.org/uniprot/G7PDQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/9541:LOC102137297 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 6c family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SH3YL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSP2|||http://purl.uniprot.org/uniprot/A0A7N9D3Y5 ^@ Similarity|||Subunit ^@ Belongs to the SH3YL1 family.|||Interacts with SH3D19. http://togogenome.org/gene/9541:FABP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1P3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.|||Cytoplasm|||Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. http://togogenome.org/gene/9541:LSM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W897 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/9541:XKRX ^@ http://purl.uniprot.org/uniprot/G7Q383 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9541:PUS10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8M0 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/9541:FZD3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XUY6|||http://purl.uniprot.org/uniprot/G7PCZ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:OCLN ^@ http://purl.uniprot.org/uniprot/A0A8J8XBB2|||http://purl.uniprot.org/uniprot/G7P7N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/9541:SUSD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7L9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TMTC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9541:PAPSS1 ^@ http://purl.uniprot.org/uniprot/G7P619 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/9541:HNRNPA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAW3|||http://purl.uniprot.org/uniprot/A0A7N9CZ09 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:KCND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZL1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9541:LOC102121924 ^@ http://purl.uniprot.org/uniprot/G7PQ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PROS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VES4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102145339 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPJ1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:PGAM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V242 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/9541:MOB1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WX83|||http://purl.uniprot.org/uniprot/A0A2K5WXH6 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:ZMYND10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the ZMYND10 family.|||Dynein axonemal particle|||Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.|||centriolar satellite http://togogenome.org/gene/9541:LOC102123539 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJQ8|||http://purl.uniprot.org/uniprot/G7P2D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PPTC7 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6U1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:LOC102136165 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:SYPL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IEZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:SND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL07|||http://purl.uniprot.org/uniprot/A0A8J8XDP7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/9541:WDFY1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRH3 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9541:SLC35B1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4I0|||http://purl.uniprot.org/uniprot/G7PU92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9541:PRUNE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0F8 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/9541:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYD8 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/9541:SEPHS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWZ1 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/9541:GTF2H1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V602 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/9541:IGF2BP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X518 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||P-body|||Stress granule http://togogenome.org/gene/9541:LOC102116763 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGQ3|||http://purl.uniprot.org/uniprot/G7Q2M1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/9541:ACER2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0D7|||http://purl.uniprot.org/uniprot/G7PSA1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LEF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6A5|||http://purl.uniprot.org/uniprot/A0A2K5W6D6|||http://purl.uniprot.org/uniprot/A0A2K5W6D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/9541:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A8J8YN27|||http://purl.uniprot.org/uniprot/G7NW13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9541:CRYBB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC17|||http://purl.uniprot.org/uniprot/G7PHE6 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:ONECUT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/9541:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTF2|||http://purl.uniprot.org/uniprot/G8F411 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/9541:UNC119B ^@ http://purl.uniprot.org/uniprot/A0A2K5X4B7 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/9541:RPL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/9541:LOC102146338 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBJ9|||http://purl.uniprot.org/uniprot/G8F324 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:XRN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3C7|||http://purl.uniprot.org/uniprot/A0A2K5V3D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm http://togogenome.org/gene/9541:PDK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:COPS7A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6V2|||http://purl.uniprot.org/uniprot/G7PJN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RPL37A ^@ http://purl.uniprot.org/uniprot/A0A7N9D9L4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9541:SGSM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2L3 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/9541:VXN ^@ http://purl.uniprot.org/uniprot/A0A8J8XEU3|||http://purl.uniprot.org/uniprot/G7PBY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vexin family.|||Cell membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:CAMKK2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZ65 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:GLB1L ^@ http://purl.uniprot.org/uniprot/G7PK43|||http://purl.uniprot.org/uniprot/Q95LV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 35 family.|||Probable glycosyl hydrolase.|||Secreted http://togogenome.org/gene/9541:NATD1 ^@ http://purl.uniprot.org/uniprot/A0A7N9C8E1 ^@ Similarity ^@ Belongs to the NATD1 family. http://togogenome.org/gene/9541:P2RY1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTW9|||http://purl.uniprot.org/uniprot/G7NZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:G6PC1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IAD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:LOC102144453 ^@ http://purl.uniprot.org/uniprot/A0A7N9IDK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HUS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6G8 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/9541:CACNB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VP04|||http://purl.uniprot.org/uniprot/A0A2K5VP40|||http://purl.uniprot.org/uniprot/A0A2K5VP41|||http://purl.uniprot.org/uniprot/A0A2K5VP77 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/9541:RBM17 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9A1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/9541:CLNS1A ^@ http://purl.uniprot.org/uniprot/A0A2K5VE65|||http://purl.uniprot.org/uniprot/G8F520 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/9541:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/I7GEW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9541:POLR1E ^@ http://purl.uniprot.org/uniprot/A0A2K5VTT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/9541:LOC102116561 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZP4|||http://purl.uniprot.org/uniprot/A0A7N9IEQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/9541:SLF2 ^@ http://purl.uniprot.org/uniprot/G7PDS0 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/9541:WASHC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGQ0|||http://purl.uniprot.org/uniprot/G7PJB6 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/9541:GOLPH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:CHUK ^@ http://purl.uniprot.org/uniprot/A0A8J8XNK4|||http://purl.uniprot.org/uniprot/G7PDQ9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CPNE4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX78|||http://purl.uniprot.org/uniprot/A0A2K5UX88 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:CAMK1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5C5|||http://purl.uniprot.org/uniprot/G7NYU8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGK2|||http://purl.uniprot.org/uniprot/A0A2K5VGK8|||http://purl.uniprot.org/uniprot/A0A7N9D559 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:KCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5USG8|||http://purl.uniprot.org/uniprot/A0A2K5USL3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:HOXB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U427 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HSDL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YE60|||http://purl.uniprot.org/uniprot/G7PZV5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:DDX47 ^@ http://purl.uniprot.org/uniprot/A0A2K5W149 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/9541:LOC102129503 ^@ http://purl.uniprot.org/uniprot/G7PCD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:SLC20A1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DB23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter. http://togogenome.org/gene/9541:DUT ^@ http://purl.uniprot.org/uniprot/A0A2K5U4P8|||http://purl.uniprot.org/uniprot/I7GP54 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/9541:TMEM244 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJK9|||http://purl.uniprot.org/uniprot/G7P367 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NDUFA2 ^@ http://purl.uniprot.org/uniprot/G7P1Q5|||http://purl.uniprot.org/uniprot/G7P8H1|||http://purl.uniprot.org/uniprot/Q4R5E2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:STK17A ^@ http://purl.uniprot.org/uniprot/A0A7N9CRA5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:CABYR ^@ http://purl.uniprot.org/uniprot/Q4R3X7 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with FSCB.|||May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity).|||Phosphorylated on tyrosine residues during in vitro capacitation. Dephosphorylation affects its ability to bind calcium (By similarity).|||cytoskeleton|||flagellum http://togogenome.org/gene/9541:MCOLN2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSJ3 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:CLCF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/9541:HPX ^@ http://purl.uniprot.org/uniprot/A0A2K5WVL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the hemopexin family.|||Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.|||Secreted http://togogenome.org/gene/9541:CCNA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIK0 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9541:BYSL ^@ http://purl.uniprot.org/uniprot/A0A2K5V744 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/9541:HSPA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMB6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/9541:NMNAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI95 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/9541:PRR15 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSC4|||http://purl.uniprot.org/uniprot/G7P0H8 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/9541:SRP72 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/9541:MS4A5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y424|||http://purl.uniprot.org/uniprot/G7PQ01 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:IL36B ^@ http://purl.uniprot.org/uniprot/Q4R3X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9541:MT2A ^@ http://purl.uniprot.org/uniprot/G7Q161|||http://purl.uniprot.org/uniprot/P68303 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.|||This metallothionein binds zinc. http://togogenome.org/gene/9541:AP3M2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DGA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/9541:PEX7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Peroxisome matrix|||cytosol http://togogenome.org/gene/9541:MED27 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJW3|||http://purl.uniprot.org/uniprot/G7PRA7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 27 family.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:TTC39B ^@ http://purl.uniprot.org/uniprot/A0A2K5TYU0 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/9541:SEC22B ^@ http://purl.uniprot.org/uniprot/A0A8J8XBA0|||http://purl.uniprot.org/uniprot/G7NX73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:LOC102138501 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQA7 ^@ Similarity ^@ Belongs to the GPRASP family. http://togogenome.org/gene/9541:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU67|||http://purl.uniprot.org/uniprot/A0A7N9CID8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:SFRP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXT6|||http://purl.uniprot.org/uniprot/A0A8J8YNF6 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102119730 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQP4|||http://purl.uniprot.org/uniprot/G7P2L5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:DDIT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7L1|||http://purl.uniprot.org/uniprot/A0A979HL08 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/9541:SLC19A3 ^@ http://purl.uniprot.org/uniprot/A0A7N9DDZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.|||Membrane http://togogenome.org/gene/9541:AIF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFL1|||http://purl.uniprot.org/uniprot/G7P4P6 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9541:MTMR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF31|||http://purl.uniprot.org/uniprot/A0A2K5WF62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:L3HYPDH ^@ http://purl.uniprot.org/uniprot/A0A7N9CWN8|||http://purl.uniprot.org/uniprot/A0A8J8XFF6|||http://purl.uniprot.org/uniprot/G7PAE6 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/9541:SMS ^@ http://purl.uniprot.org/uniprot/A0A2K5U1T0 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/9541:RAB33A ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ87|||http://purl.uniprot.org/uniprot/G7Q3N9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/9541:CNTFR ^@ http://purl.uniprot.org/uniprot/A0A2K5WIH9 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/9541:DRAM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:FZR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA62 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/9541:KIAA1191 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4M7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P33MONOX family.|||Cytoplasm|||Interacts with NELFB, NOL12 and PRNP.|||Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. http://togogenome.org/gene/9541:CHRNA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5C1|||http://purl.uniprot.org/uniprot/A0A7N9CER9|||http://purl.uniprot.org/uniprot/A0A8J8XE37|||http://purl.uniprot.org/uniprot/G7PLL5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/9541:LPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB78|||http://purl.uniprot.org/uniprot/A0A2K5VBA0 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/9541:GMFG ^@ http://purl.uniprot.org/uniprot/A0A2K5W3U4 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/9541:NGF ^@ http://purl.uniprot.org/uniprot/G7NX40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted http://togogenome.org/gene/9541:LGMN ^@ http://purl.uniprot.org/uniprot/A0A2K5VM53|||http://purl.uniprot.org/uniprot/A0A8J8Y362 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/9541:SLC35B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WK56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9541:ELOC ^@ http://purl.uniprot.org/uniprot/A0A2K5WLS2 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/9541:CWF19L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUK7|||http://purl.uniprot.org/uniprot/A0A2K5UUP3 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/9541:FGF9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCT6|||http://purl.uniprot.org/uniprot/G7PVU6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:SLC25A11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNM7|||http://purl.uniprot.org/uniprot/A0A8J8YAW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:ATP1B4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZW9|||http://purl.uniprot.org/uniprot/A0A8J8Y471 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9541:KCTD11 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD36 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ60 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:MRPL36 ^@ http://purl.uniprot.org/uniprot/G8F2L2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/9541:LOC101866265 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. http://togogenome.org/gene/9541:DYNLL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/9541:GPR55 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZW1|||http://purl.uniprot.org/uniprot/G7PK96 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:ZNF500 ^@ http://purl.uniprot.org/uniprot/A0A2K5V409 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SYN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0P4 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/9541:CDC5L ^@ http://purl.uniprot.org/uniprot/A0A8J8YB92|||http://purl.uniprot.org/uniprot/G7P4R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEF1 family.|||Nucleus http://togogenome.org/gene/9541:CDC73 ^@ http://purl.uniprot.org/uniprot/A0A8J8YD42|||http://purl.uniprot.org/uniprot/G7NXD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC73 family.|||Nucleus http://togogenome.org/gene/9541:LOC102133200 ^@ http://purl.uniprot.org/uniprot/A0A7N9CF85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:EPHA4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAZ2|||http://purl.uniprot.org/uniprot/G7PK59 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9541:ENTPD1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DGH8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:LOC102125891 ^@ http://purl.uniprot.org/uniprot/A0A2K5X524 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MGAT4A ^@ http://purl.uniprot.org/uniprot/G7PMT1|||http://purl.uniprot.org/uniprot/Q4R854 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity).|||Golgi apparatus membrane|||Inhibited by UDP.|||N-glycosylated.|||Secreted http://togogenome.org/gene/9541:GATC ^@ http://purl.uniprot.org/uniprot/A0A8J8XNI1|||http://purl.uniprot.org/uniprot/G7PJ44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/9541:C5H4orf47 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP96 family.|||centrosome http://togogenome.org/gene/9541:CYP27A1 ^@ http://purl.uniprot.org/uniprot/B8K1T2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:DLG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR55|||http://purl.uniprot.org/uniprot/A0A2K5TR64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Membrane http://togogenome.org/gene/9541:CHMP4B ^@ http://purl.uniprot.org/uniprot/A0A2K5WZD2 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:NUDT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Cytoplasm|||May contribute to the regulation of cell proliferation.|||Mitochondrion|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/9541:SESN1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XG88|||http://purl.uniprot.org/uniprot/Q4R6P7|||http://purl.uniprot.org/uniprot/Q4R7Y6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sestrin family.|||Cytoplasm|||Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.|||Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine. Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them. Interacts with KEAP1, RBX1 and SQSTM1; in the SQSTM1-dependent autophagic degradation of KEAP1. May interact with PRDX1.|||Nucleus|||The C-terminal domain mediates interaction with GATOR2 through which it regulates TORC1 signaling.|||The N-terminal domain may have an alkylhydroperoxide reductase activity. http://togogenome.org/gene/9541:CMPK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VB30 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/9541:VIRMA ^@ http://purl.uniprot.org/uniprot/A0A2K5VWG2 ^@ Similarity ^@ Belongs to the vir family. http://togogenome.org/gene/9541:DPYSL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCM5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9541:LOC102143773 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0I8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9541:LECT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3L4 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/9541:CARMIL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/9541:RPL15 ^@ http://purl.uniprot.org/uniprot/Q4R5B2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Component of the large ribosomal subunit. Interacts with IFIT1 (via TPR repeats 1-4).|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:CHST11 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIA6|||http://purl.uniprot.org/uniprot/G7PJD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:EPC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPI8|||http://purl.uniprot.org/uniprot/A0A2K5TPK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/9541:YEATS4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS80|||http://purl.uniprot.org/uniprot/G7PI06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MRPL23 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9541:HTR7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:EEF2K ^@ http://purl.uniprot.org/uniprot/A0A8J8XP58|||http://purl.uniprot.org/uniprot/G7Q0P5 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. Alpha-type protein kinase family.|||Monomer or homodimer.|||Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. http://togogenome.org/gene/9541:LOC101865434 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/9541:NUP205 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJA6 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/9541:KRTCAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WII0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KRTCAP2 family.|||Membrane http://togogenome.org/gene/9541:LOC102117030 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEL1|||http://purl.uniprot.org/uniprot/G7PQW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ISCA2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CFA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/9541:LOC101866469 ^@ http://purl.uniprot.org/uniprot/G7P578 ^@ Similarity ^@ Belongs to the MORF4 family-associated protein family. http://togogenome.org/gene/9541:LIPF ^@ http://purl.uniprot.org/uniprot/A0A2K5VBR3 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9541:CYP7A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBY6|||http://purl.uniprot.org/uniprot/G7PBW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:CCDC25 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAU4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC25 family.|||Cell membrane|||Endomembrane system|||Interacts (via cytoplasmic region) with ILK. http://togogenome.org/gene/9541:OS9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum lumen|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation. http://togogenome.org/gene/9541:ABCG8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/9541:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A7N9CTS0|||http://purl.uniprot.org/uniprot/A0A8J8YHL9|||http://purl.uniprot.org/uniprot/G7PGZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/9541:TUBB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:GNGT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U966 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:FRZB ^@ http://purl.uniprot.org/uniprot/A0A2K5V9H7 ^@ Caution|||Function|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/9541:EXTL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:KDELR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:LOC102123198 ^@ http://purl.uniprot.org/uniprot/Q28482 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RPA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIM7 ^@ Similarity ^@ Belongs to the replication factor A protein 2 family. http://togogenome.org/gene/9541:LOC102124147 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCV1|||http://purl.uniprot.org/uniprot/A0A7N9DFH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:LOC102145066 ^@ http://purl.uniprot.org/uniprot/G7PWP2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:SLC16A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTQ4|||http://purl.uniprot.org/uniprot/G7NW70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/9541:LOC101865393 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNH3|||http://purl.uniprot.org/uniprot/G7PU91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/9541:DUSP6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMF4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/9541:SENP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TUE6 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9541:GFOD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSS3|||http://purl.uniprot.org/uniprot/G7P4F9 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/9541:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVP5|||http://purl.uniprot.org/uniprot/A0A8J8XFW1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:ADPRS ^@ http://purl.uniprot.org/uniprot/A0A2K5WFG0 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/9541:FAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V668 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9541:UBE2L6 ^@ http://purl.uniprot.org/uniprot/A0A7N9DDL7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:GLCE ^@ http://purl.uniprot.org/uniprot/A0A8J8Y221|||http://purl.uniprot.org/uniprot/G7P900 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/9541:SEC22C ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5P5|||http://purl.uniprot.org/uniprot/G7NY71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9541:CREM ^@ http://purl.uniprot.org/uniprot/A0A2K5VKL3|||http://purl.uniprot.org/uniprot/A0A7N9DAB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CDNF ^@ http://purl.uniprot.org/uniprot/A0A8J8YCX8|||http://purl.uniprot.org/uniprot/G7PEE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/9541:ARPC1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WSY0 ^@ Function|||Similarity ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. http://togogenome.org/gene/9541:LOC102122868 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBE1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9541:SEC22A ^@ http://purl.uniprot.org/uniprot/G7NYD2|||http://purl.uniprot.org/uniprot/Q4R866 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/9541:NUBPL ^@ http://purl.uniprot.org/uniprot/A0A8J8XZC4|||http://purl.uniprot.org/uniprot/G7PA18 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/9541:CCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3T5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:ALG8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CFAP107 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNK1|||http://purl.uniprot.org/uniprot/G7NU70 ^@ Function|||Subcellular Location Annotation ^@ Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.|||cilium axoneme http://togogenome.org/gene/9541:EAF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT64 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/9541:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/A0A7N9CX54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/9541:LOC102121218 ^@ http://purl.uniprot.org/uniprot/A0A2K5U687 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:CTSE ^@ http://purl.uniprot.org/uniprot/A0A2K5UJB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Secreted http://togogenome.org/gene/9541:ATP1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SUV39H1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYE5|||http://purl.uniprot.org/uniprot/A0A7N9CQR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/9541:PHACTR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI24 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9541:LOC102131468 ^@ http://purl.uniprot.org/uniprot/A0A2K5TML4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/9541:LOC101925149 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/9541:MRE11 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3W9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/9541:LOC102139994 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY81 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/9541:ARRB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2V3 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:CXCL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:LOC102137787 ^@ http://purl.uniprot.org/uniprot/G7NW93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PHF5A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2R2|||http://purl.uniprot.org/uniprot/G7PFN3 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/9541:SIDT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6U2|||http://purl.uniprot.org/uniprot/G7PP16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/9541:SZRD1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZQ5 ^@ Similarity ^@ Belongs to the SZRD1 family. http://togogenome.org/gene/9541:RPL35A ^@ http://purl.uniprot.org/uniprot/G8F3S7|||http://purl.uniprot.org/uniprot/P61272 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL33 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.|||Cytoplasm http://togogenome.org/gene/9541:MORF4L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEY5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HAT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YED4|||http://purl.uniprot.org/uniprot/G7PKT8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/9541:ASB7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNA7|||http://purl.uniprot.org/uniprot/G7P9J5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:RND3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQU8|||http://purl.uniprot.org/uniprot/G7PKK2 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/9541:STOML2 ^@ http://purl.uniprot.org/uniprot/G7PS14 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9541:LOC107130570 ^@ http://purl.uniprot.org/uniprot/A0A7N9D7A9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:LOC102138425 ^@ http://purl.uniprot.org/uniprot/G8F3E6 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:DDX6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0J2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:LOC102121747 ^@ http://purl.uniprot.org/uniprot/G7PHX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102145420 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6B8|||http://purl.uniprot.org/uniprot/A0A8J8YFM8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:KCNJ11 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNU2|||http://purl.uniprot.org/uniprot/G7PQM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/9541:ACTN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSR0 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/9541:SLC41A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9541:NAA35 ^@ http://purl.uniprot.org/uniprot/G7PSM3|||http://purl.uniprot.org/uniprot/Q4R708 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.|||Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/9541:ACSL4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEM6|||http://purl.uniprot.org/uniprot/G7Q3G4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:USP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2D8 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/9541:GJB1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAQ4|||http://purl.uniprot.org/uniprot/G8F3U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:LOC107129591 ^@ http://purl.uniprot.org/uniprot/G7P2L6|||http://purl.uniprot.org/uniprot/G7P2P0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CCND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKJ8 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:CUL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2Z2|||http://purl.uniprot.org/uniprot/A0A2K5W2Z9 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:DOK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0K2 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9541:CCL8 ^@ http://purl.uniprot.org/uniprot/G7PU24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:LOC102117144 ^@ http://purl.uniprot.org/uniprot/G7P2Q3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:NT5C3A ^@ http://purl.uniprot.org/uniprot/A0A2K5WTY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9541:CYLD ^@ http://purl.uniprot.org/uniprot/A0A2K5VGV6|||http://purl.uniprot.org/uniprot/A0A7N9CUC3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/9541:PYM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7E5|||http://purl.uniprot.org/uniprot/A0A2K5W7I1 ^@ Similarity|||Subunit ^@ Belongs to the pym family.|||Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex. http://togogenome.org/gene/9541:RGR ^@ http://purl.uniprot.org/uniprot/A0A7N9CQU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RNF43 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZNRF3 family.|||Cell membrane http://togogenome.org/gene/9541:MACIR ^@ http://purl.uniprot.org/uniprot/A0A8J8YQW5|||http://purl.uniprot.org/uniprot/G7P810 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UNC119-binding protein family.|||Cytoplasm|||cilium http://togogenome.org/gene/9541:KCNH8 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBB6 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/9541:ACKR4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5K1|||http://purl.uniprot.org/uniprot/G7NXZ5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:ARMCX3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXV7|||http://purl.uniprot.org/uniprot/A0A8J8XM55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9541:FGD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL46|||http://purl.uniprot.org/uniprot/A0A2K5WL79 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:IRF5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PIP4P1 ^@ http://purl.uniprot.org/uniprot/Q4R6W2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity). May play a role in the regulation of cellular cholesterol metabolism (By similarity).|||Cell membrane|||Interacts (via transmembrane domain) with ATP6V0D1 (By similarity). Interacts with LAMTOR1, RRAGA and RRAGC (By similarity).|||Late endosome membrane|||Lysosome membrane|||phagosome membrane http://togogenome.org/gene/9541:EPS8L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUW4 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/9541:GGA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U969 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:ACADM ^@ http://purl.uniprot.org/uniprot/A0A2K5V3V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:SLC25A46 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSG9|||http://purl.uniprot.org/uniprot/Q4R3T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:TMEFF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWD7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FAM200A ^@ http://purl.uniprot.org/uniprot/Q4R6P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM200 family.|||Membrane http://togogenome.org/gene/9541:SLC25A38 ^@ http://purl.uniprot.org/uniprot/A0A7N9IC41|||http://purl.uniprot.org/uniprot/A0A8J8YS09|||http://purl.uniprot.org/uniprot/G7NYJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/9541:GPX8 ^@ http://purl.uniprot.org/uniprot/G7P7I5 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9541:MRPS24 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/9541:DDRGK1 ^@ http://purl.uniprot.org/uniprot/G7PGU8 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/9541:SLC5A11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CD28 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCD2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GALNT18 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:EIF3K ^@ http://purl.uniprot.org/uniprot/A0A2K5X240|||http://purl.uniprot.org/uniprot/G8F5R8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:HARBI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/9541:MRPL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAW8|||http://purl.uniprot.org/uniprot/A0A8J8XHY5|||http://purl.uniprot.org/uniprot/G7P3Z3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/9541:ACAP2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IDL1 ^@ Activity Regulation|||Domain|||Function|||Subcellular Location Annotation ^@ Endosome membrane|||GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.|||GTPase-activating protein for the ADP ribosylation factor family.|||PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.|||The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions. http://togogenome.org/gene/9541:TMEM176B ^@ http://purl.uniprot.org/uniprot/A0A2K5VMR3 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/9541:SGSM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ30|||http://purl.uniprot.org/uniprot/A0A7N9C9P6 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/9541:PRSS16 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDF6 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/9541:RAB39B ^@ http://purl.uniprot.org/uniprot/A0A8J8XD78|||http://purl.uniprot.org/uniprot/G7Q238 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7A9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:FUBP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6Y9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CAB39L ^@ http://purl.uniprot.org/uniprot/A0A8J8XN18|||http://purl.uniprot.org/uniprot/G7PVE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/9541:ABITRAM ^@ http://purl.uniprot.org/uniprot/A0A2K5W2H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/9541:PDE4D ^@ http://purl.uniprot.org/uniprot/A0A2K5VWF6|||http://purl.uniprot.org/uniprot/A0A2K5VWJ8|||http://purl.uniprot.org/uniprot/A0A2K5VWK7|||http://purl.uniprot.org/uniprot/A0A2K5VWK9|||http://purl.uniprot.org/uniprot/A0A2K5VWL9|||http://purl.uniprot.org/uniprot/A0A2K5VWR4|||http://purl.uniprot.org/uniprot/A0A7N9D392 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:DEFB123 ^@ http://purl.uniprot.org/uniprot/A0A8J8XK90|||http://purl.uniprot.org/uniprot/G7PGP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:RNF40 ^@ http://purl.uniprot.org/uniprot/A0A2K5V529 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9541:MMP13 ^@ http://purl.uniprot.org/uniprot/A0A2K5U988 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9541:NAPRT ^@ http://purl.uniprot.org/uniprot/A0A2K5X066 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/9541:LHX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PLOD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WMI3|||http://purl.uniprot.org/uniprot/A0A2K5WMZ3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/9541:UHRF2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DBW3|||http://purl.uniprot.org/uniprot/A0A7N9IGB3 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.|||Nucleus|||The YDG domain mediates the interaction with histone H3.|||The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3). http://togogenome.org/gene/9541:MTMR6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V469 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/9541:CCK ^@ http://purl.uniprot.org/uniprot/I7GJF3|||http://purl.uniprot.org/uniprot/P23362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gastrin/cholecystokinin family.|||Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.|||Secreted|||The precursor is cleaved by ACE, which removes the Gly-Arg-Arg peptide at the C-terminus, leading to mature hormone.|||The precursor is cleaved by proteases to produce a number of active cholecystokinins.|||This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. http://togogenome.org/gene/9541:GSKIP ^@ http://purl.uniprot.org/uniprot/A0A2K5X3U9 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/9541:PTPN1 ^@ http://purl.uniprot.org/uniprot/A0A7N9I9Q8 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/9541:EEF1D ^@ http://purl.uniprot.org/uniprot/A0A2K5WG05|||http://purl.uniprot.org/uniprot/A0A805R9Y0|||http://purl.uniprot.org/uniprot/Q4R3D4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma. Isoform 2 interacts with HSF1 and NFE2L2 (By similarity).|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.|||Nucleus|||Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). http://togogenome.org/gene/9541:TAFAZZIN ^@ http://purl.uniprot.org/uniprot/A0A2K5UMJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.|||Associates with multiple protein complexes.|||Belongs to the taffazin family.|||Mitochondrion inner membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:DPM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3B5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/9541:NT5E ^@ http://purl.uniprot.org/uniprot/A0A2K5V5U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-nucleotidase family.|||Membrane http://togogenome.org/gene/9541:SLC22A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SENP7 ^@ http://purl.uniprot.org/uniprot/A0A7N9CBT5|||http://purl.uniprot.org/uniprot/A0A7N9CR70|||http://purl.uniprot.org/uniprot/A0A7N9CWC6|||http://purl.uniprot.org/uniprot/A0A7N9D5A5|||http://purl.uniprot.org/uniprot/A0A7N9IGX0 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9541:TCL1B ^@ http://purl.uniprot.org/uniprot/G7PBF1 ^@ Similarity ^@ Belongs to the TCL1 family. http://togogenome.org/gene/9541:WNT10B ^@ http://purl.uniprot.org/uniprot/A0A2K5VIT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:HOXA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y696|||http://purl.uniprot.org/uniprot/G7P0P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9541:DNASE1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGN5|||http://purl.uniprot.org/uniprot/A0A7N9I9E6 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9541:CHRNG ^@ http://purl.uniprot.org/uniprot/A0A2K5TS72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:ZFP69B ^@ http://purl.uniprot.org/uniprot/A0A2K5VHX0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SLAIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6E7|||http://purl.uniprot.org/uniprot/A0A2K5W6F3 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/9541:GNPAT ^@ http://purl.uniprot.org/uniprot/A0A2K5V912 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/9541:TSEN15 ^@ http://purl.uniprot.org/uniprot/A0A2K5U572|||http://purl.uniprot.org/uniprot/A0A2K5U5A3 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/9541:IMMP1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:BAP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI92|||http://purl.uniprot.org/uniprot/G7NZW2 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9541:C7H15orf40 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2R8 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/9541:TM6SF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TM6SF family.|||Membrane http://togogenome.org/gene/9541:DCTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMV3|||http://purl.uniprot.org/uniprot/G7PMI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/9541:DTNA ^@ http://purl.uniprot.org/uniprot/A0A2K5UWT3|||http://purl.uniprot.org/uniprot/A0A2K5UX96|||http://purl.uniprot.org/uniprot/A0A2K5UXH1|||http://purl.uniprot.org/uniprot/A0A2K5UXM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/9541:URAD ^@ http://purl.uniprot.org/uniprot/A0A2K5VFU0 ^@ Function|||Similarity ^@ Belongs to the OHCU decarboxylase family.|||Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. http://togogenome.org/gene/9541:MARK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVC1|||http://purl.uniprot.org/uniprot/A0A2K5TVG8|||http://purl.uniprot.org/uniprot/A0A2K5TVI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/9541:KCNIP4 ^@ http://purl.uniprot.org/uniprot/Q8HYN7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the recoverin family.|||Cell membrane|||Component of heteromultimeric potassium channels (By similarity). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Interacts with KCND2 (By similarity). Interacts with KCND3 (By similarity). Interacts with the C-terminus of PSEN2 and probably PSEN1 (By similarity).|||Cytoplasm|||Peroxisome|||Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.|||The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current. http://togogenome.org/gene/9541:ELF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI97|||http://purl.uniprot.org/uniprot/G7PW33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:MZT2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WDI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MOZART2 family.|||centrosome|||spindle http://togogenome.org/gene/9541:STRADB ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ72 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. http://togogenome.org/gene/9541:TIMP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNU0 ^@ Similarity ^@ Belongs to the protease inhibitor I35 (TIMP) family. http://togogenome.org/gene/9541:PCOLCE ^@ http://purl.uniprot.org/uniprot/A0A2K5WMV4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:SDC2 ^@ http://purl.uniprot.org/uniprot/I7G7X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/9541:TRAF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/9541:ERCC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVW5|||http://purl.uniprot.org/uniprot/A0A2K5TVW7|||http://purl.uniprot.org/uniprot/A0A7N9IFE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/9541:YTHDF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U357 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9541:RPL35 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJW4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/9541:NDUFB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5USP8|||http://purl.uniprot.org/uniprot/G7PMD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TSPAN7 ^@ http://purl.uniprot.org/uniprot/Q4R5A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:YOD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQS7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin. http://togogenome.org/gene/9541:VPS26C ^@ http://purl.uniprot.org/uniprot/A0A2K5VWC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS26 family.|||Endosome http://togogenome.org/gene/9541:NDRG1 ^@ http://purl.uniprot.org/uniprot/A0A805QPH7|||http://purl.uniprot.org/uniprot/Q4R4Q3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDRG family.|||Cell membrane|||Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling ofCDH1. Interacts with APOA1, APOA2, PRA1 and RTN1 (By similarity).|||Nucleus|||Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity).|||Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent (By similarity).|||centrosome|||cytosol http://togogenome.org/gene/9541:PON1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQD9|||http://purl.uniprot.org/uniprot/G7P1C5 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit.|||Glycosylated. http://togogenome.org/gene/9541:CFAP418 ^@ http://purl.uniprot.org/uniprot/A0A2K5VME6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/9541:PPARD ^@ http://purl.uniprot.org/uniprot/A0A2K5W3V1|||http://purl.uniprot.org/uniprot/G7P2V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:CCL17 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:SPDL1 ^@ http://purl.uniprot.org/uniprot/Q4R7H3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Spindly family.|||Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect. Interacts with dynein intermediate chain and dynactin (DCTN1) (By similarity). Interacts with the catalytically active form of USP45 (By similarity).|||Monoubiquitinated with'Lys-48' linkage (By similarity). Deubiquitinated by USP45 (By similarity).|||Nucleus|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Plays a role in cell migration (By similarity).|||centrosome|||kinetochore|||spindle pole http://togogenome.org/gene/9541:KLC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQK2|||http://purl.uniprot.org/uniprot/A0A2K5UQN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9541:ATP1B2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X586 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9541:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DAR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9541:RAD18 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD18 family.|||Nucleus http://togogenome.org/gene/9541:STXBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGR0 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:GLYAT ^@ http://purl.uniprot.org/uniprot/A0A2K5UI23 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/9541:MRPL19 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ67 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/9541:LOC102122546 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRN2 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/9541:WNT8B ^@ http://purl.uniprot.org/uniprot/A0A2K5V9D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:FCER1G ^@ http://purl.uniprot.org/uniprot/Q8SPW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation.|||Belongs to the CD3Z/FCER1G family.|||Cell membrane|||IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Associates with FCGR1A; forms a functional signaling complex (By similarity). The signaling subunit of immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a heterodimer of CD247 and FCER1G, associates with the ligand binding subunit FCGR3A to form a functional receptor complex (By similarity). Associates with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK, enabling integrin-mediated activation of neutrophils and macrophages (By similarity). Interacts with CSF2RB and recruits SYK in response to IL3 stimulation; this interaction is direct (By similarity). Interacts with CD300LH; the interaction may be indirect. Interacts with CD300LD (By similarity). Interacts with TARM1 (By similarity). http://togogenome.org/gene/9541:DBX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3H5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:STAG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5USA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9541:NKAIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHB5|||http://purl.uniprot.org/uniprot/G7P387 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PTN ^@ http://purl.uniprot.org/uniprot/A0A2K5VRF2|||http://purl.uniprot.org/uniprot/A0A2K5VRP8 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/9541:NME9 ^@ http://purl.uniprot.org/uniprot/A0A2K5V278|||http://purl.uniprot.org/uniprot/A0A8J8XRC5|||http://purl.uniprot.org/uniprot/G7P034 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9541:MEOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CBLC ^@ http://purl.uniprot.org/uniprot/A0A2K5V7G2 ^@ Domain|||Function ^@ E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/9541:USP14 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7L4|||http://purl.uniprot.org/uniprot/A0A7N9CZD4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/9541:LOC102146459 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEU4|||http://purl.uniprot.org/uniprot/G7Q3I7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/9541:ARF1 ^@ http://purl.uniprot.org/uniprot/A0A158SIP9|||http://purl.uniprot.org/uniprot/Q4R5P2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Alternates between an inactive GDP-bound form and an active GTP-bound form. Intrinsic GTPase activity is almost undetectable in vitro. Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs).|||Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus|||Golgi apparatus membrane|||Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1. Interacts with C9orf72.|||Postsynaptic density|||Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity).|||synaptosome http://togogenome.org/gene/9541:SLC7A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9B8|||http://purl.uniprot.org/uniprot/A0A8J8YCV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RPL19 ^@ http://purl.uniprot.org/uniprot/G7NZM6|||http://purl.uniprot.org/uniprot/Q8HXN9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Citrullinated by PADI4.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.|||Cytoplasm http://togogenome.org/gene/9541:GPR83 ^@ http://purl.uniprot.org/uniprot/A0A7N9CN28 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:MAPRE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8Q4|||http://purl.uniprot.org/uniprot/A0A2K5X8R3|||http://purl.uniprot.org/uniprot/A0A2K5X8U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/9541:FOXB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFL3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EFS ^@ http://purl.uniprot.org/uniprot/A0A2K5TRI6|||http://purl.uniprot.org/uniprot/A0A7N9D1U2 ^@ Similarity ^@ Belongs to the CAS family. http://togogenome.org/gene/9541:ZHX2 ^@ http://purl.uniprot.org/uniprot/G7PCR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/9541:RMI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/9541:LOC102138137 ^@ http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:CNPY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDB9 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/9541:CTSZ ^@ http://purl.uniprot.org/uniprot/A0A2K5U716 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/9541:SLC39A7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y167|||http://purl.uniprot.org/uniprot/G7P2S2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LTA4H ^@ http://purl.uniprot.org/uniprot/A0A2K5U9C9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/9541:INSM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEF6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SCG5 ^@ http://purl.uniprot.org/uniprot/Q2PFP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.|||Belongs to the 7B2 family.|||Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.|||Secreted http://togogenome.org/gene/9541:RPTOR ^@ http://purl.uniprot.org/uniprot/A0A2K5TPP8 ^@ Similarity ^@ Belongs to the WD repeat RAPTOR family. http://togogenome.org/gene/9541:FUT10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/9541:SCAMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3C2|||http://purl.uniprot.org/uniprot/A0A2K5V3F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9541:ORC4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQ05|||http://purl.uniprot.org/uniprot/A0A8J8XCG5|||http://purl.uniprot.org/uniprot/G7PKJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/9541:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A2K5TX22|||http://purl.uniprot.org/uniprot/A0A7N9DGC9 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/9541:NAE1 ^@ http://purl.uniprot.org/uniprot/Q4R3L6 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity.|||Cell membrane|||Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2 (By similarity).|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity). The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development.|||Ubiquitinated by TRIP12, leading to its degradation by the proteasome. http://togogenome.org/gene/9541:IP6K1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSG4 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/9541:NPM3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAZ9|||http://purl.uniprot.org/uniprot/G7PDT5 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9541:POLR3B ^@ http://purl.uniprot.org/uniprot/A0A8J8YGM6|||http://purl.uniprot.org/uniprot/G7PI40 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9541:TRAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV36 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/9541:RNF31 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y808|||http://purl.uniprot.org/uniprot/G7P9X8 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9541:SEC61G ^@ http://purl.uniprot.org/uniprot/A0A2K5X404 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:WDR35 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG25|||http://purl.uniprot.org/uniprot/A0A2K5WG69 ^@ Function|||Subcellular Location Annotation ^@ As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.|||centrosome|||cilium basal body http://togogenome.org/gene/9541:EPHB6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5C5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PSMA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W387 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9541:LOC102122418 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3G2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HOXA6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSD7|||http://purl.uniprot.org/uniprot/G7P0P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:LOC102141219 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIS1|||http://purl.uniprot.org/uniprot/G8F2Z1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:EXOC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/9541:TSSC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X637 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TSSC4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DA24 ^@ Similarity|||Subunit ^@ Belongs to the CCNDBP1 family.|||Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. http://togogenome.org/gene/9541:BRINP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF47|||http://purl.uniprot.org/uniprot/G7PRK2 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9541:LOC101867398 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGS2 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/9541:TAS2R16 ^@ http://purl.uniprot.org/uniprot/A0A7N9CVE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:CNN1 ^@ http://purl.uniprot.org/uniprot/G7PZF6 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/9541:TUBA4A ^@ http://purl.uniprot.org/uniprot/P68367 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.|||Although this tubulin does not encode a C-terminal tyrosine, a C-terminal tyrosine can be added post-translationally by the tubulin tyrosine ligase (TTL). It can then undergo a detyrosination cycle by the tubulin tyrosine carboxypeptidase (KIAA0895L/MATCAP).|||Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with CFAP157 (By similarity).|||Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.|||Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity).|||Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility.|||The MREC motif may be critical for tubulin autoregulation.|||This tubulin does not have a C-terminal tyrosine.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/9541:MRPL11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSM2|||http://purl.uniprot.org/uniprot/G7PP94 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/9541:LOC102128179 ^@ http://purl.uniprot.org/uniprot/A0A8J8XL53|||http://purl.uniprot.org/uniprot/G7P5Z2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ZKSCAN8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTZ8|||http://purl.uniprot.org/uniprot/G7P3S3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PPP1R3C ^@ http://purl.uniprot.org/uniprot/A0A2K5X6W1 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/9541:ADGRL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4I3|||http://purl.uniprot.org/uniprot/A0A2K5X4J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:EXOC6 ^@ http://purl.uniprot.org/uniprot/A0A7N9CLZ1 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/9541:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A2K5WK38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:AXIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM28 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SPIC ^@ http://purl.uniprot.org/uniprot/A0A2K5WBK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:KCNAB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Z8|||http://purl.uniprot.org/uniprot/A0A7N9DCB8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane|||Monomer.|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/9541:SLC6A16 ^@ http://purl.uniprot.org/uniprot/G7PY67 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TOR3A ^@ http://purl.uniprot.org/uniprot/A0A2K5WW44 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/9541:NUCB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKW3 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/9541:JRK ^@ http://purl.uniprot.org/uniprot/G7PD20 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PGGT1B ^@ http://purl.uniprot.org/uniprot/A0A2K5WTH1|||http://purl.uniprot.org/uniprot/G7P826 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/9541:NANOS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ98|||http://purl.uniprot.org/uniprot/G7PXX8 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/9541:LOC102134569 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQZ0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/9541:TSFM ^@ http://purl.uniprot.org/uniprot/A0A2K5U4Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion http://togogenome.org/gene/9541:FABP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFN5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:NINJ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/9541:UPK1B ^@ http://purl.uniprot.org/uniprot/A0A8J8YPH5|||http://purl.uniprot.org/uniprot/G7NXN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:KCNK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/9541:TBXAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UH73 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:STXBP5L ^@ http://purl.uniprot.org/uniprot/A0A2K5U0F5|||http://purl.uniprot.org/uniprot/A0A2K5U0G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/9541:TMEM167A ^@ http://purl.uniprot.org/uniprot/A0A7N9DD82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/9541:ACTA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1C8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:A4GNT ^@ http://purl.uniprot.org/uniprot/A0A2K5VVL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A2K5WHV9|||http://purl.uniprot.org/uniprot/G7Q290 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9541:NAP1L2 ^@ http://purl.uniprot.org/uniprot/G8F2R5 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9541:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/9541:SPATA6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5E4 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/9541:B3GNT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:INTS8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/9541:CDH18 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPM6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:INO80 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMV7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/9541:CKMT2 ^@ http://purl.uniprot.org/uniprot/G7P7V7 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9541:CDK10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3L2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WYG8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:PLA2G12A ^@ http://purl.uniprot.org/uniprot/A0A2K5TPG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/9541:GSTO2 ^@ http://purl.uniprot.org/uniprot/A0A023JBX8|||http://purl.uniprot.org/uniprot/A0A2K5TM32|||http://purl.uniprot.org/uniprot/A0A8J8Y1F3|||http://purl.uniprot.org/uniprot/G7PDX3 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/9541:SPEM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HSBP1 ^@ http://purl.uniprot.org/uniprot/Q4R7N4 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/9541:LMX1B ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ERC2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D4D1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:NR6A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:NXPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9541:KCTD16 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWN2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:IRF6 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5G7|||http://purl.uniprot.org/uniprot/A0A8J8XYR9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:RBP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRQ6|||http://purl.uniprot.org/uniprot/G7P027 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:DCPS ^@ http://purl.uniprot.org/uniprot/A0A7N9CFJ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/9541:SLC1A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEU4|||http://purl.uniprot.org/uniprot/A0A2K5VEW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9541:GPR171 ^@ http://purl.uniprot.org/uniprot/A0A2K5US76 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:TEKT3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPQ6|||http://purl.uniprot.org/uniprot/G7PTQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/9541:GIMAP8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKR5|||http://purl.uniprot.org/uniprot/G7P201 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9541:CDC42EP4 ^@ http://purl.uniprot.org/uniprot/I7GEW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/9541:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5I0|||http://purl.uniprot.org/uniprot/A0A2K5X5L8|||http://purl.uniprot.org/uniprot/A0A2K5X624 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/9541:UCP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:STARD3NL ^@ http://purl.uniprot.org/uniprot/A0A2K5VI54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Membrane http://togogenome.org/gene/9541:MRGPRF ^@ http://purl.uniprot.org/uniprot/I7GAT0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:UTP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAS10 family.|||nucleolus http://togogenome.org/gene/9541:MX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSV3|||http://purl.uniprot.org/uniprot/A0A8J8XMP4 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9541:GLUL ^@ http://purl.uniprot.org/uniprot/A0A7N9CVE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamine synthetase family.|||Cell membrane|||Membrane|||Microsome|||Mitochondrion http://togogenome.org/gene/9541:TMEM14B ^@ http://purl.uniprot.org/uniprot/A0A2K5VR38 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/9541:MON1A ^@ http://purl.uniprot.org/uniprot/Q95KG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MON1/SAND family.|||Interacts with CCZ1 (By similarity). Found in a complex with RMC1, CCZ1, MON1A and MON1B (By similarity). The MON1A-CCZ1B complex interacts with RIMOC1 (By similarity). The MON1A-CCZ1B complex interacts with RAB7A and this interaction is enhanced in the presence of RIMOC1 (By similarity).|||Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. http://togogenome.org/gene/9541:RNASE1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAJ9|||http://purl.uniprot.org/uniprot/G7P9M4 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:MAP1LC3B ^@ http://purl.uniprot.org/uniprot/A0A7N9C6Y1 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:POP7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVN3|||http://purl.uniprot.org/uniprot/G7P0D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/9541:RNF20 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX05 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/9541:MCTP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJI3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PARP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/9541:ARF3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CGG1|||http://purl.uniprot.org/uniprot/G8F594|||http://purl.uniprot.org/uniprot/Q2PG54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9541:RBKS ^@ http://purl.uniprot.org/uniprot/A0A8J8XKD9|||http://purl.uniprot.org/uniprot/G7PLX7 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/9541:NXF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm http://togogenome.org/gene/9541:PARK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VY13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/9541:LOC102133631 ^@ http://purl.uniprot.org/uniprot/A0A7N9CTH0 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/9541:MGAT4B ^@ http://purl.uniprot.org/uniprot/A0A2K5UN73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 54 family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:KALRN ^@ http://purl.uniprot.org/uniprot/A0A2K5VIL2|||http://purl.uniprot.org/uniprot/A0A2K5VJC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9541:FAM229B ^@ http://purl.uniprot.org/uniprot/A5LFY3|||http://purl.uniprot.org/uniprot/G7P3M5 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/9541:VAT1L ^@ http://purl.uniprot.org/uniprot/A0A8J8YT23|||http://purl.uniprot.org/uniprot/G7Q1P8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/9541:PNLIPRP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5URK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:PPIP5K2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZZ2|||http://purl.uniprot.org/uniprot/A0A2K5UZZ9|||http://purl.uniprot.org/uniprot/A0A2K5V029|||http://purl.uniprot.org/uniprot/A0A8J8Y795 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/9541:LOC102121517 ^@ http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:MRRF ^@ http://purl.uniprot.org/uniprot/A0A2K5VLI5 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/9541:ZNF483 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVJ3|||http://purl.uniprot.org/uniprot/G8F3G3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:APOC2 ^@ http://purl.uniprot.org/uniprot/A2V9Y5|||http://purl.uniprot.org/uniprot/P18658 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apolipoprotein C2 family.|||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase.|||Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.|||Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.|||Secreted http://togogenome.org/gene/9541:CACNA1D ^@ http://purl.uniprot.org/uniprot/A0A2K5X3X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/9541:ELF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1K2|||http://purl.uniprot.org/uniprot/A0A2K5W1M3|||http://purl.uniprot.org/uniprot/A0A7N9IDC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:NSF ^@ http://purl.uniprot.org/uniprot/A0A2K5V7I5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/9541:HBM ^@ http://purl.uniprot.org/uniprot/A0A2K5W0M5 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/9541:PUS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSS2 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/9541:MEIS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2L5|||http://purl.uniprot.org/uniprot/A0A2K5U2L9|||http://purl.uniprot.org/uniprot/A0A2K5U2N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9541:SRP54 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7F2|||http://purl.uniprot.org/uniprot/G7PA28|||http://purl.uniprot.org/uniprot/Q4R965 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity).|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity).|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.|||Cytoplasm|||Endoplasmic reticulum|||Nucleus speckle|||The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).|||The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. http://togogenome.org/gene/9541:MPZ ^@ http://purl.uniprot.org/uniprot/A0A2K5TVH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the myelin P0 protein family.|||Cell membrane|||Homodimer and homotetramer.|||Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.|||Membrane http://togogenome.org/gene/9541:RSPO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIC7 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/9541:C18H18orf25 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZE1|||http://purl.uniprot.org/uniprot/A0A8J8YLS4|||http://purl.uniprot.org/uniprot/G7PWQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CHMP2B ^@ http://purl.uniprot.org/uniprot/A0A8J8XYL2|||http://purl.uniprot.org/uniprot/G7NZ52 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:DEFA6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGN9|||http://purl.uniprot.org/uniprot/G7PCC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-defensin family.|||Secreted http://togogenome.org/gene/9541:DENND6A ^@ http://purl.uniprot.org/uniprot/A0A2K5VAS5|||http://purl.uniprot.org/uniprot/A0A7N9CTT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Recycling endosome http://togogenome.org/gene/9541:SPPL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W529 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9541:B4GALT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5W8|||http://purl.uniprot.org/uniprot/A0A2K5V5Z4|||http://purl.uniprot.org/uniprot/A0A8J8Y1F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9541:LOC102142948 ^@ http://purl.uniprot.org/uniprot/G7NZ60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SCFD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ06 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:SP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PTPN6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/9541:WSCD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJL6 ^@ Function|||Similarity ^@ Belongs to the WSCD family.|||Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. http://togogenome.org/gene/9541:TAX1BP3 ^@ http://purl.uniprot.org/uniprot/I7GLD5 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.|||Nucleus http://togogenome.org/gene/9541:WASF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8K7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9541:PFKFB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V950|||http://purl.uniprot.org/uniprot/G7Q2U3 ^@ Similarity ^@ In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/9541:JAK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system http://togogenome.org/gene/9541:SEC62 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6F9|||http://purl.uniprot.org/uniprot/G7NZF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:ESCO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VNS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FAM214B ^@ http://purl.uniprot.org/uniprot/A0A2K5VGE7|||http://purl.uniprot.org/uniprot/Q4R676 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATOS family.|||Nucleus|||The protein contains a transactivation domain (TAD) which may be required for transcriptional activation of a subset of target genes.|||Transcription regulator that may syncronize transcriptional and translational programs. http://togogenome.org/gene/9541:KCND2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/9541:SUPT20H ^@ http://purl.uniprot.org/uniprot/A0A2K5UYT4|||http://purl.uniprot.org/uniprot/A0A2K5UYW4 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/9541:PRDM10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UT82 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:IL13RA1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 5 subfamily.|||Membrane http://togogenome.org/gene/9541:ESS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W123 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/9541:RRP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||Component of the eNoSC complex.|||Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.|||nucleolus http://togogenome.org/gene/9541:EDN2 ^@ http://purl.uniprot.org/uniprot/G7NUE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/9541:LIX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7H8 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/9541:GNA11 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV53 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9541:PPP1R12A ^@ http://purl.uniprot.org/uniprot/A0A2K5WH94 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/9541:RPS18 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0I8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9541:LOC102121548 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ29 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the osteocalcin/matrix Gla protein family.|||Binds strongly to apatite and calcium.|||Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.|||Secreted http://togogenome.org/gene/9541:PTGER3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLN4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:TMOD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWU7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:SYF2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSR6|||http://purl.uniprot.org/uniprot/G7NVW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/9541:ICAM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/9541:GOLM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP08|||http://purl.uniprot.org/uniprot/A0A2K5UP24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/9541:KLC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/9541:NSMCE4A ^@ http://purl.uniprot.org/uniprot/A0A2K5X6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/9541:APOLD1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CPN4 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9541:RXRG ^@ http://purl.uniprot.org/uniprot/A0A8J8XR23|||http://purl.uniprot.org/uniprot/G7NU27 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/9541:KEG98_p13 ^@ http://purl.uniprot.org/uniprot/C3W4Y5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:NDFIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3P9 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9541:CLK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0K8|||http://purl.uniprot.org/uniprot/A0A7N9CE55 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:WNT9B ^@ http://purl.uniprot.org/uniprot/A0A7N9DG84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:DLK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSZ3|||http://purl.uniprot.org/uniprot/G8F4F1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:EGR2 ^@ http://purl.uniprot.org/uniprot/G7PDE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/9541:DPY19L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/9541:CDH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V299 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HNMT ^@ http://purl.uniprot.org/uniprot/A0A2K5VBJ8 ^@ Function|||Subunit ^@ Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.|||Monomer. http://togogenome.org/gene/9541:SPACA4 ^@ http://purl.uniprot.org/uniprot/G7PY25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPACA4/bouncer family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PIGF ^@ http://purl.uniprot.org/uniprot/A0A2K5VGY5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:CFAP126 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRH1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/9541:RABGGTB ^@ http://purl.uniprot.org/uniprot/A0A2K5WEG7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/9541:CLIC1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CK20 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Endoplasmic reticulum|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||Nucleus membrane http://togogenome.org/gene/9541:FAM126B ^@ http://purl.uniprot.org/uniprot/A0A2K5V065|||http://purl.uniprot.org/uniprot/G7PL62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:COQ10A ^@ http://purl.uniprot.org/uniprot/A0A2K5UKY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/9541:POLR2F ^@ http://purl.uniprot.org/uniprot/A0A2K5U2B7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/9541:LOC102116629 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRG3|||http://purl.uniprot.org/uniprot/A0A8J8XC80 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9541:ORMDL3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRK2|||http://purl.uniprot.org/uniprot/G7PUM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/9541:MPP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL68 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9541:PTPN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/9541:ALDH9A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7N6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:MYH11 ^@ http://purl.uniprot.org/uniprot/A0A2K5W527|||http://purl.uniprot.org/uniprot/A0A2K5W551|||http://purl.uniprot.org/uniprot/A0A2K5W599 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:KCNK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJU3|||http://purl.uniprot.org/uniprot/A0A2K5TJU7|||http://purl.uniprot.org/uniprot/A0A8J8YP25|||http://purl.uniprot.org/uniprot/G7NTZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:SPCS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PAX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/9541:PCYT1A ^@ http://purl.uniprot.org/uniprot/A0A7N9CXD5 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9541:PTHLH ^@ http://purl.uniprot.org/uniprot/A0A2K5W832 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Cytoplasm|||Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.|||Nucleus|||Osteostatin is a potent inhibitor of osteoclastic bone resorption.|||PTHrP interacts with PTH1R (via N-terminal extracellular domain).|||Secreted|||There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. http://togogenome.org/gene/9541:ZIC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMG3 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9541:LOC102115644 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP84 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:SYK ^@ http://purl.uniprot.org/uniprot/A0A2K5V796 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. http://togogenome.org/gene/9541:DPH3 ^@ http://purl.uniprot.org/uniprot/G7NY17|||http://purl.uniprot.org/uniprot/Q4R312 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH3 family.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase (By similarity). Interacts with SERGEF (By similarity).|||Cytoplasm|||Nucleus|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).|||The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function. http://togogenome.org/gene/9541:GPR137 ^@ http://purl.uniprot.org/uniprot/A0A7N9CBZ7 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/9541:TMEM218 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM218 family.|||May be involved in ciliary biogenesis or function.|||Membrane|||cilium http://togogenome.org/gene/9541:TERF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X903 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9541:GDPGP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/9541:HAPLN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFA9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TMTC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKT3|||http://purl.uniprot.org/uniprot/A0A8J8XP16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/9541:TFIP11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/9541:IRF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5R1|||http://purl.uniprot.org/uniprot/G8F5X0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:YIPF4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRH1|||http://purl.uniprot.org/uniprot/G7PLZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:AHSA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKD1|||http://purl.uniprot.org/uniprot/G7PB34 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/9541:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1N2|||http://purl.uniprot.org/uniprot/A0A8J8XR58|||http://purl.uniprot.org/uniprot/G7PAF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9541:RPS29 ^@ http://purl.uniprot.org/uniprot/A0A2K5WR94 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/9541:RETNLB ^@ http://purl.uniprot.org/uniprot/A0A7N9CMW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/9541:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRK2|||http://purl.uniprot.org/uniprot/G7PTJ7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/9541:MAOB ^@ http://purl.uniprot.org/uniprot/A0A2K5TQG7 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/9541:NHP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS32|||http://purl.uniprot.org/uniprot/G7P715 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/9541:SYNGR4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFX6|||http://purl.uniprot.org/uniprot/A0A2K5WG58|||http://purl.uniprot.org/uniprot/G8F5G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/9541:CUL4A ^@ http://purl.uniprot.org/uniprot/A0A2K5VIT2 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:BRINP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNH3 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/9541:LOC102131904 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat fritz family.|||Cell membrane|||Membrane|||cilium axoneme http://togogenome.org/gene/9541:LUC7L3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY02|||http://purl.uniprot.org/uniprot/A0A2K5UY32|||http://purl.uniprot.org/uniprot/G7PUB4 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9541:ANKRD13C ^@ http://purl.uniprot.org/uniprot/A0A2K5TT21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:INO80D ^@ http://purl.uniprot.org/uniprot/A0A2K5TUN5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SDHD ^@ http://purl.uniprot.org/uniprot/A0A2K5VD68|||http://purl.uniprot.org/uniprot/A0A8J8XED5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A2K5ULI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Hyccin family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:FICD ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0R5|||http://purl.uniprot.org/uniprot/G7PI52 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/9541:TES ^@ http://purl.uniprot.org/uniprot/A0A2K5UCY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||focal adhesion http://togogenome.org/gene/9541:DIABLO ^@ http://purl.uniprot.org/uniprot/I7GJM7 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/9541:C11H12orf57 ^@ http://purl.uniprot.org/uniprot/A0A7N9IC88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0456 family.|||Cytoplasm http://togogenome.org/gene/9541:WWOX ^@ http://purl.uniprot.org/uniprot/A0A2K5W5D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Golgi apparatus|||Lysosome|||Mitochondrion http://togogenome.org/gene/9541:SEPTIN8 ^@ http://purl.uniprot.org/uniprot/I7GH31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:TRIM32 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEP3|||http://purl.uniprot.org/uniprot/G7PRK5 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9541:ARPC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/9541:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWF3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:B4GALNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/9541:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCA2|||http://purl.uniprot.org/uniprot/A0A2K5VCC5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/9541:COG4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:CBX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X776 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PYCR2 ^@ http://purl.uniprot.org/uniprot/Q4R6W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Cytoplasm|||Homodecamer; composed of 5 homodimers. Interacts with LTO1.|||Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity).|||Mitochondrion http://togogenome.org/gene/9541:LOC102122758 ^@ http://purl.uniprot.org/uniprot/A0A7N9I9L6 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/9541:NT5C2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBL1|||http://purl.uniprot.org/uniprot/G7PDV7 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9541:ERBB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XF73|||http://purl.uniprot.org/uniprot/G7PIG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9541:METTL26 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWP3 ^@ Similarity ^@ Belongs to the UPF0585 family. http://togogenome.org/gene/9541:SLC26A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. http://togogenome.org/gene/9541:LOC102125919 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/9541:TRHR ^@ http://purl.uniprot.org/uniprot/A0A2K5UTF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/9541:MAB21L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TP07 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9541:BCLAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXE7|||http://purl.uniprot.org/uniprot/A0A7N9IGT3 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9541:LOC102122430 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR05 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:CPQ ^@ http://purl.uniprot.org/uniprot/A0A2K5W7T5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome http://togogenome.org/gene/9541:F9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCV8|||http://purl.uniprot.org/uniprot/G7Q1U2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:SCN1B ^@ http://purl.uniprot.org/uniprot/A0A2K5V251 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:EMG1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XFU7|||http://purl.uniprot.org/uniprot/G7PJP2 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/9541:KIF20A ^@ http://purl.uniprot.org/uniprot/A0A2K5WY13 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:PDGFC ^@ http://purl.uniprot.org/uniprot/A0A2K5V0S6 ^@ Caution|||Similarity ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RACK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEN4|||http://purl.uniprot.org/uniprot/Q4R7Y4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.|||Cell membrane|||Cytoplasm|||Interacts with CPNE3 (By similarity). May interact with ABCB4 (By similarity). Component of the small (40S) ribosomal subunit. Exists as a monomer and also forms oligomers. Binds NHERF1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cell migration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1. Interacts with HRAS. Interacts with LARP4B. Interacts with PKD2L1 (By similarity).|||Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration (By similarity). Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity).|||Nucleus|||Perikaryon|||Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC (By similarity).|||dendrite|||perinuclear region http://togogenome.org/gene/9541:RSBN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/9541:PPIL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNT8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:PTP4A3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRA9|||http://purl.uniprot.org/uniprot/G7PD16 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/9541:ID3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:C6H5orf24 ^@ http://purl.uniprot.org/uniprot/G7P8B2 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/9541:PTPN12 ^@ http://purl.uniprot.org/uniprot/A0A2K5USI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.|||Cytoplasm|||Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. http://togogenome.org/gene/9541:NOL12 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD50 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP17 family.|||Interacts with KIAA1191.|||nucleolus http://togogenome.org/gene/9541:SPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U068|||http://purl.uniprot.org/uniprot/A0A8J8XDI2 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9541:CADM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0W6|||http://purl.uniprot.org/uniprot/A0A2K5U0X1 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9541:PIK3CA ^@ http://purl.uniprot.org/uniprot/A0A8J8XAB5|||http://purl.uniprot.org/uniprot/G7NZ32 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:FN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0E3|||http://purl.uniprot.org/uniprot/A0A2K5V0E4|||http://purl.uniprot.org/uniprot/A0A2K5V0I5 ^@ Function ^@ Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. http://togogenome.org/gene/9541:PDCL ^@ http://purl.uniprot.org/uniprot/A0A2K5W0N3 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9541:LOC102123270 ^@ http://purl.uniprot.org/uniprot/G7P5I5|||http://purl.uniprot.org/uniprot/Q4R648 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIb family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PTPRD ^@ http://purl.uniprot.org/uniprot/A0A2K5V177 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. http://togogenome.org/gene/9541:DNAJC27 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHN1 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/9541:DNAJC16 ^@ http://purl.uniprot.org/uniprot/A0A2K5X618 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Plays an important role in regulating the size of autophagosomes during the formation process. http://togogenome.org/gene/9541:SF3B4 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0H7|||http://purl.uniprot.org/uniprot/G7NTS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/9541:COPZ2 ^@ http://purl.uniprot.org/uniprot/I7GJN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/9541:TBC1D24 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWN6|||http://purl.uniprot.org/uniprot/A0A2K5VWS7 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse http://togogenome.org/gene/9541:PRMT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U736|||http://purl.uniprot.org/uniprot/A0A2K5U799 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ENDOU ^@ http://purl.uniprot.org/uniprot/A0A2K5TLU3 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/9541:XPA ^@ http://purl.uniprot.org/uniprot/A0A2K5TWB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/9541:IL17A ^@ http://purl.uniprot.org/uniprot/A0A2K5TTB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/9541:PDE5A ^@ http://purl.uniprot.org/uniprot/A0A2K5U205|||http://purl.uniprot.org/uniprot/A0A2K5U243|||http://purl.uniprot.org/uniprot/A0A8J8Y3N4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:MAP3K12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ06 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||May be an activator of the JNK/SAPK pathway. http://togogenome.org/gene/9541:STK38 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLB9|||http://purl.uniprot.org/uniprot/G7P3B9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:TMEM150B ^@ http://purl.uniprot.org/uniprot/A0A8J8XUG3|||http://purl.uniprot.org/uniprot/G7PYY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PNKD ^@ http://purl.uniprot.org/uniprot/A0A2K5TS50|||http://purl.uniprot.org/uniprot/I7G6D8 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/9541:LRRTM3 ^@ http://purl.uniprot.org/uniprot/Q9BGP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRTM family.|||Cell membrane|||May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity).|||Postsynaptic cell membrane http://togogenome.org/gene/9541:GABRE ^@ http://purl.uniprot.org/uniprot/A0A2K5WCD4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:NFIB ^@ http://purl.uniprot.org/uniprot/A0A2K5W5D7|||http://purl.uniprot.org/uniprot/G7PSC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/9541:YTHDF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFT2|||http://purl.uniprot.org/uniprot/A0A2K5VFV9|||http://purl.uniprot.org/uniprot/A0A2K5VFW1 ^@ Function|||Similarity ^@ Belongs to the YTHDF family.|||Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. http://togogenome.org/gene/9541:PHF1 ^@ http://purl.uniprot.org/uniprot/G7P2T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Polycomblike family.|||Nucleus http://togogenome.org/gene/9541:MS4A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TY64 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/9541:ADAT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYR1|||http://purl.uniprot.org/uniprot/G7P308 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Cytoplasm|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/9541:SEPTIN12 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJG8|||http://purl.uniprot.org/uniprot/G7Q0E9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:DEFB110 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:GAB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XW79|||http://purl.uniprot.org/uniprot/G7P6C4 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9541:AP1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0N0|||http://purl.uniprot.org/uniprot/A0A2K5X0Q6 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9541:TAS2R1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:ZUP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Z7 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C78 family. ZUFSP subfamily.|||Interacts with RPA1 and RPA2. http://togogenome.org/gene/9541:RGS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2I1|||http://purl.uniprot.org/uniprot/G7NXE1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||nucleolus http://togogenome.org/gene/9541:NPL ^@ http://purl.uniprot.org/uniprot/A0A2K5WFI8|||http://purl.uniprot.org/uniprot/A0A8J8XEN5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family. NanA subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/9541:GUCA2B ^@ http://purl.uniprot.org/uniprot/A0A8J8YK19|||http://purl.uniprot.org/uniprot/G7NUE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/9541:LIPM ^@ http://purl.uniprot.org/uniprot/A0A2K5U9C7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9541:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD45 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/9541:SNRPG ^@ http://purl.uniprot.org/uniprot/A0A2K5WTS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/9541:VBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZS6|||http://purl.uniprot.org/uniprot/A0A8J8XUR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/9541:LIN7C ^@ http://purl.uniprot.org/uniprot/A0A2K5VUH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9541:SARS1 ^@ http://purl.uniprot.org/uniprot/Q4R4U9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule may bind across the dimer. Interacts with SIRT2. Interacts with METTL6; interaction is required for the tRNA N(3)-methylcytidine methyltransferase activity of METTL6.|||Nucleus http://togogenome.org/gene/9541:CFAP97D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8Q6 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/9541:MRPS17 ^@ http://purl.uniprot.org/uniprot/A0A7N9CHQ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/9541:KIT ^@ http://purl.uniprot.org/uniprot/A0A2K5U4C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SEC11C ^@ http://purl.uniprot.org/uniprot/A0A8J8YDW3|||http://purl.uniprot.org/uniprot/G7PWV4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:TACR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:AP1S3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Membrane|||clathrin-coated pit http://togogenome.org/gene/9541:COPS8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCZ2|||http://purl.uniprot.org/uniprot/G7PKD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A7N9D3Z0|||http://purl.uniprot.org/uniprot/A0A8J8YFY2|||http://purl.uniprot.org/uniprot/G7P4S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:CSGALNACT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:SLC39A10 ^@ http://purl.uniprot.org/uniprot/G7PL28 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CACYBP ^@ http://purl.uniprot.org/uniprot/Q4R4P3 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1 (By similarity). Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity).|||Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity).|||Nucleus|||Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations (By similarity). http://togogenome.org/gene/9541:GALE ^@ http://purl.uniprot.org/uniprot/A0A8J8XC21|||http://purl.uniprot.org/uniprot/Q4R651 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/9541:AUH ^@ http://purl.uniprot.org/uniprot/A0A2K5WCU2|||http://purl.uniprot.org/uniprot/A0A2K5WCX1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:RFTN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TM9SF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W768 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/9541:NUP50 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJC8|||http://purl.uniprot.org/uniprot/Q4R414 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9541:DYNLL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y705|||http://purl.uniprot.org/uniprot/G7PJ46|||http://purl.uniprot.org/uniprot/P61273 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).|||Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1.|||Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944'). Interacts with BICD2. Interacts with BCAS1. Interacts with Bassoon/BSN (By similarity). Interacts with HDAC6 (By similarity). Interacts with TPPP (By similarity). Interacts with AMBRA1 (via TQT motifs); tethering AMBRA1 to the cytoskeleton (By similarity). Interacts with FAM83D/CHICA (via C-terminus) (By similarity). Interacts with HMMR, SPAG5/Astrin and KNSTRN/Kinastrin (By similarity). Interacts with TLK2 (By similarity). Interacts with NOS1 (By similarity).|||Mitochondrion|||Nucleus|||Phosphorylation at Ser-88 appears to control the dimer-monomer transition.|||Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.|||Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity).|||centrosome|||cytoskeleton http://togogenome.org/gene/9541:TP53 ^@ http://purl.uniprot.org/uniprot/G7PTI9|||http://purl.uniprot.org/uniprot/P56423 ^@ Cofactor|||Disease Annotation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Acetylation of Lys-382 by EP300. Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence. Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner. Acetylation at Lys-381 increases stability. Deacetylation at Lys-381 by SIRT6 decreases its stability, thereby regulating cell senescence.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Cytoplasm|||Endoplasmic reticulum|||Forms homodimers and homotetramers (By similarity). Binds DNA as a homotetramer. Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. Interacts (via C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect. Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and TP53INP1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit histone H1 and prevent transactivation activity. Interacts with ARMC10, BANP, CDKN2AIP, NUAK1, STK11/LKB1, UHRF2 and E4F. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1. Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquitination and degradation of TP53. Interacts (phosphorylated at Ser-15 by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell proliferation. Interacts with PPP2R2A. Interacts with AURKA, DAXX, BRD7 and TRIM24. Interacts (when monomethylated at Lys-382) with L3MBTL1. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Interacts with AURKB, SETD2, UHRF2 and NOC2L. Interacts (via N-terminus) with PTK2/FAK1; this promotes ubiquitination by MDM2. Interacts with PTK2B/PYK2; this promotes ubiquitination by MDM2. Interacts with PRKCG. Interacts with PPIF; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by cyclosporin A (CsA). Interacts with SNAI1; the interaction induces SNAI1 degradation via MDM2-mediated ubiquitination and inhibits SNAI1-induced cell invasion. Interacts with KAT6A. Interacts with UBC9. Interacts with ZNF385B; the interaction is direct. Interacts (via DNA-binding domain) with ZNF385A; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest (By similarity). Interacts with ANKRD2. Interacts with RFFL and RNF34; involved in p53/TP53 ubiquitination. Interacts with MTA1 and COP1. Interacts with CCAR2 (via N-terminus). Interacts with MORC3. Interacts (via C-terminus) with POU4F2 (via C-terminus). Interacts (via oligomerization region) with NOP53; the interaction is direct and may prevent the MDM2-mediated proteasomal degradation of TP53. Interacts with AFG1L; mediates mitochondrial translocation of TP53. Interacts with UBD (By similarity). Interacts with TAF6 (By similarity). Interacts with C10orf90/FATS; the interaction inhibits binding of TP53 and MDM2 (By similarity). Interacts with NUPR1; interaction is stress-dependent. Forms a complex with EP300 and NUPR1; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (By similarity). Interacts with PRMT5 in response to DNA damage; the interaction is TTC5/STRAP dependent (By similarity). Interacts with PPP1R13L (via SH3 domain and ANK repeats); the interaction inhibits pro-apoptotic activity of p53/TP53 (By similarity). Interacts with PPP1R13B/ASPP1 and TP53BP2/ASPP2; the interactions promotes pro-apoptotic activity (By similarity). When phosphorylated at Ser-15, interacts with DDX3X and gamma-tubulin (By similarity). Interacts with KAT7/HBO1; leading to inhibit histone acetyltransferase activity of KAT7/HBO1 (By similarity). Interacts (via N-terminus) with E3 ubiquitin-protein ligase MUL1; the interaction results in ubiquitination of cytoplasmic TP53 at Lys-24 and subsequent proteasomal degradation (By similarity). Interacts with S100A4; this interaction promotes TP53 degradation (By similarity). Interacts with TTC5/STRAP; the interaction may result in increased mitochondrial-dependent apoptosis (By similarity). Interacts with NQO1; this interaction is NADH-dependent, stabilizes TP53 in response to oxidative stress and protects it from ubiquitin-independent degradation by the 20S proteasome (By similarity). Interacts with DAZAP2 at TP53 target gene promoters; the interaction is triggered by DNA damage and leads to modulation of the expression of a subset of TP53 target genes, reducing DNA damage-induced cell death by limiting the expression of cell death-mediating TP53 target genes (By similarity). Interacts (via N-terminus) with ZNF768 (via zinc-finger domains); interaction might be facilitated by TP53 oligomerization state (By similarity). Forms a ternary complex with ALDOB and G6PD; this interaction is direct. ALDOB stabilizes the complex inhibiting G6PD activity and keeping oxidative pentose phosphate metabolism in check. Interacts with MORN3; the interactions mediate post-transcriptional modifications of TP53 by MDM2 and SIRT1 (By similarity).|||Mitochondrion matrix|||Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity. Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-370. Dimethylated at Lys-373 by EHMT1 and EHMT2. Monomethylated at Lys-382 by KMT5A, promoting interaction with L3MBTL1 and leading to repress transcriptional activity. Demethylation of dimethylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated transcriptional activation (By similarity). Monomethylated at Arg-333 and dimethylated at Arg-335 and Arg-337 by PRMT5; methylation is increased after DNA damage and might possibly affect TP53 target gene specificity (By similarity).|||Nucleus|||PML body|||Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter (By similarity). Phosphorylated on Thr-18 by VRK1, which may prevent the interaction with MDM2. Phosphorylated on Ser-20 by CHEK2 in response to DNA damage, which prevents ubiquitination by MDM2. Phosphorylated on Ser-20 by PLK3 in response to reactive oxygen species (ROS), promoting p53/TP53-mediated apoptosis. Phosphorylated on Thr-55 by TAF1 which promotes MDM2-mediated TP53 degradation. Phosphorylated on Ser-33 by CDK7 in a CAK complex in response to DNA damage. Phosphorylated by HIPK1. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Stabilized by CDK5-mediated phosphorylation in response to genotoxic and oxidative stresses at Ser-15, Ser-33 and Ser-46, leading to accumulation of p53/TP53, particularly in the nucleus, thus inducing the transactivation of p53/TP53 target genes. Phosphorylated by DYRK2 at Ser-46 in response to genotoxic stress. Phosphorylated at Ser-315 and Ser-392 by CDK2 in response to DNA-damage (By similarity). Phosphorylation at Ser-15 is required for interaction with DDX3X and gamma-tubulin (By similarity).|||Sumoylated with SUMO1. Sumoylated at Lys-386 by UBC9 (By similarity).|||Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation. Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity).|||Ubiquitinated by MDM2 and SYVN1, which leads to proteasomal degradation. Ubiquitinated by RFWD3, which works in cooperation with MDM2 and may catalyze the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. Ubiquitinated by MKRN1, which leads to proteasomal degradation. Deubiquitinated by USP10, leading to stabilize it. Ubiquitinated by TRIM24, RFFL, RNF34 and RNF125, which leads to proteasomal degradation. Ubiquitination by TOPORS induces degradation. Deubiquitination by USP7, leading to stabilize it. Ubiquitinated by COP1, which leads to proteasomal degradation (By similarity). Ubiquitination and subsequent proteasomal degradation is negatively regulated by CCAR2 (By similarity). Polyubiquitinated by C10orf90/FATS, polyubiquitination is 'Lys-48'-linkage independent and non-proteolytic, leading to TP53 stabilization (By similarity). Polyubiquitinated by MUL1 at Lys-24 which leads to proteasomal degradation (By similarity).|||centrosome|||p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer. http://togogenome.org/gene/9541:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK98 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cell junction|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Lipid droplet|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Postsynaptic density membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle|||growth cone http://togogenome.org/gene/9541:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0E9|||http://purl.uniprot.org/uniprot/A0A2K5V0F2|||http://purl.uniprot.org/uniprot/A0A2K5V0K6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane|||Monomer. http://togogenome.org/gene/9541:TBK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYJ5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:AKT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8I8|||http://purl.uniprot.org/uniprot/A0A8J8YC63 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9541:AMPD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W9K5 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Homotetramer. http://togogenome.org/gene/9541:OVCA2 ^@ http://purl.uniprot.org/uniprot/G8F5I1 ^@ Similarity ^@ Belongs to the LovG family. http://togogenome.org/gene/9541:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A2K5VAN0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/9541:DLX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YK27|||http://purl.uniprot.org/uniprot/G7PKU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:THEMIS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URI2 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/9541:XK ^@ http://purl.uniprot.org/uniprot/A0A7N9CIT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/9541:CUTA ^@ http://purl.uniprot.org/uniprot/A0A2K5VJX9 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/9541:PPM1K ^@ http://purl.uniprot.org/uniprot/A0A8J8YE78|||http://purl.uniprot.org/uniprot/G7P5W4 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:EIF3J ^@ http://purl.uniprot.org/uniprot/A0A2K5UTF1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit J family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation. http://togogenome.org/gene/9541:TADA2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WT76 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:POLR2D ^@ http://purl.uniprot.org/uniprot/A0A2K5UYV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/9541:BFSP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V913|||http://purl.uniprot.org/uniprot/A0A2K5V926 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/9541:LOC102127185 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYJ1|||http://purl.uniprot.org/uniprot/A0A2K5VYL2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9541:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEN7 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/9541:CADM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0R3|||http://purl.uniprot.org/uniprot/A0A2K5X0R4|||http://purl.uniprot.org/uniprot/A0A2K5X0R9|||http://purl.uniprot.org/uniprot/A0A2K5X176|||http://purl.uniprot.org/uniprot/A0A2K5X1D0 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9541:ZCCHC17 ^@ http://purl.uniprot.org/uniprot/Q95KF9 ^@ Subcellular Location Annotation|||Subunit ^@ May interact with PNN. May associate with the 60 S ribosomal subunit (By similarity).|||nucleolus http://togogenome.org/gene/9541:C15H9orf64 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUN8 ^@ Function|||Similarity ^@ Belongs to the QNG1 protein family.|||Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly. http://togogenome.org/gene/9541:MMP26 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUI9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9541:NEK8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSY6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/9541:CCL24 ^@ http://purl.uniprot.org/uniprot/A0A7N9CBC6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:CD82 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:HS2ST1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:ACTL6A ^@ http://purl.uniprot.org/uniprot/A0A2K5UP87 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTQ8|||http://purl.uniprot.org/uniprot/A0A8J8Y0Q7|||http://purl.uniprot.org/uniprot/G7PCB4|||http://purl.uniprot.org/uniprot/Q4R372 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Nucleus|||Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).|||Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).|||The F-box is necessary for the interaction with SKP1. http://togogenome.org/gene/9541:FYN ^@ http://purl.uniprot.org/uniprot/A0A8J8XEI0|||http://purl.uniprot.org/uniprot/G7P3M8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:ADAMTS4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X742 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/9541:DRD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.|||Membrane http://togogenome.org/gene/9541:PDPR ^@ http://purl.uniprot.org/uniprot/G7Q1M1 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/9541:PCNX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9541:TIE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W685 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:CTSK ^@ http://purl.uniprot.org/uniprot/A0A805RTL9|||http://purl.uniprot.org/uniprot/P61276 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Lysosome|||Secreted|||Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. http://togogenome.org/gene/9541:CAT ^@ http://purl.uniprot.org/uniprot/A0A2K5X7W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/9541:SIM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6D0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102143756 ^@ http://purl.uniprot.org/uniprot/Q4R374 ^@ Function|||Subcellular Location Annotation ^@ Connects the two COX monomers into the physiological dimeric form.|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:FMR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U918|||http://purl.uniprot.org/uniprot/A0A2K5U936 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Stress granule|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/9541:ACVR1C ^@ http://purl.uniprot.org/uniprot/A0A2K5VZI1|||http://purl.uniprot.org/uniprot/A0A2K5VZP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:EIF3D ^@ http://purl.uniprot.org/uniprot/A0A2K5X7Q7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Cytoplasm|||Phosphorylated upon DNA damage, probably by ATM or ATR.|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/9541:CHAT ^@ http://purl.uniprot.org/uniprot/A0A2K5VTI9 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/9541:METTL3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLF4|||http://purl.uniprot.org/uniprot/G7P9P3 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9541:STX18 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Endoplasmic reticulum membrane|||Membrane|||Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. http://togogenome.org/gene/9541:BHMT ^@ http://purl.uniprot.org/uniprot/A0A8J8YGY7|||http://purl.uniprot.org/uniprot/G7P7U0 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/9541:BACE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWX5|||http://purl.uniprot.org/uniprot/A0A8J8YG33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Endosome|||Membrane|||Membrane raft|||Recycling endosome|||Secreted|||trans-Golgi network http://togogenome.org/gene/9541:NEXMIF ^@ http://purl.uniprot.org/uniprot/A0A2K5TUA9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ARL8B ^@ http://purl.uniprot.org/uniprot/A0A7N9CGD0 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Late endosome membrane|||Lysosome membrane|||axon|||spindle http://togogenome.org/gene/9541:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAS0|||http://purl.uniprot.org/uniprot/A0A8J8XXE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/9541:B3GALT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y920|||http://purl.uniprot.org/uniprot/G7PKQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:NPAS4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIW1|||http://purl.uniprot.org/uniprot/G7PP95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CCNY ^@ http://purl.uniprot.org/uniprot/A0A2K5TS85|||http://purl.uniprot.org/uniprot/A0A7N9CXY4|||http://purl.uniprot.org/uniprot/Q95LK3 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/9541:NCOA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UID3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9541:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y929|||http://purl.uniprot.org/uniprot/G7NXV0 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/9541:IDH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJA5 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/9541:RNF185 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQP9|||http://purl.uniprot.org/uniprot/G7PF83 ^@ Domain|||Function|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase.|||Endoplasmic reticulum membrane|||Mitochondrion membrane|||The RING-type zinc finger domain is responsible for E3 ligase activity. http://togogenome.org/gene/9541:KIF22 ^@ http://purl.uniprot.org/uniprot/A0A7N9CVD8|||http://purl.uniprot.org/uniprot/Q4R838 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:ITGAV ^@ http://purl.uniprot.org/uniprot/A0A2K5WCD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/9541:AP4B1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DG61 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9541:AP2B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V588 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/9541:NAA40 ^@ http://purl.uniprot.org/uniprot/A0A7N9CM48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:OPHN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWB2|||http://purl.uniprot.org/uniprot/A0A7N9IB65 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Postsynapse|||Presynapse|||dendrite http://togogenome.org/gene/9541:RPL36AL ^@ http://purl.uniprot.org/uniprot/G7Q2K4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9541:KCNA2 ^@ http://purl.uniprot.org/uniprot/G7NW44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||lamellipodium membrane|||paranodal septate junction|||synaptosome http://togogenome.org/gene/9541:ATP4B ^@ http://purl.uniprot.org/uniprot/A0A8J8XPL0|||http://purl.uniprot.org/uniprot/G7PVS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/9541:LOC101866007 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDA9 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/9541:GAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV10 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/9541:TMEM233 ^@ http://purl.uniprot.org/uniprot/A0A7N9D303 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:NAGA ^@ http://purl.uniprot.org/uniprot/A0A2K5U017 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/9541:C1H1orf74 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNI5 ^@ Similarity ^@ Belongs to the UPF0739 family. http://togogenome.org/gene/9541:POLR1F ^@ http://purl.uniprot.org/uniprot/A0A2K5VT47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA43 RNA polymerase subunit family.|||DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/9541:PKNOX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSL6|||http://purl.uniprot.org/uniprot/A0A8J8XRF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/9541:LOC102124067 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNC4|||http://purl.uniprot.org/uniprot/G7PQY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GALNT6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:UBLCP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGL9|||http://purl.uniprot.org/uniprot/G7P6S1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TIMM8A ^@ http://purl.uniprot.org/uniprot/A0A2K5X878 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/9541:ST6GALNAC6 ^@ http://purl.uniprot.org/uniprot/G8F557 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:FGF21 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYN8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:C15H9orf78 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TLS1 family.|||Nucleus http://togogenome.org/gene/9541:LOC102127670 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:KIF20B ^@ http://purl.uniprot.org/uniprot/A0A2K5X3T5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:FAM174C ^@ http://purl.uniprot.org/uniprot/A0A2K5VFT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9541:LOC102127570 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:EFNA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZR7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NKIRAS2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XI33|||http://purl.uniprot.org/uniprot/G7PUT9 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/9541:WASF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYW2|||http://purl.uniprot.org/uniprot/G8F546 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/9541:NEMF ^@ http://purl.uniprot.org/uniprot/A0A2K5UCQ5 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/9541:ZNF322 ^@ http://purl.uniprot.org/uniprot/Q4R7X8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Cytoplasm|||Interacts with POU5F1.|||Nucleus|||Significantly enhances POU5F1/OCT4-SOX2-KLF4-MYC (OSKM) mediated reprogramming of mouse embryonic fibroblasts into induced pluripotent stem cells, and can also substitute for SOX2 in this process.|||Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation. http://togogenome.org/gene/9541:GTPBP4 ^@ http://purl.uniprot.org/uniprot/Q4R5E5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/9541:HOXC5 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/9541:NOP16 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/9541:NQO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZM3 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/9541:LOC102144646 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP23|||http://purl.uniprot.org/uniprot/G7PVB2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9541:RAP2B ^@ http://purl.uniprot.org/uniprot/A0A2K5UCT0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/9541:LOC102123567 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0A2 ^@ Similarity ^@ Belongs to the LEO1 family. http://togogenome.org/gene/9541:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL91|||http://purl.uniprot.org/uniprot/A0A8J8YGF1|||http://purl.uniprot.org/uniprot/G7P7J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9541:ART1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCR3 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/9541:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W8Q8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:KIF2C ^@ http://purl.uniprot.org/uniprot/A0A2K5VIH2|||http://purl.uniprot.org/uniprot/Q95LP1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.|||In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment.|||Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.|||Nucleus|||Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.|||The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.|||Ubiquitinated.|||centromere|||cytoskeleton|||kinetochore http://togogenome.org/gene/9541:SLC6A4 ^@ http://purl.uniprot.org/uniprot/A7KAX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Membrane|||Synapse|||focal adhesion|||neuron projection http://togogenome.org/gene/9541:TRPV6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXF2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:ARF5 ^@ http://purl.uniprot.org/uniprot/I7G7I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/9541:NDRG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.|||Cytoplasm http://togogenome.org/gene/9541:SET ^@ http://purl.uniprot.org/uniprot/A0A2K5U0M4 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/9541:LDB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUY6 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9541:SUSD6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKY7|||http://purl.uniprot.org/uniprot/G7PAR2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TMEM198 ^@ http://purl.uniprot.org/uniprot/I7GF23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/9541:DPPA5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ00|||http://purl.uniprot.org/uniprot/G7P3F8 ^@ Similarity ^@ Belongs to the KHDC1 family. http://togogenome.org/gene/9541:CDH7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YM50|||http://purl.uniprot.org/uniprot/G7PW74 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102124877 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYA7|||http://purl.uniprot.org/uniprot/G7P9K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MATN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0B0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:AKT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA57 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/9541:SLC6A20 ^@ http://purl.uniprot.org/uniprot/A0A7N9D6L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9541:LOC102124177 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6K9 ^@ Similarity ^@ Belongs to the SSX family. http://togogenome.org/gene/9541:TRMT112 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLA0 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/9541:GALK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7L4 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/9541:BUD31 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTI5|||http://purl.uniprot.org/uniprot/G7P0A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/9541:TRPC5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XXH1|||http://purl.uniprot.org/uniprot/G7Q3H5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CELF1 ^@ http://purl.uniprot.org/uniprot/G7PQ93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:THOC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0N2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THOC2 family.|||Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.|||Nucleus http://togogenome.org/gene/9541:WLS ^@ http://purl.uniprot.org/uniprot/A0A2K5UNV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:SLC25A39 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKD4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:WEE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPE1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/9541:ALDH1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHE5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:TOMT ^@ http://purl.uniprot.org/uniprot/A0A2K5WTM6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/9541:PDK2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y3L1|||http://purl.uniprot.org/uniprot/Q4R567 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZS8|||http://purl.uniprot.org/uniprot/A0A2K5WZT6|||http://purl.uniprot.org/uniprot/A0A2K5X0E3|||http://purl.uniprot.org/uniprot/A0A7N9CER2 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/9541:RAB19 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/9541:LOC102129793 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0U2|||http://purl.uniprot.org/uniprot/A0A2K5W142 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted|||acrosome http://togogenome.org/gene/9541:NRM ^@ http://purl.uniprot.org/uniprot/A0A2K5X7A8|||http://purl.uniprot.org/uniprot/A0A7N9IHG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9541:SLC14A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SSBP3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAU5|||http://purl.uniprot.org/uniprot/A0A7N9CM22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GOLT1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V0D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/9541:TMED4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D1Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SMG7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXC6|||http://purl.uniprot.org/uniprot/A0A8J8YR72 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in nonsense-mediated mRNA decay. http://togogenome.org/gene/9541:COG7 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHI7|||http://purl.uniprot.org/uniprot/G7Q0Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:USP48 ^@ http://purl.uniprot.org/uniprot/A0A2K5X372|||http://purl.uniprot.org/uniprot/A0A2K5X3E9|||http://purl.uniprot.org/uniprot/A0A2K5X3Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/9541:PKIB ^@ http://purl.uniprot.org/uniprot/I7GE53 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9541:TNMD ^@ http://purl.uniprot.org/uniprot/A0A8J8YP78|||http://purl.uniprot.org/uniprot/G7Q376 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/9541:GPR65 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMR2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:HSPB8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity.|||Nucleus http://togogenome.org/gene/9541:LIMK1 ^@ http://purl.uniprot.org/uniprot/G8F3C7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/9541:ERG28 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:EHF ^@ http://purl.uniprot.org/uniprot/A0A2K5UMJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:RAD21 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/9541:TXN ^@ http://purl.uniprot.org/uniprot/A0A7N9CH45 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/9541:SLC9A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH0 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9541:TSPAN15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGL3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:LYZL4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZG4|||http://purl.uniprot.org/uniprot/G7NY74 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. http://togogenome.org/gene/9541:ATAD2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WQJ1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:LOC102125111 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:CSTF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YE71|||http://purl.uniprot.org/uniprot/Q4R7X3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102143668 ^@ http://purl.uniprot.org/uniprot/A0A2K5V7C3 ^@ Similarity|||Subunit ^@ Belongs to the GST superfamily. Theta family.|||Homodimer. http://togogenome.org/gene/9541:GPR182 ^@ http://purl.uniprot.org/uniprot/G7PIU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:COQ5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL38 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ACTR6 ^@ http://purl.uniprot.org/uniprot/G7PJA1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/9541:MOG ^@ http://purl.uniprot.org/uniprot/Q29ZP0|||http://purl.uniprot.org/uniprot/Q29ZP1|||http://purl.uniprot.org/uniprot/Q29ZP6|||http://purl.uniprot.org/uniprot/Q29ZP7|||http://purl.uniprot.org/uniprot/Q9BGS7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion (By similarity).|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/9541:NEK7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPW1|||http://purl.uniprot.org/uniprot/G7NWH7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:TPST2 ^@ http://purl.uniprot.org/uniprot/G7PHG0|||http://purl.uniprot.org/uniprot/Q4R863 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane|||Homodimer. Can also form heterodimers with TPST1.|||N-glycosylated.|||Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft. http://togogenome.org/gene/9541:GLYCTK ^@ http://purl.uniprot.org/uniprot/A0A2K5V6G9 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/9541:EXOC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TMF7 ^@ Similarity ^@ Belongs to the SEC10 family. http://togogenome.org/gene/9541:BMP4 ^@ http://purl.uniprot.org/uniprot/A0A7N9I9M4 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:HYI ^@ http://purl.uniprot.org/uniprot/A0A2K5VFE9|||http://purl.uniprot.org/uniprot/A0A2K5VFF2 ^@ Function|||Similarity ^@ Belongs to the hyi family.|||Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). http://togogenome.org/gene/9541:UGT3A2 ^@ http://purl.uniprot.org/uniprot/A0A7G0UDE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:TXLNG ^@ http://purl.uniprot.org/uniprot/G7Q2B0 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/9541:LOC102144405 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Y3 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9541:LZTFL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/9541:PAGE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVI5 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:CD9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/9541:GABRB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YGX5|||http://purl.uniprot.org/uniprot/G7P5I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:CSRNP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPS8|||http://purl.uniprot.org/uniprot/G7PIB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/9541:LOXL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X388 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/9541:LOC107126435 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y118|||http://purl.uniprot.org/uniprot/G7Q164 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/9541:LOC102136805 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:NUDT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA83 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. PCD1 subfamily. http://togogenome.org/gene/9541:SLC19A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||High-affinity transporter for the intake of thiamine. http://togogenome.org/gene/9541:PAX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLQ1|||http://purl.uniprot.org/uniprot/A0A2K5VM65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4W1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MBOAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC7A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TND9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ZNF24 ^@ http://purl.uniprot.org/uniprot/A0A2K5URW2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CHAC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHG6 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/9541:ELP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAP6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/9541:PA2G4 ^@ http://purl.uniprot.org/uniprot/I7GJ62 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/9541:ASIC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDU9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102120517 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9L4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/9541:HMGN2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAJ5|||http://purl.uniprot.org/uniprot/G7NXM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:SNAP91 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVQ7|||http://purl.uniprot.org/uniprot/A0A2K5VVV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PICALM/SNAP91 family.|||Membrane http://togogenome.org/gene/9541:CDC25C ^@ http://purl.uniprot.org/uniprot/A0A2K5V9Q2|||http://purl.uniprot.org/uniprot/Q4R6H0 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/9541:KCNK10 ^@ http://purl.uniprot.org/uniprot/A0A2K5W234|||http://purl.uniprot.org/uniprot/A0A8J8YKE1|||http://purl.uniprot.org/uniprot/G7PB47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:LOC102117828 ^@ http://purl.uniprot.org/uniprot/G7PCH4|||http://purl.uniprot.org/uniprot/Q4R5B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:G6PD ^@ http://purl.uniprot.org/uniprot/A0A7N9CPQ8 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. http://togogenome.org/gene/9541:CRYGB ^@ http://purl.uniprot.org/uniprot/A0A2K5VQC7 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:KPNA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX73 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/9541:HNF4A ^@ http://purl.uniprot.org/uniprot/A0A2K5VA24|||http://purl.uniprot.org/uniprot/A0A2K5VA29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/9541:TMEM225 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYG3|||http://purl.uniprot.org/uniprot/G7PPD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SNRPB ^@ http://purl.uniprot.org/uniprot/A0A2K5WP22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/9541:ENO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5URN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/9541:SNX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||phagosome http://togogenome.org/gene/9541:LGR5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102138266 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZK6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:ECI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTJ3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:RPS10 ^@ http://purl.uniprot.org/uniprot/I7G299 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/9541:NRN1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CHF2 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/9541:PACSIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/9541:SAG ^@ http://purl.uniprot.org/uniprot/A0A2K5VU20 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/9541:LOC102123393 ^@ http://purl.uniprot.org/uniprot/Q25MM9|||http://purl.uniprot.org/uniprot/Q4R4I0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).|||Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12. Interacts with TERF2; the interaction is direct (By similarity).|||Belongs to the RAP1 family.|||Chromosome|||Cytoplasm|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/9541:STAG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/9541:AP2M1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQ19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||coated pit http://togogenome.org/gene/9541:TLE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9541:RRM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCP7|||http://purl.uniprot.org/uniprot/G7PQZ6 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/9541:PCOLCE2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7D8|||http://purl.uniprot.org/uniprot/G7P007 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:LOC102118714 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIT1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/9541:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQH9|||http://purl.uniprot.org/uniprot/G7PTW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BACURD family.|||Cell membrane http://togogenome.org/gene/9541:CERS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VI72 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/9541:UTS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/9541:MYF5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGL2|||http://purl.uniprot.org/uniprot/G7PIK2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/9541:LOC102143906 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSH4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ZC3H14 ^@ http://purl.uniprot.org/uniprot/Q4R6F6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZC3H14 family.|||Interacts with HOOK2. Interacts with ZFC3H1 in a RNase-sensitive manner.|||Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.|||Nucleus speckle http://togogenome.org/gene/9541:RBM15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN70 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/9541:MED28 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 28 family.|||Nucleus http://togogenome.org/gene/9541:LIN7A ^@ http://purl.uniprot.org/uniprot/A0A2K5X044 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/9541:MST1R ^@ http://purl.uniprot.org/uniprot/A0A2K5VT07 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:XPOT ^@ http://purl.uniprot.org/uniprot/A0A2K5V425 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/9541:LOC107127356 ^@ http://purl.uniprot.org/uniprot/G7PQ69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:AQP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:USP13 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6N7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:ADGRG7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8Z4|||http://purl.uniprot.org/uniprot/A0A2K5X9E2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SETDB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZX6 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/9541:NAV3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VM19 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/9541:SLCO6A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXZ1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:FITM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMP8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SMAD4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZF7|||http://purl.uniprot.org/uniprot/G7PWS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SLC17A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U213 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ASRGL1 ^@ http://purl.uniprot.org/uniprot/G7PPU6|||http://purl.uniprot.org/uniprot/Q4R7U8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Ntn-hydrolase family.|||Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.|||Cytoplasm|||Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.|||Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer. http://togogenome.org/gene/9541:MRTO4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V748 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/9541:TAF9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VD20|||http://purl.uniprot.org/uniprot/A0A8J8Y5T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/9541:POP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/9541:HSPD1 ^@ http://purl.uniprot.org/uniprot/I7G496 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/9541:ACP2 ^@ http://purl.uniprot.org/uniprot/Q4R5N9 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family.|||Lysosome lumen|||Lysosome membrane|||The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen (By similarity). http://togogenome.org/gene/9541:POLR2B ^@ http://purl.uniprot.org/uniprot/A0A2K5VZA8 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/9541:MTMR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IAS5|||http://purl.uniprot.org/uniprot/A0A8J8XPP1|||http://purl.uniprot.org/uniprot/G7PNI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/9541:TAFA1 ^@ http://purl.uniprot.org/uniprot/I7GMV7 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9541:LSM14A ^@ http://purl.uniprot.org/uniprot/A0A2K5UDC8 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/9541:LOC102144707 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CDCA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TND4|||http://purl.uniprot.org/uniprot/A0A2K5TND6|||http://purl.uniprot.org/uniprot/A0A8J8XQ54 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PPDPF ^@ http://purl.uniprot.org/uniprot/A0A2K5X4I8 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9541:STAR ^@ http://purl.uniprot.org/uniprot/A0A2K5UU11 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/9541:HMBS ^@ http://purl.uniprot.org/uniprot/G7PP48 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/9541:MED11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/9541:DNAJB12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFF1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:NONO ^@ http://purl.uniprot.org/uniprot/A0A2K5WWT3 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9541:TMEM35B ^@ http://purl.uniprot.org/uniprot/A0A2K5WKY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/9541:ELF3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YH53|||http://purl.uniprot.org/uniprot/G7NWE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:FGGY ^@ http://purl.uniprot.org/uniprot/A0A2K5WK13 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/9541:STT3A ^@ http://purl.uniprot.org/uniprot/A0A8J8XKB3|||http://purl.uniprot.org/uniprot/G7PPM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/9541:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A2K5UBW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PMP22 ^@ http://purl.uniprot.org/uniprot/A0A2K5VV49 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Might be involved in growth regulation, and in myelinization in the peripheral nervous system. http://togogenome.org/gene/9541:SPSB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYN2 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9541:FOXP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X233 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ACVR2A ^@ http://purl.uniprot.org/uniprot/A0A7N9IF81|||http://purl.uniprot.org/uniprot/A0A8J8XY46|||http://purl.uniprot.org/uniprot/G7PKJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/9541:PCNX1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/9541:NIPAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBH5|||http://purl.uniprot.org/uniprot/A0A8J8XE03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/9541:CKM ^@ http://purl.uniprot.org/uniprot/A0A2K5WCT8 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/9541:LOC102139144 ^@ http://purl.uniprot.org/uniprot/G7P2Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RPS6 ^@ http://purl.uniprot.org/uniprot/Q4R4K6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS6 family.|||Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.|||Component of the small ribosomal subunit.|||Cytoplasm|||Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation.|||Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex.|||Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8. http://togogenome.org/gene/9541:DCP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXJ7|||http://purl.uniprot.org/uniprot/A0A2K5WXS4 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/9541:FAM53C ^@ http://purl.uniprot.org/uniprot/A0A8J8XQE5|||http://purl.uniprot.org/uniprot/G7P8E1 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/9541:COPS5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YCP6|||http://purl.uniprot.org/uniprot/G7PBZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/9541:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDW4 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/9541:ADCY8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9541:RPL6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0H8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/9541:ELL ^@ http://purl.uniprot.org/uniprot/A0A2K5VPN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Nucleus http://togogenome.org/gene/9541:RPS15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXU9|||http://purl.uniprot.org/uniprot/A0A7N9ICI6 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS19 family.|||Component of the small ribosomal subunit. http://togogenome.org/gene/9541:LOC102138871 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:CCL18 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:TPRA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCA6|||http://purl.uniprot.org/uniprot/G7PJ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/9541:CLEC12B ^@ http://purl.uniprot.org/uniprot/A0A2K5TTK1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:ACOT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY94|||http://purl.uniprot.org/uniprot/A0A2K5UYC4 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9541:TLCD3A ^@ http://purl.uniprot.org/uniprot/A0A2K5TJW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102137365 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF51 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SLC1A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9541:CACNA1S ^@ http://purl.uniprot.org/uniprot/A0A8J8XWF9|||http://purl.uniprot.org/uniprot/G7NWG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/9541:FAM221A ^@ http://purl.uniprot.org/uniprot/A0A2K5WRE7 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/9541:CPLX1 ^@ http://purl.uniprot.org/uniprot/Q4R4N1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complexin/synaphin family.|||Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.|||Perikaryon|||Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).|||Presynapse|||cytosol http://togogenome.org/gene/9541:ERG ^@ http://purl.uniprot.org/uniprot/A0A2K5UZM9|||http://purl.uniprot.org/uniprot/A0A2K5UZU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:PLD3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQT5|||http://purl.uniprot.org/uniprot/G7PXL5 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9541:IGF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URR6|||http://purl.uniprot.org/uniprot/A0A2K5URS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9541:LANCL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D691 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/9541:NAA10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKW9 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/9541:XPO4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Nucleus http://togogenome.org/gene/9541:DAO ^@ http://purl.uniprot.org/uniprot/A0A2K5UAL0|||http://purl.uniprot.org/uniprot/A0A7N9I9P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/9541:PHTF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TMEM9B ^@ http://purl.uniprot.org/uniprot/A0A7N9CG06|||http://purl.uniprot.org/uniprot/A0A7N9D7R0 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/9541:MED24 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/9541:CENPS ^@ http://purl.uniprot.org/uniprot/A0A7N9D2J9 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/9541:TMEM88 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4M8|||http://purl.uniprot.org/uniprot/G7PTJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM88 family.|||Membrane http://togogenome.org/gene/9541:LOC102132836 ^@ http://purl.uniprot.org/uniprot/A0A7N9CSE3 ^@ Similarity ^@ Belongs to the pro/parathymosin family. http://togogenome.org/gene/9541:RPS19 ^@ http://purl.uniprot.org/uniprot/Q25PV7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/9541:TSC22D3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6V2|||http://purl.uniprot.org/uniprot/A0A8J8Y7S0|||http://purl.uniprot.org/uniprot/G7Q3E9 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/9541:TRIM38 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDM0|||http://purl.uniprot.org/uniprot/G7P2K9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:FIGN ^@ http://purl.uniprot.org/uniprot/A0A2K5WYQ8|||http://purl.uniprot.org/uniprot/A0A8J8XP02 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/9541:ERO1A ^@ http://purl.uniprot.org/uniprot/A0A2K5UA33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:LOC107126403 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/9541:GTF2H5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJD9|||http://purl.uniprot.org/uniprot/G7P4W3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/9541:SYNPR ^@ http://purl.uniprot.org/uniprot/A0A2K5X4L0|||http://purl.uniprot.org/uniprot/A0A2K5X4L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/9541:LOC101925870 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5W4|||http://purl.uniprot.org/uniprot/A0A8J8YP37 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/9541:ERBIN ^@ http://purl.uniprot.org/uniprot/A0A2K5V407|||http://purl.uniprot.org/uniprot/A0A2K5V423|||http://purl.uniprot.org/uniprot/A0A2K5V490 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9541:TGFB3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEN9|||http://purl.uniprot.org/uniprot/G7PB17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/9541:GALR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:LOC101925320 ^@ http://purl.uniprot.org/uniprot/Q4R8D3 ^@ Similarity ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. http://togogenome.org/gene/9541:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/9541:STX19 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDG1 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:CLDN9 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCC0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:EYA1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0Y3|||http://purl.uniprot.org/uniprot/G7PC08 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/9541:SGCE ^@ http://purl.uniprot.org/uniprot/I7G8Y1|||http://purl.uniprot.org/uniprot/Q4R5B1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Golgi apparatus|||N-glycosylated.|||Ubiquitinated, leading to its degradation by the proteasome.|||cytoskeleton|||dendrite|||sarcolemma http://togogenome.org/gene/9541:AQP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/9541:MRPS5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VG54 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/9541:HSD17B13 ^@ http://purl.uniprot.org/uniprot/A0A8J8YIB5|||http://purl.uniprot.org/uniprot/G7P5V3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:ELMO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQB0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9541:TGFBI ^@ http://purl.uniprot.org/uniprot/A0A7N9CID1 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9541:HAUS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/9541:ALKBH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W013 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9541:MYOZ1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTD3 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9541:PYGB ^@ http://purl.uniprot.org/uniprot/A0A2K5TPE2 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/9541:STMN3 ^@ http://purl.uniprot.org/uniprot/Q4R4N5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the stathmin family.|||Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.|||Golgi apparatus|||Interacts with STAT3. Interacts with CLU (secreted form); this interaction may act as an important modulator during neuronal differentiation (By similarity).|||N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).|||axon|||cytosol|||growth cone http://togogenome.org/gene/9541:FAM124B ^@ http://purl.uniprot.org/uniprot/A0A2K5UWB2 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/9541:LOC102123765 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHR3|||http://purl.uniprot.org/uniprot/G7PWP2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:ZDHHC20 ^@ http://purl.uniprot.org/uniprot/A0A7N9IEJ6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:PSENEN ^@ http://purl.uniprot.org/uniprot/A0A2K5U3R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:S100A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5X560 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:LHFPL6 ^@ http://purl.uniprot.org/uniprot/I7GNY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SNX13 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2F3 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9541:GML ^@ http://purl.uniprot.org/uniprot/A0A2K5TTQ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:MED7 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMB4|||http://purl.uniprot.org/uniprot/G7P6Q8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/9541:TMEM144 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHB4|||http://purl.uniprot.org/uniprot/G7P6H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/9541:SAE1 ^@ http://purl.uniprot.org/uniprot/I7GJM9 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/9541:HLF ^@ http://purl.uniprot.org/uniprot/A0A2K5V5N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/9541:SF3B3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTN4|||http://purl.uniprot.org/uniprot/G7Q1L4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:UBE2G2 ^@ http://purl.uniprot.org/uniprot/A0A7N9DD68 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:LYG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUM1|||http://purl.uniprot.org/uniprot/G8F441 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/9541:STOML1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUA5 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/9541:TFEC ^@ http://purl.uniprot.org/uniprot/A0A2K5VA00|||http://purl.uniprot.org/uniprot/A0A7N9CGQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/9541:ANO3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V2S6|||http://purl.uniprot.org/uniprot/A0A2K5V2T9|||http://purl.uniprot.org/uniprot/A0A7N9DAE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PCLAF ^@ http://purl.uniprot.org/uniprot/A0A2K5X752 ^@ Subcellular Location Annotation ^@ Nucleus|||perinuclear region http://togogenome.org/gene/9541:LOC102115550 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:NTN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJR4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TBCB ^@ http://purl.uniprot.org/uniprot/I7GAX3 ^@ Similarity ^@ Belongs to the TBCB family. http://togogenome.org/gene/9541:PAQR7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7E0|||http://purl.uniprot.org/uniprot/G7NVX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:SLC26A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9541:CXCR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV19 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homomer. Forms heteromers with ACKR4.|||Membrane http://togogenome.org/gene/9541:ADA ^@ http://purl.uniprot.org/uniprot/A0A2K5VY31|||http://purl.uniprot.org/uniprot/A0A7N9DHL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Cell junction|||Cell membrane|||Cytoplasmic vesicle lumen http://togogenome.org/gene/9541:MRPS7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y331|||http://purl.uniprot.org/uniprot/G7PVD9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9541:KRT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4I5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:ERP29 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDP8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Does not seem to be a disulfide isomerase.|||Endoplasmic reticulum lumen|||Homodimer.|||Melanosome http://togogenome.org/gene/9541:SNX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXX6|||http://purl.uniprot.org/uniprot/A0A7N9C732 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/9541:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A2K5U1X8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/9541:CDK2AP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V6H8|||http://purl.uniprot.org/uniprot/A0A7N9CEQ4|||http://purl.uniprot.org/uniprot/G8F6F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDK2AP family.|||Nucleus http://togogenome.org/gene/9541:BZW2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1J4|||http://purl.uniprot.org/uniprot/G7P0T4 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/9541:SULT2A1 ^@ http://purl.uniprot.org/uniprot/P52842 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the sulfotransferase 1 family.|||Homodimer.|||Predominanly expressed in liver. Detected also in adrenal gland and in jejunum.|||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:31100221). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).|||cytosol http://togogenome.org/gene/9541:MOV10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/9541:RRH ^@ http://purl.uniprot.org/uniprot/A0A8J8XE25|||http://purl.uniprot.org/uniprot/G7P633 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/9541:SLC35A4 ^@ http://purl.uniprot.org/uniprot/G7P8G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:RANBP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBP7 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/9541:LOC102146388 ^@ http://purl.uniprot.org/uniprot/G7PZ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ANXA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSU0|||http://purl.uniprot.org/uniprot/A0A8J8XPJ1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/9541:DCAF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat LEC14B family.|||Interacts with DDB1 and CUL4A.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/9541:MKS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y989|||http://purl.uniprot.org/uniprot/G7PUF5 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/9541:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULK0|||http://purl.uniprot.org/uniprot/A0A8J8Y7D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9541:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLY7|||http://purl.uniprot.org/uniprot/G7NV38 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9541:RPS27A ^@ http://purl.uniprot.org/uniprot/Q4R580 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/9541:SKIV2L ^@ http://purl.uniprot.org/uniprot/A0A2K5WFV6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:CCL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y905|||http://purl.uniprot.org/uniprot/G7PU26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:CUL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VN06 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:CA5A ^@ http://purl.uniprot.org/uniprot/A0A7N9CDB0 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:CYSLTR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CNM6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:TOE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZM3 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/9541:VAPA ^@ http://purl.uniprot.org/uniprot/A0A2K5VVK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:DPH6 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4G7|||http://purl.uniprot.org/uniprot/G7PAQ2 ^@ Function|||Similarity ^@ Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.|||Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/9541:B3GALT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:IL21 ^@ http://purl.uniprot.org/uniprot/A0A2K5UL71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/9541:TAS2R39 ^@ http://purl.uniprot.org/uniprot/A0A7N9CZT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:RRP12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXV4 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/9541:LOC102127089 ^@ http://purl.uniprot.org/uniprot/G7P2B4 ^@ Similarity ^@ Belongs to the CFAP144 family. http://togogenome.org/gene/9541:TMEM258 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/9541:KDM3A ^@ http://purl.uniprot.org/uniprot/A0A2K5WSI1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM2 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.|||Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.|||Nucleus|||The JmjC domain and the C6-type zinc-finger are required for the demethylation activity. http://togogenome.org/gene/9541:EMC2 ^@ http://purl.uniprot.org/uniprot/G7PCI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/9541:MRPS33 ^@ http://purl.uniprot.org/uniprot/A0A8J8YM69|||http://purl.uniprot.org/uniprot/G7P1E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/9541:HMGCR ^@ http://purl.uniprot.org/uniprot/A0A2K5U695|||http://purl.uniprot.org/uniprot/A0A7N9CZC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/9541:ABHD2 ^@ http://purl.uniprot.org/uniprot/G7P9E4|||http://purl.uniprot.org/uniprot/Q4R2Y9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Acylglycerol lipase activity is activated upon binding to progesterone.|||Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.|||Cell membrane|||Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). May also play a role in smooth muscle cells migration (By similarity). http://togogenome.org/gene/9541:CCDC90B ^@ http://purl.uniprot.org/uniprot/A0A2K5WFP1|||http://purl.uniprot.org/uniprot/A0A2K5WFQ9 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/9541:TRIM45 ^@ http://purl.uniprot.org/uniprot/A0A2K5X306 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/9541:FOLR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U044 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9541:NSUN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/9541:DOK6 ^@ http://purl.uniprot.org/uniprot/A0A7N9CHL0 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9541:FAM3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VW74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9541:SLC11A2 ^@ http://purl.uniprot.org/uniprot/Q9MZV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAMP family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9541:WDR48 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW67|||http://purl.uniprot.org/uniprot/A0A2K5VWB3|||http://purl.uniprot.org/uniprot/G7NYJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Late endosome http://togogenome.org/gene/9541:VPS54 ^@ http://purl.uniprot.org/uniprot/A0A2K5W0T5|||http://purl.uniprot.org/uniprot/A0A8J8Y6W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/9541:PFN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGF2 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/9541:SLC29A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL78|||http://purl.uniprot.org/uniprot/G7P406 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9541:CDK5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYL9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:PHGDH ^@ http://purl.uniprot.org/uniprot/A0A158SIP3|||http://purl.uniprot.org/uniprot/Q60HD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.|||Homotetramer. http://togogenome.org/gene/9541:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/9541:CLDN8 ^@ http://purl.uniprot.org/uniprot/G7P1L5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:LOC102130191 ^@ http://purl.uniprot.org/uniprot/A0A2K5W618 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/9541:ACAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9T2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/9541:ZIC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKM4 ^@ Similarity ^@ Belongs to the GLI C2H2-type zinc-finger protein family. http://togogenome.org/gene/9541:PLD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7U5 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/9541:OLFM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0Y2 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/9541:CCL26 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:CHL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5I6|||http://purl.uniprot.org/uniprot/A0A2K5U5L5|||http://purl.uniprot.org/uniprot/A0A2K5U5M5 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. http://togogenome.org/gene/9541:MFAP5 ^@ http://purl.uniprot.org/uniprot/A0A7N9ICY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/9541:SMC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:SMPX ^@ http://purl.uniprot.org/uniprot/A0A8J8YPK5|||http://purl.uniprot.org/uniprot/G7Q2C8 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/9541:LOC102120872 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIV2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:ANXA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W030 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/9541:ADD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2Z1|||http://purl.uniprot.org/uniprot/A0A2K5U319|||http://purl.uniprot.org/uniprot/A0A2K5U342|||http://purl.uniprot.org/uniprot/A0A7N9CQE1 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/9541:RNASE4 ^@ http://purl.uniprot.org/uniprot/G7P9M0 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:SNX33 ^@ http://purl.uniprot.org/uniprot/A0A2K5TY56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/9541:LOC102134759 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2I4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC102122852 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAJ5|||http://purl.uniprot.org/uniprot/G7NXM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:TPPP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5USV3 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/9541:JAGN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLU3|||http://purl.uniprot.org/uniprot/G8F652 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:WNT16 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVE2|||http://purl.uniprot.org/uniprot/A0A8J8YBR9|||http://purl.uniprot.org/uniprot/G7P0J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:PANX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA54 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/9541:MRPL50 ^@ http://purl.uniprot.org/uniprot/A0A7N9D744 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/9541:RARB ^@ http://purl.uniprot.org/uniprot/A0A2K5WS97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC107129593 ^@ http://purl.uniprot.org/uniprot/A0A8U0WQ25|||http://purl.uniprot.org/uniprot/G8F3V0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:CLDN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJH5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:MTNR1A ^@ http://purl.uniprot.org/uniprot/C9WTA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9541:AK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0D6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9541:ERH ^@ http://purl.uniprot.org/uniprot/A0A2K5U2F3 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/9541:CD44 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIV5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/9541:NARF ^@ http://purl.uniprot.org/uniprot/A0A2K5W8L6|||http://purl.uniprot.org/uniprot/A0A2K5W8M3 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/9541:UXT ^@ http://purl.uniprot.org/uniprot/A0A2K5TZQ7 ^@ Similarity ^@ Belongs to the UXT family. http://togogenome.org/gene/9541:YWHAB ^@ http://purl.uniprot.org/uniprot/A0A158SIP8|||http://purl.uniprot.org/uniprot/Q4R572 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.|||Belongs to the 14-3-3 family.|||Cytoplasm|||Homodimer (By similarity). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2. Interacts with YAP1 (phosphorylated form). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with PKA-phosphorylated AANAT. Interacts with MYO1C. Interacts with SIRT2 (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (By similarity). Interacts with SLITRK1. Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form); this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with TESK1; the interaction is dependent on the phosphorylation of TESK1 'Ser-437' and inhibits TESK1 kinase activity (By similarity). Interacts with MEFV (By similarity). Interacts with HDAC4 (By similarity). Interacts with ADAM22 (via C-terminus) (By similarity).|||Inferred by similarity.|||Isoform Short contains a N-acetylmethionine at position 1.|||Melanosome|||The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. http://togogenome.org/gene/9541:RAB27A ^@ http://purl.uniprot.org/uniprot/A0A8J8XYX3|||http://purl.uniprot.org/uniprot/G7PBI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/9541:OSBPL11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPP6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/9541:CRKL ^@ http://purl.uniprot.org/uniprot/A0A8J8YEB0|||http://purl.uniprot.org/uniprot/G7PHA6 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/9541:UBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1K2|||http://purl.uniprot.org/uniprot/A0A2K5U1L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102130495 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAW2|||http://purl.uniprot.org/uniprot/G7P5Z7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SPC25 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF95|||http://purl.uniprot.org/uniprot/G7PKR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/9541:SPNS1 ^@ http://purl.uniprot.org/uniprot/G7Q0T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/9541:UBE2F ^@ http://purl.uniprot.org/uniprot/A0A2K5VBA5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:DNM1L ^@ http://purl.uniprot.org/uniprot/A0A2K5UCX1|||http://purl.uniprot.org/uniprot/A0A2K5UCX6|||http://purl.uniprot.org/uniprot/A0A2K5UD34 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/9541:SLC26A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WID5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/9541:SEMA3D ^@ http://purl.uniprot.org/uniprot/A0A2K5VQE5 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102143300 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH37 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/9541:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ72|||http://purl.uniprot.org/uniprot/G7PQP3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:SURF4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CUS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:BTG4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0K2 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:FBXO32 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1L4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SERPINB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTD0 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/9541:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VLE1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TAF11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAH3 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/9541:SLC25A35 ^@ http://purl.uniprot.org/uniprot/A0A7N9CM21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:FURIN ^@ http://purl.uniprot.org/uniprot/A0A2K5U5X5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/9541:CERCAM ^@ http://purl.uniprot.org/uniprot/A0A2K5TVP7 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/9541:TFCP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXR1|||http://purl.uniprot.org/uniprot/A0A7N9IEW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/9541:ARMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VA55 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/9541:REEP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/9541:FXYD6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U219|||http://purl.uniprot.org/uniprot/G7PP24 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9541:PEX16 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/9541:GPM6A ^@ http://purl.uniprot.org/uniprot/A0A2K5UTC4|||http://purl.uniprot.org/uniprot/A0A8J8XLU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/9541:PHAF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YPC1|||http://purl.uniprot.org/uniprot/G7Q1C4 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/9541:PIGC ^@ http://purl.uniprot.org/uniprot/A0A2K5UID7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/9541:CPNE3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVS8 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:VSNL1 ^@ http://purl.uniprot.org/uniprot/Q4R5F7 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the recoverin family.|||Probably binds three calcium ions.|||Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. http://togogenome.org/gene/9541:DARS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEA8 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/9541:CPNE5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2P2 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:TAC3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CCQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted http://togogenome.org/gene/9541:NGFR ^@ http://purl.uniprot.org/uniprot/A0A2K5VJS0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:NDST3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9541:SLC28A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/9541:TRMT13 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y3H0|||http://purl.uniprot.org/uniprot/G7NV26 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/9541:LOC101926276 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBJ9|||http://purl.uniprot.org/uniprot/G8F324 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH94|||http://purl.uniprot.org/uniprot/G7Q3N4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:DHX15 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB33 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. http://togogenome.org/gene/9541:AGK ^@ http://purl.uniprot.org/uniprot/A0A2K5WYW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:CAMK2G ^@ http://purl.uniprot.org/uniprot/I7GJL2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:CYP1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UT62|||http://purl.uniprot.org/uniprot/A0A7N9D2X8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:KEG98_p01 ^@ http://purl.uniprot.org/uniprot/C3W4Z7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. http://togogenome.org/gene/9541:TPPP2 ^@ http://purl.uniprot.org/uniprot/G7P9N0|||http://purl.uniprot.org/uniprot/Q4R3A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TPPP family.|||Probable regulator of microtubule dynamics required for sperm motility (By similarity). In contrast to other members of the family, has no microtubule bundling activity (By similarity).|||cytosol|||flagellum http://togogenome.org/gene/9541:MRPS21 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y104|||http://purl.uniprot.org/uniprot/G7NTS9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/9541:RAPSN ^@ http://purl.uniprot.org/uniprot/A0A2K5WJX9 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/9541:BCL7C ^@ http://purl.uniprot.org/uniprot/A0A2K5V193|||http://purl.uniprot.org/uniprot/A0A2K5V1A2 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/9541:SFRP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WND6|||http://purl.uniprot.org/uniprot/G8F2Z7 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102121157 ^@ http://purl.uniprot.org/uniprot/G7PQ24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NDUFS7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 20 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LOC102117187 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPR2|||http://purl.uniprot.org/uniprot/G7NTR4 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SLC25A30 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:LDHB ^@ http://purl.uniprot.org/uniprot/G7PCH4|||http://purl.uniprot.org/uniprot/Q4R5B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SLC1A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/9541:PSEN1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDD5|||http://purl.uniprot.org/uniprot/G7PAT1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/9541:LOC102130617 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX78|||http://purl.uniprot.org/uniprot/A0A8J8XVQ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/9541:MAN1B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1J4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9541:FOXP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X941 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GPRC5D ^@ http://purl.uniprot.org/uniprot/A0A2K5W6I7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:FAXDC2 ^@ http://purl.uniprot.org/uniprot/Q9GKT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family.|||Cytoplasm|||Membrane|||Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. http://togogenome.org/gene/9541:TGFBR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD61|||http://purl.uniprot.org/uniprot/A0A2K5WD91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/9541:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/G7PH54|||http://purl.uniprot.org/uniprot/Q4R532 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CD225/Dispanin family.|||Cell membrane|||Early endosome membrane|||Homodimer. Interacts with GRIA1 and GRIA2 (By similarity).|||May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.|||Postsynaptic density membrane|||Synapse|||dendrite|||dendritic spine http://togogenome.org/gene/9541:DNAJC24 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDF8 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/9541:TMEM251 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LYSET family.|||Membrane http://togogenome.org/gene/9541:GPHB5 ^@ http://purl.uniprot.org/uniprot/A0A7N9IDV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/9541:SLC44A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/9541:MMGT1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4Z9|||http://purl.uniprot.org/uniprot/G7Q1S3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/9541:S100A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.|||Nucleus envelope http://togogenome.org/gene/9541:TOM1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IGN3|||http://purl.uniprot.org/uniprot/G7PFA5 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9541:TCEA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW82|||http://purl.uniprot.org/uniprot/A0A2K5VWA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/9541:SLC12A3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XK92|||http://purl.uniprot.org/uniprot/G7Q167 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:TDRD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE00|||http://purl.uniprot.org/uniprot/G8F2W0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:HM13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/9541:HDDC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAF6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/9541:FOXN3 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQQ7|||http://purl.uniprot.org/uniprot/A0A7N9D9G0 ^@ Function|||Subcellular Location Annotation ^@ Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|||Nucleus http://togogenome.org/gene/9541:LOC102118330 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQP4|||http://purl.uniprot.org/uniprot/G7P2L5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:KCTD17 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7C5|||http://purl.uniprot.org/uniprot/A0A2K5W7E2|||http://purl.uniprot.org/uniprot/A0A2K5W7I0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:LOC102136972 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX78|||http://purl.uniprot.org/uniprot/A0A8J8XVQ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/9541:C3AR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/9541:MKX ^@ http://purl.uniprot.org/uniprot/A0A7N9IFI3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ANXA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHK9 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9541:SPTSSA ^@ http://purl.uniprot.org/uniprot/I7GMV0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PFDN5 ^@ http://purl.uniprot.org/uniprot/G7PHU6 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/9541:CPLX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9541:PPP2R5C ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ49 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9541:PPP3CC ^@ http://purl.uniprot.org/uniprot/A0A2K5UDC3 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9541:EXOC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMY4 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/9541:LHX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0E1|||http://purl.uniprot.org/uniprot/A0A2K5X0F0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ASB12 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y3T4|||http://purl.uniprot.org/uniprot/G7Q2W5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4N2|||http://purl.uniprot.org/uniprot/A0A2K5V4N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9541:NELL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1B5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GET1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PDCL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXR2 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9541:CDH9 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8N6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PDCL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7V0 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/9541:CMC2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBQ7|||http://purl.uniprot.org/uniprot/G7PZT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/9541:PSMB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8G9|||http://purl.uniprot.org/uniprot/G8F2D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/9541:IMP4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CN51 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/9541:DNPH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.|||Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.|||Cytoplasm|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/9541:MAK16 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUL8 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/9541:YPEL5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEH2|||http://purl.uniprot.org/uniprot/I7G2D8 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/9541:MGST2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAJ7|||http://purl.uniprot.org/uniprot/G7P6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:XCR1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJL1|||http://purl.uniprot.org/uniprot/G7NY37 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:NTS ^@ http://purl.uniprot.org/uniprot/A0A8J8XFV0|||http://purl.uniprot.org/uniprot/G7PIL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/9541:TMEM17 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHF4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ARFGEF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5URX1 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/9541:TBX10 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDB5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:FADS2 ^@ http://purl.uniprot.org/uniprot/G7PPX1|||http://purl.uniprot.org/uniprot/Q4R749 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Endoplasmic reticulum membrane|||Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity).|||Membrane|||The protein sequence includes a number of characteristic features of microsomal fatty acid desaturases including the three histidine boxes HXXXH, HXXHH, and QXXHH (these domains may contain the active site and/or be involved in metal ion binding), and the N-terminal cytochrome b5 domain containing the heme-binding motif, HPGG, similar to that of other fatty acid desaturases. http://togogenome.org/gene/9541:TMSB10 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9541:LOC102122713 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/9541:SLC66A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFX7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LOC102138382 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNQ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:SPTY2D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKW5 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/9541:ABLIM3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ57 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:MAT2A ^@ http://purl.uniprot.org/uniprot/Q4R924 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. http://togogenome.org/gene/9541:CREB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X539|||http://purl.uniprot.org/uniprot/A0A7N9D5Y5|||http://purl.uniprot.org/uniprot/A0A8J8XE04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TAFA4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D012|||http://purl.uniprot.org/uniprot/Q9N0D3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAFA family.|||Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release.|||Secreted http://togogenome.org/gene/9541:SAR1B ^@ http://purl.uniprot.org/uniprot/A0A2K5W6R3 ^@ Similarity ^@ Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/9541:RRAGB ^@ http://purl.uniprot.org/uniprot/A0A2K5VWB6|||http://purl.uniprot.org/uniprot/A0A8J8Y3S3|||http://purl.uniprot.org/uniprot/G7Q2V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/9541:SUOX ^@ http://purl.uniprot.org/uniprot/A0A2K5WYK3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.|||Homodimer.|||Mitochondrion intermembrane space http://togogenome.org/gene/9541:LOC102136892 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF44|||http://purl.uniprot.org/uniprot/G7P6V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:SFN ^@ http://purl.uniprot.org/uniprot/A0A2K5UH26 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:CCL7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:PKM ^@ http://purl.uniprot.org/uniprot/A0A2K5VNC3|||http://purl.uniprot.org/uniprot/I7GH00 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/9541:LOC102123184 ^@ http://purl.uniprot.org/uniprot/G7P9M6 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:GRAMD1A ^@ http://purl.uniprot.org/uniprot/A0A2K5V6W0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PAQR3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X979|||http://purl.uniprot.org/uniprot/A0A2K5X986 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:NDUFB8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:DDX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULU9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/9541:HIF1A ^@ http://purl.uniprot.org/uniprot/Q4R658 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle http://togogenome.org/gene/9541:LOC102140409 ^@ http://purl.uniprot.org/uniprot/A0A7N9D912 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ASF1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VLV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/9541:GABRA1 ^@ http://purl.uniprot.org/uniprot/G7P6T7|||http://purl.uniprot.org/uniprot/Q4R534 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by benzodiazepines, the neuroanesthetic alphaxalone and pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity).|||Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Glycosylated.|||Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Interacts with UBQLN1 (By similarity). Interacts with TRAK1 (By similarity). Interacts with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4 (By similarity). Interacts with NLGN2 (By similarity). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (By similarity).|||Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The extracellular domain contributes to synaptic contact formation. http://togogenome.org/gene/9541:BEX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UHM0 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9541:BMP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0V5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:CTNND2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL88 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9541:ECSIT ^@ http://purl.uniprot.org/uniprot/Q4R5Q4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (By similarity). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity).|||As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the ECSIT family.|||Cytoplasm|||Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly/MCIA complex that comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits such as COA1 and TMEM186. Interacts with NDUFAF1. Interacts with ACAD9. Interacts with TRIM59. Interacts with TMEM70 and TMEM242. Interacts (when ubiquitinated) with NF-kappa-B subunits RELA and NFKB1. Interacts with RIGI, IFIT1 and MAVS; these interactions promote RLR-mediated type I IFN induction. Interacts with SQSTM1; this interaction inhibits TLR4 signaling via functional regulation of the TRAF6-ECSIT complex. Interacts with cereblon/CRBN; this interaction inhibits the ubiquitination of ECSIT (By similarity).|||Mitochondrion|||Nucleus|||Ubiquitinated on Lys-372; leading to translocation in the nucleus together with RELA and NFKB1 and expression of NF-kappa-B-dependent genes. http://togogenome.org/gene/9541:BANF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102143000 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5C1|||http://purl.uniprot.org/uniprot/G7PMS9 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/9541:PELI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC28 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/9541:UBL4A ^@ http://purl.uniprot.org/uniprot/A0A7N9CJ55 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/9541:OTUB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJQ2 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9541:PPEF1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5I8|||http://purl.uniprot.org/uniprot/Q4R4Y0 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/9541:LCE3A ^@ http://purl.uniprot.org/uniprot/G8F3F0 ^@ Similarity ^@ Belongs to the LCE family. http://togogenome.org/gene/9541:INS ^@ http://purl.uniprot.org/uniprot/P30406 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/9541:GNB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWG1 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/9541:CDIPT ^@ http://purl.uniprot.org/uniprot/A0A2K5WDN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/9541:SERPINB11 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y381|||http://purl.uniprot.org/uniprot/G7PWX7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:LCMT1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIE3|||http://purl.uniprot.org/uniprot/A0A7N9IAE8 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/9541:SLCO4C1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:WNT2B ^@ http://purl.uniprot.org/uniprot/A0A2K5TYW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:TMEM53 ^@ http://purl.uniprot.org/uniprot/A0A8J8XIR8|||http://purl.uniprot.org/uniprot/G7NUY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/9541:LOC102127018 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF72|||http://purl.uniprot.org/uniprot/G7P653 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/9541:TFAP2A ^@ http://purl.uniprot.org/uniprot/A0A2K5WXI6|||http://purl.uniprot.org/uniprot/A0A2K5WXM2|||http://purl.uniprot.org/uniprot/A0A2K5WY51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AP-2 family.|||Nucleus http://togogenome.org/gene/9541:SLC25A34 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:MAN2A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9X7 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/9541:TAGLN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ75 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/9541:LPCAT3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2P3|||http://purl.uniprot.org/uniprot/G7PJP3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TMEM230 ^@ http://purl.uniprot.org/uniprot/A0A7N9D152|||http://purl.uniprot.org/uniprot/I7GDG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/9541:LOC102118946 ^@ http://purl.uniprot.org/uniprot/A0A7N9DA28|||http://purl.uniprot.org/uniprot/Q95K74 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation.|||Membrane|||O-glycosylation at Thr-140 is essential for recognition by PILRA. http://togogenome.org/gene/9541:GREM2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CTP7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/9541:TRIM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5W6 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/9541:TPH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAQ7 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/9541:ALX4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXF7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:WNT11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VEE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/9541:LOC102122677 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PLA2G1B ^@ http://purl.uniprot.org/uniprot/A0A7N9IEX0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/9541:NDUFB2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CLV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:HEXIM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQK1|||http://purl.uniprot.org/uniprot/G7PV17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/9541:TMEM184B ^@ http://purl.uniprot.org/uniprot/A0A7N9D347|||http://purl.uniprot.org/uniprot/A0A8J8YHY8|||http://purl.uniprot.org/uniprot/G7PFF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ECH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDI1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/9541:CPN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDJ6 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/9541:DLGAP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1F4|||http://purl.uniprot.org/uniprot/A0A2K5V1M5 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/9541:SCPEP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR63|||http://purl.uniprot.org/uniprot/A0A8J8XDD6 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/9541:IMMT ^@ http://purl.uniprot.org/uniprot/A0A2K5VP54|||http://purl.uniprot.org/uniprot/A0A2K5VPB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:MYH3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD03 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:BEST1 ^@ http://purl.uniprot.org/uniprot/Q6UY87 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Basolateral cell membrane|||Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity).|||Phosphorylated by PP2A.|||Tetramer or pentamers. May interact with PPP2CB and PPP2R1B (By similarity). http://togogenome.org/gene/9541:ETFRF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1B3 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9541:TAF1D ^@ http://purl.uniprot.org/uniprot/A0A2K5X2F2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/9541:CDK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPV1|||http://purl.uniprot.org/uniprot/A0A2K5VPW1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:LOC102125774 ^@ http://purl.uniprot.org/uniprot/G7NUF9 ^@ Similarity ^@ Belongs to the cornifin (SPRR) family. http://togogenome.org/gene/9541:PARP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XL21|||http://purl.uniprot.org/uniprot/G7NTV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Interacts (when auto-poly-ADP-ribosylated) with AIFM1.|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.|||This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. http://togogenome.org/gene/9541:ANAPC13 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ33|||http://purl.uniprot.org/uniprot/G7NXY2 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/9541:LOC102124073 ^@ http://purl.uniprot.org/uniprot/A0A2K5X506 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/9541:ATP6V1E2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFX9 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/9541:B4GALNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WET1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:EIF2D ^@ http://purl.uniprot.org/uniprot/A0A2K5U4Z6|||http://purl.uniprot.org/uniprot/A0A7N9CWY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF2D family.|||Cytoplasm|||Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. http://togogenome.org/gene/9541:APEX2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0B6|||http://purl.uniprot.org/uniprot/G7Q2U4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9541:BEND6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQ79 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TOB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTF8|||http://purl.uniprot.org/uniprot/G7PUB7 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:CLPX ^@ http://purl.uniprot.org/uniprot/A0A2K5V120|||http://purl.uniprot.org/uniprot/A0A2K5V141 ^@ Similarity ^@ Belongs to the ClpX chaperone family. http://togogenome.org/gene/9541:AVPI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGI2 ^@ Function ^@ May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. http://togogenome.org/gene/9541:SEC61A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:FAM168A ^@ http://purl.uniprot.org/uniprot/A0A2K5U445|||http://purl.uniprot.org/uniprot/A0A8J8XHB5|||http://purl.uniprot.org/uniprot/G7PN71 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9541:BEX3 ^@ http://purl.uniprot.org/uniprot/G7Q3C3 ^@ Similarity ^@ Belongs to the BEX family. http://togogenome.org/gene/9541:CNOT6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XS73|||http://purl.uniprot.org/uniprot/G7P737 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SLC24A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX63|||http://purl.uniprot.org/uniprot/A0A2K5UX84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/9541:COG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U426|||http://purl.uniprot.org/uniprot/A0A7N9CLA2|||http://purl.uniprot.org/uniprot/G8F2E0 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/9541:AURKB ^@ http://purl.uniprot.org/uniprot/A0A2K5WL61|||http://purl.uniprot.org/uniprot/G7PTK4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/9541:MIX23 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULX4|||http://purl.uniprot.org/uniprot/A0A2K5ULX6 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/9541:RIMKLA ^@ http://purl.uniprot.org/uniprot/A0A2K5VKU1 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/9541:APOO ^@ http://purl.uniprot.org/uniprot/A0A2K5X7S8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:NELL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAV9|||http://purl.uniprot.org/uniprot/A0A2K5VAZ1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:RIDA ^@ http://purl.uniprot.org/uniprot/A0A8J8YT39|||http://purl.uniprot.org/uniprot/G7PCA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.|||Peroxisome http://togogenome.org/gene/9541:HSPA2 ^@ http://purl.uniprot.org/uniprot/G7PAI9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/9541:ELMO2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2M8|||http://purl.uniprot.org/uniprot/G7PG35 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/9541:CCDC124 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC124 family.|||Midbody http://togogenome.org/gene/9541:CPLX2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJI6|||http://purl.uniprot.org/uniprot/I7GKG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/9541:THBS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WN13|||http://purl.uniprot.org/uniprot/A0A2K5WN65|||http://purl.uniprot.org/uniprot/A0A2K5WN70 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ATG9A ^@ http://purl.uniprot.org/uniprot/A0A8J8YEM8|||http://purl.uniprot.org/uniprot/G7PK41 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/9541:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZ39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PDE6D ^@ http://purl.uniprot.org/uniprot/A0A2K5W427|||http://purl.uniprot.org/uniprot/G7PKA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PDE6D/unc-119 family.|||Cytoplasmic vesicle membrane|||Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.|||Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.|||cilium basal body|||cytosol http://togogenome.org/gene/9541:GRM3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYC3|||http://purl.uniprot.org/uniprot/G7P1W4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/9541:CDH20 ^@ http://purl.uniprot.org/uniprot/A0A7N9IGY0|||http://purl.uniprot.org/uniprot/G7PWW3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RPL37 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBE1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/9541:RFTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NAA25 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY54 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/9541:MZT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQF6|||http://purl.uniprot.org/uniprot/A0A979HJT3 ^@ Function|||Similarity ^@ Belongs to the MOZART1 family.|||Required for gamma-tubulin complex recruitment to the centrosome. http://togogenome.org/gene/9541:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRE0|||http://purl.uniprot.org/uniprot/G7Q218 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9541:ARL5B ^@ http://purl.uniprot.org/uniprot/A0A7N9CLT2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:LOC102124317 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNH7|||http://purl.uniprot.org/uniprot/G7P2M2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:WDR24 ^@ http://purl.uniprot.org/uniprot/A0A2K5UV49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR24 family.|||Lysosome membrane http://togogenome.org/gene/9541:VLDLR ^@ http://purl.uniprot.org/uniprot/A0A2K5V335|||http://purl.uniprot.org/uniprot/A0A2K5V352 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:HAL ^@ http://purl.uniprot.org/uniprot/A0A2K5TSK1 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/9541:ORC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0V5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:OXSR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U411 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. http://togogenome.org/gene/9541:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2N5|||http://purl.uniprot.org/uniprot/A0A2K5X335 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SDF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X223 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Golgi apparatus lumen http://togogenome.org/gene/9541:LDHC ^@ http://purl.uniprot.org/uniprot/A0A2K5WD20 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/9541:GMPR ^@ http://purl.uniprot.org/uniprot/A0A2K5W3H2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/9541:TADA3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XXL9|||http://purl.uniprot.org/uniprot/G7NYU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/9541:KRT12 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZW2|||http://purl.uniprot.org/uniprot/G7PUQ0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:LOC102135406 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQK1 ^@ Function|||Similarity ^@ Belongs to the globin family.|||The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. http://togogenome.org/gene/9541:STK38L ^@ http://purl.uniprot.org/uniprot/A0A2K5USX8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:FGF4 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0H1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:SLC5A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:KRT8 ^@ http://purl.uniprot.org/uniprot/A0A7N9CB91 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:SULT2B1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YDJ6|||http://purl.uniprot.org/uniprot/G7PY24 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:RPAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UY91|||http://purl.uniprot.org/uniprot/G8F395 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/9541:SIAH1 ^@ http://purl.uniprot.org/uniprot/G7Q129 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9541:GSS ^@ http://purl.uniprot.org/uniprot/A0A8J8XKD1|||http://purl.uniprot.org/uniprot/I7GA31 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/9541:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJ23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/9541:PGF ^@ http://purl.uniprot.org/uniprot/A0A2K5VMQ8 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/9541:TFAP2D ^@ http://purl.uniprot.org/uniprot/A0A8J8YE07|||http://purl.uniprot.org/uniprot/G7P4U7 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/9541:DMAP1 ^@ http://purl.uniprot.org/uniprot/G7NUY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:PENK ^@ http://purl.uniprot.org/uniprot/A0A2K5UXG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Increases glutamate release in the striatum and decreases GABA concentration in the striatum.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/9541:DGCR6L ^@ http://purl.uniprot.org/uniprot/A0A2K5W0W4 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/9541:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UA62|||http://purl.uniprot.org/uniprot/A0A8J8YC76|||http://purl.uniprot.org/uniprot/G7PWB5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PIGV ^@ http://purl.uniprot.org/uniprot/A0A2K5WCU5|||http://purl.uniprot.org/uniprot/G8F2H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/9541:GPAT4 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCX4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9541:LOC102120479 ^@ http://purl.uniprot.org/uniprot/P61252 ^@ Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Cell membrane|||Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins (By similarity).|||Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Can form disulfide-bonded heterodimer with CD94 (By similarity). Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (By similarity).|||Is not capable of signal transduction by itself, but operates through the adapter protein HCST.|||Natural killer cells. http://togogenome.org/gene/9541:CLGN ^@ http://purl.uniprot.org/uniprot/A0A8J8YPA9|||http://purl.uniprot.org/uniprot/G7P6B4 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9541:CHRND ^@ http://purl.uniprot.org/uniprot/A0A2K5V3B3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:TEX10 ^@ http://purl.uniprot.org/uniprot/A0A8J8YD58|||http://purl.uniprot.org/uniprot/G7PRU3 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/9541:PTH ^@ http://purl.uniprot.org/uniprot/G7PQP2|||http://purl.uniprot.org/uniprot/Q9XT35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Interacts with PTH1R (via N-terminal extracellular domain).|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).|||PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.|||Secreted http://togogenome.org/gene/9541:PHTF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V766|||http://purl.uniprot.org/uniprot/A0A2K5V778 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V184 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/9541:NAB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X146|||http://purl.uniprot.org/uniprot/A0A7N9CY18 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/9541:SEMA4C ^@ http://purl.uniprot.org/uniprot/A0A2K5VV83 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:POLR3GL ^@ http://purl.uniprot.org/uniprot/A0A8J8YID9|||http://purl.uniprot.org/uniprot/G7NTQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9541:LOC102131775 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHK5 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9541:LOC102132001 ^@ http://purl.uniprot.org/uniprot/G7P2N0|||http://purl.uniprot.org/uniprot/Q4R362 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.|||Belongs to the histone H4 family.|||Butyrylation of histones marks active promoters and competes with histone acetylation.|||Chromosome|||Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.|||Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.|||Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).|||Nucleus|||Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).|||Sumoylated, which is associated with transcriptional repression.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (By similarity). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).|||Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage. http://togogenome.org/gene/9541:GDA ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Q6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/9541:GNAI3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIQ6 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:HINT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRF4 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9541:BMP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC70|||http://purl.uniprot.org/uniprot/G7PGY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/9541:TATDN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TT38|||http://purl.uniprot.org/uniprot/A0A2K5TT59 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/9541:BAX ^@ http://purl.uniprot.org/uniprot/A0A2K5V7Y8 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/9541:F2R ^@ http://purl.uniprot.org/uniprot/A0A2K5VPA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:NECTIN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEQ6|||http://purl.uniprot.org/uniprot/A0A2K5WES1|||http://purl.uniprot.org/uniprot/L0N6D9 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/9541:ADRA1A ^@ http://purl.uniprot.org/uniprot/A0A2K5US01|||http://purl.uniprot.org/uniprot/G7PCY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/9541:SSR1 ^@ http://purl.uniprot.org/uniprot/Q4R4P7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/9541:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ25|||http://purl.uniprot.org/uniprot/A0A2K5WZE6|||http://purl.uniprot.org/uniprot/A0A2K5WZE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:LOC102131151 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAI4 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9541:SLC35F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVI2|||http://purl.uniprot.org/uniprot/A0A7N9CJ66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/9541:NCALD ^@ http://purl.uniprot.org/uniprot/Q4R4N4 ^@ Function|||Similarity ^@ Belongs to the recoverin family.|||May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). http://togogenome.org/gene/9541:DNAAF6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJR1|||http://purl.uniprot.org/uniprot/G7Q3E5 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/9541:TIMM17B ^@ http://purl.uniprot.org/uniprot/A0A2K5UAM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:CAST ^@ http://purl.uniprot.org/uniprot/A0A2K5V7W1|||http://purl.uniprot.org/uniprot/A0A2K5V839 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/9541:ARSB ^@ http://purl.uniprot.org/uniprot/A0A2K5WDQ3 ^@ Similarity ^@ Belongs to the sulfatase family. http://togogenome.org/gene/9541:BRMS1L ^@ http://purl.uniprot.org/uniprot/A0A2K5WK40 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DCTPP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YLF7|||http://purl.uniprot.org/uniprot/G7Q0X6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/9541:SLC6A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WY93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/9541:CDH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCE0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:FOXI1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TAS2R7 ^@ http://purl.uniprot.org/uniprot/G7PJU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:DKK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dickkopf family.|||Secreted http://togogenome.org/gene/9541:FAM241B ^@ http://purl.uniprot.org/uniprot/A0A2K5V1N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM241 family.|||Membrane http://togogenome.org/gene/9541:PFDN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMI8|||http://purl.uniprot.org/uniprot/A0A7N9CDD8 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9541:RNF157 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAD3|||http://purl.uniprot.org/uniprot/A0A7N9IA45 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/9541:GPHA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDU0 ^@ Caution|||Similarity ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PADI1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFJ7|||http://purl.uniprot.org/uniprot/G7NUR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9541:SLC7A11 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHH6|||http://purl.uniprot.org/uniprot/G7P6A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:UBE2D2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBG0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/9541:INTS10 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2N7|||http://purl.uniprot.org/uniprot/A0A2K5X373 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/9541:STAM ^@ http://purl.uniprot.org/uniprot/A0A2K5VRQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/9541:CCDC126 ^@ http://purl.uniprot.org/uniprot/A0A8J8XLQ2|||http://purl.uniprot.org/uniprot/G7P0Q6|||http://purl.uniprot.org/uniprot/I7GKP5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:EDEM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEL9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/9541:DSG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UXA4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/9541:ACSS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1S4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:ALKBH7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQX0 ^@ Similarity ^@ Belongs to the alkB family. http://togogenome.org/gene/9541:TAF8 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5F7|||http://purl.uniprot.org/uniprot/A0A7N9DFF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/9541:SEMA3F ^@ http://purl.uniprot.org/uniprot/A0A2K5TXU6|||http://purl.uniprot.org/uniprot/A0A2K5TXU8 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:APOL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CF82 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/9541:DCTN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VT33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.|||cytoskeleton http://togogenome.org/gene/9541:NSA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/9541:MMS19 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MET18/MMS19 family.|||Component of the CIA complex.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus|||spindle http://togogenome.org/gene/9541:TMOD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSA0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:HOXC6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH79|||http://purl.uniprot.org/uniprot/G7PHW2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TMEM63C ^@ http://purl.uniprot.org/uniprot/A0A2K5WA11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/9541:B4GALT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/9541:ING5 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8Z5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/9541:DMC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/9541:SMC5 ^@ http://purl.uniprot.org/uniprot/G7PSI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:MTFR1 ^@ http://purl.uniprot.org/uniprot/G7PBX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/9541:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W700 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9541:C14H11orf49 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||cytoskeleton http://togogenome.org/gene/9541:GRM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQG4|||http://purl.uniprot.org/uniprot/A0A8J8Y634|||http://purl.uniprot.org/uniprot/G7NZX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:HSF4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/9541:GINS4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEM9|||http://purl.uniprot.org/uniprot/G7PD92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/9541:ELAVL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBH7 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/9541:DDX58 ^@ http://purl.uniprot.org/uniprot/G7PS60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9541:CRX ^@ http://purl.uniprot.org/uniprot/A0A2K5X2T7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SERINC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9541:GREM1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/9541:LIPN ^@ http://purl.uniprot.org/uniprot/A0A8J8Y3P4|||http://purl.uniprot.org/uniprot/G7PDH4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/9541:LOC102123517 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYD7 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/9541:LOC101865054 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPJ1 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9541:NTRK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VL93|||http://purl.uniprot.org/uniprot/A0A2K5VLB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9541:DHX9 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102138308 ^@ http://purl.uniprot.org/uniprot/A0A2K5UID5 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:LOC102122149 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Z4|||http://purl.uniprot.org/uniprot/G7P524 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/9541:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2X5|||http://purl.uniprot.org/uniprot/G7P364 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/9541:CHRNB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:SGCZ ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/9541:CYP1A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YNV8|||http://purl.uniprot.org/uniprot/G7P943 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/9541:TRIM50 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQX6|||http://purl.uniprot.org/uniprot/A0A8J8Y414 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:DOLPP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/9541:OLFML1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZH5|||http://purl.uniprot.org/uniprot/G7PQT9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:EPHA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PPP1R15B ^@ http://purl.uniprot.org/uniprot/A0A8J8XZ24|||http://purl.uniprot.org/uniprot/G7NVE1 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/9541:RPS28 ^@ http://purl.uniprot.org/uniprot/A0A2K5W098|||http://purl.uniprot.org/uniprot/G8F4P1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/9541:PALS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Endomembrane system|||adherens junction|||tight junction http://togogenome.org/gene/9541:PDE1B ^@ http://purl.uniprot.org/uniprot/G7PHX1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:RPS5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WE29|||http://purl.uniprot.org/uniprot/A0A8J8XCP0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/9541:TMEM106C ^@ http://purl.uniprot.org/uniprot/A0A8J8XK76|||http://purl.uniprot.org/uniprot/G7PHP8 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/9541:ROM1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7A2|||http://purl.uniprot.org/uniprot/G7PPU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRPH2/ROM1 family.|||Membrane http://togogenome.org/gene/9541:CKS1B ^@ http://purl.uniprot.org/uniprot/A0A7N9DBP2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/9541:ARMC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP95|||http://purl.uniprot.org/uniprot/G7PBX8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:BICD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TK20|||http://purl.uniprot.org/uniprot/A0A7N9CYZ3 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/9541:ASB8 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBK7|||http://purl.uniprot.org/uniprot/G7PHQ2 ^@ Function|||Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family.|||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/9541:LIG4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CEX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/9541:LOC102121007 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5R5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:AZIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZB4|||http://purl.uniprot.org/uniprot/I7GIW1|||http://purl.uniprot.org/uniprot/I7GJ97|||http://purl.uniprot.org/uniprot/I7GMJ8 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/9541:TRNT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRQ5 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/9541:TMEM86A ^@ http://purl.uniprot.org/uniprot/A0A7N9CDZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/9541:LOC102124735 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:CLDND1 ^@ http://purl.uniprot.org/uniprot/Q4R4Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9541:OSTC ^@ http://purl.uniprot.org/uniprot/A0A2K5WH47|||http://purl.uniprot.org/uniprot/A0A2K5WHC3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/9541:SESN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDA2|||http://purl.uniprot.org/uniprot/A0A7N9D8A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/9541:DESI1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5H3 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/9541:CSNK1A1L ^@ http://purl.uniprot.org/uniprot/A0A2K5VAN7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:SPOCK3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X528 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:CD36 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGH3|||http://purl.uniprot.org/uniprot/Q4R6B4 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/9541:ID2 ^@ http://purl.uniprot.org/uniprot/A0A805PDB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FIBIN ^@ http://purl.uniprot.org/uniprot/A0A7N9CYV4|||http://purl.uniprot.org/uniprot/G8F334 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers.|||Secreted http://togogenome.org/gene/9541:SERPINB10 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9V3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/9541:HIGD2A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y250|||http://purl.uniprot.org/uniprot/G7P6Y9 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9541:ROMO1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SCRN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U580 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/9541:MFSD14A ^@ http://purl.uniprot.org/uniprot/A0A2K5WYA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:ICMT ^@ http://purl.uniprot.org/uniprot/A0A2K5UYR5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:ZNF496 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SERPINC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYN7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/9541:RPL17 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPE4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/9541:SIAH3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZY6|||http://purl.uniprot.org/uniprot/G7PW59 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/9541:CACNB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYA2|||http://purl.uniprot.org/uniprot/A0A2K5TYD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/9541:CLVS2 ^@ http://purl.uniprot.org/uniprot/Q95KF7 ^@ Domain|||Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit ^@ Binding to PtdIns(3,5)P2 is not required for localization.|||Early endosome membrane|||Forms a complex with clathrin heavy chain and gamma-adaptin.|||Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).|||The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/9541:PLCB4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNY0 ^@ Cofactor|||Function ^@ Binds 1 Ca(2+) ion per subunit.|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/9541:CREB5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR28|||http://purl.uniprot.org/uniprot/A0A2K5TR43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.|||Binds to the cAMP response element and activates transcription.|||Nucleus http://togogenome.org/gene/9541:CD68 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNB1|||http://purl.uniprot.org/uniprot/G7PTI2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:SNX17 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0R5|||http://purl.uniprot.org/uniprot/A0A8J8YBZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/9541:RAB3D ^@ http://purl.uniprot.org/uniprot/A0A2K5TXE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/9541:CYP4V2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U594 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:RBCK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VYQ0 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/9541:CCDC103 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/9541:DEFB125 ^@ http://purl.uniprot.org/uniprot/A4H241|||http://purl.uniprot.org/uniprot/G7PGQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:TRIM27 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5W7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102131393 ^@ http://purl.uniprot.org/uniprot/A0A2K5X0G8 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/9541:C10H20orf27 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJP1 ^@ Similarity ^@ Belongs to the ADISSP family. http://togogenome.org/gene/9541:GABRR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTB5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:TBCCD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/9541:ZZZ3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFG3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CEP76 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/9541:PPDPFL ^@ http://purl.uniprot.org/uniprot/A0A2K5VPQ9 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/9541:ADCY4 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5W7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/9541:TNFSF8 ^@ http://purl.uniprot.org/uniprot/A0A7N9CVX7 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/9541:AWAT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDP5|||http://purl.uniprot.org/uniprot/G7Q2Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:RALB ^@ http://purl.uniprot.org/uniprot/Q4R379 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).|||Belongs to the small GTPase superfamily. Ras family.|||Cell membrane|||Interacts with EXOC2/Sec5 and EXOC8/Exo84. Interacts (via effector domain) with RALBP1.|||Midbody|||Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).|||Prenylation is essential for membrane localization.|||The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of some geranylgeranyltransferase I inhibitors. http://togogenome.org/gene/9541:ANHX ^@ http://purl.uniprot.org/uniprot/A0A7N9CDR5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:SCML1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TNJ0|||http://purl.uniprot.org/uniprot/A0A2K5TNJ3 ^@ Similarity ^@ Belongs to the SCM family. http://togogenome.org/gene/9541:CDO1 ^@ http://purl.uniprot.org/uniprot/G7P830 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/9541:CUL1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CNI7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/9541:LOC102138899 ^@ http://purl.uniprot.org/uniprot/G7NWJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TGM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXI8 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/9541:TARBP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TARBP2 family.|||Cytoplasm|||Nucleus|||Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.|||Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).|||perinuclear region http://togogenome.org/gene/9541:SERP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VW72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/9541:RBM5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWT9|||http://purl.uniprot.org/uniprot/A0A7N9CXB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/9541:LOC102130413 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFX5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9541:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4V1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:GALNT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:FMC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU95 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/9541:LOC102137744 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQP4|||http://purl.uniprot.org/uniprot/G7P2L5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:NR3C1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPH3|||http://purl.uniprot.org/uniprot/G7P8J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/9541:B3GNT5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UET4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:BTC ^@ http://purl.uniprot.org/uniprot/A0A2K5X5E5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SYT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAC0|||http://purl.uniprot.org/uniprot/Q60HC0 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (By similarity).|||Cytoplasm|||Glycosylated.|||Homotetramer (Probable). Heterodimer; heterodimerizes with SYT2 in presence of calcium (By similarity). Interacts with SCAMP5 (By similarity). Interacts with STON2 (By similarity). Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity). Interacts with SV2A, SV2B and SV2C (By similarity). Interacts with RIMS1 (By similarity). Interacts with PRRT2 (By similarity). Interacts with DNAJC5 in a phosphorylation-dependent manner (By similarity). Interacts (via N-terminus) with RAB3A (By similarity). Interacts with SYT12 (By similarity). Interacts with calmodulin (By similarity).|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||The first C2 domain mediates Ca(2+)-dependent phospholipid binding.|||The second C2 domain mediates interaction with SV2A and probably with STN2.|||chromaffin granule membrane|||secretory vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:KCNK9 ^@ http://purl.uniprot.org/uniprot/A0A7N9DCV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane|||pH-dependent, voltage-insensitive, background potassium channel protein. http://togogenome.org/gene/9541:EIF2S1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XGJ1|||http://purl.uniprot.org/uniprot/G7PAK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/9541:GJB3 ^@ http://purl.uniprot.org/uniprot/G7NTG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:PPP3CA ^@ http://purl.uniprot.org/uniprot/A0A2K5WC95 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/9541:DMTF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWT6|||http://purl.uniprot.org/uniprot/A0A8J8YSC6|||http://purl.uniprot.org/uniprot/G7P1W2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:YWHAE ^@ http://purl.uniprot.org/uniprot/Q4R4J3 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/9541:TMEM45B ^@ http://purl.uniprot.org/uniprot/A0A2K5W1T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/9541:MRPS25 ^@ http://purl.uniprot.org/uniprot/A0A8J8XC86|||http://purl.uniprot.org/uniprot/G7PIM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/9541:NETO2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8V7|||http://purl.uniprot.org/uniprot/A0A2K5X9A8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1S8|||http://purl.uniprot.org/uniprot/A0A8J8YKT6|||http://purl.uniprot.org/uniprot/G7P6T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:AREG ^@ http://purl.uniprot.org/uniprot/A0A2K5U4V6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102139903 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RIPPLY1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJ69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ripply family.|||Nucleus http://togogenome.org/gene/9541:CAND1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y752|||http://purl.uniprot.org/uniprot/G7PHZ3 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/9541:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X645 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/9541:SH3GL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9541:PPP1CB ^@ http://purl.uniprot.org/uniprot/A0A7N9CGK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||nucleolus|||nucleoplasm http://togogenome.org/gene/9541:VPS25 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8X3 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/9541:LOC107127349 ^@ http://purl.uniprot.org/uniprot/A0A7N9D771 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/9541:TPM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXJ1|||http://purl.uniprot.org/uniprot/A0A2K5TXK7|||http://purl.uniprot.org/uniprot/G7PS00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/9541:TAT ^@ http://purl.uniprot.org/uniprot/A0A8J8XI10|||http://purl.uniprot.org/uniprot/G7Q1K1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/9541:SMIM5 ^@ http://purl.uniprot.org/uniprot/A0A7N9CHX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SSRP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSE2|||http://purl.uniprot.org/uniprot/G7PQ43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/9541:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRM5|||http://purl.uniprot.org/uniprot/G7NV75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/9541:KCNMA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VSL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.|||Membrane http://togogenome.org/gene/9541:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V741 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:SUMO1 ^@ http://purl.uniprot.org/uniprot/I7G9I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/9541:CYP7B1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UFH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/9541:GPBP1L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSE3|||http://purl.uniprot.org/uniprot/G8F2B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/9541:RAB3GAP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6F7|||http://purl.uniprot.org/uniprot/G7NTY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP regulatory subunit family.|||Cytoplasm http://togogenome.org/gene/9541:C1GALT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWB6|||http://purl.uniprot.org/uniprot/A0A7N9CVW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.|||Membrane http://togogenome.org/gene/9541:KIF21B ^@ http://purl.uniprot.org/uniprot/A0A2K5WZ21 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:BNIP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYL4|||http://purl.uniprot.org/uniprot/A0A2K5TYT0|||http://purl.uniprot.org/uniprot/A0A8J8YQS4|||http://purl.uniprot.org/uniprot/G7PPN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus|||Transcription factor. http://togogenome.org/gene/9541:ATP5MF ^@ http://purl.uniprot.org/uniprot/Q2PFS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:NSUN5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIR5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/9541:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X140 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/9541:C1D ^@ http://purl.uniprot.org/uniprot/A0A8J8XV92|||http://purl.uniprot.org/uniprot/G7NZK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/9541:GPR180 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LRRC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWW0 ^@ Similarity ^@ Belongs to the LAP (LRR and PDZ) protein family. http://togogenome.org/gene/9541:RNASE11 ^@ http://purl.uniprot.org/uniprot/G7P9L6 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:PPFIA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5U522 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/9541:LDB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULR2 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/9541:ANXA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQS9|||http://purl.uniprot.org/uniprot/A0A8J8YR13 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Membrane|||basement membrane http://togogenome.org/gene/9541:LOC102125550 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEA5 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9541:FAM3B ^@ http://purl.uniprot.org/uniprot/A0A2K5X116 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/9541:TMEM150A ^@ http://purl.uniprot.org/uniprot/A0A8J8YQX1|||http://purl.uniprot.org/uniprot/G7PMM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MRPS12 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQN7|||http://purl.uniprot.org/uniprot/G7PXI2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/9541:RNFT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:EPHB1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCA7|||http://purl.uniprot.org/uniprot/G7NXX9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/9541:PTGER4 ^@ http://purl.uniprot.org/uniprot/Q95J39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/9541:FAM91A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6H4 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/9541:NPM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGS6 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/9541:KCNS3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UDN3|||http://purl.uniprot.org/uniprot/G8F573 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:TP63 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC97|||http://purl.uniprot.org/uniprot/A0A2K5VCF3|||http://purl.uniprot.org/uniprot/A0A8J8YGJ4|||http://purl.uniprot.org/uniprot/G7NYP4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:RXRB ^@ http://purl.uniprot.org/uniprot/A0A2K5WBN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/9541:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/I7GLL6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/9541:SUPT3H ^@ http://purl.uniprot.org/uniprot/A0A2K5UI13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:BTAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VR83|||http://purl.uniprot.org/uniprot/A0A2K5VRB0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ACTC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YL82|||http://purl.uniprot.org/uniprot/G7PAP7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:GAPVD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/9541:ELOVL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CIZ6|||http://purl.uniprot.org/uniprot/A0A7N9D9J9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:HTR1F ^@ http://purl.uniprot.org/uniprot/A0A8J8YEW1|||http://purl.uniprot.org/uniprot/G7NZ54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/9541:KCNV2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVN7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:SLC25A53 ^@ http://purl.uniprot.org/uniprot/A0A7N9CVE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/9541:SNRNP27 ^@ http://purl.uniprot.org/uniprot/A0A7N9DFU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/9541:SCOC ^@ http://purl.uniprot.org/uniprot/A0A7N9CUY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/9541:RCL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2J1|||http://purl.uniprot.org/uniprot/G7PSF4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.|||nucleolus http://togogenome.org/gene/9541:KIF5A ^@ http://purl.uniprot.org/uniprot/A0A2K5WRA2|||http://purl.uniprot.org/uniprot/A0A8J8YRW8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:LDAF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/9541:CRY1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQ28|||http://purl.uniprot.org/uniprot/G7PI44 ^@ Cofactor|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/9541:G0S2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJD9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex.|||Mitochondrion|||Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. http://togogenome.org/gene/9541:FASTKD5 ^@ http://purl.uniprot.org/uniprot/Q95KD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAST kinase family.|||Found in a complex with GRSF1, DDX28, DHX30 and FASTKD2. Associates with the 12S mitochondrial rRNA (12S mt-rRNA).|||Plays an important role in the processing of non-canonical mitochondrial mRNA precursors.|||mitochondrion nucleoid http://togogenome.org/gene/9541:CBWD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPK4|||http://purl.uniprot.org/uniprot/A0A7N9CTQ2 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/9541:HPSE2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W315 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/9541:POLR3C ^@ http://purl.uniprot.org/uniprot/A0A8J8YM60|||http://purl.uniprot.org/uniprot/G7NX80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9541:HINT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM01 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/9541:SF3B6 ^@ http://purl.uniprot.org/uniprot/A0A2K5W230 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TACR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH04 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/9541:KCNH5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZ53|||http://purl.uniprot.org/uniprot/G7PAH7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SLC25A32 ^@ http://purl.uniprot.org/uniprot/Q95J75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:MTHFS ^@ http://purl.uniprot.org/uniprot/A0A2K5V823 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/9541:IPO13 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1H8|||http://purl.uniprot.org/uniprot/G7NUX7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/9541:ETNPPL ^@ http://purl.uniprot.org/uniprot/A0A2K5UWR7 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/9541:ASAH2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEH4 ^@ Similarity ^@ Belongs to the neutral ceramidase family. http://togogenome.org/gene/9541:PROKR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRW4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:DERL2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH18|||http://purl.uniprot.org/uniprot/G7PTB3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PIK3CB ^@ http://purl.uniprot.org/uniprot/A0A2K5U222|||http://purl.uniprot.org/uniprot/A0A8J8XJE7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:EMC6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKN3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SHMT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHN6 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/9541:PTK2B ^@ http://purl.uniprot.org/uniprot/A0A2K5WCP6|||http://purl.uniprot.org/uniprot/A0A2K5WCQ3|||http://purl.uniprot.org/uniprot/A0A8J8Y222 ^@ Subcellular Location Annotation ^@ Cell membrane|||cell cortex|||focal adhesion http://togogenome.org/gene/9541:IVD ^@ http://purl.uniprot.org/uniprot/G8F3Q0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/9541:EXO5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFL1|||http://purl.uniprot.org/uniprot/G7NUD7 ^@ Similarity ^@ Belongs to the EXO5 family. http://togogenome.org/gene/9541:EXOSC5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5R2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:ASB9 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5D5 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:GRB7 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/9541:CLDN6 ^@ http://purl.uniprot.org/uniprot/G7Q0B0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:SLC25A5 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAS1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9541:PSKH1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YA10|||http://purl.uniprot.org/uniprot/G7Q1F3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:RBMX ^@ http://purl.uniprot.org/uniprot/Q4R7F0 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Arg-185 is dimethylated, probably to asymmetric dimethylarginine.|||Homomultimer. Found in the supraspliceosome complex. Identified in the spliceosome C complex. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, NCOA5 and PPP1CA. Interacts with CLK2, KHDRBS2, KHDRBS3, SAFB/SAFB1, TRA2B and YTHDC1. Interacts with ERAP1; the interaction is RNA-independent (By similarity). Interacts with PPIA/CYPA (By similarity).|||Nucleus|||O-glycosylated.|||RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity).|||The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its splicing activity does not require direct binding to RNA. http://togogenome.org/gene/9541:LOC102133005 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1Z1 ^@ Function|||Similarity ^@ Belongs to the TYW1 family.|||Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis. http://togogenome.org/gene/9541:RIN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W721|||http://purl.uniprot.org/uniprot/A0A2K5W777 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/9541:NCOA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/9541:ALG13 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHX9|||http://purl.uniprot.org/uniprot/A0A2K5VHZ5 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/9541:FOXRED1 ^@ http://purl.uniprot.org/uniprot/Q4R510 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with components of the mitochondrial respiratory chain complex I.|||Mitochondrion inner membrane|||Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly. http://togogenome.org/gene/9541:TMEM38B ^@ http://purl.uniprot.org/uniprot/A0A2K5X7D5|||http://purl.uniprot.org/uniprot/A0A7N9CP35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/9541:GABRG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLM2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:PRDX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UML5 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/9541:DYNLRB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3W8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/9541:SMIM24 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1N4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:AIF1L ^@ http://purl.uniprot.org/uniprot/A0A2K5X8V1 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/9541:SLC12A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5U2D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/9541:CASP8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHB0 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGH5|||http://purl.uniprot.org/uniprot/A0A2K5UGL9|||http://purl.uniprot.org/uniprot/A0A2K5UGM6 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/9541:RBBP7 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y4H5|||http://purl.uniprot.org/uniprot/G7Q2B1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:INTS7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/9541:TLE5 ^@ http://purl.uniprot.org/uniprot/I7GPM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/9541:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG71|||http://purl.uniprot.org/uniprot/G8F4D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/9541:SETD7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TYA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.|||Chromosome|||Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.|||Nucleus http://togogenome.org/gene/9541:FUT8 ^@ http://purl.uniprot.org/uniprot/A0A2K5TRW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:CCNL2 ^@ http://purl.uniprot.org/uniprot/I7GHV1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:UGDH ^@ http://purl.uniprot.org/uniprot/A0A2K5WLS0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/9541:PPP4R2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ74 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/9541:DBT ^@ http://purl.uniprot.org/uniprot/A0A2K5VT48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:SLC17A9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:STC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TR46 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/9541:SERINC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y6V0|||http://purl.uniprot.org/uniprot/G7P394 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/9541:DNASE1L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1N6 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/9541:GALT ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7V6|||http://purl.uniprot.org/uniprot/G7PS28 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/9541:THOC7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/9541:PDE11A ^@ http://purl.uniprot.org/uniprot/A0A8J8YBB3|||http://purl.uniprot.org/uniprot/G7PKX5 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/9541:LOC102138242 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD58 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DPYSL5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN44 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/9541:ZKSCAN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102140088 ^@ http://purl.uniprot.org/uniprot/A0A2K5V684 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/9541:ADK ^@ http://purl.uniprot.org/uniprot/A0A2K5VIG9|||http://purl.uniprot.org/uniprot/A0A7N9D865 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/9541:FKTN ^@ http://purl.uniprot.org/uniprot/A0A7N9D6T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LicD transferase family.|||Golgi apparatus membrane http://togogenome.org/gene/9541:EREG ^@ http://purl.uniprot.org/uniprot/A0A2K5UAU1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:TMED2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/9541:GNG12 ^@ http://purl.uniprot.org/uniprot/A0A2K5VFG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/9541:PFDN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9W8 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9541:LCA5L ^@ http://purl.uniprot.org/uniprot/A0A8J8YMB0|||http://purl.uniprot.org/uniprot/G7P0Z6 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/9541:FAM187A ^@ http://purl.uniprot.org/uniprot/A0A8J8YDG6|||http://purl.uniprot.org/uniprot/G7PV11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/9541:GPR119 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTZ9|||http://purl.uniprot.org/uniprot/G7Q3P2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:GDPD1 ^@ http://purl.uniprot.org/uniprot/G7PUH0 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/9541:CHST4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CXJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/9541:AS3MT ^@ http://purl.uniprot.org/uniprot/A0A7N9D6B9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Arsenite methyltransferase family. http://togogenome.org/gene/9541:RFX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7D6|||http://purl.uniprot.org/uniprot/A0A2K5X7I3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:H1-6 ^@ http://purl.uniprot.org/uniprot/G7P2M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/9541:TBC1D23 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTW2|||http://purl.uniprot.org/uniprot/A0A2K5UTY6|||http://purl.uniprot.org/uniprot/A0A2K5UU06|||http://purl.uniprot.org/uniprot/A0A8J8XGF9 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/9541:EWSR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/9541:SSU72 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/9541:FABP4 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKQ0|||http://purl.uniprot.org/uniprot/G7PC40 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:ITK ^@ http://purl.uniprot.org/uniprot/A0A2K5X9J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9541:TMED6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XY41|||http://purl.uniprot.org/uniprot/G7Q1I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:ZC3HC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPS7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:P2RY4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UD43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SUSD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIA2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102119400 ^@ http://purl.uniprot.org/uniprot/A0A2K5X463|||http://purl.uniprot.org/uniprot/Q95LR9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:SSR4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAD8|||http://purl.uniprot.org/uniprot/G7Q200 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-delta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/9541:GPX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDB5 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/9541:HMGN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4W9|||http://purl.uniprot.org/uniprot/A0A2K5V4Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/9541:KRT82 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5C3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:P2RX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/9541:SEC23A ^@ http://purl.uniprot.org/uniprot/A0A2K5UC61|||http://purl.uniprot.org/uniprot/A0A8J8Y3C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:TGFB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TZI7|||http://purl.uniprot.org/uniprot/A0A7N9D1Q4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/9541:PPP3R1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D4V0 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/9541:ABI2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVD3|||http://purl.uniprot.org/uniprot/A0A7N9CIX9|||http://purl.uniprot.org/uniprot/A0A7N9D0E3|||http://purl.uniprot.org/uniprot/A0A7N9DC51|||http://purl.uniprot.org/uniprot/A0A7N9IF93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/9541:QRFPR ^@ http://purl.uniprot.org/uniprot/A0A2K5X3X2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:CRYGS ^@ http://purl.uniprot.org/uniprot/A0A2K5TLY3|||http://purl.uniprot.org/uniprot/A0A8J8XT43 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/9541:LRP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC84 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDLR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:PFDN6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YMI4|||http://purl.uniprot.org/uniprot/G7P2S7 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/9541:CWC15 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJY0 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/9541:GABRG3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WT79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:TCP11L1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU60 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/9541:SLC5A12 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GRIA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWT7|||http://purl.uniprot.org/uniprot/A0A2K5TWV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/9541:LEPR ^@ http://purl.uniprot.org/uniprot/A0A2K5U8P7|||http://purl.uniprot.org/uniprot/A0A2K5U8T0 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9541:ANAPC4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI1 ^@ Function|||Similarity ^@ Belongs to the APC4 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/9541:POU1F1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/9541:PPM1L ^@ http://purl.uniprot.org/uniprot/A0A8J8YJJ4|||http://purl.uniprot.org/uniprot/G7NZI0 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/9541:GAPDH ^@ http://purl.uniprot.org/uniprot/A0A0A7KUP9 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/9541:HIGD1B ^@ http://purl.uniprot.org/uniprot/A0A7N9DBW9 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/9541:EPAS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDY2 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/9541:CCNH ^@ http://purl.uniprot.org/uniprot/A0A2K5UEC9 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family. Cyclin C subfamily.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/9541:SLC9A9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YKJ7|||http://purl.uniprot.org/uniprot/G7P004 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Cell membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/9541:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/9541:KCTD7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X953 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:IL36RN ^@ http://purl.uniprot.org/uniprot/A0A2K5UWR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/9541:ACTR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VKV4|||http://purl.uniprot.org/uniprot/A0A2K5VL34 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/9541:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TSF4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/9541:CDK7 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTM9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/9541:NXPH3 ^@ http://purl.uniprot.org/uniprot/G7PU90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/9541:GABRA3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAB1|||http://purl.uniprot.org/uniprot/G7Q1Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:MEF2D ^@ http://purl.uniprot.org/uniprot/A0A2K5US28|||http://purl.uniprot.org/uniprot/A0A2K5USA9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TECRL ^@ http://purl.uniprot.org/uniprot/A0A2K5WN39|||http://purl.uniprot.org/uniprot/A0A8J8Y262 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/9541:TMEM91 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZP0|||http://purl.uniprot.org/uniprot/A0A7N9C7K4 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/9541:PKP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB38 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9541:CFLAR ^@ http://purl.uniprot.org/uniprot/A0A2K5W001 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/9541:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2R5|||http://purl.uniprot.org/uniprot/G7P4X1|||http://purl.uniprot.org/uniprot/Q2PG46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM (By similarity).|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.|||Mitochondrion|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. http://togogenome.org/gene/9541:LYVE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWG3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:FAR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9I9D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/9541:RECQL ^@ http://purl.uniprot.org/uniprot/A0A2K5UWF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/9541:HOMER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U708 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/9541:SUN3 ^@ http://purl.uniprot.org/uniprot/Q95LV7 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Self-associates. Interacts with SYNE1 and SPAG4/SUN4. Proposed to form a spermatogenesis-specific LINC complex with SYNE1 during sperm head formation possibly implicating a SUN domain-based heterotrimer with SPAG4/SUN4 associating with SYNE1.|||The short coiled coil domain is proposed to be not involved in load-bearing and force transmission from the cytoskeleton but in mere nucleus anchorage instead. http://togogenome.org/gene/9541:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/A0A2K5X667|||http://purl.uniprot.org/uniprot/A0A2K5X6A3 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/9541:GABRA4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XR95|||http://purl.uniprot.org/uniprot/G7P5I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/9541:USP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4E6|||http://purl.uniprot.org/uniprot/A0A8J8XDN1|||http://purl.uniprot.org/uniprot/G7PPB3 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/9541:LOC102140578 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4Q6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:MDGA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1X5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:CCNC ^@ http://purl.uniprot.org/uniprot/A0A2K5USI3|||http://purl.uniprot.org/uniprot/A0A2K5USJ7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:DERL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/9541:SCFD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X101 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:ZNF532 ^@ http://purl.uniprot.org/uniprot/A0A2K5UK98 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:RPS7 ^@ http://purl.uniprot.org/uniprot/A0A2K5W178 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||centrosome http://togogenome.org/gene/9541:CDH8 ^@ http://purl.uniprot.org/uniprot/G7Q1A7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:COPS7B ^@ http://purl.uniprot.org/uniprot/A0A2K5WYS7|||http://purl.uniprot.org/uniprot/A0A7N9CBY3|||http://purl.uniprot.org/uniprot/A0A7N9D9U6|||http://purl.uniprot.org/uniprot/A0A8J8XMR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:ANXA11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VTK4 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/9541:NECAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U244|||http://purl.uniprot.org/uniprot/A0A2K5U268|||http://purl.uniprot.org/uniprot/A0A2K5U270 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/9541:RAB9A ^@ http://purl.uniprot.org/uniprot/A0A8J8Y101|||http://purl.uniprot.org/uniprot/G7Q287 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/9541:SLC13A5 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y478|||http://purl.uniprot.org/uniprot/G7PTE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/9541:TOM1L1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YAH0|||http://purl.uniprot.org/uniprot/G7PUC6 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/9541:SLC17A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5L8|||http://purl.uniprot.org/uniprot/A0A8J8YQC8|||http://purl.uniprot.org/uniprot/G7P2K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:AKR1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W354|||http://purl.uniprot.org/uniprot/A0A2K5W359|||http://purl.uniprot.org/uniprot/G8F2B0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||Monomer.|||cytosol http://togogenome.org/gene/9541:LAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7V5 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M17 family.|||Homohexamer. http://togogenome.org/gene/9541:RABEP2 ^@ http://purl.uniprot.org/uniprot/Q4R6D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Cytoplasm|||Early endosome|||Endosome http://togogenome.org/gene/9541:PPP4R3C ^@ http://purl.uniprot.org/uniprot/G7Q2E9 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/9541:ARMCX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJD7|||http://purl.uniprot.org/uniprot/G7Q398 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eutherian X-chromosome-specific Armcx family.|||Membrane http://togogenome.org/gene/9541:NETO1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHI9|||http://purl.uniprot.org/uniprot/Q2PFY8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:IFIH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/9541:SLC48A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WP10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRG family.|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/9541:FAM168B ^@ http://purl.uniprot.org/uniprot/A0A2K5WWF8|||http://purl.uniprot.org/uniprot/A0A7N9CS80 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/9541:KCNK16 ^@ http://purl.uniprot.org/uniprot/A0A2K5W678 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/9541:PTX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEN7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DAZAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U9I9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus speckle|||nuclear body http://togogenome.org/gene/9541:ZBED9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VS64 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:S100B ^@ http://purl.uniprot.org/uniprot/A0A8J8YNZ8|||http://purl.uniprot.org/uniprot/G7PWM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/9541:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2S7|||http://purl.uniprot.org/uniprot/G7P3M6 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/9541:LOC102117303 ^@ http://purl.uniprot.org/uniprot/A0A7N9CI04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:MUSTN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MUSTANG family.|||Nucleus http://togogenome.org/gene/9541:CCNA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBK9|||http://purl.uniprot.org/uniprot/Q4R337 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/9541:SDHAF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/9541:MCTP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4T4|||http://purl.uniprot.org/uniprot/A0A2K5X4Y1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ZDHHC23 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1H6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:KCNH7 ^@ http://purl.uniprot.org/uniprot/A0A2K5URQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ACP7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WEP7|||http://purl.uniprot.org/uniprot/A0A8J8XKK7|||http://purl.uniprot.org/uniprot/G7PXI5 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/9541:TMSB15A ^@ http://purl.uniprot.org/uniprot/A0A8J8XD17|||http://purl.uniprot.org/uniprot/G7Q3A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/9541:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WSH3 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/9541:DUSP26 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVD9|||http://purl.uniprot.org/uniprot/A0A2K5VVF9 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/9541:MAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6F5|||http://purl.uniprot.org/uniprot/A0A2K5W6L6|||http://purl.uniprot.org/uniprot/A0A7N9DEN1|||http://purl.uniprot.org/uniprot/G7PLB5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:GAB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAB8 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/9541:FSCN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W420 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/9541:GRIN3A ^@ http://purl.uniprot.org/uniprot/A0A2K5VQ27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/9541:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJT8|||http://purl.uniprot.org/uniprot/G7P6X2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:SENP8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YN89|||http://purl.uniprot.org/uniprot/G7P914 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/9541:LOC101866922 ^@ http://purl.uniprot.org/uniprot/A0A2K5UU73 ^@ Function|||Subcellular Location Annotation ^@ Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.|||Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|||Secreted http://togogenome.org/gene/9541:NDFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WAN9 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/9541:PIERCE1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCQ0|||http://purl.uniprot.org/uniprot/G8F5E5 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/9541:NTMT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5J0|||http://purl.uniprot.org/uniprot/G7P656 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/9541:RNASE10 ^@ http://purl.uniprot.org/uniprot/A0A7N9CQW9 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/9541:PRPF19 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/9541:TLR7 ^@ http://purl.uniprot.org/uniprot/B3Y652 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/9541:TRMT6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZJ3|||http://purl.uniprot.org/uniprot/G7PGX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/9541:CCT3 ^@ http://purl.uniprot.org/uniprot/A0A8J8YRI3|||http://purl.uniprot.org/uniprot/Q25QN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||Cytoplasm http://togogenome.org/gene/9541:GHR ^@ http://purl.uniprot.org/uniprot/A0A2K5WH01|||http://purl.uniprot.org/uniprot/A0A7N9D090 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Cell membrane|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. http://togogenome.org/gene/9541:CCDC47 ^@ http://purl.uniprot.org/uniprot/A0A2K5WED9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC47 family.|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/9541:HOXC9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZ58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/9541:MOB3A ^@ http://purl.uniprot.org/uniprot/A0A2K5W9A1 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:LCLAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W176 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/9541:DKKL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WPQ3|||http://purl.uniprot.org/uniprot/G7PY70 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/9541:DHRS3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y406|||http://purl.uniprot.org/uniprot/G7NU67 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:TBX20 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y975|||http://purl.uniprot.org/uniprot/G7P0F2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:LOC102126517 ^@ http://purl.uniprot.org/uniprot/A0A7N9D902 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9541:CRISP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1H1 ^@ Caution|||Similarity ^@ Belongs to the CRISP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:HTR1E ^@ http://purl.uniprot.org/uniprot/A0A8J8YCP3|||http://purl.uniprot.org/uniprot/G7P3J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SH3BGRL ^@ http://purl.uniprot.org/uniprot/G7Q351|||http://purl.uniprot.org/uniprot/Q4R7R5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.|||Belongs to the SH3BGR family.|||Cell membrane|||Monomer. Interacts with PFN1/Profilin-1. Interacts with ERBB2. Interacts with ATG12. Interacts with BECN1. Interacts with translating ribosomes.|||The SH3-binding domain is buried in the tertiary structure, and it therefore unclear whether it directly mediates protein-binding.|||cytosol http://togogenome.org/gene/9541:IL25 ^@ http://purl.uniprot.org/uniprot/A0A2K5TY65|||http://purl.uniprot.org/uniprot/G7P9V9 ^@ Similarity ^@ Belongs to the IL-17 family. http://togogenome.org/gene/9541:RAB8A ^@ http://purl.uniprot.org/uniprot/Q4R5P1 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Cytoplasm|||Golgi apparatus|||Interacts (GTP-bound form) with MICALL1; regulates RAB8A association with recycling endosomes (By similarity). Interacts with MICALL2; competes with RAB13 and is involved in E-cadherin endocytic recycling (By similarity). Interacts (GTP-bound form) with MICAL1, MICALCL, MICAL3 and EHBP1L1; two molecules of RAB8A can bind to one molecule of the effector protein; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible (By similarity). Interacts (GTP-bound form) with EHBP1 (By similarity). Interacts with EHD1 (By similarity). Interacts with MAP4K2 and SYTL4 (By similarity). Interacts with SGSM1 and SGSM3 (By similarity). Interacts with RABIF, RIMS2, RPH3A and RPH3A (By similarity). Interacts with OPTN (By similarity). Interacts with RAB3IP (By similarity). Interacts with MYO5B (By similarity). Interacts with CIMAP3 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with OCRL (By similarity). Interacts with AHI1 (By similarity). Interacts with DCDC1 (By similarity). Interacts with LRRK2; interaction facilitates phosphorylation of Thr-72 (By similarity). Interacts with RAB31P, GDI1, GDI2, CHM, CHML, RABGGTA, RABGGTB, TBC1D15 and INPP5B; these interactions are dependent on Thr-72 not being phosphorylated (By similarity). Interacts with RILPL1 and RILPL2; these interactions are dependent on the phosphorylation of Thr-72 by LRRK2 (By similarity). Interacts with DZIP1; prevents inhibition by the GDP-dissociation inhibitor GDI2 (By similarity).|||Midbody|||Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.|||Recycling endosome membrane|||Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase (By similarity). Activated in response to insulin (By similarity).|||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization. Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (By similarity).|||centriole|||cilium|||cilium basal body|||phagosome membrane http://togogenome.org/gene/9541:METTL4 ^@ http://purl.uniprot.org/uniprot/G7PWG2 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/9541:DAPK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5ULA9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:LOC102124448 ^@ http://purl.uniprot.org/uniprot/A0A2K5W923 ^@ Similarity ^@ Belongs to the GAGE family. http://togogenome.org/gene/9541:MYO1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ33|||http://purl.uniprot.org/uniprot/A0A2K5VJ37|||http://purl.uniprot.org/uniprot/A0A8J8XWY6|||http://purl.uniprot.org/uniprot/G7PL24 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:APPL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAJ3 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/9541:PTPRB ^@ http://purl.uniprot.org/uniprot/A0A2K5U774|||http://purl.uniprot.org/uniprot/A0A2K5U787 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. http://togogenome.org/gene/9541:FBXO34 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEC7 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/9541:SEPTIN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5X3R5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:SLCO1B3 ^@ http://purl.uniprot.org/uniprot/L7TAY6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A2K5TKY5|||http://purl.uniprot.org/uniprot/A0A2K5TKY9|||http://purl.uniprot.org/uniprot/A0A8J8XQD2|||http://purl.uniprot.org/uniprot/G7NYQ4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:LOC102123375 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUC1|||http://purl.uniprot.org/uniprot/A0A2K5WUC7 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/9541:EXT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TXF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SUPT5H ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT5 family.|||Nucleus http://togogenome.org/gene/9541:PRORP ^@ http://purl.uniprot.org/uniprot/Q4R366 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPR family. P subfamily.|||Binds 2 Mg(2+) or Mg(2+) ions per subunit.|||Catalytic component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3.|||Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.|||Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion.|||Displays a distorted and non-productive active site that probably switches to a fully productive state only upon association with TRMT10C/MRPP1, HSD17B10/MRPP2 and pre-tRNA substrate.|||Mitochondrion http://togogenome.org/gene/9541:FAM110B ^@ http://purl.uniprot.org/uniprot/A0A8J8XF66|||http://purl.uniprot.org/uniprot/G7PBW3 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9541:TIMELESS ^@ http://purl.uniprot.org/uniprot/A0A2K5UPM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the timeless family.|||Nucleus http://togogenome.org/gene/9541:SETDB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3M8 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/9541:KLHL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WGW0|||http://purl.uniprot.org/uniprot/A0A7N9D103 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KLHL3 family.|||cytoskeleton|||cytosol http://togogenome.org/gene/9541:AMER1 ^@ http://purl.uniprot.org/uniprot/G7Q2W4 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/9541:OAZ1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CEE9 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/9541:LOC102132250 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJZ0 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/9541:LOC102118065 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:HMX2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CFD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EMP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5V5C5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Probably involved in cell proliferation and cell-cell interactions. http://togogenome.org/gene/9541:GPR17 ^@ http://purl.uniprot.org/uniprot/A0A2K5W356 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:UNC5B ^@ http://purl.uniprot.org/uniprot/A0A2K5VIX7|||http://purl.uniprot.org/uniprot/A0A2K5VJ03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/9541:SYCP3 ^@ http://purl.uniprot.org/uniprot/Q4R764 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XLR/SYCP3 family.|||Chromosome|||Component of the lateral elements of synaptonemal complexes (By similarity). Homotetramer; the tetrameric helix bundles assemble end to end into long homopolimeric fibers that exhibit a transversal striation with a periodicity of about 20 nm (in vitro) (By similarity). Interacts with SYCP2 (By similarity). Forms a complex with EWSR1, PRDM9, REC8 and SYCP1; complex formation is dependent of phosphorylated form of REC8 and requires PRDM9 bound to hotspot DNA; EWSR1 joins PRDM9 with the chromosomal axis through REC8 (By similarity).|||Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.|||Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.|||Nucleus|||Phosphorylated.|||centromere http://togogenome.org/gene/9541:ENTPD7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1J8 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/9541:ERMN ^@ http://purl.uniprot.org/uniprot/A0A8J8YRE1|||http://purl.uniprot.org/uniprot/G7PKL9 ^@ Function|||Subunit ^@ Binds actin.|||Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS. http://togogenome.org/gene/9541:FLVCR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X507|||http://purl.uniprot.org/uniprot/A0A7N9CV21|||http://purl.uniprot.org/uniprot/A0A7N9IDF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:RNF111 ^@ http://purl.uniprot.org/uniprot/A0A8J8XF14|||http://purl.uniprot.org/uniprot/G7PBK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Arkadia family.|||PML body http://togogenome.org/gene/9541:HMGCS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHJ3 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/9541:GTF2H4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIY7|||http://purl.uniprot.org/uniprot/A0A8J8YN01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/9541:MAGOHB ^@ http://purl.uniprot.org/uniprot/A0A2K5V0C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/9541:CDC14A ^@ http://purl.uniprot.org/uniprot/A0A2K5X9F1|||http://purl.uniprot.org/uniprot/G7NV31 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/9541:SLC5A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5UVT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TSPAN3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:RPL21 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG77 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9541:AMIGO2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XCC5|||http://purl.uniprot.org/uniprot/G7PHN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. AMIGO family.|||Membrane http://togogenome.org/gene/9541:RGN ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0M3|||http://purl.uniprot.org/uniprot/G7Q2K7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/9541:VPS45 ^@ http://purl.uniprot.org/uniprot/G7NTS3 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/9541:GCNT4 ^@ http://purl.uniprot.org/uniprot/A0A2K5UCK1|||http://purl.uniprot.org/uniprot/G7P7R4 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:EIF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WRG3|||http://purl.uniprot.org/uniprot/A0A8J8XC80 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/9541:SST ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0N9|||http://purl.uniprot.org/uniprot/G7NYN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/9541:BCKDK ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ84|||http://purl.uniprot.org/uniprot/Q95LS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/9541:GNAT3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U8X8|||http://purl.uniprot.org/uniprot/A0A8J8XRP4 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:SEC24A ^@ http://purl.uniprot.org/uniprot/A0A2K5W3V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/9541:PLPP5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/9541:SPIN3 ^@ http://purl.uniprot.org/uniprot/G8F4G1 ^@ Similarity ^@ Belongs to the SPIN/STSY family. http://togogenome.org/gene/9541:LOC101926003 ^@ http://purl.uniprot.org/uniprot/A0A7N9D8L8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with UHRF2/NIRF.|||May be involved in cell cycle regulation.|||Nucleus http://togogenome.org/gene/9541:MALSU1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHP6 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/9541:ATG4A ^@ http://purl.uniprot.org/uniprot/A0A2K5X4I7|||http://purl.uniprot.org/uniprot/A0A2K5X4K0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/9541:LOC102124401 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIW7 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. http://togogenome.org/gene/9541:SLC39A8 ^@ http://purl.uniprot.org/uniprot/A0A7N9IBY7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:KCTD14 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y5I7|||http://purl.uniprot.org/uniprot/G7PNB4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:PI4KB ^@ http://purl.uniprot.org/uniprot/A0A2K5UC81|||http://purl.uniprot.org/uniprot/A0A2K5UC84 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/9541:COQ8B ^@ http://purl.uniprot.org/uniprot/A0A2K5WMA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane http://togogenome.org/gene/9541:KEG98_p08 ^@ http://purl.uniprot.org/uniprot/C3W4Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVC8|||http://purl.uniprot.org/uniprot/G7Q2X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:LOC102120931 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y0H3|||http://purl.uniprot.org/uniprot/G7PCD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-defensin family.|||Has antibacterial activity.|||Secreted http://togogenome.org/gene/9541:GOSR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9DD30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.|||Membrane http://togogenome.org/gene/9541:ALX1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YN78|||http://purl.uniprot.org/uniprot/G7PIK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:EMP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VF24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/9541:TRIM15 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBH5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:TSC22D1 ^@ http://purl.uniprot.org/uniprot/Q4R4H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TSC-22/Dip/Bun family.|||Cell membrane|||Cytoplasm|||Forms a heterodimer with TSC22D4/THG1 (By similarity). Interacts with histone H1-2 (By similarity). Interacts with GNL3 (By similarity).|||Forms a heterodimer with TSC22D4/THG1.|||Forms homodimers (By similarity). Forms heterodimers (By similarity). Component of a complex composed of TSC22D1 (via N-terminus), TGFBR1 and TGFBR2; the interaction between TSC22D1 and TGFBR1 is inhibited by SMAD7 and promoted by TGFB1 (By similarity). Interacts with SMAD7; the interaction requires TGF-beta and the interaction is inhibited by TGFBR1 (By similarity). Interacts with TPT1/fortilin; interaction results in the destabilization of TSC22D1 protein and prevents TSC22D1-mediated apoptosis (By similarity). Interacts with SMAD4 (via N-terminus) (By similarity). Interacts with ACVRL1/ALK1, ACVR1/ALK2, BMPR1A/ALK3, ACVR1B/ALK4, BMPR1B/ALK6, ACVR2A/ACTRII, and BMPR2 (By similarity). Interacts with SMAD6 (By similarity). Interacts with TFE3; the interaction is enhanced in the presence of TGF-beta (By similarity).|||May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells.|||Mitochondrion|||Nucleus|||Positively regulates cell death in response to TGFB3 during mammary gland involution.|||Transcriptional repressor (By similarity). Acts on the C-type natriuretic peptide (CNP) promoter (By similarity). Acts to promote CASP3-mediated apoptosis (By similarity). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (By similarity). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (By similarity). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (By similarity). http://togogenome.org/gene/9541:SRRT ^@ http://purl.uniprot.org/uniprot/A0A2K5VDU6|||http://purl.uniprot.org/uniprot/G8F583 ^@ Similarity ^@ Belongs to the ARS2 family. http://togogenome.org/gene/9541:FAM110A ^@ http://purl.uniprot.org/uniprot/A0A2K5UP52 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/9541:FUCA2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CHN9 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/9541:GIPC1 ^@ http://purl.uniprot.org/uniprot/G7PZL8 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/9541:ACSM1 ^@ http://purl.uniprot.org/uniprot/G7Q0M8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/G7PCG4|||http://purl.uniprot.org/uniprot/Q4R5H9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/9541:NUP58 ^@ http://purl.uniprot.org/uniprot/Q4R7P1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/9541:STIM1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X2B5|||http://purl.uniprot.org/uniprot/A0A2K5X2B6|||http://purl.uniprot.org/uniprot/A0A8J8Y995|||http://purl.uniprot.org/uniprot/G7PQZ7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:KCNV1 ^@ http://purl.uniprot.org/uniprot/G7PCI9|||http://purl.uniprot.org/uniprot/Q9GKU7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Cell membrane|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.|||The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. http://togogenome.org/gene/9541:PHB2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W040 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:TMEM150C ^@ http://purl.uniprot.org/uniprot/A0A2K5ULK2|||http://purl.uniprot.org/uniprot/A0A2K5ULQ0|||http://purl.uniprot.org/uniprot/A0A7N9CHJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:OTUB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6T3 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/9541:PCYT1B ^@ http://purl.uniprot.org/uniprot/A0A2K5U167 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/9541:IRAK4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3Y9|||http://purl.uniprot.org/uniprot/A0A2K5V433 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/9541:AGTR2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XX36|||http://purl.uniprot.org/uniprot/G7Q3I3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/9541:YME1L1 ^@ http://purl.uniprot.org/uniprot/Q4R4Z4 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/9541:KCTD18 ^@ http://purl.uniprot.org/uniprot/A0A8J8XEL6|||http://purl.uniprot.org/uniprot/G7PL53 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:ALKAL1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XRI4|||http://purl.uniprot.org/uniprot/G7PBU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/9541:LOC102127963 ^@ http://purl.uniprot.org/uniprot/A0A2K5UIM1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:TOMM7 ^@ http://purl.uniprot.org/uniprot/A0A7N9D4I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:DPM3 ^@ http://purl.uniprot.org/uniprot/G7NV63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/9541:MBOAT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:CXCL12 ^@ http://purl.uniprot.org/uniprot/A0A2K5WXU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:CTLA4 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1Z9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/9541:LOC102124330 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/9541:CNKSR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WKI3|||http://purl.uniprot.org/uniprot/A0A2K5WKN7|||http://purl.uniprot.org/uniprot/A0A2K5WKU7 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/9541:LOC102139204 ^@ http://purl.uniprot.org/uniprot/A0A2K5V4R6|||http://purl.uniprot.org/uniprot/G8F302 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Antimicrobial protein that is an integral component of the innate immune system (By similarity). Binds to bacterial lipopolysaccharides (LPS) (By similarity). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (By similarity). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (By similarity). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro).|||Belongs to the cathelicidin family.|||Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro).|||Monomer, homodimer or homotrimer (in vitro) (By similarity). Oligomerizes as tetra- or hexamer in solution (in vitro).|||Secreted|||Vesicle http://togogenome.org/gene/9541:MCIDAS ^@ http://purl.uniprot.org/uniprot/A0A7N9DC94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/9541:C4H6orf89 ^@ http://purl.uniprot.org/uniprot/A0A7N9CFN8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:OPALIN ^@ http://purl.uniprot.org/uniprot/A0A2K5VDN3|||http://purl.uniprot.org/uniprot/A0A7N9D3J9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.|||Membrane http://togogenome.org/gene/9541:NOVA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3P4 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with PTBP2; the interaction is direct.|||Nucleus http://togogenome.org/gene/9541:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:LOC102147063 ^@ http://purl.uniprot.org/uniprot/A0A2K5U042 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/9541:LOC102115085 ^@ http://purl.uniprot.org/uniprot/A0A2K5UAP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:GABRA2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WF04|||http://purl.uniprot.org/uniprot/A0A2K5WF28|||http://purl.uniprot.org/uniprot/A0A7N9DDH1|||http://purl.uniprot.org/uniprot/G8F2J4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/9541:MOB3C ^@ http://purl.uniprot.org/uniprot/A0A2K5UZ90 ^@ Similarity ^@ Belongs to the MOB1/phocein family. http://togogenome.org/gene/9541:TMEM50A ^@ http://purl.uniprot.org/uniprot/A0A2K5TLA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9541:STIM2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X1T5|||http://purl.uniprot.org/uniprot/A0A2K5X1T8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:LOC102131808 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQ24|||http://purl.uniprot.org/uniprot/G7PP05 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/9541:ACSS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7L5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:ILDR1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1N8|||http://purl.uniprot.org/uniprot/G7NXR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/9541:CALHM1 ^@ http://purl.uniprot.org/uniprot/G7PDW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:PNPT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm http://togogenome.org/gene/9541:SLC8A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQV6|||http://purl.uniprot.org/uniprot/A0A2K5UQV7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/9541:LOC102115444 ^@ http://purl.uniprot.org/uniprot/A0A2K5WBL4 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/9541:REEP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5W174 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:MYO5C ^@ http://purl.uniprot.org/uniprot/A0A2K5U346 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/9541:LOC102136134 ^@ http://purl.uniprot.org/uniprot/A0A2K5U5A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:SVOPL ^@ http://purl.uniprot.org/uniprot/A0A2K5TNH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/9541:ELOF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/9541:EPHB3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W4J4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:DNMT3A ^@ http://purl.uniprot.org/uniprot/A0A2K5UUG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/9541:LIPI ^@ http://purl.uniprot.org/uniprot/A0A2K5TZA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/9541:AP5M1 ^@ http://purl.uniprot.org/uniprot/Q4R6Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.|||Belongs to the adaptor complexes medium subunit family.|||Late endosome membrane|||Lysosome membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.|||cytosol http://togogenome.org/gene/9541:EIF4E2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0X6|||http://purl.uniprot.org/uniprot/A0A2K5U110|||http://purl.uniprot.org/uniprot/G7PKB1 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/9541:SLC25A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3Q3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/9541:GTSF1 ^@ http://purl.uniprot.org/uniprot/Q4R8M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0224 (FAM112) family.|||Cytoplasm|||Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells. http://togogenome.org/gene/9541:CHCHD7 ^@ http://purl.uniprot.org/uniprot/Q8SPI2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CHCHD7 family.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9541:KIF3C ^@ http://purl.uniprot.org/uniprot/A0A8J8XNX6|||http://purl.uniprot.org/uniprot/G7PLS9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:CCNT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TJJ9|||http://purl.uniprot.org/uniprot/A0A8J8XC66|||http://purl.uniprot.org/uniprot/G7PN36 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:ALDH3B1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJD7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:FUT7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/9541:TEC ^@ http://purl.uniprot.org/uniprot/A0A2K5TW50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cytoplasm http://togogenome.org/gene/9541:CYFIP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYFIP family.|||synaptosome http://togogenome.org/gene/9541:SMC2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XL17|||http://purl.uniprot.org/uniprot/G7PRT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:MYOZ2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X6N6 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/9541:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A2K5UC83|||http://purl.uniprot.org/uniprot/A0A7N9D2N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102137006 ^@ http://purl.uniprot.org/uniprot/G8F3D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A2K5U1X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/9541:SLC46A3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:HS3ST5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VC73 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/9541:HNRNPA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWM9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PRPF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYM8 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/9541:ARL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5X4B6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:SLC39A6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:TMEM205 ^@ http://purl.uniprot.org/uniprot/A0A8J8XMN7|||http://purl.uniprot.org/uniprot/G7PZE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/9541:LOC102124928 ^@ http://purl.uniprot.org/uniprot/G7P1K8|||http://purl.uniprot.org/uniprot/Q4W7G9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/9541:LRRC8E ^@ http://purl.uniprot.org/uniprot/A0A2K5WKZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GNAT2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJM5|||http://purl.uniprot.org/uniprot/G7NW35 ^@ Similarity ^@ Belongs to the G-alpha family. G(i/o/t/z) subfamily. http://togogenome.org/gene/9541:TMEM87A ^@ http://purl.uniprot.org/uniprot/A0A2K5WC65|||http://purl.uniprot.org/uniprot/A0A8J8XB06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GPD1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YJY8|||http://purl.uniprot.org/uniprot/G7PIA0 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/9541:ATP5MK ^@ http://purl.uniprot.org/uniprot/A0A2K5WIY4 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion membrane http://togogenome.org/gene/9541:LHX5 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2A3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC102127506 ^@ http://purl.uniprot.org/uniprot/A0A8J8XD68|||http://purl.uniprot.org/uniprot/G7Q1V3 ^@ Similarity ^@ Belongs to the SPAN-X family. http://togogenome.org/gene/9541:TSPAN14 ^@ http://purl.uniprot.org/uniprot/A0A2K5X647 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:SEC13 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5M8|||http://purl.uniprot.org/uniprot/A0A8J8XDY5|||http://purl.uniprot.org/uniprot/G7NYT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane http://togogenome.org/gene/9541:CLDN7 ^@ http://purl.uniprot.org/uniprot/A0A2K5WU76 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:PRDM14 ^@ http://purl.uniprot.org/uniprot/A0A8J8YSJ2|||http://purl.uniprot.org/uniprot/G7PC03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CHD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW80|||http://purl.uniprot.org/uniprot/A0A8J8XLE1|||http://purl.uniprot.org/uniprot/G7P802 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:ZSCAN32 ^@ http://purl.uniprot.org/uniprot/A0A2K5TTN5 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:LOC102136612 ^@ http://purl.uniprot.org/uniprot/A0A2K5UE17 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/9541:CD3E ^@ http://purl.uniprot.org/uniprot/A0A2K5TR65|||http://purl.uniprot.org/uniprot/A0A2K5TR92|||http://purl.uniprot.org/uniprot/Q95LI5 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Membrane|||Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.|||Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.|||The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with CD6. Interacts with NCK1. Interacts with NUMB; this interaction is important for TCR-CD3 internalization and subsequent degradation. http://togogenome.org/gene/9541:EXTL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UWW7|||http://purl.uniprot.org/uniprot/A0A2K5UX31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:SLC45A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WDB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:METAP2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZJ5 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. http://togogenome.org/gene/9541:EMC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWC4|||http://purl.uniprot.org/uniprot/G8F3B3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/9541:AGAP3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WI02 ^@ Similarity ^@ Belongs to the centaurin gamma-like family. http://togogenome.org/gene/9541:CNOT9 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/9541:SPARC ^@ http://purl.uniprot.org/uniprot/A0A8J8XD95|||http://purl.uniprot.org/uniprot/G7P8R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/9541:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W5E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/9541:OGN ^@ http://purl.uniprot.org/uniprot/A0A8J8XM09|||http://purl.uniprot.org/uniprot/G7PSP7 ^@ Similarity ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. http://togogenome.org/gene/9541:CYP19A1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YF18|||http://purl.uniprot.org/uniprot/Q95LY0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/9541:SDHC ^@ http://purl.uniprot.org/uniprot/A0A2K5VYJ1|||http://purl.uniprot.org/uniprot/A0A2K5VYL2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/9541:TAFA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UW67 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/9541:CHMP5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNK1|||http://purl.uniprot.org/uniprot/G7PS50 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:TSPAN13 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:LIMS1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XB79|||http://purl.uniprot.org/uniprot/G7PMX1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/9541:GBA2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XAR2|||http://purl.uniprot.org/uniprot/G7PRZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the non-lysosomal glucosylceramidase family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. http://togogenome.org/gene/9541:RABAC1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y7H0|||http://purl.uniprot.org/uniprot/G7PXQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/9541:ASB14 ^@ http://purl.uniprot.org/uniprot/A0A2K5W3I0 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:CSTF3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UN07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CDH12 ^@ http://purl.uniprot.org/uniprot/A0A8J8YBU9|||http://purl.uniprot.org/uniprot/G7P7A5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:BBS5 ^@ http://purl.uniprot.org/uniprot/G7PKR7|||http://purl.uniprot.org/uniprot/Q4R649 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBS5 family.|||Cytoplasm|||Membrane|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10 (By similarity). Binds to phosphoinositides (By similarity). Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO (By similarity). Interacts with PKD1 (By similarity). Interacts with DLEC1 (By similarity).|||Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.|||centriolar satellite|||cilium basal body|||cilium membrane http://togogenome.org/gene/9541:POU2F2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UQU5|||http://purl.uniprot.org/uniprot/A0A7N9D5B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus http://togogenome.org/gene/9541:TBPL2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UUP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/9541:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/G7NWH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/9541:MC2R ^@ http://purl.uniprot.org/uniprot/G7PWB1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/9541:ALDH3A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZP3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:BVES ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1C4|||http://purl.uniprot.org/uniprot/G7P446 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9541:CTSH ^@ http://purl.uniprot.org/uniprot/A0A2K5TRN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/9541:SH3BGRL2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CI10 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/9541:ZDHHC17 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZT6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/9541:CD74 ^@ http://purl.uniprot.org/uniprot/A0A2K5U6J1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:DTYMK ^@ http://purl.uniprot.org/uniprot/A0A2K5TJ98 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/9541:LOC102121807 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:KIF16B ^@ http://purl.uniprot.org/uniprot/A0A2K5U453 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:IFT57 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/9541:MB21D2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V0U2 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/9541:FABP3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTZ6|||http://purl.uniprot.org/uniprot/G7NWW7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:ACLY ^@ http://purl.uniprot.org/uniprot/A0A2K5TWJ2 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/9541:SYS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/9541:SLC15A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7S5 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/9541:BET1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UYH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:NDUFS4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSU5|||http://purl.uniprot.org/uniprot/G7P7H7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:SS18L2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL77 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/9541:TSHZ2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XNW7|||http://purl.uniprot.org/uniprot/G7PFZ9 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/9541:GJA5 ^@ http://purl.uniprot.org/uniprot/A0A8J8YEV8|||http://purl.uniprot.org/uniprot/G7NTQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/9541:TDRD5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VUJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TDRD5 family.|||Cytoplasm|||Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. http://togogenome.org/gene/9541:LOC102133588 ^@ http://purl.uniprot.org/uniprot/A0A7N9D0H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GIMAP7 ^@ http://purl.uniprot.org/uniprot/G7P202 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/9541:GLS2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VU75 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/9541:CTNND1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZM3|||http://purl.uniprot.org/uniprot/A0A2K5UZP1|||http://purl.uniprot.org/uniprot/G7PQ26 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/9541:LMBR1L ^@ http://purl.uniprot.org/uniprot/G7PHS1|||http://purl.uniprot.org/uniprot/Q4R7X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LIMR family.|||Cell membrane|||Dimer (By similarity). Can also form higher oligomers (By similarity). Interacts with LCN1; this interaction mediates the endocytosis of LCN1 (By similarity). Interacts with UBAC2, FAF2, VCP, AMFR, ZNRF3, CTNNB1, LRP6, GSK3A, GSK3B, FZD6, DVL2 and RNF43 (By similarity). Interaction with LGB and SCGB1A1 is controversial (By similarity).|||Endoplasmic reticulum membrane|||Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (By similarity). http://togogenome.org/gene/9541:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y8T3|||http://purl.uniprot.org/uniprot/G7PMC6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/9541:SLC7A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5URE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ZNF687 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG95 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:EBF1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WH55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/9541:MIER3 ^@ http://purl.uniprot.org/uniprot/Q4R3R9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor. http://togogenome.org/gene/9541:DNAH6 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM92 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/9541:SLC30A8 ^@ http://purl.uniprot.org/uniprot/A0A2K5W7C8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/9541:ST3GAL2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZS4|||http://purl.uniprot.org/uniprot/G7Q1L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:GNA13 ^@ http://purl.uniprot.org/uniprot/A0A2K5TVH0|||http://purl.uniprot.org/uniprot/A0A7N9CMF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/9541:FXYD5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XKS7|||http://purl.uniprot.org/uniprot/G7PX84 ^@ Similarity ^@ Belongs to the FXYD family. http://togogenome.org/gene/9541:C20H16orf87 ^@ http://purl.uniprot.org/uniprot/A0A7N9CKG3 ^@ Similarity ^@ Belongs to the UPF0547 family. http://togogenome.org/gene/9541:DGAT2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VCG5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:PTTG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQ19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:BMP10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WNW7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/9541:EMC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7F9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:USB1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WCV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. http://togogenome.org/gene/9541:POLR3G ^@ http://purl.uniprot.org/uniprot/A0A7N9DIF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9541:PSMA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5W6A0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9541:LIPA ^@ http://purl.uniprot.org/uniprot/A0A2K5VBG9|||http://purl.uniprot.org/uniprot/Q4R4S5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol.|||Glycosylation is not essential for catalytic activity.|||Lysosome|||Monomer. http://togogenome.org/gene/9541:HOPX ^@ http://purl.uniprot.org/uniprot/I7GIM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A2K5VRJ2 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/9541:SFT2D1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XND2|||http://purl.uniprot.org/uniprot/G7P487 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/9541:CANX ^@ http://purl.uniprot.org/uniprot/A0A2K5UYZ9 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/9541:ZNF446 ^@ http://purl.uniprot.org/uniprot/A0A2K5UI12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:LOC107129555 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG77 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/9541:EPGN ^@ http://purl.uniprot.org/uniprot/A0A8J8YCK1|||http://purl.uniprot.org/uniprot/G7P5K4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:SH3GL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/9541:LOC102144964 ^@ http://purl.uniprot.org/uniprot/A0A8J8XVN4|||http://purl.uniprot.org/uniprot/G7NTR7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:KCNJ12 ^@ http://purl.uniprot.org/uniprot/A0A7N9D225|||http://purl.uniprot.org/uniprot/A0A8J8XCB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:VRK1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBQ9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/9541:INSL6 ^@ http://purl.uniprot.org/uniprot/A0A8J8YHS2|||http://purl.uniprot.org/uniprot/G7PSF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/9541:MRPL15 ^@ http://purl.uniprot.org/uniprot/A0A8J8XH12|||http://purl.uniprot.org/uniprot/G7PBU7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/9541:MMP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTD3|||http://purl.uniprot.org/uniprot/G7PNK5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M10A family.|||Binds 2 Zn(2+) ions per subunit.|||Can bind about 5 Ca(2+) ions per subunit. http://togogenome.org/gene/9541:GLRA2 ^@ http://purl.uniprot.org/uniprot/A0A7N9IDE3|||http://purl.uniprot.org/uniprot/A0A8J8YHI7|||http://purl.uniprot.org/uniprot/G7Q291 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/9541:EEF1G ^@ http://purl.uniprot.org/uniprot/Q4R7H5 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/9541:PALMD ^@ http://purl.uniprot.org/uniprot/A0A2K5U7C7 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/9541:RPN1 ^@ http://purl.uniprot.org/uniprot/Q4R4T0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with TMEM35A/NACHO (By similarity).|||Endoplasmic reticulum|||Endoplasmic reticulum membrane|||Melanosome|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.|||Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets. http://togogenome.org/gene/9541:NPTX1 ^@ http://purl.uniprot.org/uniprot/A0A7N9ICP5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LOC102131960 ^@ http://purl.uniprot.org/uniprot/A0A2K5V1Z8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:RPL31 ^@ http://purl.uniprot.org/uniprot/A0A8J8YQZ0|||http://purl.uniprot.org/uniprot/G7NZE1 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/9541:CAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W2A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:LOC102115611 ^@ http://purl.uniprot.org/uniprot/A0A2K5X5H2 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/9541:AAR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CY04 ^@ Function|||Similarity ^@ Belongs to the AAR2 family.|||Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. http://togogenome.org/gene/9541:BANF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U180 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:HVCN1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVC4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hydrogen channel family.|||Homodimer.|||Membrane http://togogenome.org/gene/9541:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A2K5URI7|||http://purl.uniprot.org/uniprot/A0A2K5URK1|||http://purl.uniprot.org/uniprot/A0A8J8XNJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Cell membrane|||Membrane|||Mitochondrion|||Nucleus|||Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.|||perinuclear region|||trans-Golgi network membrane http://togogenome.org/gene/9541:SLC35D1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SCAMP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WJX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/9541:PALS2 ^@ http://purl.uniprot.org/uniprot/Q4R814 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/9541:PSMG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UTC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PSMG1 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.|||Cytoplasm|||Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.|||Forms a heterodimer with psmg2. http://togogenome.org/gene/9541:LOC102124806 ^@ http://purl.uniprot.org/uniprot/A0A2K5V886 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.|||Secreted|||When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14. http://togogenome.org/gene/9541:BCLAF3 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDS4|||http://purl.uniprot.org/uniprot/G7Q2C2 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/9541:TNP1 ^@ http://purl.uniprot.org/uniprot/G7PLE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 1 family.|||Chromosome|||Nucleus http://togogenome.org/gene/9541:FLT1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VAF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:TBX22 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP92|||http://purl.uniprot.org/uniprot/G7Q341 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/9541:LOC102130791 ^@ http://purl.uniprot.org/uniprot/A0A2K5UP75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PADI6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XPE7|||http://purl.uniprot.org/uniprot/G7NUR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/9541:MICOS13 ^@ http://purl.uniprot.org/uniprot/G7PYT4|||http://purl.uniprot.org/uniprot/Q2ACH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic13 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:PNMA2 ^@ http://purl.uniprot.org/uniprot/Q9GMU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PNMA family.|||nucleolus http://togogenome.org/gene/9541:CHST10 ^@ http://purl.uniprot.org/uniprot/A0A8J8XHX9|||http://purl.uniprot.org/uniprot/G7PMT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/9541:TMEM178B ^@ http://purl.uniprot.org/uniprot/A0A2K5VJF5 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/9541:SLC2A11 ^@ http://purl.uniprot.org/uniprot/A0A2K5VQK6 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/9541:APEX1 ^@ http://purl.uniprot.org/uniprot/G8F5P8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/9541:VPS52 ^@ http://purl.uniprot.org/uniprot/A0A7N9D492 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/9541:FAM174B ^@ http://purl.uniprot.org/uniprot/A0A2K5U0X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/9541:TMEM33 ^@ http://purl.uniprot.org/uniprot/A0A8J8XUW8|||http://purl.uniprot.org/uniprot/G7P5H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/9541:LSM5 ^@ http://purl.uniprot.org/uniprot/A0A7N9D8I4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/9541:SLC17A5 ^@ http://purl.uniprot.org/uniprot/A0A2K5VPS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:SF3B5 ^@ http://purl.uniprot.org/uniprot/A0A2K5UMW7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/9541:HOXB1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/9541:UBA3 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLF3|||http://purl.uniprot.org/uniprot/A0A2K5WLL1 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/9541:PROK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WC32|||http://purl.uniprot.org/uniprot/A0A2K5WC77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/9541:EFNB1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CAH0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:EFNA5 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7N8|||http://purl.uniprot.org/uniprot/A0A8J8XVD8|||http://purl.uniprot.org/uniprot/G7P813 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:VPS53 ^@ http://purl.uniprot.org/uniprot/A0A2K5U0Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:PSMA5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XD69|||http://purl.uniprot.org/uniprot/G7NV55 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9541:TRIM9 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3V0|||http://purl.uniprot.org/uniprot/A0A7N9IEF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:FOXR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WV77 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FGR ^@ http://purl.uniprot.org/uniprot/A0A2K5WJL3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/9541:FAM13A ^@ http://purl.uniprot.org/uniprot/A0A2K5V740|||http://purl.uniprot.org/uniprot/A0A2K5V751|||http://purl.uniprot.org/uniprot/A0A2K5V776 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/9541:PELO ^@ http://purl.uniprot.org/uniprot/A0A2K5X8U8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.|||Cytoplasm http://togogenome.org/gene/9541:RETREG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:NREP ^@ http://purl.uniprot.org/uniprot/Q4R541 ^@ Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction. Interacts with FLNA.|||May have roles in neural function and cellular differentiation. Ectopic expression promotes axonal regeneration, induces differentiation of fibroblast into myofibroblast, induces myofibroblast ameboid migration, augments motility of gliomas, and increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.|||Phosphorylated on Ser-59. Phosphorylation decreases stability and activity. http://togogenome.org/gene/9541:PLPBP ^@ http://purl.uniprot.org/uniprot/G7PD65 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/9541:PPP2R5B ^@ http://purl.uniprot.org/uniprot/A0A2K5VWY4 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9541:DPP4 ^@ http://purl.uniprot.org/uniprot/A0A2K5VXJ1 ^@ Subcellular Location Annotation ^@ Cell membrane|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/9541:KBTBD8 ^@ http://purl.uniprot.org/uniprot/A0A2K5WA77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/9541:CDR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WHW2 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/9541:RPP14 ^@ http://purl.uniprot.org/uniprot/A0A2K5WD56 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/9541:HSD3B7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UGL1 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/9541:GADD45G ^@ http://purl.uniprot.org/uniprot/A0A2K5X2X3 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/9541:GOT1 ^@ http://purl.uniprot.org/uniprot/A0A805Q1X1 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/9541:GCG ^@ http://purl.uniprot.org/uniprot/A0A2K5WWG8 ^@ Similarity ^@ Belongs to the glucagon family. http://togogenome.org/gene/9541:CCDC65 ^@ http://purl.uniprot.org/uniprot/A0A2K5X8W7 ^@ Subcellular Location Annotation ^@ flagellum axoneme http://togogenome.org/gene/9541:SLC41A2 ^@ http://purl.uniprot.org/uniprot/A0A2K5TL38|||http://purl.uniprot.org/uniprot/Q4R335 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+).|||Belongs to the SLC41A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:GFRA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TWP5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.|||Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. http://togogenome.org/gene/9541:DDX49 ^@ http://purl.uniprot.org/uniprot/A0A2K5VP37 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/9541:INHA ^@ http://purl.uniprot.org/uniprot/A0A2K5U0P0|||http://purl.uniprot.org/uniprot/G7PK56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/9541:AGXT ^@ http://purl.uniprot.org/uniprot/A0A2K5VWZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Peroxisome http://togogenome.org/gene/9541:AZGP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TU41 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/9541:ARHGAP26 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJZ9|||http://purl.uniprot.org/uniprot/A0A7N9IDB1 ^@ Subcellular Location Annotation ^@ cytoskeleton|||focal adhesion http://togogenome.org/gene/9541:MID1 ^@ http://purl.uniprot.org/uniprot/A0A8J8YI77|||http://purl.uniprot.org/uniprot/G7Q274 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Nucleus|||cytoskeleton http://togogenome.org/gene/9541:OCIAD1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VJ58 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/9541:ARPC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5UPF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton|||synaptosome http://togogenome.org/gene/9541:BLOC1S6 ^@ http://purl.uniprot.org/uniprot/A0A2K5U4D3 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/9541:FUNDC1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VGS0|||http://purl.uniprot.org/uniprot/G8F3H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/9541:C18H18orf21 ^@ http://purl.uniprot.org/uniprot/A0A2K5WZR5|||http://purl.uniprot.org/uniprot/A0A2K5X0B3 ^@ Similarity ^@ Belongs to the UPF0711 family. http://togogenome.org/gene/9541:TMEM208 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/9541:ZNF75D ^@ http://purl.uniprot.org/uniprot/A0A2K5X9F7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:TAS2R4 ^@ http://purl.uniprot.org/uniprot/A0A7N9IHD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||cilium membrane http://togogenome.org/gene/9541:LOC102135548 ^@ http://purl.uniprot.org/uniprot/A0A7N9C9R4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:DDAH1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPG8 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/9541:XCL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/9541:ARL4D ^@ http://purl.uniprot.org/uniprot/A0A2K5UN88 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/9541:S100A16 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDV7|||http://purl.uniprot.org/uniprot/G7NUG9 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/9541:PGAP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UNM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/9541:C6H5orf22 ^@ http://purl.uniprot.org/uniprot/A0A2K5UT40 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/9541:CPNE9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBD9 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/9541:NPPA ^@ http://purl.uniprot.org/uniprot/A0A2K5VBM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the natriuretic peptide family.|||Cell projection|||Homodimer; disulfide-linked antiparallel dimer.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.|||May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.|||Secreted http://togogenome.org/gene/9541:CARTPT ^@ http://purl.uniprot.org/uniprot/A0A8J8YQB8|||http://purl.uniprot.org/uniprot/G7P7P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/9541:LYRM7 ^@ http://purl.uniprot.org/uniprot/A0A2K5V8X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/9541:SLC16A9 ^@ http://purl.uniprot.org/uniprot/A0A8J8YS42|||http://purl.uniprot.org/uniprot/G7PDF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:PKIG ^@ http://purl.uniprot.org/uniprot/A0A8J8XTY9|||http://purl.uniprot.org/uniprot/G7PGB4 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/9541:PTGS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTA5 ^@ Caution|||Similarity ^@ Belongs to the prostaglandin G/H synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ELSPBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UBA0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:AICDA ^@ http://purl.uniprot.org/uniprot/A0A2K5WJH5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:TSR2 ^@ http://purl.uniprot.org/uniprot/A0A7N9CWW3 ^@ Function|||Similarity ^@ Belongs to the TSR2 family.|||May be involved in 20S pre-rRNA processing. http://togogenome.org/gene/9541:SNX25 ^@ http://purl.uniprot.org/uniprot/A0A2K5WIU5 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/9541:GPR146 ^@ http://purl.uniprot.org/uniprot/Q8HXF4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/9541:IGF1R ^@ http://purl.uniprot.org/uniprot/A0A2K5W796 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/9541:SLC16A6 ^@ http://purl.uniprot.org/uniprot/A0A8J8XB19|||http://purl.uniprot.org/uniprot/G7PV86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:MBTPS2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D5H2|||http://purl.uniprot.org/uniprot/A0A8J8XRU4|||http://purl.uniprot.org/uniprot/G7Q2C9 ^@ Similarity ^@ Belongs to the peptidase M50A family. http://togogenome.org/gene/9541:EIF3E ^@ http://purl.uniprot.org/uniprot/Q4R6G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2 (By similarity). Interacts with IFIT1 and IFIT2 (By similarity). Interacts with BZW2/5MP1 (By similarity).|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.|||Cytoplasm|||PML body http://togogenome.org/gene/9541:EGFR ^@ http://purl.uniprot.org/uniprot/A0A2K5WK39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/9541:SLC16A4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WWK4|||http://purl.uniprot.org/uniprot/A0A2K5WWT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:GUCY1A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UZU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/9541:SIX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V3Q4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:GPER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WYF2|||http://purl.uniprot.org/uniprot/A0A8J8YA21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MDH1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VAL2|||http://purl.uniprot.org/uniprot/A0A7N9CNW0 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/9541:AK2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQR9|||http://purl.uniprot.org/uniprot/A0A7N9CVL8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/9541:LOC102121032 ^@ http://purl.uniprot.org/uniprot/G7PRS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:ACSF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VZB6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/9541:RNF152 ^@ http://purl.uniprot.org/uniprot/A0A8J8YFA8|||http://purl.uniprot.org/uniprot/G7PWW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/9541:MCHR2 ^@ http://purl.uniprot.org/uniprot/A0A2K5X035 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CCSER1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V547 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/9541:LDLRAD3 ^@ http://purl.uniprot.org/uniprot/A0A7N9C7V6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:EDC3 ^@ http://purl.uniprot.org/uniprot/A0A2K5VDI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/9541:SMIM22 ^@ http://purl.uniprot.org/uniprot/A0A8J8YC88|||http://purl.uniprot.org/uniprot/G7Q0F0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PBX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UKT8|||http://purl.uniprot.org/uniprot/A0A2K5UKW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/9541:WDR83OS ^@ http://purl.uniprot.org/uniprot/A0A2K5X8Q3 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/9541:RNF112 ^@ http://purl.uniprot.org/uniprot/A0A2K5U3J2 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/9541:KIF5B ^@ http://purl.uniprot.org/uniprot/A0A8J8XFK3|||http://purl.uniprot.org/uniprot/G7PEP7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/9541:CHMP4C ^@ http://purl.uniprot.org/uniprot/A0A2K5UK16 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/9541:LOC102138312 ^@ http://purl.uniprot.org/uniprot/A0A8J8XBQ0|||http://purl.uniprot.org/uniprot/G7PRZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/9541:DTX3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM11|||http://purl.uniprot.org/uniprot/A0A2K5TM17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/9541:CLPS ^@ http://purl.uniprot.org/uniprot/G7P3A9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/9541:MTOR ^@ http://purl.uniprot.org/uniprot/A0A2K5WYX7 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/9541:TMEM50B ^@ http://purl.uniprot.org/uniprot/G8F4V1|||http://purl.uniprot.org/uniprot/Q4R670 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/9541:CAMK2D ^@ http://purl.uniprot.org/uniprot/G7P650 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/9541:INTS9 ^@ http://purl.uniprot.org/uniprot/A0A2K5VH01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/9541:LOC102146578 ^@ http://purl.uniprot.org/uniprot/A0A2K5UX20 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/9541:TICAM1 ^@ http://purl.uniprot.org/uniprot/B3Y696 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.|||Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.|||Mitochondrion|||The N-terminal region is essential for activation of the IFNB promoter activity.|||autophagosome|||cytosol http://togogenome.org/gene/9541:CACNG2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WFY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/9541:HDAC11 ^@ http://purl.uniprot.org/uniprot/Q9GKU5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone deacetylase family.|||Interacts with HDAC6.|||Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). http://togogenome.org/gene/9541:ITGB8 ^@ http://purl.uniprot.org/uniprot/A0A8J8YB37|||http://purl.uniprot.org/uniprot/G7P0S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:MED23 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/9541:EIF2B4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CP23 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/9541:CRABP2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XJ89|||http://purl.uniprot.org/uniprot/G7NV96 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:CENPN ^@ http://purl.uniprot.org/uniprot/A0A8J8XL27|||http://purl.uniprot.org/uniprot/G7PZT4 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/9541:PPP2R5E ^@ http://purl.uniprot.org/uniprot/A0A2K5TKQ9 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/9541:DES ^@ http://purl.uniprot.org/uniprot/B3Y602 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/9541:SPCS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/9541:POPDC3 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y1R0|||http://purl.uniprot.org/uniprot/G7P447 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/9541:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VVF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WFIKKN family.|||Secreted http://togogenome.org/gene/9541:DDR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5V739 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:PPIC ^@ http://purl.uniprot.org/uniprot/A0A2K5V6K3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/9541:LOC102128376 ^@ http://purl.uniprot.org/uniprot/A0A2K5VWQ5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M2 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/9541:KNG1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WUB5 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/9541:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W1P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/9541:MDH1 ^@ http://purl.uniprot.org/uniprot/I7GHA1 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Homodimer. http://togogenome.org/gene/9541:FOLH1B ^@ http://purl.uniprot.org/uniprot/A0A2K5VNZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:RPGRIP1L ^@ http://purl.uniprot.org/uniprot/A0A2K5VF28 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/9541:ATP7A ^@ http://purl.uniprot.org/uniprot/A0A2K5X0T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/9541:LOC102137780 ^@ http://purl.uniprot.org/uniprot/A0A2K5VHL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:LOC102143686 ^@ http://purl.uniprot.org/uniprot/A0A7N9CJD3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/9541:STX17 ^@ http://purl.uniprot.org/uniprot/A0A8J8XDT2|||http://purl.uniprot.org/uniprot/I7GBM2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/9541:CHRM2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XET9|||http://purl.uniprot.org/uniprot/G7P0W8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/9541:CCL5 ^@ http://purl.uniprot.org/uniprot/G7PU47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/9541:LOC102118955 ^@ http://purl.uniprot.org/uniprot/A0A2K5WVY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/9541:RAP1B ^@ http://purl.uniprot.org/uniprot/Q4R9D4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner.|||Belongs to the small GTPase superfamily. Ras family.|||Cell junction|||Cell membrane|||GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).|||Heterodimer with RAP1GAP (By similarity). Interacts with EPAC2 (By similarity). Interacts with SGSM1 (By similarity). Interacts with SGSM2 (By similarity). Interacts with SGSM3 (By similarity). Interacts with KRIT1 (By similarity). Interacts with RAP1GDS1 (By similarity).|||cytosol http://togogenome.org/gene/9541:KEG98_p10 ^@ http://purl.uniprot.org/uniprot/C3W4Y8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:ZSCAN20 ^@ http://purl.uniprot.org/uniprot/A0A2K5TS95|||http://purl.uniprot.org/uniprot/A0A2K5TSB1 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/9541:SEPTIN4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WM76|||http://purl.uniprot.org/uniprot/A0A2K5WN04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/9541:NPY2R ^@ http://purl.uniprot.org/uniprot/A0A2K5UGU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CCNI ^@ http://purl.uniprot.org/uniprot/A0A7N9CZQ9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/9541:HYAL1 ^@ http://purl.uniprot.org/uniprot/A0A2K5W786|||http://purl.uniprot.org/uniprot/G7NXS8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/9541:BAAT ^@ http://purl.uniprot.org/uniprot/A0A2K5U9Z4 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/9541:BOLA1 ^@ http://purl.uniprot.org/uniprot/G7NTR8 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/9541:CPS1 ^@ http://purl.uniprot.org/uniprot/A0A2K5VK62 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:ANKS1B ^@ http://purl.uniprot.org/uniprot/I7G3R7|||http://purl.uniprot.org/uniprot/Q4R4X1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/9541:PSMD3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TLI1 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/9541:GNMT ^@ http://purl.uniprot.org/uniprot/A0A2K5VR98 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/9541:TNFRSF21 ^@ http://purl.uniprot.org/uniprot/A0A2K5VIJ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/9541:LYRM4 ^@ http://purl.uniprot.org/uniprot/A0A7N9CNF5 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/9541:S1PR1 ^@ http://purl.uniprot.org/uniprot/A0A7N9I9K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:CNOT10 ^@ http://purl.uniprot.org/uniprot/A0A2K5WX48|||http://purl.uniprot.org/uniprot/A0A8J8XNM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/9541:PCYOX1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WQJ3 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/9541:HSD17B3 ^@ http://purl.uniprot.org/uniprot/A0A2K5TM58 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/9541:LOC102123072 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/9541:SLC4A7 ^@ http://purl.uniprot.org/uniprot/A0A2K5UB14|||http://purl.uniprot.org/uniprot/A0A2K5UB60 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the anion exchanger (TC 2.A.31) family.|||Cell membrane|||Lateral cell membrane|||Membrane http://togogenome.org/gene/9541:TOMM40L ^@ http://purl.uniprot.org/uniprot/A0A8J8XG92|||http://purl.uniprot.org/uniprot/I7GJP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/9541:CBLIF ^@ http://purl.uniprot.org/uniprot/A0A2K5WX57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/9541:ASB15 ^@ http://purl.uniprot.org/uniprot/A0A2K5TQ56 ^@ Similarity ^@ Belongs to the ankyrin SOCS box (ASB) family. http://togogenome.org/gene/9541:CRABP1 ^@ http://purl.uniprot.org/uniprot/A0A7N9D888 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/9541:PRKACG ^@ http://purl.uniprot.org/uniprot/A0A2K5UPW7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/9541:CMKLR1 ^@ http://purl.uniprot.org/uniprot/A0A2K5UG47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/9541:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A2K5TPT0|||http://purl.uniprot.org/uniprot/A0A2K5TPT1|||http://purl.uniprot.org/uniprot/A0A2K5TPV0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/9541:SDHAF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5WLA7|||http://purl.uniprot.org/uniprot/Q9GMX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with SDHA within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. http://togogenome.org/gene/9541:NUBP1 ^@ http://purl.uniprot.org/uniprot/A0A2K5X7I4|||http://purl.uniprot.org/uniprot/A0A2K5X7Y1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/9541:PSMA7 ^@ http://purl.uniprot.org/uniprot/A0A2K5X9B7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/9541:TAS2R3 ^@ http://purl.uniprot.org/uniprot/A0A7N9DBR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/9541:PHYHIPL ^@ http://purl.uniprot.org/uniprot/A0A2K5WMU6 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/9541:TOB2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XZH4|||http://purl.uniprot.org/uniprot/G7PFN2 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/9541:LOC102130747 ^@ http://purl.uniprot.org/uniprot/A0A8J8XYD0|||http://purl.uniprot.org/uniprot/G7Q275 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/9541:NT5C3B ^@ http://purl.uniprot.org/uniprot/A0A2K5U762 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/9541:CD151 ^@ http://purl.uniprot.org/uniprot/A0A2K5WB08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:LDB2 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y9Y1|||http://purl.uniprot.org/uniprot/Q4R522 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/9541:NME5 ^@ http://purl.uniprot.org/uniprot/A0A2K5WL60 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/9541:MSX2 ^@ http://purl.uniprot.org/uniprot/A0A7N9D9E7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:FAM210A ^@ http://purl.uniprot.org/uniprot/A0A7N9CLE0 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/9541:EFNA1 ^@ http://purl.uniprot.org/uniprot/A0A2K5WTZ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:NRDC ^@ http://purl.uniprot.org/uniprot/A0A7N9DC69 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/9541:UROS ^@ http://purl.uniprot.org/uniprot/A0A2K5VG84|||http://purl.uniprot.org/uniprot/A0A7N9C9Y7|||http://purl.uniprot.org/uniprot/A0A7N9D060|||http://purl.uniprot.org/uniprot/A0A7N9D6H7 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/9541:AGBL3 ^@ http://purl.uniprot.org/uniprot/A0A2K5UME5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/9541:POLR3F ^@ http://purl.uniprot.org/uniprot/A0A2K5TYI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/9541:TSPAN18 ^@ http://purl.uniprot.org/uniprot/A0A7N9C837 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/9541:GLRB ^@ http://purl.uniprot.org/uniprot/A0A8J8XHE4|||http://purl.uniprot.org/uniprot/G7P6H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/9541:STEEP1 ^@ http://purl.uniprot.org/uniprot/A0A8J8XSK9|||http://purl.uniprot.org/uniprot/G7Q3K3 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/9541:CHAF1B ^@ http://purl.uniprot.org/uniprot/A0A2K5TRB7|||http://purl.uniprot.org/uniprot/A0A8J8Y6S7|||http://purl.uniprot.org/uniprot/G7P111 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CA5B ^@ http://purl.uniprot.org/uniprot/A0A2K5WNP4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/9541:GTF2E2 ^@ http://purl.uniprot.org/uniprot/A0A8J8XTQ5|||http://purl.uniprot.org/uniprot/G7PD55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/9541:DLX5 ^@ http://purl.uniprot.org/uniprot/A0A8J8XWF5|||http://purl.uniprot.org/uniprot/G7P1B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/9541:SELL ^@ http://purl.uniprot.org/uniprot/A0A7N9DE02 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selectin/LECAM family.|||Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.|||Cell membrane|||Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:MCCC2 ^@ http://purl.uniprot.org/uniprot/A0A2K5U7P9 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/9541:MMD ^@ http://purl.uniprot.org/uniprot/A0A8J8XAH4|||http://purl.uniprot.org/uniprot/G7PUD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/9541:TMOD4 ^@ http://purl.uniprot.org/uniprot/A0A2K5WG56 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/9541:LOC102118091 ^@ http://purl.uniprot.org/uniprot/A0A2K5UJK7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/9541:ZNF277 ^@ http://purl.uniprot.org/uniprot/A0A2K5U610 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/9541:CFL1 ^@ http://purl.uniprot.org/uniprot/Q4R5C0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin-binding proteins ADF family.|||Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity).|||Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (By similarity). It is a major component of intranuclear and cytoplasmic actin rods (By similarity). Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 and NLRP5 (By similarity). Interacts with C9orf72 (By similarity).|||Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2 (By similarity).|||Nucleus matrix|||axon|||cytoskeleton|||growth cone|||lamellipodium|||lamellipodium membrane|||ruffle membrane http://togogenome.org/gene/9541:TM7SF2 ^@ http://purl.uniprot.org/uniprot/I7GPM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/9541:MUSK ^@ http://purl.uniprot.org/uniprot/A0A2K5USF6|||http://purl.uniprot.org/uniprot/A0A2K5USG2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/9541:UCHL1 ^@ http://purl.uniprot.org/uniprot/I7GJN1 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/9541:CALHM6 ^@ http://purl.uniprot.org/uniprot/A0A8J8Y2T0|||http://purl.uniprot.org/uniprot/G7P3L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/9541:SLC16A13 ^@ http://purl.uniprot.org/uniprot/A0A2K5UEG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/9541:IL1R1 ^@ http://purl.uniprot.org/uniprot/A0A7N9CMI5 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/9541:SULF2 ^@ http://purl.uniprot.org/uniprot/A0A2K5VBR2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/9541:AVL9 ^@ http://purl.uniprot.org/uniprot/A0A2K5USR4 ^@ Subcellular Location Annotation ^@ Recycling endosome http://togogenome.org/gene/9541:TEAD2 ^@ http://purl.uniprot.org/uniprot/A0A2K5V9V8|||http://purl.uniprot.org/uniprot/A0A2K5V9X5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/9541:CLDN22 ^@ http://purl.uniprot.org/uniprot/A0A2K5UF63 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/9541:MMACHC ^@ http://purl.uniprot.org/uniprot/A0A2K5U3Q3 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/9541:EML6 ^@ http://purl.uniprot.org/uniprot/A0A2K5VMM7 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/9541:RPL38 ^@ http://purl.uniprot.org/uniprot/A0A8J8XP23|||http://purl.uniprot.org/uniprot/G7PVB2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/9541:ALPL ^@ http://purl.uniprot.org/uniprot/A0A2K5U1L9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alkaline phosphatase family.|||Binds 1 Mg(2+) ion.|||Binds 2 Zn(2+) ions.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/9541:PPOX ^@ http://purl.uniprot.org/uniprot/A0A8J8XJT1|||http://purl.uniprot.org/uniprot/G7NXA3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/9541:LBR ^@ http://purl.uniprot.org/uniprot/A0A2K5TKM6|||http://purl.uniprot.org/uniprot/A0A8J8XAI0|||http://purl.uniprot.org/uniprot/G7NTV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/9541:DCC ^@ http://purl.uniprot.org/uniprot/A0A2K5V8I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. DCC family.|||Membrane http://togogenome.org/gene/9541:DOK4 ^@ http://purl.uniprot.org/uniprot/A0A8J8XQP8|||http://purl.uniprot.org/uniprot/G7Q182 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/9541:PIWIL3 ^@ http://purl.uniprot.org/uniprot/G7PHF0 ^@ Similarity ^@ Belongs to the argonaute family.